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    <link:loc xlink:href="agnc-20170930.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_36F25418965AA6428A1BADEB66F41DC9" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_36F25418965AA6428A1BADEB66F41DC9" xlink:to="lab_agnc_A4to6MonthsMember_36F25418965AA6428A1BADEB66F41DC9" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD" xlink:to="lab_agnc_A7to9monthsMember_0CEF82F7430C91B43108ADEB66F4BEFD" xlink:type="arc" />
    <link:label id="lab_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72" xlink:to="lab_agnc_A10to12MonthsMember_68D44252BF85AA80722FADEB66F4BF72" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940" xlink:to="lab_agnc_A13to24MonthsMember_10E036B683E3C311DC02ADEB66F4E940" xlink:type="arc" />
    <link:label id="lab_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC" xlink:to="lab_agnc_A25to36monthsMember_7161087025F23C9F4840ADEB66F4D2DC" xlink:type="arc" />
    <link:label id="lab_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2_label_en-US" xlink:label="lab_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2_documentation_en-US" xlink:label="lab_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2" xlink:to="lab_agnc_A37to48monthsMember_CD1D3A068A412299F223ADEB66F4FFA2" xlink:type="arc" />
    <link:label id="lab_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8_label_en-US" xlink:label="lab_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8_documentation_en-US" xlink:label="lab_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8" xlink:to="lab_agnc_A49to60MonthsMember_DAAB3897036FBE196F35ADEB66F44FD8" xlink:type="arc" />
    <link:label id="lab_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC_terseLabel_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC_label_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC_documentation_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">U.S. Treasury Repurchase Agreements from 2 Days to 1 Month [Member]</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC" xlink:to="lab_agnc_A2Daysto1MonthMember_8D5F93B000D311822254ADEB66F412FC" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_BAB082B4B2287C5B1DF6ADEB66F45287_verboseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_BAB082B4B2287C5B1DF6ADEB66F45287" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements</link:label>
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_BAB082B4B2287C5B1DF6ADEB66F45287_label_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_BAB082B4B2287C5B1DF6ADEB66F45287" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Securities Sold under Agreements to Repurchase</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_BAB082B4B2287C5B1DF6ADEB66F45287" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_BAB082B4B2287C5B1DF6ADEB66F45287" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_BAB082B4B2287C5B1DF6ADEB66F45287" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_81ED506EEC445DCFBA0BADEB66F40AC7_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_81ED506EEC445DCFBA0BADEB66F40AC7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_81ED506EEC445DCFBA0BADEB66F40AC7_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_81ED506EEC445DCFBA0BADEB66F40AC7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate, at Point in Time</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_81ED506EEC445DCFBA0BADEB66F40AC7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_81ED506EEC445DCFBA0BADEB66F40AC7" xlink:to="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_81ED506EEC445DCFBA0BADEB66F40AC7" xlink:type="arc" />
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Days to Maturity</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5_label_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Repurchase Agreements Weighted Average Days To Maturity</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Repurchase Agreements Weighted Average Days To Maturity</link:label>
    <link:loc xlink:href="agnc-20170930.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5" xlink:to="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_6A21F3D1A482DD0F56D3ADEB66F455D5" xlink:type="arc" />
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_85A3051C3393D35731B1ADEB6778CCF7_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_85A3051C3393D35731B1ADEB6778CCF7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Goodwill and Intangible Assets Disclosure [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_85A3051C3393D35731B1ADEB6778CCF7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_85A3051C3393D35731B1ADEB6778CCF7" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_85A3051C3393D35731B1ADEB6778CCF7" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4D5C710B1EADC7AF1DCBADEB677824D0_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4D5C710B1EADC7AF1DCBADEB677824D0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4D5C710B1EADC7AF1DCBADEB677824D0_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4D5C710B1EADC7AF1DCBADEB677824D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4D5C710B1EADC7AF1DCBADEB677824D0" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4D5C710B1EADC7AF1DCBADEB677824D0" xlink:to="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4D5C710B1EADC7AF1DCBADEB677824D0" xlink:type="arc" />
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0032ABF8F4841A039FFEADEB6778B431_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0032ABF8F4841A039FFEADEB6778B431" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets by Major Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0032ABF8F4841A039FFEADEB6778B431_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0032ABF8F4841A039FFEADEB6778B431" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets by Major Class [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0032ABF8F4841A039FFEADEB6778B431" xlink:type="locator" />
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    <link:label id="lab_agnc_UnderlyingCollateralCoupon_CD0B24964A6DD0C0DFEE81ABFECFE43B_label_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon_CD0B24964A6DD0C0DFEE81ABFECFE43B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Underlying Collateral Coupon</link:label>
    <link:label id="lab_agnc_UnderlyingCollateralCoupon_CD0B24964A6DD0C0DFEE81ABFECFE43B_documentation_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon_CD0B24964A6DD0C0DFEE81ABFECFE43B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Underlying Collateral Coupon</link:label>
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    <link:label id="lab_us-gaap_SecuritiesHeldAsCollateralAtFairValue_93B060BC4C993052DF2781ABFECFE675_verboseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesHeldAsCollateralAtFairValue_93B060BC4C993052DF2781ABFECFE675" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities, total fair value</link:label>
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    <link:label id="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_8197728904469374CC2F81ABFECF3F4F_verboseLabel_en-US" xlink:label="lab_agnc_FairValueOfCmoSecuritiesDirectlyHeld_8197728904469374CC2F81ABFECF3F4F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fair value of CMO securities and interest-only and principal-only strips</link:label>
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    <link:label id="lab_us-gaap_LiabilitiesAbstract_3F47A41A45F97B7B24A67F6B2AA2CD65_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract_3F47A41A45F97B7B24A67F6B2AA2CD65" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liabilities [Abstract]</link:label>
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    <link:label id="lab_agnc_PreferredStockAValueIssued_AD197592387189E02A4A7F6B2AA3616A_label_en-US" xlink:label="lab_agnc_PreferredStockAValueIssued_AD197592387189E02A4A7F6B2AA3616A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock A, Value, Issued</link:label>
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    <link:label id="lab_agnc_PreferredStockCValueIssued_D3836A609F820ED3227F7F6B2AA33544_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockCValueIssued_D3836A609F820ED3227F7F6B2AA33544" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">7.000% Series C Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock (aggregate liquidation preference of $325 and $0, respectively)</link:label>
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    <link:label id="lab_us-gaap_CommonStockValue_6C8F1002112F2B3791777F6B2AA357A4_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockValue_6C8F1002112F2B3791777F6B2AA357A4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Common stock - $0.01 par value; 600 shares authorized; 391.3 and 331.0 shares issued and outstanding, respectively</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_39AECD53F305A4ECE93B7F6B2AA3A7C6" xlink:type="locator" />
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    <link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_058A21998666CF64A48B7F6B2AA37D9E_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit_058A21998666CF64A48B7F6B2AA37D9E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Retained Earnings (Accumulated Deficit)</link:label>
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    <link:label id="lab_us-gaap_StockholdersEquity_F9E31B3F42545F95AAE17F6B2AA4124B_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity_F9E31B3F42545F95AAE17F6B2AA4124B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stockholders' Equity Attributable to Parent</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_F9E31B3F42545F95AAE17F6B2AA4124B" xlink:type="locator" />
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    <link:label id="lab_agnc_PreferredStockBLiquidationPreferenceValue_C7D412A0DC2E74F136F57F6BA4F2FCAA_documentation_en-US" xlink:label="lab_agnc_PreferredStockBLiquidationPreferenceValue_C7D412A0DC2E74F136F57F6BA4F2FCAA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated values of the preferred B shares.</link:label>
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    <link:label id="lab_us-gaap_ShortTermDebtLineItems_C9769CADCA98D90AF455ADEB683C462D_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems_C9769CADCA98D90AF455ADEB683C462D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
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    <link:label id="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_A2E8F9ED75B701D42BA4ADEB683C5498_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_A2E8F9ED75B701D42BA4ADEB683C5498" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Percentage Bearing Fixed Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_A2E8F9ED75B701D42BA4ADEB683C5498_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_A2E8F9ED75B701D42BA4ADEB683C5498" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Percentage Bearing Fixed Interest Rate</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShortTermDebtPercentageBearingFixedInterestRate" xlink:label="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_A2E8F9ED75B701D42BA4ADEB683C5498" xlink:type="locator" />
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