<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
    <link:label id="lab_us-gaap_EquityAbstract_5B2905C5456AF1D11C96ADEB678C287E_label_en-US" xlink:label="lab_us-gaap_EquityAbstract_38B584EF71D45A89B2EB8D48474B5448" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_38B584EF71D45A89B2EB8D48474B5448" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityAbstract_38B584EF71D45A89B2EB8D48474B5448" xlink:to="lab_us-gaap_EquityAbstract_38B584EF71D45A89B2EB8D48474B5448" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_487B010E65C25F45CE93ADEB678C1FD6_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_F9D2F46AA54D5247B8917DAD9C07A2BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Accumulated Other Comprehensive Income (Loss)</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_487B010E65C25F45CE93ADEB678C1FD6_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_F9D2F46AA54D5247B8917DAD9C07A2BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_F9D2F46AA54D5247B8917DAD9C07A2BD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_F9D2F46AA54D5247B8917DAD9C07A2BD" xlink:to="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_F9D2F46AA54D5247B8917DAD9C07A2BD" xlink:type="arc" />
    <link:label id="lab_agnc_PledgedAssetsAbstract_5AFCF7FABA8CEC641FC3ADEB6827CDFF_label_en-US" xlink:label="lab_agnc_PledgedAssetsAbstract_A63498E892135D6E866742A3841E8299" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Pledged Assets [Abstract]</link:label>
    <link:label id="lab_agnc_PledgedAssetsAbstract_5AFCF7FABA8CEC641FC3ADEB6827CDFF_documentation_en-US" xlink:label="lab_agnc_PledgedAssetsAbstract_A63498E892135D6E866742A3841E8299" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Pledged Assets [Abstract]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_A63498E892135D6E866742A3841E8299" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PledgedAssetsAbstract_A63498E892135D6E866742A3841E8299" xlink:to="lab_agnc_PledgedAssetsAbstract_A63498E892135D6E866742A3841E8299" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_BA9F22E8A8C252BE9286ADEB6827DC84_terseLabel_en-US" xlink:label="lab_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_6080E587C81A528D8887E919C0995EB7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Securities and Cash Pledged as Collateral from Counterparties [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_BA9F22E8A8C252BE9286ADEB6827DC84_label_en-US" xlink:label="lab_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_6080E587C81A528D8887E919C0995EB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Securities and Cash Pledged as Collateral from Counterparties [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_BA9F22E8A8C252BE9286ADEB6827DC84_documentation_en-US" xlink:label="lab_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_6080E587C81A528D8887E919C0995EB7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Securities and Cash Pledged as Collateral from Counterparties [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock" xlink:label="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_6080E587C81A528D8887E919C0995EB7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_6080E587C81A528D8887E919C0995EB7" xlink:to="lab_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_6080E587C81A528D8887E919C0995EB7" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_2CACC57641C09F5C5827ADEB68273E56_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_06AF8D896C0F56389C1EF0E079F19AF4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Financial Instruments Owned and Pledged as Collateral</link:label>
    <link:label id="lab_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_2CACC57641C09F5C5827ADEB68273E56_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_06AF8D896C0F56389C1EF0E079F19AF4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Financial Instruments Owned and Pledged as Collateral [Table Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock" xlink:label="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_06AF8D896C0F56389C1EF0E079F19AF4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_06AF8D896C0F56389C1EF0E079F19AF4" xlink:to="lab_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_06AF8D896C0F56389C1EF0E079F19AF4" xlink:type="arc" />
    <link:label id="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_0F26FB428343809C4D6BADEB68276D40_terseLabel_en-US" xlink:label="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_26CC4A255C4A51558E3A802754F4264F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedules Of Securities Pledged As Collateral Under Repurchase Agreement</link:label>
    <link:label id="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_0F26FB428343809C4D6BADEB68276D40_label_en-US" xlink:label="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_26CC4A255C4A51558E3A802754F4264F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedules Of Securities Pledged As Collateral Under Repurchase Agreement [Text Block] [Table Text Block]</link:label>
    <link:label id="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_0F26FB428343809C4D6BADEB68276D40_documentation_en-US" xlink:label="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_26CC4A255C4A51558E3A802754F4264F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedules Of Securities Pledged As Collateral Under Repurchase Agreement [Text Block] [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:label="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_26CC4A255C4A51558E3A802754F4264F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_26CC4A255C4A51558E3A802754F4264F" xlink:to="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_26CC4A255C4A51558E3A802754F4264F" xlink:type="arc" />
    <link:label id="lab_us-gaap_OffsettingAssetsTableTextBlock_FDB1D62B7E4E285439DAADEB682739EA_terseLabel_en-US" xlink:label="lab_us-gaap_OffsettingAssetsTableTextBlock_D935F8886E355D6B863CF2B209FDC1FA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Offsetting Assets and Liabilities</link:label>
    <link:label id="lab_us-gaap_OffsettingAssetsTableTextBlock_FDB1D62B7E4E285439DAADEB682739EA_label_en-US" xlink:label="lab_us-gaap_OffsettingAssetsTableTextBlock_D935F8886E355D6B863CF2B209FDC1FA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Offsetting Assets [Table Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OffsettingAssetsTableTextBlock" xlink:label="loc_us-gaap_OffsettingAssetsTableTextBlock_D935F8886E355D6B863CF2B209FDC1FA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OffsettingAssetsTableTextBlock_D935F8886E355D6B863CF2B209FDC1FA" xlink:to="lab_us-gaap_OffsettingAssetsTableTextBlock_D935F8886E355D6B863CF2B209FDC1FA" xlink:type="arc" />
    <link:label id="lab_us-gaap_OffsettingLiabilitiesTableTextBlock_3325D1F465D774FD6F0BADEB68276396_terseLabel_en-US" xlink:label="lab_us-gaap_OffsettingLiabilitiesTableTextBlock_27D1CD630F3A5358BAED3338DEE7D25B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Offsetting Liabilities</link:label>
    <link:label id="lab_us-gaap_OffsettingLiabilitiesTableTextBlock_3325D1F465D774FD6F0BADEB68276396_label_en-US" xlink:label="lab_us-gaap_OffsettingLiabilitiesTableTextBlock_27D1CD630F3A5358BAED3338DEE7D25B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Offsetting Liabilities [Table Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_27D1CD630F3A5358BAED3338DEE7D25B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_27D1CD630F3A5358BAED3338DEE7D25B" xlink:to="lab_us-gaap_OffsettingLiabilitiesTableTextBlock_27D1CD630F3A5358BAED3338DEE7D25B" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccountingPoliciesAbstract_9D0297E8BDB3A1350777ADEB676FB3BF_label_en-US" xlink:label="lab_us-gaap_AccountingPoliciesAbstract_2AD4741E997B5AC7A265C1E0B22FD81B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounting Policies [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_2AD4741E997B5AC7A265C1E0B22FD81B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_2AD4741E997B5AC7A265C1E0B22FD81B" xlink:to="lab_us-gaap_AccountingPoliciesAbstract_2AD4741E997B5AC7A265C1E0B22FD81B" xlink:type="arc" />
    <link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_1BED4B6E27CAFC19EA4DADEB676FAA4D_verboseLabel_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_48FC8D449CE35FAD9082A5E996623CBC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Summary of Significant Accounting Policies</link:label>
    <link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_1BED4B6E27CAFC19EA4DADEB676FAA4D_label_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_48FC8D449CE35FAD9082A5E996623CBC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Significant Accounting Policies [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_48FC8D449CE35FAD9082A5E996623CBC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SignificantAccountingPoliciesTextBlock_48FC8D449CE35FAD9082A5E996623CBC" xlink:to="lab_us-gaap_SignificantAccountingPoliciesTextBlock_48FC8D449CE35FAD9082A5E996623CBC" xlink:type="arc" />
    <link:label id="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_26BA86E95C0DFFE15614105756E1D599_label_en-US" xlink:label="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_26BA86E95C0DFFE15614105756E1D599" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Disclosure of Repurchase Agreements [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_26BA86E95C0DFFE15614105756E1D599" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_26BA86E95C0DFFE15614105756E1D599" xlink:to="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_26BA86E95C0DFFE15614105756E1D599" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A22C633E61A43B6A0851105756E16E20_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A22C633E61A43B6A0851105756E16E20" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Assets Sold under Agreements to Repurchase [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A22C633E61A43B6A0851105756E16E20_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A22C633E61A43B6A0851105756E16E20" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Assets Sold under Agreements to Repurchase [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A22C633E61A43B6A0851105756E16E20" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A22C633E61A43B6A0851105756E16E20" xlink:to="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A22C633E61A43B6A0851105756E16E20" xlink:type="arc" />
    <link:label id="lab_us-gaap_CounterpartyNameAxis_ED3F3112E7A3859ADB79105756E29656_terseLabel_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_ED3F3112E7A3859ADB79105756E29656" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Counterparty Name [Axis]</link:label>
    <link:label id="lab_us-gaap_CounterpartyNameAxis_ED3F3112E7A3859ADB79105756E29656_label_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_ED3F3112E7A3859ADB79105756E29656" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Counterparty Name [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_ED3F3112E7A3859ADB79105756E29656" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CounterpartyNameAxis_ED3F3112E7A3859ADB79105756E29656" xlink:to="lab_us-gaap_CounterpartyNameAxis_ED3F3112E7A3859ADB79105756E29656" xlink:type="arc" />
    <link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_D70B1913C175AC3531C4105756E2B438_terseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_D70B1913C175AC3531C4105756E2B438" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Counterparty Name [Domain]</link:label>
    <link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_D70B1913C175AC3531C4105756E2B438_label_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_D70B1913C175AC3531C4105756E2B438" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Counterparty Name [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_D70B1913C175AC3531C4105756E2B438" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_D70B1913C175AC3531C4105756E2B438" xlink:to="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_D70B1913C175AC3531C4105756E2B438" xlink:type="arc" />
    <link:label id="lab_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5_terseLabel_en-US" xlink:label="lab_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Bethesda Securities [Member]</link:label>
    <link:label id="lab_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5_label_en-US" xlink:label="lab_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Bethesda Securities [Member]</link:label>
    <link:label id="lab_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5_documentation_en-US" xlink:label="lab_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Bethesda Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_BethesdaSecuritiesMember" xlink:label="loc_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5" xlink:to="lab_agnc_BethesdaSecuritiesMember_22756D62457163EB6DC7105756E2B6B5" xlink:type="arc" />
    <link:label id="lab_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D_terseLabel_en-US" xlink:label="lab_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">FICC [Member]</link:label>
    <link:label id="lab_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D_label_en-US" xlink:label="lab_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">FICC [Member]</link:label>
    <link:label id="lab_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D_documentation_en-US" xlink:label="lab_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">FICC [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_FICCMember" xlink:label="loc_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D" xlink:to="lab_agnc_FICCMember_2BD3C5937C359542C368105756E20D9D" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentAxis_9DE8A6E99CA4A091CE7C105756E39012_terseLabel_en-US" xlink:label="lab_invest_InvestmentAxis_9DE8A6E99CA4A091CE7C105756E39012" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment [Axis]</link:label>
    <link:label id="lab_invest_InvestmentAxis_9DE8A6E99CA4A091CE7C105756E39012_label_en-US" xlink:label="lab_invest_InvestmentAxis_9DE8A6E99CA4A091CE7C105756E39012" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_9DE8A6E99CA4A091CE7C105756E39012" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentAxis_9DE8A6E99CA4A091CE7C105756E39012" xlink:to="lab_invest_InvestmentAxis_9DE8A6E99CA4A091CE7C105756E39012" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentDomain_0DE069B6C1AFC136EFD6105756E32CFC_terseLabel_en-US" xlink:label="lab_invest_InvestmentDomain_0DE069B6C1AFC136EFD6105756E32CFC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:label id="lab_invest_InvestmentDomain_0DE069B6C1AFC136EFD6105756E32CFC_label_en-US" xlink:label="lab_invest_InvestmentDomain_0DE069B6C1AFC136EFD6105756E32CFC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_0DE069B6C1AFC136EFD6105756E32CFC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentDomain_0DE069B6C1AFC136EFD6105756E32CFC" xlink:to="lab_invest_InvestmentDomain_0DE069B6C1AFC136EFD6105756E32CFC" xlink:type="arc" />
    <link:label id="lab_us-gaap_AgencySecuritiesMember_88167B2CD0FBE84D1596105756E3DC44_terseLabel_en-US" xlink:label="lab_us-gaap_AgencySecuritiesMember_88167B2CD0FBE84D1596105756E3DC44" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Agency Securities [Member]</link:label>
    <link:label id="lab_us-gaap_AgencySecuritiesMember_88167B2CD0FBE84D1596105756E3DC44_label_en-US" xlink:label="lab_us-gaap_AgencySecuritiesMember_88167B2CD0FBE84D1596105756E3DC44" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Agency Securities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_88167B2CD0FBE84D1596105756E3DC44" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AgencySecuritiesMember_88167B2CD0FBE84D1596105756E3DC44" xlink:to="lab_us-gaap_AgencySecuritiesMember_88167B2CD0FBE84D1596105756E3DC44" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtSecurityAxis_F600F5A8C9C09ACFF346105756E3FEF2_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecurityAxis_F600F5A8C9C09ACFF346105756E3FEF2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Security [Axis]</link:label>
    <link:label id="lab_us-gaap_DebtSecurityAxis_F600F5A8C9C09ACFF346105756E3FEF2_label_en-US" xlink:label="lab_us-gaap_DebtSecurityAxis_F600F5A8C9C09ACFF346105756E3FEF2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Security [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtSecurityAxis" xlink:label="loc_us-gaap_DebtSecurityAxis_F600F5A8C9C09ACFF346105756E3FEF2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecurityAxis_F600F5A8C9C09ACFF346105756E3FEF2" xlink:to="lab_us-gaap_DebtSecurityAxis_F600F5A8C9C09ACFF346105756E3FEF2" xlink:type="arc" />
    <link:label id="lab_us-gaap_MajorTypesOfDebtSecuritiesDomain_36D14E9B17085F143E39105756E4A1DC_terseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtSecuritiesDomain_36D14E9B17085F143E39105756E4A1DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Major Types of Debt Securities [Domain]</link:label>
    <link:label id="lab_us-gaap_MajorTypesOfDebtSecuritiesDomain_36D14E9B17085F143E39105756E4A1DC_label_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtSecuritiesDomain_36D14E9B17085F143E39105756E4A1DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Types of Debt Securities [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MajorTypesOfDebtSecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtSecuritiesDomain_36D14E9B17085F143E39105756E4A1DC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtSecuritiesDomain_36D14E9B17085F143E39105756E4A1DC" xlink:to="lab_us-gaap_MajorTypesOfDebtSecuritiesDomain_36D14E9B17085F143E39105756E4A1DC" xlink:type="arc" />
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_0C47D4F14404049912B6105756E47774_terseLabel_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember_0C47D4F14404049912B6105756E47774" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">US Treasury Securities [Member]</link:label>
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_0C47D4F14404049912B6105756E47774_label_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember_0C47D4F14404049912B6105756E47774" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">US Treasury Securities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_0C47D4F14404049912B6105756E47774" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_USTreasurySecuritiesMember_0C47D4F14404049912B6105756E47774" xlink:to="lab_us-gaap_USTreasurySecuritiesMember_0C47D4F14404049912B6105756E47774" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5675DC4883B73FE0EEF3105756E53ACE_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5675DC4883B73FE0EEF3105756E53ACE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]</link:label>
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5675DC4883B73FE0EEF3105756E53ACE_label_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5675DC4883B73FE0EEF3105756E53ACE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5675DC4883B73FE0EEF3105756E53ACE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5675DC4883B73FE0EEF3105756E53ACE" xlink:to="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5675DC4883B73FE0EEF3105756E53ACE" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_50EA38D0E84FB59A4D71105756E5472D_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_50EA38D0E84FB59A4D71105756E5472D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Domain]</link:label>
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_50EA38D0E84FB59A4D71105756E5472D_label_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_50EA38D0E84FB59A4D71105756E5472D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_50EA38D0E84FB59A4D71105756E5472D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_50EA38D0E84FB59A4D71105756E5472D" xlink:to="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_50EA38D0E84FB59A4D71105756E5472D" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_2C7BCFD0ED6EB45AB169105756E5E85C_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_2C7BCFD0ED6EB45AB169105756E5E85C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_2C7BCFD0ED6EB45AB169105756E5E85C_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_2C7BCFD0ED6EB45AB169105756E5E85C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_2C7BCFD0ED6EB45AB169105756E5E85C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_2C7BCFD0ED6EB45AB169105756E5E85C" xlink:to="lab_us-gaap_DerivativeInstrumentRiskAxis_2C7BCFD0ED6EB45AB169105756E5E85C" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeContractTypeDomain_AFCAA8B008CDD7B4FCA4105756E5C79D_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_AFCAA8B008CDD7B4FCA4105756E5C79D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Contract [Domain]</link:label>
    <link:label id="lab_us-gaap_DerivativeContractTypeDomain_AFCAA8B008CDD7B4FCA4105756E5C79D_label_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_AFCAA8B008CDD7B4FCA4105756E5C79D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Contract [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_AFCAA8B008CDD7B4FCA4105756E5C79D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_AFCAA8B008CDD7B4FCA4105756E5C79D" xlink:to="lab_us-gaap_DerivativeContractTypeDomain_AFCAA8B008CDD7B4FCA4105756E5C79D" xlink:type="arc" />
    <link:label id="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A_terseLabel_en-US" xlink:label="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">TBA securities Fifteen Year and Thirty Year Securities [Member]</link:label>
    <link:label id="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A_label_en-US" xlink:label="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">TBA securities Fifteen Year and Thirty Year Securities [Member]</link:label>
    <link:label id="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A_documentation_en-US" xlink:label="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">TBA securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:label="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A" xlink:to="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_63D4B4EB67640479261E105756E66D6A" xlink:type="arc" />
    <link:label id="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B_terseLabel_en-US" xlink:label="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">TBA and Forward Settling Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B_label_en-US" xlink:label="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">TBA and Forward Settling Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B_documentation_en-US" xlink:label="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">TBA and Forward Settling Agency Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B" xlink:to="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_CCF2250FEC24AD6AEB1E105756E61A0B" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_95956CD8768F78C55782105756E6F94C_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_95956CD8768F78C55782105756E6F94C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets Sold under Agreements to Repurchase [Line Items]</link:label>
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_95956CD8768F78C55782105756E6F94C_label_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_95956CD8768F78C55782105756E6F94C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets Sold under Agreements to Repurchase [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_95956CD8768F78C55782105756E6F94C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_95956CD8768F78C55782105756E6F94C" xlink:to="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_95956CD8768F78C55782105756E6F94C" xlink:type="arc" />
    <link:label id="lab_dei_DocumentPeriodEndDate_5E2FA73287DA3C41A809105756E6F78F_terseLabel_en-US" xlink:label="lab_dei_DocumentPeriodEndDate_5E2FA73287DA3C41A809105756E6F78F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Document Period End Date</link:label>
    <link:label id="lab_dei_DocumentPeriodEndDate_5E2FA73287DA3C41A809105756E6F78F_label_en-US" xlink:label="lab_dei_DocumentPeriodEndDate_5E2FA73287DA3C41A809105756E6F78F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Period End Date</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_5E2FA73287DA3C41A809105756E6F78F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentPeriodEndDate_5E2FA73287DA3C41A809105756E6F78F" xlink:to="lab_dei_DocumentPeriodEndDate_5E2FA73287DA3C41A809105756E6F78F" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_88650DB0C21D67531965105756E7B419_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_88650DB0C21D67531965105756E7B419" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities Sold under Agreements to Repurchase</link:label>
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_88650DB0C21D67531965105756E7B419_label_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_88650DB0C21D67531965105756E7B419" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Sold under Agreements to Repurchase</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_88650DB0C21D67531965105756E7B419" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_88650DB0C21D67531965105756E7B419" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_88650DB0C21D67531965105756E7B419" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A_terseLabel_en-US" xlink:label="lab_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Forward Settlement Value</link:label>
    <link:label id="lab_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A_label_en-US" xlink:label="lab_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative, Forward Settlement Value</link:label>
    <link:label id="lab_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A_documentation_en-US" xlink:label="lab_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative, Forward Settlement Value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A" xlink:to="lab_agnc_DerivativeForwardSettlementValue_4BEE794B35A3396F960E105756E7926A" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeNet_CA8FFA09E01AB699DBD0105756E776D1_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeNet_CA8FFA09E01AB699DBD0105756E776D1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Fair Value, Net</link:label>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeNet_CA8FFA09E01AB699DBD0105756E776D1_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeNet_CA8FFA09E01AB699DBD0105756E776D1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative, Fair Value, Net</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_CA8FFA09E01AB699DBD0105756E776D1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeNet_CA8FFA09E01AB699DBD0105756E776D1" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeNet_CA8FFA09E01AB699DBD0105756E776D1" xlink:type="arc" />
    <link:label id="lab_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333_terseLabel_en-US" xlink:label="lab_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Percentage of Repurchase Agreement Funding</link:label>
    <link:label id="lab_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333_label_en-US" xlink:label="lab_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Percentage of Repurchase Agreement Funding</link:label>
    <link:label id="lab_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333_documentation_en-US" xlink:label="lab_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Percentage of Repurchase Agreement Funding</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PercentageofRepurchaseAgreementFunding" xlink:label="loc_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333" xlink:to="lab_agnc_PercentageofRepurchaseAgreementFunding_DD8C1DE106A75702878E105756E73333" xlink:type="arc" />
    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D_terseLabel_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Obligation to Return Securities Borrowed Under Reverse Repurchase Agreements at Fair Value</link:label>
    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D_label_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Obligation to Return Securities Borrowed Under Reverse Repurchase Agreements at Fair Value</link:label>
    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D_documentation_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Obligation to Return Securities Borrowed Under Reverse Repurchase Agreements at Fair Value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D" xlink:to="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A706A8917E988520D29510593A899E5D" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherLongTermDebt_EBFD75BBC779D9DB0E7F105756E7C32B_negatedLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt_EBFD75BBC779D9DB0E7F105756E7C32B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Debt of consolidated variable interest entities, at fair value</link:label>
    <link:label id="lab_us-gaap_OtherLongTermDebt_EBFD75BBC779D9DB0E7F105756E7C32B_label_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt_EBFD75BBC779D9DB0E7F105756E7C32B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Long-term Debt</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_EBFD75BBC779D9DB0E7F105756E7C32B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLongTermDebt_EBFD75BBC779D9DB0E7F105756E7C32B" xlink:to="lab_us-gaap_OtherLongTermDebt_EBFD75BBC779D9DB0E7F105756E7C32B" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_275D8868A2B8AFD1DBED105756E7C85E_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_275D8868A2B8AFD1DBED105756E7C85E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Description of variable rate basis</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_275D8868A2B8AFD1DBED105756E7C85E_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_275D8868A2B8AFD1DBED105756E7C85E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Description of Variable Rate Basis</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_275D8868A2B8AFD1DBED105756E7C85E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_275D8868A2B8AFD1DBED105756E7C85E" xlink:to="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_275D8868A2B8AFD1DBED105756E7C85E" xlink:type="arc" />
    <link:label id="lab_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6_terseLabel_en-US" xlink:label="lab_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Basis spread over LIBOR</link:label>
    <link:label id="lab_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6_label_en-US" xlink:label="lab_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Spread Over LIBOR</link:label>
    <link:label id="lab_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6_documentation_en-US" xlink:label="lab_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Spread Over LIBOR</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SpreadOverLibor" xlink:label="loc_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6" xlink:to="lab_agnc_SpreadOverLibor_2EC766BC11A2F3E0CDD7105756E8A8B6" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentFaceAmount_8D6AFCF513F30CF38EE0105756E8BBEC_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_8D6AFCF513F30CF38EE0105756E8BBEC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Principal amount</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentFaceAmount_8D6AFCF513F30CF38EE0105756E8BBEC_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_8D6AFCF513F30CF38EE0105756E8BBEC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Face Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_8D6AFCF513F30CF38EE0105756E8BBEC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentFaceAmount_8D6AFCF513F30CF38EE0105756E8BBEC" xlink:to="lab_us-gaap_DebtInstrumentFaceAmount_8D6AFCF513F30CF38EE0105756E8BBEC" xlink:type="arc" />
    <link:label id="lab_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted average life of other debt</link:label>
    <link:label id="lab_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3_label_en-US" xlink:label="lab_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted Average Life Other Debt</link:label>
    <link:label id="lab_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3_documentation_en-US" xlink:label="lab_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Weighted Average Life Other Debt</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_WeightedAverageLifeOtherDebt" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3" xlink:to="lab_agnc_WeightedAverageLifeOtherDebt_0B16F873D513DC3896E7105756E8C4C3" xlink:type="arc" />
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59_terseLabel_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Offsetting Assets and Liabilities [Table]</link:label>
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59_label_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Offsetting Assets and Liabilities [Table]</link:label>
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59_documentation_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Offsetting Assets and Liabilities [Table]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59" xlink:to="lab_agnc_OffsettingAssetsAndLiabilitiesTable_D29B4657175CF719AA0F00ACB43C4E59" xlink:type="arc" />
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_B1D13A30A77BED47874600ACB43DC95E_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_B1D13A30A77BED47874600ACB43DC95E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Restricted Cash and Cash Equivalents [Axis]</link:label>
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_B1D13A30A77BED47874600ACB43DC95E_label_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_B1D13A30A77BED47874600ACB43DC95E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Restricted Cash and Cash Equivalents [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_B1D13A30A77BED47874600ACB43DC95E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_B1D13A30A77BED47874600ACB43DC95E" xlink:to="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_B1D13A30A77BED47874600ACB43DC95E" xlink:type="arc" />
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11FE202EA856AEFA9F0800ACB43DECB9_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11FE202EA856AEFA9F0800ACB43DECB9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents [Domain]</link:label>
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11FE202EA856AEFA9F0800ACB43DECB9_label_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11FE202EA856AEFA9F0800ACB43DECB9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11FE202EA856AEFA9F0800ACB43DECB9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11FE202EA856AEFA9F0800ACB43DECB9" xlink:to="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11FE202EA856AEFA9F0800ACB43DECB9" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeMember_EE587B8BD70EA5471F8D00ACB43E9C52_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeMember_EE587B8BD70EA5471F8D00ACB43E9C52" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative [Member]</link:label>
    <link:label id="lab_us-gaap_DerivativeMember_EE587B8BD70EA5471F8D00ACB43E9C52_label_en-US" xlink:label="lab_us-gaap_DerivativeMember_EE587B8BD70EA5471F8D00ACB43E9C52" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeMember" xlink:label="loc_us-gaap_DerivativeMember_EE587B8BD70EA5471F8D00ACB43E9C52" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeMember_EE587B8BD70EA5471F8D00ACB43E9C52" xlink:to="lab_us-gaap_DerivativeMember_EE587B8BD70EA5471F8D00ACB43E9C52" xlink:type="arc" />
    <link:label id="lab_us-gaap_InvestmentTypeAxis_604509E26E53D0ACF1D200ACB43ECAB9_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis_604509E26E53D0ACF1D200ACB43ECAB9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Type [Axis]</link:label>
    <link:label id="lab_us-gaap_InvestmentTypeAxis_604509E26E53D0ACF1D200ACB43ECAB9_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis_604509E26E53D0ACF1D200ACB43ECAB9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment Type [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_604509E26E53D0ACF1D200ACB43ECAB9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentTypeAxis_604509E26E53D0ACF1D200ACB43ECAB9" xlink:to="lab_us-gaap_InvestmentTypeAxis_604509E26E53D0ACF1D200ACB43ECAB9" xlink:type="arc" />
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_A9D6574FF63FA46D7D3E00ACB43F2D5B_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember_A9D6574FF63FA46D7D3E00ACB43F2D5B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investments [Domain]</link:label>
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_A9D6574FF63FA46D7D3E00ACB43F2D5B_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember_A9D6574FF63FA46D7D3E00ACB43F2D5B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investments [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_A9D6574FF63FA46D7D3E00ACB43F2D5B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_A9D6574FF63FA46D7D3E00ACB43F2D5B" xlink:to="lab_us-gaap_InvestmentTypeCategorizationMember_A9D6574FF63FA46D7D3E00ACB43F2D5B" xlink:type="arc" />
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68_terseLabel_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Reverse Repurchase Agreements [Member]</link:label>
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68_label_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reverse Repurchase Agreements [Member]</link:label>
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68_documentation_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Reverse Repurchase Agreements [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ReverseRepurchaseAgreementsMember" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68" xlink:to="lab_agnc_ReverseRepurchaseAgreementsMember_42A68B2BA7EC805BA2A500ACB43FFB68" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentSecuritiesClassAxis_6D34DE246487280A78EF00ACB43FFE6D_terseLabel_en-US" xlink:label="lab_invest_InvestmentSecuritiesClassAxis_6D34DE246487280A78EF00ACB43FFE6D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Securities Class [Axis]</link:label>
    <link:label id="lab_invest_InvestmentSecuritiesClassAxis_6D34DE246487280A78EF00ACB43FFE6D_label_en-US" xlink:label="lab_invest_InvestmentSecuritiesClassAxis_6D34DE246487280A78EF00ACB43FFE6D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment Securities Class [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassAxis" xlink:label="loc_invest_InvestmentSecuritiesClassAxis_6D34DE246487280A78EF00ACB43FFE6D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentSecuritiesClassAxis_6D34DE246487280A78EF00ACB43FFE6D" xlink:to="lab_invest_InvestmentSecuritiesClassAxis_6D34DE246487280A78EF00ACB43FFE6D" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentSecuritiesClassDomain_2912A1E70A918D866A8C00ACB43F5C52_terseLabel_en-US" xlink:label="lab_invest_InvestmentSecuritiesClassDomain_2912A1E70A918D866A8C00ACB43F5C52" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Securities Class [Domain]</link:label>
    <link:label id="lab_invest_InvestmentSecuritiesClassDomain_2912A1E70A918D866A8C00ACB43F5C52_label_en-US" xlink:label="lab_invest_InvestmentSecuritiesClassDomain_2912A1E70A918D866A8C00ACB43F5C52" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment Securities Class [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassDomain" xlink:label="loc_invest_InvestmentSecuritiesClassDomain_2912A1E70A918D866A8C00ACB43F5C52" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_2912A1E70A918D866A8C00ACB43F5C52" xlink:to="lab_invest_InvestmentSecuritiesClassDomain_2912A1E70A918D866A8C00ACB43F5C52" xlink:type="arc" />
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_300A8FA59B00F10B988F00ACB4407FE1_terseLabel_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_300A8FA59B00F10B988F00ACB4407FE1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Mortgage-backed Securities, Issued by US Government Sponsored Enterprises [Member]</link:label>
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_300A8FA59B00F10B988F00ACB4407FE1_label_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_300A8FA59B00F10B988F00ACB4407FE1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Mortgage-backed Securities, Issued by US Government Sponsored Enterprises [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_300A8FA59B00F10B988F00ACB4407FE1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_300A8FA59B00F10B988F00ACB4407FE1" xlink:to="lab_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_300A8FA59B00F10B988F00ACB4407FE1" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_48F0E74C163AAAB8769000ACB440D520_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_48F0E74C163AAAB8769000ACB440D520" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities Sold under Agreements to Repurchase [Member]</link:label>
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_48F0E74C163AAAB8769000ACB440D520_label_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_48F0E74C163AAAB8769000ACB440D520" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Sold under Agreements to Repurchase [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_48F0E74C163AAAB8769000ACB440D520" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_48F0E74C163AAAB8769000ACB440D520" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_48F0E74C163AAAB8769000ACB440D520" xlink:type="arc" />
    <link:label id="lab_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF_terseLabel_en-US" xlink:label="lab_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets Pledged to Us [Member]</link:label>
    <link:label id="lab_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF_label_en-US" xlink:label="lab_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets Pledged to Us [Member]</link:label>
    <link:label id="lab_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF_documentation_en-US" xlink:label="lab_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Assets Pledged to Us [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AssetsPledgedtoUsMember" xlink:label="loc_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF" xlink:to="lab_agnc_AssetsPledgedtoUsMember_1C7E8A2A01276FEA710400ACB4418CDF" xlink:type="arc" />
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8_terseLabel_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Offsetting Assets and Liabilities [Line Items]</link:label>
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8_label_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Offsetting Assets and Liabilities [Line Items]</link:label>
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8_documentation_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Line Items] for Offsetting Assets and Liabilities [Table]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8" xlink:to="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_66E97926FBEB409CF1EC00ACB44201F8" xlink:type="arc" />
    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_A7692F6666D0DF9F4BA800ACB4427676_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock_A7692F6666D0DF9F4BA800ACB4427676" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_A7692F6666D0DF9F4BA800ACB4427676_label_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock_A7692F6666D0DF9F4BA800ACB4427676" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_A7692F6666D0DF9F4BA800ACB4427676" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FederalHomeLoanBankStock_A7692F6666D0DF9F4BA800ACB4427676" xlink:to="lab_us-gaap_FederalHomeLoanBankStock_A7692F6666D0DF9F4BA800ACB4427676" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral_C18680C8D6E7A5E2A00700ACB442792B_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral_C18680C8D6E7A5E2A00700ACB442792B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities Pledged as Collateral</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral_C18680C8D6E7A5E2A00700ACB442792B_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral_C18680C8D6E7A5E2A00700ACB442792B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities Pledged as Collateral</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral_C18680C8D6E7A5E2A00700ACB442792B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral_C18680C8D6E7A5E2A00700ACB442792B" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesPledgedAsCollateral_C18680C8D6E7A5E2A00700ACB442792B" xlink:type="arc" />
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalents_822C042D01AFA2355E4500ACB443D53B_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalents_822C042D01AFA2355E4500ACB443D53B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Restricted Cash and Cash Equivalents</link:label>
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalents_822C042D01AFA2355E4500ACB443D53B_label_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalents_822C042D01AFA2355E4500ACB443D53B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Restricted Cash and Cash Equivalents</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_822C042D01AFA2355E4500ACB443D53B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalents_822C042D01AFA2355E4500ACB443D53B" xlink:to="lab_us-gaap_RestrictedCashAndCashEquivalents_822C042D01AFA2355E4500ACB443D53B" xlink:type="arc" />
    <link:label id="lab_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743_terseLabel_en-US" xlink:label="lab_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Restricted Cash and Securities Pledged</link:label>
    <link:label id="lab_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743_label_en-US" xlink:label="lab_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Restricted Cash and Securities Pledged</link:label>
    <link:label id="lab_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743_documentation_en-US" xlink:label="lab_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Restricted Cash and Securities Pledged</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RestrictedCashandSecuritiesPledged" xlink:label="loc_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743" xlink:to="lab_agnc_RestrictedCashandSecuritiesPledged_58561F19165CD9D03A9C00ACB4437743" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueDisclosuresAbstract_5510B60FCC78F40B7D19ADEB678E1445_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresAbstract_E940C96DFE7A5636BC3AD333B9C6851B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Disclosures [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_E940C96DFE7A5636BC3AD333B9C6851B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_E940C96DFE7A5636BC3AD333B9C6851B" xlink:to="lab_us-gaap_FairValueDisclosuresAbstract_E940C96DFE7A5636BC3AD333B9C6851B" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_799AAFAA1762A9663914ADEB678EF0CE_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_39ECAA5651D257C9A9070363803354D8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis</link:label>
    <link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_799AAFAA1762A9663914ADEB678EF0CE_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_39ECAA5651D257C9A9070363803354D8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_39ECAA5651D257C9A9070363803354D8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_39ECAA5651D257C9A9070363803354D8" xlink:to="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_39ECAA5651D257C9A9070363803354D8" xlink:type="arc" />
    <link:label id="lab_us-gaap_SubsequentEventsAbstract_42DA10C9F307BB3E945B00D093562ACF_label_en-US" xlink:label="lab_us-gaap_SubsequentEventsAbstract_42DA10C9F307BB3E945B00D093562ACF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Events [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_42DA10C9F307BB3E945B00D093562ACF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventsAbstract_42DA10C9F307BB3E945B00D093562ACF" xlink:to="lab_us-gaap_SubsequentEventsAbstract_42DA10C9F307BB3E945B00D093562ACF" xlink:type="arc" />
    <link:label id="lab_us-gaap_SubsequentEventTable_0ED8124FA38BEB63F6F300D09356CBE0_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTable_0ED8124FA38BEB63F6F300D09356CBE0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Subsequent Event [Table]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventTable_0ED8124FA38BEB63F6F300D09356CBE0_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTable_0ED8124FA38BEB63F6F300D09356CBE0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_0ED8124FA38BEB63F6F300D09356CBE0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTable_0ED8124FA38BEB63F6F300D09356CBE0" xlink:to="lab_us-gaap_SubsequentEventTable_0ED8124FA38BEB63F6F300D09356CBE0" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementEquityComponentsAxis_C94BE12ED78ECC45941500D0935C4570_terseLabel_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_C94BE12ED78ECC45941500D0935C4570" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Equity Components [Axis]</link:label>
    <link:label id="lab_us-gaap_StatementEquityComponentsAxis_C94BE12ED78ECC45941500D0935C4570_label_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_C94BE12ED78ECC45941500D0935C4570" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Components [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_C94BE12ED78ECC45941500D0935C4570" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_C94BE12ED78ECC45941500D0935C4570" xlink:to="lab_us-gaap_StatementEquityComponentsAxis_C94BE12ED78ECC45941500D0935C4570" xlink:type="arc" />
    <link:label id="lab_us-gaap_EquityComponentDomain_77ED7CD75C40E1CA68DB00D0935C2D9C_terseLabel_en-US" xlink:label="lab_us-gaap_EquityComponentDomain_77ED7CD75C40E1CA68DB00D0935C2D9C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Equity Component [Domain]</link:label>
    <link:label id="lab_us-gaap_EquityComponentDomain_77ED7CD75C40E1CA68DB00D0935C2D9C_label_en-US" xlink:label="lab_us-gaap_EquityComponentDomain_77ED7CD75C40E1CA68DB00D0935C2D9C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Component [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_77ED7CD75C40E1CA68DB00D0935C2D9C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityComponentDomain_77ED7CD75C40E1CA68DB00D0935C2D9C" xlink:to="lab_us-gaap_EquityComponentDomain_77ED7CD75C40E1CA68DB00D0935C2D9C" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockMember_BC70C2D7C6202A0E5DDB00D0935CE861_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_BC70C2D7C6202A0E5DDB00D0935CE861" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock [Member]</link:label>
    <link:label id="lab_us-gaap_CommonStockMember_BC70C2D7C6202A0E5DDB00D0935CE861_label_en-US" xlink:label="lab_us-gaap_CommonStockMember_BC70C2D7C6202A0E5DDB00D0935CE861" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_BC70C2D7C6202A0E5DDB00D0935CE861" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember_BC70C2D7C6202A0E5DDB00D0935CE861" xlink:to="lab_us-gaap_CommonStockMember_BC70C2D7C6202A0E5DDB00D0935CE861" xlink:type="arc" />
    <link:label id="lab_us-gaap_SubsequentEventTypeAxis_3B37B7830DCF31F6D37600D0935C8E49_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis_3B37B7830DCF31F6D37600D0935C8E49" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Subsequent Event Type [Axis]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventTypeAxis_3B37B7830DCF31F6D37600D0935C8E49_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis_3B37B7830DCF31F6D37600D0935C8E49" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event Type [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_3B37B7830DCF31F6D37600D0935C8E49" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_3B37B7830DCF31F6D37600D0935C8E49" xlink:to="lab_us-gaap_SubsequentEventTypeAxis_3B37B7830DCF31F6D37600D0935C8E49" xlink:type="arc" />
    <link:label id="lab_us-gaap_SubsequentEventTypeDomain_04732A5AB43D8B6A100300D0935D6048_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain_04732A5AB43D8B6A100300D0935D6048" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Subsequent Event Type [Domain]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventTypeDomain_04732A5AB43D8B6A100300D0935D6048_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain_04732A5AB43D8B6A100300D0935D6048" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event Type [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_04732A5AB43D8B6A100300D0935D6048" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_04732A5AB43D8B6A100300D0935D6048" xlink:to="lab_us-gaap_SubsequentEventTypeDomain_04732A5AB43D8B6A100300D0935D6048" xlink:type="arc" />
    <link:label id="lab_us-gaap_SubsequentEventMember_FC293394B970AF8C235600D0935D1A54_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventMember_FC293394B970AF8C235600D0935D1A54" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Subsequent Event [Member]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventMember_FC293394B970AF8C235600D0935D1A54_label_en-US" xlink:label="lab_us-gaap_SubsequentEventMember_FC293394B970AF8C235600D0935D1A54" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_FC293394B970AF8C235600D0935D1A54" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventMember_FC293394B970AF8C235600D0935D1A54" xlink:to="lab_us-gaap_SubsequentEventMember_FC293394B970AF8C235600D0935D1A54" xlink:type="arc" />
    <link:label id="lab_us-gaap_SubsequentEventLineItems_40841523CFB074B0DFC300D0935D2B67_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventLineItems_40841523CFB074B0DFC300D0935D2B67" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Subsequent Event [Line Items]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventLineItems_40841523CFB074B0DFC300D0935D2B67_label_en-US" xlink:label="lab_us-gaap_SubsequentEventLineItems_40841523CFB074B0DFC300D0935D2B67" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_40841523CFB074B0DFC300D0935D2B67" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventLineItems_40841523CFB074B0DFC300D0935D2B67" xlink:to="lab_us-gaap_SubsequentEventLineItems_40841523CFB074B0DFC300D0935D2B67" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_362497E1F5563C80DB6400D0935E9156_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared_362497E1F5563C80DB6400D0935E9156" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Dividends, Per Share, Declared</link:label>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_362497E1F5563C80DB6400D0935E9156_label_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared_362497E1F5563C80DB6400D0935E9156" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock, Dividends, Per Share, Declared</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_362497E1F5563C80DB6400D0935E9156" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockDividendsPerShareDeclared_362497E1F5563C80DB6400D0935E9156" xlink:to="lab_us-gaap_CommonStockDividendsPerShareDeclared_362497E1F5563C80DB6400D0935E9156" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D0BC2A17AD7340AA11A000D0935ED112_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D0BC2A17AD7340AA11A000D0935ED112" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Issued During Period, Shares, New Issues</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D0BC2A17AD7340AA11A000D0935ED112_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D0BC2A17AD7340AA11A000D0935ED112" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stock Issued During Period, Shares, New Issues</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D0BC2A17AD7340AA11A000D0935ED112" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D0BC2A17AD7340AA11A000D0935ED112" xlink:to="lab_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D0BC2A17AD7340AA11A000D0935ED112" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues_607EF0F1E84FF9C5804200D0935ECB36_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues_607EF0F1E84FF9C5804200D0935ECB36" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Issued During Period, Value, New Issues</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues_607EF0F1E84FF9C5804200D0935ECB36_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues_607EF0F1E84FF9C5804200D0935ECB36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stock Issued During Period, Value, New Issues</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_607EF0F1E84FF9C5804200D0935ECB36" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_607EF0F1E84FF9C5804200D0935ECB36" xlink:to="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues_607EF0F1E84FF9C5804200D0935ECB36" xlink:type="arc" />
    <link:label id="lab_us-gaap_GainLossOnContractTermination_EBBA4E64E535BC4917ED00D0935E2AC2_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnContractTermination_EBBA4E64E535BC4917ED00D0935E2AC2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gain (Loss) on Contract Termination</link:label>
    <link:label id="lab_us-gaap_GainLossOnContractTermination_EBBA4E64E535BC4917ED00D0935E2AC2_label_en-US" xlink:label="lab_us-gaap_GainLossOnContractTermination_EBBA4E64E535BC4917ED00D0935E2AC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gain (Loss) on Contract Termination</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_EBBA4E64E535BC4917ED00D0935E2AC2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnContractTermination_EBBA4E64E535BC4917ED00D0935E2AC2" xlink:to="lab_us-gaap_GainLossOnContractTermination_EBBA4E64E535BC4917ED00D0935E2AC2" xlink:type="arc" />
    <link:label id="lab_us-gaap_SaleOfStockPricePerShare_616CE7A5967911DC841100D0F8B4B8EF_terseLabel_en-US" xlink:label="lab_us-gaap_SaleOfStockPricePerShare_616CE7A5967911DC841100D0F8B4B8EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sale of Stock, Price Per Share</link:label>
    <link:label id="lab_us-gaap_SaleOfStockPricePerShare_616CE7A5967911DC841100D0F8B4B8EF_label_en-US" xlink:label="lab_us-gaap_SaleOfStockPricePerShare_616CE7A5967911DC841100D0F8B4B8EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sale of Stock, Price Per Share</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_616CE7A5967911DC841100D0F8B4B8EF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SaleOfStockPricePerShare_616CE7A5967911DC841100D0F8B4B8EF" xlink:to="lab_us-gaap_SaleOfStockPricePerShare_616CE7A5967911DC841100D0F8B4B8EF" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_CF261C6FCEC72DE5351122BCF06FC06E_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2468C9F8A8C759ED8EE7A3F41D3C1AAC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Table]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_CF261C6FCEC72DE5351122BCF06FC06E_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2468C9F8A8C759ED8EE7A3F41D3C1AAC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Measurements, Recurring and Nonrecurring [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2468C9F8A8C759ED8EE7A3F41D3C1AAC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2468C9F8A8C759ED8EE7A3F41D3C1AAC" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2468C9F8A8C759ED8EE7A3F41D3C1AAC" xlink:type="arc" />
    <link:label id="lab_us-gaap_FutureMember_FA952FD587AB6FAF18F822BCF06F6299_terseLabel_en-US" xlink:label="lab_us-gaap_FutureMember_B748B20FEE10534FB3602A6D3321F77E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Future [Member]</link:label>
    <link:label id="lab_us-gaap_FutureMember_FA952FD587AB6FAF18F822BCF06F6299_label_en-US" xlink:label="lab_us-gaap_FutureMember_B748B20FEE10534FB3602A6D3321F77E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Future [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_B748B20FEE10534FB3602A6D3321F77E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FutureMember_B748B20FEE10534FB3602A6D3321F77E" xlink:to="lab_us-gaap_FutureMember_B748B20FEE10534FB3602A6D3321F77E" xlink:type="arc" />
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_82D332745DF5174B49F722BCF06F77A8_verboseLabel_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember_4E94A273C2F95EACA618AAAA040A5C7A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">US Treasury Securities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_4E94A273C2F95EACA618AAAA040A5C7A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_USTreasurySecuritiesMember_4E94A273C2F95EACA618AAAA040A5C7A" xlink:to="lab_us-gaap_USTreasurySecuritiesMember_4E94A273C2F95EACA618AAAA040A5C7A" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestRateSwaptionMember_04B0BBF614ED527CD1DA22BCF06FD129_terseLabel_en-US" xlink:label="lab_us-gaap_InterestRateSwaptionMember_5981A58F63095EDD9813BD4A1453DA07" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Swaption [Member]</link:label>
    <link:label id="lab_us-gaap_InterestRateSwaptionMember_04B0BBF614ED527CD1DA22BCF06FD129_label_en-US" xlink:label="lab_us-gaap_InterestRateSwaptionMember_5981A58F63095EDD9813BD4A1453DA07" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Swaption [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_5981A58F63095EDD9813BD4A1453DA07" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestRateSwaptionMember_5981A58F63095EDD9813BD4A1453DA07" xlink:to="lab_us-gaap_InterestRateSwaptionMember_5981A58F63095EDD9813BD4A1453DA07" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestRateSwapMember_EE6D7BEDC73CD9F8E44922BCF06FFDF7_terseLabel_en-US" xlink:label="lab_us-gaap_InterestRateSwapMember_869B510F3CC85EC6B52CE9BD6B052480" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Swap [Member]</link:label>
    <link:label id="lab_us-gaap_InterestRateSwapMember_EE6D7BEDC73CD9F8E44922BCF06FFDF7_label_en-US" xlink:label="lab_us-gaap_InterestRateSwapMember_869B510F3CC85EC6B52CE9BD6B052480" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Swap [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_869B510F3CC85EC6B52CE9BD6B052480" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestRateSwapMember_869B510F3CC85EC6B52CE9BD6B052480" xlink:to="lab_us-gaap_InterestRateSwapMember_869B510F3CC85EC6B52CE9BD6B052480" xlink:type="arc" />
    <link:label id="lab_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_B653379EF66B5A319AE722BCF06F1DF8_terseLabel_en-US" xlink:label="lab_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_9FC4A46FF690548EBD8B83DAFD6EC4BF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Purchases Of TBAs And Forward Settling Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_B653379EF66B5A319AE722BCF06F1DF8_label_en-US" xlink:label="lab_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_9FC4A46FF690548EBD8B83DAFD6EC4BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Purchases Of TBAs And Forward Settling Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_B653379EF66B5A319AE722BCF06F1DF8_documentation_en-US" xlink:label="lab_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_9FC4A46FF690548EBD8B83DAFD6EC4BF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Purchases Of T B As And Forward Settling Agency Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_9FC4A46FF690548EBD8B83DAFD6EC4BF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_9FC4A46FF690548EBD8B83DAFD6EC4BF" xlink:to="lab_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_9FC4A46FF690548EBD8B83DAFD6EC4BF" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeContractTypeDomain_57C276E90CCD56BBA37422BCF06F80B3_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_E148AEA334565A7B8147847F15863594" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivative Contract [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_E148AEA334565A7B8147847F15863594" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_E148AEA334565A7B8147847F15863594" xlink:to="lab_us-gaap_DerivativeContractTypeDomain_E148AEA334565A7B8147847F15863594" xlink:type="arc" />
    <link:label id="lab_us-gaap_BalanceSheetLocationAxis_93F1141F9A38213887B022BCF06FABCF_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis_5E6E9512898B5634BA20A40DC6AE9687" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Balance Sheet Location [Axis]</link:label>
    <link:label id="lab_us-gaap_BalanceSheetLocationAxis_93F1141F9A38213887B022BCF06FABCF_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis_5E6E9512898B5634BA20A40DC6AE9687" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Balance Sheet Location [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_5E6E9512898B5634BA20A40DC6AE9687" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_5E6E9512898B5634BA20A40DC6AE9687" xlink:to="lab_us-gaap_BalanceSheetLocationAxis_5E6E9512898B5634BA20A40DC6AE9687" xlink:type="arc" />
    <link:label id="lab_us-gaap_BalanceSheetLocationDomain_703FABDCF3036C85CA9122BCF06F422A_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_8862B814FABD536C9D8B15F1AA46472A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Balance Sheet Location [Domain]</link:label>
    <link:label id="lab_us-gaap_BalanceSheetLocationDomain_703FABDCF3036C85CA9122BCF06F422A_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_8862B814FABD536C9D8B15F1AA46472A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Balance Sheet Location [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_8862B814FABD536C9D8B15F1AA46472A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_8862B814FABD536C9D8B15F1AA46472A" xlink:to="lab_us-gaap_BalanceSheetLocationDomain_8862B814FABD536C9D8B15F1AA46472A" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_C92CF89D446BDB18E5CA22BCF06F7D95_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_DEE38A9B4A825B24BE3C309477B1480B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivative liabilities, at fair value [Member]</link:label>
    <link:label id="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_C92CF89D446BDB18E5CA22BCF06F7D95_label_en-US" xlink:label="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_DEE38A9B4A825B24BE3C309477B1480B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Financial Instruments, Liabilities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:label="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_DEE38A9B4A825B24BE3C309477B1480B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_DEE38A9B4A825B24BE3C309477B1480B" xlink:to="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_DEE38A9B4A825B24BE3C309477B1480B" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_A6584C03CCFB3614E1E722BCF06F9633_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_4F619B834B105570A68D4F981131A9CC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fair Value by Measurement Frequency [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_A6584C03CCFB3614E1E722BCF06F9633_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_4F619B834B105570A68D4F981131A9CC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Measurement Frequency [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_4F619B834B105570A68D4F981131A9CC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_4F619B834B105570A68D4F981131A9CC" xlink:to="lab_us-gaap_FairValueByMeasurementFrequencyAxis_4F619B834B105570A68D4F981131A9CC" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_D5A91DF97412FF0AD47E22BCF06F7D32_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_1CD9E546467153F4A700EC43159716A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Measurement Frequency [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_D5A91DF97412FF0AD47E22BCF06F7D32_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_1CD9E546467153F4A700EC43159716A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Measurement Frequency [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_1CD9E546467153F4A700EC43159716A4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_1CD9E546467153F4A700EC43159716A4" xlink:to="lab_us-gaap_FairValueMeasurementFrequencyDomain_1CD9E546467153F4A700EC43159716A4" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_8277AF8E0F9A46C89C2E22BCF06F0FFC_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_F1FB85B9C7D851999D704E6F19677FC7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Measurements, Recurring [Member]</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_8277AF8E0F9A46C89C2E22BCF06F0FFC_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_F1FB85B9C7D851999D704E6F19677FC7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Measurements, Recurring [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_F1FB85B9C7D851999D704E6F19677FC7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsRecurringMember_F1FB85B9C7D851999D704E6F19677FC7" xlink:to="lab_us-gaap_FairValueMeasurementsRecurringMember_F1FB85B9C7D851999D704E6F19677FC7" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_AFEC8FCFDD267939C6BC22BCF06F0F45_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F88A36CB0720539F9644704F06CCEF99" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Hierarchy [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_AFEC8FCFDD267939C6BC22BCF06F0F45_label_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F88A36CB0720539F9644704F06CCEF99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Hierarchy [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F88A36CB0720539F9644704F06CCEF99" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F88A36CB0720539F9644704F06CCEF99" xlink:to="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F88A36CB0720539F9644704F06CCEF99" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_80123F06AE50EDC1FB7C22BCF06F7A33_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3C28DD0AC0085708A17E37AEF9522F19" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_80123F06AE50EDC1FB7C22BCF06F7A33_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3C28DD0AC0085708A17E37AEF9522F19" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3C28DD0AC0085708A17E37AEF9522F19" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3C28DD0AC0085708A17E37AEF9522F19" xlink:to="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3C28DD0AC0085708A17E37AEF9522F19" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueInputsLevel1Member_84A8D44B889E87FD294F22BCF06FFC1C_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_3E9537447B2A57FE97E4292028495E83" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 1 [Member]</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel1Member_84A8D44B889E87FD294F22BCF06FFC1C_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_3E9537447B2A57FE97E4292028495E83" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 1 [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_3E9537447B2A57FE97E4292028495E83" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel1Member_3E9537447B2A57FE97E4292028495E83" xlink:to="lab_us-gaap_FairValueInputsLevel1Member_3E9537447B2A57FE97E4292028495E83" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_C1636FBB7102DF666CE022BCF06FA91B_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_C5B88DAD687F54F2BEA1C914C0BBB323" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 2 [Member]</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_C1636FBB7102DF666CE022BCF06FA91B_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_C5B88DAD687F54F2BEA1C914C0BBB323" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 2 [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_C5B88DAD687F54F2BEA1C914C0BBB323" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member_C5B88DAD687F54F2BEA1C914C0BBB323" xlink:to="lab_us-gaap_FairValueInputsLevel2Member_C5B88DAD687F54F2BEA1C914C0BBB323" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueByAssetClassAxis_83A86F76BC852FC821E922BCF06F8554_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis_1EA0ED35A14352F78FDBB0682874AA11" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Asset Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByAssetClassAxis_83A86F76BC852FC821E922BCF06F8554_label_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis_1EA0ED35A14352F78FDBB0682874AA11" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Asset Class [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_1EA0ED35A14352F78FDBB0682874AA11" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_1EA0ED35A14352F78FDBB0682874AA11" xlink:to="lab_us-gaap_FairValueByAssetClassAxis_1EA0ED35A14352F78FDBB0682874AA11" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_1B8E3CCD9C5832F6F67922BCF06F3035_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_72D20FC7E305579FB434149E17B804D2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, by Asset Class [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_1B8E3CCD9C5832F6F67922BCF06F3035_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_72D20FC7E305579FB434149E17B804D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Asset Class [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_72D20FC7E305579FB434149E17B804D2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_72D20FC7E305579FB434149E17B804D2" xlink:to="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_72D20FC7E305579FB434149E17B804D2" xlink:type="arc" />
    <link:label id="lab_agnc_OtherDerivativesMember_29A85A119BF5D5FDCE2922BCF06F04A0_terseLabel_en-US" xlink:label="lab_agnc_OtherDerivativesMember_35D2252456A155A7BB0D8E4C5839888A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other Derivatives [Member]</link:label>
    <link:label id="lab_agnc_OtherDerivativesMember_29A85A119BF5D5FDCE2922BCF06F04A0_label_en-US" xlink:label="lab_agnc_OtherDerivativesMember_35D2252456A155A7BB0D8E4C5839888A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Derivatives [Member]</link:label>
    <link:label id="lab_agnc_OtherDerivativesMember_29A85A119BF5D5FDCE2922BCF06F04A0_documentation_en-US" xlink:label="lab_agnc_OtherDerivativesMember_35D2252456A155A7BB0D8E4C5839888A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Other Derivatives [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_35D2252456A155A7BB0D8E4C5839888A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherDerivativesMember_35D2252456A155A7BB0D8E4C5839888A" xlink:to="lab_agnc_OtherDerivativesMember_35D2252456A155A7BB0D8E4C5839888A" xlink:type="arc" />
    <link:label id="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_B8CF2F9BE43167D8908622BCF06F6A12_verboseLabel_en-US" xlink:label="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_64D7D85C468D5ADAB91FBAA2D4C10B33" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">TBA and Forward Settling Agency Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_64D7D85C468D5ADAB91FBAA2D4C10B33" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_64D7D85C468D5ADAB91FBAA2D4C10B33" xlink:to="lab_agnc_TBAandForwardSettlingAgencySecuritiesMember_64D7D85C468D5ADAB91FBAA2D4C10B33" xlink:type="arc" />
    <link:label id="lab_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_CABFDC5CBCAFD5963DCD22BCF06FE3E0_terseLabel_en-US" xlink:label="lab_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_3EBDBA451C36553E9142BDD2121D8BC1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sale Of TBA And Forward Settling Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_CABFDC5CBCAFD5963DCD22BCF06FE3E0_label_en-US" xlink:label="lab_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_3EBDBA451C36553E9142BDD2121D8BC1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sale Of TBA And Forward Settling Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_CABFDC5CBCAFD5963DCD22BCF06FE3E0_documentation_en-US" xlink:label="lab_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_3EBDBA451C36553E9142BDD2121D8BC1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Sale Of T B A And Forward Settling Agency Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_3EBDBA451C36553E9142BDD2121D8BC1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_3EBDBA451C36553E9142BDD2121D8BC1" xlink:to="lab_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_3EBDBA451C36553E9142BDD2121D8BC1" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_084873F5B04374EC14EE22BCF06FA074_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_2EB3D0C1A91257E9959D9B37CE44493B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value by Liability Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_084873F5B04374EC14EE22BCF06FA074_label_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_2EB3D0C1A91257E9959D9B37CE44493B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liability Class [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_2EB3D0C1A91257E9959D9B37CE44493B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_2EB3D0C1A91257E9959D9B37CE44493B" xlink:to="lab_us-gaap_FairValueByLiabilityClassAxis_2EB3D0C1A91257E9959D9B37CE44493B" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_5BF670F7D58C1C82CEC622BCF06FCF2C_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_CA76767866A45B308E6407797D7F4162" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Liabilities, Measured on Recurring Basis, Unobservable Input Reconciliation, by Liability Class [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_5BF670F7D58C1C82CEC622BCF06FCF2C_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_CA76767866A45B308E6407797D7F4162" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value by Liability Class [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_CA76767866A45B308E6407797D7F4162" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_CA76767866A45B308E6407797D7F4162" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_CA76767866A45B308E6407797D7F4162" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C892E5FAE4611EFC276622BCF06F4E91_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A0AB03BD51454CBA91E4A8837CF1C5E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C892E5FAE4611EFC276622BCF06F4E91_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A0AB03BD51454CBA91E4A8837CF1C5E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A0AB03BD51454CBA91E4A8837CF1C5E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A0AB03BD51454CBA91E4A8837CF1C5E" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A0AB03BD51454CBA91E4A8837CF1C5E" xlink:type="arc" />
    <link:label id="lab_agnc_TransfersBetweenHierarchyLevels_278084EEB4D2BA4ED87E22BCF06FDD3A_terseLabel_en-US" xlink:label="lab_agnc_TransfersBetweenHierarchyLevels_8FC07CEEBA6D504FAAC68239AB2B3EA6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Transfers between hierarchy levels</link:label>
    <link:label id="lab_agnc_TransfersBetweenHierarchyLevels_278084EEB4D2BA4ED87E22BCF06FDD3A_label_en-US" xlink:label="lab_agnc_TransfersBetweenHierarchyLevels_8FC07CEEBA6D504FAAC68239AB2B3EA6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Transfers Between Hierarchy Levels</link:label>
    <link:label id="lab_agnc_TransfersBetweenHierarchyLevels_278084EEB4D2BA4ED87E22BCF06FDD3A_documentation_en-US" xlink:label="lab_agnc_TransfersBetweenHierarchyLevels_8FC07CEEBA6D504FAAC68239AB2B3EA6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Transfers between hierarchy levels</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TransfersBetweenHierarchyLevels" xlink:label="loc_agnc_TransfersBetweenHierarchyLevels_8FC07CEEBA6D504FAAC68239AB2B3EA6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TransfersBetweenHierarchyLevels_8FC07CEEBA6D504FAAC68239AB2B3EA6" xlink:to="lab_agnc_TransfersBetweenHierarchyLevels_8FC07CEEBA6D504FAAC68239AB2B3EA6" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_83B7441573266C57BD6C22BCF06F092A_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CD1A38E7775D550496D39744C47F0667" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Agency securities</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_83B7441573266C57BD6C22BCF06F092A_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CD1A38E7775D550496D39744C47F0667" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instruments, Owned, Mortgages, Mortgage-backed and Asset-backed Securities, at Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CD1A38E7775D550496D39744C47F0667" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CD1A38E7775D550496D39744C47F0667" xlink:to="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CD1A38E7775D550496D39744C47F0667" xlink:type="arc" />
    <link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_444DFCCFBCA75D22643C22BCF06F061B_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_5C309DC6E99956E1809D66820BA5CBEB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Agency securities transferred to consolidated VIEs</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_444DFCCFBCA75D22643C22BCF06F061B_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_5C309DC6E99956E1809D66820BA5CBEB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Variable Interest Entity, Consolidated, Carrying Amount, Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_5C309DC6E99956E1809D66820BA5CBEB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_5C309DC6E99956E1809D66820BA5CBEB" xlink:to="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_5C309DC6E99956E1809D66820BA5CBEB" xlink:type="arc" />
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_66F390D219838DDA828A22BCF06F8FC5_verboseLabel_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue_4E4010DC18CC56FE87FC5D61EF8C1EB2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Non-Agency Securities, at Fair Value</link:label>
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_66F390D219838DDA828A22BCF06F8FC5_label_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue_4E4010DC18CC56FE87FC5D61EF8C1EB2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Non-Agency Securities, at Fair Value</link:label>
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_66F390D219838DDA828A22BCF06F8FC5_documentation_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue_4E4010DC18CC56FE87FC5D61EF8C1EB2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Non-Agency Securities, at Fair Value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NonAgencySecuritiesatFairValue" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_4E4010DC18CC56FE87FC5D61EF8C1EB2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NonAgencySecuritiesatFairValue_4E4010DC18CC56FE87FC5D61EF8C1EB2" xlink:to="lab_agnc_NonAgencySecuritiesatFairValue_4E4010DC18CC56FE87FC5D61EF8C1EB2" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_16A923D057D5D277EDE022BCF06F4692_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F9FFE5BD248F533CBE9E74B2B64013D6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Financial Instruments, Owned, Other, at Fair Value</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_16A923D057D5D277EDE022BCF06F4692_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F9FFE5BD248F533CBE9E74B2B64013D6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instruments, Owned, Other, at Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F9FFE5BD248F533CBE9E74B2B64013D6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F9FFE5BD248F533CBE9E74B2B64013D6" xlink:to="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F9FFE5BD248F533CBE9E74B2B64013D6" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_3B7A72DB4C208D841A0F22BCF06FB631_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_EA51EBB62EFA50D1AD9B5713822F7D42" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">U.S. Treasury securities</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_3B7A72DB4C208D841A0F22BCF06FB631_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_EA51EBB62EFA50D1AD9B5713822F7D42" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instruments, Owned, US Government and Agency Obligations, at Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_EA51EBB62EFA50D1AD9B5713822F7D42" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_EA51EBB62EFA50D1AD9B5713822F7D42" xlink:to="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_EA51EBB62EFA50D1AD9B5713822F7D42" xlink:type="arc" />
    <link:label id="lab_us-gaap_MarketableSecuritiesEquitySecurities_B4ACEC1FA383533AD79E22BCF06FC0DB_verboseLabel_en-US" xlink:label="lab_us-gaap_MarketableSecuritiesEquitySecurities_B3C552122F0F5EE6B8BFC2C143BCD623" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Marketable Securities, Equity Securities</link:label>
    <link:label id="lab_us-gaap_MarketableSecuritiesEquitySecurities_B4ACEC1FA383533AD79E22BCF06FC0DB_label_en-US" xlink:label="lab_us-gaap_MarketableSecuritiesEquitySecurities_B3C552122F0F5EE6B8BFC2C143BCD623" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Marketable Securities, Equity Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MarketableSecuritiesEquitySecurities" xlink:label="loc_us-gaap_MarketableSecuritiesEquitySecurities_B3C552122F0F5EE6B8BFC2C143BCD623" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MarketableSecuritiesEquitySecurities_B3C552122F0F5EE6B8BFC2C143BCD623" xlink:to="lab_us-gaap_MarketableSecuritiesEquitySecurities_B3C552122F0F5EE6B8BFC2C143BCD623" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeAssets_D3B29C03F30AD17838A522BCF06F77A0_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssets_275391BD6D725CA28619F662649309C7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">TBA securities</link:label>
    <link:label id="lab_us-gaap_DerivativeAssets_D3B29C03F30AD17838A522BCF06F77A0_label_en-US" xlink:label="lab_us-gaap_DerivativeAssets_275391BD6D725CA28619F662649309C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Asset</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_275391BD6D725CA28619F662649309C7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAssets_275391BD6D725CA28619F662649309C7" xlink:to="lab_us-gaap_DerivativeAssets_275391BD6D725CA28619F662649309C7" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLiabilities_E3F5D16E09E4F03F436822BCF06F6FAD_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_2E2A81D0691158A3981FF721095278A2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Liability</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilities_E3F5D16E09E4F03F436822BCF06F6FAD_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_2E2A81D0691158A3981FF721095278A2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Liability</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_2E2A81D0691158A3981FF721095278A2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilities_2E2A81D0691158A3981FF721095278A2" xlink:to="lab_us-gaap_DerivativeLiabilities_2E2A81D0691158A3981FF721095278A2" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_4D923B1526438CCB650722BCF06F54C7_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_E3FA8CB734BF5F60810820A80E2EE8F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total assets</link:label>
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_4D923B1526438CCB650722BCF06F54C7_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_E3FA8CB734BF5F60810820A80E2EE8F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets, Fair Value Disclosure</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_E3FA8CB734BF5F60810820A80E2EE8F4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_E3FA8CB734BF5F60810820A80E2EE8F4" xlink:to="lab_us-gaap_AssetsFairValueDisclosure_E3FA8CB734BF5F60810820A80E2EE8F4" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherLongTermDebt_C3DA8FF865D67BEC360622BCF06F5489_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt_23A3981A83815BE19FDA80C86F17F10D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Debt of consolidated variable interest entities, at fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_23A3981A83815BE19FDA80C86F17F10D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLongTermDebt_23A3981A83815BE19FDA80C86F17F10D" xlink:to="lab_us-gaap_OtherLongTermDebt_23A3981A83815BE19FDA80C86F17F10D" xlink:type="arc" />
    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_D28EEE3EE284E3DBC49122BCF06F7DAC_verboseLabel_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_B53874DA1EC25C71830CD7A097D1969B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Obligation to return securities borrowed under reverse repurchase agreements, at fair value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_B53874DA1EC25C71830CD7A097D1969B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_B53874DA1EC25C71830CD7A097D1969B" xlink:to="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_B53874DA1EC25C71830CD7A097D1969B" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_51240E45EAAFEC181B2022BCF06F1E4C_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_FE901FFB55A1580BB4CDB917752B3DFB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest rate swaps</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_51240E45EAAFEC181B2022BCF06F1E4C_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_FE901FFB55A1580BB4CDB917752B3DFB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments Not Designated as Hedging Instruments, Asset, at Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_FE901FFB55A1580BB4CDB917752B3DFB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_FE901FFB55A1580BB4CDB917752B3DFB" xlink:to="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_FE901FFB55A1580BB4CDB917752B3DFB" xlink:type="arc" />
    <link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_E05DB59B9B085972114022BCF06F720A_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_09710044749E58EF9816C43A930B1FA9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total liabilities</link:label>
    <link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_E05DB59B9B085972114022BCF06F720A_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_09710044749E58EF9816C43A930B1FA9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial and Nonfinancial Liabilities, Fair Value Disclosure</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_09710044749E58EF9816C43A930B1FA9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_09710044749E58EF9816C43A930B1FA9" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosure_09710044749E58EF9816C43A930B1FA9" xlink:type="arc" />
    <link:label id="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_F658F2EC5C521128366E00407ABA185A_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_F658F2EC5C521128366E00407ABA185A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">New Accounting Pronouncements or Change in Accounting Principle [Table]</link:label>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_F658F2EC5C521128366E00407ABA185A_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_F658F2EC5C521128366E00407ABA185A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">New Accounting Pronouncements or Change in Accounting Principle [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_F658F2EC5C521128366E00407ABA185A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_F658F2EC5C521128366E00407ABA185A" xlink:to="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_F658F2EC5C521128366E00407ABA185A" xlink:type="arc" />
    <link:label id="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7DFEB7FA7561DC25FF9E00407ABAFAFF_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7DFEB7FA7561DC25FF9E00407ABAFAFF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Adjustments for Change in Accounting Principle [Axis]</link:label>
    <link:label id="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7DFEB7FA7561DC25FF9E00407ABAFAFF_label_en-US" xlink:label="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7DFEB7FA7561DC25FF9E00407ABAFAFF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Adjustments for Change in Accounting Principle [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7DFEB7FA7561DC25FF9E00407ABAFAFF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7DFEB7FA7561DC25FF9E00407ABAFAFF" xlink:to="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7DFEB7FA7561DC25FF9E00407ABAFAFF" xlink:type="arc" />
    <link:label id="lab_us-gaap_ChangeInAccountingPrincipleMember_D2ABAD12AA816689A1E300407ABB7267_terseLabel_en-US" xlink:label="lab_us-gaap_ChangeInAccountingPrincipleMember_D2ABAD12AA816689A1E300407ABB7267" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Adjustments for Change in Accounting Principle [Domain]</link:label>
    <link:label id="lab_us-gaap_ChangeInAccountingPrincipleMember_D2ABAD12AA816689A1E300407ABB7267_label_en-US" xlink:label="lab_us-gaap_ChangeInAccountingPrincipleMember_D2ABAD12AA816689A1E300407ABB7267" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Adjustments for Change in Accounting Principle [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_D2ABAD12AA816689A1E300407ABB7267" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_D2ABAD12AA816689A1E300407ABB7267" xlink:to="lab_us-gaap_ChangeInAccountingPrincipleMember_D2ABAD12AA816689A1E300407ABB7267" xlink:type="arc" />
    <link:label id="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F_terseLabel_en-US" xlink:label="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Discontinuation of Election to Account for Interest Rate Swaps as Designated Cash Flow Hedges [Member]</link:label>
    <link:label id="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F_label_en-US" xlink:label="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Discontinuation of Election to Account for Interest Rate Swaps as Designated Cash Flow Hedges [Member]</link:label>
    <link:label id="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F_documentation_en-US" xlink:label="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Discontinuation of Election to Account for Interest Rate Swaps as Designated Cash Flow Hedges [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F" xlink:to="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_D54A9F8E131AA97C617600407ABBB35F" xlink:type="arc" />
    <link:label id="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_6749496D0D947B06AA9700407ABB2F78_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_6749496D0D947B06AA9700407ABB2F78" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">New Accounting Pronouncements or Change in Accounting Principle [Line Items]</link:label>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_6749496D0D947B06AA9700407ABB2F78_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_6749496D0D947B06AA9700407ABB2F78" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">New Accounting Pronouncements or Change in Accounting Principle [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_6749496D0D947B06AA9700407ABB2F78" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_6749496D0D947B06AA9700407ABB2F78" xlink:to="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_6749496D0D947B06AA9700407ABB2F78" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_5815226F86E0337C419300407ABCB606_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_5815226F86E0337C419300407ABCB606" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_5815226F86E0337C419300407ABCB606_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_5815226F86E0337C419300407ABCB606" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_5815226F86E0337C419300407ABCB606" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_5815226F86E0337C419300407ABCB606" xlink:to="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_5815226F86E0337C419300407ABCB606" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativesPolicyTextBlock_AF5AA6F0CAECDE19DCD500407ABCA566_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_AF5AA6F0CAECDE19DCD500407ABCA566" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivatives, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_DerivativesPolicyTextBlock_AF5AA6F0CAECDE19DCD500407ABCA566_label_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_AF5AA6F0CAECDE19DCD500407ABCA566" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivatives, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_AF5AA6F0CAECDE19DCD500407ABCA566" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesPolicyTextBlock_AF5AA6F0CAECDE19DCD500407ABCA566" xlink:to="lab_us-gaap_DerivativesPolicyTextBlock_AF5AA6F0CAECDE19DCD500407ABCA566" xlink:type="arc" />
    <link:label id="lab_us-gaap_InvestmentPolicyTextBlock_DAB64CE82A783FE622E400407ABC7C66_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_DAB64CE82A783FE622E400407ABC7C66" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_InvestmentPolicyTextBlock_DAB64CE82A783FE622E400407ABC7C66_label_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_DAB64CE82A783FE622E400407ABC7C66" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_DAB64CE82A783FE622E400407ABC7C66" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentPolicyTextBlock_DAB64CE82A783FE622E400407ABC7C66" xlink:to="lab_us-gaap_InvestmentPolicyTextBlock_DAB64CE82A783FE622E400407ABC7C66" xlink:type="arc" />
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C_terseLabel_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Income [Policy Text Block]</link:label>
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C_label_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Income [Policy Text Block]</link:label>
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C_documentation_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Interest Income [Policy Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InterestIncomePolicyTextBlock" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C" xlink:to="lab_agnc_InterestIncomePolicyTextBlock_FDD93FEB354452326BC000407ABC7A7C" xlink:type="arc" />
    <link:label id="lab_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F_terseLabel_en-US" xlink:label="lab_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Management Agreement [Text Block]</link:label>
    <link:label id="lab_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F_label_en-US" xlink:label="lab_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Management Agreement [Text Block]</link:label>
    <link:label id="lab_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F_documentation_en-US" xlink:label="lab_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">MTGE Management Agreement [Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ManagementAgreementTextBlock" xlink:label="loc_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F" xlink:to="lab_agnc_ManagementAgreementTextBlock_AA7BB548337900E1F9C40044B184FA8F" xlink:type="arc" />
    <link:label id="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_FBF15DC407B387655E89ADEB66FE325F_label_en-US" xlink:label="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_B136E6DB95B35037BD38E9A8028B959C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investments, Debt and Equity Securities [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_B136E6DB95B35037BD38E9A8028B959C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_B136E6DB95B35037BD38E9A8028B959C" xlink:to="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_B136E6DB95B35037BD38E9A8028B959C" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_1CADF1B96F76CE21A492ADEB66FE0949_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_F140B24D31BA5A25811A19C2DC258185" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Trading Securities and Other Trading Assets [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_1CADF1B96F76CE21A492ADEB66FE0949_label_en-US" xlink:label="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_F140B24D31BA5A25811A19C2DC258185" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Trading Securities [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_F140B24D31BA5A25811A19C2DC258185" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_F140B24D31BA5A25811A19C2DC258185" xlink:to="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_F140B24D31BA5A25811A19C2DC258185" xlink:type="arc" />
    <link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C0ECEC642FBEE7790255ADEB66FEC7BA_terseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_042D155823A8577AB76A9B16EFEDB1A9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Major Types of Debt and Equity Securities [Axis]</link:label>
    <link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C0ECEC642FBEE7790255ADEB66FEC7BA_label_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_042D155823A8577AB76A9B16EFEDB1A9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Types of Debt and Equity Securities [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_042D155823A8577AB76A9B16EFEDB1A9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_042D155823A8577AB76A9B16EFEDB1A9" xlink:to="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_042D155823A8577AB76A9B16EFEDB1A9" xlink:type="arc" />
    <link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_FB1C08170EA0039E3CB6ADEB66FE5589_terseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_B4949E277FC55F2FB5633C8F10550059" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Major Types of Debt and Equity Securities [Domain]</link:label>
    <link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_FB1C08170EA0039E3CB6ADEB66FE5589_label_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_B4949E277FC55F2FB5633C8F10550059" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Types of Debt and Equity Securities [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_B4949E277FC55F2FB5633C8F10550059" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_B4949E277FC55F2FB5633C8F10550059" xlink:to="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_B4949E277FC55F2FB5633C8F10550059" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementLineItems_F110F743A1C9A9C8B502ADEB66FEE051_terseLabel_en-US" xlink:label="lab_us-gaap_StatementLineItems_6E2FE68161155BF5AEB5B2059B8CFD92" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Statement [Line Items]</link:label>
    <link:label id="lab_us-gaap_StatementLineItems_F110F743A1C9A9C8B502ADEB66FEE051_label_en-US" xlink:label="lab_us-gaap_StatementLineItems_6E2FE68161155BF5AEB5B2059B8CFD92" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_6E2FE68161155BF5AEB5B2059B8CFD92" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementLineItems_6E2FE68161155BF5AEB5B2059B8CFD92" xlink:to="lab_us-gaap_StatementLineItems_6E2FE68161155BF5AEB5B2059B8CFD92" xlink:type="arc" />
    <link:label id="lab_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_8F4D1E6C40FDA9ED1461ADEB66FFEDBA_terseLabel_en-US" xlink:label="lab_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_1006C11CF7E35B42B4E566FEBF139A24" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss) [Roll Forward]</link:label>
    <link:label id="lab_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_8F4D1E6C40FDA9ED1461ADEB66FFEDBA_label_en-US" xlink:label="lab_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_1006C11CF7E35B42B4E566FEBF139A24" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss) [Roll Forward]</link:label>
    <link:label id="lab_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_8F4D1E6C40FDA9ED1461ADEB66FFEDBA_documentation_en-US" xlink:label="lab_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_1006C11CF7E35B42B4E566FEBF139A24" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss) [Roll Forward]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AccumulatedOtherComprehensiveIncomeLossRollForward" xlink:label="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_1006C11CF7E35B42B4E566FEBF139A24" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_1006C11CF7E35B42B4E566FEBF139A24" xlink:to="lab_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_1006C11CF7E35B42B4E566FEBF139A24" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_CA1291C927EA1CDB4C00ADEB66FFF813_periodStartLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_A17F06D319C456DD9D0E868043ED25A4" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Beginning OCI Balance</link:label>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_CA1291C927EA1CDB4C00ADEB66FFF813_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_A17F06D319C456DD9D0E868043ED25A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_A17F06D319C456DD9D0E868043ED25A4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_A17F06D319C456DD9D0E868043ED25A4" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_A17F06D319C456DD9D0E868043ED25A4" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_6170A619053C2C9B7377ADEB66FF0232_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9E7D89D057515A269AF7C9EC32FA20A5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Unrealized Gains and (Losses), Net</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_6170A619053C2C9B7377ADEB66FF0232_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9E7D89D057515A269AF7C9EC32FA20A5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9E7D89D057515A269AF7C9EC32FA20A5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9E7D89D057515A269AF7C9EC32FA20A5" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9E7D89D057515A269AF7C9EC32FA20A5" xlink:type="arc" />
    <link:label id="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_935116E1AECBAE545260ADEB66FF7C2B_verboseLabel_en-US" xlink:label="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_7541654840A053CBAF164900B9595AC7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Reversal of Unrealized (Gains) and Losses, Net on Realization</link:label>
    <link:label id="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_935116E1AECBAE545260ADEB66FF7C2B_label_en-US" xlink:label="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_7541654840A053CBAF164900B9595AC7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income Reclassification Adjustment For Sale Of Security Reversal Of Prior Period Unrealized Gain And Losses On Realization</link:label>
    <link:label id="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_935116E1AECBAE545260ADEB66FF7C2B_documentation_en-US" xlink:label="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_7541654840A053CBAF164900B9595AC7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income Reclassification Adjustment For Sale Of Security Reversal Of Prior Period Unrealized Gain And Losses On Realization</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_7541654840A053CBAF164900B9595AC7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_7541654840A053CBAF164900B9595AC7" xlink:to="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_7541654840A053CBAF164900B9595AC7" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_EF11E11A8187684C8815ADEB66FFCFA0_periodEndLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4DEFD8648324500AB902EE934AC30368" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Ending OCI Balance</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4DEFD8648324500AB902EE934AC30368" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4DEFD8648324500AB902EE934AC30368" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4DEFD8648324500AB902EE934AC30368" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_5F02DFA92A757BCE5F87AF81E0B082AC_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_8CD57A19501B5E679FBBC5CB23743639" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments and Hedging Activities Disclosure [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_8CD57A19501B5E679FBBC5CB23743639" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_8CD57A19501B5E679FBBC5CB23743639" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_8CD57A19501B5E679FBBC5CB23743639" xlink:type="arc" />
    <link:label id="lab_agnc_USGovernmentFuturesSecuritiesTableTextBlock_B6FB1B4677157EE026AFAF8216933134_terseLabel_en-US" xlink:label="lab_agnc_USGovernmentFuturesSecuritiesTableTextBlock_037200214CFE5A74A7A33457C8A9C898" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">US Government Futures Securities [Table Text Block]</link:label>
    <link:label id="lab_agnc_USGovernmentFuturesSecuritiesTableTextBlock_B6FB1B4677157EE026AFAF8216933134_label_en-US" xlink:label="lab_agnc_USGovernmentFuturesSecuritiesTableTextBlock_037200214CFE5A74A7A33457C8A9C898" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">US Government Futures Securities [Table Text Block]</link:label>
    <link:label id="lab_agnc_USGovernmentFuturesSecuritiesTableTextBlock_B6FB1B4677157EE026AFAF8216933134_documentation_en-US" xlink:label="lab_agnc_USGovernmentFuturesSecuritiesTableTextBlock_037200214CFE5A74A7A33457C8A9C898" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">US Government Futures Securities [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_USGovernmentFuturesSecuritiesTableTextBlock" xlink:label="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_037200214CFE5A74A7A33457C8A9C898" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_037200214CFE5A74A7A33457C8A9C898" xlink:to="lab_agnc_USGovernmentFuturesSecuritiesTableTextBlock_037200214CFE5A74A7A33457C8A9C898" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_71DD28F07CB1F36D4AC4AF81E0B04848_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_DF2B118BEBCC527F8B5CFC2009EC74CE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivative and Other Hedging Instruments</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_71DD28F07CB1F36D4AC4AF81E0B04848_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_DF2B118BEBCC527F8B5CFC2009EC74CE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments and Hedging Activities Disclosure [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_DF2B118BEBCC527F8B5CFC2009EC74CE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_DF2B118BEBCC527F8B5CFC2009EC74CE" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_DF2B118BEBCC527F8B5CFC2009EC74CE" xlink:type="arc" />
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Table]</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148_label_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Table]</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Table]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148" xlink:to="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_0F4AF9A5727BF254A6670082D5A90148" xlink:type="arc" />
    <link:label id="lab_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B_terseLabel_en-US" xlink:label="lab_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">J.P. Morgan Securities, LLC [Member]</link:label>
    <link:label id="lab_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B_label_en-US" xlink:label="lab_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">J.P. Morgan Securities, LLC [Member]</link:label>
    <link:label id="lab_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B_documentation_en-US" xlink:label="lab_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">J.P. Morgan Securities, LLC [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_J.P.MorganSecuritiesLLCMember" xlink:label="loc_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B" xlink:to="lab_agnc_J.P.MorganSecuritiesLLCMember_8FD82BAD65A51406E7890082D5ABE38B" xlink:type="arc" />
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Line Items]</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB_label_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Line Items]</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Line Items] for Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Table]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB" xlink:to="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_7A84E6DB7DE4283D1C090082D5ABCDFB" xlink:type="arc" />
    <link:label id="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C_terseLabel_en-US" xlink:label="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Risk Of Repurchase Agreement To Stockholders Equity</link:label>
    <link:label id="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C_label_en-US" xlink:label="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Risk Of Repurchase Agreement To Stockholders Equity</link:label>
    <link:label id="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C_documentation_en-US" xlink:label="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Risk Of Repurchase Agreement To Stockholders Equity</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C" xlink:to="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ABB3090E2BCB4B40555C0082D5AC8C3C" xlink:type="arc" />
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Days to Maturity</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697_label_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements Weighted Average Days To Maturity</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Repurchase Agreements Weighted Average Days To Maturity</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697" xlink:to="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_15DA5AEC749C00AADBE40082D5ACC697" xlink:type="arc" />
    <link:label id="lab_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE_terseLabel_en-US" xlink:label="lab_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Counterparty Exposure, Net</link:label>
    <link:label id="lab_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE_label_en-US" xlink:label="lab_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Counterparty Exposure, Net</link:label>
    <link:label id="lab_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE_documentation_en-US" xlink:label="lab_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the net carrying value of the securities pledged under repurchase agreements, including accrued interest plus any cash or assets on deposit to secure the repurchase obligation, less the amount of the repurchase liability, including accrued interest.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CounterpartyExposureNet" xlink:label="loc_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE" xlink:to="lab_agnc_CounterpartyExposureNet_C0E26DBAA919E4B4C4AB0082D5AC6EAE" xlink:type="arc" />
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements Weighted Average Months To Maturity</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7_label_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements Weighted Average Months To Maturity</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Repurchase Agreements Weighted Average Months To Maturity</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7" xlink:to="lab_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_A2DC5F7DF17D1ABDB76D0082D5AC2FD7" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeTable_7EA4C61C9949580DC4F000D93415144A_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeTable_7EA4C61C9949580DC4F000D93415144A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative [Table]</link:label>
    <link:label id="lab_us-gaap_DerivativeTable_7EA4C61C9949580DC4F000D93415144A_label_en-US" xlink:label="lab_us-gaap_DerivativeTable_7EA4C61C9949580DC4F000D93415144A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_7EA4C61C9949580DC4F000D93415144A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeTable_7EA4C61C9949580DC4F000D93415144A" xlink:to="lab_us-gaap_DerivativeTable_7EA4C61C9949580DC4F000D93415144A" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3_terseLabel_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3_label_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3_documentation_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3" xlink:to="lab_agnc_DerivativeInstrumentsDesignationAxis_E969B72574B917E8015A00D934150DB3" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26_terseLabel_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26_label_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26_documentation_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Derivative Instruments Designation [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26" xlink:to="lab_agnc_DerivativeInstrumentsDesignationDomain_0F1C8F22A2F12401FC4F00D9341A2C26" xlink:type="arc" />
    <link:label id="lab_us-gaap_IncomeStatementLocationAxis_CDE7C241F273E885B5E200D9341B9FE4_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis_CDE7C241F273E885B5E200D9341B9FE4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Income Statement Location [Axis]</link:label>
    <link:label id="lab_us-gaap_IncomeStatementLocationAxis_CDE7C241F273E885B5E200D9341B9FE4_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis_CDE7C241F273E885B5E200D9341B9FE4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Statement Location [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_CDE7C241F273E885B5E200D9341B9FE4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_CDE7C241F273E885B5E200D9341B9FE4" xlink:to="lab_us-gaap_IncomeStatementLocationAxis_CDE7C241F273E885B5E200D9341B9FE4" xlink:type="arc" />
    <link:label id="lab_us-gaap_IncomeStatementLocationDomain_19B744D029361A7FFF1300D9341B5483_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_19B744D029361A7FFF1300D9341B5483" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Income Statement Location [Domain]</link:label>
    <link:label id="lab_us-gaap_IncomeStatementLocationDomain_19B744D029361A7FFF1300D9341B5483_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_19B744D029361A7FFF1300D9341B5483" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Statement Location [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_19B744D029361A7FFF1300D9341B5483" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_19B744D029361A7FFF1300D9341B5483" xlink:to="lab_us-gaap_IncomeStatementLocationDomain_19B744D029361A7FFF1300D9341B5483" xlink:type="arc" />
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781_terseLabel_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781_label_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781_documentation_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781" xlink:to="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_6CC88A9322D56E221E6E00D9341C8781" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039_terseLabel_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039_label_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039_documentation_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039" xlink:to="lab_agnc_DerivativesByMaturityAxis_A5ECEB08464C57C0BE0500D9341D1039" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C_terseLabel_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C_label_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C_documentation_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C" xlink:to="lab_agnc_DerivativesByMaturityDomain_54AA325DBA7E57EA919200D9341D8B7C" xlink:type="arc" />
    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636_terseLabel_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636_label_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636_documentation_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_LessThanOrEqualToOneYearMember" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636" xlink:to="lab_agnc_LessThanOrEqualToOneYearMember_EA804645A17E06C67C8500D9341DD636" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Two Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0_label_en-US" xlink:label="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Two Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0_documentation_en-US" xlink:label="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Two Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:label="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0" xlink:to="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_B61D79F355DAA779C8DA00D9341D82F0" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than Two Years and Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878_label_en-US" xlink:label="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than Two Years and Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878_documentation_en-US" xlink:label="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than Two Years and Less Than or Equal to Three Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:label="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878" xlink:to="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_32A506D5FC57451DD8F100D9341E0878" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC_label_en-US" xlink:label="lab_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC_documentation_en-US" xlink:label="lab_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Three Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" xlink:label="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC" xlink:to="lab_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_28BAD38DD18C4FB5151B00D9341E96AC" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than Three Years and Less Than or Equal to Five Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505_label_en-US" xlink:label="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than Three Years and Less Than or Equal to Five Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505_documentation_en-US" xlink:label="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than Three Years and Less Than or Equal to Five Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505" xlink:to="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_CBEFE70989043B20709800D9341E9505" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than Five Years and Less than or Equal to Seven Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976_label_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than Five Years and Less than or Equal to Seven Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976_documentation_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than Five Years and Less than or Equal to Seven Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:label="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976" xlink:to="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_0851CA1E82A68BFD45E500D9341EE976" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than Seven Years and Less than or Equal to Ten Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A_label_en-US" xlink:label="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than Seven Years and Less than or Equal to Ten Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A_documentation_en-US" xlink:label="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than Seven Years and Less than or Equal to Ten Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" xlink:label="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A" xlink:to="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_C679E87BF6F3B0BF0ACF00D9341EFE1A" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than Ten Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2_label_en-US" xlink:label="lab_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than Ten Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2_documentation_en-US" xlink:label="lab_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than Ten Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanTenYearsMember" xlink:label="loc_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2" xlink:to="lab_agnc_GreaterThanTenYearsMember_885EC6F3D4BFFC075AFD00D9341E37B2" xlink:type="arc" />
    <link:label id="lab_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E_terseLabel_en-US" xlink:label="lab_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Payer Swaption [Member]</link:label>
    <link:label id="lab_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E_label_en-US" xlink:label="lab_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payer Swaption [Member]</link:label>
    <link:label id="lab_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E_documentation_en-US" xlink:label="lab_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Payer Swaption [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PayerSwaptionMember" xlink:label="loc_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E" xlink:to="lab_agnc_PayerSwaptionMember_016FACA559C5D60202F700D9341FD85E" xlink:type="arc" />
    <link:label id="lab_us-gaap_ForwardContractsMember_6F76525C5E2E9D16645800D9341FCDF4_terseLabel_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_6F76525C5E2E9D16645800D9341FCDF4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Forward Contracts [Member]</link:label>
    <link:label id="lab_us-gaap_ForwardContractsMember_6F76525C5E2E9D16645800D9341FCDF4_label_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_6F76525C5E2E9D16645800D9341FCDF4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Forward Contracts [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_6F76525C5E2E9D16645800D9341FCDF4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForwardContractsMember_6F76525C5E2E9D16645800D9341FCDF4" xlink:to="lab_us-gaap_ForwardContractsMember_6F76525C5E2E9D16645800D9341FCDF4" xlink:type="arc" />
    <link:label id="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9_terseLabel_en-US" xlink:label="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Swaps Excluding Forward Starting [Member]</link:label>
    <link:label id="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9_label_en-US" xlink:label="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Swaps Excluding Forward Starting [Member]</link:label>
    <link:label id="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9_documentation_en-US" xlink:label="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Interest Rate Swaps Excluding Forward Starting [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:label="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9" xlink:to="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_2709B5826470BB966EC700D93420CCE9" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792_terseLabel_en-US" xlink:label="lab_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Position [Axis]</link:label>
    <link:label id="lab_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792_label_en-US" xlink:label="lab_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Position [Axis]</link:label>
    <link:label id="lab_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792_documentation_en-US" xlink:label="lab_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative Position [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792" xlink:to="lab_agnc_DerivativePositionAxis_4A7106B423CB272C8AC900D934250792" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162_terseLabel_en-US" xlink:label="lab_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Position [Domain]</link:label>
    <link:label id="lab_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162_label_en-US" xlink:label="lab_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Position [Domain]</link:label>
    <link:label id="lab_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162_documentation_en-US" xlink:label="lab_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative Position [Domain]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162" xlink:to="lab_agnc_DerivativePositionDomain_310D48758C91398C93FE00D93425C162" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_31607E8FF966A867CF4200D9342637DE_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_31607E8FF966A867CF4200D9342637DE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instrument Risk [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_31607E8FF966A867CF4200D9342637DE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_31607E8FF966A867CF4200D9342637DE" xlink:to="lab_us-gaap_DerivativeInstrumentRiskAxis_31607E8FF966A867CF4200D9342637DE" xlink:type="arc" />
    <link:label id="lab_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE_terseLabel_en-US" xlink:label="lab_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gain Loss on Other Debt</link:label>
    <link:label id="lab_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE_label_en-US" xlink:label="lab_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gain Loss on Other Debt</link:label>
    <link:label id="lab_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE_documentation_en-US" xlink:label="lab_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Gain Loss on Other Debt</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE" xlink:to="lab_agnc_GainLossOnOtherDebt_2F4F6E9CD5FBF9DD98F600D9342868BE" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_EC5A6C42C9D203116B1D00D934288874_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_EC5A6C42C9D203116B1D00D934288874" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instruments Not Designated as Hedging Instruments, Gain (Loss), Net</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_EC5A6C42C9D203116B1D00D934288874_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_EC5A6C42C9D203116B1D00D934288874" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments Not Designated as Hedging Instruments, Gain (Loss), Net</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_EC5A6C42C9D203116B1D00D934288874" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_EC5A6C42C9D203116B1D00D934288874" xlink:to="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_EC5A6C42C9D203116B1D00D934288874" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_A88A98A6CADFEC1CA17500D934288860_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount_A88A98A6CADFEC1CA17500D934288860" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Notional Amount</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_A88A98A6CADFEC1CA17500D934288860_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount_A88A98A6CADFEC1CA17500D934288860" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Liability, Notional Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_A88A98A6CADFEC1CA17500D934288860" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilityNotionalAmount_A88A98A6CADFEC1CA17500D934288860" xlink:to="lab_us-gaap_DerivativeLiabilityNotionalAmount_A88A98A6CADFEC1CA17500D934288860" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeAverageFixedInterestRate_64CC74E9279147CE45F400D9342877EA_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAverageFixedInterestRate_64CC74E9279147CE45F400D9342877EA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Average Fixed Pay Rate</link:label>
    <link:label id="lab_us-gaap_DerivativeAverageFixedInterestRate_64CC74E9279147CE45F400D9342877EA_label_en-US" xlink:label="lab_us-gaap_DerivativeAverageFixedInterestRate_64CC74E9279147CE45F400D9342877EA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative, Average Fixed Interest Rate</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_64CC74E9279147CE45F400D9342877EA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAverageFixedInterestRate_64CC74E9279147CE45F400D9342877EA" xlink:to="lab_us-gaap_DerivativeAverageFixedInterestRate_64CC74E9279147CE45F400D9342877EA" xlink:type="arc" />
    <link:label id="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55_terseLabel_en-US" xlink:label="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Derivative Not Designated As Hedging Instruments Receive Rate</link:label>
    <link:label id="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55_label_en-US" xlink:label="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Derivative Not Designated As Hedging Instruments Receive Rate</link:label>
    <link:label id="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55_documentation_en-US" xlink:label="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Interest Rate Derivative Not Designated As Hedging Instruments Receive Rate</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55" xlink:to="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_640CA9C92AF02C470F4C00D934286E55" xlink:type="arc" />
    <link:label id="lab_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267_terseLabel_en-US" xlink:label="lab_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Options At Cost</link:label>
    <link:label id="lab_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267_label_en-US" xlink:label="lab_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Options At Cost</link:label>
    <link:label id="lab_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267_documentation_en-US" xlink:label="lab_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Options At Cost</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267" xlink:to="lab_agnc_OptionsAtCost_9AD028BB98387D3D029500D93429F267" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestRateDerivativesAtFairValueNet_F41EBB95A09BEBDBD90A00D934294A36_terseLabel_en-US" xlink:label="lab_us-gaap_InterestRateDerivativesAtFairValueNet_F41EBB95A09BEBDBD90A00D934294A36" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Derivatives, at Fair Value, Net</link:label>
    <link:label id="lab_us-gaap_InterestRateDerivativesAtFairValueNet_F41EBB95A09BEBDBD90A00D934294A36_label_en-US" xlink:label="lab_us-gaap_InterestRateDerivativesAtFairValueNet_F41EBB95A09BEBDBD90A00D934294A36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Derivatives, at Fair Value, Net</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_F41EBB95A09BEBDBD90A00D934294A36" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestRateDerivativesAtFairValueNet_F41EBB95A09BEBDBD90A00D934294A36" xlink:to="lab_us-gaap_InterestRateDerivativesAtFairValueNet_F41EBB95A09BEBDBD90A00D934294A36" xlink:type="arc" />
    <link:label id="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9_terseLabel_en-US" xlink:label="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash Flow Hedges Derivative Instruments Not Designated As Hedging Instruments Average Months To Expiration</link:label>
    <link:label id="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9_label_en-US" xlink:label="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash Flow Hedges Derivative Instruments Not Designated As Hedging Instruments Average Months To Expiration</link:label>
    <link:label id="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9_documentation_en-US" xlink:label="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Cash Flow Hedges Derivative Instruments Not Designated As Hedging Instruments Average Months To Expiration</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9" xlink:to="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_A0AA9F56C51A0EBA9C4900D93429C3D9" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeAverageVariableInterestRate_B5154D324A8E4B8DDCF200D93429FA63_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAverageVariableInterestRate_B5154D324A8E4B8DDCF200D93429FA63" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Average Receive Rate</link:label>
    <link:label id="lab_us-gaap_DerivativeAverageVariableInterestRate_B5154D324A8E4B8DDCF200D93429FA63_label_en-US" xlink:label="lab_us-gaap_DerivativeAverageVariableInterestRate_B5154D324A8E4B8DDCF200D93429FA63" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative, Average Variable Interest Rate</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeAverageVariableInterestRate" xlink:label="loc_us-gaap_DerivativeAverageVariableInterestRate_B5154D324A8E4B8DDCF200D93429FA63" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAverageVariableInterestRate_B5154D324A8E4B8DDCF200D93429FA63" xlink:to="lab_us-gaap_DerivativeAverageVariableInterestRate_B5154D324A8E4B8DDCF200D93429FA63" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeAverageRemainingMaturity1_DF0B123DB3D85905FC1300D93429218C_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAverageRemainingMaturity1_DF0B123DB3D85905FC1300D93429218C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Average Maturity (Years)</link:label>
    <link:label id="lab_us-gaap_DerivativeAverageRemainingMaturity1_DF0B123DB3D85905FC1300D93429218C_label_en-US" xlink:label="lab_us-gaap_DerivativeAverageRemainingMaturity1_DF0B123DB3D85905FC1300D93429218C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative, Average Remaining Maturity</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_DF0B123DB3D85905FC1300D93429218C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAverageRemainingMaturity1_DF0B123DB3D85905FC1300D93429218C" xlink:to="lab_us-gaap_DerivativeAverageRemainingMaturity1_DF0B123DB3D85905FC1300D93429218C" xlink:type="arc" />
    <link:label id="lab_invest_DerivativeNotionalAmount_010C2AA9A868C42EE3DC00D934293185_terseLabel_en-US" xlink:label="lab_invest_DerivativeNotionalAmount_010C2AA9A868C42EE3DC00D934293185" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Notional Amount</link:label>
    <link:label id="lab_invest_DerivativeNotionalAmount_010C2AA9A868C42EE3DC00D934293185_label_en-US" xlink:label="lab_invest_DerivativeNotionalAmount_010C2AA9A868C42EE3DC00D934293185" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative, Notional Amount</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_010C2AA9A868C42EE3DC00D934293185" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_DerivativeNotionalAmount_010C2AA9A868C42EE3DC00D934293185" xlink:to="lab_invest_DerivativeNotionalAmount_010C2AA9A868C42EE3DC00D934293185" xlink:type="arc" />
    <link:label id="lab_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Forward Start Date</link:label>
    <link:label id="lab_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312_label_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted Average Forward Start Date</link:label>
    <link:label id="lab_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312_documentation_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Weighted Average Forward Start Date</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_WeightedAverageForwardStartDate" xlink:label="loc_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312" xlink:to="lab_agnc_WeightedAverageForwardStartDate_E7A46E9AA833C960BA1300D9342A3312" xlink:type="arc" />
    <link:label id="lab_us-gaap_RangeAxis_92E5E9588F77145FE9DE00EA693FBD7B_terseLabel_en-US" xlink:label="lab_us-gaap_RangeAxis_92E5E9588F77145FE9DE00EA693FBD7B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Range [Axis]</link:label>
    <link:label id="lab_us-gaap_RangeAxis_92E5E9588F77145FE9DE00EA693FBD7B_label_en-US" xlink:label="lab_us-gaap_RangeAxis_92E5E9588F77145FE9DE00EA693FBD7B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Range [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_92E5E9588F77145FE9DE00EA693FBD7B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeAxis_92E5E9588F77145FE9DE00EA693FBD7B" xlink:to="lab_us-gaap_RangeAxis_92E5E9588F77145FE9DE00EA693FBD7B" xlink:type="arc" />
    <link:label id="lab_us-gaap_RangeMember_C23F30E478DBFFFAD28600EA69405C7C_terseLabel_en-US" xlink:label="lab_us-gaap_RangeMember_C23F30E478DBFFFAD28600EA69405C7C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Range [Domain]</link:label>
    <link:label id="lab_us-gaap_RangeMember_C23F30E478DBFFFAD28600EA69405C7C_label_en-US" xlink:label="lab_us-gaap_RangeMember_C23F30E478DBFFFAD28600EA69405C7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Range [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_C23F30E478DBFFFAD28600EA69405C7C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeMember_C23F30E478DBFFFAD28600EA69405C7C" xlink:to="lab_us-gaap_RangeMember_C23F30E478DBFFFAD28600EA69405C7C" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLineItems_5DB4131AFE2052EAE8FE00EA69412F56_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLineItems_5DB4131AFE2052EAE8FE00EA69412F56" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative [Line Items]</link:label>
    <link:label id="lab_us-gaap_DerivativeLineItems_5DB4131AFE2052EAE8FE00EA69412F56_label_en-US" xlink:label="lab_us-gaap_DerivativeLineItems_5DB4131AFE2052EAE8FE00EA69412F56" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_5DB4131AFE2052EAE8FE00EA69412F56" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLineItems_5DB4131AFE2052EAE8FE00EA69412F56" xlink:to="lab_us-gaap_DerivativeLineItems_5DB4131AFE2052EAE8FE00EA69412F56" xlink:type="arc" />
    <link:label id="lab_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA_terseLabel_en-US" xlink:label="lab_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Required Annual Distribution of Taxable Net Income</link:label>
    <link:label id="lab_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA_label_en-US" xlink:label="lab_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Required Annual Distribution of Taxable Net Income</link:label>
    <link:label id="lab_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA_documentation_en-US" xlink:label="lab_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Required Annual Distribution of Taxable Net Income</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RequiredAnnualDistributionOfTaxableNetIncome" xlink:label="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA" xlink:to="lab_agnc_RequiredAnnualDistributionOfTaxableNetIncome_C67065F75CF80AAD0E7700EA6941FCAA" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_949EF1AC8FA57CCE5FB900EA69AE09E2_label_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract_949EF1AC8FA57CCE5FB900EA69AE09E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement of Financial Position [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_949EF1AC8FA57CCE5FB900EA69AE09E2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_949EF1AC8FA57CCE5FB900EA69AE09E2" xlink:to="lab_us-gaap_StatementOfFinancialPositionAbstract_949EF1AC8FA57CCE5FB900EA69AE09E2" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsAbstract_83447725CE7BB495016400EA69AEF6F0_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract_83447725CE7BB495016400EA69AEF6F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets:</link:label>
    <link:label id="lab_us-gaap_AssetsAbstract_83447725CE7BB495016400EA69AEF6F0_label_en-US" xlink:label="lab_us-gaap_AssetsAbstract_83447725CE7BB495016400EA69AEF6F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_83447725CE7BB495016400EA69AEF6F0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsAbstract_83447725CE7BB495016400EA69AEF6F0" xlink:to="lab_us-gaap_AssetsAbstract_83447725CE7BB495016400EA69AEF6F0" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CA91814A1A0993BCEE3E00EA69AEACF6_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CA91814A1A0993BCEE3E00EA69AEACF6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities, at fair value (including pledged securities of $51,356 and $53,055, respectively)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CA91814A1A0993BCEE3E00EA69AEACF6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CA91814A1A0993BCEE3E00EA69AEACF6" xlink:to="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_CA91814A1A0993BCEE3E00EA69AEACF6" xlink:type="arc" />
    <link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_58991DFEDFBAA9CA971800EA69AFA3F5_verboseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_58991DFEDFBAA9CA971800EA69AFA3F5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities transferred to consolidated variable interest entities, at fair value (pledged securities)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_58991DFEDFBAA9CA971800EA69AFA3F5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_58991DFEDFBAA9CA971800EA69AFA3F5" xlink:to="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_58991DFEDFBAA9CA971800EA69AFA3F5" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_E3821398F5BDE57E612000EA69AF1622_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_E3821398F5BDE57E612000EA69AF1622" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Credit risk transfer securities, at fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_E3821398F5BDE57E612000EA69AF1622" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_E3821398F5BDE57E612000EA69AF1622" xlink:to="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_E3821398F5BDE57E612000EA69AF1622" xlink:type="arc" />
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_14EE792A63CDB4A2CE8000EA69AF4F5F_terseLabel_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue_14EE792A63CDB4A2CE8000EA69AF4F5F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Non-Agency securities, at fair value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NonAgencySecuritiesatFairValue" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_14EE792A63CDB4A2CE8000EA69AF4F5F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NonAgencySecuritiesatFairValue_14EE792A63CDB4A2CE8000EA69AF4F5F" xlink:to="lab_agnc_NonAgencySecuritiesatFairValue_14EE792A63CDB4A2CE8000EA69AF4F5F" xlink:type="arc" />
    <link:label id="lab_us-gaap_MarketableSecuritiesEquitySecurities_585C5CB7427946A83F6900EA69AF903A_terseLabel_en-US" xlink:label="lab_us-gaap_MarketableSecuritiesEquitySecurities_585C5CB7427946A83F6900EA69AF903A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">REIT equity securities, at fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MarketableSecuritiesEquitySecurities" xlink:label="loc_us-gaap_MarketableSecuritiesEquitySecurities_585C5CB7427946A83F6900EA69AF903A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MarketableSecuritiesEquitySecurities_585C5CB7427946A83F6900EA69AF903A" xlink:to="lab_us-gaap_MarketableSecuritiesEquitySecurities_585C5CB7427946A83F6900EA69AF903A" xlink:type="arc" />
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_91629C8E37710E950EB300EA69B08533_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_91629C8E37710E950EB300EA69B08533" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash and cash equivalents</link:label>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_91629C8E37710E950EB300EA69B08533_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_91629C8E37710E950EB300EA69B08533" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents, at Carrying Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_91629C8E37710E950EB300EA69B08533" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_91629C8E37710E950EB300EA69B08533" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_91629C8E37710E950EB300EA69B08533" xlink:type="arc" />
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalents_A0BB4FFB440FEEA5349900EA69B0501F_verboseLabel_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalents_A0BB4FFB440FEEA5349900EA69B0501F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Restricted cash and cash equivalents</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_A0BB4FFB440FEEA5349900EA69B0501F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalents_A0BB4FFB440FEEA5349900EA69B0501F" xlink:to="lab_us-gaap_RestrictedCashAndCashEquivalents_A0BB4FFB440FEEA5349900EA69B0501F" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeAssets_D758239C18BCD26AAFC000EA69B0542C_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssets_D758239C18BCD26AAFC000EA69B0542C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative assets, at fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_D758239C18BCD26AAFC000EA69B0542C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAssets_D758239C18BCD26AAFC000EA69B0542C" xlink:to="lab_us-gaap_DerivativeAssets_D758239C18BCD26AAFC000EA69B0542C" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_D9091A1B69C7FD38977400EA69B0BD24_terseLabel_en-US" xlink:label="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_D9091A1B69C7FD38977400EA69B0BD24" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Receivable for investment securities sold (pledged securities)</link:label>
    <link:label id="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_D9091A1B69C7FD38977400EA69B0BD24_label_en-US" xlink:label="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_D9091A1B69C7FD38977400EA69B0BD24" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Receivables from Broker-Dealers and Clearing Organizations</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations" xlink:label="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_D9091A1B69C7FD38977400EA69B0BD24" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_D9091A1B69C7FD38977400EA69B0BD24" xlink:to="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_D9091A1B69C7FD38977400EA69B0BD24" xlink:type="arc" />
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C_verboseLabel_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Receivable under reverse repurchase agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C_label_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C_documentation_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C" xlink:to="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_3BAD5B3DA1741394153A00EA69B02C2C" xlink:type="arc" />
    <link:label id="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_CB9BC58AA6A0E2DD693900EA69B03F97_terseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_CB9BC58AA6A0E2DD693900EA69B03F97" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Goodwill and other intangible assets, net</link:label>
    <link:label id="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_CB9BC58AA6A0E2DD693900EA69B03F97_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_CB9BC58AA6A0E2DD693900EA69B03F97" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Intangible Assets, Net (Including Goodwill)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_CB9BC58AA6A0E2DD693900EA69B03F97" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_CB9BC58AA6A0E2DD693900EA69B03F97" xlink:to="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_CB9BC58AA6A0E2DD693900EA69B03F97" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherAssets_3B81AF84D77E428CD41900EA69B1484D_terseLabel_en-US" xlink:label="lab_us-gaap_OtherAssets_3B81AF84D77E428CD41900EA69B1484D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other assets</link:label>
    <link:label id="lab_us-gaap_OtherAssets_3B81AF84D77E428CD41900EA69B1484D_label_en-US" xlink:label="lab_us-gaap_OtherAssets_3B81AF84D77E428CD41900EA69B1484D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherAssets" xlink:label="loc_us-gaap_OtherAssets_3B81AF84D77E428CD41900EA69B1484D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssets_3B81AF84D77E428CD41900EA69B1484D" xlink:to="lab_us-gaap_OtherAssets_3B81AF84D77E428CD41900EA69B1484D" xlink:type="arc" />
    <link:label id="lab_us-gaap_Assets_C696C657E5C77776445A00EA69B1553C_totalLabel_en-US" xlink:label="lab_us-gaap_Assets_C696C657E5C77776445A00EA69B1553C" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total assets</link:label>
    <link:label id="lab_us-gaap_Assets_C696C657E5C77776445A00EA69B1553C_label_en-US" xlink:label="lab_us-gaap_Assets_C696C657E5C77776445A00EA69B1553C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_C696C657E5C77776445A00EA69B1553C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets_C696C657E5C77776445A00EA69B1553C" xlink:to="lab_us-gaap_Assets_C696C657E5C77776445A00EA69B1553C" xlink:type="arc" />
    <link:label id="lab_us-gaap_LiabilitiesAbstract_707F8D16C7C5AF17D66800EA69B11003_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract_707F8D16C7C5AF17D66800EA69B11003" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Liabilities:</link:label>
    <link:label id="lab_us-gaap_LiabilitiesAbstract_707F8D16C7C5AF17D66800EA69B11003_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract_707F8D16C7C5AF17D66800EA69B11003" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liabilities [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesAbstract" xlink:label="loc_us-gaap_LiabilitiesAbstract_707F8D16C7C5AF17D66800EA69B11003" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAbstract_707F8D16C7C5AF17D66800EA69B11003" xlink:to="lab_us-gaap_LiabilitiesAbstract_707F8D16C7C5AF17D66800EA69B11003" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_28346981DBD1002635C000EA69B1A1D2_verboseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_28346981DBD1002635C000EA69B1A1D2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_28346981DBD1002635C000EA69B1A1D2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_28346981DBD1002635C000EA69B1A1D2" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_28346981DBD1002635C000EA69B1A1D2" xlink:type="arc" />
    <link:label id="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_9357AE0D9140B6BBECFF00EA69B20930_terseLabel_en-US" xlink:label="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_9357AE0D9140B6BBECFF00EA69B20930" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Payable for investment securities purchased</link:label>
    <link:label id="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_9357AE0D9140B6BBECFF00EA69B20930_label_en-US" xlink:label="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_9357AE0D9140B6BBECFF00EA69B20930" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payables to Broker-Dealers and Clearing Organizations</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PayablesToBrokerDealersAndClearingOrganizations" xlink:label="loc_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_9357AE0D9140B6BBECFF00EA69B20930" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_9357AE0D9140B6BBECFF00EA69B20930" xlink:to="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_9357AE0D9140B6BBECFF00EA69B20930" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLiabilities_28E1BCABBBD47892649800EA69B21C15_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_28E1BCABBBD47892649800EA69B21C15" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivative liabilities, at fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_28E1BCABBBD47892649800EA69B21C15" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilities_28E1BCABBBD47892649800EA69B21C15" xlink:to="lab_us-gaap_DerivativeLiabilities_28E1BCABBBD47892649800EA69B21C15" xlink:type="arc" />
    <link:label id="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_3836156C5D0AF42DB6DE00EA69B2A4F7_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_3836156C5D0AF42DB6DE00EA69B2A4F7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends payable</link:label>
    <link:label id="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_3836156C5D0AF42DB6DE00EA69B2A4F7_label_en-US" xlink:label="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_3836156C5D0AF42DB6DE00EA69B2A4F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends Payable</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_3836156C5D0AF42DB6DE00EA69B2A4F7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_3836156C5D0AF42DB6DE00EA69B2A4F7" xlink:to="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_3836156C5D0AF42DB6DE00EA69B2A4F7" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_BBDA7268B6B872F3A1B900EA69B33419_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_BBDA7268B6B872F3A1B900EA69B33419" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accounts payable and other liabilities</link:label>
    <link:label id="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_BBDA7268B6B872F3A1B900EA69B33419_label_en-US" xlink:label="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_BBDA7268B6B872F3A1B900EA69B33419" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounts Payable and Accrued Liabilities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_BBDA7268B6B872F3A1B900EA69B33419" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_BBDA7268B6B872F3A1B900EA69B33419" xlink:to="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_BBDA7268B6B872F3A1B900EA69B33419" xlink:type="arc" />
    <link:label id="lab_us-gaap_Liabilities_DD3E2BAC9406E9E14FA900EA69B39E51_totalLabel_en-US" xlink:label="lab_us-gaap_Liabilities_DD3E2BAC9406E9E14FA900EA69B39E51" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total liabilities</link:label>
    <link:label id="lab_us-gaap_Liabilities_DD3E2BAC9406E9E14FA900EA69B39E51_label_en-US" xlink:label="lab_us-gaap_Liabilities_DD3E2BAC9406E9E14FA900EA69B39E51" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liabilities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_DD3E2BAC9406E9E14FA900EA69B39E51" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Liabilities_DD3E2BAC9406E9E14FA900EA69B39E51" xlink:to="lab_us-gaap_Liabilities_DD3E2BAC9406E9E14FA900EA69B39E51" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_D9C2B15804320CD0FFB800EA69B394B5_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_D9C2B15804320CD0FFB800EA69B394B5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stockholders' equity:</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_D9C2B15804320CD0FFB800EA69B394B5_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_D9C2B15804320CD0FFB800EA69B394B5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stockholders' Equity Attributable to Parent [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_D9C2B15804320CD0FFB800EA69B394B5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityAbstract_D9C2B15804320CD0FFB800EA69B394B5" xlink:to="lab_us-gaap_StockholdersEquityAbstract_D9C2B15804320CD0FFB800EA69B394B5" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">7.750% Series B Cumulative Redeemable Preferred Stock (aggregate liquidation preference of $175)</link:label>
    <link:label id="lab_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005_label_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock B, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005_documentation_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Aggregate par or stated value of issued nonredeemable preferred B stock (or preferred stock B redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within stockholders' equity.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PreferredStockBValueIssued" xlink:label="loc_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005" xlink:to="lab_agnc_PreferredStockBValueIssued_58A82B8B3816592C567F00EA69B31005" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">7.000% Series C Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock (aggregate liquidation preference of $325)</link:label>
    <link:label id="lab_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47_label_en-US" xlink:label="lab_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock C, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47_documentation_en-US" xlink:label="lab_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Aggregate par or stated value of issued nonredeemable preferred C stock (or preferred stock C redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within stockholders' equity.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PreferredStockCValueIssued" xlink:label="loc_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47" xlink:to="lab_agnc_PreferredStockCValueIssued_3F30CDCA954EC16D5B5D00EA69B37A47" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockValue_95057163D629CEAD509B00EA69B35E90_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockValue_95057163D629CEAD509B00EA69B35E90" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Common stock - $0.01 par value; 900 and 600 shares authorized, respectively; 434.1 and 391.3 shares issued and outstanding, respectively</link:label>
    <link:label id="lab_us-gaap_CommonStockValue_95057163D629CEAD509B00EA69B35E90_label_en-US" xlink:label="lab_us-gaap_CommonStockValue_95057163D629CEAD509B00EA69B35E90" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock, Value, Issued</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_95057163D629CEAD509B00EA69B35E90" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockValue_95057163D629CEAD509B00EA69B35E90" xlink:to="lab_us-gaap_CommonStockValue_95057163D629CEAD509B00EA69B35E90" xlink:type="arc" />
    <link:label id="lab_us-gaap_AdditionalPaidInCapital_87A1DD1414F7CB11480800EA69B43A92_terseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital_87A1DD1414F7CB11480800EA69B43A92" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Additional paid-in capital</link:label>
    <link:label id="lab_us-gaap_AdditionalPaidInCapital_87A1DD1414F7CB11480800EA69B43A92_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital_87A1DD1414F7CB11480800EA69B43A92" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Additional Paid in Capital</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_87A1DD1414F7CB11480800EA69B43A92" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapital_87A1DD1414F7CB11480800EA69B43A92" xlink:to="lab_us-gaap_AdditionalPaidInCapital_87A1DD1414F7CB11480800EA69B43A92" xlink:type="arc" />
    <link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_D9F071F605FA258ED61000EA69B44EE9_verboseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit_D9F071F605FA258ED61000EA69B44EE9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Retained deficit</link:label>
    <link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_D9F071F605FA258ED61000EA69B44EE9_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit_D9F071F605FA258ED61000EA69B44EE9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Retained Earnings (Accumulated Deficit)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_D9F071F605FA258ED61000EA69B44EE9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RetainedEarningsAccumulatedDeficit_D9F071F605FA258ED61000EA69B44EE9" xlink:to="lab_us-gaap_RetainedEarningsAccumulatedDeficit_D9F071F605FA258ED61000EA69B44EE9" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5396145C0912DCF8A5E000EA69B4732C_verboseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5396145C0912DCF8A5E000EA69B4732C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Accumulated other comprehensive loss</link:label>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5396145C0912DCF8A5E000EA69B4732C_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5396145C0912DCF8A5E000EA69B4732C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss), Net of Tax</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5396145C0912DCF8A5E000EA69B4732C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5396145C0912DCF8A5E000EA69B4732C" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5396145C0912DCF8A5E000EA69B4732C" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockholdersEquity_B62A5D536D76E79E29C200EA69B44F69_totalLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_B62A5D536D76E79E29C200EA69B44F69" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total stockholders' equity</link:label>
    <link:label id="lab_us-gaap_StockholdersEquity_B62A5D536D76E79E29C200EA69B44F69_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity_B62A5D536D76E79E29C200EA69B44F69" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stockholders' Equity Attributable to Parent</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_B62A5D536D76E79E29C200EA69B44F69" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity_B62A5D536D76E79E29C200EA69B44F69" xlink:to="lab_us-gaap_StockholdersEquity_B62A5D536D76E79E29C200EA69B44F69" xlink:type="arc" />
    <link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_FBDBBBE92442C9EEE5C400EA69B483BB_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_FBDBBBE92442C9EEE5C400EA69B483BB" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total liabilities and stockholders' equity</link:label>
    <link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_FBDBBBE92442C9EEE5C400EA69B483BB_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_FBDBBBE92442C9EEE5C400EA69B483BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liabilities and Equity</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_FBDBBBE92442C9EEE5C400EA69B483BB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_FBDBBBE92442C9EEE5C400EA69B483BB" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquity_FBDBBBE92442C9EEE5C400EA69B483BB" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2F8A2DA65CABC12FB40600D19DE59967_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2F8A2DA65CABC12FB40600D19DE59967" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2F8A2DA65CABC12FB40600D19DE59967_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2F8A2DA65CABC12FB40600D19DE59967" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2F8A2DA65CABC12FB40600D19DE59967" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2F8A2DA65CABC12FB40600D19DE59967" xlink:to="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2F8A2DA65CABC12FB40600D19DE59967" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementClassOfStockAxis_A782C8BBA68B375E4C0F00D19DE6123D_terseLabel_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_A782C8BBA68B375E4C0F00D19DE6123D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Class of Stock [Axis]</link:label>
    <link:label id="lab_us-gaap_StatementClassOfStockAxis_A782C8BBA68B375E4C0F00D19DE6123D_label_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_A782C8BBA68B375E4C0F00D19DE6123D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Class of Stock [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_A782C8BBA68B375E4C0F00D19DE6123D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementClassOfStockAxis_A782C8BBA68B375E4C0F00D19DE6123D" xlink:to="lab_us-gaap_StatementClassOfStockAxis_A782C8BBA68B375E4C0F00D19DE6123D" xlink:type="arc" />
    <link:label id="lab_us-gaap_ClassOfStockDomain_00FA6DC2355CE97D4BC900D19DE6C7E5_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_00FA6DC2355CE97D4BC900D19DE6C7E5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Class of Stock [Domain]</link:label>
    <link:label id="lab_us-gaap_ClassOfStockDomain_00FA6DC2355CE97D4BC900D19DE6C7E5_label_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_00FA6DC2355CE97D4BC900D19DE6C7E5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Class of Stock [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_00FA6DC2355CE97D4BC900D19DE6C7E5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfStockDomain_00FA6DC2355CE97D4BC900D19DE6C7E5" xlink:to="lab_us-gaap_ClassOfStockDomain_00FA6DC2355CE97D4BC900D19DE6C7E5" xlink:type="arc" />
    <link:label id="lab_us-gaap_SeriesAPreferredStockMember_899998EEBD968243BA7A00D19DE613BA_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_899998EEBD968243BA7A00D19DE613BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Series A Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_SeriesAPreferredStockMember_899998EEBD968243BA7A00D19DE613BA_label_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_899998EEBD968243BA7A00D19DE613BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Series A Preferred Stock [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_899998EEBD968243BA7A00D19DE613BA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesAPreferredStockMember_899998EEBD968243BA7A00D19DE613BA" xlink:to="lab_us-gaap_SeriesAPreferredStockMember_899998EEBD968243BA7A00D19DE613BA" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01283AD988E1C67D266400D19DE7FA50_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01283AD988E1C67D266400D19DE7FA50" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01283AD988E1C67D266400D19DE7FA50_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01283AD988E1C67D266400D19DE7FA50" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01283AD988E1C67D266400D19DE7FA50" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01283AD988E1C67D266400D19DE7FA50" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01283AD988E1C67D266400D19DE7FA50" xlink:type="arc" />
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286_terseLabel_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common stock, Value of Shares Approved for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286_label_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common stock, Value of Shares Approved for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286_documentation_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The dollar value amount approved to issue common stock under an At-the-Market Offering program.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286" xlink:to="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_1652C84671D020891AC500D19DE7D286" xlink:type="arc" />
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B_terseLabel_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B_label_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common stock, Value of Shares Remaining for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B_documentation_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The remaining dollar value amount approved to issue common stock under an At-the-Market program</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B" xlink:to="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_5F25B6BE599463F9E61E00D19DE7371B" xlink:type="arc" />
    <link:label id="lab_us-gaap_RepurchaseAgreementsMember_733B7D3CA09C854FCA220F93703BA393_terseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementsMember_733B7D3CA09C854FCA220F93703BA393" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements [Member]</link:label>
    <link:label id="lab_us-gaap_RepurchaseAgreementsMember_733B7D3CA09C854FCA220F93703BA393_label_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementsMember_733B7D3CA09C854FCA220F93703BA393" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_733B7D3CA09C854FCA220F93703BA393" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepurchaseAgreementsMember_733B7D3CA09C854FCA220F93703BA393" xlink:to="lab_us-gaap_RepurchaseAgreementsMember_733B7D3CA09C854FCA220F93703BA393" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_296F368DF5108AAEB9200F93703C5518_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_296F368DF5108AAEB9200F93703C5518" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Asset Class [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_296F368DF5108AAEB9200F93703C5518" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_296F368DF5108AAEB9200F93703C5518" xlink:to="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_296F368DF5108AAEB9200F93703C5518" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsMember_8C97B145725F92B2845A0F93703C2E06_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsMember_8C97B145725F92B2845A0F93703C2E06" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets [Member]</link:label>
    <link:label id="lab_us-gaap_AssetsMember_8C97B145725F92B2845A0F93703C2E06_label_en-US" xlink:label="lab_us-gaap_AssetsMember_8C97B145725F92B2845A0F93703C2E06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsMember" xlink:label="loc_us-gaap_AssetsMember_8C97B145725F92B2845A0F93703C2E06" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsMember_8C97B145725F92B2845A0F93703C2E06" xlink:to="lab_us-gaap_AssetsMember_8C97B145725F92B2845A0F93703C2E06" xlink:type="arc" />
    <link:label id="lab_us-gaap_LiabilityMember_079714EAC8206BFCC86D0F93703C3F82_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilityMember_079714EAC8206BFCC86D0F93703C3F82" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Liability [Member]</link:label>
    <link:label id="lab_us-gaap_LiabilityMember_079714EAC8206BFCC86D0F93703C3F82_label_en-US" xlink:label="lab_us-gaap_LiabilityMember_079714EAC8206BFCC86D0F93703C3F82" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liability [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilityMember" xlink:label="loc_us-gaap_LiabilityMember_079714EAC8206BFCC86D0F93703C3F82" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilityMember_079714EAC8206BFCC86D0F93703C3F82" xlink:to="lab_us-gaap_LiabilityMember_079714EAC8206BFCC86D0F93703C3F82" xlink:type="arc" />
    <link:label id="lab_us-gaap_SwaptionMember_AF5A8C9138D04D9487C60F93703D7FD2_terseLabel_en-US" xlink:label="lab_us-gaap_SwaptionMember_AF5A8C9138D04D9487C60F93703D7FD2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">ERROR in label resolution.</link:label>
    <link:label id="lab_us-gaap_SwaptionMember_AF5A8C9138D04D9487C60F93703D7FD2_label_en-US" xlink:label="lab_us-gaap_SwaptionMember_AF5A8C9138D04D9487C60F93703D7FD2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Swaption [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SwaptionMember" xlink:label="loc_us-gaap_SwaptionMember_AF5A8C9138D04D9487C60F93703D7FD2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SwaptionMember_AF5A8C9138D04D9487C60F93703D7FD2" xlink:to="lab_us-gaap_SwaptionMember_AF5A8C9138D04D9487C60F93703D7FD2" xlink:type="arc" />
    <link:label id="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43_terseLabel_en-US" xlink:label="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gross Amounts of Recognized Assets</link:label>
    <link:label id="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43_label_en-US" xlink:label="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gross Amount of Recognized Assets (Liabilities)</link:label>
    <link:label id="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43_documentation_en-US" xlink:label="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Fair value before effects of master netting arrangements, of a financial asset or liability or other contract and the contract can be net settled by means outside the contract or delivery of an asset or liability.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GrossAmountOfRecognizedAssetsLiabilities" xlink:label="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43" xlink:to="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_542C11139441A85995DA0F93703E3D43" xlink:type="arc" />
    <link:label id="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73_terseLabel_en-US" xlink:label="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gross Amount Offset in the Consolidated Balance Sheets</link:label>
    <link:label id="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73_label_en-US" xlink:label="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gross Amount Offset in the Consolidated Balance Sheets</link:label>
    <link:label id="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73_documentation_en-US" xlink:label="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Fair value before effects of master netting arrangements, of a financial asset or liability or other contract and the contract can be net settled by means outside the contract or delivery of an asset or liability offset in the consolidated balance sheets</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:label="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73" xlink:to="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_D25D013BA41B553380760F93703EBB73" xlink:type="arc" />
    <link:label id="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025_terseLabel_en-US" xlink:label="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net Amounts of Assets Presented in the Consolidated Balance Sheets</link:label>
    <link:label id="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025_label_en-US" xlink:label="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Amount of Assets (Liabilities) Presented on the Balance Sheet</link:label>
    <link:label id="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025_documentation_en-US" xlink:label="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Fair value after effects of master netting arrangements, of a financial asset or liability or other contract and the contract can be net settled by means outside the contract or delivery of an asset or liability.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:label="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025" xlink:to="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_01337DCFB7698E7AFF4A0F93703F0025" xlink:type="arc" />
    <link:label id="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27_negatedTerseLabel_en-US" xlink:label="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Financial Instruments</link:label>
    <link:label id="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27_label_en-US" xlink:label="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gross Amounts of Financial Instruments Not Offset on the Balance Sheet</link:label>
    <link:label id="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27_documentation_en-US" xlink:label="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Fair value of financial asset or liability or other contract elected not to be offset against an obligation to return collateral or right to receive collateral pledged under a master netting arrangement.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" xlink:label="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27" xlink:to="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_5CBB61C1E265704CC7D40F93703FBA27" xlink:type="arc" />
    <link:label id="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE_negatedTerseLabel_en-US" xlink:label="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Collateral Received</link:label>
    <link:label id="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE_label_en-US" xlink:label="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gross Amounts of Cash Collateral Not Offset on the Balance Sheet</link:label>
    <link:label id="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE_documentation_en-US" xlink:label="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Gross Amounts of Cash Collateral Not Offset on the Balance Sheet</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" xlink:label="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE" xlink:to="lab_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_0C05434637BFB9791CF90F93703F29DE" xlink:type="arc" />
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88_terseLabel_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net Amount</link:label>
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88_label_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Amount After Deducting Gross Amounts Not Offset on the Balance Sheet From Net Amount of Assets (Liabilities) Presented on the Balance Sheet</link:label>
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88_documentation_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Net amount after deducting gross amounts not offset on the balance sheet from net amount of assets (liabilities) presented on the balance sheet.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:label="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88" xlink:to="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_7852FE7CC7C9297C9DDB0F93703F0B88" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleofDividendsDeclaredAbstract_57B11EF924016F25AC303ADC6C6DFA69_label_en-US" xlink:label="lab_agnc_ScheduleofDividendsDeclaredAbstract_14EC280AAEEA5F4EABB3213D8ABB474B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Dividends Declared [Abstract]</link:label>
    <link:label id="lab_agnc_ScheduleofDividendsDeclaredAbstract_57B11EF924016F25AC303ADC6C6DFA69_documentation_en-US" xlink:label="lab_agnc_ScheduleofDividendsDeclaredAbstract_14EC280AAEEA5F4EABB3213D8ABB474B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Dividends Declared [Abstract]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleofDividendsDeclaredAbstract" xlink:label="loc_agnc_ScheduleofDividendsDeclaredAbstract_14EC280AAEEA5F4EABB3213D8ABB474B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleofDividendsDeclaredAbstract_14EC280AAEEA5F4EABB3213D8ABB474B" xlink:to="lab_agnc_ScheduleofDividendsDeclaredAbstract_14EC280AAEEA5F4EABB3213D8ABB474B" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredClassBMember_6DC72856CB69B433150B3ADC6C6E1EFF_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredClassBMember_51E04C639F835787844DE73A42066186" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Class B [Member]</link:label>
    <link:label id="lab_us-gaap_PreferredClassBMember_6DC72856CB69B433150B3ADC6C6E1EFF_label_en-US" xlink:label="lab_us-gaap_PreferredClassBMember_51E04C639F835787844DE73A42066186" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Class B [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredClassBMember" xlink:label="loc_us-gaap_PreferredClassBMember_51E04C639F835787844DE73A42066186" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredClassBMember_51E04C639F835787844DE73A42066186" xlink:to="lab_us-gaap_PreferredClassBMember_51E04C639F835787844DE73A42066186" xlink:type="arc" />
    <link:label id="lab_us-gaap_SeriesCPreferredStockMember_3D830504AA7A619E674F3ADC6C6EAFD7_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesCPreferredStockMember_05A6E5562BAC50D787CB7D454816A029" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Series C Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_SeriesCPreferredStockMember_3D830504AA7A619E674F3ADC6C6EAFD7_label_en-US" xlink:label="lab_us-gaap_SeriesCPreferredStockMember_05A6E5562BAC50D787CB7D454816A029" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Series C Preferred Stock [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_05A6E5562BAC50D787CB7D454816A029" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesCPreferredStockMember_05A6E5562BAC50D787CB7D454816A029" xlink:to="lab_us-gaap_SeriesCPreferredStockMember_05A6E5562BAC50D787CB7D454816A029" xlink:type="arc" />
    <link:label id="lab_us-gaap_DividendsPreferredStock_B14E38FE6F994D2345B23ADC6C6ECD35_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsPreferredStock_EF8069845D355088906B74A77187787D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends, Preferred Stock</link:label>
    <link:label id="lab_us-gaap_DividendsPreferredStock_B14E38FE6F994D2345B23ADC6C6ECD35_label_en-US" xlink:label="lab_us-gaap_DividendsPreferredStock_EF8069845D355088906B74A77187787D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends, Preferred Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DividendsPreferredStock" xlink:label="loc_us-gaap_DividendsPreferredStock_EF8069845D355088906B74A77187787D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsPreferredStock_EF8069845D355088906B74A77187787D" xlink:to="lab_us-gaap_DividendsPreferredStock_EF8069845D355088906B74A77187787D" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockDividendRatePerDollarAmount_596C7297F1CF69A4ABDD3ADC6C6E9ED4_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePerDollarAmount_EB694BF550495572BC7146D78BBB1C23" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Dividend Rate, Per-Dollar-Amount</link:label>
    <link:label id="lab_us-gaap_PreferredStockDividendRatePerDollarAmount_596C7297F1CF69A4ABDD3ADC6C6E9ED4_label_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePerDollarAmount_EB694BF550495572BC7146D78BBB1C23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock, Dividend Rate, Per-Dollar-Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:label="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_EB694BF550495572BC7146D78BBB1C23" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_EB694BF550495572BC7146D78BBB1C23" xlink:to="lab_us-gaap_PreferredStockDividendRatePerDollarAmount_EB694BF550495572BC7146D78BBB1C23" xlink:type="arc" />
    <link:label id="lab_us-gaap_DividendsCommonStock_4E0E0A560ED8EF73574A3ADC6C6E3B57_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsCommonStock_C6F1460C675E5240A6396F03D8E3E4EA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends, Common Stock</link:label>
    <link:label id="lab_us-gaap_DividendsCommonStock_4E0E0A560ED8EF73574A3ADC6C6E3B57_label_en-US" xlink:label="lab_us-gaap_DividendsCommonStock_C6F1460C675E5240A6396F03D8E3E4EA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends, Common Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DividendsCommonStock" xlink:label="loc_us-gaap_DividendsCommonStock_C6F1460C675E5240A6396F03D8E3E4EA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsCommonStock_C6F1460C675E5240A6396F03D8E3E4EA" xlink:to="lab_us-gaap_DividendsCommonStock_C6F1460C675E5240A6396F03D8E3E4EA" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareCashPaid_9324BC9F6685C1DBEACC3ADC6C6ED6FA_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareCashPaid_5AEB92ED28CB5C8588728B44045757A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Dividends, Per Share, Cash Paid</link:label>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareCashPaid_9324BC9F6685C1DBEACC3ADC6C6ED6FA_label_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareCashPaid_5AEB92ED28CB5C8588728B44045757A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock, Dividends, Per Share, Cash Paid</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_5AEB92ED28CB5C8588728B44045757A3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockDividendsPerShareCashPaid_5AEB92ED28CB5C8588728B44045757A3" xlink:to="lab_us-gaap_CommonStockDividendsPerShareCashPaid_5AEB92ED28CB5C8588728B44045757A3" xlink:type="arc" />
    <link:label id="lab_agnc_NetIncomeLossPerCommonShareAbstract_3B0B5B9A1139A8BB7E2900EA682BC48A_label_en-US" xlink:label="lab_agnc_NetIncomeLossPerCommonShareAbstract_3B0B5B9A1139A8BB7E2900EA682BC48A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Income (Loss) Per Common Share [Abstract]</link:label>
    <link:label id="lab_agnc_NetIncomeLossPerCommonShareAbstract_3B0B5B9A1139A8BB7E2900EA682BC48A_documentation_en-US" xlink:label="lab_agnc_NetIncomeLossPerCommonShareAbstract_3B0B5B9A1139A8BB7E2900EA682BC48A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Net Income (Loss) Per Common Share [Abstract]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NetIncomeLossPerCommonShareAbstract" xlink:label="loc_agnc_NetIncomeLossPerCommonShareAbstract_3B0B5B9A1139A8BB7E2900EA682BC48A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_3B0B5B9A1139A8BB7E2900EA682BC48A" xlink:to="lab_agnc_NetIncomeLossPerCommonShareAbstract_3B0B5B9A1139A8BB7E2900EA682BC48A" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_0C12C59709EBDC1E9B2500EA682B5944_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_0C12C59709EBDC1E9B2500EA682B5944" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_0C12C59709EBDC1E9B2500EA682B5944_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_0C12C59709EBDC1E9B2500EA682B5944" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_0C12C59709EBDC1E9B2500EA682B5944" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_0C12C59709EBDC1E9B2500EA682B5944" xlink:to="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_0C12C59709EBDC1E9B2500EA682B5944" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerShareDilutedLineItems_4BDFAE975A7BAD5241D100EA682CE20D_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDilutedLineItems_4BDFAE975A7BAD5241D100EA682CE20D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDilutedLineItems_4BDFAE975A7BAD5241D100EA682CE20D_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareDilutedLineItems_4BDFAE975A7BAD5241D100EA682CE20D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareDilutedLineItems" xlink:label="loc_us-gaap_EarningsPerShareDilutedLineItems_4BDFAE975A7BAD5241D100EA682CE20D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_4BDFAE975A7BAD5241D100EA682CE20D" xlink:to="lab_us-gaap_EarningsPerShareDilutedLineItems_4BDFAE975A7BAD5241D100EA682CE20D" xlink:type="arc" />
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_88013ECE50469152D8C900EA682C4A88_verboseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_88013ECE50469152D8C900EA682C4A88" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Basic</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_88013ECE50469152D8C900EA682C4A88_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_88013ECE50469152D8C900EA682C4A88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Basic</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_88013ECE50469152D8C900EA682C4A88" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_88013ECE50469152D8C900EA682C4A88" xlink:to="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_88013ECE50469152D8C900EA682C4A88" xlink:type="arc" />
    <link:label id="lab_us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits_E3683B1E017A4198A8E900EA682DD39B_terseLabel_en-US" xlink:label="lab_us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits_E3683B1E017A4198A8E900EA682DD39B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dilutive Securities, Effect on Basic Earnings Per Share, Options and Restrictive Stock Units</link:label>
    <link:label id="lab_us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits_E3683B1E017A4198A8E900EA682DD39B_label_en-US" xlink:label="lab_us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits_E3683B1E017A4198A8E900EA682DD39B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dilutive Securities, Effect on Basic Earnings Per Share, Options and Restrictive Stock Units</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits" xlink:label="loc_us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits_E3683B1E017A4198A8E900EA682DD39B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits_E3683B1E017A4198A8E900EA682DD39B" xlink:to="lab_us-gaap_AmountOfDilutiveSecuritiesStockOptionsAndRestrictiveStockUnits_E3683B1E017A4198A8E900EA682DD39B" xlink:type="arc" />
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_D6344365153C8CB94CA400EA682D91F2_verboseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_D6344365153C8CB94CA400EA682D91F2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Diluted</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_D6344365153C8CB94CA400EA682D91F2_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_D6344365153C8CB94CA400EA682D91F2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Diluted</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_D6344365153C8CB94CA400EA682D91F2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_D6344365153C8CB94CA400EA682D91F2" xlink:to="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_D6344365153C8CB94CA400EA682D91F2" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_172F5E2AEA719328EC3300EA682DECAE_verboseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_172F5E2AEA719328EC3300EA682DECAE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Net Income (Loss) Available to Common Stockholders, Basic</link:label>
    <link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_172F5E2AEA719328EC3300EA682DECAE_label_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_172F5E2AEA719328EC3300EA682DECAE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Income (Loss) Available to Common Stockholders, Basic</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_172F5E2AEA719328EC3300EA682DECAE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_172F5E2AEA719328EC3300EA682DECAE" xlink:to="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_172F5E2AEA719328EC3300EA682DECAE" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerShareBasic_11E72A65CF767B84D4F500EA682DB8C6_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_11E72A65CF767B84D4F500EA682DB8C6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Basic</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareBasic_11E72A65CF767B84D4F500EA682DB8C6_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_11E72A65CF767B84D4F500EA682DB8C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Basic</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_11E72A65CF767B84D4F500EA682DB8C6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasic_11E72A65CF767B84D4F500EA682DB8C6" xlink:to="lab_us-gaap_EarningsPerShareBasic_11E72A65CF767B84D4F500EA682DB8C6" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_5CF3AAF5A2E65F34E03D00EA682D0BD9_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted_5CF3AAF5A2E65F34E03D00EA682D0BD9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Diluted</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_5CF3AAF5A2E65F34E03D00EA682D0BD9_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted_5CF3AAF5A2E65F34E03D00EA682D0BD9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Diluted</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_5CF3AAF5A2E65F34E03D00EA682D0BD9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareDiluted_5CF3AAF5A2E65F34E03D00EA682D0BD9" xlink:to="lab_us-gaap_EarningsPerShareDiluted_5CF3AAF5A2E65F34E03D00EA682D0BD9" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerShareBasicAndDiluted_7FCA303BC7C82CB0815F00EA682ED15A_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAndDiluted_7FCA303BC7C82CB0815F00EA682ED15A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Basic and Diluted</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareBasicAndDiluted_7FCA303BC7C82CB0815F00EA682ED15A_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAndDiluted_7FCA303BC7C82CB0815F00EA682ED15A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Basic and Diluted</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_7FCA303BC7C82CB0815F00EA682ED15A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDiluted_7FCA303BC7C82CB0815F00EA682ED15A" xlink:to="lab_us-gaap_EarningsPerShareBasicAndDiluted_7FCA303BC7C82CB0815F00EA682ED15A" xlink:type="arc" />
    <link:label id="lab_us-gaap_TitleOfIndividualAxis_654601929C765E973684ADEB679E3F81_terseLabel_en-US" xlink:label="lab_us-gaap_TitleOfIndividualAxis_9E923FDCBFBB5D48B21884C4BD1A10B7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Title of Individual [Axis]</link:label>
    <link:label id="lab_us-gaap_TitleOfIndividualAxis_654601929C765E973684ADEB679E3F81_label_en-US" xlink:label="lab_us-gaap_TitleOfIndividualAxis_9E923FDCBFBB5D48B21884C4BD1A10B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Title of Individual [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_9E923FDCBFBB5D48B21884C4BD1A10B7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TitleOfIndividualAxis_9E923FDCBFBB5D48B21884C4BD1A10B7" xlink:to="lab_us-gaap_TitleOfIndividualAxis_9E923FDCBFBB5D48B21884C4BD1A10B7" xlink:type="arc" />
    <link:label id="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_DCC9833BC0250A2F6444ADEB679EC3EF_terseLabel_en-US" xlink:label="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3A70A67AAD4A5A65AA394A5C22A9675A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Relationship to Entity [Domain]</link:label>
    <link:label id="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_DCC9833BC0250A2F6444ADEB679EC3EF_label_en-US" xlink:label="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3A70A67AAD4A5A65AA394A5C22A9675A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Relationship to Entity [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3A70A67AAD4A5A65AA394A5C22A9675A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3A70A67AAD4A5A65AA394A5C22A9675A" xlink:to="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3A70A67AAD4A5A65AA394A5C22A9675A" xlink:type="arc" />
    <link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_90DFCF351862B2319365ADEB679E0761_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6892B1C806515425B84AB31C28163300" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Related Party [Axis]</link:label>
    <link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_90DFCF351862B2319365ADEB679E0761_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6892B1C806515425B84AB31C28163300" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Related Party [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6892B1C806515425B84AB31C28163300" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6892B1C806515425B84AB31C28163300" xlink:to="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6892B1C806515425B84AB31C28163300" xlink:type="arc" />
    <link:label id="lab_us-gaap_RelatedPartyDomain_BA924E25BC841C52DE58ADEB679ED403_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain_3BA3683FAF76551C8128960BAEB43B77" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Related Party [Domain]</link:label>
    <link:label id="lab_us-gaap_RelatedPartyDomain_BA924E25BC841C52DE58ADEB679ED403_label_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain_3BA3683FAF76551C8128960BAEB43B77" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Related Party [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_3BA3683FAF76551C8128960BAEB43B77" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyDomain_3BA3683FAF76551C8128960BAEB43B77" xlink:to="lab_us-gaap_RelatedPartyDomain_3BA3683FAF76551C8128960BAEB43B77" xlink:type="arc" />
    <link:label id="lab_us-gaap_AwardTypeAxis_0DA5202759D4139081F2ADEB679E40DC_terseLabel_en-US" xlink:label="lab_us-gaap_AwardTypeAxis_7AD0641C1DAA5EE7A7B8538B274D09D1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Award Type [Axis]</link:label>
    <link:label id="lab_us-gaap_AwardTypeAxis_0DA5202759D4139081F2ADEB679E40DC_label_en-US" xlink:label="lab_us-gaap_AwardTypeAxis_7AD0641C1DAA5EE7A7B8538B274D09D1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Award Type [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_7AD0641C1DAA5EE7A7B8538B274D09D1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AwardTypeAxis_7AD0641C1DAA5EE7A7B8538B274D09D1" xlink:to="lab_us-gaap_AwardTypeAxis_7AD0641C1DAA5EE7A7B8538B274D09D1" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_809DA34C35FE2909596CADEB679EC67C_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F3F2CD6D272256D5AEF837D15094081C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Equity Award [Domain]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_809DA34C35FE2909596CADEB679EC67C_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F3F2CD6D272256D5AEF837D15094081C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Award [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F3F2CD6D272256D5AEF837D15094081C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F3F2CD6D272256D5AEF837D15094081C" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F3F2CD6D272256D5AEF837D15094081C" xlink:type="arc" />
    <link:label id="lab_agnc_PledgedAssetsTextBlock_D0EBE0930F3920A12653ADEB68020179_terseLabel_en-US" xlink:label="lab_agnc_PledgedAssetsTextBlock_32005CA20F29599EADD3CB0B21B7BC8E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Pledged Assets</link:label>
    <link:label id="lab_agnc_PledgedAssetsTextBlock_D0EBE0930F3920A12653ADEB68020179_label_en-US" xlink:label="lab_agnc_PledgedAssetsTextBlock_32005CA20F29599EADD3CB0B21B7BC8E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Pledged Assets [Text Block]</link:label>
    <link:label id="lab_agnc_PledgedAssetsTextBlock_D0EBE0930F3920A12653ADEB68020179_documentation_en-US" xlink:label="lab_agnc_PledgedAssetsTextBlock_32005CA20F29599EADD3CB0B21B7BC8E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Pledged Assets [Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PledgedAssetsTextBlock" xlink:label="loc_agnc_PledgedAssetsTextBlock_32005CA20F29599EADD3CB0B21B7BC8E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PledgedAssetsTextBlock_32005CA20F29599EADD3CB0B21B7BC8E" xlink:to="lab_agnc_PledgedAssetsTextBlock_32005CA20F29599EADD3CB0B21B7BC8E" xlink:type="arc" />
    <link:label id="lab_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9_terseLabel_en-US" xlink:label="lab_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Bermudan [Member]</link:label>
    <link:label id="lab_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9_label_en-US" xlink:label="lab_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Bermudan [Member]</link:label>
    <link:label id="lab_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9_documentation_en-US" xlink:label="lab_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Bermudan Swaption [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_BermudanMember" xlink:label="loc_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9" xlink:to="lab_agnc_BermudanMember_6532B7113EB5D681E42D00DAAFB0D6F9" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativesByMaturityDomain_4FBDF4F971EDCAD5DF0400D9312F6F62_verboseLabel_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain_4FBDF4F971EDCAD5DF0400D9312F6F62" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_4FBDF4F971EDCAD5DF0400D9312F6F62" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativesByMaturityDomain_4FBDF4F971EDCAD5DF0400D9312F6F62" xlink:to="lab_agnc_DerivativesByMaturityDomain_4FBDF4F971EDCAD5DF0400D9312F6F62" xlink:type="arc" />
    <link:label id="lab_agnc_OptionsAtCost_CE13CF23BA799CA268DB00D93132D649_verboseLabel_en-US" xlink:label="lab_agnc_OptionsAtCost_CE13CF23BA799CA268DB00D93132D649" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Cost</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_CE13CF23BA799CA268DB00D93132D649" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OptionsAtCost_CE13CF23BA799CA268DB00D93132D649" xlink:to="lab_agnc_OptionsAtCost_CE13CF23BA799CA268DB00D93132D649" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestRateDerivativesAtFairValueNet_1F418CDAED6F6FDAB40800D931320E16_verboseLabel_en-US" xlink:label="lab_us-gaap_InterestRateDerivativesAtFairValueNet_1F418CDAED6F6FDAB40800D931320E16" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_1F418CDAED6F6FDAB40800D931320E16" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestRateDerivativesAtFairValueNet_1F418CDAED6F6FDAB40800D931320E16" xlink:to="lab_us-gaap_InterestRateDerivativesAtFairValueNet_1F418CDAED6F6FDAB40800D931320E16" xlink:type="arc" />
    <link:label id="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_1C4779CDC79B92D45DEC00D93132FEAB_verboseLabel_en-US" xlink:label="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_1C4779CDC79B92D45DEC00D93132FEAB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Average Months to Expiration</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_1C4779CDC79B92D45DEC00D93132FEAB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_1C4779CDC79B92D45DEC00D93132FEAB" xlink:to="lab_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_1C4779CDC79B92D45DEC00D93132FEAB" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_8DD65C66FC150496B42C00D9313398C3_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount_8DD65C66FC150496B42C00D9313398C3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Liability, Notional Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_8DD65C66FC150496B42C00D9313398C3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilityNotionalAmount_8DD65C66FC150496B42C00D9313398C3" xlink:to="lab_us-gaap_DerivativeLiabilityNotionalAmount_8DD65C66FC150496B42C00D9313398C3" xlink:type="arc" />
    <link:label id="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_A1BB28B8306324166B2700D93133C664_verboseLabel_en-US" xlink:label="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_A1BB28B8306324166B2700D93133C664" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Average Receive Rate (LIBOR)</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_A1BB28B8306324166B2700D93133C664" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_A1BB28B8306324166B2700D93133C664" xlink:to="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_A1BB28B8306324166B2700D93133C664" xlink:type="arc" />
    <link:label id="lab_us-gaap_IncomeStatementAbstract_6B1297EBC3AAF89F8C0A00EA69913ECE_label_en-US" xlink:label="lab_us-gaap_IncomeStatementAbstract_6B1297EBC3AAF89F8C0A00EA69913ECE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Statement [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_6B1297EBC3AAF89F8C0A00EA69913ECE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementAbstract_6B1297EBC3AAF89F8C0A00EA69913ECE" xlink:to="lab_us-gaap_IncomeStatementAbstract_6B1297EBC3AAF89F8C0A00EA69913ECE" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementTable_28930F5543822CB6DD5900EA699178D9_terseLabel_en-US" xlink:label="lab_us-gaap_StatementTable_28930F5543822CB6DD5900EA699178D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Statement [Table]</link:label>
    <link:label id="lab_us-gaap_StatementTable_28930F5543822CB6DD5900EA699178D9_label_en-US" xlink:label="lab_us-gaap_StatementTable_28930F5543822CB6DD5900EA699178D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_28930F5543822CB6DD5900EA699178D9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementTable_28930F5543822CB6DD5900EA699178D9" xlink:to="lab_us-gaap_StatementTable_28930F5543822CB6DD5900EA699178D9" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementScenarioAxis_F582F620430768A1398C00EA6992FF87_terseLabel_en-US" xlink:label="lab_us-gaap_StatementScenarioAxis_F582F620430768A1398C00EA6992FF87" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Scenario [Axis]</link:label>
    <link:label id="lab_us-gaap_StatementScenarioAxis_F582F620430768A1398C00EA6992FF87_label_en-US" xlink:label="lab_us-gaap_StatementScenarioAxis_F582F620430768A1398C00EA6992FF87" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Scenario [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_F582F620430768A1398C00EA6992FF87" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementScenarioAxis_F582F620430768A1398C00EA6992FF87" xlink:to="lab_us-gaap_StatementScenarioAxis_F582F620430768A1398C00EA6992FF87" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScenarioUnspecifiedDomain_B0D8092E10710B33E46E00EA6992698E_terseLabel_en-US" xlink:label="lab_us-gaap_ScenarioUnspecifiedDomain_B0D8092E10710B33E46E00EA6992698E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Scenario, Unspecified [Domain]</link:label>
    <link:label id="lab_us-gaap_ScenarioUnspecifiedDomain_B0D8092E10710B33E46E00EA6992698E_label_en-US" xlink:label="lab_us-gaap_ScenarioUnspecifiedDomain_B0D8092E10710B33E46E00EA6992698E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Scenario, Unspecified [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_B0D8092E10710B33E46E00EA6992698E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_B0D8092E10710B33E46E00EA6992698E" xlink:to="lab_us-gaap_ScenarioUnspecifiedDomain_B0D8092E10710B33E46E00EA6992698E" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_B9524C3CFE0BE2155E6D00EA699238F1_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared_B9524C3CFE0BE2155E6D00EA699238F1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends declared per common share</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_B9524C3CFE0BE2155E6D00EA699238F1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockDividendsPerShareDeclared_B9524C3CFE0BE2155E6D00EA699238F1" xlink:to="lab_us-gaap_CommonStockDividendsPerShareDeclared_B9524C3CFE0BE2155E6D00EA699238F1" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestIncomeExpenseNetAbstract_E232D7DB2875B18CA62700EA6992D54F_terseLabel_en-US" xlink:label="lab_us-gaap_InterestIncomeExpenseNetAbstract_E232D7DB2875B18CA62700EA6992D54F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest income:</link:label>
    <link:label id="lab_us-gaap_InterestIncomeExpenseNetAbstract_E232D7DB2875B18CA62700EA6992D54F_label_en-US" xlink:label="lab_us-gaap_InterestIncomeExpenseNetAbstract_E232D7DB2875B18CA62700EA6992D54F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Income (Expense), Net [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestIncomeExpenseNetAbstract" xlink:label="loc_us-gaap_InterestIncomeExpenseNetAbstract_E232D7DB2875B18CA62700EA6992D54F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_E232D7DB2875B18CA62700EA6992D54F" xlink:to="lab_us-gaap_InterestIncomeExpenseNetAbstract_E232D7DB2875B18CA62700EA6992D54F" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestIncomeSecuritiesMortgageBacked_C98A7434444AC82044DF00EA699316ED_verboseLabel_en-US" xlink:label="lab_us-gaap_InterestIncomeSecuritiesMortgageBacked_C98A7434444AC82044DF00EA699316ED" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest income</link:label>
    <link:label id="lab_us-gaap_InterestIncomeSecuritiesMortgageBacked_C98A7434444AC82044DF00EA699316ED_label_en-US" xlink:label="lab_us-gaap_InterestIncomeSecuritiesMortgageBacked_C98A7434444AC82044DF00EA699316ED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Income, Securities, Mortgage Backed</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_C98A7434444AC82044DF00EA699316ED" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_C98A7434444AC82044DF00EA699316ED" xlink:to="lab_us-gaap_InterestIncomeSecuritiesMortgageBacked_C98A7434444AC82044DF00EA699316ED" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestExpense_AE62A614DD82EF00379500EA699385FC_verboseLabel_en-US" xlink:label="lab_us-gaap_InterestExpense_AE62A614DD82EF00379500EA699385FC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest expense</link:label>
    <link:label id="lab_us-gaap_InterestExpense_AE62A614DD82EF00379500EA699385FC_label_en-US" xlink:label="lab_us-gaap_InterestExpense_AE62A614DD82EF00379500EA699385FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Expense</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_AE62A614DD82EF00379500EA699385FC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestExpense_AE62A614DD82EF00379500EA699385FC" xlink:to="lab_us-gaap_InterestExpense_AE62A614DD82EF00379500EA699385FC" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestIncomeExpenseNet_E3D92BD6049AED9D1C8F00EA6993093D_totalLabel_en-US" xlink:label="lab_us-gaap_InterestIncomeExpenseNet_E3D92BD6049AED9D1C8F00EA6993093D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net interest income</link:label>
    <link:label id="lab_us-gaap_InterestIncomeExpenseNet_E3D92BD6049AED9D1C8F00EA6993093D_label_en-US" xlink:label="lab_us-gaap_InterestIncomeExpenseNet_E3D92BD6049AED9D1C8F00EA6993093D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Income (Expense), Net</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestIncomeExpenseNet" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_E3D92BD6049AED9D1C8F00EA6993093D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_E3D92BD6049AED9D1C8F00EA6993093D" xlink:to="lab_us-gaap_InterestIncomeExpenseNet_E3D92BD6049AED9D1C8F00EA6993093D" xlink:type="arc" />
    <link:label id="lab_us-gaap_NoninterestIncomeAbstract_9A30FC03414F8D66793500EA699334B3_verboseLabel_en-US" xlink:label="lab_us-gaap_NoninterestIncomeAbstract_9A30FC03414F8D66793500EA699334B3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Other gain (loss), net:</link:label>
    <link:label id="lab_us-gaap_NoninterestIncomeAbstract_9A30FC03414F8D66793500EA699334B3_label_en-US" xlink:label="lab_us-gaap_NoninterestIncomeAbstract_9A30FC03414F8D66793500EA699334B3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Noninterest Income [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NoninterestIncomeAbstract" xlink:label="loc_us-gaap_NoninterestIncomeAbstract_9A30FC03414F8D66793500EA699334B3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_9A30FC03414F8D66793500EA699334B3" xlink:to="lab_us-gaap_NoninterestIncomeAbstract_9A30FC03414F8D66793500EA699334B3" xlink:type="arc" />
    <link:label id="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7FDB8EF17D24B13730D300EA6994B081_verboseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7FDB8EF17D24B13730D300EA6994B081" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Gain (loss) on sale of investment securities, net</link:label>
    <link:label id="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7FDB8EF17D24B13730D300EA6994B081_label_en-US" xlink:label="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7FDB8EF17D24B13730D300EA6994B081" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gain (Loss) on Sales of Mortgage Backed Securities (MBS)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7FDB8EF17D24B13730D300EA6994B081" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7FDB8EF17D24B13730D300EA6994B081" xlink:to="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7FDB8EF17D24B13730D300EA6994B081" xlink:type="arc" />
    <link:label id="lab_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395_terseLabel_en-US" xlink:label="lab_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unrealized gain (loss) on investment securities measured at fair value through net income, net</link:label>
    <link:label id="lab_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395_label_en-US" xlink:label="lab_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Unrealized gain (loss) on investment securities measured at fair value through net income, net</link:label>
    <link:label id="lab_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395_documentation_en-US" xlink:label="lab_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Unrealized gain (loss) on investment securities measured at fair value through net income, net</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395" xlink:to="lab_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_67B86DA286F505907D2600EA69943395" xlink:type="arc" />
    <link:label id="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0_verboseLabel_en-US" xlink:label="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Gain (loss) on derivative instruments and other securities, net</link:label>
    <link:label id="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0_label_en-US" xlink:label="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gain (loss) on derivative instruments and other securities, net</link:label>
    <link:label id="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0_documentation_en-US" xlink:label="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Gain (loss) on derivative instruments and other securities, net</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0" xlink:to="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_2D30B482B76AFD2994BB00EA6994F9A0" xlink:type="arc" />
    <link:label id="lab_us-gaap_ManagementFeesRevenue_A05FA67594B6997CBA5800EA69948078_verboseLabel_en-US" xlink:label="lab_us-gaap_ManagementFeesRevenue_A05FA67594B6997CBA5800EA69948078" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Management fee income</link:label>
    <link:label id="lab_us-gaap_ManagementFeesRevenue_A05FA67594B6997CBA5800EA69948078_label_en-US" xlink:label="lab_us-gaap_ManagementFeesRevenue_A05FA67594B6997CBA5800EA69948078" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Management Fees Revenue</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ManagementFeesRevenue" xlink:label="loc_us-gaap_ManagementFeesRevenue_A05FA67594B6997CBA5800EA69948078" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ManagementFeesRevenue_A05FA67594B6997CBA5800EA69948078" xlink:to="lab_us-gaap_ManagementFeesRevenue_A05FA67594B6997CBA5800EA69948078" xlink:type="arc" />
    <link:label id="lab_us-gaap_NoninterestIncome_6D92DF4753E4DA963CA400EA6994C541_totalLabel_en-US" xlink:label="lab_us-gaap_NoninterestIncome_6D92DF4753E4DA963CA400EA6994C541" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total other gain (loss), net:</link:label>
    <link:label id="lab_us-gaap_NoninterestIncome_6D92DF4753E4DA963CA400EA6994C541_label_en-US" xlink:label="lab_us-gaap_NoninterestIncome_6D92DF4753E4DA963CA400EA6994C541" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Noninterest Income</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NoninterestIncome" xlink:label="loc_us-gaap_NoninterestIncome_6D92DF4753E4DA963CA400EA6994C541" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoninterestIncome_6D92DF4753E4DA963CA400EA6994C541" xlink:to="lab_us-gaap_NoninterestIncome_6D92DF4753E4DA963CA400EA6994C541" xlink:type="arc" />
    <link:label id="lab_us-gaap_NoninterestExpenseAbstract_DE82E6F282166988C5CE00EA69949396_verboseLabel_en-US" xlink:label="lab_us-gaap_NoninterestExpenseAbstract_DE82E6F282166988C5CE00EA69949396" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Expenses:</link:label>
    <link:label id="lab_us-gaap_NoninterestExpenseAbstract_DE82E6F282166988C5CE00EA69949396_label_en-US" xlink:label="lab_us-gaap_NoninterestExpenseAbstract_DE82E6F282166988C5CE00EA69949396" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Noninterest Expense [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NoninterestExpenseAbstract" xlink:label="loc_us-gaap_NoninterestExpenseAbstract_DE82E6F282166988C5CE00EA69949396" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_DE82E6F282166988C5CE00EA69949396" xlink:to="lab_us-gaap_NoninterestExpenseAbstract_DE82E6F282166988C5CE00EA69949396" xlink:type="arc" />
    <link:label id="lab_us-gaap_LaborAndRelatedExpense_0961E63C92B26068C19000EA69959591_verboseLabel_en-US" xlink:label="lab_us-gaap_LaborAndRelatedExpense_0961E63C92B26068C19000EA69959591" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Compensation and benefits</link:label>
    <link:label id="lab_us-gaap_LaborAndRelatedExpense_0961E63C92B26068C19000EA69959591_label_en-US" xlink:label="lab_us-gaap_LaborAndRelatedExpense_0961E63C92B26068C19000EA69959591" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Labor and Related Expense</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LaborAndRelatedExpense" xlink:label="loc_us-gaap_LaborAndRelatedExpense_0961E63C92B26068C19000EA69959591" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LaborAndRelatedExpense_0961E63C92B26068C19000EA69959591" xlink:to="lab_us-gaap_LaborAndRelatedExpense_0961E63C92B26068C19000EA69959591" xlink:type="arc" />
    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpense_3C384B3341A93116F3C800EA69956BF8_verboseLabel_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpense_3C384B3341A93116F3C800EA69956BF8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Other operating expense</link:label>
    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpense_3C384B3341A93116F3C800EA69956BF8_label_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpense_3C384B3341A93116F3C800EA69956BF8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">General and Administrative Expense</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_3C384B3341A93116F3C800EA69956BF8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GeneralAndAdministrativeExpense_3C384B3341A93116F3C800EA69956BF8" xlink:to="lab_us-gaap_GeneralAndAdministrativeExpense_3C384B3341A93116F3C800EA69956BF8" xlink:type="arc" />
    <link:label id="lab_us-gaap_OperatingExpenses_54A42733E881060FF02500EA699578F9_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingExpenses_54A42733E881060FF02500EA699578F9" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total operating expense</link:label>
    <link:label id="lab_us-gaap_OperatingExpenses_54A42733E881060FF02500EA699578F9_label_en-US" xlink:label="lab_us-gaap_OperatingExpenses_54A42733E881060FF02500EA699578F9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Operating Expenses</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_54A42733E881060FF02500EA699578F9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpenses_54A42733E881060FF02500EA699578F9" xlink:to="lab_us-gaap_OperatingExpenses_54A42733E881060FF02500EA699578F9" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetIncomeLoss_CBAE4AFE5F412D0C2E4000EA69951A80_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_CBAE4AFE5F412D0C2E4000EA69951A80" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net income</link:label>
    <link:label id="lab_us-gaap_NetIncomeLoss_CBAE4AFE5F412D0C2E4000EA69951A80_label_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_CBAE4AFE5F412D0C2E4000EA69951A80" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Income (Loss) Attributable to Parent</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_CBAE4AFE5F412D0C2E4000EA69951A80" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLoss_CBAE4AFE5F412D0C2E4000EA69951A80" xlink:to="lab_us-gaap_NetIncomeLoss_CBAE4AFE5F412D0C2E4000EA69951A80" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact_FF3AEFB8E5894335E7B800EA69967B2F_verboseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact_FF3AEFB8E5894335E7B800EA69967B2F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Dividend on preferred stock</link:label>
    <link:label id="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact_FF3AEFB8E5894335E7B800EA69967B2F_label_en-US" xlink:label="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact_FF3AEFB8E5894335E7B800EA69967B2F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock Dividends, Income Statement Impact</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_FF3AEFB8E5894335E7B800EA69967B2F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_FF3AEFB8E5894335E7B800EA69967B2F" xlink:to="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact_FF3AEFB8E5894335E7B800EA69967B2F" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_E5C7C1E19F3B8F63457200EA69962429_totalLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_E5C7C1E19F3B8F63457200EA69962429" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net income available to common stockholders</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_E5C7C1E19F3B8F63457200EA69962429" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_E5C7C1E19F3B8F63457200EA69962429" xlink:to="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_E5C7C1E19F3B8F63457200EA69962429" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_E541A0DDB0EB059B595000EA6996A5C2_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_E541A0DDB0EB059B595000EA6996A5C2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Other comprehensive income (loss):</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_E541A0DDB0EB059B595000EA6996A5C2_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_E541A0DDB0EB059B595000EA6996A5C2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income (Loss), Net of Tax [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_E541A0DDB0EB059B595000EA6996A5C2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_E541A0DDB0EB059B595000EA6996A5C2" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_E541A0DDB0EB059B595000EA6996A5C2" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_778BD597A1755827BAFE00EA6996BEC4_negatedLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_778BD597A1755827BAFE00EA6996BEC4" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Unrealized gain (loss) on available-for-sale securities, net</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_778BD597A1755827BAFE00EA6996BEC4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_778BD597A1755827BAFE00EA6996BEC4" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_778BD597A1755827BAFE00EA6996BEC4" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_A0DA5532FD7790388CBD00EA69978779_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_A0DA5532FD7790388CBD00EA69978779" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Unrealized gain on derivative instruments, net</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_A0DA5532FD7790388CBD00EA69978779_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_A0DA5532FD7790388CBD00EA69978779" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income (Loss), Unrealized Gain (Loss) on Derivatives Arising During Period, Net of Tax</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_A0DA5532FD7790388CBD00EA69978779" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_A0DA5532FD7790388CBD00EA69978779" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_A0DA5532FD7790388CBD00EA69978779" xlink:type="arc" />
    <link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_5C8D42352AD89BCF66A800EA6997F99B_totalLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax_5C8D42352AD89BCF66A800EA6997F99B" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Comprehensive income (loss)</link:label>
    <link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_5C8D42352AD89BCF66A800EA6997F99B_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax_5C8D42352AD89BCF66A800EA6997F99B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Comprehensive Income (Loss), Net of Tax, Attributable to Parent</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_5C8D42352AD89BCF66A800EA6997F99B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_5C8D42352AD89BCF66A800EA6997F99B" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTax_5C8D42352AD89BCF66A800EA6997F99B" xlink:type="arc" />
    <link:label id="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33_totalLabel_en-US" xlink:label="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Comprehensive income (loss) available (attributable) to common stockholders</link:label>
    <link:label id="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33_label_en-US" xlink:label="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Comprehensive income available to common shareholders</link:label>
    <link:label id="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33_documentation_en-US" xlink:label="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Comprehensive income available to common shareholders</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33" xlink:to="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F9AD8E390AF788BE7E3100EA69975C33" xlink:type="arc" />
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_AE641CBBFEE89BE8B37900EA6997F8E4_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_AE641CBBFEE89BE8B37900EA6997F8E4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted average number of common shares outstanding - basic</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_AE641CBBFEE89BE8B37900EA6997F8E4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_AE641CBBFEE89BE8B37900EA6997F8E4" xlink:to="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_AE641CBBFEE89BE8B37900EA6997F8E4" xlink:type="arc" />
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_A0008CAED99954C4126900EA6997B2A3_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_A0008CAED99954C4126900EA6997B2A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted average number of common shares outstanding - diluted</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_A0008CAED99954C4126900EA6997B2A3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_A0008CAED99954C4126900EA6997B2A3" xlink:to="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_A0008CAED99954C4126900EA6997B2A3" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerShareBasic_485E55BB91E9518D9EDD00EA6997C747_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_485E55BB91E9518D9EDD00EA6997C747" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Net income per common share - basic</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_485E55BB91E9518D9EDD00EA6997C747" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasic_485E55BB91E9518D9EDD00EA6997C747" xlink:to="lab_us-gaap_EarningsPerShareBasic_485E55BB91E9518D9EDD00EA6997C747" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_CFC3F6555E107711FE6900EA69987A2B_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted_CFC3F6555E107711FE6900EA69987A2B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net income per common share - diluted</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_CFC3F6555E107711FE6900EA69987A2B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareDiluted_CFC3F6555E107711FE6900EA69987A2B" xlink:to="lab_us-gaap_EarningsPerShareDiluted_CFC3F6555E107711FE6900EA69987A2B" xlink:type="arc" />
    <link:label id="lab_agnc_DocumentAndEntityInformationAbstract_4CD3B34AA14CFBDF16F72C21C16FC56A_label_en-US" xlink:label="lab_agnc_DocumentAndEntityInformationAbstract_E02E8F9A51DE5AFC8B87431ED28267A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document and Entity Information [Abstract]</link:label>
    <link:label id="lab_agnc_DocumentAndEntityInformationAbstract_4CD3B34AA14CFBDF16F72C21C16FC56A_documentation_en-US" xlink:label="lab_agnc_DocumentAndEntityInformationAbstract_E02E8F9A51DE5AFC8B87431ED28267A0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">-- None. No documentation exists for this element. --</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DocumentAndEntityInformationAbstract" xlink:label="loc_agnc_DocumentAndEntityInformationAbstract_E02E8F9A51DE5AFC8B87431ED28267A0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DocumentAndEntityInformationAbstract_E02E8F9A51DE5AFC8B87431ED28267A0" xlink:to="lab_agnc_DocumentAndEntityInformationAbstract_E02E8F9A51DE5AFC8B87431ED28267A0" xlink:type="arc" />
    <link:label id="lab_dei_DocumentType_3F20CE55B5D76E60E4992C21C16FF7E9_terseLabel_en-US" xlink:label="lab_dei_DocumentType_83EE5FAF579E516A93445804EA6FE392" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Document Type</link:label>
    <link:label id="lab_dei_DocumentType_3F20CE55B5D76E60E4992C21C16FF7E9_label_en-US" xlink:label="lab_dei_DocumentType_83EE5FAF579E516A93445804EA6FE392" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Type</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_83EE5FAF579E516A93445804EA6FE392" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentType_83EE5FAF579E516A93445804EA6FE392" xlink:to="lab_dei_DocumentType_83EE5FAF579E516A93445804EA6FE392" xlink:type="arc" />
    <link:label id="lab_dei_AmendmentFlag_65FECAD9A8DF973C018C2C21C170AB52_terseLabel_en-US" xlink:label="lab_dei_AmendmentFlag_8981F7C9C0995C10AA55BCE822E199BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amendment Flag</link:label>
    <link:label id="lab_dei_AmendmentFlag_65FECAD9A8DF973C018C2C21C170AB52_label_en-US" xlink:label="lab_dei_AmendmentFlag_8981F7C9C0995C10AA55BCE822E199BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amendment Flag</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_8981F7C9C0995C10AA55BCE822E199BA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AmendmentFlag_8981F7C9C0995C10AA55BCE822E199BA" xlink:to="lab_dei_AmendmentFlag_8981F7C9C0995C10AA55BCE822E199BA" xlink:type="arc" />
    <link:label id="lab_dei_DocumentFiscalYearFocus_5E24B5C2E2E22168B49C2C21C170BC72_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus_71DE2D1C35DA5D47B6AE6204F4F89B15" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Document Fiscal Year Focus</link:label>
    <link:label id="lab_dei_DocumentFiscalYearFocus_5E24B5C2E2E22168B49C2C21C170BC72_label_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus_71DE2D1C35DA5D47B6AE6204F4F89B15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Fiscal Year Focus</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_71DE2D1C35DA5D47B6AE6204F4F89B15" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalYearFocus_71DE2D1C35DA5D47B6AE6204F4F89B15" xlink:to="lab_dei_DocumentFiscalYearFocus_71DE2D1C35DA5D47B6AE6204F4F89B15" xlink:type="arc" />
    <link:label id="lab_dei_DocumentFiscalPeriodFocus_A302BBD121EB48E3F5222C21C170811F_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus_C7E57805B5655D3089E48D5E99DB9756" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Document Fiscal Period Focus</link:label>
    <link:label id="lab_dei_DocumentFiscalPeriodFocus_A302BBD121EB48E3F5222C21C170811F_label_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus_C7E57805B5655D3089E48D5E99DB9756" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Fiscal Period Focus</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_C7E57805B5655D3089E48D5E99DB9756" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalPeriodFocus_C7E57805B5655D3089E48D5E99DB9756" xlink:to="lab_dei_DocumentFiscalPeriodFocus_C7E57805B5655D3089E48D5E99DB9756" xlink:type="arc" />
    <link:label id="lab_dei_EntityRegistrantName_425005050582F49484DC2C21C17036CA_terseLabel_en-US" xlink:label="lab_dei_EntityRegistrantName_289A25F076E15A93992CA511661A0B9B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:label id="lab_dei_EntityRegistrantName_425005050582F49484DC2C21C17036CA_label_en-US" xlink:label="lab_dei_EntityRegistrantName_289A25F076E15A93992CA511661A0B9B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_289A25F076E15A93992CA511661A0B9B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityRegistrantName_289A25F076E15A93992CA511661A0B9B" xlink:to="lab_dei_EntityRegistrantName_289A25F076E15A93992CA511661A0B9B" xlink:type="arc" />
    <link:label id="lab_dei_EntityCentralIndexKey_0260B75A22E8C98FDC4C2C21C170F288_terseLabel_en-US" xlink:label="lab_dei_EntityCentralIndexKey_70A6012A575858449435E65CC6177725" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:label id="lab_dei_EntityCentralIndexKey_0260B75A22E8C98FDC4C2C21C170F288_label_en-US" xlink:label="lab_dei_EntityCentralIndexKey_70A6012A575858449435E65CC6177725" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_70A6012A575858449435E65CC6177725" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCentralIndexKey_70A6012A575858449435E65CC6177725" xlink:to="lab_dei_EntityCentralIndexKey_70A6012A575858449435E65CC6177725" xlink:type="arc" />
    <link:label id="lab_dei_EntityFilerCategory_CE7CCD50A1F6468966052C21C1701303_terseLabel_en-US" xlink:label="lab_dei_EntityFilerCategory_070C0EB2944C5469A4D425D11851C032" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Filer Category</link:label>
    <link:label id="lab_dei_EntityFilerCategory_CE7CCD50A1F6468966052C21C1701303_label_en-US" xlink:label="lab_dei_EntityFilerCategory_070C0EB2944C5469A4D425D11851C032" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Filer Category</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_070C0EB2944C5469A4D425D11851C032" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityFilerCategory_070C0EB2944C5469A4D425D11851C032" xlink:to="lab_dei_EntityFilerCategory_070C0EB2944C5469A4D425D11851C032" xlink:type="arc" />
    <link:label id="lab_dei_CurrentFiscalYearEndDate_0668A771E811BC4EAED42C21C17016EE_terseLabel_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate_94C6C17BDC5C55159CF737ED443D2538" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Current Fiscal Year End Date</link:label>
    <link:label id="lab_dei_CurrentFiscalYearEndDate_0668A771E811BC4EAED42C21C17016EE_label_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate_94C6C17BDC5C55159CF737ED443D2538" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Current Fiscal Year End Date</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_94C6C17BDC5C55159CF737ED443D2538" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CurrentFiscalYearEndDate_94C6C17BDC5C55159CF737ED443D2538" xlink:to="lab_dei_CurrentFiscalYearEndDate_94C6C17BDC5C55159CF737ED443D2538" xlink:type="arc" />
    <link:label id="lab_dei_EntityCommonStockSharesOutstanding_29A0A472D32A3465B9692C21C170CB72_terseLabel_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_A6C82AFAEEBF56DCBE6AD81FC3EF86D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Common Stock, Shares Outstanding</link:label>
    <link:label id="lab_dei_EntityCommonStockSharesOutstanding_29A0A472D32A3465B9692C21C170CB72_label_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_A6C82AFAEEBF56DCBE6AD81FC3EF86D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Common Stock, Shares Outstanding</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_A6C82AFAEEBF56DCBE6AD81FC3EF86D9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCommonStockSharesOutstanding_A6C82AFAEEBF56DCBE6AD81FC3EF86D9" xlink:to="lab_dei_EntityCommonStockSharesOutstanding_A6C82AFAEEBF56DCBE6AD81FC3EF86D9" xlink:type="arc" />
    <link:label id="lab_dei_TradingSymbol_65B596969A43C3E185212C21C1702620_terseLabel_en-US" xlink:label="lab_dei_TradingSymbol_E1548345C1A651C4B02C1CB11BEE77C8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Trading Symbol</link:label>
    <link:label id="lab_dei_TradingSymbol_65B596969A43C3E185212C21C1702620_label_en-US" xlink:label="lab_dei_TradingSymbol_E1548345C1A651C4B02C1CB11BEE77C8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Trading Symbol</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_TradingSymbol" xlink:label="loc_dei_TradingSymbol_E1548345C1A651C4B02C1CB11BEE77C8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_TradingSymbol_E1548345C1A651C4B02C1CB11BEE77C8" xlink:to="lab_dei_TradingSymbol_E1548345C1A651C4B02C1CB11BEE77C8" xlink:type="arc" />
    <link:label id="lab_dei_EntityWellKnownSeasonedIssuer_8B795FBA80AEDEA83BAF2C21C17051AD_terseLabel_en-US" xlink:label="lab_dei_EntityWellKnownSeasonedIssuer_3B9FB6C132185167B3F36004EE90664A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Well-known Seasoned Issuer</link:label>
    <link:label id="lab_dei_EntityWellKnownSeasonedIssuer_8B795FBA80AEDEA83BAF2C21C17051AD_label_en-US" xlink:label="lab_dei_EntityWellKnownSeasonedIssuer_3B9FB6C132185167B3F36004EE90664A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Well-known Seasoned Issuer</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_3B9FB6C132185167B3F36004EE90664A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityWellKnownSeasonedIssuer_3B9FB6C132185167B3F36004EE90664A" xlink:to="lab_dei_EntityWellKnownSeasonedIssuer_3B9FB6C132185167B3F36004EE90664A" xlink:type="arc" />
    <link:label id="lab_dei_EntityVoluntaryFilers_9C523B8919F2B1707BE92C21C17025CE_terseLabel_en-US" xlink:label="lab_dei_EntityVoluntaryFilers_19C304FAFABB56A4A1974A8CDBB9A517" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Voluntary Filers</link:label>
    <link:label id="lab_dei_EntityVoluntaryFilers_9C523B8919F2B1707BE92C21C17025CE_label_en-US" xlink:label="lab_dei_EntityVoluntaryFilers_19C304FAFABB56A4A1974A8CDBB9A517" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Voluntary Filers</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_19C304FAFABB56A4A1974A8CDBB9A517" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityVoluntaryFilers_19C304FAFABB56A4A1974A8CDBB9A517" xlink:to="lab_dei_EntityVoluntaryFilers_19C304FAFABB56A4A1974A8CDBB9A517" xlink:type="arc" />
    <link:label id="lab_dei_EntityCurrentReportingStatus_CCF227BC7392231385DC2C21C1705E47_terseLabel_en-US" xlink:label="lab_dei_EntityCurrentReportingStatus_7D10790065555C568B4A0710F5B08092" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Current Reporting Status</link:label>
    <link:label id="lab_dei_EntityCurrentReportingStatus_CCF227BC7392231385DC2C21C1705E47_label_en-US" xlink:label="lab_dei_EntityCurrentReportingStatus_7D10790065555C568B4A0710F5B08092" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Current Reporting Status</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_7D10790065555C568B4A0710F5B08092" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCurrentReportingStatus_7D10790065555C568B4A0710F5B08092" xlink:to="lab_dei_EntityCurrentReportingStatus_7D10790065555C568B4A0710F5B08092" xlink:type="arc" />
    <link:label id="lab_dei_EntityPublicFloat_0631E02468C02F2536922C21C1700E5C_terseLabel_en-US" xlink:label="lab_dei_EntityPublicFloat_2FAA2D3F5E8E55ABB2F816AEFBFB5934" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Public Float</link:label>
    <link:label id="lab_dei_EntityPublicFloat_0631E02468C02F2536922C21C1700E5C_label_en-US" xlink:label="lab_dei_EntityPublicFloat_2FAA2D3F5E8E55ABB2F816AEFBFB5934" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Public Float</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_2FAA2D3F5E8E55ABB2F816AEFBFB5934" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityPublicFloat_2FAA2D3F5E8E55ABB2F816AEFBFB5934" xlink:to="lab_dei_EntityPublicFloat_2FAA2D3F5E8E55ABB2F816AEFBFB5934" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E1324AFFD44FD52AE9F8B8E923616FF5_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_C6DB492153F05F2F96BEAA2542317300" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Available-for-sale Securities [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E1324AFFD44FD52AE9F8B8E923616FF5_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_C6DB492153F05F2F96BEAA2542317300" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Available-for-sale Securities [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_C6DB492153F05F2F96BEAA2542317300" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_C6DB492153F05F2F96BEAA2542317300" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_C6DB492153F05F2F96BEAA2542317300" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_FE597BA6586E12295C82B8E92362FD69_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis_07287F80C71D51EB9656A6A436699AAD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_FE597BA6586E12295C82B8E92362FD69_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis_07287F80C71D51EB9656A6A436699AAD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_07287F80C71D51EB9656A6A436699AAD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentAxis_07287F80C71D51EB9656A6A436699AAD" xlink:to="lab_us-gaap_FinancialInstrumentAxis_07287F80C71D51EB9656A6A436699AAD" xlink:type="arc" />
    <link:label id="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8E0868BFF3FA41A90A5FB8E923624551_verboseLabel_en-US" xlink:label="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3FA7A47F79F65292915BD7D14AB6E97F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Financial Instruments [Domain]</link:label>
    <link:label id="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8E0868BFF3FA41A90A5FB8E923624551_label_en-US" xlink:label="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3FA7A47F79F65292915BD7D14AB6E97F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instruments [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3FA7A47F79F65292915BD7D14AB6E97F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3FA7A47F79F65292915BD7D14AB6E97F" xlink:to="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3FA7A47F79F65292915BD7D14AB6E97F" xlink:type="arc" />
    <link:label id="lab_agnc_CreditRiskTransferSecuritiesMember_B1B4B91D26BA59ECCBA8B8E923624C2A_terseLabel_en-US" xlink:label="lab_agnc_CreditRiskTransferSecuritiesMember_1A10E6038E8F52C9BA37A05C636BFD8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Credit Risk Transfer Securities [Member]</link:label>
    <link:label id="lab_agnc_CreditRiskTransferSecuritiesMember_B1B4B91D26BA59ECCBA8B8E923624C2A_label_en-US" xlink:label="lab_agnc_CreditRiskTransferSecuritiesMember_1A10E6038E8F52C9BA37A05C636BFD8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit Risk Transfer Securities [Member]</link:label>
    <link:label id="lab_agnc_CreditRiskTransferSecuritiesMember_B1B4B91D26BA59ECCBA8B8E923624C2A_documentation_en-US" xlink:label="lab_agnc_CreditRiskTransferSecuritiesMember_1A10E6038E8F52C9BA37A05C636BFD8F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">GSE Credit Risk Transfer Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_1A10E6038E8F52C9BA37A05C636BFD8F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CreditRiskTransferSecuritiesMember_1A10E6038E8F52C9BA37A05C636BFD8F" xlink:to="lab_agnc_CreditRiskTransferSecuritiesMember_1A10E6038E8F52C9BA37A05C636BFD8F" xlink:type="arc" />
    <link:label id="lab_us-gaap_MinimumMember_EC1D1C7DA16E72918284B8E923622B24_terseLabel_en-US" xlink:label="lab_us-gaap_MinimumMember_0354F99BD63752E1B344F7A08048FBB7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Minimum [Member]</link:label>
    <link:label id="lab_us-gaap_MinimumMember_EC1D1C7DA16E72918284B8E923622B24_label_en-US" xlink:label="lab_us-gaap_MinimumMember_0354F99BD63752E1B344F7A08048FBB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Minimum [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_0354F99BD63752E1B344F7A08048FBB7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MinimumMember_0354F99BD63752E1B344F7A08048FBB7" xlink:to="lab_us-gaap_MinimumMember_0354F99BD63752E1B344F7A08048FBB7" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaximumMember_D184E9FCCE91E813B08CB8E92362D84E_terseLabel_en-US" xlink:label="lab_us-gaap_MaximumMember_39FBD4E5F2575AA4AE45524D8EE0952A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum [Member]</link:label>
    <link:label id="lab_us-gaap_MaximumMember_D184E9FCCE91E813B08CB8E92362D84E_label_en-US" xlink:label="lab_us-gaap_MaximumMember_39FBD4E5F2575AA4AE45524D8EE0952A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maximum [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_39FBD4E5F2575AA4AE45524D8EE0952A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaximumMember_39FBD4E5F2575AA4AE45524D8EE0952A" xlink:to="lab_us-gaap_MaximumMember_39FBD4E5F2575AA4AE45524D8EE0952A" xlink:type="arc" />
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_765E610B907B3E23BF65B8E92363645F_terseLabel_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_00C22BF64D065DBE9AA213E53E66F2DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Mortgage-backed Securities, Issued by Private Enterprises [Member]</link:label>
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_765E610B907B3E23BF65B8E92363645F_label_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_00C22BF64D065DBE9AA213E53E66F2DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Mortgage-backed Securities, Issued by Private Enterprises [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_00C22BF64D065DBE9AA213E53E66F2DB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_00C22BF64D065DBE9AA213E53E66F2DB" xlink:to="lab_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_00C22BF64D065DBE9AA213E53E66F2DB" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommercialMortgageBackedSecuritiesMember_E655CA138D24B02148AAB8E9236335A5_terseLabel_en-US" xlink:label="lab_us-gaap_CommercialMortgageBackedSecuritiesMember_E7A6E51762735A7C8A42C26447A30C81" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Commercial Mortgage Backed Securities [Member]</link:label>
    <link:label id="lab_us-gaap_CommercialMortgageBackedSecuritiesMember_E655CA138D24B02148AAB8E9236335A5_label_en-US" xlink:label="lab_us-gaap_CommercialMortgageBackedSecuritiesMember_E7A6E51762735A7C8A42C26447A30C81" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Commercial Mortgage Backed Securities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_E7A6E51762735A7C8A42C26447A30C81" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_E7A6E51762735A7C8A42C26447A30C81" xlink:to="lab_us-gaap_CommercialMortgageBackedSecuritiesMember_E7A6E51762735A7C8A42C26447A30C81" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CAFB73E1004386AA17F3B8E9236393AC_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_686E4CB04EC45182A292A0F9F09F9B40" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Available-for-sale Securities [Line Items]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CAFB73E1004386AA17F3B8E9236393AC_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_686E4CB04EC45182A292A0F9F09F9B40" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Available-for-sale Securities [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_686E4CB04EC45182A292A0F9F09F9B40" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_686E4CB04EC45182A292A0F9F09F9B40" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_686E4CB04EC45182A292A0F9F09F9B40" xlink:type="arc" />
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_B8E24E53B09C7D553388B8E923633B1D_terseLabel_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_37E966AAA4175393AD30301ADCE003E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Mortgage-backed Securities Available-for-sale, Fair Value Disclosure</link:label>
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_B8E24E53B09C7D553388B8E923633B1D_label_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_37E966AAA4175393AD30301ADCE003E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Mortgage-backed Securities Available-for-sale, Fair Value Disclosure</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:label="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_37E966AAA4175393AD30301ADCE003E2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_37E966AAA4175393AD30301ADCE003E2" xlink:to="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_37E966AAA4175393AD30301ADCE003E2" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_EAF44D9AAE4C1F5E2499B8E923636203_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_1A3117B596A65BEC87932FA24BCCC5D1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Net long TBA position, at fair value</link:label>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_EAF44D9AAE4C1F5E2499B8E923636203_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_1A3117B596A65BEC87932FA24BCCC5D1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Asset, Fair Value, Gross Asset</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1A3117B596A65BEC87932FA24BCCC5D1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1A3117B596A65BEC87932FA24BCCC5D1" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_1A3117B596A65BEC87932FA24BCCC5D1" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeNet_977CB4E41AE1990097F9B8E923637930_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeNet_731B23340A485EC09895E30653D9A72D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">TBA, net carrying value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_731B23340A485EC09895E30653D9A72D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeNet_731B23340A485EC09895E30653D9A72D" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeNet_731B23340A485EC09895E30653D9A72D" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_7B058534DAB2047033FEB8E92363515B_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_0BE34EBF2524566088685C64FE4ABB31" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unamortized premium balance</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_7B058534DAB2047033FEB8E92363515B_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_0BE34EBF2524566088685C64FE4ABB31" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Unamortized Discount (Premium), Net</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_0BE34EBF2524566088685C64FE4ABB31" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_0BE34EBF2524566088685C64FE4ABB31" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_0BE34EBF2524566088685C64FE4ABB31" xlink:type="arc" />
    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_B029899F44D8412E6010B8E923630BAD_verboseLabel_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_10A8E29BC1295CC88B7C2B1FF81E810D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted average expected constant prepayment rate</link:label>
    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_B029899F44D8412E6010B8E923630BAD_label_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_10A8E29BC1295CC88B7C2B1FF81E810D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Future Prepayment Rate Assumption Of Investment Portfolio</link:label>
    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_B029899F44D8412E6010B8E923630BAD_documentation_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_10A8E29BC1295CC88B7C2B1FF81E810D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Average future constant repayment rate assumption of Investment Portfolio.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_10A8E29BC1295CC88B7C2B1FF81E810D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_10A8E29BC1295CC88B7C2B1FF81E810D" xlink:to="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_10A8E29BC1295CC88B7C2B1FF81E810D" xlink:type="arc" />
    <link:label id="lab_agnc_WeightedAverageCouponRate_8CBB5433B37CE670508EB8E923631AF5_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageCouponRate_61383BA1BA955C77AA5C85C243B6FDC5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Coupon Rate</link:label>
    <link:label id="lab_agnc_WeightedAverageCouponRate_8CBB5433B37CE670508EB8E923631AF5_label_en-US" xlink:label="lab_agnc_WeightedAverageCouponRate_61383BA1BA955C77AA5C85C243B6FDC5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted Average Coupon Rate</link:label>
    <link:label id="lab_agnc_WeightedAverageCouponRate_8CBB5433B37CE670508EB8E923631AF5_documentation_en-US" xlink:label="lab_agnc_WeightedAverageCouponRate_61383BA1BA955C77AA5C85C243B6FDC5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Weighted Average Coupon Rate</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_WeightedAverageCouponRate" xlink:label="loc_agnc_WeightedAverageCouponRate_61383BA1BA955C77AA5C85C243B6FDC5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_WeightedAverageCouponRate_61383BA1BA955C77AA5C85C243B6FDC5" xlink:to="lab_agnc_WeightedAverageCouponRate_61383BA1BA955C77AA5C85C243B6FDC5" xlink:type="arc" />
    <link:label id="lab_agnc_UnderlyingCollateralCoupon_DCFC44B6BDEF88A0B6CEB8E92364AC63_terseLabel_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon_1B125D754CC5583B8F1597EE436204DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Underlying Collateral Coupon</link:label>
    <link:label id="lab_agnc_UnderlyingCollateralCoupon_DCFC44B6BDEF88A0B6CEB8E92364AC63_label_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon_1B125D754CC5583B8F1597EE436204DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Underlying Collateral Coupon</link:label>
    <link:label id="lab_agnc_UnderlyingCollateralCoupon_DCFC44B6BDEF88A0B6CEB8E92364AC63_documentation_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon_1B125D754CC5583B8F1597EE436204DC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Underlying Collateral Coupon</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_UnderlyingCollateralCoupon" xlink:label="loc_agnc_UnderlyingCollateralCoupon_1B125D754CC5583B8F1597EE436204DC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_UnderlyingCollateralCoupon_1B125D754CC5583B8F1597EE436204DC" xlink:to="lab_agnc_UnderlyingCollateralCoupon_1B125D754CC5583B8F1597EE436204DC" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_2D6441CC325C6DA9BA02B8E9236416F3_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B246D705AE0B58EE828F82EB37B92193" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Debt Securities</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_2D6441CC325C6DA9BA02B8E9236416F3_label_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B246D705AE0B58EE828F82EB37B92193" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Debt Securities</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_2D6441CC325C6DA9BA02B8E9236416F3_documentation_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B246D705AE0B58EE828F82EB37B92193" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of debt securities remeasured at fair value through earnings.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B246D705AE0B58EE828F82EB37B92193" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B246D705AE0B58EE828F82EB37B92193" xlink:to="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B246D705AE0B58EE828F82EB37B92193" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecuritiesHeldAsCollateralAtFairValue_BAAA328124E37E14F0CAB8E92364B320_verboseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesHeldAsCollateralAtFairValue_3A774CDC0A4358FF86AEF9EFE284C459" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities, total fair value</link:label>
    <link:label id="lab_us-gaap_SecuritiesHeldAsCollateralAtFairValue_BAAA328124E37E14F0CAB8E92364B320_label_en-US" xlink:label="lab_us-gaap_SecuritiesHeldAsCollateralAtFairValue_3A774CDC0A4358FF86AEF9EFE284C459" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Held as Collateral, at Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuritiesHeldAsCollateralAtFairValue" xlink:label="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_3A774CDC0A4358FF86AEF9EFE284C459" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_3A774CDC0A4358FF86AEF9EFE284C459" xlink:to="lab_us-gaap_SecuritiesHeldAsCollateralAtFairValue_3A774CDC0A4358FF86AEF9EFE284C459" xlink:type="arc" />
    <link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_40736156E7F2D913E338B8E92364F948_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_9FABFCB31FE2537FB2ABF4DAAAB9F555" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Variable Interest Entity, Consolidated, Carrying Amount, Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_9FABFCB31FE2537FB2ABF4DAAAB9F555" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_9FABFCB31FE2537FB2ABF4DAAAB9F555" xlink:to="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_9FABFCB31FE2537FB2ABF4DAAAB9F555" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherLongTermDebt_D9E28EA4B8837BFA6607B8E9236473DE_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt_1DD231E6A4245C0EB620C71BC7DC11C5" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Debt, at fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_1DD231E6A4245C0EB620C71BC7DC11C5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLongTermDebt_1DD231E6A4245C0EB620C71BC7DC11C5" xlink:to="lab_us-gaap_OtherLongTermDebt_1DD231E6A4245C0EB620C71BC7DC11C5" xlink:type="arc" />
    <link:label id="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_B147DBAE36423091C262B8E92364467E_verboseLabel_en-US" xlink:label="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_3D36618F64EE5333ACC35AA235250B7B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fair value of CMO securities and interest-only and principal-only strips</link:label>
    <link:label id="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_B147DBAE36423091C262B8E92364467E_label_en-US" xlink:label="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_3D36618F64EE5333ACC35AA235250B7B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Of CMO Securities Directly Held</link:label>
    <link:label id="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_B147DBAE36423091C262B8E92364467E_documentation_en-US" xlink:label="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_3D36618F64EE5333ACC35AA235250B7B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The sum of the fair values, as of the date of each statement of financial position presented, of directly held CMO securities and interest-only securities including retained interest in transfers treated as sales but excluding securities held by consolidated CMO trust.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_FairValueOfCmoSecuritiesDirectlyHeld" xlink:label="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_3D36618F64EE5333ACC35AA235250B7B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_3D36618F64EE5333ACC35AA235250B7B" xlink:to="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_3D36618F64EE5333ACC35AA235250B7B" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritizedCmoSecurities_4D8FA0FC66BA59A7551FB8E923649F59_verboseLabel_en-US" xlink:label="lab_agnc_SecuritizedCmoSecurities_C6013B030073560F8547E85C8BF68153" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Securitized CMO Securities</link:label>
    <link:label id="lab_agnc_SecuritizedCmoSecurities_4D8FA0FC66BA59A7551FB8E923649F59_label_en-US" xlink:label="lab_agnc_SecuritizedCmoSecurities_C6013B030073560F8547E85C8BF68153" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securitized CMO Securities</link:label>
    <link:label id="lab_agnc_SecuritizedCmoSecurities_4D8FA0FC66BA59A7551FB8E923649F59_documentation_en-US" xlink:label="lab_agnc_SecuritizedCmoSecurities_C6013B030073560F8547E85C8BF68153" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The sum of the fair values, as of the date of each statement of financial position presented, of directly held CMO securities and interest-only securities including retained interest in transfers treated as sales and the fair value of securities held by consolidated CMO trusts.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritizedCmoSecurities" xlink:label="loc_agnc_SecuritizedCmoSecurities_C6013B030073560F8547E85C8BF68153" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritizedCmoSecurities_C6013B030073560F8547E85C8BF68153" xlink:to="lab_agnc_SecuritizedCmoSecurities_C6013B030073560F8547E85C8BF68153" xlink:type="arc" />
    <link:label id="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_B86B787A2EE4DD0CEA2FB8E923643FFC_terseLabel_en-US" xlink:label="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_FAB56353B877554F83BCAE8C1E7B0245" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">CMO and Interest Only, Principal Only Securities, Maximum Loss Exposure</link:label>
    <link:label id="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_B86B787A2EE4DD0CEA2FB8E923643FFC_label_en-US" xlink:label="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_FAB56353B877554F83BCAE8C1E7B0245" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">CMO and Interest Only, Pricincipal Only Securities, Maximum Loss Exposure</link:label>
    <link:label id="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_B86B787A2EE4DD0CEA2FB8E923643FFC_documentation_en-US" xlink:label="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_FAB56353B877554F83BCAE8C1E7B0245" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">CMO and Interest Only and Pricincipal Only Securities, Maximum Loss Exposure</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" xlink:label="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_FAB56353B877554F83BCAE8C1E7B0245" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_FAB56353B877554F83BCAE8C1E7B0245" xlink:to="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_FAB56353B877554F83BCAE8C1E7B0245" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_D62AC073544EC76294BEB8E923640D5A_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_F9AC179E357A59AA91BD9294AD7A769E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total available-for-sale securities, at fair value</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_D62AC073544EC76294BEB8E923640D5A_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_F9AC179E357A59AA91BD9294AD7A769E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Debt Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_F9AC179E357A59AA91BD9294AD7A769E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_F9AC179E357A59AA91BD9294AD7A769E" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_F9AC179E357A59AA91BD9294AD7A769E" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252_terseLabel_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252_label_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252_documentation_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativeByMaturityYearsAxis" xlink:label="loc_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252" xlink:to="lab_agnc_DerivativeByMaturityYearsAxis_3B4B970825F842E6F6F600D928796252" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF_terseLabel_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF_label_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF_documentation_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Derivative By Maturity Years [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativeByMaturityYearsDomain" xlink:label="loc_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF" xlink:to="lab_agnc_DerivativeByMaturityYearsDomain_2D03DF23198FF4093B9000D9287916FF" xlink:type="arc" />
    <link:label id="lab_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F_terseLabel_en-US" xlink:label="lab_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">30 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F_label_en-US" xlink:label="lab_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">30 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F_documentation_en-US" xlink:label="lab_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">30 Year Maturity [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A30YearMaturityMember" xlink:label="loc_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F" xlink:to="lab_agnc_A30YearMaturityMember_535C57433C5FFF307D4700D928795A6F" xlink:type="arc" />
    <link:label id="lab_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7_terseLabel_en-US" xlink:label="lab_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">15 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7_label_en-US" xlink:label="lab_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">15 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7_documentation_en-US" xlink:label="lab_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">15 Year Maturity [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A15YearMaturityMember" xlink:label="loc_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7" xlink:to="lab_agnc_A15YearMaturityMember_C20FB448736E1180E43C00D9287A47F7" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4_terseLabel_en-US" xlink:label="lab_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivatives by Issuer [Axis]</link:label>
    <link:label id="lab_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4_label_en-US" xlink:label="lab_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivatives by Issuer [Axis]</link:label>
    <link:label id="lab_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4_documentation_en-US" xlink:label="lab_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivatives by Issuer [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativesbyIssuerAxis" xlink:label="loc_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4" xlink:to="lab_agnc_DerivativesbyIssuerAxis_5EAAFDD206BB8E12171200D9287A26D4" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E_terseLabel_en-US" xlink:label="lab_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivatives by Issuer [Domain]</link:label>
    <link:label id="lab_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E_label_en-US" xlink:label="lab_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivatives by Issuer [Domain]</link:label>
    <link:label id="lab_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E_documentation_en-US" xlink:label="lab_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Derivatives by Issuer [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativesbyIssuerDomain" xlink:label="loc_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E" xlink:to="lab_agnc_DerivativesbyIssuerDomain_0434BEF0380DF87D4A2B00D9287A700E" xlink:type="arc" />
    <link:label id="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_AC6A5BA75DF170891FC200D9287A0D30_verboseLabel_en-US" xlink:label="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_AC6A5BA75DF170891FC200D9287A0D30" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Government National Mortgage Association Certificates and Obligations (GNMA) [Member]</link:label>
    <link:label id="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_AC6A5BA75DF170891FC200D9287A0D30_label_en-US" xlink:label="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_AC6A5BA75DF170891FC200D9287A0D30" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Government National Mortgage Association Certificates and Obligations (GNMA) [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_AC6A5BA75DF170891FC200D9287A0D30" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_AC6A5BA75DF170891FC200D9287A0D30" xlink:to="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_AC6A5BA75DF170891FC200D9287A0D30" xlink:type="arc" />
    <link:label id="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E97C28D1E3B5FE7C466300D9287BD5B2_verboseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E97C28D1E3B5FE7C466300D9287BD5B2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Federal Home Loan Mortgage Corporation Certificates and Obligations (FHLMC) [Member]</link:label>
    <link:label id="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E97C28D1E3B5FE7C466300D9287BD5B2_label_en-US" xlink:label="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E97C28D1E3B5FE7C466300D9287BD5B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Mortgage Corporation Certificates and Obligations (FHLMC) [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E97C28D1E3B5FE7C466300D9287BD5B2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E97C28D1E3B5FE7C466300D9287BD5B2" xlink:to="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E97C28D1E3B5FE7C466300D9287BD5B2" xlink:type="arc" />
    <link:label id="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_AD8A74C27C436290415300D9287B5FAE_verboseLabel_en-US" xlink:label="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_AD8A74C27C436290415300D9287B5FAE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Federal National Mortgage Association Certificates and Obligations (FNMA) [Member]</link:label>
    <link:label id="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_AD8A74C27C436290415300D9287B5FAE_label_en-US" xlink:label="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_AD8A74C27C436290415300D9287B5FAE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal National Mortgage Association Certificates and Obligations (FNMA) [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_AD8A74C27C436290415300D9287B5FAE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_AD8A74C27C436290415300D9287B5FAE" xlink:to="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_AD8A74C27C436290415300D9287B5FAE" xlink:type="arc" />
    <link:label id="lab_us-gaap_PositionAxis_E4E72350330CED5ED78500D9287B3FCE_terseLabel_en-US" xlink:label="lab_us-gaap_PositionAxis_E4E72350330CED5ED78500D9287B3FCE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Position [Axis]</link:label>
    <link:label id="lab_us-gaap_PositionAxis_E4E72350330CED5ED78500D9287B3FCE_label_en-US" xlink:label="lab_us-gaap_PositionAxis_E4E72350330CED5ED78500D9287B3FCE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Position [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_E4E72350330CED5ED78500D9287B3FCE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PositionAxis_E4E72350330CED5ED78500D9287B3FCE" xlink:to="lab_us-gaap_PositionAxis_E4E72350330CED5ED78500D9287B3FCE" xlink:type="arc" />
    <link:label id="lab_us-gaap_PositionDomain_676FA8D2A11325094B0F00D9287BBAC2_terseLabel_en-US" xlink:label="lab_us-gaap_PositionDomain_676FA8D2A11325094B0F00D9287BBAC2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Position [Domain]</link:label>
    <link:label id="lab_us-gaap_PositionDomain_676FA8D2A11325094B0F00D9287BBAC2_label_en-US" xlink:label="lab_us-gaap_PositionDomain_676FA8D2A11325094B0F00D9287BBAC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Position [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_676FA8D2A11325094B0F00D9287BBAC2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PositionDomain_676FA8D2A11325094B0F00D9287BBAC2" xlink:to="lab_us-gaap_PositionDomain_676FA8D2A11325094B0F00D9287BBAC2" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortMember_A3930D9226257A56C9F900D9287BBEC7_terseLabel_en-US" xlink:label="lab_us-gaap_ShortMember_A3930D9226257A56C9F900D9287BBEC7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short [Member]</link:label>
    <link:label id="lab_us-gaap_ShortMember_A3930D9226257A56C9F900D9287BBEC7_label_en-US" xlink:label="lab_us-gaap_ShortMember_A3930D9226257A56C9F900D9287BBEC7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_A3930D9226257A56C9F900D9287BBEC7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortMember_A3930D9226257A56C9F900D9287BBEC7" xlink:to="lab_us-gaap_ShortMember_A3930D9226257A56C9F900D9287BBEC7" xlink:type="arc" />
    <link:label id="lab_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B_terseLabel_en-US" xlink:label="lab_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B_label_en-US" xlink:label="lab_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">2.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B_documentation_en-US" xlink:label="lab_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">2.5% Coupon [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A2.5CouponMember" xlink:label="loc_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B" xlink:to="lab_agnc_A2.5CouponMember_1D2C5519F3A45CCC402C00D9287CA90B" xlink:type="arc" />
    <link:label id="lab_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4_terseLabel_en-US" xlink:label="lab_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3.0% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4_label_en-US" xlink:label="lab_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">3.0% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4_documentation_en-US" xlink:label="lab_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">3.0% Coupon [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A3.0CouponMember" xlink:label="loc_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4" xlink:to="lab_agnc_A3.0CouponMember_4074185BEDA681968D3000D9287DD9F4" xlink:type="arc" />
    <link:label id="lab_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429_terseLabel_en-US" xlink:label="lab_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429_label_en-US" xlink:label="lab_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">3.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429_documentation_en-US" xlink:label="lab_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">3.5% Coupon [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A3.5CouponMember" xlink:label="loc_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429" xlink:to="lab_agnc_A3.5CouponMember_6FBD6E993831338D94F900D9287DA429" xlink:type="arc" />
    <link:label id="lab_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF_terseLabel_en-US" xlink:label="lab_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">4.0% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF_label_en-US" xlink:label="lab_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">4.0% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF_documentation_en-US" xlink:label="lab_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">4.0% Coupon [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A4.0CouponMember" xlink:label="loc_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF" xlink:to="lab_agnc_A4.0CouponMember_741209E4BF4A75CB4CFB00D9287D68DF" xlink:type="arc" />
    <link:label id="lab_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2_terseLabel_en-US" xlink:label="lab_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">4.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2_label_en-US" xlink:label="lab_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">4.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2_documentation_en-US" xlink:label="lab_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">4.5% Coupon [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A4.5CouponMember" xlink:label="loc_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2" xlink:to="lab_agnc_A4.5CouponMember_940E6C03373EB0C07AA800D9287D4AB2" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeForwardSettlementValue_7C5AFAF19517449B4D0400D92886D618_negatedLabel_en-US" xlink:label="lab_agnc_DerivativeForwardSettlementValue_7C5AFAF19517449B4D0400D92886D618" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Cost Basis</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_7C5AFAF19517449B4D0400D92886D618" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeForwardSettlementValue_7C5AFAF19517449B4D0400D92886D618" xlink:to="lab_agnc_DerivativeForwardSettlementValue_7C5AFAF19517449B4D0400D92886D618" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_B282027583A4681576F700D928865FAA_negatedLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_B282027583A4681576F700D928865FAA" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Net long TBA position, at fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_B282027583A4681576F700D928865FAA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_B282027583A4681576F700D928865FAA" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_B282027583A4681576F700D928865FAA" xlink:type="arc" />
    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_8CB2F3B5A954BFB07A3AADEB6803F7A6_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_B9EB05F75B9057E8913E4A4BCBD3543D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Organization, Consolidation and Presentation of Financial Statements [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_B9EB05F75B9057E8913E4A4BCBD3543D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_B9EB05F75B9057E8913E4A4BCBD3543D" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_B9EB05F75B9057E8913E4A4BCBD3543D" xlink:type="arc" />
    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_D4E1B8143E1F10CAA9CEADEB68032CFF_verboseLabel_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_D6F0F6D01C065DAD841D00243C81131A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Organization</link:label>
    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_D4E1B8143E1F10CAA9CEADEB68032CFF_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_D6F0F6D01C065DAD841D00243C81131A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_D6F0F6D01C065DAD841D00243C81131A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_D6F0F6D01C065DAD841D00243C81131A" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_D6F0F6D01C065DAD841D00243C81131A" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_FADB94089855CFA0DD04ADEB67000266_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_5D45EB076D9559B3A29BEB15B28A156C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_FADB94089855CFA0DD04ADEB67000266_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_5D45EB076D9559B3A29BEB15B28A156C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_5D45EB076D9559B3A29BEB15B28A156C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_5D45EB076D9559B3A29BEB15B28A156C" xlink:to="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_5D45EB076D9559B3A29BEB15B28A156C" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerShareTextBlock_9930BDBCEAB0D41ECF87ADEB67005CCB_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_3F5D795D30715450B6DFA97ADEBE0BD1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Earnings Per Share [Text Block]</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareTextBlock_9930BDBCEAB0D41ECF87ADEB67005CCB_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_3F5D795D30715450B6DFA97ADEBE0BD1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings Per Share [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_3F5D795D30715450B6DFA97ADEBE0BD1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareTextBlock_3F5D795D30715450B6DFA97ADEBE0BD1" xlink:to="lab_us-gaap_EarningsPerShareTextBlock_3F5D795D30715450B6DFA97ADEBE0BD1" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_5274F7B622898FB8863400ACB6C0A6F1_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_5274F7B622898FB8863400ACB6C0A6F1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Less than 30 Days [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_5274F7B622898FB8863400ACB6C0A6F1_label_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_5274F7B622898FB8863400ACB6C0A6F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Less than 30 Days [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_5274F7B622898FB8863400ACB6C0A6F1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_5274F7B622898FB8863400ACB6C0A6F1" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_5274F7B622898FB8863400ACB6C0A6F1" xlink:type="arc" />
    <link:label id="lab_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12_terseLabel_en-US" xlink:label="lab_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity 31 To 59 Days [Member]</link:label>
    <link:label id="lab_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12_label_en-US" xlink:label="lab_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity 31 To 59 Days [Member]</link:label>
    <link:label id="lab_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12_documentation_en-US" xlink:label="lab_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Maturity 31 To 59 Days [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Maturity31To59DaysMember" xlink:label="loc_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12" xlink:to="lab_agnc_Maturity31To59DaysMember_B21177A2D42DD2AE948400ACB6C13A12" xlink:type="arc" />
    <link:label id="lab_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2_terseLabel_en-US" xlink:label="lab_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity 60 To 90 Days [Member]</link:label>
    <link:label id="lab_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2_label_en-US" xlink:label="lab_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity 60 To 90 Days [Member]</link:label>
    <link:label id="lab_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2_documentation_en-US" xlink:label="lab_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Maturity 60 To 90 Days [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Maturity60To90DaysMember" xlink:label="loc_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2" xlink:to="lab_agnc_Maturity60To90DaysMember_3E39DB6282BE76F75EA900ACB6C198F2" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityOver90DaysMember_A940D9CB12C0B0F7576B00ACB6C152BF_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOver90DaysMember_A940D9CB12C0B0F7576B00ACB6C152BF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity over 90 days [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityOver90DaysMember_A940D9CB12C0B0F7576B00ACB6C152BF_label_en-US" xlink:label="lab_us-gaap_MaturityOver90DaysMember_A940D9CB12C0B0F7576B00ACB6C152BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Greater than 90 Days [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaturityOver90DaysMember" xlink:label="loc_us-gaap_MaturityOver90DaysMember_A940D9CB12C0B0F7576B00ACB6C152BF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityOver90DaysMember_A940D9CB12C0B0F7576B00ACB6C152BF" xlink:to="lab_us-gaap_MaturityOver90DaysMember_A940D9CB12C0B0F7576B00ACB6C152BF" xlink:type="arc" />
    <link:label id="lab_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B_terseLabel_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B_label_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B_documentation_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">U.S. Treasury Repurchase Agreements from 2 Days to 1 Month [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B" xlink:to="lab_agnc_A2Daysto1MonthMember_D57CAACE7D918BED9B4D00ACB6C1421B" xlink:type="arc" />
    <link:label id="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46_verboseLabel_en-US" xlink:label="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Retained Interests in Consolidated VIE's Pledged as Collateral Under Repo</link:label>
    <link:label id="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46_label_en-US" xlink:label="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Retained Interests in Consolidated VIE's Pledged as Collateral Under Repurchase Agreements</link:label>
    <link:label id="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46_documentation_en-US" xlink:label="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Retained Interests in Consolidated VIE's Pledged as Collateral Under Repurchase Agreements</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46" xlink:to="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_F3E5F66BF39C1F01DB9500ACB6C21C46" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_4A4EEF9C4123B9B6B40000ACB6C269DD_terseLabel_en-US" xlink:label="lab_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_4A4EEF9C4123B9B6B40000ACB6C269DD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Security Owned and Pledged as Collateral, Fair Value</link:label>
    <link:label id="lab_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_4A4EEF9C4123B9B6B40000ACB6C269DD_label_en-US" xlink:label="lab_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_4A4EEF9C4123B9B6B40000ACB6C269DD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Security Owned and Pledged as Collateral, Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_4A4EEF9C4123B9B6B40000ACB6C269DD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_4A4EEF9C4123B9B6B40000ACB6C269DD" xlink:to="lab_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_4A4EEF9C4123B9B6B40000ACB6C269DD" xlink:type="arc" />
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22_terseLabel_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Agency Securities Pledged As Collateral Amortized Cost</link:label>
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22_label_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Agency Securities Pledged As Collateral Amortized Cost</link:label>
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22_documentation_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Item represents agency securities pledged as collateral at amortized cost.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22" xlink:to="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_28F1C2F49D6FBF8DD0AD00ACB6C2AA22" xlink:type="arc" />
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975_terseLabel_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Agency Securities Pledged As Collateral Accrued Interest</link:label>
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975_label_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Agency Securities Pledged As Collateral Accrued Interest</link:label>
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975_documentation_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Item represents accrued interest on agency securities pledged as collateral.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975" xlink:to="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_B845FD2EF9E265A2BA6400ACB6C27975" xlink:type="arc" />
    <link:label id="lab_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_4BCCEEF76F17EF2DED3600ACB6C3A539_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_4BCCEEF76F17EF2DED3600ACB6C3A539" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities Received as Collateral, Amount Repledged and Sold</link:label>
    <link:label id="lab_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_4BCCEEF76F17EF2DED3600ACB6C3A539_label_en-US" xlink:label="lab_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_4BCCEEF76F17EF2DED3600ACB6C3A539" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Collateral Securities Repledged, Delivered, or Used</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed" xlink:label="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_4BCCEEF76F17EF2DED3600ACB6C3A539" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_4BCCEEF76F17EF2DED3600ACB6C3A539" xlink:to="lab_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_4BCCEEF76F17EF2DED3600ACB6C3A539" xlink:type="arc" />
    <link:label id="lab_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B_terseLabel_en-US" xlink:label="lab_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">At Cost Basis [Member]</link:label>
    <link:label id="lab_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B_label_en-US" xlink:label="lab_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">At Cost Basis [Member]</link:label>
    <link:label id="lab_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B_documentation_en-US" xlink:label="lab_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">At Cost Basis [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AtCostBasisMember" xlink:label="loc_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B" xlink:to="lab_agnc_AtCostBasisMember_C5B8442321C131EE22E900D92D37A94B" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_A0778994D197854C22B600D92D37C9C4_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_A0778994D197854C22B600D92D37C9C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Hedging Relationship [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_A0778994D197854C22B600D92D37C9C4_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_A0778994D197854C22B600D92D37C9C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hedging Relationship [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_A0778994D197854C22B600D92D37C9C4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_A0778994D197854C22B600D92D37C9C4" xlink:to="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_A0778994D197854C22B600D92D37C9C4" xlink:type="arc" />
    <link:label id="lab_us-gaap_HedgingRelationshipDomain_EF353BCD6FB23E15632500D92D37DB5A_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingRelationshipDomain_EF353BCD6FB23E15632500D92D37DB5A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Hedging Relationship [Domain]</link:label>
    <link:label id="lab_us-gaap_HedgingRelationshipDomain_EF353BCD6FB23E15632500D92D37DB5A_label_en-US" xlink:label="lab_us-gaap_HedgingRelationshipDomain_EF353BCD6FB23E15632500D92D37DB5A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hedging Relationship [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_EF353BCD6FB23E15632500D92D37DB5A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingRelationshipDomain_EF353BCD6FB23E15632500D92D37DB5A" xlink:to="lab_us-gaap_HedgingRelationshipDomain_EF353BCD6FB23E15632500D92D37DB5A" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueHedgingMember_45D758F4D0E50709188800D92D387244_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueHedgingMember_45D758F4D0E50709188800D92D387244" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Hedging [Member]</link:label>
    <link:label id="lab_us-gaap_FairValueHedgingMember_45D758F4D0E50709188800D92D387244_label_en-US" xlink:label="lab_us-gaap_FairValueHedgingMember_45D758F4D0E50709188800D92D387244" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Hedging [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueHedgingMember" xlink:label="loc_us-gaap_FairValueHedgingMember_45D758F4D0E50709188800D92D387244" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueHedgingMember_45D758F4D0E50709188800D92D387244" xlink:to="lab_us-gaap_FairValueHedgingMember_45D758F4D0E50709188800D92D387244" xlink:type="arc" />
    <link:label id="lab_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB_terseLabel_en-US" xlink:label="lab_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">10 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB_label_en-US" xlink:label="lab_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB_documentation_en-US" xlink:label="lab_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 Year Maturity [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A10YearMaturityMember" xlink:label="loc_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB" xlink:to="lab_agnc_A10YearMaturityMember_330EC0EDF3DCBEC23E2F00D92D39FEBB" xlink:type="arc" />
    <link:label id="lab_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328_terseLabel_en-US" xlink:label="lab_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">5 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328_label_en-US" xlink:label="lab_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">5 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328_documentation_en-US" xlink:label="lab_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">5 Year Maturity [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A5YearMaturityMember" xlink:label="loc_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328" xlink:to="lab_agnc_A5YearMaturityMember_F32ADF72913A7AF28A2000D92D3AA328" xlink:type="arc" />
    <link:label id="lab_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE_terseLabel_en-US" xlink:label="lab_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">7 Years Maturity [Member]</link:label>
    <link:label id="lab_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE_label_en-US" xlink:label="lab_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 Years Maturity [Member]</link:label>
    <link:label id="lab_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE_documentation_en-US" xlink:label="lab_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 Years Maturity [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A7YearsMaturityMember" xlink:label="loc_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE" xlink:to="lab_agnc_A7YearsMaturityMember_4F01B732502F964DADFE00D92D3BC9BE" xlink:type="arc" />
    <link:label id="lab_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF_terseLabel_en-US" xlink:label="lab_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">At Par Value [Member]</link:label>
    <link:label id="lab_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF_label_en-US" xlink:label="lab_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">At Par Value [Member]</link:label>
    <link:label id="lab_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF_documentation_en-US" xlink:label="lab_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">At Par Value [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AtParValueMember" xlink:label="loc_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF" xlink:to="lab_agnc_AtParValueMember_770BA53D53AE19B75C9E00D92D3C1AEF" xlink:type="arc" />
    <link:label id="lab_invest_DerivativeNotionalAmount_87A93B5919D53EA544B700D92D3D2136_negatedTerseLabel_en-US" xlink:label="lab_invest_DerivativeNotionalAmount_87A93B5919D53EA544B700D92D3D2136" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Notional Amount</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_87A93B5919D53EA544B700D92D3D2136" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_DerivativeNotionalAmount_87A93B5919D53EA544B700D92D3D2136" xlink:to="lab_invest_DerivativeNotionalAmount_87A93B5919D53EA544B700D92D3D2136" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeForwardSettlementValue_FA5407C82DB8D2CBDD1900D92D3E8753_negatedTerseLabel_en-US" xlink:label="lab_agnc_DerivativeForwardSettlementValue_FA5407C82DB8D2CBDD1900D92D3E8753" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Forward Settlement Value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_FA5407C82DB8D2CBDD1900D92D3E8753" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeForwardSettlementValue_FA5407C82DB8D2CBDD1900D92D3E8753" xlink:to="lab_agnc_DerivativeForwardSettlementValue_FA5407C82DB8D2CBDD1900D92D3E8753" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_B3BA2545590BC94DC8BE00D92D3E54E7_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_B3BA2545590BC94DC8BE00D92D3E54E7" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Derivative Asset, Fair Value, Gross Asset</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_B3BA2545590BC94DC8BE00D92D3E54E7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_B3BA2545590BC94DC8BE00D92D3E54E7" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_B3BA2545590BC94DC8BE00D92D3E54E7" xlink:type="arc" />
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8_terseLabel_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">U.S. Treasury securities, net</link:label>
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8_label_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">government bonds owned and sold short net</link:label>
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8_documentation_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">government bonds owned and sold short net</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Governmentbondsownedandsoldshortnet" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8" xlink:to="lab_agnc_Governmentbondsownedandsoldshortnet_6DB9AC81C17CE3F6F4C300D92D43E9E8" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfInvestmentsTable_259EF586DC65CF62ACB100EA69005396_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfInvestmentsTable_259EF586DC65CF62ACB100EA69005396" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Investments [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfInvestmentsTable_259EF586DC65CF62ACB100EA69005396_label_en-US" xlink:label="lab_us-gaap_ScheduleOfInvestmentsTable_259EF586DC65CF62ACB100EA69005396" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Investments [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable_259EF586DC65CF62ACB100EA69005396" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_259EF586DC65CF62ACB100EA69005396" xlink:to="lab_us-gaap_ScheduleOfInvestmentsTable_259EF586DC65CF62ACB100EA69005396" xlink:type="arc" />
    <link:label id="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_86C9EE2832C69ACCC02900EA6902AE30_terseLabel_en-US" xlink:label="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_86C9EE2832C69ACCC02900EA6902AE30" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fannie Mae [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_86C9EE2832C69ACCC02900EA6902AE30" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_86C9EE2832C69ACCC02900EA6902AE30" xlink:to="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_86C9EE2832C69ACCC02900EA6902AE30" xlink:type="arc" />
    <link:label id="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_8BF21E92DF490C57626B00EA6902C807_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_8BF21E92DF490C57626B00EA6902C807" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Freddie Mac [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_8BF21E92DF490C57626B00EA6902C807" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_8BF21E92DF490C57626B00EA6902C807" xlink:to="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_8BF21E92DF490C57626B00EA6902C807" xlink:type="arc" />
    <link:label id="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_849EB856890698AF580600EA6903695C_terseLabel_en-US" xlink:label="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_849EB856890698AF580600EA6903695C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Ginnie Mae [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_849EB856890698AF580600EA6903695C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_849EB856890698AF580600EA6903695C" xlink:to="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_849EB856890698AF580600EA6903695C" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_125B35FC7166FBFE528300EA69035AED_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis_125B35FC7166FBFE528300EA69035AED" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Eligible Item or Group for Fair Value Option [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_125B35FC7166FBFE528300EA69035AED" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentAxis_125B35FC7166FBFE528300EA69035AED" xlink:to="lab_us-gaap_FinancialInstrumentAxis_125B35FC7166FBFE528300EA69035AED" xlink:type="arc" />
    <link:label id="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40934C0E1F73F10A541900EA690467A4_terseLabel_en-US" xlink:label="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40934C0E1F73F10A541900EA690467A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value, Option, Eligible Item or Group [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40934C0E1F73F10A541900EA690467A4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40934C0E1F73F10A541900EA690467A4" xlink:to="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40934C0E1F73F10A541900EA690467A4" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableforsaleSecuritiesMember_B16ABCC2924B8800DE2D00EA69042F69_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableforsaleSecuritiesMember_B16ABCC2924B8800DE2D00EA69042F69" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities [Member]</link:label>
    <link:label id="lab_us-gaap_AvailableforsaleSecuritiesMember_B16ABCC2924B8800DE2D00EA69042F69_label_en-US" xlink:label="lab_us-gaap_AvailableforsaleSecuritiesMember_B16ABCC2924B8800DE2D00EA69042F69" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_B16ABCC2924B8800DE2D00EA69042F69" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableforsaleSecuritiesMember_B16ABCC2924B8800DE2D00EA69042F69" xlink:to="lab_us-gaap_AvailableforsaleSecuritiesMember_B16ABCC2924B8800DE2D00EA69042F69" xlink:type="arc" />
    <link:label id="lab_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07_terseLabel_en-US" xlink:label="lab_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Agency securities remeasured at fair value through earnings [Member]</link:label>
    <link:label id="lab_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07_label_en-US" xlink:label="lab_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Agency securities remeasured at fair value through earnings [Member]</link:label>
    <link:label id="lab_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07_documentation_en-US" xlink:label="lab_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Agency Securities Remeasured At Fair Value Through Earnings [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember" xlink:label="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07" xlink:to="lab_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_C0E08BAC5C7FC85B0F0D00EA69047E07" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value [Member]</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8_label_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value [Member]</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8_documentation_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritiesRemeasuredatFairValueMember" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8" xlink:to="lab_agnc_SecuritiesRemeasuredatFairValueMember_616FF9F01C57EFF8A3DB00EA69047EC8" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfInvestmentsLineItems_A47BE42F38ABD2096CDC00EA69045A4E_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfInvestmentsLineItems_A47BE42F38ABD2096CDC00EA69045A4E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Investments [Line Items]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfInvestmentsLineItems_A47BE42F38ABD2096CDC00EA69045A4E_label_en-US" xlink:label="lab_us-gaap_ScheduleOfInvestmentsLineItems_A47BE42F38ABD2096CDC00EA69045A4E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Investments [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfInvestmentsLineItems_A47BE42F38ABD2096CDC00EA69045A4E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_A47BE42F38ABD2096CDC00EA69045A4E" xlink:to="lab_us-gaap_ScheduleOfInvestmentsLineItems_A47BE42F38ABD2096CDC00EA69045A4E" xlink:type="arc" />
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Par value</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Par</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Par</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AvailableForSaleSecuritiesPar" xlink:label="loc_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D" xlink:to="lab_agnc_AvailableForSaleSecuritiesPar_142EE12055E25C9DAA2200EA6905740D" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_3D6561C2D83AF6F5F6C600EA6905529B_negatedLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_3D6561C2D83AF6F5F6C600EA6905529B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Unamortized discount</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_3D6561C2D83AF6F5F6C600EA6905529B_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_3D6561C2D83AF6F5F6C600EA6905529B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Unamortized Discount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_3D6561C2D83AF6F5F6C600EA6905529B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount_3D6561C2D83AF6F5F6C600EA6905529B" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount_3D6561C2D83AF6F5F6C600EA6905529B" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedPremium_A75BEA0B101911000F3F00EA69064F43_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedPremium_A75BEA0B101911000F3F00EA69064F43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unamortized premium</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedPremium_A75BEA0B101911000F3F00EA69064F43_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedPremium_A75BEA0B101911000F3F00EA69064F43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Unamortized Premium</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium_A75BEA0B101911000F3F00EA69064F43" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedPremium_A75BEA0B101911000F3F00EA69064F43" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedPremium_A75BEA0B101911000F3F00EA69064F43" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value through earnings, Amortized Cost</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4_label_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value through earnings, Amortized Cost</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4_documentation_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents the cost of debt and equity securities, which are remeasured at fair value through earnings.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4" xlink:to="lab_agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost_829246563962A541BAD400EA6906B2E4" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Gross Unrealized Gain</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1_label_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Gross Unrealized Gain</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1_documentation_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of unrealized gain before deducting unrealized loss on investments in debt and equity securities remeasured at fair value through earnings</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1" xlink:to="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain_50821DD974AEE4133DFA00EA690601F1" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A_negatedTerseLabel_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Gross Unrealized Loss</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A_label_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Gross Unrealized Loss</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A_documentation_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of unrealized loss before deducting unrealized gain on investments in securities remeasured at fair value through earnings.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A" xlink:to="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss_A08112D71E6E0736AA7500EA6906B98A" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_227958FA08F193DB6A4D00EA6906077C_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_227958FA08F193DB6A4D00EA6906077C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortized cost</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_227958FA08F193DB6A4D00EA6906077C_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_227958FA08F193DB6A4D00EA6906077C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Amortized Cost Basis</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_227958FA08F193DB6A4D00EA6906077C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_227958FA08F193DB6A4D00EA6906077C" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_227958FA08F193DB6A4D00EA6906077C" xlink:type="arc" />
    <link:label id="lab_us-gaap_TradingSecuritiesCost_059035CD4F371C2E72CA00EA6907EE74_verboseLabel_en-US" xlink:label="lab_us-gaap_TradingSecuritiesCost_059035CD4F371C2E72CA00EA6907EE74" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Trading Securities, Cost</link:label>
    <link:label id="lab_us-gaap_TradingSecuritiesCost_059035CD4F371C2E72CA00EA6907EE74_label_en-US" xlink:label="lab_us-gaap_TradingSecuritiesCost_059035CD4F371C2E72CA00EA6907EE74" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Trading Securities, Cost</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TradingSecuritiesCost" xlink:label="loc_us-gaap_TradingSecuritiesCost_059035CD4F371C2E72CA00EA6907EE74" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecuritiesCost_059035CD4F371C2E72CA00EA6907EE74" xlink:to="lab_us-gaap_TradingSecuritiesCost_059035CD4F371C2E72CA00EA6907EE74" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_FC87094D8FE281B4F92200EA69076B3A_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_FC87094D8FE281B4F92200EA69076B3A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gross unrealized gains</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_FC87094D8FE281B4F92200EA69076B3A_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_FC87094D8FE281B4F92200EA69076B3A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Gross Unrealized Gain</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_FC87094D8FE281B4F92200EA69076B3A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_FC87094D8FE281B4F92200EA69076B3A" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_FC87094D8FE281B4F92200EA69076B3A" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_278DC1F7688D4DD976C200EA6907BC9E_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_278DC1F7688D4DD976C200EA6907BC9E" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Gross unrealized losses</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_278DC1F7688D4DD976C200EA6907BC9E_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_278DC1F7688D4DD976C200EA6907BC9E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Gross Unrealized Loss</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_278DC1F7688D4DD976C200EA6907BC9E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_278DC1F7688D4DD976C200EA6907BC9E" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_278DC1F7688D4DD976C200EA6907BC9E" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities remeasured at fair value through earnings, Par Value</link:label>
    <link:label id="lab_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5_label_en-US" xlink:label="lab_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities remeasured at fair value through earnings, Par Value</link:label>
    <link:label id="lab_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5_documentation_en-US" xlink:label="lab_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Securities remeasured at fair value through earnings, Par Value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue" xlink:label="loc_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5" xlink:to="lab_agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue_D688275AAE9C91680CE100EA690759F5" xlink:type="arc" />
    <link:label id="lab_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F_verboseLabel_en-US" xlink:label="lab_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Total agency MBS, at fair value</link:label>
    <link:label id="lab_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F_label_en-US" xlink:label="lab_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Total Agency Securities</link:label>
    <link:label id="lab_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F_documentation_en-US" xlink:label="lab_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents total investment in agency securities at fair value.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TotalAgencySecurities" xlink:label="loc_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F" xlink:to="lab_agnc_TotalAgencySecurities_DC9DE7313640D5C0EB4E00EA69079F7F" xlink:type="arc" />
    <link:label id="lab_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB_terseLabel_en-US" xlink:label="lab_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Securities</link:label>
    <link:label id="lab_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB_label_en-US" xlink:label="lab_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Total Securities</link:label>
    <link:label id="lab_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB_documentation_en-US" xlink:label="lab_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents total investment in securities at fair value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TotalSecurities" xlink:label="loc_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB" xlink:to="lab_agnc_TotalSecurities_ACCE1D08A872BE4194EF00EA6908BEDB" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_C87A22E5F6B711AF99BD00EA6908FB6E_terseLabel_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_C87A22E5F6B711AF99BD00EA6908FB6E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted average coupon</link:label>
    <link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_C87A22E5F6B711AF99BD00EA6908FB6E_label_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_C87A22E5F6B711AF99BD00EA6908FB6E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt, Weighted Average Interest Rate</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_C87A22E5F6B711AF99BD00EA6908FB6E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtWeightedAverageInterestRate_C87A22E5F6B711AF99BD00EA6908FB6E" xlink:to="lab_us-gaap_DebtWeightedAverageInterestRate_C87A22E5F6B711AF99BD00EA6908FB6E" xlink:type="arc" />
    <link:label id="lab_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF_verboseLabel_en-US" xlink:label="lab_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted average yield</link:label>
    <link:label id="lab_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF_label_en-US" xlink:label="lab_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted Average Yield Percentage</link:label>
    <link:label id="lab_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF_documentation_en-US" xlink:label="lab_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">WeightedAverageYieldPercentage</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_WeightedAverageYieldPercentage" xlink:label="loc_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF" xlink:to="lab_agnc_WeightedAverageYieldPercentage_61B38083589DA9597A9300EA6908CEAF" xlink:type="arc" />
    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_E6A2EBF294414626CECE00EA69089FD6_terseLabel_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_E6A2EBF294414626CECE00EA69089FD6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Future Prepayment Rate Assumption Of Investment Portfolio</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_E6A2EBF294414626CECE00EA69089FD6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_E6A2EBF294414626CECE00EA69089FD6" xlink:to="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_E6A2EBF294414626CECE00EA69089FD6" xlink:type="arc" />
    <link:label id="lab_us-gaap_TradingSecuritiesOther_95BC5E62D41671C6A47B00EA69091222_terseLabel_en-US" xlink:label="lab_us-gaap_TradingSecuritiesOther_95BC5E62D41671C6A47B00EA69091222" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Trading Securities, Other</link:label>
    <link:label id="lab_us-gaap_TradingSecuritiesOther_95BC5E62D41671C6A47B00EA69091222_label_en-US" xlink:label="lab_us-gaap_TradingSecuritiesOther_95BC5E62D41671C6A47B00EA69091222" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Trading Securities, Other</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TradingSecuritiesOther" xlink:label="loc_us-gaap_TradingSecuritiesOther_95BC5E62D41671C6A47B00EA69091222" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecuritiesOther_95BC5E62D41671C6A47B00EA69091222" xlink:to="lab_us-gaap_TradingSecuritiesOther_95BC5E62D41671C6A47B00EA69091222" xlink:type="arc" />
    <link:label id="lab_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B_terseLabel_en-US" xlink:label="lab_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Mortgage Backed Securities Amortized Cost</link:label>
    <link:label id="lab_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B_label_en-US" xlink:label="lab_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Mortgage Backed Securities Amortized Cost</link:label>
    <link:label id="lab_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B_documentation_en-US" xlink:label="lab_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Mortgage Backed Securities Amortized Cost</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_MortgageBackedSecuritiesAmortizedCost" xlink:label="loc_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B" xlink:to="lab_agnc_MortgageBackedSecuritiesAmortizedCost_68636C602136855A6F6E00EA6909B59B" xlink:type="arc" />
    <link:label id="lab_us-gaap_HedgingDesignationAxis_458040AD0FB3E8966016AF6EBDCA564D_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_3F21243B3A54575D85630A626C9BC723" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hedging Designation [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_3F21243B3A54575D85630A626C9BC723" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationAxis_3F21243B3A54575D85630A626C9BC723" xlink:to="lab_us-gaap_HedgingDesignationAxis_3F21243B3A54575D85630A626C9BC723" xlink:type="arc" />
    <link:label id="lab_us-gaap_HedgingDesignationDomain_42501E19637D74374CB3AF6EBDCA9E0E_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_CDCF969444B85F7F84A456B8090120DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hedging Designation [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_CDCF969444B85F7F84A456B8090120DB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationDomain_CDCF969444B85F7F84A456B8090120DB" xlink:to="lab_us-gaap_HedgingDesignationDomain_CDCF969444B85F7F84A456B8090120DB" xlink:type="arc" />
    <link:label id="lab_us-gaap_NondesignatedMember_D2A38D1E5C8640373242AF6EBDCAB027_label_en-US" xlink:label="lab_us-gaap_NondesignatedMember_BAB60E6B39AE55288E393E1E9C701F72" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Not Designated as Hedging Instrument [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_BAB60E6B39AE55288E393E1E9C701F72" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NondesignatedMember_BAB60E6B39AE55288E393E1E9C701F72" xlink:to="lab_us-gaap_NondesignatedMember_BAB60E6B39AE55288E393E1E9C701F72" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_9710FE0967531307DD9CAF6EBDCA7C53_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_49258AF6D0425077A37C5E02EBDFD86D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Outstanding Derivatives Not Designated as Hedging Instruments</link:label>
    <link:label id="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_9710FE0967531307DD9CAF6EBDCA7C53_label_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_49258AF6D0425077A37C5E02EBDFD86D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Outstanding Derivatives Not Designated as Hedging Instruments [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_9710FE0967531307DD9CAF6EBDCA7C53_documentation_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_49258AF6D0425077A37C5E02EBDFD86D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Outstanding Derivatives Not Designated as Hedging Instruments [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_49258AF6D0425077A37C5E02EBDFD86D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_49258AF6D0425077A37C5E02EBDFD86D" xlink:to="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_49258AF6D0425077A37C5E02EBDFD86D" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_1D2CE53616AD6F915EFFAF6EBDCBC8F5_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B2867B37B0B3574682C997BF129B5BD8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule Of Interest Rate Swap Agreement By Remaining Maturity</link:label>
    <link:label id="lab_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_1D2CE53616AD6F915EFFAF6EBDCBC8F5_label_en-US" xlink:label="lab_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B2867B37B0B3574682C997BF129B5BD8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule Of Interest Rate Swap Agreement By Remaining Maturity [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_1D2CE53616AD6F915EFFAF6EBDCBC8F5_documentation_en-US" xlink:label="lab_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B2867B37B0B3574682C997BF129B5BD8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule Of Interest Rate Swap Agreement By Remaining Maturity [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" xlink:label="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B2867B37B0B3574682C997BF129B5BD8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B2867B37B0B3574682C997BF129B5BD8" xlink:to="lab_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B2867B37B0B3574682C997BF129B5BD8" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_4840E53C279326EC41BAAF6EBDCB2760_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_35EA86C491F65E5683817EC1BCBEF755" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Interest Rate Swaption Agreements Outstanding</link:label>
    <link:label id="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_4840E53C279326EC41BAAF6EBDCB2760_label_en-US" xlink:label="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_35EA86C491F65E5683817EC1BCBEF755" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Interest Rate Swaption Agreements Outstandin [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_4840E53C279326EC41BAAF6EBDCB2760_documentation_en-US" xlink:label="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_35EA86C491F65E5683817EC1BCBEF755" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Interest Rate Swaption Agreements Outstandin [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" xlink:label="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_35EA86C491F65E5683817EC1BCBEF755" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_35EA86C491F65E5683817EC1BCBEF755" xlink:to="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_35EA86C491F65E5683817EC1BCBEF755" xlink:type="arc" />
    <link:label id="lab_agnc_USgovernmentsecuritiesTableTextBlock_8684C7411AA716CFA275AF6EBDCB63A1_terseLabel_en-US" xlink:label="lab_agnc_USgovernmentsecuritiesTableTextBlock_372A33D245B9530992249D57F0913340" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">US government securities</link:label>
    <link:label id="lab_agnc_USgovernmentsecuritiesTableTextBlock_8684C7411AA716CFA275AF6EBDCB63A1_label_en-US" xlink:label="lab_agnc_USgovernmentsecuritiesTableTextBlock_372A33D245B9530992249D57F0913340" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">US government securities [Table Text Block]</link:label>
    <link:label id="lab_agnc_USgovernmentsecuritiesTableTextBlock_8684C7411AA716CFA275AF6EBDCB63A1_documentation_en-US" xlink:label="lab_agnc_USgovernmentsecuritiesTableTextBlock_372A33D245B9530992249D57F0913340" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">US government securities [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_USgovernmentsecuritiesTableTextBlock" xlink:label="loc_agnc_USgovernmentsecuritiesTableTextBlock_372A33D245B9530992249D57F0913340" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_USgovernmentsecuritiesTableTextBlock_372A33D245B9530992249D57F0913340" xlink:to="lab_agnc_USgovernmentsecuritiesTableTextBlock_372A33D245B9530992249D57F0913340" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_520F0795590A80F99ED7AF6EBDCBD887_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_0AB578C98DE751D8BAD2B2189913426F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Summary of Long and Short Position of Derivative Instruments</link:label>
    <link:label id="lab_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_520F0795590A80F99ED7AF6EBDCBD887_label_en-US" xlink:label="lab_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_0AB578C98DE751D8BAD2B2189913426F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Long and Short Position of Derivative Instruments [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_520F0795590A80F99ED7AF6EBDCBD887_documentation_en-US" xlink:label="lab_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_0AB578C98DE751D8BAD2B2189913426F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Long and Short Position of Derivative Instruments [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_0AB578C98DE751D8BAD2B2189913426F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_0AB578C98DE751D8BAD2B2189913426F" xlink:to="lab_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_0AB578C98DE751D8BAD2B2189913426F" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_F70F25162D2E22F758E5AF6EBDCB060D_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_71D7A0B6DFDA514B9CF2487E55AB86C8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule Of Outstanding Not Designated As Hedging Instruments</link:label>
    <link:label id="lab_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_F70F25162D2E22F758E5AF6EBDCB060D_label_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_71D7A0B6DFDA514B9CF2487E55AB86C8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule Of Outstanding Not Designated As Hedging Instruments [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_F70F25162D2E22F758E5AF6EBDCB060D_documentation_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_71D7A0B6DFDA514B9CF2487E55AB86C8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule Of Outstanding Not Designated As Hedging Instruments [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_71D7A0B6DFDA514B9CF2487E55AB86C8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_71D7A0B6DFDA514B9CF2487E55AB86C8" xlink:to="lab_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_71D7A0B6DFDA514B9CF2487E55AB86C8" xlink:type="arc" />
    <link:label id="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_E46C7821D4DBE9B7DFF7ADEB678AE051_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_8DBC6C4BA51C55BA84002E180933B97E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities by Credit Rating [Table Text Block]</link:label>
    <link:label id="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_E46C7821D4DBE9B7DFF7ADEB678AE051_label_en-US" xlink:label="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_8DBC6C4BA51C55BA84002E180933B97E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities by Credit Rating [Table Text Block]</link:label>
    <link:label id="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_E46C7821D4DBE9B7DFF7ADEB678AE051_documentation_en-US" xlink:label="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_8DBC6C4BA51C55BA84002E180933B97E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Table Text Block] for Securities by Credit Rating [Table]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:label="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_8DBC6C4BA51C55BA84002E180933B97E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_8DBC6C4BA51C55BA84002E180933B97E" xlink:to="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_8DBC6C4BA51C55BA84002E180933B97E" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesTextBlock_9C422F06527E9BE62198ADEB678A1B44_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesTextBlock_1923F229A37752769CF95B6A14CB133B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities [Table Text Block]</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesTextBlock_9C422F06527E9BE62198ADEB678A1B44_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesTextBlock_1923F229A37752769CF95B6A14CB133B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities [Table Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesTextBlock" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_1923F229A37752769CF95B6A14CB133B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_1923F229A37752769CF95B6A14CB133B" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesTextBlock_1923F229A37752769CF95B6A14CB133B" xlink:type="arc" />
    <link:label id="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_F3259D5B47DCFE5ECD29ADEB678A10FD_terseLabel_en-US" xlink:label="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_6F89614571EA506DAF76BE6B130C44F2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Components of Investment Securities</link:label>
    <link:label id="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_F3259D5B47DCFE5ECD29ADEB678A10FD_label_en-US" xlink:label="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_6F89614571EA506DAF76BE6B130C44F2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Components of Investment Securities [Table Text Block]</link:label>
    <link:label id="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_F3259D5B47DCFE5ECD29ADEB678A10FD_documentation_en-US" xlink:label="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_6F89614571EA506DAF76BE6B130C44F2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Components of Investment Securities [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ComponentsOfInvestmentSecuritiesTableTextBlock" xlink:label="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_6F89614571EA506DAF76BE6B130C44F2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_6F89614571EA506DAF76BE6B130C44F2" xlink:to="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_6F89614571EA506DAF76BE6B130C44F2" xlink:type="arc" />
    <link:label id="lab_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_FD9F9DEED841B0BF3632ADEB678A4C73_terseLabel_en-US" xlink:label="lab_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_3BD857DF33A25BAAA5BA6E7CE4DD4C6E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Summary Of Agency Securities Estimated Weighted Average Life Classifications</link:label>
    <link:label id="lab_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_FD9F9DEED841B0BF3632ADEB678A4C73_label_en-US" xlink:label="lab_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_3BD857DF33A25BAAA5BA6E7CE4DD4C6E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Summary of Mortgage Backed Securities Estimated Weighted Average Life Classifications [Table Text Block]</link:label>
    <link:label id="lab_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_FD9F9DEED841B0BF3632ADEB678A4C73_documentation_en-US" xlink:label="lab_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_3BD857DF33A25BAAA5BA6E7CE4DD4C6E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Summary of Mortgage Backed Securities Estimated Weighted Average Life Classifications [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" xlink:label="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_3BD857DF33A25BAAA5BA6E7CE4DD4C6E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_3BD857DF33A25BAAA5BA6E7CE4DD4C6E" xlink:to="lab_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_3BD857DF33A25BAAA5BA6E7CE4DD4C6E" xlink:type="arc" />
    <link:label id="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_A15219022B2A74CC5E8DADEB678A223F_terseLabel_en-US" xlink:label="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8CA5A2923BFE58849D00CCFF41DAA8D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Summary of Continuous Unrealized Loss Position of Available for Sale Securities</link:label>
    <link:label id="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_A15219022B2A74CC5E8DADEB678A223F_label_en-US" xlink:label="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8CA5A2923BFE58849D00CCFF41DAA8D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Summary of Continuous Unrealized Loss Position of Available for Sale Securities [Table Text Block]</link:label>
    <link:label id="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_A15219022B2A74CC5E8DADEB678A223F_documentation_en-US" xlink:label="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8CA5A2923BFE58849D00CCFF41DAA8D9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Summary of Continuous Unrealized Loss Position of Available for Sale Securities [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" xlink:label="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8CA5A2923BFE58849D00CCFF41DAA8D9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8CA5A2923BFE58849D00CCFF41DAA8D9" xlink:to="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8CA5A2923BFE58849D00CCFF41DAA8D9" xlink:type="arc" />
    <link:label id="lab_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_0224C9A59FC94A48A34FADEB678A92DC_terseLabel_en-US" xlink:label="lab_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_EEAE385F00D55011B7AFC3B1C162D2B6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Summary of Net Gain from Sale of Agency Securities</link:label>
    <link:label id="lab_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_0224C9A59FC94A48A34FADEB678A92DC_label_en-US" xlink:label="lab_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_EEAE385F00D55011B7AFC3B1C162D2B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Summary of Net Gain from Sale of Mortgage Backed Securities [Table Text Block]</link:label>
    <link:label id="lab_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_0224C9A59FC94A48A34FADEB678A92DC_documentation_en-US" xlink:label="lab_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_EEAE385F00D55011B7AFC3B1C162D2B6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Summary of Net Gain from Sale of Mortgage Backed Securities [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock" xlink:label="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_EEAE385F00D55011B7AFC3B1C162D2B6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_EEAE385F00D55011B7AFC3B1C162D2B6" xlink:to="lab_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_EEAE385F00D55011B7AFC3B1C162D2B6" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_D1133AEB77D6428D78A7ADEB67C8F128_verboseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_1740AE4301215820A1463F3106CC1F1C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Stockholders' Equity</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_D1133AEB77D6428D78A7ADEB67C8F128_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_1740AE4301215820A1463F3106CC1F1C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stockholders' Equity Note Disclosure [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_1740AE4301215820A1463F3106CC1F1C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_1740AE4301215820A1463F3106CC1F1C" xlink:to="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_1740AE4301215820A1463F3106CC1F1C" xlink:type="arc" />
    <link:label id="lab_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_E94BDB9F4B7B222060AD22AE4F9F4677_terseLabel_en-US" xlink:label="lab_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_98E23319C67357018B6C894CA9646358" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Basis of Presentation and Significant Accounting Policies [Text Block]</link:label>
    <link:label id="lab_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_E94BDB9F4B7B222060AD22AE4F9F4677_label_en-US" xlink:label="lab_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_98E23319C67357018B6C894CA9646358" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Basis of Presentation and Significant Accounting Policies [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_98E23319C67357018B6C894CA9646358" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_98E23319C67357018B6C894CA9646358" xlink:to="lab_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_98E23319C67357018B6C894CA9646358" xlink:type="arc" />
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_2069BD0088CCE2B733ED22AE4F9FBA75_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_C8A17D61CA2A51FE9BEB10641A52D9E7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Goodwill and Intangible Assets, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_2069BD0088CCE2B733ED22AE4F9FBA75_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_C8A17D61CA2A51FE9BEB10641A52D9E7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Goodwill and Intangible Assets, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_C8A17D61CA2A51FE9BEB10641A52D9E7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_C8A17D61CA2A51FE9BEB10641A52D9E7" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_C8A17D61CA2A51FE9BEB10641A52D9E7" xlink:type="arc" />
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_1249802CD526280181B822AE4F9FD2C8_terseLabel_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_7BAF879FE1785345AC7E8EFFF5DF4D29" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Reverse Repurchase Agreements Policy [Policy Text Block]</link:label>
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_1249802CD526280181B822AE4F9FD2C8_label_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_7BAF879FE1785345AC7E8EFFF5DF4D29" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reverse Repurchase Agreements Policy [Policy Text Block]</link:label>
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_1249802CD526280181B822AE4F9FD2C8_documentation_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_7BAF879FE1785345AC7E8EFFF5DF4D29" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Reverse Repurchase Agreements Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock" xlink:label="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_7BAF879FE1785345AC7E8EFFF5DF4D29" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_7BAF879FE1785345AC7E8EFFF5DF4D29" xlink:to="lab_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_7BAF879FE1785345AC7E8EFFF5DF4D29" xlink:type="arc" />
    <link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_30E87CFDAE9F90B0F4DF22AE4F9F0E9B_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_B44B1D47974353BFA787088499A348E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_30E87CFDAE9F90B0F4DF22AE4F9F0E9B_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_B44B1D47974353BFA787088499A348E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_B44B1D47974353BFA787088499A348E2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_B44B1D47974353BFA787088499A348E2" xlink:to="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_B44B1D47974353BFA787088499A348E2" xlink:type="arc" />
    <link:label id="lab_us-gaap_VariableInterestEntityDisclosureTextBlock_3468558421EFDA8E548422AE4F9FE34D_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityDisclosureTextBlock_D8E16AE20D2757C2B2528E55F638DC1E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Variable Interest Entity Disclosure [Text Block]</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityDisclosureTextBlock_3468558421EFDA8E548422AE4F9FE34D_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityDisclosureTextBlock_D8E16AE20D2757C2B2528E55F638DC1E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Variable Interest Entity Disclosure [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:label="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_D8E16AE20D2757C2B2528E55F638DC1E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_D8E16AE20D2757C2B2528E55F638DC1E" xlink:to="lab_us-gaap_VariableInterestEntityDisclosureTextBlock_D8E16AE20D2757C2B2528E55F638DC1E" xlink:type="arc" />
    <link:label id="lab_us-gaap_UseOfEstimates_D3DC8C554FC54F68F62E22AE4FA099C6_terseLabel_en-US" xlink:label="lab_us-gaap_UseOfEstimates_83D040BE50925174A688358D293220EB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Use of Estimates, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_UseOfEstimates_D3DC8C554FC54F68F62E22AE4FA099C6_label_en-US" xlink:label="lab_us-gaap_UseOfEstimates_83D040BE50925174A688358D293220EB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Use of Estimates, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_83D040BE50925174A688358D293220EB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UseOfEstimates_83D040BE50925174A688358D293220EB" xlink:to="lab_us-gaap_UseOfEstimates_83D040BE50925174A688358D293220EB" xlink:type="arc" />
    <link:label id="lab_us-gaap_EarningsPerSharePolicyTextBlock_BC8BBA7EC2C0D521543022AE4FA0847D_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerSharePolicyTextBlock_3204308B7D3F5AA4BF60B9CF92B0F3E6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_EarningsPerSharePolicyTextBlock_BC8BBA7EC2C0D521543022AE4FA0847D_label_en-US" xlink:label="lab_us-gaap_EarningsPerSharePolicyTextBlock_3204308B7D3F5AA4BF60B9CF92B0F3E6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings Per Share, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_3204308B7D3F5AA4BF60B9CF92B0F3E6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerSharePolicyTextBlock_3204308B7D3F5AA4BF60B9CF92B0F3E6" xlink:to="lab_us-gaap_EarningsPerSharePolicyTextBlock_3204308B7D3F5AA4BF60B9CF92B0F3E6" xlink:type="arc" />
    <link:label id="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_6AD3A69082A69307C53A22AE4FA0F19B_terseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_A7C60BF8DA355C4AB2C63E1A4E4DC1A7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Comprehensive Income, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_6AD3A69082A69307C53A22AE4FA0F19B_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_A7C60BF8DA355C4AB2C63E1A4E4DC1A7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Comprehensive Income, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_A7C60BF8DA355C4AB2C63E1A4E4DC1A7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_A7C60BF8DA355C4AB2C63E1A4E4DC1A7" xlink:to="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_A7C60BF8DA355C4AB2C63E1A4E4DC1A7" xlink:type="arc" />
    <link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_211FE200AB462692F16922AE4FA0C3DF_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_C3DF488B1034542296427E90CB4F98F2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_211FE200AB462692F16922AE4FA0C3DF_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_C3DF488B1034542296427E90CB4F98F2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_C3DF488B1034542296427E90CB4F98F2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_C3DF488B1034542296427E90CB4F98F2" xlink:to="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_C3DF488B1034542296427E90CB4F98F2" xlink:type="arc" />
    <link:label id="lab_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_DE6E18A58571D39C132F22AE4FA10FC6_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_42C31528134F577BB2FE7996482C1080" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_DE6E18A58571D39C132F22AE4FA10FC6_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_42C31528134F577BB2FE7996482C1080" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:label="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_42C31528134F577BB2FE7996482C1080" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_42C31528134F577BB2FE7996482C1080" xlink:to="lab_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_42C31528134F577BB2FE7996482C1080" xlink:type="arc" />
    <link:label id="lab_us-gaap_InvestmentPolicyTextBlock_EB89C04E90AD87FA195322AE4FA1E952_verboseLabel_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_89308BCF57D059A588FE7761475230E0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Investment Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_89308BCF57D059A588FE7761475230E0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentPolicyTextBlock_89308BCF57D059A588FE7761475230E0" xlink:to="lab_us-gaap_InvestmentPolicyTextBlock_89308BCF57D059A588FE7761475230E0" xlink:type="arc" />
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_E02F9A9E13D04B1ACD9122AE4FA14412_verboseLabel_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock_3E028CC7A11355A9A58AD527E906D9C1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest Income</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InterestIncomePolicyTextBlock" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_3E028CC7A11355A9A58AD527E906D9C1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestIncomePolicyTextBlock_3E028CC7A11355A9A58AD527E906D9C1" xlink:to="lab_agnc_InterestIncomePolicyTextBlock_3E028CC7A11355A9A58AD527E906D9C1" xlink:type="arc" />
    <link:label id="lab_us-gaap_RepurchaseAndResaleAgreementsPolicy_60DD9115E7A0B9BB982322AE4FA1029B_terseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAndResaleAgreementsPolicy_5FB45D14F37C5EF094F953C9D5063F5C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase and Resale Agreements Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_RepurchaseAndResaleAgreementsPolicy_60DD9115E7A0B9BB982322AE4FA1029B_label_en-US" xlink:label="lab_us-gaap_RepurchaseAndResaleAgreementsPolicy_5FB45D14F37C5EF094F953C9D5063F5C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase and Resale Agreements Policy [Policy Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAndResaleAgreementsPolicy" xlink:label="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_5FB45D14F37C5EF094F953C9D5063F5C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_5FB45D14F37C5EF094F953C9D5063F5C" xlink:to="lab_us-gaap_RepurchaseAndResaleAgreementsPolicy_5FB45D14F37C5EF094F953C9D5063F5C" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativesPolicyTextBlock_AD1EAE1821102665EC0A22AE4FA14DB6_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_3B73041362F05DFFA80CADB7885503F4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instruments</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_3B73041362F05DFFA80CADB7885503F4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesPolicyTextBlock_3B73041362F05DFFA80CADB7885503F4" xlink:to="lab_us-gaap_DerivativesPolicyTextBlock_3B73041362F05DFFA80CADB7885503F4" xlink:type="arc" />
    <link:label id="lab_us-gaap_LossContingencyDisclosures_1DCD72F16E8D5EC46C8122AE4FA1451C_terseLabel_en-US" xlink:label="lab_us-gaap_LossContingencyDisclosures_1C967FF67DEE552BA0743424F7B817D0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Contingencies Disclosure [Text Block]</link:label>
    <link:label id="lab_us-gaap_LossContingencyDisclosures_1DCD72F16E8D5EC46C8122AE4FA1451C_label_en-US" xlink:label="lab_us-gaap_LossContingencyDisclosures_1C967FF67DEE552BA0743424F7B817D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Contingencies Disclosure [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingencyDisclosures" xlink:label="loc_us-gaap_LossContingencyDisclosures_1C967FF67DEE552BA0743424F7B817D0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LossContingencyDisclosures_1C967FF67DEE552BA0743424F7B817D0" xlink:to="lab_us-gaap_LossContingencyDisclosures_1C967FF67DEE552BA0743424F7B817D0" xlink:type="arc" />
    <link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_CBE3497DABF02A96405B22AE4FA10A82_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock_2B19E8C3899D596180EFB3DCD6E6B2C6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Income Tax Disclosure [Text Block]</link:label>
    <link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_CBE3497DABF02A96405B22AE4FA10A82_label_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock_2B19E8C3899D596180EFB3DCD6E6B2C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Tax Disclosure [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_2B19E8C3899D596180EFB3DCD6E6B2C6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxDisclosureTextBlock_2B19E8C3899D596180EFB3DCD6E6B2C6" xlink:to="lab_us-gaap_IncomeTaxDisclosureTextBlock_2B19E8C3899D596180EFB3DCD6E6B2C6" xlink:type="arc" />
    <link:label id="lab_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9_terseLabel_en-US" xlink:label="lab_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Under Prime Broker Agreements [Member]</link:label>
    <link:label id="lab_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9_label_en-US" xlink:label="lab_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Under Prime Broker Agreements [Member]</link:label>
    <link:label id="lab_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9_documentation_en-US" xlink:label="lab_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Under Prime Broker Agreements [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_UnderPrimeBrokerAgreementsMember" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9" xlink:to="lab_agnc_UnderPrimeBrokerAgreementsMember_EE5C95123DA046FF66B100ACB8EAFEA9" xlink:type="arc" />
    <link:label id="lab_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A_terseLabel_en-US" xlink:label="lab_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Excluding Cash Received [Member]</link:label>
    <link:label id="lab_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A_label_en-US" xlink:label="lab_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Excluding Cash Received [Member]</link:label>
    <link:label id="lab_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A_documentation_en-US" xlink:label="lab_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Excluding Cash Received [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ExcludingCashReceivedMember" xlink:label="loc_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A" xlink:to="lab_agnc_ExcludingCashReceivedMember_856B4FE0B047BCD465C600ACB8EAC44A" xlink:type="arc" />
    <link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_63E145F46EB33F3A1F5600ACB8EB4346_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_63E145F46EB33F3A1F5600ACB8EB4346" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Variable Interest Entity, Primary Beneficiary [Member]</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_63E145F46EB33F3A1F5600ACB8EB4346_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_63E145F46EB33F3A1F5600ACB8EB4346" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Variable Interest Entity, Primary Beneficiary [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_63E145F46EB33F3A1F5600ACB8EB4346" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_63E145F46EB33F3A1F5600ACB8EB4346" xlink:to="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_63E145F46EB33F3A1F5600ACB8EB4346" xlink:type="arc" />
    <link:label id="lab_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3_terseLabel_en-US" xlink:label="lab_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Includes Sold But Not Yet Settled Securities [Member]</link:label>
    <link:label id="lab_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3_label_en-US" xlink:label="lab_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Includes Sold But Not Yet Settled Securities [Member]</link:label>
    <link:label id="lab_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3_documentation_en-US" xlink:label="lab_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Includes Sold But Not Yet Settled Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_IncludesSoldButNotYetSettledSecuritiesMember" xlink:label="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3" xlink:to="lab_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0FD90D54E0440AF7960E00ACB8EBDCB3" xlink:type="arc" />
    <link:label id="lab_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE_terseLabel_en-US" xlink:label="lab_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">AAA Non-Agency Mortgage-Backed Securities [Member]</link:label>
    <link:label id="lab_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE_label_en-US" xlink:label="lab_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">AAA Non-Agency Mortgage-Backed Securities [Member]</link:label>
    <link:label id="lab_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE_documentation_en-US" xlink:label="lab_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">AAA rated Non-Agency Mortgage-Backed Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AAANonAgencyMortgageBackedSecuritiesMember" xlink:label="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE" xlink:to="lab_agnc_AAANonAgencyMortgageBackedSecuritiesMember_C604AB5637766E08502400ACB8EB23EE" xlink:type="arc" />
    <link:label id="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_80B1ECFFE6C95C58B96A00ACB8EDB135_terseLabel_en-US" xlink:label="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_80B1ECFFE6C95C58B96A00ACB8EDB135" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Retained Interests in Consolidated VIE's Pledged as Collateral Under Repurchase Agreements</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_80B1ECFFE6C95C58B96A00ACB8EDB135" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_80B1ECFFE6C95C58B96A00ACB8EDB135" xlink:to="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_80B1ECFFE6C95C58B96A00ACB8EDB135" xlink:type="arc" />
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued interest on pledged securities</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Pledged As Collateral Accrued Interest</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:label="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8" xlink:to="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8ED0780604405F4D186000ACB8EE2EB8" xlink:type="arc" />
    <link:label id="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F_terseLabel_en-US" xlink:label="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Fair Value of Securities Pledged and Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F_label_en-US" xlink:label="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Total Fair Value of Securities Pledged and Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F_documentation_en-US" xlink:label="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Total Fair Value of Securities Pledged and Accrued Interest</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest" xlink:label="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F" xlink:to="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_6B3A84D137AEDC6C716B00ACB8EE824F" xlink:type="arc" />
    <link:label id="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658_terseLabel_en-US" xlink:label="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Fair Value Of Agency Securities Pledged And Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658_label_en-US" xlink:label="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Total Fair Value Of Agency Securities Pledged And Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658_documentation_en-US" xlink:label="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Total Fair Value Of Agency Securities Pledged And Accrued Interest</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" xlink:label="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658" xlink:to="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_0726E04299BE6C03CA9C00ACB8EE3658" xlink:type="arc" />
    <link:label id="lab_us-gaap_SubsequentEventsTextBlock_CE42918F0AE697D1851D2B9FC4D70E73_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventsTextBlock_1085DBE72C2D566C96AC020BF7F9CC82" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Subsequent Event</link:label>
    <link:label id="lab_us-gaap_SubsequentEventsTextBlock_CE42918F0AE697D1851D2B9FC4D70E73_label_en-US" xlink:label="lab_us-gaap_SubsequentEventsTextBlock_1085DBE72C2D566C96AC020BF7F9CC82" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Events [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_1085DBE72C2D566C96AC020BF7F9CC82" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventsTextBlock_1085DBE72C2D566C96AC020BF7F9CC82" xlink:to="lab_us-gaap_SubsequentEventsTextBlock_1085DBE72C2D566C96AC020BF7F9CC82" xlink:type="arc" />
    <link:label id="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D_terseLabel_en-US" xlink:label="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Intended annual distribution of taxable net income</link:label>
    <link:label id="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D_label_en-US" xlink:label="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Intended Annual Distribution of Taxable Net Income</link:label>
    <link:label id="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D_documentation_en-US" xlink:label="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Intended Annual Distribution of Taxable Net Income</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_IntendedAnnualDistributionofTaxableNetIncome" xlink:label="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D" xlink:to="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_6D24EA8F99A5531C39B100EA69588F0D" xlink:type="arc" />
    <link:label id="lab_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_CE160FF44AF93C97B393ADEB67D0DFD3_terseLabel_en-US" xlink:label="lab_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_0284C47D30FD55CD93EC8D010F7B91CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Securities</link:label>
    <link:label id="lab_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_CE160FF44AF93C97B393ADEB67D0DFD3_label_en-US" xlink:label="lab_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_0284C47D30FD55CD93EC8D010F7B91CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment In Mortgage-Backed Securities [Text Block]</link:label>
    <link:label id="lab_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_CE160FF44AF93C97B393ADEB67D0DFD3_documentation_en-US" xlink:label="lab_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_0284C47D30FD55CD93EC8D010F7B91CB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of investment in mortgage-backed securities which consist of both securities for which the principal and interest payments are guaranteed by government-sponsored entities ("GSEs") and AAA rated non-agency Securities for which the principal and interest payments are not guaranteed by a GSE.  Mortgage backed securities include securities remeasured at fair value through earnings and available-for-sale securities which consist of all investments in certain debt and equity securities neither classified as trading or held-to-maturity securities</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InvestmentInMortgageBackedSecuritiesTextBlock" xlink:label="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_0284C47D30FD55CD93EC8D010F7B91CB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_0284C47D30FD55CD93EC8D010F7B91CB" xlink:to="lab_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_0284C47D30FD55CD93EC8D010F7B91CB" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShareRepurchaseProgramAxis_85B7A2D310525E2CAF17B8EADFA340A8_terseLabel_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramAxis_98AB857A1AAF52F18060506250192CDF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Plan Name [Axis]</link:label>
    <link:label id="lab_us-gaap_ShareRepurchaseProgramAxis_85B7A2D310525E2CAF17B8EADFA340A8_label_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramAxis_98AB857A1AAF52F18060506250192CDF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Share Repurchase Program [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_98AB857A1AAF52F18060506250192CDF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_98AB857A1AAF52F18060506250192CDF" xlink:to="lab_us-gaap_ShareRepurchaseProgramAxis_98AB857A1AAF52F18060506250192CDF" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShareRepurchaseProgramDomain_8A2E31651C3C66CE5434B8EADFA3B8CD_terseLabel_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramDomain_44C35EA33C085EF291A7B8AB1AF39488" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Share Repurchase Program [Domain]</link:label>
    <link:label id="lab_us-gaap_ShareRepurchaseProgramDomain_8A2E31651C3C66CE5434B8EADFA3B8CD_label_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramDomain_44C35EA33C085EF291A7B8AB1AF39488" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Share Repurchase Program [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_44C35EA33C085EF291A7B8AB1AF39488" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_44C35EA33C085EF291A7B8AB1AF39488" xlink:to="lab_us-gaap_ShareRepurchaseProgramDomain_44C35EA33C085EF291A7B8AB1AF39488" xlink:type="arc" />
    <link:label id="lab_us-gaap_PlanNameDomain_D0B7038F6E79C4CA411EB8EADFA48CFF_terseLabel_en-US" xlink:label="lab_us-gaap_PlanNameDomain_8EA062C7CE5E51468E6C1205EF5EFE9B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Plan Name [Domain]</link:label>
    <link:label id="lab_us-gaap_PlanNameDomain_D0B7038F6E79C4CA411EB8EADFA48CFF_label_en-US" xlink:label="lab_us-gaap_PlanNameDomain_8EA062C7CE5E51468E6C1205EF5EFE9B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Plan Name [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_8EA062C7CE5E51468E6C1205EF5EFE9B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PlanNameDomain_8EA062C7CE5E51468E6C1205EF5EFE9B" xlink:to="lab_us-gaap_PlanNameDomain_8EA062C7CE5E51468E6C1205EF5EFE9B" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1_C575E3C02D64F19BBDFBB8EADFA5134B_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1_A74C7814DA585418BE0B95B1E62C5A23" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Repurchase Program, Authorized Amount</link:label>
    <link:label id="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1_C575E3C02D64F19BBDFBB8EADFA5134B_label_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1_A74C7814DA585418BE0B95B1E62C5A23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stock Repurchase Program, Authorized Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_A74C7814DA585418BE0B95B1E62C5A23" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_A74C7814DA585418BE0B95B1E62C5A23" xlink:to="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1_A74C7814DA585418BE0B95B1E62C5A23" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodShares_34F5D2AA7C805A13D337B8EADFA5AD77_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodShares_5CBB02C140E659439F680405A807B609" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Repurchase of common stock shares</link:label>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodShares_34F5D2AA7C805A13D337B8EADFA5AD77_label_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodShares_5CBB02C140E659439F680405A807B609" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stock Repurchased During Period, Shares</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_5CBB02C140E659439F680405A807B609" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchasedDuringPeriodShares_5CBB02C140E659439F680405A807B609" xlink:to="lab_us-gaap_StockRepurchasedDuringPeriodShares_5CBB02C140E659439F680405A807B609" xlink:type="arc" />
    <link:label id="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare_BC4ACAE0C8004702D140B8EADFA54FB7_terseLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare_CD35E39DE9785118878BF3821E4CBF82" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Average repurchase price (in dollars per share)</link:label>
    <link:label id="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare_BC4ACAE0C8004702D140B8EADFA54FB7_label_en-US" xlink:label="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare_CD35E39DE9785118878BF3821E4CBF82" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Treasury Stock Acquired, Average Cost Per Share</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:label="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_CD35E39DE9785118878BF3821E4CBF82" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_CD35E39DE9785118878BF3821E4CBF82" xlink:to="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare_CD35E39DE9785118878BF3821E4CBF82" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodValue_A9F7D2BC2787BF26B729B8EADFA55ACE_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodValue_D7A43303F3645EBF819250200EE552D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase of common stock, value</link:label>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodValue_A9F7D2BC2787BF26B729B8EADFA55ACE_label_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodValue_D7A43303F3645EBF819250200EE552D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stock Repurchased During Period, Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_D7A43303F3645EBF819250200EE552D9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchasedDuringPeriodValue_D7A43303F3645EBF819250200EE552D9" xlink:to="lab_us-gaap_StockRepurchasedDuringPeriodValue_D7A43303F3645EBF819250200EE552D9" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_5729F11B58C4F226AC5CB8EADFA5B18B_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_31CB1684F6515F518C5E2E4BC403C5B2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Payments for Repurchase of Common Stock</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_5729F11B58C4F226AC5CB8EADFA5B18B_label_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_31CB1684F6515F518C5E2E4BC403C5B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments for Repurchase of Common Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_31CB1684F6515F518C5E2E4BC403C5B2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_31CB1684F6515F518C5E2E4BC403C5B2" xlink:to="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_31CB1684F6515F518C5E2E4BC403C5B2" xlink:type="arc" />
    <link:label id="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_E0687877148685A9438C00ACBB863889_terseLabel_en-US" xlink:label="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_E0687877148685A9438C00ACBB863889" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Risk of interest swap and swaption agreements to stockholders' equity</link:label>
    <link:label id="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_E0687877148685A9438C00ACBB863889_label_en-US" xlink:label="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_E0687877148685A9438C00ACBB863889" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit Derivative, Maximum Exposure, Undiscounted</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditDerivativeMaximumExposureUndiscounted" xlink:label="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_E0687877148685A9438C00ACBB863889" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_E0687877148685A9438C00ACBB863889" xlink:to="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_E0687877148685A9438C00ACBB863889" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentAxis_014FA1D9E591339F4D2F1057532A1971_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_014FA1D9E591339F4D2F1057532A1971" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentAxis_014FA1D9E591339F4D2F1057532A1971_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_014FA1D9E591339F4D2F1057532A1971" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_014FA1D9E591339F4D2F1057532A1971" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentAxis_014FA1D9E591339F4D2F1057532A1971" xlink:to="lab_us-gaap_DebtInstrumentAxis_014FA1D9E591339F4D2F1057532A1971" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_40E1E19EB6A85A9A22AE1057532ADE20_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_40E1E19EB6A85A9A22AE1057532ADE20" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_40E1E19EB6A85A9A22AE1057532ADE20_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_40E1E19EB6A85A9A22AE1057532ADE20" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_40E1E19EB6A85A9A22AE1057532ADE20" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_40E1E19EB6A85A9A22AE1057532ADE20" xlink:to="lab_us-gaap_DebtInstrumentNameDomain_40E1E19EB6A85A9A22AE1057532ADE20" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityOvernightMember_3F2C20A5ED96DBD19E8B1057532B282E_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_3F2C20A5ED96DBD19E8B1057532B282E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityOvernightMember_3F2C20A5ED96DBD19E8B1057532B282E_label_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_3F2C20A5ED96DBD19E8B1057532B282E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_3F2C20A5ED96DBD19E8B1057532B282E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityOvernightMember_3F2C20A5ED96DBD19E8B1057532B282E" xlink:to="lab_us-gaap_MaturityOvernightMember_3F2C20A5ED96DBD19E8B1057532B282E" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_2215E2E0D3A3286680F21057532C0E5A_verboseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_2215E2E0D3A3286680F21057532C0E5A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">30 Days or Less [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_2215E2E0D3A3286680F21057532C0E5A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_2215E2E0D3A3286680F21057532C0E5A" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_2215E2E0D3A3286680F21057532C0E5A" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">1 to 3 Months</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86_label_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86_documentation_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86" xlink:to="lab_agnc_ThirtyOneToNinetyMember_D39A21AFA0CA20D4F1871057532C7F86" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3 to 6 Months</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A_label_en-US" xlink:label="lab_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A_documentation_en-US" xlink:label="lab_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A" xlink:to="lab_agnc_A4to6MonthsMember_AD7E0EBFF07F9410436F1057532C6F9A" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258" xlink:to="lab_agnc_A7to9monthsMember_D74A8492F947C5C6CE981057532C6258" xlink:type="arc" />
    <link:label id="lab_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C" xlink:to="lab_agnc_A10to12MonthsMember_BFDCC44E4171344159C21057532CEF5C" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534" xlink:to="lab_agnc_A13to24MonthsMember_79A68E256D1E167162B31057532C1534" xlink:type="arc" />
    <link:label id="lab_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F" xlink:to="lab_agnc_A25to36monthsMember_AC722029C399E9754A731057532D0B0F" xlink:type="arc" />
    <link:label id="lab_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2_label_en-US" xlink:label="lab_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2_documentation_en-US" xlink:label="lab_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2" xlink:to="lab_agnc_A37to48monthsMember_45BF24345225DA4D75EB1057532D4FD2" xlink:type="arc" />
    <link:label id="lab_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC_label_en-US" xlink:label="lab_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC_documentation_en-US" xlink:label="lab_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC" xlink:to="lab_agnc_A49to60MonthsMember_E66F55E7279A00C129B61057532D4FFC" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_D2F8E32B35CFE31BFC131057532EA984_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_D2F8E32B35CFE31BFC131057532EA984" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_D2F8E32B35CFE31BFC131057532EA984_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_D2F8E32B35CFE31BFC131057532EA984" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate, at Point in Time</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_D2F8E32B35CFE31BFC131057532EA984" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_D2F8E32B35CFE31BFC131057532EA984" xlink:to="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_D2F8E32B35CFE31BFC131057532EA984" xlink:type="arc" />
    <link:label id="lab_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58_terseLabel_en-US" xlink:label="lab_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Credit Rating [Axis]</link:label>
    <link:label id="lab_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58_label_en-US" xlink:label="lab_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit Rating [Axis]</link:label>
    <link:label id="lab_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58_documentation_en-US" xlink:label="lab_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Credit Rating [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CreditRatingAxis" xlink:label="loc_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58" xlink:to="lab_agnc_CreditRatingAxis_5BE8A1D215A48277CFC500EA68D20C58" xlink:type="arc" />
    <link:label id="lab_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5_terseLabel_en-US" xlink:label="lab_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Credit Rating [Domain]</link:label>
    <link:label id="lab_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5_label_en-US" xlink:label="lab_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit Rating [Domain]</link:label>
    <link:label id="lab_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5_documentation_en-US" xlink:label="lab_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Credit Rating [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CreditRatingDomain" xlink:label="loc_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5" xlink:to="lab_agnc_CreditRatingDomain_1E04099CB18895D222CC00EA68D241D5" xlink:type="arc" />
    <link:label id="lab_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2_terseLabel_en-US" xlink:label="lab_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">BBB Rating [Member]</link:label>
    <link:label id="lab_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2_label_en-US" xlink:label="lab_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">BBB Rating [Member]</link:label>
    <link:label id="lab_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2_documentation_en-US" xlink:label="lab_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">BBB Rating [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_BBBRatingMember" xlink:label="loc_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2" xlink:to="lab_agnc_BBBRatingMember_22DBFBD1910A77CF32CA00EA68D318D2" xlink:type="arc" />
    <link:label id="lab_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71_terseLabel_en-US" xlink:label="lab_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">BB Rating [Member]</link:label>
    <link:label id="lab_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71_label_en-US" xlink:label="lab_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">BB Rating [Member]</link:label>
    <link:label id="lab_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71_documentation_en-US" xlink:label="lab_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">BB Rating [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_BBRatingMember" xlink:label="loc_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71" xlink:to="lab_agnc_BBRatingMember_4AACFABBF48F2E5F110700EA68D31E71" xlink:type="arc" />
    <link:label id="lab_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9_terseLabel_en-US" xlink:label="lab_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">AAA Rating [Member]</link:label>
    <link:label id="lab_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9_label_en-US" xlink:label="lab_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">AAA Rating [Member]</link:label>
    <link:label id="lab_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9_documentation_en-US" xlink:label="lab_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">AAA Rating [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AAARatingMember" xlink:label="loc_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9" xlink:to="lab_agnc_AAARatingMember_2411E882BB4FF6C946DE00EA68D327A9" xlink:type="arc" />
    <link:label id="lab_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1_terseLabel_en-US" xlink:label="lab_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">B Rating [Member]</link:label>
    <link:label id="lab_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1_label_en-US" xlink:label="lab_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">B Rating [Member]</link:label>
    <link:label id="lab_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1_documentation_en-US" xlink:label="lab_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">B Rating [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_BRatingMember" xlink:label="loc_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1" xlink:to="lab_agnc_BRatingMember_CC567F23AFA57285751700EA68D4DCC1" xlink:type="arc" />
    <link:label id="lab_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06_terseLabel_en-US" xlink:label="lab_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Not Rated [Member]</link:label>
    <link:label id="lab_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06_label_en-US" xlink:label="lab_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Not Rated [Member]</link:label>
    <link:label id="lab_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06_documentation_en-US" xlink:label="lab_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Not Rated [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NotRatedMember" xlink:label="loc_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06" xlink:to="lab_agnc_NotRatedMember_A0A2009C5133F4963FD900EA68D44F06" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock A, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303_label_en-US" xlink:label="lab_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock A, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303_documentation_en-US" xlink:label="lab_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated values of the preferred A shares.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PreferredStockALiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303" xlink:to="lab_agnc_PreferredStockALiquidationPreferenceValue_EEE5CD1073CC80B2E4CF001747005303" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockSharesAuthorized_EE2B7630B64D8F18562900174701F633_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockSharesAuthorized_EE2B7630B64D8F18562900174701F633" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Shares Authorized</link:label>
    <link:label id="lab_us-gaap_PreferredStockSharesAuthorized_EE2B7630B64D8F18562900174701F633_label_en-US" xlink:label="lab_us-gaap_PreferredStockSharesAuthorized_EE2B7630B64D8F18562900174701F633" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock, Shares Authorized</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_EE2B7630B64D8F18562900174701F633" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockSharesAuthorized_EE2B7630B64D8F18562900174701F633" xlink:to="lab_us-gaap_PreferredStockSharesAuthorized_EE2B7630B64D8F18562900174701F633" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockSharesIssued_656136DCE4938B116CB800174701C390_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockSharesIssued_656136DCE4938B116CB800174701C390" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Shares Issued</link:label>
    <link:label id="lab_us-gaap_PreferredStockSharesIssued_656136DCE4938B116CB800174701C390_label_en-US" xlink:label="lab_us-gaap_PreferredStockSharesIssued_656136DCE4938B116CB800174701C390" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock, Shares Issued</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_656136DCE4938B116CB800174701C390" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockSharesIssued_656136DCE4938B116CB800174701C390" xlink:to="lab_us-gaap_PreferredStockSharesIssued_656136DCE4938B116CB800174701C390" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock B, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A_label_en-US" xlink:label="lab_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock B, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A_documentation_en-US" xlink:label="lab_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated values of the preferred B shares.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PreferredStockBLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A" xlink:to="lab_agnc_PreferredStockBLiquidationPreferenceValue_332A45CA563B2D35150D00174701C93A" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock C, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B_label_en-US" xlink:label="lab_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock C, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B_documentation_en-US" xlink:label="lab_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated values of the preferred C shares.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PreferredStockCLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B" xlink:to="lab_agnc_PreferredStockCLiquidationPreferenceValue_39AA82EB3A10CE2575EE001747026C0B" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_EC945F33306239EE545C00174702F7BB_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare_EC945F33306239EE545C00174702F7BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Par or Stated Value Per Share (in dollars per share)</link:label>
    <link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_EC945F33306239EE545C00174702F7BB_label_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare_EC945F33306239EE545C00174702F7BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock, Par or Stated Value Per Share</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_EC945F33306239EE545C00174702F7BB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockParOrStatedValuePerShare_EC945F33306239EE545C00174702F7BB" xlink:to="lab_us-gaap_CommonStockParOrStatedValuePerShare_EC945F33306239EE545C00174702F7BB" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockSharesAuthorized_64C099BBBFE48CD9BF8500174702D406_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_64C099BBBFE48CD9BF8500174702D406" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesAuthorized_64C099BBBFE48CD9BF8500174702D406_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_64C099BBBFE48CD9BF8500174702D406" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_64C099BBBFE48CD9BF8500174702D406" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesAuthorized_64C099BBBFE48CD9BF8500174702D406" xlink:to="lab_us-gaap_CommonStockSharesAuthorized_64C099BBBFE48CD9BF8500174702D406" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockSharesIssued_C98F91751C8218DC314900174703837F_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_C98F91751C8218DC314900174703837F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Shares, Issued</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesIssued_C98F91751C8218DC314900174703837F_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_C98F91751C8218DC314900174703837F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock, Shares, Issued</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_C98F91751C8218DC314900174703837F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesIssued_C98F91751C8218DC314900174703837F" xlink:to="lab_us-gaap_CommonStockSharesIssued_C98F91751C8218DC314900174703837F" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockSharesOutstanding_6400863D9837121EA025001747036E71_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesOutstanding_6400863D9837121EA025001747036E71" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Shares, Outstanding</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesOutstanding_6400863D9837121EA025001747036E71_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesOutstanding_6400863D9837121EA025001747036E71" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock, Shares, Outstanding</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_6400863D9837121EA025001747036E71" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesOutstanding_6400863D9837121EA025001747036E71" xlink:to="lab_us-gaap_CommonStockSharesOutstanding_6400863D9837121EA025001747036E71" xlink:type="arc" />
    <link:label id="lab_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B_terseLabel_en-US" xlink:label="lab_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Non-Agency Securities Pledged as Collateral</link:label>
    <link:label id="lab_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B_label_en-US" xlink:label="lab_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Non-Agency Securities Pledged as Collateral</link:label>
    <link:label id="lab_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B_documentation_en-US" xlink:label="lab_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The fair value of non-agency securities that serve as collateral for borrowings.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NonAgencySecuritiesPledgedasCollateral" xlink:label="loc_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B" xlink:to="lab_agnc_NonAgencySecuritiesPledgedasCollateral_FD135825EC6A355653C500174703307B" xlink:type="arc" />
    <link:label id="lab_us-gaap_TradingSecuritiesPledgedAsCollateral_9146DF02D99E70DD751700174703D3B1_terseLabel_en-US" xlink:label="lab_us-gaap_TradingSecuritiesPledgedAsCollateral_9146DF02D99E70DD751700174703D3B1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Trading Securities Pledged as Collateral</link:label>
    <link:label id="lab_us-gaap_TradingSecuritiesPledgedAsCollateral_9146DF02D99E70DD751700174703D3B1_label_en-US" xlink:label="lab_us-gaap_TradingSecuritiesPledgedAsCollateral_9146DF02D99E70DD751700174703D3B1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Trading Securities Pledged as Collateral</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TradingSecuritiesPledgedAsCollateral" xlink:label="loc_us-gaap_TradingSecuritiesPledgedAsCollateral_9146DF02D99E70DD751700174703D3B1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecuritiesPledgedAsCollateral_9146DF02D99E70DD751700174703D3B1" xlink:to="lab_us-gaap_TradingSecuritiesPledgedAsCollateral_9146DF02D99E70DD751700174703D3B1" xlink:type="arc" />
    <link:label id="lab_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6_terseLabel_en-US" xlink:label="lab_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets Pledged included in Receivable for Securities Sold</link:label>
    <link:label id="lab_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6_label_en-US" xlink:label="lab_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets Pledged included in Receivable for Securities Sold</link:label>
    <link:label id="lab_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6_documentation_en-US" xlink:label="lab_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Assets Pledged included in Receivable for Securities Sold</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold" xlink:label="loc_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6" xlink:to="lab_agnc_AssetsPledgedIncludedInReceivableForSecuritiesSold_0449CB8C0150C137A3EC00174704BCB6" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_B3A34D0BF5103833489900EA696A71B9_label_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract_B3A34D0BF5103833489900EA696A71B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_B3A34D0BF5103833489900EA696A71B9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_B3A34D0BF5103833489900EA696A71B9" xlink:to="lab_us-gaap_StatementOfCashFlowsAbstract_B3A34D0BF5103833489900EA696A71B9" xlink:type="arc" />
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_BC2EC1B2EE77252B4CC100EA696A1E8E_terseLabel_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_BC2EC1B2EE77252B4CC100EA696A1E8E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents</link:label>
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_BC2EC1B2EE77252B4CC100EA696A1E8E_label_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_BC2EC1B2EE77252B4CC100EA696A1E8E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_BC2EC1B2EE77252B4CC100EA696A1E8E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_BC2EC1B2EE77252B4CC100EA696A1E8E" xlink:to="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_BC2EC1B2EE77252B4CC100EA696A1E8E" xlink:type="arc" />
    <link:label id="lab_us-gaap_InterestPaid_A607AB721B3827884C8D00EA696B50C5_terseLabel_en-US" xlink:label="lab_us-gaap_InterestPaid_A607AB721B3827884C8D00EA696B50C5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Paid</link:label>
    <link:label id="lab_us-gaap_InterestPaid_A607AB721B3827884C8D00EA696B50C5_label_en-US" xlink:label="lab_us-gaap_InterestPaid_A607AB721B3827884C8D00EA696B50C5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Paid</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_A607AB721B3827884C8D00EA696B50C5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestPaid_A607AB721B3827884C8D00EA696B50C5" xlink:to="lab_us-gaap_InterestPaid_A607AB721B3827884C8D00EA696B50C5" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_1948F71169B85A69077F00EA696BDBB9_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_1948F71169B85A69077F00EA696BDBB9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Operating activities:</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_1948F71169B85A69077F00EA696BDBB9_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_1948F71169B85A69077F00EA696BDBB9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Cash Provided by (Used in) Operating Activities [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_1948F71169B85A69077F00EA696BDBB9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_1948F71169B85A69077F00EA696BDBB9" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_1948F71169B85A69077F00EA696BDBB9" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetIncomeLoss_93783D84F3469E01033800EA696B93B0_verboseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_93783D84F3469E01033800EA696B93B0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Net income (loss)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_93783D84F3469E01033800EA696B93B0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLoss_93783D84F3469E01033800EA696B93B0" xlink:to="lab_us-gaap_NetIncomeLoss_93783D84F3469E01033800EA696B93B0" xlink:type="arc" />
    <link:label id="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_4F55229865C1C0D4592300EA696CF071_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_4F55229865C1C0D4592300EA696CF071" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Adjustments to reconcile net income to net cash provided by operating activities:</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_4F55229865C1C0D4592300EA696CF071_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_4F55229865C1C0D4592300EA696CF071" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_4F55229865C1C0D4592300EA696CF071" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_4F55229865C1C0D4592300EA696CF071" xlink:to="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_4F55229865C1C0D4592300EA696CF071" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_AE639D2A180647091BC000EA696C4CD2_negatedLabel_en-US" xlink:label="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_AE639D2A180647091BC000EA696C4CD2" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Amortization of premiums and discounts on mortgage-backed securities, net</link:label>
    <link:label id="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_AE639D2A180647091BC000EA696C4CD2_label_en-US" xlink:label="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_AE639D2A180647091BC000EA696C4CD2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accretion (Amortization) of Discounts and Premiums, Investments</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_AE639D2A180647091BC000EA696C4CD2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_AE639D2A180647091BC000EA696C4CD2" xlink:to="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_AE639D2A180647091BC000EA696C4CD2" xlink:type="arc" />
    <link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_D238932CBD4E50F793F800EA696C32CE_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_D238932CBD4E50F793F800EA696C32CE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortization of intangible assets</link:label>
    <link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_D238932CBD4E50F793F800EA696C32CE_label_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_D238932CBD4E50F793F800EA696C32CE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amortization of Intangible Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_D238932CBD4E50F793F800EA696C32CE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfIntangibleAssets_D238932CBD4E50F793F800EA696C32CE" xlink:to="lab_us-gaap_AmortizationOfIntangibleAssets_D238932CBD4E50F793F800EA696C32CE" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShareBasedCompensation_CA7C75ECDF4C5F1C54E400EA696C8588_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_CA7C75ECDF4C5F1C54E400EA696C8588" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock based compensation</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensation_CA7C75ECDF4C5F1C54E400EA696C8588_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_CA7C75ECDF4C5F1C54E400EA696C8588" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Share-based Compensation</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_CA7C75ECDF4C5F1C54E400EA696C8588" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation_CA7C75ECDF4C5F1C54E400EA696C8588" xlink:to="lab_us-gaap_ShareBasedCompensation_CA7C75ECDF4C5F1C54E400EA696C8588" xlink:type="arc" />
    <link:label id="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_08DFD1F87745F3F75D2A00EA696CE7D1_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_08DFD1F87745F3F75D2A00EA696CE7D1" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Loss on sale of investment securities, net</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_08DFD1F87745F3F75D2A00EA696CE7D1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_08DFD1F87745F3F75D2A00EA696CE7D1" xlink:to="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_08DFD1F87745F3F75D2A00EA696CE7D1" xlink:type="arc" />
    <link:label id="lab_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA_terseLabel_en-US" xlink:label="lab_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unrealized (gain) loss on investment securities measured at fair value through net income, net</link:label>
    <link:label id="lab_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA_label_en-US" xlink:label="lab_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net unrealized gain (loss) on investment securities measured at fair value through net income</link:label>
    <link:label id="lab_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA_documentation_en-US" xlink:label="lab_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Net unrealized gain (loss) on investment securities measured at fair value through net income</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome" xlink:label="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA" xlink:to="lab_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_054066EE0D8E82CBB1EE00EA696C7FDA" xlink:type="arc" />
    <link:label id="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341_verboseLabel_en-US" xlink:label="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">(Gain) loss on derivative instruments and other securities, net</link:label>
    <link:label id="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341_label_en-US" xlink:label="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loss On Derivative Instruments And Trading Securities Net</link:label>
    <link:label id="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341_documentation_en-US" xlink:label="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Loss on derivative instruments and trading securities, net</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341" xlink:to="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_F6BF3E7BFBEC51496EE000EA696D4341" xlink:type="arc" />
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_36ADA88A5AE89121013800EA696D791B_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_36ADA88A5AE89121013800EA696D791B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">(Increase) decrease in other assets</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_36ADA88A5AE89121013800EA696D791B_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_36ADA88A5AE89121013800EA696D791B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Increase (Decrease) in Other Operating Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_36ADA88A5AE89121013800EA696D791B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_36ADA88A5AE89121013800EA696D791B" xlink:to="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_36ADA88A5AE89121013800EA696D791B" xlink:type="arc" />
    <link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_B97183272FC75197D62F00EA696D61B3_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_B97183272FC75197D62F00EA696D61B3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Increase in accounts payable and other accrued liabilities</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_B97183272FC75197D62F00EA696D61B3_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_B97183272FC75197D62F00EA696D61B3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Increase (Decrease) in Accounts Payable and Accrued Liabilities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_B97183272FC75197D62F00EA696D61B3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_B97183272FC75197D62F00EA696D61B3" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_B97183272FC75197D62F00EA696D61B3" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_31ACF0E9DF58B13C154200EA696D5F50_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_31ACF0E9DF58B13C154200EA696D5F50" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net cash provided by operating activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_31ACF0E9DF58B13C154200EA696D5F50_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_31ACF0E9DF58B13C154200EA696D5F50" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Cash Provided by (Used in) Operating Activities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_31ACF0E9DF58B13C154200EA696D5F50" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_31ACF0E9DF58B13C154200EA696D5F50" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_31ACF0E9DF58B13C154200EA696D5F50" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E6DE1B5088B0715E89B600EA696D3ADA_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E6DE1B5088B0715E89B600EA696D3ADA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investing activities:</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E6DE1B5088B0715E89B600EA696D3ADA_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E6DE1B5088B0715E89B600EA696D3ADA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Cash Provided by (Used in) Investing Activities [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E6DE1B5088B0715E89B600EA696D3ADA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E6DE1B5088B0715E89B600EA696D3ADA" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E6DE1B5088B0715E89B600EA696D3ADA" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_F8ADBC4B0A1EA369FF6300EA696EB0DE_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_F8ADBC4B0A1EA369FF6300EA696EB0DE" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Purchases of Agency mortgage-backed securities</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_F8ADBC4B0A1EA369FF6300EA696EB0DE_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_F8ADBC4B0A1EA369FF6300EA696EB0DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments to Acquire Mortgage Backed Securities (MBS) categorized as Available-for-sale</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_F8ADBC4B0A1EA369FF6300EA696EB0DE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_F8ADBC4B0A1EA369FF6300EA696EB0DE" xlink:to="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_F8ADBC4B0A1EA369FF6300EA696EB0DE" xlink:type="arc" />
    <link:label id="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230_negatedTerseLabel_en-US" xlink:label="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Purchases of credit risk transfer and non-Agency securities</link:label>
    <link:label id="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230_label_en-US" xlink:label="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments To Acquire Non- Agency Mortgage Backed Securities</link:label>
    <link:label id="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230_documentation_en-US" xlink:label="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Payments To Acquire Non- Agency Mortgage Backed Securities</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:label="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230" xlink:to="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_1DA341D16389B35E412700EA696E0230" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6BBC49E8713358B60B9300EA696E24A3_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6BBC49E8713358B60B9300EA696E24A3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from sale of Agency mortgage-backed securities</link:label>
    <link:label id="lab_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6BBC49E8713358B60B9300EA696E24A3_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6BBC49E8713358B60B9300EA696E24A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Sale of Mortgage Backed Securities (MBS) categorized as Available-for-sale</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6BBC49E8713358B60B9300EA696E24A3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6BBC49E8713358B60B9300EA696E24A3" xlink:to="lab_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6BBC49E8713358B60B9300EA696E24A3" xlink:type="arc" />
    <link:label id="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B_terseLabel_en-US" xlink:label="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from sale of credit risk transfer and non-Agency securities</link:label>
    <link:label id="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B_label_en-US" xlink:label="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from sale of Credit Risk Transfer and non-Agency securities</link:label>
    <link:label id="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B_documentation_en-US" xlink:label="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Proceeds from sale of CRT and non-Agency securities</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities" xlink:label="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B" xlink:to="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_F78CBEFF0E8140A8779B00EA696ED32B" xlink:type="arc" />
    <link:label id="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39_terseLabel_en-US" xlink:label="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Principal collections on Agency mortgage-backed securities</link:label>
    <link:label id="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39_label_en-US" xlink:label="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds From Principal Collection Of Mortgage Backed Securities Categorized As Available For Sale</link:label>
    <link:label id="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39_documentation_en-US" xlink:label="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The cash inflow from collection of principal from borrowers on mortgage backed securities held.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39" xlink:to="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_BD9F9BB731CBE3BAAA3B00EA696FBD39" xlink:type="arc" />
    <link:label id="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826_terseLabel_en-US" xlink:label="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Principal collections on credit risk transfer and non-Agency securities</link:label>
    <link:label id="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826_label_en-US" xlink:label="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Principal collections on credit risk transfer and non-Agency securities</link:label>
    <link:label id="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826_documentation_en-US" xlink:label="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Principal collections on CRT and non-Agency securities</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:label="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826" xlink:to="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_9EAF3C6FA196E8B12EAC00EA696F5826" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_0896FF5CAC728922DDCC00EA696FEE90_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_0896FF5CAC728922DDCC00EA696FEE90" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Payments on U.S. Treasury securities</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_0896FF5CAC728922DDCC00EA696FEE90_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_0896FF5CAC728922DDCC00EA696FEE90" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments to Acquire Available-for-sale Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_0896FF5CAC728922DDCC00EA696FEE90" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_0896FF5CAC728922DDCC00EA696FEE90" xlink:to="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_0896FF5CAC728922DDCC00EA696FEE90" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_3EC73CAA7093A4CBB91000EA696FDBED_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_3EC73CAA7093A4CBB91000EA696FDBED" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from U.S. Treasury securities</link:label>
    <link:label id="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_3EC73CAA7093A4CBB91000EA696FDBED_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_3EC73CAA7093A4CBB91000EA696FDBED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Sale of Available-for-sale Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_3EC73CAA7093A4CBB91000EA696FDBED" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_3EC73CAA7093A4CBB91000EA696FDBED" xlink:to="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_3EC73CAA7093A4CBB91000EA696FDBED" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_D5F7F09EFC7FBA7843BD00EA696F7ACE_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_D5F7F09EFC7FBA7843BD00EA696F7ACE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net proceeds from (payments on) reverse repurchase agreements</link:label>
    <link:label id="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_D5F7F09EFC7FBA7843BD00EA696F7ACE_label_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_D5F7F09EFC7FBA7843BD00EA696F7ACE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from (Payments for) Securities Purchased under Agreements to Resell</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:label="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_D5F7F09EFC7FBA7843BD00EA696F7ACE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_D5F7F09EFC7FBA7843BD00EA696F7ACE" xlink:to="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_D5F7F09EFC7FBA7843BD00EA696F7ACE" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_FB10E4810A53DE8FE4AA00EA696F0E73_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_FB10E4810A53DE8FE4AA00EA696F0E73" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Net proceeds from (payments on) derivative instruments</link:label>
    <link:label id="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_FB10E4810A53DE8FE4AA00EA696F0E73_label_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_FB10E4810A53DE8FE4AA00EA696F0E73" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments for (Proceeds from) Derivative Instrument, Financing Activities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_FB10E4810A53DE8FE4AA00EA696F0E73" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_FB10E4810A53DE8FE4AA00EA696F0E73" xlink:to="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_FB10E4810A53DE8FE4AA00EA696F0E73" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsToAcquireMarketableSecurities_394703F4B2FA26E09E2100EA696F1564_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMarketableSecurities_394703F4B2FA26E09E2100EA696F1564" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Purchases of REIT equity securities</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireMarketableSecurities_394703F4B2FA26E09E2100EA696F1564_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMarketableSecurities_394703F4B2FA26E09E2100EA696F1564" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments to Acquire Marketable Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_394703F4B2FA26E09E2100EA696F1564" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireMarketableSecurities_394703F4B2FA26E09E2100EA696F1564" xlink:to="lab_us-gaap_PaymentsToAcquireMarketableSecurities_394703F4B2FA26E09E2100EA696F1564" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_7956DEEBDDC7DA8A264300EA69706F7C_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_7956DEEBDDC7DA8A264300EA69706F7C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from sale of REIT equity securities</link:label>
    <link:label id="lab_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_7956DEEBDDC7DA8A264300EA69706F7C_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_7956DEEBDDC7DA8A264300EA69706F7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Sale and Maturity of Marketable Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_7956DEEBDDC7DA8A264300EA69706F7C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_7956DEEBDDC7DA8A264300EA69706F7C" xlink:to="lab_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_7956DEEBDDC7DA8A264300EA69706F7C" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4B772138B311819FC20C00EA6970532D_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4B772138B311819FC20C00EA6970532D" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Purchase of AGNC Mortgage Management, LLC, net of cash acquired</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4B772138B311819FC20C00EA6970532D_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4B772138B311819FC20C00EA6970532D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments to Acquire Businesses, Net of Cash Acquired</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4B772138B311819FC20C00EA6970532D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4B772138B311819FC20C00EA6970532D" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4B772138B311819FC20C00EA6970532D" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_007F54DE0F7AD3C46CDB00EA69706EF3_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_007F54DE0F7AD3C46CDB00EA69706EF3" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net cash provided by investing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_007F54DE0F7AD3C46CDB00EA69706EF3_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_007F54DE0F7AD3C46CDB00EA69706EF3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Cash Provided by (Used in) Investing Activities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_007F54DE0F7AD3C46CDB00EA69706EF3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_007F54DE0F7AD3C46CDB00EA69706EF3" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_007F54DE0F7AD3C46CDB00EA69706EF3" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A9C7E3A4E5B809DC5F9500EA6970610D_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A9C7E3A4E5B809DC5F9500EA6970610D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Financing activities:</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A9C7E3A4E5B809DC5F9500EA6970610D_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A9C7E3A4E5B809DC5F9500EA6970610D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Cash Provided by (Used in) Financing Activities [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A9C7E3A4E5B809DC5F9500EA6970610D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A9C7E3A4E5B809DC5F9500EA6970610D" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A9C7E3A4E5B809DC5F9500EA6970610D" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromShortTermDebt_B17A0BAC25DF8B4A54C000EA697074F7_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromShortTermDebt_B17A0BAC25DF8B4A54C000EA697074F7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from repurchase arrangements</link:label>
    <link:label id="lab_us-gaap_ProceedsFromShortTermDebt_B17A0BAC25DF8B4A54C000EA697074F7_label_en-US" xlink:label="lab_us-gaap_ProceedsFromShortTermDebt_B17A0BAC25DF8B4A54C000EA697074F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Short-term Debt</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_B17A0BAC25DF8B4A54C000EA697074F7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromShortTermDebt_B17A0BAC25DF8B4A54C000EA697074F7" xlink:to="lab_us-gaap_ProceedsFromShortTermDebt_B17A0BAC25DF8B4A54C000EA697074F7" xlink:type="arc" />
    <link:label id="lab_us-gaap_RepaymentsOfShortTermDebt_C87E72C1A7DE26387E7A00EA6971F522_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfShortTermDebt_C87E72C1A7DE26387E7A00EA6971F522" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Payments on repurchase agreements</link:label>
    <link:label id="lab_us-gaap_RepaymentsOfShortTermDebt_C87E72C1A7DE26387E7A00EA6971F522_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfShortTermDebt_C87E72C1A7DE26387E7A00EA6971F522" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repayments of Short-term Debt</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_C87E72C1A7DE26387E7A00EA6971F522" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfShortTermDebt_C87E72C1A7DE26387E7A00EA6971F522" xlink:to="lab_us-gaap_RepaymentsOfShortTermDebt_C87E72C1A7DE26387E7A00EA6971F522" xlink:type="arc" />
    <link:label id="lab_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_01F0A07040F17C2D5A5100EA6971ED4D_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_01F0A07040F17C2D5A5100EA6971ED4D" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Payments on Federal Home Loan Bank advances</link:label>
    <link:label id="lab_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_01F0A07040F17C2D5A5100EA6971ED4D_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_01F0A07040F17C2D5A5100EA6971ED4D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repayments of Federal Home Loan Bank Borrowings</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings" xlink:label="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_01F0A07040F17C2D5A5100EA6971ED4D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_01F0A07040F17C2D5A5100EA6971ED4D" xlink:to="lab_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_01F0A07040F17C2D5A5100EA6971ED4D" xlink:type="arc" />
    <link:label id="lab_us-gaap_RepaymentsOfOtherDebt_7695FF9922360275596B00EA69715513_negatedLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfOtherDebt_7695FF9922360275596B00EA69715513" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Payments on debt of consolidated variable interest entities</link:label>
    <link:label id="lab_us-gaap_RepaymentsOfOtherDebt_7695FF9922360275596B00EA69715513_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfOtherDebt_7695FF9922360275596B00EA69715513" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repayments of Other Debt</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepaymentsOfOtherDebt" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_7695FF9922360275596B00EA69715513" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfOtherDebt_7695FF9922360275596B00EA69715513" xlink:to="lab_us-gaap_RepaymentsOfOtherDebt_7695FF9922360275596B00EA69715513" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_4C61132CF061F0D3CC8700EA69713E4E_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_4C61132CF061F0D3CC8700EA69713E4E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Net proceeds from preferred stock issuance</link:label>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_4C61132CF061F0D3CC8700EA69713E4E_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_4C61132CF061F0D3CC8700EA69713E4E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Issuance of Preferred Stock and Preference Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_4C61132CF061F0D3CC8700EA69713E4E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_4C61132CF061F0D3CC8700EA69713E4E" xlink:to="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_4C61132CF061F0D3CC8700EA69713E4E" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_E81F90DE7DE071B04D2100EA69713204_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_E81F90DE7DE071B04D2100EA69713204" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Payment for preferred stock redemption</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_E81F90DE7DE071B04D2100EA69713204_label_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_E81F90DE7DE071B04D2100EA69713204" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments for Repurchase of Redeemable Preferred Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_E81F90DE7DE071B04D2100EA69713204" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_E81F90DE7DE071B04D2100EA69713204" xlink:to="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_E81F90DE7DE071B04D2100EA69713204" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfCommonStock_189F0093D1CD807BB0F500EA6972B71E_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfCommonStock_189F0093D1CD807BB0F500EA6972B71E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net proceeds from common stock issuances</link:label>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfCommonStock_189F0093D1CD807BB0F500EA6972B71E_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfCommonStock_189F0093D1CD807BB0F500EA6972B71E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Issuance of Common Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_189F0093D1CD807BB0F500EA6972B71E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_189F0093D1CD807BB0F500EA6972B71E" xlink:to="lab_us-gaap_ProceedsFromIssuanceOfCommonStock_189F0093D1CD807BB0F500EA6972B71E" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsOfDividends_2F71D9836596CB6270EA00EA6972AF08_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsOfDividends_2F71D9836596CB6270EA00EA6972AF08" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Cash dividends paid</link:label>
    <link:label id="lab_us-gaap_PaymentsOfDividends_2F71D9836596CB6270EA00EA6972AF08_label_en-US" xlink:label="lab_us-gaap_PaymentsOfDividends_2F71D9836596CB6270EA00EA6972AF08" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments of Dividends</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_2F71D9836596CB6270EA00EA6972AF08" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsOfDividends_2F71D9836596CB6270EA00EA6972AF08" xlink:to="lab_us-gaap_PaymentsOfDividends_2F71D9836596CB6270EA00EA6972AF08" xlink:type="arc" />
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_3243179C3B428CA0107C00EA69722E33_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_3243179C3B428CA0107C00EA69722E33" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net cash used in financing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_3243179C3B428CA0107C00EA69722E33_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_3243179C3B428CA0107C00EA69722E33" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Cash Provided by (Used in) Financing Activities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3243179C3B428CA0107C00EA69722E33" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3243179C3B428CA0107C00EA69722E33" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_3243179C3B428CA0107C00EA69722E33" xlink:type="arc" />
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_FAF2B8EA81D1EA5E4EFF00EA6972F59E_totalLabel_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_FAF2B8EA81D1EA5E4EFF00EA6972F59E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net change in cash and cash equivalents</link:label>
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_FAF2B8EA81D1EA5E4EFF00EA6972F59E_label_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_FAF2B8EA81D1EA5E4EFF00EA6972F59E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_FAF2B8EA81D1EA5E4EFF00EA6972F59E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_FAF2B8EA81D1EA5E4EFF00EA6972F59E" xlink:to="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_FAF2B8EA81D1EA5E4EFF00EA6972F59E" xlink:type="arc" />
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_FA477F9BF88B76B00A6100EA69729DB1_periodEndLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_FA477F9BF88B76B00A6100EA69729DB1" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Cash and cash equivalents at end of period</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_FA477F9BF88B76B00A6100EA69729DB1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_FA477F9BF88B76B00A6100EA69729DB1" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_FA477F9BF88B76B00A6100EA69729DB1" xlink:type="arc" />
    <link:label id="lab_us-gaap_IncomeTaxesPaid_83524285DA4DA19F6DCF00EA6972D7DC_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaid_83524285DA4DA19F6DCF00EA6972D7DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Income Taxes Paid</link:label>
    <link:label id="lab_us-gaap_IncomeTaxesPaid_83524285DA4DA19F6DCF00EA6972D7DC_label_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaid_83524285DA4DA19F6DCF00EA6972D7DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Taxes Paid</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_83524285DA4DA19F6DCF00EA6972D7DC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxesPaid_83524285DA4DA19F6DCF00EA6972D7DC" xlink:to="lab_us-gaap_IncomeTaxesPaid_83524285DA4DA19F6DCF00EA6972D7DC" xlink:type="arc" />
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_A74B3497309D0BE06948ADEB683BE967_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_AA8A9A20C2575416A1AB4078CB00F8F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances by Maturity [Abstract]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_A74B3497309D0BE06948ADEB683BE967_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_AA8A9A20C2575416A1AB4078CB00F8F0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances by Maturity [Abstract]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_AA8A9A20C2575416A1AB4078CB00F8F0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_AA8A9A20C2575416A1AB4078CB00F8F0" xlink:to="lab_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_AA8A9A20C2575416A1AB4078CB00F8F0" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfShortTermDebtTable_9461DAF0DE7A7D7DB741ADEB683B07D0_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfShortTermDebtTable_3844F2748C1F5D8EA630520263DECDE2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Short-term Debt [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfShortTermDebtTable_9461DAF0DE7A7D7DB741ADEB683B07D0_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShortTermDebtTable_3844F2748C1F5D8EA630520263DECDE2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Short-term Debt [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfShortTermDebtTable" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable_3844F2748C1F5D8EA630520263DECDE2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_3844F2748C1F5D8EA630520263DECDE2" xlink:to="lab_us-gaap_ScheduleOfShortTermDebtTable_3844F2748C1F5D8EA630520263DECDE2" xlink:type="arc" />
    <link:label id="lab_agnc_A37to48monthsMember_D32D7E2DA1262CE49AB1ADEB683C1464_terseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_3652A3F4EDCD5ADB85E276105E680EEC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_3652A3F4EDCD5ADB85E276105E680EEC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A37to48monthsMember_3652A3F4EDCD5ADB85E276105E680EEC" xlink:to="lab_agnc_A37to48monthsMember_3652A3F4EDCD5ADB85E276105E680EEC" xlink:type="arc" />
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_C9C2A6AF116953B65447ADEB683C38D3_terseLabel_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_790B03B07879508382D93B08386E637B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_C9C2A6AF116953B65447ADEB683C38D3_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_790B03B07879508382D93B08386E637B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_C9C2A6AF116953B65447ADEB683C38D3_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_790B03B07879508382D93B08386E637B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_790B03B07879508382D93B08386E637B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_790B03B07879508382D93B08386E637B" xlink:to="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_790B03B07879508382D93B08386E637B" xlink:type="arc" />
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_8CD6A3A763B42530CE97ADEB683C467A_terseLabel_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_F1C0B29E762A56DAA14612978C76487D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Domain]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_8CD6A3A763B42530CE97ADEB683C467A_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_F1C0B29E762A56DAA14612978C76487D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Domain]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_8CD6A3A763B42530CE97ADEB683C467A_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_F1C0B29E762A56DAA14612978C76487D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_F1C0B29E762A56DAA14612978C76487D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_F1C0B29E762A56DAA14612978C76487D" xlink:to="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_F1C0B29E762A56DAA14612978C76487D" xlink:type="arc" />
    <link:label id="lab_agnc_A49to60MonthsMember_A848A833CA8747CDA2CDADEB683C4EB5_terseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_50C046692A41568CB8F7B56FAF2FB86E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_50C046692A41568CB8F7B56FAF2FB86E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_50C046692A41568CB8F7B56FAF2FB86E" xlink:to="lab_agnc_A49to60MonthsMember_50C046692A41568CB8F7B56FAF2FB86E" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_B2E7EB593FBD704FCD25ADEB683CE86F_terseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_47D89B1EC950521EAE4AA19F4DD108A9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_47D89B1EC950521EAE4AA19F4DD108A9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_47D89B1EC950521EAE4AA19F4DD108A9" xlink:to="lab_agnc_ThirtyOneToNinetyMember_47D89B1EC950521EAE4AA19F4DD108A9" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_81EE3BB1BC2105A974C3ADEB683C2F51_verboseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_67E9B33A1CFA51B9AEE3C6345FB237AB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_67E9B33A1CFA51B9AEE3C6345FB237AB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_67E9B33A1CFA51B9AEE3C6345FB237AB" xlink:to="lab_agnc_A4to6MonthsMember_67E9B33A1CFA51B9AEE3C6345FB237AB" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_F9C1742A060C8E517990ADEB683CA944_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis_00F41E29FD5250D1BBE76CFC34C74E30" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_F9C1742A060C8E517990ADEB683CA944_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis_00F41E29FD5250D1BBE76CFC34C74E30" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_00F41E29FD5250D1BBE76CFC34C74E30" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_00F41E29FD5250D1BBE76CFC34C74E30" xlink:to="lab_us-gaap_ShortTermDebtTypeAxis_00F41E29FD5250D1BBE76CFC34C74E30" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtTypeDomain_2F069B1F9C8D600AF471ADEB683C443F_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeDomain_4E70D3515AF2504F932ECBE8C9726023" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Domain]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtTypeDomain_2F069B1F9C8D600AF471ADEB683C443F_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeDomain_4E70D3515AF2504F932ECBE8C9726023" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_4E70D3515AF2504F932ECBE8C9726023" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_4E70D3515AF2504F932ECBE8C9726023" xlink:to="lab_us-gaap_ShortTermDebtTypeDomain_4E70D3515AF2504F932ECBE8C9726023" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtLineItems_C9769CADCA98D90AF455ADEB683C462D_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems_67BFB075AAE054BEB480C5F73C3BF07C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtLineItems_C9769CADCA98D90AF455ADEB683C462D_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems_67BFB075AAE054BEB480C5F73C3BF07C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortTermDebtLineItems" xlink:label="loc_us-gaap_ShortTermDebtLineItems_67BFB075AAE054BEB480C5F73C3BF07C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtLineItems_67BFB075AAE054BEB480C5F73C3BF07C" xlink:to="lab_us-gaap_ShortTermDebtLineItems_67BFB075AAE054BEB480C5F73C3BF07C" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_A2E8F9ED75B701D42BA4ADEB683C5498_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_3B54CC185D0C535F9E6244AEED0D9002" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Percentage Bearing Fixed Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_A2E8F9ED75B701D42BA4ADEB683C5498_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_3B54CC185D0C535F9E6244AEED0D9002" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Percentage Bearing Fixed Interest Rate</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortTermDebtPercentageBearingFixedInterestRate" xlink:label="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_3B54CC185D0C535F9E6244AEED0D9002" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_3B54CC185D0C535F9E6244AEED0D9002" xlink:to="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_3B54CC185D0C535F9E6244AEED0D9002" xlink:type="arc" />
    <link:label id="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_733D08C0FBFA02F55366ADEB683D8E70_terseLabel_en-US" xlink:label="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_2AA208D0CFCD5FEC96419F2E99FAE856" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Advances from Federal Home Loan Banks</link:label>
    <link:label id="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_733D08C0FBFA02F55366ADEB683D8E70_label_en-US" xlink:label="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_2AA208D0CFCD5FEC96419F2E99FAE856" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Advances from Federal Home Loan Banks</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_2AA208D0CFCD5FEC96419F2E99FAE856" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_2AA208D0CFCD5FEC96419F2E99FAE856" xlink:to="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_2AA208D0CFCD5FEC96419F2E99FAE856" xlink:type="arc" />
    <link:label id="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_EFB0979E243EA2E951CAFCA565B62FC4_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_EFB0979E243EA2E951CAFCA565B62FC4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2017</link:label>
    <link:label id="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_EFB0979E243EA2E951CAFCA565B62FC4_label_en-US" xlink:label="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_EFB0979E243EA2E951CAFCA565B62FC4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Deferred Gain (Loss) on Discontinuation of Interest Rate Fair Value Hedge</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_EFB0979E243EA2E951CAFCA565B62FC4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_EFB0979E243EA2E951CAFCA565B62FC4" xlink:to="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_EFB0979E243EA2E951CAFCA565B62FC4" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_23BA8942C8C11FB18302FCA565B8D677_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_23BA8942C8C11FB18302FCA565B8D677" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_23BA8942C8C11FB18302FCA565B8D677" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_23BA8942C8C11FB18302FCA565B8D677" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_23BA8942C8C11FB18302FCA565B8D677" xlink:type="arc" />
    <link:label id="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_E6E3815F70EE0F82368AFCA565B85EE2_terseLabel_en-US" xlink:label="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_E6E3815F70EE0F82368AFCA565B85EE2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amounts reclassified from accumulated OCI</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_E6E3815F70EE0F82368AFCA565B85EE2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_E6E3815F70EE0F82368AFCA565B85EE2" xlink:to="lab_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_E6E3815F70EE0F82368AFCA565B85EE2" xlink:type="arc" />
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_620C9BA64FD9054EC693FCA565B989DB_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_620C9BA64FD9054EC693FCA565B989DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amounts reclassified from accumulated OCI</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_620C9BA64FD9054EC693FCA565B989DB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_620C9BA64FD9054EC693FCA565B989DB" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_620C9BA64FD9054EC693FCA565B989DB" xlink:type="arc" />
    <link:label id="lab_us-gaap_FixedIncomeSecuritiesMember_EA3A081BBD0A9CF2D32DB3DE02163FED_terseLabel_en-US" xlink:label="lab_us-gaap_FixedIncomeSecuritiesMember_5E25BC50F1325FFB94EED827AF0873F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fixed Income Securities [Member]</link:label>
    <link:label id="lab_us-gaap_FixedIncomeSecuritiesMember_EA3A081BBD0A9CF2D32DB3DE02163FED_label_en-US" xlink:label="lab_us-gaap_FixedIncomeSecuritiesMember_5E25BC50F1325FFB94EED827AF0873F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fixed Income Securities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FixedIncomeSecuritiesMember" xlink:label="loc_us-gaap_FixedIncomeSecuritiesMember_5E25BC50F1325FFB94EED827AF0873F0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FixedIncomeSecuritiesMember_5E25BC50F1325FFB94EED827AF0873F0" xlink:to="lab_us-gaap_FixedIncomeSecuritiesMember_5E25BC50F1325FFB94EED827AF0873F0" xlink:type="arc" />
    <link:label id="lab_agnc_AdjustableRateMember_E71F7B705DD95D66DBEBB3DE0216230B_terseLabel_en-US" xlink:label="lab_agnc_AdjustableRateMember_F5F03DDBF2F951ADADC3638237A80481" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Adjustable-Rate [Member]</link:label>
    <link:label id="lab_agnc_AdjustableRateMember_E71F7B705DD95D66DBEBB3DE0216230B_label_en-US" xlink:label="lab_agnc_AdjustableRateMember_F5F03DDBF2F951ADADC3638237A80481" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Adjustable-Rate [Member]</link:label>
    <link:label id="lab_agnc_AdjustableRateMember_E71F7B705DD95D66DBEBB3DE0216230B_documentation_en-US" xlink:label="lab_agnc_AdjustableRateMember_F5F03DDBF2F951ADADC3638237A80481" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Adjustable-Rate [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AdjustableRateMember" xlink:label="loc_agnc_AdjustableRateMember_F5F03DDBF2F951ADADC3638237A80481" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AdjustableRateMember_F5F03DDBF2F951ADADC3638237A80481" xlink:to="lab_agnc_AdjustableRateMember_F5F03DDBF2F951ADADC3638237A80481" xlink:type="arc" />
    <link:label id="lab_us-gaap_CollateralizedMortgageObligationsMember_D499D9A51D6678A34D4CB3DE0216C6C1_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralizedMortgageObligationsMember_B47635DF58F5532DA06BC13B0C4D4EDD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Collateralized Mortgage Obligations [Member]</link:label>
    <link:label id="lab_us-gaap_CollateralizedMortgageObligationsMember_D499D9A51D6678A34D4CB3DE0216C6C1_label_en-US" xlink:label="lab_us-gaap_CollateralizedMortgageObligationsMember_B47635DF58F5532DA06BC13B0C4D4EDD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Collateralized Mortgage Obligations [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CollateralizedMortgageObligationsMember" xlink:label="loc_us-gaap_CollateralizedMortgageObligationsMember_B47635DF58F5532DA06BC13B0C4D4EDD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollateralizedMortgageObligationsMember_B47635DF58F5532DA06BC13B0C4D4EDD" xlink:to="lab_us-gaap_CollateralizedMortgageObligationsMember_B47635DF58F5532DA06BC13B0C4D4EDD" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecurities_7D06C9B4C3B6BAE169DCB3DE021706FD_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_4FFB95F3A004502DA4B4B65F2A8AE9D1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair value</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecurities_7D06C9B4C3B6BAE169DCB3DE021706FD_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_4FFB95F3A004502DA4B4B65F2A8AE9D1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_4FFB95F3A004502DA4B4B65F2A8AE9D1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecurities_4FFB95F3A004502DA4B4B65F2A8AE9D1" xlink:to="lab_us-gaap_AvailableForSaleSecurities_4FFB95F3A004502DA4B4B65F2A8AE9D1" xlink:type="arc" />
    <link:label id="lab_us-gaap_TradingSecuritiesCost_58E4D5A37CC5B1A9361DB3DE021728E8_terseLabel_en-US" xlink:label="lab_us-gaap_TradingSecuritiesCost_0159C071E87A53C68AB69D80BE44561F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest-only and principal-only strips, amortized cost</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TradingSecuritiesCost" xlink:label="loc_us-gaap_TradingSecuritiesCost_0159C071E87A53C68AB69D80BE44561F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecuritiesCost_0159C071E87A53C68AB69D80BE44561F" xlink:to="lab_us-gaap_TradingSecuritiesCost_0159C071E87A53C68AB69D80BE44561F" xlink:type="arc" />
    <link:label id="lab_us-gaap_TradingSecuritiesOther_D6332A7F729A6E18A298B3DE0217AA1E_verboseLabel_en-US" xlink:label="lab_us-gaap_TradingSecuritiesOther_19B4D0D8A3F859E39575E622FD8EA39B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest-only and principal-only strips, fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TradingSecuritiesOther" xlink:label="loc_us-gaap_TradingSecuritiesOther_19B4D0D8A3F859E39575E622FD8EA39B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecuritiesOther_19B4D0D8A3F859E39575E622FD8EA39B" xlink:to="lab_us-gaap_TradingSecuritiesOther_19B4D0D8A3F859E39575E622FD8EA39B" xlink:type="arc" />
    <link:label id="lab_agnc_AgencySecuritiesAmortizedCost_84362FD2CCAA2ADE7E28B3DE0217BA92_terseLabel_en-US" xlink:label="lab_agnc_AgencySecuritiesAmortizedCost_8F234E55616452A68356E01A2BC33F43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total agency MBS, amortized cost</link:label>
    <link:label id="lab_agnc_AgencySecuritiesAmortizedCost_84362FD2CCAA2ADE7E28B3DE0217BA92_label_en-US" xlink:label="lab_agnc_AgencySecuritiesAmortizedCost_8F234E55616452A68356E01A2BC33F43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Agency Securities Amortized Cost</link:label>
    <link:label id="lab_agnc_AgencySecuritiesAmortizedCost_84362FD2CCAA2ADE7E28B3DE0217BA92_documentation_en-US" xlink:label="lab_agnc_AgencySecuritiesAmortizedCost_8F234E55616452A68356E01A2BC33F43" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents agency securities by type net of adjustments including accretion, amortization, collection of cash, previous other-than -temporary impairments recognized in earnings (less any cumulative-effect adjustments recognized, as defined), and fair value hedge accounting adjustments, if any.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AgencySecuritiesAmortizedCost" xlink:label="loc_agnc_AgencySecuritiesAmortizedCost_8F234E55616452A68356E01A2BC33F43" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AgencySecuritiesAmortizedCost_8F234E55616452A68356E01A2BC33F43" xlink:to="lab_agnc_AgencySecuritiesAmortizedCost_8F234E55616452A68356E01A2BC33F43" xlink:type="arc" />
    <link:label id="lab_agnc_TotalAgencySecurities_DAA1027267C6456EDEDBB3DE0217699B_terseLabel_en-US" xlink:label="lab_agnc_TotalAgencySecurities_CC7BA5462F3B56E486DE457E72AF17E0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total agency MBS, at fair value</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TotalAgencySecurities" xlink:label="loc_agnc_TotalAgencySecurities_CC7BA5462F3B56E486DE457E72AF17E0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TotalAgencySecurities_CC7BA5462F3B56E486DE457E72AF17E0" xlink:to="lab_agnc_TotalAgencySecurities_CC7BA5462F3B56E486DE457E72AF17E0" xlink:type="arc" />
    <link:label id="lab_us-gaap_LongMember_26E0C9156777D1186B74FCEADDC89F33_terseLabel_en-US" xlink:label="lab_us-gaap_LongMember_26E0C9156777D1186B74FCEADDC89F33" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Long [Member]</link:label>
    <link:label id="lab_us-gaap_LongMember_26E0C9156777D1186B74FCEADDC89F33_label_en-US" xlink:label="lab_us-gaap_LongMember_26E0C9156777D1186B74FCEADDC89F33" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_26E0C9156777D1186B74FCEADDC89F33" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongMember_26E0C9156777D1186B74FCEADDC89F33" xlink:to="lab_us-gaap_LongMember_26E0C9156777D1186B74FCEADDC89F33" xlink:type="arc" />
    <link:label id="lab_us-gaap_HedgingDesignationAxis_F6B72036EB5333CF1F3BFCEADDC87F84_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_F6B72036EB5333CF1F3BFCEADDC87F84" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Hedging Designation [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_F6B72036EB5333CF1F3BFCEADDC87F84" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationAxis_F6B72036EB5333CF1F3BFCEADDC87F84" xlink:to="lab_us-gaap_HedgingDesignationAxis_F6B72036EB5333CF1F3BFCEADDC87F84" xlink:type="arc" />
    <link:label id="lab_us-gaap_HedgingDesignationDomain_A897503F639673DB8D9AFCEADDC8E696_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_A897503F639673DB8D9AFCEADDC8E696" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Hedging Designation [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_A897503F639673DB8D9AFCEADDC8E696" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationDomain_A897503F639673DB8D9AFCEADDC8E696" xlink:to="lab_us-gaap_HedgingDesignationDomain_A897503F639673DB8D9AFCEADDC8E696" xlink:type="arc" />
    <link:label id="lab_us-gaap_NondesignatedMember_595D39ACA20863C97E82FCEADDC8DB3B_terseLabel_en-US" xlink:label="lab_us-gaap_NondesignatedMember_595D39ACA20863C97E82FCEADDC8DB3B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Not Designated as Hedging Instrument [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_595D39ACA20863C97E82FCEADDC8DB3B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NondesignatedMember_595D39ACA20863C97E82FCEADDC8DB3B" xlink:to="lab_us-gaap_NondesignatedMember_595D39ACA20863C97E82FCEADDC8DB3B" xlink:type="arc" />
    <link:label id="lab_agnc_OtherDerivativesMember_99F9E9E04B71F00A6343FCEADDC97C09_verboseLabel_en-US" xlink:label="lab_agnc_OtherDerivativesMember_99F9E9E04B71F00A6343FCEADDC97C09" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Other derivative instruments [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_99F9E9E04B71F00A6343FCEADDC97C09" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherDerivativesMember_99F9E9E04B71F00A6343FCEADDC97C09" xlink:to="lab_agnc_OtherDerivativesMember_99F9E9E04B71F00A6343FCEADDC97C09" xlink:type="arc" />
    <link:label id="lab_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D_terseLabel_en-US" xlink:label="lab_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Receiver Swaption [Member]</link:label>
    <link:label id="lab_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D_label_en-US" xlink:label="lab_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Receiver Swaption [Member]</link:label>
    <link:label id="lab_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D_documentation_en-US" xlink:label="lab_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Receiver Swaption [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ReceiverSwaptionMember" xlink:label="loc_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D" xlink:to="lab_agnc_ReceiverSwaptionMember_CCCF0AB189F8881BD7B7FCEADDCCFB8D" xlink:type="arc" />
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_70205E7F34972E513691FCEADDCD8065_verboseLabel_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_70205E7F34972E513691FCEADDCD8065" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_70205E7F34972E513691FCEADDCD8065" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_70205E7F34972E513691FCEADDCD8065" xlink:to="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_70205E7F34972E513691FCEADDCD8065" xlink:type="arc" />
    <link:label id="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis_9847227CBF88F4F207ADFCEADDCE5BD3_terseLabel_en-US" xlink:label="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis_9847227CBF88F4F207ADFCEADDCE5BD3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis_9847227CBF88F4F207ADFCEADDCE5BD3_label_en-US" xlink:label="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis_9847227CBF88F4F207ADFCEADDCE5BD3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_9847227CBF88F4F207ADFCEADDCE5BD3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_9847227CBF88F4F207ADFCEADDCE5BD3" xlink:to="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis_9847227CBF88F4F207ADFCEADDCE5BD3" xlink:type="arc" />
    <link:label id="lab_us-gaap_OptionIndexedToIssuersEquityTypeDomain_B26A1CB2358B8008027CFCEADDCE130F_terseLabel_en-US" xlink:label="lab_us-gaap_OptionIndexedToIssuersEquityTypeDomain_B26A1CB2358B8008027CFCEADDCE130F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Domain]</link:label>
    <link:label id="lab_us-gaap_OptionIndexedToIssuersEquityTypeDomain_B26A1CB2358B8008027CFCEADDCE130F_label_en-US" xlink:label="lab_us-gaap_OptionIndexedToIssuersEquityTypeDomain_B26A1CB2358B8008027CFCEADDCE130F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_B26A1CB2358B8008027CFCEADDCE130F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_B26A1CB2358B8008027CFCEADDCE130F" xlink:to="lab_us-gaap_OptionIndexedToIssuersEquityTypeDomain_B26A1CB2358B8008027CFCEADDCE130F" xlink:type="arc" />
    <link:label id="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D_terseLabel_en-US" xlink:label="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Changes in Derivative and Other Hedge Portfolio [Roll Forward]</link:label>
    <link:label id="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D_label_en-US" xlink:label="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Changes in Derivative and Other Hedge Portfolio [Roll Forward]</link:label>
    <link:label id="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D_documentation_en-US" xlink:label="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Changes in Derivative and Other Hedge Portfolio [Roll Forward]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:label="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D" xlink:to="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_53180DB6793A77AB882CFCEADDCEF52D" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_EFB4C81C1B8C5AD527A7FCEADDCF5A92_negatedPeriodStartLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount_EFB4C81C1B8C5AD527A7FCEADDCF5A92" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="resource" xml:lang="en-US">Notional Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_EFB4C81C1B8C5AD527A7FCEADDCF5A92" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilityNotionalAmount_EFB4C81C1B8C5AD527A7FCEADDCF5A92" xlink:to="lab_us-gaap_DerivativeLiabilityNotionalAmount_EFB4C81C1B8C5AD527A7FCEADDCF5A92" xlink:type="arc" />
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3_negatedLabel_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Additions</link:label>
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3_label_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Notional Amount Of Derivatives Not Designated As Hedging Instruments Additions During The Period</link:label>
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3_documentation_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Notional Amount Of Derivatives Not Designated As Hedging Instruments Additions During The Period</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3" xlink:to="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_90938633E4EA69ED6007FCEADDCFCAF3" xlink:type="arc" />
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB_negatedLabel_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Settlement, Expirations or Exercise</link:label>
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB_label_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Notional Amount Of Derivatives Not Designated As Hedging Instruments Settlement Expiration During The Period</link:label>
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB_documentation_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Notional Amount Of Derivatives Not Designated As Hedging Instruments Settlement Expiration During The Period</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB" xlink:to="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C0FE7212455CA3B77F52FCEADDCF20AB" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_89002969629D7F5B0259FCEADDCF3CC3_negatedPeriodEndLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount_89002969629D7F5B0259FCEADDCF3CC3" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xml:lang="en-US">Notional Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_89002969629D7F5B0259FCEADDCF3CC3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilityNotionalAmount_89002969629D7F5B0259FCEADDCF3CC3" xlink:to="lab_us-gaap_DerivativeLiabilityNotionalAmount_89002969629D7F5B0259FCEADDCF3CC3" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_6740A841393B659447EDFCEADDCFAB72_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_6740A841393B659447EDFCEADDCFAB72" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Amount Gain/(Loss) Recognized in Income on Derivatives</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_6740A841393B659447EDFCEADDCFAB72" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_6740A841393B659447EDFCEADDCFAB72" xlink:to="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_6740A841393B659447EDFCEADDCFAB72" xlink:type="arc" />
    <link:label id="lab_us-gaap_TradingSecurities_7A732A11C14E5B8BE55DFCEADDD085BB_terseLabel_en-US" xlink:label="lab_us-gaap_TradingSecurities_7A732A11C14E5B8BE55DFCEADDD085BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Trading Securities</link:label>
    <link:label id="lab_us-gaap_TradingSecurities_7A732A11C14E5B8BE55DFCEADDD085BB_label_en-US" xlink:label="lab_us-gaap_TradingSecurities_7A732A11C14E5B8BE55DFCEADDD085BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Trading Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TradingSecurities" xlink:label="loc_us-gaap_TradingSecurities_7A732A11C14E5B8BE55DFCEADDD085BB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecurities_7A732A11C14E5B8BE55DFCEADDD085BB" xlink:to="lab_us-gaap_TradingSecurities_7A732A11C14E5B8BE55DFCEADDD085BB" xlink:type="arc" />
    <link:label id="lab_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875_terseLabel_en-US" xlink:label="lab_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Trading Securities Added During the Period</link:label>
    <link:label id="lab_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875_label_en-US" xlink:label="lab_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Trading Securities Added During the Period</link:label>
    <link:label id="lab_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875_documentation_en-US" xlink:label="lab_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Trading Securities Added During the Period</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_TradingSecuritiesAddedDuringthePeriod" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875" xlink:to="lab_agnc_TradingSecuritiesAddedDuringthePeriod_04CE56689A841BEC8A73FCEADDD04875" xlink:type="arc" />
    <link:label id="lab_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E_terseLabel_en-US" xlink:label="lab_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notional Amount Of Trading Securities Settlement Expiration During The Period</link:label>
    <link:label id="lab_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E_label_en-US" xlink:label="lab_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Notional Amount Of Trading Securities Settlement Expiration During The Period</link:label>
    <link:label id="lab_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E_documentation_en-US" xlink:label="lab_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Notional Amount Of Trading Securities Settlement Expiration During The Period</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E" xlink:to="lab_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_A4F97424427613F9A7C7FCEADDD0394E" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_40AA41BE74D337606B93ADEB676E5F59_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_DD7BD39A733B5F079E754E06E5816889" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Measurements</link:label>
    <link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_40AA41BE74D337606B93ADEB676E5F59_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_DD7BD39A733B5F079E754E06E5816889" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Disclosures [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_DD7BD39A733B5F079E754E06E5816889" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresTextBlock_DD7BD39A733B5F079E754E06E5816889" xlink:to="lab_us-gaap_FairValueDisclosuresTextBlock_DD7BD39A733B5F079E754E06E5816889" xlink:type="arc" />
    <link:label id="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8_terseLabel_en-US" xlink:label="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cost and Proceeds of Investment Securities [Member]</link:label>
    <link:label id="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8_label_en-US" xlink:label="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cost and Proceeds of Investment Securities [Member]</link:label>
    <link:label id="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8_documentation_en-US" xlink:label="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Cost and Proceeds of Investment Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CostandProceedsofInvestmentSecuritiesMember" xlink:label="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8" xlink:to="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_9304526D575AD3BB9594FD08DB7F12E8" xlink:type="arc" />
    <link:label id="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849_terseLabel_en-US" xlink:label="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gross Gain &amp; Loss of Investment Securities [Member]</link:label>
    <link:label id="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849_label_en-US" xlink:label="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gross Gain &amp; Loss of Investment Securities [Member]</link:label>
    <link:label id="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849_documentation_en-US" xlink:label="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Gross Gain &amp; Loss of Investment Securities [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:label="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849" xlink:to="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_C71FC25842E1C8A659A9FD08DB80A849" xlink:type="arc" />
    <link:label id="lab_us-gaap_UnderlyingAssetClassAxis_82DA581E7AF07DF88598FD08DB814D1D_terseLabel_en-US" xlink:label="lab_us-gaap_UnderlyingAssetClassAxis_82DA581E7AF07DF88598FD08DB814D1D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Guarantor Obligations by Underlying Asset Class [Axis]</link:label>
    <link:label id="lab_us-gaap_UnderlyingAssetClassAxis_82DA581E7AF07DF88598FD08DB814D1D_label_en-US" xlink:label="lab_us-gaap_UnderlyingAssetClassAxis_82DA581E7AF07DF88598FD08DB814D1D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Underlying Asset Class [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_UnderlyingAssetClassAxis" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_82DA581E7AF07DF88598FD08DB814D1D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_82DA581E7AF07DF88598FD08DB814D1D" xlink:to="lab_us-gaap_UnderlyingAssetClassAxis_82DA581E7AF07DF88598FD08DB814D1D" xlink:type="arc" />
    <link:label id="lab_us-gaap_UnderlyingAssetClassDomain_A298E24D938F4E07A5E5FD08DB81982C_terseLabel_en-US" xlink:label="lab_us-gaap_UnderlyingAssetClassDomain_A298E24D938F4E07A5E5FD08DB81982C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Underlying Asset Class [Domain]</link:label>
    <link:label id="lab_us-gaap_UnderlyingAssetClassDomain_A298E24D938F4E07A5E5FD08DB81982C_label_en-US" xlink:label="lab_us-gaap_UnderlyingAssetClassDomain_A298E24D938F4E07A5E5FD08DB81982C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Underlying Asset Class [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_UnderlyingAssetClassDomain" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_A298E24D938F4E07A5E5FD08DB81982C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_A298E24D938F4E07A5E5FD08DB81982C" xlink:to="lab_us-gaap_UnderlyingAssetClassDomain_A298E24D938F4E07A5E5FD08DB81982C" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecuritiesAssetsMember_2C523CAEF7AF13DE71F2FD08DB82CEA6_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesAssetsMember_2C523CAEF7AF13DE71F2FD08DB82CEA6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Securities (Assets) [Member]</link:label>
    <link:label id="lab_us-gaap_SecuritiesAssetsMember_2C523CAEF7AF13DE71F2FD08DB82CEA6_label_en-US" xlink:label="lab_us-gaap_SecuritiesAssetsMember_2C523CAEF7AF13DE71F2FD08DB82CEA6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities (Assets) [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuritiesAssetsMember" xlink:label="loc_us-gaap_SecuritiesAssetsMember_2C523CAEF7AF13DE71F2FD08DB82CEA6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesAssetsMember_2C523CAEF7AF13DE71F2FD08DB82CEA6" xlink:to="lab_us-gaap_SecuritiesAssetsMember_2C523CAEF7AF13DE71F2FD08DB82CEA6" xlink:type="arc" />
    <link:label id="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E_negatedTerseLabel_en-US" xlink:label="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Agency MBS sold, at cost</link:label>
    <link:label id="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E_label_en-US" xlink:label="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cost Of Sale Of Available For Sale Secuities</link:label>
    <link:label id="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E_documentation_en-US" xlink:label="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">CostOfSaleOfAvailableForSaleSecuities</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CostOfSaleOfAvailableForSaleSecuities" xlink:label="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E" xlink:to="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_406917104F458C0EC8A8FD08DB82007E" xlink:type="arc" />
    <link:label id="lab_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A_terseLabel_en-US" xlink:label="lab_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cost of Sale of Fair Value Option Securities</link:label>
    <link:label id="lab_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A_label_en-US" xlink:label="lab_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cost of Sale of Fair Value Option Securities</link:label>
    <link:label id="lab_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A_documentation_en-US" xlink:label="lab_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Cost of Sale of Fair Value Option Securities</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CostofSaleofFairValueOptionSecurities" xlink:label="loc_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A" xlink:to="lab_agnc_CostofSaleofFairValueOptionSecurities_466CADB17D5DEC10F631FD08DB82200A" xlink:type="arc" />
    <link:label id="lab_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED_terseLabel_en-US" xlink:label="lab_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cost of Sale of Investment Securities</link:label>
    <link:label id="lab_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED_label_en-US" xlink:label="lab_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cost of Sale of Investment Securities</link:label>
    <link:label id="lab_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED_documentation_en-US" xlink:label="lab_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Cost of Sale of Investment Securities</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_CostofSaleofInvestmentSecurities" xlink:label="loc_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED" xlink:to="lab_agnc_CostofSaleofInvestmentSecurities_979BA71E9D2441B0E290FD08DB8352ED" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_7A7A9CCA88D890D1F77CFD08DB837186_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_7A7A9CCA88D890D1F77CFD08DB837186" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from agency MBS sold</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_7A7A9CCA88D890D1F77CFD08DB837186" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_7A7A9CCA88D890D1F77CFD08DB837186" xlink:to="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_7A7A9CCA88D890D1F77CFD08DB837186" xlink:type="arc" />
    <link:label id="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_FB5F90CBE8037AB1E51BFD08DB8378CA_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_FB5F90CBE8037AB1E51BFD08DB8378CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net gain (loss) on sale of investment securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_FB5F90CBE8037AB1E51BFD08DB8378CA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_FB5F90CBE8037AB1E51BFD08DB8378CA" xlink:to="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_FB5F90CBE8037AB1E51BFD08DB8378CA" xlink:type="arc" />
    <link:label id="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_85420040B0A5650E4120FD08DB8339B3_terseLabel_en-US" xlink:label="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_85420040B0A5650E4120FD08DB8339B3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gross gain on sale of investment securities</link:label>
    <link:label id="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_85420040B0A5650E4120FD08DB8339B3_label_en-US" xlink:label="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_85420040B0A5650E4120FD08DB8339B3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Marketable Securities, Realized Gain (Loss)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MarketableSecuritiesRealizedGainLoss" xlink:label="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_85420040B0A5650E4120FD08DB8339B3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_85420040B0A5650E4120FD08DB8339B3" xlink:to="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_85420040B0A5650E4120FD08DB8339B3" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_9B5E925B2C3CAE9ED216FD08DB837F53_negatedLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_9B5E925B2C3CAE9ED216FD08DB837F53" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Gross loss on sale of investment securities</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_9B5E925B2C3CAE9ED216FD08DB837F53_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_9B5E925B2C3CAE9ED216FD08DB837F53" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Gross Realized Losses</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_9B5E925B2C3CAE9ED216FD08DB837F53" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_9B5E925B2C3CAE9ED216FD08DB837F53" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_9B5E925B2C3CAE9ED216FD08DB837F53" xlink:type="arc" />
    <link:label id="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_DD82198671AE61D0B66BADEB6824107F_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_00E36220B05D51E3B6DE006C359B7B9F" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Net Unrealized Gain (Loss) on Swaps</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_00E36220B05D51E3B6DE006C359B7B9F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_00E36220B05D51E3B6DE006C359B7B9F" xlink:to="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_00E36220B05D51E3B6DE006C359B7B9F" xlink:type="arc" />
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_3AF4AED2930833958092ADEB68247BEA_terseLabel_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_BA1192C853895A4D921DB98ABF98CDE1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notional Amount Of Derivatives Not Designated As Hedging Instruments Additions During The Period</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_BA1192C853895A4D921DB98ABF98CDE1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_BA1192C853895A4D921DB98ABF98CDE1" xlink:to="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_BA1192C853895A4D921DB98ABF98CDE1" xlink:type="arc" />
    <link:label id="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_10E3ECB8434CC9DC0CA9ADEB6825576B_terseLabel_en-US" xlink:label="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C5F9FFF7B5A55FC685BC11DCDF87E359" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notional Amount Of Derivatives Not Designated As Hedging Instruments Settlement Expiration During The Period</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C5F9FFF7B5A55FC685BC11DCDF87E359" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C5F9FFF7B5A55FC685BC11DCDF87E359" xlink:to="lab_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_C5F9FFF7B5A55FC685BC11DCDF87E359" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeAverageFixedInterestRate_7EA16C036C7072470ABAADEB68252369_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAverageFixedInterestRate_7B390F56AFD45FF8865E1470E3267F4C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Average Fixed Interest Rate</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_7B390F56AFD45FF8865E1470E3267F4C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAverageFixedInterestRate_7B390F56AFD45FF8865E1470E3267F4C" xlink:to="lab_us-gaap_DerivativeAverageFixedInterestRate_7B390F56AFD45FF8865E1470E3267F4C" xlink:type="arc" />
    <link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_BB45463A44DE2DE2D6D8B3DDFDF343C8_verboseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_352D197FB4F75E12BB3C052BCECC464E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Major Types of Trading Securities and Assets [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_352D197FB4F75E12BB3C052BCECC464E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_352D197FB4F75E12BB3C052BCECC464E" xlink:to="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_352D197FB4F75E12BB3C052BCECC464E" xlink:type="arc" />
    <link:label id="lab_agnc_GreaterThanFiveYearsMember_006ED705BC957B72F5A8B3DDFDF34054_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsMember_D45D371C129A5D969E3477530B05FE2D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater Than Five Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanFiveYearsMember_006ED705BC957B72F5A8B3DDFDF34054_label_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsMember_D45D371C129A5D969E3477530B05FE2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Greater Than Five Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanFiveYearsMember_006ED705BC957B72F5A8B3DDFDF34054_documentation_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsMember_D45D371C129A5D969E3477530B05FE2D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Greater Than Five Years [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_GreaterThanFiveYearsMember" xlink:label="loc_agnc_GreaterThanFiveYearsMember_D45D371C129A5D969E3477530B05FE2D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanFiveYearsMember_D45D371C129A5D969E3477530B05FE2D" xlink:to="lab_agnc_GreaterThanFiveYearsMember_D45D371C129A5D969E3477530B05FE2D" xlink:type="arc" />
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_A2C4FCF1A5D967500C12B3DDFDF318E8_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_5A921E3DBC3252F997CEEB792F6F6D18" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_A2C4FCF1A5D967500C12B3DDFDF318E8_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_5A921E3DBC3252F997CEEB792F6F6D18" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Weighted Average Life Fair Value</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_A2C4FCF1A5D967500C12B3DDFDF318E8_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_5A921E3DBC3252F997CEEB792F6F6D18" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents the weighted average life of available-for-sale agency securities by fair value.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_5A921E3DBC3252F997CEEB792F6F6D18" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_5A921E3DBC3252F997CEEB792F6F6D18" xlink:to="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_5A921E3DBC3252F997CEEB792F6F6D18" xlink:type="arc" />
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_CDF1D66F077A6DB0BF2BB3DDFDF3C3B7_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_08FAB72B12325DF6BB6ADC693638F9FD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortized Cost</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_CDF1D66F077A6DB0BF2BB3DDFDF3C3B7_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_08FAB72B12325DF6BB6ADC693638F9FD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Weighted Average Life Amortized Cost</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_CDF1D66F077A6DB0BF2BB3DDFDF3C3B7_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_08FAB72B12325DF6BB6ADC693638F9FD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents the weighted average life of available-for-sale agency securities by amortized cost.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_08FAB72B12325DF6BB6ADC693638F9FD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_08FAB72B12325DF6BB6ADC693638F9FD" xlink:to="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_08FAB72B12325DF6BB6ADC693638F9FD" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecurities_51CE13EA4FF37AD4C3D5B3DDFDF3A424_verboseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_2CAEB6E0DAA65E708C27A8492C969CE9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities classified as available for sale, Fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_2CAEB6E0DAA65E708C27A8492C969CE9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecurities_2CAEB6E0DAA65E708C27A8492C969CE9" xlink:to="lab_us-gaap_AvailableForSaleSecurities_2CAEB6E0DAA65E708C27A8492C969CE9" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_E9B6A59A30B9E180DA9EB3DDFDF3ED4F_verboseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_80F82A0AA7BE52C0AF301821764C1F44" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities classified as available for sale, Amortized cost</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_80F82A0AA7BE52C0AF301821764C1F44" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_80F82A0AA7BE52C0AF301821764C1F44" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_80F82A0AA7BE52C0AF301821764C1F44" xlink:type="arc" />
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_1D30F5DBEAA62BBA1A15B3DDFDF397A9_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_EF033E80380D5EF4A3B04BDDFC51F68C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Coupon</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_1D30F5DBEAA62BBA1A15B3DDFDF397A9_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_EF033E80380D5EF4A3B04BDDFC51F68C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Weighted Average Life Coupon Rate</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_1D30F5DBEAA62BBA1A15B3DDFDF397A9_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_EF033E80380D5EF4A3B04BDDFC51F68C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents the weighted average life of available-for-sale agency securities by weighted average coupon rate.</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_EF033E80380D5EF4A3B04BDDFC51F68C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_EF033E80380D5EF4A3B04BDDFC51F68C" xlink:to="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_EF033E80380D5EF4A3B04BDDFC51F68C" xlink:type="arc" />
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_B20ACBBEB2AA0EDCFB69B3DDFDF36BEA_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_4B468B028CEA57F9ABA85EBEFE369714" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Yield</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_B20ACBBEB2AA0EDCFB69B3DDFDF36BEA_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_4B468B028CEA57F9ABA85EBEFE369714" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Weighted Average Life yield</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_B20ACBBEB2AA0EDCFB69B3DDFDF36BEA_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_4B468B028CEA57F9ABA85EBEFE369714" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Weighted Average Life yield</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_4B468B028CEA57F9ABA85EBEFE369714" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_4B468B028CEA57F9ABA85EBEFE369714" xlink:to="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_4B468B028CEA57F9ABA85EBEFE369714" xlink:type="arc" />
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_E3D3B1DE707A647962FAAEC62B6DC211_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_8F0B52C5AEFC53D298414F6497AF644B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Goodwill and Intangible Assets Disclosure [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_8F0B52C5AEFC53D298414F6497AF644B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_8F0B52C5AEFC53D298414F6497AF644B" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_8F0B52C5AEFC53D298414F6497AF644B" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_9666AB08F22736B10489AEC62B6DB116_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_00F45CC86AF7548CB58C480566E94499" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_9666AB08F22736B10489AEC62B6DB116_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_00F45CC86AF7548CB58C480566E94499" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_00F45CC86AF7548CB58C480566E94499" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_00F45CC86AF7548CB58C480566E94499" xlink:to="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_00F45CC86AF7548CB58C480566E94499" xlink:type="arc" />
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AE9C538CF47ED8D7F21EAEC62B6DD487_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CFB2C29DFC565F27940D61F76CEA5A6F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets by Major Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AE9C538CF47ED8D7F21EAEC62B6DD487_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CFB2C29DFC565F27940D61F76CEA5A6F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets by Major Class [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CFB2C29DFC565F27940D61F76CEA5A6F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CFB2C29DFC565F27940D61F76CEA5A6F" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CFB2C29DFC565F27940D61F76CEA5A6F" xlink:type="arc" />
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8248B4288F4DE2EF9D2AAEC62B6D9C3D_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_88919CB715FC553CBBC26B905E8931F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8248B4288F4DE2EF9D2AAEC62B6D9C3D_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_88919CB715FC553CBBC26B905E8931F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_88919CB715FC553CBBC26B905E8931F4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_88919CB715FC553CBBC26B905E8931F4" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_88919CB715FC553CBBC26B905E8931F4" xlink:type="arc" />
    <link:label id="lab_us-gaap_ConsolidationItemsAxis_AF2577C6B3C47175065FAEC62B6D65F8_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_6A902B2AB443522E9BA4E99A1FC9728B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Consolidation Items [Axis]</link:label>
    <link:label id="lab_us-gaap_ConsolidationItemsAxis_AF2577C6B3C47175065FAEC62B6D65F8_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_6A902B2AB443522E9BA4E99A1FC9728B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Consolidation Items [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_6A902B2AB443522E9BA4E99A1FC9728B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsAxis_6A902B2AB443522E9BA4E99A1FC9728B" xlink:to="lab_us-gaap_ConsolidationItemsAxis_6A902B2AB443522E9BA4E99A1FC9728B" xlink:type="arc" />
    <link:label id="lab_us-gaap_ConsolidationItemsDomain_9C5CA7D3932DBC65B009AEC62B6D52C0_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_27E271F212685D42BDC046F6FF9D3BC8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Consolidation Items [Domain]</link:label>
    <link:label id="lab_us-gaap_ConsolidationItemsDomain_9C5CA7D3932DBC65B009AEC62B6D52C0_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_27E271F212685D42BDC046F6FF9D3BC8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Consolidation Items [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_27E271F212685D42BDC046F6FF9D3BC8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsDomain_27E271F212685D42BDC046F6FF9D3BC8" xlink:to="lab_us-gaap_ConsolidationItemsDomain_27E271F212685D42BDC046F6FF9D3BC8" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_BC8B4B243140389F3AFEAEC62B6DD7E1_terseLabel_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_B67F990DEB9950DCA19AC474ACBEE277" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Segments [Axis]</link:label>
    <link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_BC8B4B243140389F3AFEAEC62B6DD7E1_label_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_B67F990DEB9950DCA19AC474ACBEE277" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Segments [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_B67F990DEB9950DCA19AC474ACBEE277" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_B67F990DEB9950DCA19AC474ACBEE277" xlink:to="lab_us-gaap_StatementBusinessSegmentsAxis_B67F990DEB9950DCA19AC474ACBEE277" xlink:type="arc" />
    <link:label id="lab_us-gaap_SegmentDomain_175191504D7047A129B5AEC62B6D5F0B_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentDomain_B339B9CC2BD65C89B7D462B434B96E1C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Segments [Domain]</link:label>
    <link:label id="lab_us-gaap_SegmentDomain_175191504D7047A129B5AEC62B6D5F0B_label_en-US" xlink:label="lab_us-gaap_SegmentDomain_B339B9CC2BD65C89B7D462B434B96E1C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Segments [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_B339B9CC2BD65C89B7D462B434B96E1C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentDomain_B339B9CC2BD65C89B7D462B434B96E1C" xlink:to="lab_us-gaap_SegmentDomain_B339B9CC2BD65C89B7D462B434B96E1C" xlink:type="arc" />
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_CC22AE25A1CDA28238EAAEC62B6E76A7_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_5211CAE62CC25FCDA1ACF746C1056489" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets [Line Items]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_CC22AE25A1CDA28238EAAEC62B6E76A7_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_5211CAE62CC25FCDA1ACF746C1056489" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_5211CAE62CC25FCDA1ACF746C1056489" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_5211CAE62CC25FCDA1ACF746C1056489" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_5211CAE62CC25FCDA1ACF746C1056489" xlink:type="arc" />
    <link:label id="lab_us-gaap_Goodwill_D893F5E515CFD5F1901BAEE0B330D26D_terseLabel_en-US" xlink:label="lab_us-gaap_Goodwill_22321C43F24B50DE8D43D99B8A535722" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Goodwill</link:label>
    <link:label id="lab_us-gaap_Goodwill_D893F5E515CFD5F1901BAEE0B330D26D_label_en-US" xlink:label="lab_us-gaap_Goodwill_22321C43F24B50DE8D43D99B8A535722" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Goodwill</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_22321C43F24B50DE8D43D99B8A535722" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_22321C43F24B50DE8D43D99B8A535722" xlink:to="lab_us-gaap_Goodwill_22321C43F24B50DE8D43D99B8A535722" xlink:type="arc" />
    <link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_42B9042359AE53286BB2AEE0D88EE64C_terseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_49257496826A5E78BBB8AA96EA0A0B40" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Intangible Assets, Net (Excluding Goodwill)</link:label>
    <link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_42B9042359AE53286BB2AEE0D88EE64C_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_49257496826A5E78BBB8AA96EA0A0B40" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Intangible Assets, Net (Excluding Goodwill)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_49257496826A5E78BBB8AA96EA0A0B40" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_49257496826A5E78BBB8AA96EA0A0B40" xlink:to="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_49257496826A5E78BBB8AA96EA0A0B40" xlink:type="arc" />
    <link:label id="lab_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C0A54DDEF390D25C7B9C3ADC6E2027B6_label_en-US" xlink:label="lab_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_227D79D7B7075AFC99B75E4B6FA7DD1B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Quarterly Financial Information Disclosure [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_227D79D7B7075AFC99B75E4B6FA7DD1B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_227D79D7B7075AFC99B75E4B6FA7DD1B" xlink:to="lab_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_227D79D7B7075AFC99B75E4B6FA7DD1B" xlink:type="arc" />
    <link:label id="lab_us-gaap_QuarterlyFinancialInformationTextBlock_523A1988B2B3697732CF3ADC6E204B72_terseLabel_en-US" xlink:label="lab_us-gaap_QuarterlyFinancialInformationTextBlock_903D53B9033E558490053AD2F2753496" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Quarterly Financial Information [Text Block]</link:label>
    <link:label id="lab_us-gaap_QuarterlyFinancialInformationTextBlock_523A1988B2B3697732CF3ADC6E204B72_label_en-US" xlink:label="lab_us-gaap_QuarterlyFinancialInformationTextBlock_903D53B9033E558490053AD2F2753496" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Quarterly Financial Information [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_903D53B9033E558490053AD2F2753496" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_QuarterlyFinancialInformationTextBlock_903D53B9033E558490053AD2F2753496" xlink:to="lab_us-gaap_QuarterlyFinancialInformationTextBlock_903D53B9033E558490053AD2F2753496" xlink:type="arc" />
    <link:label id="lab_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_6A04C962E1EF4C3E338E3ADC6E20C0DF_terseLabel_en-US" xlink:label="lab_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_63042054E0355E44BCA3BEBED4353B95" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unaudited Interim Consolidated Financial Statements</link:label>
    <link:label id="lab_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_6A04C962E1EF4C3E338E3ADC6E20C0DF_label_en-US" xlink:label="lab_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_63042054E0355E44BCA3BEBED4353B95" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Disclosure of Compensation Related Costs, Share-based Payments [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_63042054E0355E44BCA3BEBED4353B95" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_63042054E0355E44BCA3BEBED4353B95" xlink:to="lab_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_63042054E0355E44BCA3BEBED4353B95" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_7A9C54FF377BDF941F2122B459800B30_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_D261ED356511543E8B32BBBA785A0B0D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Measurement Frequency [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_D261ED356511543E8B32BBBA785A0B0D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_D261ED356511543E8B32BBBA785A0B0D" xlink:to="lab_us-gaap_FairValueByMeasurementFrequencyAxis_D261ED356511543E8B32BBBA785A0B0D" xlink:type="arc" />
    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_10A97A4FBE2C35A7804722B45981B006_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F2A73DE0808153DAAB0BD4444AD03B0F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F2A73DE0808153DAAB0BD4444AD03B0F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F2A73DE0808153DAAB0BD4444AD03B0F" xlink:to="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F2A73DE0808153DAAB0BD4444AD03B0F" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_24DE178D2D7CE588CDB222B45981D32A_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_F7611E29196D5F259749F0E92A6860D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative asset, fair value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_F7611E29196D5F259749F0E92A6860D9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_F7611E29196D5F259749F0E92A6860D9" xlink:to="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_F7611E29196D5F259749F0E92A6860D9" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_7C5AB7430AE79DEE388622B4598197E2_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_4A875CC08724546DA252D2E0E56AE3CC" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Derivative liability, fair value</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_7C5AB7430AE79DEE388622B4598197E2_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_4A875CC08724546DA252D2E0E56AE3CC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments Not Designated as Hedging Instruments, Liability, at Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_4A875CC08724546DA252D2E0E56AE3CC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_4A875CC08724546DA252D2E0E56AE3CC" xlink:to="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_4A875CC08724546DA252D2E0E56AE3CC" xlink:type="arc" />
    <link:label id="lab_us-gaap_DerivativeLiabilities_D67E4E4F5624AB45C9F022B4598186E9_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_342997DA90FA50D8957AA3C9D87A4398" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Derivative Liability</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_342997DA90FA50D8957AA3C9D87A4398" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilities_342997DA90FA50D8957AA3C9D87A4398" xlink:to="lab_us-gaap_DerivativeLiabilities_342997DA90FA50D8957AA3C9D87A4398" xlink:type="arc" />
    <link:label id="lab_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_972D4AF1813505FCAC0922B45981B2D0_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_DB525C3847485644AB1EEA2D0CC2F7A5" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">U.S. Treasury Securities - short</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_972D4AF1813505FCAC0922B45981B2D0_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_DB525C3847485644AB1EEA2D0CC2F7A5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instruments Sold, Not yet Purchased, US Government and Agency Obligations</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations" xlink:label="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_DB525C3847485644AB1EEA2D0CC2F7A5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_DB525C3847485644AB1EEA2D0CC2F7A5" xlink:to="lab_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_DB525C3847485644AB1EEA2D0CC2F7A5" xlink:type="arc" />
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_E1D7F91F75390E26BE4022B4598184A8_verboseLabel_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet_5006A15923C150D7AA23FF2D76E04AE3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Total - (short)/long, net</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Governmentbondsownedandsoldshortnet" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_5006A15923C150D7AA23FF2D76E04AE3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Governmentbondsownedandsoldshortnet_5006A15923C150D7AA23FF2D76E04AE3" xlink:to="lab_agnc_Governmentbondsownedandsoldshortnet_5006A15923C150D7AA23FF2D76E04AE3" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2110297C40EC1AD7A93EB3F7F68CAD37_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_C8C483467AA653C1AD8B50D772BE1B6E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss) [Member]</link:label>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2110297C40EC1AD7A93EB3F7F68CAD37_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_C8C483467AA653C1AD8B50D772BE1B6E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">AOCI Attributable to Parent [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_C8C483467AA653C1AD8B50D772BE1B6E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_C8C483467AA653C1AD8B50D772BE1B6E" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_C8C483467AA653C1AD8B50D772BE1B6E" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_569D279DBC2DD527DC52B3F7F68C545A_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_89CD6D6589AD536BBED0B3C5A0965DEC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unrealized Loss Position For - Estimated Fair Value - Less than 12 Months</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_569D279DBC2DD527DC52B3F7F68C545A_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_89CD6D6589AD536BBED0B3C5A0965DEC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Continuous Unrealized Loss Position, Less than Twelve Months, Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_89CD6D6589AD536BBED0B3C5A0965DEC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_89CD6D6589AD536BBED0B3C5A0965DEC" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_89CD6D6589AD536BBED0B3C5A0965DEC" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_8B9A2BE4673F4EABB32AB3F7F68C8B58_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_5FEF2295CC5E52C2A02DA1E8DC553C5F" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Unrealized Loss Position For - Unrealized Loss - Less than 12 Months</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_8B9A2BE4673F4EABB32AB3F7F68C8B58_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_5FEF2295CC5E52C2A02DA1E8DC553C5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Continuous Unrealized Loss Position, Less than 12 Months, Aggregate Loss</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_5FEF2295CC5E52C2A02DA1E8DC553C5F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_5FEF2295CC5E52C2A02DA1E8DC553C5F" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_5FEF2295CC5E52C2A02DA1E8DC553C5F" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_2BBE186103DA54BAF3F8B3F7F68D3515_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_2B3473BE11B056C6B9351DF334265D00" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unrealized Loss Position For - Estimated Fair Value - 12 Months or More</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_2BBE186103DA54BAF3F8B3F7F68D3515_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_2B3473BE11B056C6B9351DF334265D00" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Continuous Unrealized Loss Position, Twelve Months or Longer, Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_2B3473BE11B056C6B9351DF334265D00" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_2B3473BE11B056C6B9351DF334265D00" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_2B3473BE11B056C6B9351DF334265D00" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_E185E7910E392CB31FA2B3F7F69250F4_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_95672AC214C0562B870ED1C747AD37B8" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Unrealized Loss Position For - Unrealized Loss - 12 Months or More</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_E185E7910E392CB31FA2B3F7F69250F4_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_95672AC214C0562B870ED1C747AD37B8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Continuous Unrealized Loss Position, 12 Months or Longer, Aggregate Loss</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_95672AC214C0562B870ED1C747AD37B8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_95672AC214C0562B870ED1C747AD37B8" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_95672AC214C0562B870ED1C747AD37B8" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_DE42601CCFEE731AA08EB3F7F6929740_totalLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_A5DABC66F7D85CE2980719747AC60A24" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Unrealized Loss Position For - Estimated Fair Value - Total</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_DE42601CCFEE731AA08EB3F7F6929740_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_A5DABC66F7D85CE2980719747AC60A24" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_A5DABC66F7D85CE2980719747AC60A24" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_A5DABC66F7D85CE2980719747AC60A24" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_A5DABC66F7D85CE2980719747AC60A24" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_752E80632A2D8691B80CB3F7F6925727_negatedTotalLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_DF5FF983A986597580DB931E40BCAC50" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="resource" xml:lang="en-US">Unrealized Loss Position For - Unrealized Loss - Total</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_752E80632A2D8691B80CB3F7F6925727_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_DF5FF983A986597580DB931E40BCAC50" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Continuous Unrealized Loss Position, Aggregate Loss</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_DF5FF983A986597580DB931E40BCAC50" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_DF5FF983A986597580DB931E40BCAC50" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_DF5FF983A986597580DB931E40BCAC50" xlink:type="arc" />
    <link:label id="lab_us-gaap_VariableRateAxis_2200516FCB91226A440A22C06A6DB69D_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateAxis_BFFE2300FE1F50DBB9E144468F1F7424" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Variable Rate [Axis]</link:label>
    <link:label id="lab_us-gaap_VariableRateAxis_2200516FCB91226A440A22C06A6DB69D_label_en-US" xlink:label="lab_us-gaap_VariableRateAxis_BFFE2300FE1F50DBB9E144468F1F7424" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Variable Rate [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_BFFE2300FE1F50DBB9E144468F1F7424" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableRateAxis_BFFE2300FE1F50DBB9E144468F1F7424" xlink:to="lab_us-gaap_VariableRateAxis_BFFE2300FE1F50DBB9E144468F1F7424" xlink:type="arc" />
    <link:label id="lab_us-gaap_VariableRateDomain_5E4CC40CA793BD5B308222C06A6DE46D_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateDomain_5571F899C89A5B5DABBDB118E8DC8129" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Variable Rate [Domain]</link:label>
    <link:label id="lab_us-gaap_VariableRateDomain_5E4CC40CA793BD5B308222C06A6DE46D_label_en-US" xlink:label="lab_us-gaap_VariableRateDomain_5571F899C89A5B5DABBDB118E8DC8129" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Variable Rate [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_5571F899C89A5B5DABBDB118E8DC8129" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableRateDomain_5571F899C89A5B5DABBDB118E8DC8129" xlink:to="lab_us-gaap_VariableRateDomain_5571F899C89A5B5DABBDB118E8DC8129" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredUnitsByNameAxis_048827AFA09F97963E5722C06A6D8879_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredUnitsByNameAxis_3DEAD6F8465F5103A12F7B8F42DF5077" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Units by Name [Axis]</link:label>
    <link:label id="lab_us-gaap_PreferredUnitsByNameAxis_048827AFA09F97963E5722C06A6D8879_label_en-US" xlink:label="lab_us-gaap_PreferredUnitsByNameAxis_3DEAD6F8465F5103A12F7B8F42DF5077" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Units by Name [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis_3DEAD6F8465F5103A12F7B8F42DF5077" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis_3DEAD6F8465F5103A12F7B8F42DF5077" xlink:to="lab_us-gaap_PreferredUnitsByNameAxis_3DEAD6F8465F5103A12F7B8F42DF5077" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredUnitsClassDomain_304DE3B2AF868011A6FB22C06A6DC435_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredUnitsClassDomain_2D4B66E3CA43530C81D103B1690F2D2C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Units, Class [Domain]</link:label>
    <link:label id="lab_us-gaap_PreferredUnitsClassDomain_304DE3B2AF868011A6FB22C06A6DC435_label_en-US" xlink:label="lab_us-gaap_PreferredUnitsClassDomain_2D4B66E3CA43530C81D103B1690F2D2C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Units, Class [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="loc_us-gaap_PreferredUnitsClassDomain_2D4B66E3CA43530C81D103B1690F2D2C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredUnitsClassDomain_2D4B66E3CA43530C81D103B1690F2D2C" xlink:to="lab_us-gaap_PreferredUnitsClassDomain_2D4B66E3CA43530C81D103B1690F2D2C" xlink:type="arc" />
    <link:label id="lab_agnc_DepositaryShareMember_274B9416F6AC4D9D6C2122C06A6D1EAB_terseLabel_en-US" xlink:label="lab_agnc_DepositaryShareMember_B2875840758F5ABF83F50D40A850513B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Depositary Share [Member]</link:label>
    <link:label id="lab_agnc_DepositaryShareMember_274B9416F6AC4D9D6C2122C06A6D1EAB_label_en-US" xlink:label="lab_agnc_DepositaryShareMember_B2875840758F5ABF83F50D40A850513B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Depositary Share [Member]</link:label>
    <link:label id="lab_agnc_DepositaryShareMember_274B9416F6AC4D9D6C2122C06A6D1EAB_documentation_en-US" xlink:label="lab_agnc_DepositaryShareMember_B2875840758F5ABF83F50D40A850513B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Depositary Share [Member]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_DepositaryShareMember" xlink:label="loc_agnc_DepositaryShareMember_B2875840758F5ABF83F50D40A850513B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DepositaryShareMember_B2875840758F5ABF83F50D40A850513B" xlink:to="lab_agnc_DepositaryShareMember_B2875840758F5ABF83F50D40A850513B" xlink:type="arc" />
    <link:label id="lab_us-gaap_SeriesBPreferredStockMember_49C65D83893AD0307E2822C06A6E696F_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesBPreferredStockMember_BA02913033895151A1FB66E19EA8BFF5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Series B Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_SeriesBPreferredStockMember_49C65D83893AD0307E2822C06A6E696F_label_en-US" xlink:label="lab_us-gaap_SeriesBPreferredStockMember_BA02913033895151A1FB66E19EA8BFF5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Series B Preferred Stock [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_BA02913033895151A1FB66E19EA8BFF5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesBPreferredStockMember_BA02913033895151A1FB66E19EA8BFF5" xlink:to="lab_us-gaap_SeriesBPreferredStockMember_BA02913033895151A1FB66E19EA8BFF5" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockPercentInterestPerShare_A97A4AE0FE0B981D439A22C06A6E7AC1_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockPercentInterestPerShare_516F41D3BA0B50D6A02A7A51FA05FFA7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Percent Interest Per Share</link:label>
    <link:label id="lab_agnc_PreferredStockPercentInterestPerShare_A97A4AE0FE0B981D439A22C06A6E7AC1_label_en-US" xlink:label="lab_agnc_PreferredStockPercentInterestPerShare_516F41D3BA0B50D6A02A7A51FA05FFA7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock, Percent Interest Per Share</link:label>
    <link:label id="lab_agnc_PreferredStockPercentInterestPerShare_A97A4AE0FE0B981D439A22C06A6E7AC1_documentation_en-US" xlink:label="lab_agnc_PreferredStockPercentInterestPerShare_516F41D3BA0B50D6A02A7A51FA05FFA7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Preferred Stock, Percent Interest Per Share</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PreferredStockPercentInterestPerShare" xlink:label="loc_agnc_PreferredStockPercentInterestPerShare_516F41D3BA0B50D6A02A7A51FA05FFA7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockPercentInterestPerShare_516F41D3BA0B50D6A02A7A51FA05FFA7" xlink:to="lab_agnc_PreferredStockPercentInterestPerShare_516F41D3BA0B50D6A02A7A51FA05FFA7" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_61EC5BD229B7E1E8429B22C06A6E6A1F_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_E6ABBFB1BC115928BF490F403A569094" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Capital Shares Reserved for Future Issuance</link:label>
    <link:label id="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_61EC5BD229B7E1E8429B22C06A6E6A1F_label_en-US" xlink:label="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_E6ABBFB1BC115928BF490F403A569094" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock, Capital Shares Reserved for Future Issuance</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_E6ABBFB1BC115928BF490F403A569094" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_E6ABBFB1BC115928BF490F403A569094" xlink:to="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_E6ABBFB1BC115928BF490F403A569094" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockDividendRatePercentage_79FC27773F74233AF9EA22C06A6E2B06_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePercentage_51D821CC586F503A9796FADBE0BC24FF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Dividend Rate, Percentage</link:label>
    <link:label id="lab_us-gaap_PreferredStockDividendRatePercentage_79FC27773F74233AF9EA22C06A6E2B06_label_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePercentage_51D821CC586F503A9796FADBE0BC24FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock, Dividend Rate, Percentage</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_51D821CC586F503A9796FADBE0BC24FF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendRatePercentage_51D821CC586F503A9796FADBE0BC24FF" xlink:to="lab_us-gaap_PreferredStockDividendRatePercentage_51D821CC586F503A9796FADBE0BC24FF" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockLiquidationPreference_EC918296CC5B05D8332D22C06A6E781C_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockLiquidationPreference_0224B7E08C0F55FAA362CC877A9E2278" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Liquidation Preference Per Share</link:label>
    <link:label id="lab_us-gaap_PreferredStockLiquidationPreference_EC918296CC5B05D8332D22C06A6E781C_label_en-US" xlink:label="lab_us-gaap_PreferredStockLiquidationPreference_0224B7E08C0F55FAA362CC877A9E2278" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock, Liquidation Preference Per Share</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockLiquidationPreference" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_0224B7E08C0F55FAA362CC877A9E2278" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockLiquidationPreference_0224B7E08C0F55FAA362CC877A9E2278" xlink:to="lab_us-gaap_PreferredStockLiquidationPreference_0224B7E08C0F55FAA362CC877A9E2278" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockAuthorizedButNotIssued_901F69668E92B98FC76022C06A6E48C1_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockAuthorizedButNotIssued_7AC14BA2B08E58F88AAD0659F4C4B19F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock Authorized, but not Issued</link:label>
    <link:label id="lab_agnc_PreferredStockAuthorizedButNotIssued_901F69668E92B98FC76022C06A6E48C1_label_en-US" xlink:label="lab_agnc_PreferredStockAuthorizedButNotIssued_7AC14BA2B08E58F88AAD0659F4C4B19F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock Authorized, but not Issued</link:label>
    <link:label id="lab_agnc_PreferredStockAuthorizedButNotIssued_901F69668E92B98FC76022C06A6E48C1_documentation_en-US" xlink:label="lab_agnc_PreferredStockAuthorizedButNotIssued_7AC14BA2B08E58F88AAD0659F4C4B19F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Preferred Stock Authorized, but not Issued</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_PreferredStockAuthorizedButNotIssued" xlink:label="loc_agnc_PreferredStockAuthorizedButNotIssued_7AC14BA2B08E58F88AAD0659F4C4B19F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockAuthorizedButNotIssued_7AC14BA2B08E58F88AAD0659F4C4B19F" xlink:to="lab_agnc_PreferredStockAuthorizedButNotIssued_7AC14BA2B08E58F88AAD0659F4C4B19F" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_F2A4486993E5C23B9D0F22C06A6EDF1F_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_C5B09F3E56BA50148E543028D60561A1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from Issuance of Redeemable Preferred Stock</link:label>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_F2A4486993E5C23B9D0F22C06A6EDF1F_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_C5B09F3E56BA50148E543028D60561A1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Issuance of Redeemable Preferred Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_C5B09F3E56BA50148E543028D60561A1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_C5B09F3E56BA50148E543028D60561A1" xlink:to="lab_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_C5B09F3E56BA50148E543028D60561A1" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_21ACDF888CE2C217DD4522C06A6EBF52_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_7314CAE37F7D5B5B872A37D527A80479" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Payments for Repurchase of Redeemable Preferred Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_7314CAE37F7D5B5B872A37D527A80479" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_7314CAE37F7D5B5B872A37D527A80479" xlink:to="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_7314CAE37F7D5B5B872A37D527A80479" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_992004CD469225D83B1822B3A08F2239_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1FDD41A76F6C59358C31E115AF6A023D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates</link:label>
    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_992004CD469225D83B1822B3A08F2239_label_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1FDD41A76F6C59358C31E115AF6A023D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_992004CD469225D83B1822B3A08F2239_documentation_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1FDD41A76F6C59358C31E115AF6A023D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1FDD41A76F6C59358C31E115AF6A023D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1FDD41A76F6C59358C31E115AF6A023D" xlink:to="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_1FDD41A76F6C59358C31E115AF6A023D" xlink:type="arc" />
    <link:label id="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_DADD08707453605E094D22B3A08F96EA_terseLabel_en-US" xlink:label="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_84A6911BA00753A098948D7B1E0BB8C8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Federal Home Loan Bank Advances and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_DADD08707453605E094D22B3A08F96EA_label_en-US" xlink:label="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_84A6911BA00753A098948D7B1E0BB8C8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Federal Home Loan Bank Advances and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_DADD08707453605E094D22B3A08F96EA_documentation_en-US" xlink:label="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_84A6911BA00753A098948D7B1E0BB8C8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Schedule of Federal Home Loan Bank Advances and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_84A6911BA00753A098948D7B1E0BB8C8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_84A6911BA00753A098948D7B1E0BB8C8" xlink:to="lab_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_84A6911BA00753A098948D7B1E0BB8C8" xlink:type="arc" />
    <link:label id="lab_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_D750EE8CB111486FA487ADEB6701F74E_verboseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_5A7EDF10B7E15FB888F3BE876F392B0F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements And Other Debt</link:label>
    <link:label id="lab_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_D750EE8CB111486FA487ADEB6701F74E_label_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_5A7EDF10B7E15FB888F3BE876F392B0F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements, Resale Agreements, Securities Borrowed, and Securities Loaned Disclosure [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock" xlink:label="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_5A7EDF10B7E15FB888F3BE876F392B0F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_5A7EDF10B7E15FB888F3BE876F392B0F" xlink:to="lab_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_5A7EDF10B7E15FB888F3BE876F392B0F" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementOfStockholdersEquityAbstract_6087625B9C43D7BB2A510F89D0C097B8_label_en-US" xlink:label="lab_us-gaap_StatementOfStockholdersEquityAbstract_6087625B9C43D7BB2A510F89D0C097B8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement of Stockholders' Equity [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_6087625B9C43D7BB2A510F89D0C097B8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_6087625B9C43D7BB2A510F89D0C097B8" xlink:to="lab_us-gaap_StatementOfStockholdersEquityAbstract_6087625B9C43D7BB2A510F89D0C097B8" xlink:type="arc" />
    <link:label id="lab_us-gaap_StatementEquityComponentsAxis_4DF9E4A89951CA0BEB210F89D0C8A34E_verboseLabel_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_4DF9E4A89951CA0BEB210F89D0C8A34E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Statement, Equity Components [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_4DF9E4A89951CA0BEB210F89D0C8A34E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4DF9E4A89951CA0BEB210F89D0C8A34E" xlink:to="lab_us-gaap_StatementEquityComponentsAxis_4DF9E4A89951CA0BEB210F89D0C8A34E" xlink:type="arc" />
    <link:label id="lab_us-gaap_PreferredStockMember_09A882A3E8BC1AC125180F89D0C9A08D_label_en-US" xlink:label="lab_us-gaap_PreferredStockMember_09A882A3E8BC1AC125180F89D0C9A08D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_09A882A3E8BC1AC125180F89D0C9A08D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockMember_09A882A3E8BC1AC125180F89D0C9A08D" xlink:to="lab_us-gaap_PreferredStockMember_09A882A3E8BC1AC125180F89D0C9A08D" xlink:type="arc" />
    <link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_911EF1BCB0F25310845A0F89D0C98F43_terseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember_911EF1BCB0F25310845A0F89D0C98F43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Additional Paid-in Capital [Member]</link:label>
    <link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_911EF1BCB0F25310845A0F89D0C98F43_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember_911EF1BCB0F25310845A0F89D0C98F43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Additional Paid-in Capital [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_911EF1BCB0F25310845A0F89D0C98F43" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapitalMember_911EF1BCB0F25310845A0F89D0C98F43" xlink:to="lab_us-gaap_AdditionalPaidInCapitalMember_911EF1BCB0F25310845A0F89D0C98F43" xlink:type="arc" />
    <link:label id="lab_us-gaap_RetainedEarningsMember_D85E5459AF3EB66138BD0F89D0C9A7C7_terseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsMember_D85E5459AF3EB66138BD0F89D0C9A7C7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Retained Earnings (Accumulated Deficit) [Member]</link:label>
    <link:label id="lab_us-gaap_RetainedEarningsMember_D85E5459AF3EB66138BD0F89D0C9A7C7_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsMember_D85E5459AF3EB66138BD0F89D0C9A7C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Retained Earnings [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_D85E5459AF3EB66138BD0F89D0C9A7C7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RetainedEarningsMember_D85E5459AF3EB66138BD0F89D0C9A7C7" xlink:to="lab_us-gaap_RetainedEarningsMember_D85E5459AF3EB66138BD0F89D0C9A7C7" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockholdersEquity_C5CC2965F65096EFCF000F89D0CA6250_periodStartLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_C5CC2965F65096EFCF000F89D0CA6250" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance, value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_C5CC2965F65096EFCF000F89D0CA6250" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity_C5CC2965F65096EFCF000F89D0CA6250" xlink:to="lab_us-gaap_StockholdersEquity_C5CC2965F65096EFCF000F89D0CA6250" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockSharesOutstanding_16983968B9C85B11039E0F89D0CA4773_periodStartLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesOutstanding_16983968B9C85B11039E0F89D0CA4773" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance, Common Stock, shares</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_16983968B9C85B11039E0F89D0CA4773" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesOutstanding_16983968B9C85B11039E0F89D0CA4773" xlink:to="lab_us-gaap_CommonStockSharesOutstanding_16983968B9C85B11039E0F89D0CA4773" xlink:type="arc" />
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_3F32E727B03870CA78A60F89D0CCB1FB_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_3F32E727B03870CA78A60F89D0CCB1FB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Adjustments to Additional Paid in Capital, Share-based Compensation and Exercise of Stock Options</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_3F32E727B03870CA78A60F89D0CCB1FB_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_3F32E727B03870CA78A60F89D0CCB1FB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Adjustments to Additional Paid in Capital, Share-based Compensation and Exercise of Stock Options</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_3F32E727B03870CA78A60F89D0CCB1FB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_3F32E727B03870CA78A60F89D0CCB1FB" xlink:to="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_3F32E727B03870CA78A60F89D0CCB1FB" xlink:type="arc" />
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_D3D9FFF5C7451672419A0F89D0CC3F84_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_D3D9FFF5C7451672419A0F89D0CC3F84" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from Issuance of Preferred Stock and Preference Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_D3D9FFF5C7451672419A0F89D0CC3F84" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_D3D9FFF5C7451672419A0F89D0CC3F84" xlink:to="lab_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_D3D9FFF5C7451672419A0F89D0CC3F84" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_DE71AEB895DC6747EE8D0F89D0CC65D0_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_DE71AEB895DC6747EE8D0F89D0CC65D0" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Redemption Amount</link:label>
    <link:label id="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_DE71AEB895DC6747EE8D0F89D0CC65D0_label_en-US" xlink:label="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_DE71AEB895DC6747EE8D0F89D0CC65D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stock Redeemed or Called During Period, Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_DE71AEB895DC6747EE8D0F89D0CC65D0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_DE71AEB895DC6747EE8D0F89D0CC65D0" xlink:to="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_DE71AEB895DC6747EE8D0F89D0CC65D0" xlink:type="arc" />
    <link:label id="lab_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269_negatedTerseLabel_en-US" xlink:label="lab_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Issuance costs of redeemed preferred stock</link:label>
    <link:label id="lab_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269_label_en-US" xlink:label="lab_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Issuance costs of redeemed preferred stock</link:label>
    <link:label id="lab_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269_documentation_en-US" xlink:label="lab_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Costs associated with the issuance of redeemed preferred stock</link:label>
    <link:loc xlink:href="agnc-20180331.xsd#agnc_Issuancecostsofredeemedpreferredstock" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269" xlink:to="lab_agnc_Issuancecostsofredeemedpreferredstock_FD82F9467A2FA32132A70F89D0CC0269" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodValue_3832908812FE16C44BA50F89D0CD34EA_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodValue_3832908812FE16C44BA50F89D0CD34EA" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Repurchase of common stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_3832908812FE16C44BA50F89D0CD34EA" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchasedDuringPeriodValue_3832908812FE16C44BA50F89D0CD34EA" xlink:to="lab_us-gaap_StockRepurchasedDuringPeriodValue_3832908812FE16C44BA50F89D0CD34EA" xlink:type="arc" />
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_C606AD8984747ED35EE90F89D0CD2144_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_C606AD8984747ED35EE90F89D0CD2144" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Payments for Repurchase of Common Stock</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_C606AD8984747ED35EE90F89D0CD2144" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_C606AD8984747ED35EE90F89D0CD2144" xlink:to="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_C606AD8984747ED35EE90F89D0CD2144" xlink:type="arc" />
    <link:label id="lab_us-gaap_DividendsPreferredStockCash_ABAAD5FB6D1D87C143500F89D0CE41C8_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DividendsPreferredStockCash_ABAAD5FB6D1D87C143500F89D0CE41C8" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Preferred dividends declared</link:label>
    <link:label id="lab_us-gaap_DividendsPreferredStockCash_ABAAD5FB6D1D87C143500F89D0CE41C8_label_en-US" xlink:label="lab_us-gaap_DividendsPreferredStockCash_ABAAD5FB6D1D87C143500F89D0CE41C8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends, Preferred Stock, Cash</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="loc_us-gaap_DividendsPreferredStockCash_ABAAD5FB6D1D87C143500F89D0CE41C8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsPreferredStockCash_ABAAD5FB6D1D87C143500F89D0CE41C8" xlink:to="lab_us-gaap_DividendsPreferredStockCash_ABAAD5FB6D1D87C143500F89D0CE41C8" xlink:type="arc" />
    <link:label id="lab_us-gaap_DividendsCommonStockCash_026C07B5321352B378C60F89D0D1AE92_negatedLabel_en-US" xlink:label="lab_us-gaap_DividendsCommonStockCash_026C07B5321352B378C60F89D0D1AE92" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Common dividends declared</link:label>
    <link:label id="lab_us-gaap_DividendsCommonStockCash_026C07B5321352B378C60F89D0D1AE92_label_en-US" xlink:label="lab_us-gaap_DividendsCommonStockCash_026C07B5321352B378C60F89D0D1AE92" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends, Common Stock, Cash</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DividendsCommonStockCash" xlink:label="loc_us-gaap_DividendsCommonStockCash_026C07B5321352B378C60F89D0D1AE92" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsCommonStockCash_026C07B5321352B378C60F89D0D1AE92" xlink:to="lab_us-gaap_DividendsCommonStockCash_026C07B5321352B378C60F89D0D1AE92" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockholdersEquity_AD638EA1422B38818CA90F89D0D1B0E2_periodEndLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_AD638EA1422B38818CA90F89D0D1B0E2" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance, value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_AD638EA1422B38818CA90F89D0D1B0E2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity_AD638EA1422B38818CA90F89D0D1B0E2" xlink:to="lab_us-gaap_StockholdersEquity_AD638EA1422B38818CA90F89D0D1B0E2" xlink:type="arc" />
    <link:label id="lab_us-gaap_CommonStockSharesOutstanding_F7E0347F988BE2DAD8940F89D0D131BC_periodEndLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesOutstanding_F7E0347F988BE2DAD8940F89D0D131BC" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance, Common Stock, shares</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_F7E0347F988BE2DAD8940F89D0D131BC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesOutstanding_F7E0347F988BE2DAD8940F89D0D131BC" xlink:to="lab_us-gaap_CommonStockSharesOutstanding_F7E0347F988BE2DAD8940F89D0D131BC" xlink:type="arc" />
  </link:labelLink>
</link:linkbase>
