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    <link:label id="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_13C44C0694EFB71DEB3FFB3072DDC5F0_documentation_en-US" xlink:label="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_13C44C0694EFB71DEB3FFB3072DDC5F0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The cash inflow from collection of principal from borrowers on mortgage backed securities held.</link:label>
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    <link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_76DD35F9F11D9ADE9840FB3072DE30E0_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_76DD35F9F11D9ADE9840FB3072DE30E0" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Payments on U.S. Treasury securities</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_76DD35F9F11D9ADE9840FB3072DE30E0_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_76DD35F9F11D9ADE9840FB3072DE30E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payments to Acquire Available-for-sale Securities</link:label>
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    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_8A5D6A8065E532D02E25FF3F59D8DEBB_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_8A5D6A8065E532D02E25FF3F59D8DEBB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash and cash equivalents</link:label>
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    <link:label id="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_5390FF980B36BF3B5201FF3F59DA550B_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_5390FF980B36BF3B5201FF3F59DA550B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Intangible Assets, Net (Including Goodwill)</link:label>
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    <link:label id="lab_us-gaap_OtherAssets_9CA52EBED0D702750B27FF3F59DAD80A_label_en-US" xlink:label="lab_us-gaap_OtherAssets_9CA52EBED0D702750B27FF3F59DAD80A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Assets</link:label>
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    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_42D8E851F1305F04B0E8880811109452" xlink:to="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_42D8E851F1305F04B0E8880811109452" xlink:type="arc" />
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_20C34CC175509034A88473CF596D42B1_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets Sold under Agreements to Repurchase, Type [Domain]</link:label>
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_20C34CC175509034A88473CF596D42B1_label_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets Sold under Agreements to Repurchase, Type [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:to="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:type="arc" />
    <link:label id="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A4E0F8E97429EC91434873CF59BA140A_terseLabel_en-US" xlink:label="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_8B63FDD09E685C4F8DFB217241D9B65E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">US Government Agencies Debt Securities [Member]</link:label>
    <link:label id="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A4E0F8E97429EC91434873CF59BA140A_label_en-US" xlink:label="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_8B63FDD09E685C4F8DFB217241D9B65E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">US Government Agencies Debt Securities [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_8B63FDD09E685C4F8DFB217241D9B65E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_8B63FDD09E685C4F8DFB217241D9B65E" xlink:to="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_8B63FDD09E685C4F8DFB217241D9B65E" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentAxis_767A8C70B4CA4D9C21E673C00C7584B2_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentAxis_767A8C70B4CA4D9C21E673C00C7584B2_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:to="lab_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:type="arc" />
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_1D433AE1998E56F42AED73C00C76538A_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_1D433AE1998E56F42AED73C00C76538A_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:to="lab_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_04BE9742139215052E0373C00C771423_verboseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_851E5F1443705216BE31BD5BDC4E28DC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">30 Days or Less [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_851E5F1443705216BE31BD5BDC4E28DC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_851E5F1443705216BE31BD5BDC4E28DC" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_851E5F1443705216BE31BD5BDC4E28DC" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_31CE111C66CA2033DEB973C00C778BAF_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">1 to 3 Months</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_31CE111C66CA2033DEB973C00C778BAF_label_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_31CE111C66CA2033DEB973C00C778BAF_documentation_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:to="lab_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_BEE269E914FD35B1C61673C00C77AF1F_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3 to 6 Months</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_BEE269E914FD35B1C61673C00C77AF1F_label_en-US" xlink:label="lab_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_BEE269E914FD35B1C61673C00C77AF1F_documentation_en-US" xlink:label="lab_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:to="lab_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_5DBF5999018741DDDB8273C00C7779FE_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_5DBF5999018741DDDB8273C00C7779FE_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_5DBF5999018741DDDB8273C00C7779FE_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:to="lab_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:type="arc" />
    <link:label id="lab_agnc_A10to12MonthsMember_287C3C72D7A40D97B9A373C00C778ACE_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_287C3C72D7A40D97B9A373C00C778ACE_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_287C3C72D7A40D97B9A373C00C778ACE_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:to="lab_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_8A628DE99F2B290D964D73C00C78D184_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_8A628DE99F2B290D964D73C00C78D184_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_8A628DE99F2B290D964D73C00C78D184_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:to="lab_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:type="arc" />
    <link:label id="lab_agnc_A25to36monthsMember_644D49A6DA9AA4C414E073C00C78F774_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_644D49A6DA9AA4C414E073C00C78F774_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_644D49A6DA9AA4C414E073C00C78F774_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:to="lab_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:type="arc" />
    <link:label id="lab_agnc_A37to48monthsMember_CE091C7A3CF39E81452D73C00C78C84E_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_CE091C7A3CF39E81452D73C00C78C84E_label_en-US" xlink:label="lab_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_CE091C7A3CF39E81452D73C00C78C84E_documentation_en-US" xlink:label="lab_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:to="lab_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:type="arc" />
    <link:label id="lab_agnc_A49to60MonthsMember_138AF917BD5E2C82749A73C00C78E8A5_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_138AF917BD5E2C82749A73C00C78E8A5_label_en-US" xlink:label="lab_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_138AF917BD5E2C82749A73C00C78E8A5_documentation_en-US" xlink:label="lab_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:to="lab_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_9F9EFC8D5E0FA5322EC173C00C79F461_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_74F99A29F8595A5FA5B5EF5D29C2EFEE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Interest Rate</link:label>
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