<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:924cbad4-b341-4f03-b050-39396e7cadd1,g:6742fcde-a1b3-483d-bebe-9bd395fb7e42-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.agnc.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="agnc-20200930.xsd#DocumentandEntityInformation"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DocumentandEntityInformation" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="agnc-20200930.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf7efb1c-f300-4522-b480-81947a7aa300" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_9d63cb67-9c85-465a-a2ce-bdd509a234a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf7efb1c-f300-4522-b480-81947a7aa300" xlink:to="loc_us-gaap_Liabilities_9d63cb67-9c85-465a-a2ce-bdd509a234a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7977c135-0db4-40a9-a2ca-7cb9fe7b3651" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf7efb1c-f300-4522-b480-81947a7aa300" xlink:to="loc_us-gaap_StockholdersEquity_7977c135-0db4-40a9-a2ca-7cb9fe7b3651" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_282262db-c1ea-4031-9a2d-99e8bd57b663" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_282262db-c1ea-4031-9a2d-99e8bd57b663" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_59cac1bc-0d78-4efd-876e-b79828520ad0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLongTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:to="loc_us-gaap_OtherLongTermDebt_59cac1bc-0d78-4efd-876e-b79828520ad0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_a0b5ed51-06e1-4075-9893-73e1347072fb" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_PayablesToBrokerDealersAndClearingOrganizations"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:to="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_a0b5ed51-06e1-4075-9893-73e1347072fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_1f619480-5f6b-40ea-939a-b9ba8b80ad53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:to="loc_us-gaap_DerivativeLiabilities_1f619480-5f6b-40ea-939a-b9ba8b80ad53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_7f7f54a6-dd85-4b18-969d-4aeab1cf6bb0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_7f7f54a6-dd85-4b18-969d-4aeab1cf6bb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_ad113216-8111-4ad4-840e-148381e627e6" xlink:href="agnc-20200930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_ad113216-8111-4ad4-840e-148381e627e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_13114813-f505-4c99-8fe8-f9e2d0689cf7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9464076a-8eaa-4fc4-8eba-07e3489e6313" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_13114813-f505-4c99-8fe8-f9e2d0689cf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_7b512dbd-a736-43a1-91e5-f1876d4b895e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_7b512dbd-a736-43a1-91e5-f1876d4b895e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_5039310f-b9b8-4276-aa2f-7ba7245f3e5c" xlink:href="agnc-20200930.xsd#agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_5039310f-b9b8-4276-aa2f-7ba7245f3e5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_891d7a74-4c34-4801-997f-00caa7894fef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_891d7a74-4c34-4801-997f-00caa7894fef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_43cbac01-f2da-413d-affb-7ddc10d81be5" xlink:href="agnc-20200930.xsd#agnc_NonAgencySecuritiesatFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_43cbac01-f2da-413d-affb-7ddc10d81be5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_589412fc-eba1-4e82-860c-8998b49aa9ae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_589412fc-eba1-4e82-860c-8998b49aa9ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_a3e235b6-62c3-4a7e-8355-738c1e21925d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_a3e235b6-62c3-4a7e-8355-738c1e21925d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_838d8c65-1a01-4483-ac40-53e99c2b9a57" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_838d8c65-1a01-4483-ac40-53e99c2b9a57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_500e7c42-10c6-4673-a9c2-d723ce135325" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_DerivativeAssets_500e7c42-10c6-4673-a9c2-d723ce135325" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_228647e5-23cc-4e56-b282-aeb504fabdbd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_228647e5-23cc-4e56-b282-aeb504fabdbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_a74685a5-c618-447d-a290-661c14b5d91b" xlink:href="agnc-20200930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_a74685a5-c618-447d-a290-661c14b5d91b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_5f2cfaf0-5c3b-4d3e-a70b-7d86ced05c2a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_5f2cfaf0-5c3b-4d3e-a70b-7d86ced05c2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_0ee8637f-fbbe-4488-ad8c-24d00393919e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_OtherAssets_0ee8637f-fbbe-4488-ad8c-24d00393919e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_a6cf2ca1-7b07-42d0-a36a-7d34d8759759" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ad1c5ceb-fe54-4f20-b36c-bca2e5852463" xlink:to="loc_us-gaap_AssetsCurrent_a6cf2ca1-7b07-42d0-a36a-7d34d8759759" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_0584c313-b244-49d1-9c45-a4244ec704fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_76c0f885-9a20-4fb3-a8c5-fcfa0b26c0f1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0584c313-b244-49d1-9c45-a4244ec704fe" xlink:to="loc_us-gaap_PreferredStockValue_76c0f885-9a20-4fb3-a8c5-fcfa0b26c0f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_a01fec5c-17b1-4116-999a-df226d2b7685" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0584c313-b244-49d1-9c45-a4244ec704fe" xlink:to="loc_us-gaap_CommonStockValue_a01fec5c-17b1-4116-999a-df226d2b7685" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_db4697ec-4d90-4f20-a031-a8e94d9587ae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0584c313-b244-49d1-9c45-a4244ec704fe" xlink:to="loc_us-gaap_AdditionalPaidInCapital_db4697ec-4d90-4f20-a031-a8e94d9587ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_46cd51b3-dfb9-4e96-ae9f-5a1f4da6e04d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0584c313-b244-49d1-9c45-a4244ec704fe" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_46cd51b3-dfb9-4e96-ae9f-5a1f4da6e04d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_cb38db81-3ab4-4840-9cde-61c0ccf15a65" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0584c313-b244-49d1-9c45-a4244ec704fe" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_cb38db81-3ab4-4840-9cde-61c0ccf15a65" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:type="simple" xlink:href="agnc-20200930.xsd#ConsolidatedBalanceSheetsParentheticals"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" xlink:href="agnc-20200930.xsd#ConsolidatedStatementsOfComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_4c1d5c05-871d-4e53-99b6-b4eacf30349f" xlink:href="agnc-20200930.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_88e56783-71b4-41c1-8447-467f5f2e8594" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_4c1d5c05-871d-4e53-99b6-b4eacf30349f" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_88e56783-71b4-41c1-8447-467f5f2e8594" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_dd5fe757-f329-4faf-b53a-11da549ecf0b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_4c1d5c05-871d-4e53-99b6-b4eacf30349f" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_dd5fe757-f329-4faf-b53a-11da549ecf0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_15b0b77b-de5b-4b6f-ab17-23da3201c34c" xlink:href="agnc-20200930.xsd#agnc_Issuancecostsofredeemedpreferredstock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_4c1d5c05-871d-4e53-99b6-b4eacf30349f" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_15b0b77b-de5b-4b6f-ab17-23da3201c34c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_b7ceae3f-a3c0-4344-a2e3-b67df3a2b19d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_f7972360-8d14-4073-a6af-64e258b81f17" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_b7ceae3f-a3c0-4344-a2e3-b67df3a2b19d" xlink:to="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_f7972360-8d14-4073-a6af-64e258b81f17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_2e7ac949-0658-4d03-aedb-17bd4b27a47f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_b7ceae3f-a3c0-4344-a2e3-b67df3a2b19d" xlink:to="loc_us-gaap_InterestExpense_2e7ac949-0658-4d03-aedb-17bd4b27a47f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b01032b7-5300-43f1-aca4-b0777f6772ff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d4a79b36-8291-46b4-a9bd-6a948f8ce56b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b01032b7-5300-43f1-aca4-b0777f6772ff" xlink:to="loc_us-gaap_NetIncomeLoss_d4a79b36-8291-46b4-a9bd-6a948f8ce56b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_ad1a21dd-45ef-41f7-8b89-0c087d9de231" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b01032b7-5300-43f1-aca4-b0777f6772ff" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_ad1a21dd-45ef-41f7-8b89-0c087d9de231" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_5a7d0c47-24af-4ed6-b203-66c82091690f" xlink:href="agnc-20200930.xsd#agnc_Issuancecostsofredeemedpreferredstock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b01032b7-5300-43f1-aca4-b0777f6772ff" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_5a7d0c47-24af-4ed6-b203-66c82091690f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_b0f6ff9e-1a55-461b-b1c9-c90710e69e22" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_18d5fa2f-2ddb-4c02-9c35-5c5e30540ad2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_b0f6ff9e-1a55-461b-b1c9-c90710e69e22" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_18d5fa2f-2ddb-4c02-9c35-5c5e30540ad2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_2fec6024-2c3a-48ac-89f5-1f014008f6e1" xlink:href="agnc-20200930.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_b0f6ff9e-1a55-461b-b1c9-c90710e69e22" xlink:to="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_2fec6024-2c3a-48ac-89f5-1f014008f6e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_f223d2cd-1228-43c2-9751-c72751fe85fc" xlink:href="agnc-20200930.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_b0f6ff9e-1a55-461b-b1c9-c90710e69e22" xlink:to="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_f223d2cd-1228-43c2-9751-c72751fe85fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_94f56e23-e33d-40be-ba10-8fff3d23d1f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_65946f1a-27b3-47c8-965a-bab31a029916" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_94f56e23-e33d-40be-ba10-8fff3d23d1f2" xlink:to="loc_us-gaap_NetIncomeLoss_65946f1a-27b3-47c8-965a-bab31a029916" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_ef628724-ec30-431a-80cf-5e98a3acbcfc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_94f56e23-e33d-40be-ba10-8fff3d23d1f2" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_ef628724-ec30-431a-80cf-5e98a3acbcfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_ecdf0dad-8bbd-4383-8352-96d970d8327e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_90c89c4c-988c-419b-a135-17d0119cb28f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_ecdf0dad-8bbd-4383-8352-96d970d8327e" xlink:to="loc_us-gaap_LaborAndRelatedExpense_90c89c4c-988c-419b-a135-17d0119cb28f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_cae785fb-07a8-40fc-a735-ffa0d5fa6eef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_ecdf0dad-8bbd-4383-8352-96d970d8327e" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_cae785fb-07a8-40fc-a735-ffa0d5fa6eef" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="simple" xlink:href="agnc-20200930.xsd#ConsolidatedStatementofStockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="agnc-20200930.xsd#ConsolidatedStatementsOfCashFlows"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_2da90d0c-f970-4f38-814a-70d2b4842eec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_2da90d0c-f970-4f38-814a-70d2b4842eec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_3a520635-bb5c-45e6-8fdb-6665a2c08bde" xlink:href="agnc-20200930.xsd#agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_3a520635-bb5c-45e6-8fdb-6665a2c08bde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_495a2bde-d4c7-4060-b755-567ad61a9921" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_495a2bde-d4c7-4060-b755-567ad61a9921" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_25d2153f-d085-4583-a6b8-7a2de2d12028" xlink:href="agnc-20200930.xsd#agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_25d2153f-d085-4583-a6b8-7a2de2d12028" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_81c86a44-479a-4222-a4bd-72c37f89f2f2" xlink:href="agnc-20200930.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_81c86a44-479a-4222-a4bd-72c37f89f2f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_44e2aeba-2bf3-4e04-afde-ec37a9d60b63" xlink:href="agnc-20200930.xsd#agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_44e2aeba-2bf3-4e04-afde-ec37a9d60b63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_60303fda-4221-48a9-8bcf-6f2ad6657bb6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_60303fda-4221-48a9-8bcf-6f2ad6657bb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_90c1f04f-a261-49c8-a348-0557462efcc8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_90c1f04f-a261-49c8-a348-0557462efcc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_ec87b078-4a28-499a-9e9f-fe9dc5299f69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_ec87b078-4a28-499a-9e9f-fe9dc5299f69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_bb13a8a1-0c37-450e-92ee-929200d779e2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f56dcdd-3826-49a9-9d53-e24b381104f9" xlink:to="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_bb13a8a1-0c37-450e-92ee-929200d779e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3112ad0e-6719-4760-9795-f6b88781642e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0862474a-ae02-4be6-9e9b-5d5297b9a822" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3112ad0e-6719-4760-9795-f6b88781642e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0862474a-ae02-4be6-9e9b-5d5297b9a822" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9c61368c-4f88-4218-a589-7ef4bbe5ca38" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3112ad0e-6719-4760-9795-f6b88781642e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9c61368c-4f88-4218-a589-7ef4bbe5ca38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4606d62b-107a-4f0d-a216-60e263bdc1d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3112ad0e-6719-4760-9795-f6b88781642e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4606d62b-107a-4f0d-a216-60e263bdc1d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_5f868cbe-7bc6-4aee-836b-034b2f99ba6d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromShortTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_5f868cbe-7bc6-4aee-836b-034b2f99ba6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_298a44ac-761e-470a-a20a-a74b3c5f3e0c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfShortTermDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_298a44ac-761e-470a-a20a-a74b3c5f3e0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_41362a4c-e476-4006-aaa6-23642ca3e962" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfOtherDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_41362a4c-e476-4006-aaa6-23642ca3e962" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_a71279bb-01bf-42b2-9953-59f10d73e99b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_a71279bb-01bf-42b2-9953-59f10d73e99b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_9a0cd1ca-f7bd-4612-bc33-d46679ea51f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_9a0cd1ca-f7bd-4612-bc33-d46679ea51f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_e795ecf0-4a70-4930-bd9e-ddbd7056691b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_e795ecf0-4a70-4930-bd9e-ddbd7056691b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_ef8f913d-c078-4f46-8f13-d9ff16c1fa10" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_ef8f913d-c078-4f46-8f13-d9ff16c1fa10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_08b91d8d-49ff-428d-b4c1-2e29eb2af0a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_08b91d8d-49ff-428d-b4c1-2e29eb2af0a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_aaac86f6-36bd-4c59-a55e-07947e32bb45" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDividends"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_039f7af0-fbdf-41d2-a0fc-3024e50c824a" xlink:to="loc_us-gaap_PaymentsOfDividends_aaac86f6-36bd-4c59-a55e-07947e32bb45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f46b5773-00dd-41ab-8697-38895de718e5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_us-gaap_NetIncomeLoss_f46b5773-00dd-41ab-8697-38895de718e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_79abad20-50dc-4132-8598-fe35e4b74d42" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_79abad20-50dc-4132-8598-fe35e4b74d42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_74087f2f-c42b-40dd-ae02-959bd85df242" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_74087f2f-c42b-40dd-ae02-959bd85df242" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_a20013a5-0952-4642-85fa-1d91faa19c9f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_us-gaap_ShareBasedCompensation_a20013a5-0952-4642-85fa-1d91faa19c9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_4b0b59c0-9a8a-4a9f-8de9-a246714af6dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_4b0b59c0-9a8a-4a9f-8de9-a246714af6dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_7c4d749a-d888-440d-b644-c54d0c683e5e" xlink:href="agnc-20200930.xsd#agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_7c4d749a-d888-440d-b644-c54d0c683e5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_235b7f06-eb01-45d7-8fdd-1ce0b47c3e0d" xlink:href="agnc-20200930.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_235b7f06-eb01-45d7-8fdd-1ce0b47c3e0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_f6ade3e3-6b97-4352-b159-c8b22ab6cbde" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_f6ade3e3-6b97-4352-b159-c8b22ab6cbde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_b4cda14b-d4f8-43af-b22a-58f5984fb4e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9980a33d-fc05-43c1-a5ec-b3c8db2ae5c7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_b4cda14b-d4f8-43af-b22a-58f5984fb4e6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:type="simple" xlink:href="agnc-20200930.xsd#UnauditedInterimConsolidatedFinancialStatements"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/Organization" xlink:type="simple" xlink:href="agnc-20200930.xsd#Organization"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/Organization" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/OrganizationDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#OrganizationDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/OrganizationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="agnc-20200930.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesPolicy" xlink:type="simple" xlink:href="agnc-20200930.xsd#SummaryofSignificantAccountingPoliciesPolicy"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesPolicy" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="simple" xlink:href="agnc-20200930.xsd#SummaryofSignificantAccountingPoliciesAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#SummaryofSignificantAccountingPoliciesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesGoodwillandIntangibleAssetsDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#SummaryofSignificantAccountingPoliciesGoodwillandIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesGoodwillandIntangibleAssetsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#SummaryofSignificantAccountingPoliciesVariableInterestEntitiesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecurities" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecurities"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecurities" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesTables"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryofInvestmentinAgencySecurityDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesInvestmentSecuritiesSummaryofInvestmentinAgencySecurityDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryofInvestmentinAgencySecurityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOCIForAvailableForSaleSecurityDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesSummaryOfChangesInAccumulatedOCIForAvailableForSaleSecurityDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOCIForAvailableForSaleSecurityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_a9142353-2a8a-4582-afd6-307eb597d046" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_67a418e2-fc2d-4a69-bf2d-6f9510f8fb9b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_a9142353-2a8a-4582-afd6-307eb597d046" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_67a418e2-fc2d-4a69-bf2d-6f9510f8fb9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_6ef9cc1c-294f-4cdd-9917-18de27ff7db9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_a9142353-2a8a-4582-afd6-307eb597d046" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_6ef9cc1c-294f-4cdd-9917-18de27ff7db9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_6706a3b1-01e9-449a-9795-e4e6abcc73c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_bacd668e-7f6a-4e7e-bd4c-a5d5cd2fc52c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_6706a3b1-01e9-449a-9795-e4e6abcc73c2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_bacd668e-7f6a-4e7e-bd4c-a5d5cd2fc52c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_92c18a7a-1fa1-478c-9539-efa6df6f247c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_6706a3b1-01e9-449a-9795-e4e6abcc73c2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_92c18a7a-1fa1-478c-9539-efa6df6f247c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesbyCreditRatingDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#InvestmentSecuritiesSecuritiesbyCreditRatingDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesbyCreditRatingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="simple" xlink:href="agnc-20200930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreements"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsandReverseRepurchaseAgreementsTables" xlink:type="simple" xlink:href="agnc-20200930.xsd#RepurchaseAgreementsandReverseRepurchaseAgreementsTables"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsandReverseRepurchaseAgreementsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstruments" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstruments"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstruments" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTables" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsTables"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsFairValueInformationDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsUSTreasurySecuritiesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsUSTreasurySecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsUSTreasurySecuritiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTBASecuritiesbyCouponandIssuerDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsTBASecuritiesbyCouponandIssuerDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTBASecuritiesbyCouponandIssuerDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#DerivativeandOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssets" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssets"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssets" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssetsTables"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssetsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementswithCounterpartiesGreaterthanorEqualto5ofEquityatRiskDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssetsRepurchaseAgreementswithCounterpartiesGreaterthanorEqualto5ofEquityatRiskDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementswithCounterpartiesGreaterthanorEqualto5ofEquityatRiskDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedasCollateralDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssetsAssetsPledgedasCollateralDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedasCollateralDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedasCollateralDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssetsSecuritiesPledgedasCollateralDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedasCollateralDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedfromCounterpartiesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssetsAssetsPledgedfromCounterpartiesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedfromCounterpartiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#PledgedAssetsOffsettingAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsandLiabilitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="agnc-20200930.xsd#FairValueMeasurements"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurements" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="agnc-20200930.xsd#FairValueMeasurementsTables"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#FairValueMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:type="simple" xlink:href="agnc-20200930.xsd#NetIncomeLossPerCommonShareNotes"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:type="simple" xlink:href="agnc-20200930.xsd#NetIncomeLossPerCommonShareTables"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#NetIncomeLossPerCommonShareDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquity" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityTables"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityPreferredStockDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityCommonStockRepurchaseProgramDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityFollowOnEquityOfferingsDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAttheMarketOfferingProgramDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityAttheMarketOfferingProgramDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAttheMarketOfferingProgramDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentandDirectStockPurchasePlanDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityDividendReinvestmentandDirectStockPurchasePlanDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentandDirectStockPurchasePlanDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityLongtermIncentivePlanDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityLongtermIncentivePlanDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityLongtermIncentivePlanDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityScheduleofDividendsDeclaredDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#StockholdersEquityScheduleofDividendsDeclaredDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityScheduleofDividendsDeclaredDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEvent" xlink:type="simple" xlink:href="agnc-20200930.xsd#SubsequentEvent"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SubsequentEvent" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="simple" xlink:href="agnc-20200930.xsd#SubsequentEventDetails"/>
  <link:calculationLink xlink:role="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="extended"/>
</link:linkbase>
