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    <link:loc xlink:href="agnc-20190630.xsd#agnc_WeightedAverageLifeOtherDebt" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_19DE5DFA698ADFF5B7D05405197F997B" xlink:type="locator" />
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_EC8EB96A782B26B024F05D8C8FF5024D" xlink:type="locator" />
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    <link:label id="lab_invest_InvestmentAxis_744CF3F7B8AFF990B7F75D8C8FF77B35_label_en-US" xlink:label="lab_invest_InvestmentAxis_744CF3F7B8AFF990B7F75D8C8FF77B35" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_744CF3F7B8AFF990B7F75D8C8FF77B35" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentAxis_744CF3F7B8AFF990B7F75D8C8FF77B35" xlink:to="lab_invest_InvestmentAxis_744CF3F7B8AFF990B7F75D8C8FF77B35" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentDomain_76F4BF472EC89787A2475D8C8FF7BE03_terseLabel_en-US" xlink:label="lab_invest_InvestmentDomain_76F4BF472EC89787A2475D8C8FF7BE03" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:label id="lab_invest_InvestmentDomain_76F4BF472EC89787A2475D8C8FF7BE03_label_en-US" xlink:label="lab_invest_InvestmentDomain_76F4BF472EC89787A2475D8C8FF7BE03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_76F4BF472EC89787A2475D8C8FF7BE03" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentDomain_76F4BF472EC89787A2475D8C8FF7BE03" xlink:to="lab_invest_InvestmentDomain_76F4BF472EC89787A2475D8C8FF7BE03" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_6D54C463FC2EB427F25F5D8C8FF943E2_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_6D54C463FC2EB427F25F5D8C8FF943E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]</link:label>
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_6D54C463FC2EB427F25F5D8C8FF943E2_label_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_6D54C463FC2EB427F25F5D8C8FF943E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_6D54C463FC2EB427F25F5D8C8FF943E2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_6D54C463FC2EB427F25F5D8C8FF943E2" xlink:to="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_6D54C463FC2EB427F25F5D8C8FF943E2" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_DAEFC90752D1F96BE8DA5D8C8FF96513_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_DAEFC90752D1F96BE8DA5D8C8FF96513" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Domain]</link:label>
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_DAEFC90752D1F96BE8DA5D8C8FF96513_label_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_DAEFC90752D1F96BE8DA5D8C8FF96513" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_DAEFC90752D1F96BE8DA5D8C8FF96513" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_DAEFC90752D1F96BE8DA5D8C8FF96513" xlink:to="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_DAEFC90752D1F96BE8DA5D8C8FF96513" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityOvernightMember_F0B26730A62C7191960F5D8C8FF943BD_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_F0B26730A62C7191960F5D8C8FF943BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityOvernightMember_F0B26730A62C7191960F5D8C8FF943BD_label_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_F0B26730A62C7191960F5D8C8FF943BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_F0B26730A62C7191960F5D8C8FF943BD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityOvernightMember_F0B26730A62C7191960F5D8C8FF943BD" xlink:to="lab_us-gaap_MaturityOvernightMember_F0B26730A62C7191960F5D8C8FF943BD" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_AE30616CAD62A65FF19C5D8C8FFAB522_verboseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_AE30616CAD62A65FF19C5D8C8FFAB522" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">30 Days or Less [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_AE30616CAD62A65FF19C5D8C8FFAB522_label_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_AE30616CAD62A65FF19C5D8C8FFAB522" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Less than 30 Days [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_AE30616CAD62A65FF19C5D8C8FFAB522" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_AE30616CAD62A65FF19C5D8C8FFAB522" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_AE30616CAD62A65FF19C5D8C8FFAB522" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">1 to 3 Months</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52_label_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52_documentation_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52" xlink:to="lab_agnc_ThirtyOneToNinetyMember_E4DB8FDD2D475875F3B15D8C8FFAAE52" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3 to 6 Months</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F_label_en-US" xlink:label="lab_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F_documentation_en-US" xlink:label="lab_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F" xlink:to="lab_agnc_A4to6MonthsMember_4589620F48031E5D9E4C5D8C8FFA1C6F" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_C55BDB81F730C85306F45D8C8FFA84B2_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_C55BDB81F730C85306F45D8C8FFA84B2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_C55BDB81F730C85306F45D8C8FFA84B2_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_C55BDB81F730C85306F45D8C8FFA84B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_C55BDB81F730C85306F45D8C8FFA84B2_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_C55BDB81F730C85306F45D8C8FFA84B2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_C55BDB81F730C85306F45D8C8FFA84B2" xlink:type="locator" />
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    <link:label id="lab_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B" xlink:to="lab_agnc_A10to12MonthsMember_AF955C5523B3411C2BBD5D8C8FFB6F0B" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6" xlink:to="lab_agnc_A13to24MonthsMember_B922118D167F0C1FAA275D8C8FFBCFA6" xlink:type="arc" />
    <link:label id="lab_agnc_A25to36monthsMember_4666BFFCA6D46B8D85C15D8C8FFBF775_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_4666BFFCA6D46B8D85C15D8C8FFBF775" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_4666BFFCA6D46B8D85C15D8C8FFBF775_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_4666BFFCA6D46B8D85C15D8C8FFBF775" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_4666BFFCA6D46B8D85C15D8C8FFBF775_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_4666BFFCA6D46B8D85C15D8C8FFBF775" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_4666BFFCA6D46B8D85C15D8C8FFBF775" xlink:type="locator" />
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    <link:label id="lab_agnc_A37to48monthsMember_B97CEB4C3E25C414B7E95D8C8FFBD1D4_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_B97CEB4C3E25C414B7E95D8C8FFBD1D4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_B97CEB4C3E25C414B7E95D8C8FFBD1D4_label_en-US" xlink:label="lab_agnc_A37to48monthsMember_B97CEB4C3E25C414B7E95D8C8FFBD1D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_B97CEB4C3E25C414B7E95D8C8FFBD1D4_documentation_en-US" xlink:label="lab_agnc_A37to48monthsMember_B97CEB4C3E25C414B7E95D8C8FFBD1D4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_B97CEB4C3E25C414B7E95D8C8FFBD1D4" xlink:type="locator" />
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    <link:label id="lab_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E_label_en-US" xlink:label="lab_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E_documentation_en-US" xlink:label="lab_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E" xlink:to="lab_agnc_A49to60MonthsMember_C382D5828CC6ACA8FF825D8C8FFB109E" xlink:type="arc" />
    <link:label id="lab_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882_terseLabel_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882_label_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882_documentation_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">U.S. Treasury Repurchase Agreements from 2 Days to 1 Month [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882" xlink:to="lab_agnc_A2Daysto1MonthMember_8625B9ACC7370218CECE5D8C8FFC1882" xlink:type="arc" />
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_EFFCE8D69E2172BE247C5D8D1960F4CC_terseLabel_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_EFFCE8D69E2172BE247C5D8D1960F4CC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_EFFCE8D69E2172BE247C5D8D1960F4CC_label_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_EFFCE8D69E2172BE247C5D8D1960F4CC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_EFFCE8D69E2172BE247C5D8D1960F4CC_documentation_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_EFFCE8D69E2172BE247C5D8D1960F4CC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_EFFCE8D69E2172BE247C5D8D1960F4CC" xlink:type="locator" />
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    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_B03AD9D5399CCE25745A5D8C8FFCCB96_verboseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_B03AD9D5399CCE25745A5D8C8FFCCB96" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_B03AD9D5399CCE25745A5D8C8FFCCB96" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_B03AD9D5399CCE25745A5D8C8FFCCB96" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_B03AD9D5399CCE25745A5D8C8FFCCB96" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_2844D512B396CE34C52D5D8C8FFC1688_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_2844D512B396CE34C52D5D8C8FFC1688" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_2844D512B396CE34C52D5D8C8FFC1688_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_2844D512B396CE34C52D5D8C8FFC1688" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate, at Point in Time</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_2844D512B396CE34C52D5D8C8FFC1688" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_2844D512B396CE34C52D5D8C8FFC1688" xlink:to="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_2844D512B396CE34C52D5D8C8FFC1688" xlink:type="arc" />
    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_351A5AC66F296A1499235D8C8FFC528A_terseLabel_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_351A5AC66F296A1499235D8C8FFC528A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Obligation to Return Securities Borrowed Under Reverse Repurchase Agreements at Fair Value</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_351A5AC66F296A1499235D8C8FFC528A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_351A5AC66F296A1499235D8C8FFC528A" xlink:to="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_351A5AC66F296A1499235D8C8FFC528A" xlink:type="arc" />
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_390CF82A1CECFB191B5454037F3E7830_terseLabel_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis_390CF82A1CECFB191B5454037F3E7830" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_390CF82A1CECFB191B5454037F3E7830_label_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis_390CF82A1CECFB191B5454037F3E7830" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_390CF82A1CECFB191B5454037F3E7830_documentation_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis_390CF82A1CECFB191B5454037F3E7830" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_DerivativeByMaturityYearsAxis" xlink:label="loc_agnc_DerivativeByMaturityYearsAxis_390CF82A1CECFB191B5454037F3E7830" xlink:type="locator" />
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    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_0717676394FA5098775B54037F3ED749_terseLabel_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain_0717676394FA5098775B54037F3ED749" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_0717676394FA5098775B54037F3ED749_label_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain_0717676394FA5098775B54037F3ED749" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative By Maturity Years [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_0717676394FA5098775B54037F3ED749_documentation_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain_0717676394FA5098775B54037F3ED749" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Derivative By Maturity Years [Axis]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_DerivativeByMaturityYearsDomain" xlink:label="loc_agnc_DerivativeByMaturityYearsDomain_0717676394FA5098775B54037F3ED749" xlink:type="locator" />
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    <link:label id="lab_agnc_A30YearMaturityMember_E51D93EBF87B2B939E6754037F3E0658_terseLabel_en-US" xlink:label="lab_agnc_A30YearMaturityMember_E51D93EBF87B2B939E6754037F3E0658" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">30 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A30YearMaturityMember_E51D93EBF87B2B939E6754037F3E0658_label_en-US" xlink:label="lab_agnc_A30YearMaturityMember_E51D93EBF87B2B939E6754037F3E0658" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">30 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A30YearMaturityMember_E51D93EBF87B2B939E6754037F3E0658_documentation_en-US" xlink:label="lab_agnc_A30YearMaturityMember_E51D93EBF87B2B939E6754037F3E0658" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">30 Year Maturity [Member]</link:label>
    <link:loc xlink:href="agnc-20190630.xsd#agnc_A30YearMaturityMember" xlink:label="loc_agnc_A30YearMaturityMember_E51D93EBF87B2B939E6754037F3E0658" xlink:type="locator" />
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    <link:label id="lab_agnc_A15YearMaturityMember_DE1679E33A38EB99AC4254037F3F3EEA_label_en-US" xlink:label="lab_agnc_A15YearMaturityMember_DE1679E33A38EB99AC4254037F3F3EEA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">15 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A15YearMaturityMember_DE1679E33A38EB99AC4254037F3F3EEA_documentation_en-US" xlink:label="lab_agnc_A15YearMaturityMember_DE1679E33A38EB99AC4254037F3F3EEA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">15 Year Maturity [Member]</link:label>
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    <link:label id="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_03BFD61CDC64FC5008455414FA3F7950_label_en-US" xlink:label="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_03BFD61CDC64FC5008455414FA3F7950" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Receivables from Broker-Dealers and Clearing Organizations</link:label>
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    <link:label id="lab_us-gaap_OtherAssets_219BE92FD6ED52546E595414FA400359_label_en-US" xlink:label="lab_us-gaap_OtherAssets_219BE92FD6ED52546E595414FA400359" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Assets</link:label>
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    <link:label id="lab_us-gaap_LiabilitiesAbstract_35D7C5EC269CEA7473955414FA40A027_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract_35D7C5EC269CEA7473955414FA40A027" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liabilities [Abstract]</link:label>
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    <link:label id="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_275D269F10BD4356AA9E5414FA410608_label_en-US" xlink:label="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_275D269F10BD4356AA9E5414FA410608" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends Payable</link:label>
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    <link:label id="lab_agnc_PreferredStockDValueIssued_F3101499A9A80CEAC2555414FA433A0B_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockDValueIssued_F3101499A9A80CEAC2555414FA433A0B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">6.875% Series D Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock (aggregate liquidation preference of $235)</link:label>
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