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    <link:label id="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_2CB6FBE4D3A88071DD45715144EEC8D4_negatedTerseLabel_en-US" xlink:label="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_B88D2555D3235CBE8ADEE4FAE9009174" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Collateral Received</link:label>
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    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_937AFE979182594B3443715144EEA220_terseLabel_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_007E9DD446A7584FA0B90FB25B4CF956" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net Amount</link:label>
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_937AFE979182594B3443715144EEA220_label_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_007E9DD446A7584FA0B90FB25B4CF956" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Amount After Deducting Gross Amounts Not Offset on the Balance Sheet From Net Amount of Assets (Liabilities) Presented on the Balance Sheet</link:label>
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_937AFE979182594B3443715144EEA220_documentation_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_007E9DD446A7584FA0B90FB25B4CF956" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Net amount after deducting gross amounts not offset on the balance sheet from net amount of assets (liabilities) presented on the balance sheet.</link:label>
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    <link:label id="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_CB44F249542604A3F678D4EBDDBECE17_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_CB44F249542604A3F678D4EBDDBECE17" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net Unrealized Gain (Loss) on Swaps</link:label>
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    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_41EC9DE7CA17798729F4D4EBDDBE2518_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_41EC9DE7CA17798729F4D4EBDDBE2518" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Accumulated OCI Balance</link:label>
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    <link:label id="lab_us-gaap_ScheduleOfShortTermDebtTable_37939EEE26D6BF02F246E4F253115193_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShortTermDebtTable_37939EEE26D6BF02F246E4F253115193" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Short-term Debt [Table]</link:label>
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    <link:label id="lab_agnc_A37to48monthsMember_B37E92FD305D5C6E2781E4F253118140_terseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_B37E92FD305D5C6E2781E4F253118140" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_B37E92FD305D5C6E2781E4F253118140_label_en-US" xlink:label="lab_agnc_A37to48monthsMember_B37E92FD305D5C6E2781E4F253118140" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_B37E92FD305D5C6E2781E4F253118140_documentation_en-US" xlink:label="lab_agnc_A37to48monthsMember_B37E92FD305D5C6E2781E4F253118140" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_B37E92FD305D5C6E2781E4F253118140" xlink:type="locator" />
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    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_D423A06E8CD92D5F164FE4F25311FBDE_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_D423A06E8CD92D5F164FE4F25311FBDE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_D423A06E8CD92D5F164FE4F25311FBDE_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_D423A06E8CD92D5F164FE4F25311FBDE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_D423A06E8CD92D5F164FE4F25311FBDE" xlink:type="locator" />
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    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_121048445D35FA05C9A4E4F25311DCFB_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_121048445D35FA05C9A4E4F25311DCFB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Domain]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_121048445D35FA05C9A4E4F25311DCFB_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_121048445D35FA05C9A4E4F25311DCFB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_121048445D35FA05C9A4E4F25311DCFB" xlink:type="locator" />
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    <link:label id="lab_agnc_A49to60MonthsMember_9E54D2C6C3BAD974BC5EE4F25312D150_terseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_9E54D2C6C3BAD974BC5EE4F25312D150" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_9E54D2C6C3BAD974BC5EE4F25312D150_label_en-US" xlink:label="lab_agnc_A49to60MonthsMember_9E54D2C6C3BAD974BC5EE4F25312D150" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_9E54D2C6C3BAD974BC5EE4F25312D150_documentation_en-US" xlink:label="lab_agnc_A49to60MonthsMember_9E54D2C6C3BAD974BC5EE4F25312D150" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_9E54D2C6C3BAD974BC5EE4F25312D150" xlink:type="locator" />
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    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_28E6896ABF17C5916E31E4F253123C87_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_28E6896ABF17C5916E31E4F253123C87" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Less than 30 Days [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_28E6896ABF17C5916E31E4F253123C87_label_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_28E6896ABF17C5916E31E4F253123C87" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Less than 30 Days [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_28E6896ABF17C5916E31E4F253123C87" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_28E6896ABF17C5916E31E4F253123C87" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_28E6896ABF17C5916E31E4F253123C87" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C_terseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C_label_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C_documentation_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C" xlink:to="lab_agnc_ThirtyOneToNinetyMember_DFF0A41580188776A7CEE4F253125B8C" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A_verboseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A_label_en-US" xlink:label="lab_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A_documentation_en-US" xlink:label="lab_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A" xlink:to="lab_agnc_A4to6MonthsMember_F31F3625A8F6C1CA532BE4F25312BA7A" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_CB4953BD8A868CEB407FE4F25312D9C4_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis_CB4953BD8A868CEB407FE4F25312D9C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_CB4953BD8A868CEB407FE4F25312D9C4_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis_CB4953BD8A868CEB407FE4F25312D9C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_CB4953BD8A868CEB407FE4F25312D9C4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_CB4953BD8A868CEB407FE4F25312D9C4" xlink:to="lab_us-gaap_ShortTermDebtTypeAxis_CB4953BD8A868CEB407FE4F25312D9C4" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtTypeDomain_12FF9B3D70350AE25CA6E4F25312B83D_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeDomain_12FF9B3D70350AE25CA6E4F25312B83D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Domain]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtTypeDomain_12FF9B3D70350AE25CA6E4F25312B83D_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeDomain_12FF9B3D70350AE25CA6E4F25312B83D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_12FF9B3D70350AE25CA6E4F25312B83D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_12FF9B3D70350AE25CA6E4F25312B83D" xlink:to="lab_us-gaap_ShortTermDebtTypeDomain_12FF9B3D70350AE25CA6E4F25312B83D" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentAxis_E92CBF534D4C1032C5F1E4F25312BC77_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_E92CBF534D4C1032C5F1E4F25312BC77" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentAxis_E92CBF534D4C1032C5F1E4F25312BC77_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_E92CBF534D4C1032C5F1E4F25312BC77" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_E92CBF534D4C1032C5F1E4F25312BC77" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentAxis_E92CBF534D4C1032C5F1E4F25312BC77" xlink:to="lab_us-gaap_DebtInstrumentAxis_E92CBF534D4C1032C5F1E4F25312BC77" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_E2FCEFD5C94E39C93E0AE4F25312D1F0_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_E2FCEFD5C94E39C93E0AE4F25312D1F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_E2FCEFD5C94E39C93E0AE4F25312D1F0_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_E2FCEFD5C94E39C93E0AE4F25312D1F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_E2FCEFD5C94E39C93E0AE4F25312D1F0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_E2FCEFD5C94E39C93E0AE4F25312D1F0" xlink:to="lab_us-gaap_DebtInstrumentNameDomain_E2FCEFD5C94E39C93E0AE4F25312D1F0" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtLineItems_EE582E04B4C3F4EEEE4AE4F25312D66B_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems_EE582E04B4C3F4EEEE4AE4F25312D66B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtLineItems_EE582E04B4C3F4EEEE4AE4F25312D66B_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems_EE582E04B4C3F4EEEE4AE4F25312D66B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermDebtLineItems" xlink:label="loc_us-gaap_ShortTermDebtLineItems_EE582E04B4C3F4EEEE4AE4F25312D66B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtLineItems_EE582E04B4C3F4EEEE4AE4F25312D66B" xlink:to="lab_us-gaap_ShortTermDebtLineItems_EE582E04B4C3F4EEEE4AE4F25312D66B" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_0C231E12180F5EAA1A44E4F253123FAD_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_0C231E12180F5EAA1A44E4F253123FAD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Percentage Bearing Fixed Interest Rate</link:label>
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    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_E0BA90CA5239128679AE49A66FA2A042_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_6832CB829D48536BBABE9E7A9566671B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Weighted Average Life yield</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_E0BA90CA5239128679AE49A66FA2A042_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_6832CB829D48536BBABE9E7A9566671B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Weighted Average Life yield</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_6832CB829D48536BBABE9E7A9566671B" xlink:type="locator" />
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    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1A5237DA34369B8EA68449A66FD35B53_label_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_9E226F8CB4FA51E6ABA7CF937D10DBDD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1A5237DA34369B8EA68449A66FD35B53_documentation_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_9E226F8CB4FA51E6ABA7CF937D10DBDD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_9E226F8CB4FA51E6ABA7CF937D10DBDD" xlink:type="locator" />
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    <link:label id="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_72F950820C110FE290F549A66FD3B97B_terseLabel_en-US" xlink:label="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_21EC1FE90C6B54B2AAC41B31DB59FA7F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Federal Home Loan Bank Advances and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_72F950820C110FE290F549A66FD3B97B_label_en-US" xlink:label="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_21EC1FE90C6B54B2AAC41B31DB59FA7F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Federal Home Loan Bank Advances and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_72F950820C110FE290F549A66FD3B97B_documentation_en-US" xlink:label="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_21EC1FE90C6B54B2AAC41B31DB59FA7F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Federal Home Loan Bank Advances and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_21EC1FE90C6B54B2AAC41B31DB59FA7F" xlink:type="locator" />
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    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_95A9AFC2ABAC7633668E4E4F66622D2D_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock_85917149DB565613BDB89211A4248FAD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_95A9AFC2ABAC7633668E4E4F66622D2D_label_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock_85917149DB565613BDB89211A4248FAD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_85917149DB565613BDB89211A4248FAD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FederalHomeLoanBankStock_85917149DB565613BDB89211A4248FAD" xlink:to="lab_us-gaap_FederalHomeLoanBankStock_85917149DB565613BDB89211A4248FAD" xlink:type="arc" />
    <link:label id="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_C18D4409BB6CCE83C3214E4F6662D216_terseLabel_en-US" xlink:label="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_0B5CE854F5455A6E94F52543BEBA519B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Risk of interest swap and swaption agreements to stockholders' equity</link:label>
    <link:label id="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_C18D4409BB6CCE83C3214E4F6662D216_label_en-US" xlink:label="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_0B5CE854F5455A6E94F52543BEBA519B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit Derivative, Maximum Exposure, Undiscounted</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CreditDerivativeMaximumExposureUndiscounted" xlink:label="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_0B5CE854F5455A6E94F52543BEBA519B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_0B5CE854F5455A6E94F52543BEBA519B" xlink:to="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_0B5CE854F5455A6E94F52543BEBA519B" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_D436479025C439B4F7BCE4F25329E0E0_verboseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_D436479025C439B4F7BCE4F25329E0E0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">30 Days or Less [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_D436479025C439B4F7BCE4F25329E0E0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_D436479025C439B4F7BCE4F25329E0E0" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_D436479025C439B4F7BCE4F25329E0E0" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_0CF8ED49BB00D626BC08E4F25329363E_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_0CF8ED49BB00D626BC08E4F25329363E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">1 to 3 Months</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_0CF8ED49BB00D626BC08E4F25329363E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_0CF8ED49BB00D626BC08E4F25329363E" xlink:to="lab_agnc_ThirtyOneToNinetyMember_0CF8ED49BB00D626BC08E4F25329363E" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_BD233D66717CF5B3C629E4F2532977DC_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_BD233D66717CF5B3C629E4F2532977DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3 to 6 Months</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_BD233D66717CF5B3C629E4F2532977DC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_BD233D66717CF5B3C629E4F2532977DC" xlink:to="lab_agnc_A4to6MonthsMember_BD233D66717CF5B3C629E4F2532977DC" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0" xlink:to="lab_agnc_A7to9monthsMember_4D562C6C8133FA49646FE4F25329F0E0" xlink:type="arc" />
    <link:label id="lab_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43" xlink:to="lab_agnc_A10to12MonthsMember_1F9334108D48807E4CDDE4F25329CA43" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A" xlink:to="lab_agnc_A13to24MonthsMember_0626D0AE84D017737A45E4F253290D4A" xlink:type="arc" />
    <link:label id="lab_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25" xlink:to="lab_agnc_A25to36monthsMember_A463574F21CF188C404DE4F253299A25" xlink:type="arc" />
    <link:label id="lab_agnc_A37to48monthsMember_55BAA116BC4758EDD3DCE4F2532910FA_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_55BAA116BC4758EDD3DCE4F2532910FA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_55BAA116BC4758EDD3DCE4F2532910FA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A37to48monthsMember_55BAA116BC4758EDD3DCE4F2532910FA" xlink:to="lab_agnc_A37to48monthsMember_55BAA116BC4758EDD3DCE4F2532910FA" xlink:type="arc" />
    <link:label id="lab_agnc_A49to60MonthsMember_CDB05B953DC57BDB7CF3E4F25329993B_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_CDB05B953DC57BDB7CF3E4F25329993B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:loc xlink:href="agnc-20170331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_CDB05B953DC57BDB7CF3E4F25329993B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_CDB05B953DC57BDB7CF3E4F25329993B" xlink:to="lab_agnc_A49to60MonthsMember_CDB05B953DC57BDB7CF3E4F25329993B" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_303E20AB8E40F3D0A1EDE4F25329A3A1_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_303E20AB8E40F3D0A1EDE4F25329A3A1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_303E20AB8E40F3D0A1EDE4F25329A3A1_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_303E20AB8E40F3D0A1EDE4F25329A3A1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate</link:label>
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