<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:1d86fa4c-a7ad-40dc-b886-29bc7859f863,g:28c5fecd-d450-46e6-b014-b84e260ae48f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.agnc.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="agnc-20220930.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_cae6ba1e-f7b2-4467-a1b1-056fb9023c5a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_feb21b7f-f095-486d-9c8c-eb324d3829d8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_cae6ba1e-f7b2-4467-a1b1-056fb9023c5a" xlink:to="loc_dei_EntitiesTable_feb21b7f-f095-486d-9c8c-eb324d3829d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_e8207d02-21d1-4d0b-856d-462e49f2ecf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_feb21b7f-f095-486d-9c8c-eb324d3829d8" xlink:to="loc_us-gaap_StatementClassOfStockAxis_e8207d02-21d1-4d0b-856d-462e49f2ecf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_e8207d02-21d1-4d0b-856d-462e49f2ecf7" xlink:to="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_c19ccc6b-7617-4999-b7fc-a72fa95cbb63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:to="loc_us-gaap_CommonStockMember_c19ccc6b-7617-4999-b7fc-a72fa95cbb63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_01c53497-7a72-4cb6-b3f3-16679d84308f" xlink:href="agnc-20220930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_01c53497-7a72-4cb6-b3f3-16679d84308f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_56923493-0731-4a4b-bf09-4f795b6c2c86" xlink:href="agnc-20220930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_56923493-0731-4a4b-bf09-4f795b6c2c86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_9626f47b-1e02-4c56-867f-3dae7c24f87a" xlink:href="agnc-20220930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_9626f47b-1e02-4c56-867f-3dae7c24f87a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_897e53f2-8481-43da-b793-0d6e6eeb61e2" xlink:href="agnc-20220930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_897e53f2-8481-43da-b793-0d6e6eeb61e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_d18c0afe-93b1-4f36-b2d8-7aa2eed4e29d" xlink:href="agnc-20220930.xsd#agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:to="loc_agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_d18c0afe-93b1-4f36-b2d8-7aa2eed4e29d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember_382697f1-3080-4cc2-a367-4a4acccabf79" xlink:href="agnc-20220930.xsd#agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_af795a13-3458-4964-941d-9d22fc32f51d" xlink:to="loc_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember_382697f1-3080-4cc2-a367-4a4acccabf79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_c41c36a3-998d-44aa-9c34-6ad80c0e98f2" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_feb21b7f-f095-486d-9c8c-eb324d3829d8" xlink:to="loc_dei_LegalEntityAxis_c41c36a3-998d-44aa-9c34-6ad80c0e98f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_64e8175d-4c74-45ec-9558-c19f064615a1" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_c41c36a3-998d-44aa-9c34-6ad80c0e98f2" xlink:to="loc_dei_EntityDomain_64e8175d-4c74-45ec-9558-c19f064615a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInformationLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_feb21b7f-f095-486d-9c8c-eb324d3829d8" xlink:to="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_fe0e2c50-0b22-443f-8beb-a4a230e5b34c" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_Security12bTitle_fe0e2c50-0b22-443f-8beb-a4a230e5b34c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_932fb30e-dc7b-45e4-82cf-d08db081ceaa" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityIncorporationStateCountryCode_932fb30e-dc7b-45e4-82cf-d08db081ceaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_93b85a50-0223-4200-bdab-ae4e3f7415f7" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_DocumentTransitionReport_93b85a50-0223-4200-bdab-ae4e3f7415f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_6ec27fee-0d9e-4fc4-92d8-8e067707f5c0" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_DocumentQuarterlyReport_6ec27fee-0d9e-4fc4-92d8-8e067707f5c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_5573e663-fb20-4619-85b3-18eef95c44c6" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityTaxIdentificationNumber_5573e663-fb20-4619-85b3-18eef95c44c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_a8c58342-76c1-406e-9cd9-a74651299f4f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentType"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_DocumentType_a8c58342-76c1-406e-9cd9-a74651299f4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_38e1e92d-7887-495e-8ded-add2794d4eed" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_AmendmentFlag_38e1e92d-7887-495e-8ded-add2794d4eed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_3bc61a1e-b8a4-468e-98ab-bea2e38d9817" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_DocumentPeriodEndDate_3bc61a1e-b8a4-468e-98ab-bea2e38d9817" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_f48ed445-9344-40ad-94ae-1a3bc42a0382" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityFileNumber_f48ed445-9344-40ad-94ae-1a3bc42a0382" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_625be543-e7d5-4c45-a198-50cbc5d1687f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_DocumentFiscalYearFocus_625be543-e7d5-4c45-a198-50cbc5d1687f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_051f2393-406b-487d-89b2-15b4630749ff" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_DocumentFiscalPeriodFocus_051f2393-406b-487d-89b2-15b4630749ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_abe723f2-9c99-42f3-bb31-5f23ba1b442d" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityRegistrantName_abe723f2-9c99-42f3-bb31-5f23ba1b442d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_b78e8292-1a46-4322-8ed2-98316d812dfd" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityAddressAddressLine1_b78e8292-1a46-4322-8ed2-98316d812dfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_82591753-7281-455b-b77b-f6cceb4a86f6" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityAddressCityOrTown_82591753-7281-455b-b77b-f6cceb4a86f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_3568c7ae-547a-475c-ab48-0d997519fe81" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityAddressStateOrProvince_3568c7ae-547a-475c-ab48-0d997519fe81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_514f223f-1e97-4afb-8737-cc756fc5b92c" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityAddressPostalZipCode_514f223f-1e97-4afb-8737-cc756fc5b92c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_85f878a9-3718-4bb2-a22e-934c3363d625" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_CityAreaCode_85f878a9-3718-4bb2-a22e-934c3363d625" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_27cb96c0-7f6b-4bad-8aed-2c4b53788705" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_LocalPhoneNumber_27cb96c0-7f6b-4bad-8aed-2c4b53788705" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_d64f52af-d0a0-4bba-a2a3-0ca5c3d5b1bb" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityCentralIndexKey_d64f52af-d0a0-4bba-a2a3-0ca5c3d5b1bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_dd6a50a5-4848-4adc-a91f-91fe89191b1d" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityFilerCategory_dd6a50a5-4848-4adc-a91f-91fe89191b1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_fe765740-d9c1-4244-940e-cbbd0a01a69f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntitySmallBusiness_fe765740-d9c1-4244-940e-cbbd0a01a69f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_b07d15d6-c750-4376-8be4-f9c6511fb00f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityEmergingGrowthCompany_b07d15d6-c750-4376-8be4-f9c6511fb00f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_be1072ea-67ab-4169-a97f-72d0a1954535" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_CurrentFiscalYearEndDate_be1072ea-67ab-4169-a97f-72d0a1954535" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_32e9f616-980e-40a2-aaef-7d0fec283a2b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_32e9f616-980e-40a2-aaef-7d0fec283a2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_7c3841d6-70f0-48cd-a652-f7bcf941a618" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_TradingSymbol_7c3841d6-70f0-48cd-a652-f7bcf941a618" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_74058de5-c75a-4cb2-aa0f-7eb888c604c7" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_SecurityExchangeName_74058de5-c75a-4cb2-aa0f-7eb888c604c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_0e5a4e1f-c227-419c-bcb5-09429b860c5a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_0e5a4e1f-c227-419c-bcb5-09429b860c5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers_f1f35a9f-803d-4af4-a492-aad8854eefe4" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityVoluntaryFilers"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityVoluntaryFilers_f1f35a9f-803d-4af4-a492-aad8854eefe4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_ddf46da1-c225-40bb-a7a0-4dfafc4a682f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityCurrentReportingStatus_ddf46da1-c225-40bb-a7a0-4dfafc4a682f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_4f2a6d7a-24fb-4d4f-9f7c-8a5e05424126" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityInteractiveDataCurrent_4f2a6d7a-24fb-4d4f-9f7c-8a5e05424126" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_6025c583-d121-4a2a-a45c-f57df506274a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="31" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_EntityShellCompany_6025c583-d121-4a2a-a45c-f57df506274a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_IcfrAuditorAttestationFlag_985d835a-d31f-48f9-99dc-86518f2d75f1" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_IcfrAuditorAttestationFlag"/>
    <link:presentationArc order="32" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_IcfrAuditorAttestationFlag_985d835a-d31f-48f9-99dc-86518f2d75f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AuditorFirmId_9060d453-39a3-4f7f-bca3-111ec7b319bf" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AuditorFirmId"/>
    <link:presentationArc order="33" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_AuditorFirmId_9060d453-39a3-4f7f-bca3-111ec7b319bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AuditorName_d4bdb1f4-0c64-4981-8274-49fe722b0b96" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AuditorName"/>
    <link:presentationArc order="34" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_AuditorName_d4bdb1f4-0c64-4981-8274-49fe722b0b96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AuditorLocation_621a8d46-5980-41b7-80d7-bd065e98f5c2" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AuditorLocation"/>
    <link:presentationArc order="35" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_181eb214-d97a-456c-b064-644559820406" xlink:to="loc_dei_AuditorLocation_621a8d46-5980-41b7-80d7-bd065e98f5c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="agnc-20220930.xsd#ConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_7e389e07-6efc-484e-8f0c-266ed8586eb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7e389e07-6efc-484e-8f0c-266ed8586eb7" xlink:to="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_dd53710c-72a1-48e9-adf2-a34f7c92407b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_dd53710c-72a1-48e9-adf2-a34f7c92407b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_56c1e3e9-393f-476b-ae9d-e07dad23e201" xlink:href="agnc-20220930.xsd#agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_56c1e3e9-393f-476b-ae9d-e07dad23e201" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_c7dea151-842a-461f-8797-bb2fdaa4b81f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_AssetsCurrent_c7dea151-842a-461f-8797-bb2fdaa4b81f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_39a1db74-5698-4db6-a11f-bb20995866c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_39a1db74-5698-4db6-a11f-bb20995866c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_30f93428-5e24-4a0c-941e-c5aff92e9f38" xlink:href="agnc-20220930.xsd#agnc_NonAgencySecuritiesatFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_30f93428-5e24-4a0c-941e-c5aff92e9f38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_b7a5d513-6afe-4f46-a8a6-a501c2565984" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_b7a5d513-6afe-4f46-a8a6-a501c2565984" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_69384eea-f256-49c7-b8aa-3864285979e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_69384eea-f256-49c7-b8aa-3864285979e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_9662d2f7-89a6-44d4-8941-7e1e8f6dcbd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_9662d2f7-89a6-44d4-8941-7e1e8f6dcbd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_f5554c55-988a-4184-9474-f39360b8d2d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_DerivativeAssets_f5554c55-988a-4184-9474-f39360b8d2d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_969dd6f1-628c-421f-80d3-a55cb74682df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_969dd6f1-628c-421f-80d3-a55cb74682df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_ff1b6626-3591-4699-aa84-9d9c6bbf751a" xlink:href="agnc-20220930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_ff1b6626-3591-4699-aa84-9d9c6bbf751a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_776b3e69-4b32-4108-9daa-5f8bfd95fa16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_776b3e69-4b32-4108-9daa-5f8bfd95fa16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_768e8727-e174-441e-bb8c-f828b5f74afd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssets"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_OtherAssets_768e8727-e174-441e-bb8c-f828b5f74afd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_bbf0fd13-8bab-4c6a-a281-cbb52d439139" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ce669a08-bd57-4b24-b780-4614e9b044cb" xlink:to="loc_us-gaap_Assets_bbf0fd13-8bab-4c6a-a281-cbb52d439139" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7e389e07-6efc-484e-8f0c-266ed8586eb7" xlink:to="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_c3307f7c-2793-41cf-8b9c-62b99c50ebb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_c3307f7c-2793-41cf-8b9c-62b99c50ebb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_e2a04010-7cbf-498e-8493-33c380e7d498" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLongTermDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:to="loc_us-gaap_OtherLongTermDebt_e2a04010-7cbf-498e-8493-33c380e7d498" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_627260b9-af31-4073-ba64-012abb8da8b8" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_PayablesToBrokerDealersAndClearingOrganizations"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:to="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_627260b9-af31-4073-ba64-012abb8da8b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_f7c583b7-3e50-4e32-ba25-fbdc574e7b4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:to="loc_us-gaap_DerivativeLiabilities_f7c583b7-3e50-4e32-ba25-fbdc574e7b4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_15e0eb60-28d2-45ff-b2c6-c6513eceedb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_15e0eb60-28d2-45ff-b2c6-c6513eceedb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_469b78fa-399b-420c-b935-9c138c113c4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:to="loc_us-gaap_OtherLiabilities_469b78fa-399b-420c-b935-9c138c113c4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_bd6a3f7b-f2ce-4336-8eee-401a3c7d32a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_31a08328-f2bb-4a07-bba9-51732983ed5a" xlink:to="loc_us-gaap_Liabilities_bd6a3f7b-f2ce-4336-8eee-401a3c7d32a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7e389e07-6efc-484e-8f0c-266ed8586eb7" xlink:to="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_09c3a061-9fc5-4c81-b61e-7c6b28afe15d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:to="loc_us-gaap_PreferredStockValue_09c3a061-9fc5-4c81-b61e-7c6b28afe15d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_20e59de0-308e-46cf-ad44-fb396beeb4b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:to="loc_us-gaap_CommonStockValue_20e59de0-308e-46cf-ad44-fb396beeb4b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_b2dcd6ad-095b-4e9c-833a-8cb398ec8125" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:to="loc_us-gaap_AdditionalPaidInCapital_b2dcd6ad-095b-4e9c-833a-8cb398ec8125" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_8c135cdd-07a0-4912-8712-e698f3280b16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_8c135cdd-07a0-4912-8712-e698f3280b16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_e2d6c494-0d06-44f8-978b-c4ce3d845d7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_e2d6c494-0d06-44f8-978b-c4ce3d845d7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d90372b6-bd7f-46fe-bba5-db53357deaee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9fc3b7cb-f785-42f6-b145-4dfbbc63aca7" xlink:to="loc_us-gaap_StockholdersEquity_d90372b6-bd7f-46fe-bba5-db53357deaee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_54fc8936-18e3-4536-8944-af91b5388345" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7e389e07-6efc-484e-8f0c-266ed8586eb7" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_54fc8936-18e3-4536-8944-af91b5388345" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_068500f7-4b4a-407e-ab92-70ddae2f7e55" xlink:href="agnc-20220930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7e389e07-6efc-484e-8f0c-266ed8586eb7" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_068500f7-4b4a-407e-ab92-70ddae2f7e55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="agnc-20220930.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ConsolidatedBalanceSheetsParentheticalAbstract_243b394f-47d8-4673-9eaa-8d40e0ef14f1" xlink:href="agnc-20220930.xsd#agnc_ConsolidatedBalanceSheetsParentheticalAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_56d809dd-879e-4772-80c8-57c55d5f7822" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ConsolidatedBalanceSheetsParentheticalAbstract_243b394f-47d8-4673-9eaa-8d40e0ef14f1" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_56d809dd-879e-4772-80c8-57c55d5f7822" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_69a81d85-abd9-4a46-80f8-59dac6692552" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_56d809dd-879e-4772-80c8-57c55d5f7822" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_69a81d85-abd9-4a46-80f8-59dac6692552" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_686b4b31-eddd-4e7b-929a-f0cacaf1214c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_69a81d85-abd9-4a46-80f8-59dac6692552" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_686b4b31-eddd-4e7b-929a-f0cacaf1214c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetPledgedAsCollateralMember_bacb4899-bba3-4447-9619-b6c2078db3aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetPledgedAsCollateralMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_686b4b31-eddd-4e7b-929a-f0cacaf1214c" xlink:to="loc_us-gaap_AssetPledgedAsCollateralMember_bacb4899-bba3-4447-9619-b6c2078db3aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_19c3a80b-3e92-4901-aaf5-297147ade58e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_56d809dd-879e-4772-80c8-57c55d5f7822" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_19c3a80b-3e92-4901-aaf5-297147ade58e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_1e121373-4669-4689-b6e9-0ffbee8e95b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_19c3a80b-3e92-4901-aaf5-297147ade58e" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_1e121373-4669-4689-b6e9-0ffbee8e95b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AgencySecuritiesMember_8935e799-d960-4670-8d3b-171b9cd628b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AgencySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_1e121373-4669-4689-b6e9-0ffbee8e95b1" xlink:to="loc_us-gaap_AgencySecuritiesMember_8935e799-d960-4670-8d3b-171b9cd628b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_ddc31961-2937-461d-9d9c-c85b70d8ba91" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_1e121373-4669-4689-b6e9-0ffbee8e95b1" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_ddc31961-2937-461d-9d9c-c85b70d8ba91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_b3a11acc-ba37-4715-87e3-06edbac92919" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_1e121373-4669-4689-b6e9-0ffbee8e95b1" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_b3a11acc-ba37-4715-87e3-06edbac92919" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_07754f66-9b23-48db-82ba-d4b55979862e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_1e121373-4669-4689-b6e9-0ffbee8e95b1" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_07754f66-9b23-48db-82ba-d4b55979862e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableforsecuritiessoldMember_e805edd7-641e-496a-867a-2eeda458a03d" xlink:href="agnc-20220930.xsd#agnc_ReceivableforsecuritiessoldMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_1e121373-4669-4689-b6e9-0ffbee8e95b1" xlink:to="loc_agnc_ReceivableforsecuritiessoldMember_e805edd7-641e-496a-867a-2eeda458a03d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_9e541943-aad5-49b1-98cd-6fc17c2b6419" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_56d809dd-879e-4772-80c8-57c55d5f7822" xlink:to="loc_us-gaap_StatementClassOfStockAxis_9e541943-aad5-49b1-98cd-6fc17c2b6419" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_4f0c6eeb-8154-4d6b-9a83-46a072c95e96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_9e541943-aad5-49b1-98cd-6fc17c2b6419" xlink:to="loc_us-gaap_ClassOfStockDomain_4f0c6eeb-8154-4d6b-9a83-46a072c95e96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_08647ebb-2edf-4074-ab3a-64df37cc14cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4f0c6eeb-8154-4d6b-9a83-46a072c95e96" xlink:to="loc_us-gaap_CommonStockMember_08647ebb-2edf-4074-ab3a-64df37cc14cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_66c72d92-f49e-4dfa-a005-ec443af7dbbf" xlink:href="agnc-20220930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4f0c6eeb-8154-4d6b-9a83-46a072c95e96" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_66c72d92-f49e-4dfa-a005-ec443af7dbbf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_c67aae9e-6301-4690-8c8a-7e55982f19ae" xlink:href="agnc-20220930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4f0c6eeb-8154-4d6b-9a83-46a072c95e96" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_c67aae9e-6301-4690-8c8a-7e55982f19ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_95944cf7-3b6d-4c57-9661-f5dc08abc56b" xlink:href="agnc-20220930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4f0c6eeb-8154-4d6b-9a83-46a072c95e96" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_95944cf7-3b6d-4c57-9661-f5dc08abc56b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_46124dd1-4e71-49ad-bb84-a873072aaa23" xlink:href="agnc-20220930.xsd#agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4f0c6eeb-8154-4d6b-9a83-46a072c95e96" xlink:to="loc_agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_46124dd1-4e71-49ad-bb84-a873072aaa23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_56d809dd-879e-4772-80c8-57c55d5f7822" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_3e9f47e3-22d5-4da4-b30a-87b2b961d768" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_3e9f47e3-22d5-4da4-b30a-87b2b961d768" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedSecuritiesPledged_848baabe-5587-4695-976a-98c8598586c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedSecuritiesPledged"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedSecuritiesPledged_848baabe-5587-4695-976a-98c8598586c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue_d44097ae-6214-43f2-83c5-1123ebb29253" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_DebtInstrumentFairValue_d44097ae-6214-43f2-83c5-1123ebb29253" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_cc711faf-19aa-4330-803a-f55be51f35dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_cc711faf-19aa-4330-803a-f55be51f35dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue_0346b1e2-1b91-4159-881b-67dc72a38bdd" xlink:href="agnc-20220930.xsd#agnc_PreferredStockBLiquidationPreferenceValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_agnc_PreferredStockBLiquidationPreferenceValue_0346b1e2-1b91-4159-881b-67dc72a38bdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_5bb52166-3e7e-4a38-9c10-d0259a072f41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_5bb52166-3e7e-4a38-9c10-d0259a072f41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue_ba115f9d-a861-458b-a8a0-5d5f440857b5" xlink:href="agnc-20220930.xsd#agnc_PreferredStockCLiquidationPreferenceValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_agnc_PreferredStockCLiquidationPreferenceValue_ba115f9d-a861-458b-a8a0-5d5f440857b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDLiquidationPreferenceValue_aec6570e-32f9-4cea-a35f-68b93aee7046" xlink:href="agnc-20220930.xsd#agnc_PreferredStockDLiquidationPreferenceValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_agnc_PreferredStockDLiquidationPreferenceValue_aec6570e-32f9-4cea-a35f-68b93aee7046" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_722180c1-30b4-4b30-b978-042fb1f0f341" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_722180c1-30b4-4b30-b978-042fb1f0f341" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_f824ce63-b809-40bf-b014-76f75f90fba7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_f824ce63-b809-40bf-b014-76f75f90fba7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_2f4f9f33-f4c3-445b-89c9-7ba1b5c81f3b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_CommonStockSharesIssued_2f4f9f33-f4c3-445b-89c9-7ba1b5c81f3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_b245d1fc-9b29-439b-aa9b-8da5e07d6c22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_b245d1fc-9b29-439b-aa9b-8da5e07d6c22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_945a5c55-d197-4388-b884-d43e5f5bd57a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_dei_Security12bTitle_945a5c55-d197-4388-b884-d43e5f5bd57a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedFinancialInstrumentsSecurities_77ef3671-f501-4296-bcc5-16f13d6afd06" xlink:href="agnc-20220930.xsd#agnc_PledgedFinancialInstrumentsSecurities"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_0500d420-e646-4f28-b184-46bef328e7f4" xlink:to="loc_agnc_PledgedFinancialInstrumentsSecurities_77ef3671-f501-4296-bcc5-16f13d6afd06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" xlink:href="agnc-20220930.xsd#ConsolidatedStatementsOfComprehensiveIncome"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_60111a9a-f092-4982-a476-d64c452f2a97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_StatementTable_60111a9a-f092-4982-a476-d64c452f2a97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_4afa2059-a524-4705-846b-9e399ee060bc" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_60111a9a-f092-4982-a476-d64c452f2a97" xlink:to="loc_srt_StatementScenarioAxis_4afa2059-a524-4705-846b-9e399ee060bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_c0070be9-9110-4b74-a1fc-09a0963e2732" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementScenarioAxis_4afa2059-a524-4705-846b-9e399ee060bc" xlink:to="loc_srt_ScenarioUnspecifiedDomain_c0070be9-9110-4b74-a1fc-09a0963e2732" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_60111a9a-f092-4982-a476-d64c452f2a97" xlink:to="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_1ed1fe9e-6e57-4a57-9523-5a706130b644" xlink:href="agnc-20220930.xsd#agnc_Issuancecostsofredeemedpreferredstock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_1ed1fe9e-6e57-4a57-9523-5a706130b644" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_5ced5921-6bdf-47ae-86c2-fa1ad705a1cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_5ced5921-6bdf-47ae-86c2-fa1ad705a1cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_2a76bc3f-3df9-4cdb-83d2-0690bb526077" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_2a76bc3f-3df9-4cdb-83d2-0690bb526077" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_097ea373-358d-4e05-8829-daf1599622a2" xlink:href="agnc-20220930.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_097ea373-358d-4e05-8829-daf1599622a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_60512553-9ee0-4e0e-ae7a-37665e19ee33" xlink:href="agnc-20220930.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_60512553-9ee0-4e0e-ae7a-37665e19ee33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ManagementFeeIncome_f9c06afa-33f0-4b23-98bf-6e4456b19c2c" xlink:href="agnc-20220930.xsd#agnc_ManagementFeeIncome"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_agnc_ManagementFeeIncome_f9c06afa-33f0-4b23-98bf-6e4456b19c2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_cb459fb2-525c-40fc-8851-323b15f59623" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_cb459fb2-525c-40fc-8851-323b15f59623" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_e28a907a-d8fc-46d5-a05f-0c396ff953eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_e28a907a-d8fc-46d5-a05f-0c396ff953eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_6302ab49-1e61-47b4-a944-d68ce485fc1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_InterestExpense_6302ab49-1e61-47b4-a944-d68ce485fc1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_14b57548-0228-4f64-baae-97c06a6c87c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_14b57548-0228-4f64-baae-97c06a6c87c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_c355600b-0353-46fa-aaff-7271eeebf908" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_LaborAndRelatedExpense_c355600b-0353-46fa-aaff-7271eeebf908" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_326b4d84-e741-4411-b131-c10b43194625" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_326b4d84-e741-4411-b131-c10b43194625" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_c5d68a51-b561-4870-b009-2accd6615e0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_OperatingExpenses_c5d68a51-b561-4870-b009-2accd6615e0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_310d4930-06ee-4ff7-b65c-54bc9d918572" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_NetIncomeLoss_310d4930-06ee-4ff7-b65c-54bc9d918572" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_683d1f6d-1c4a-4462-9215-c73d0f7a174a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_683d1f6d-1c4a-4462-9215-c73d0f7a174a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_9bfac974-730b-4da9-9e02-71806b7ab612" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_9bfac974-730b-4da9-9e02-71806b7ab612" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_83137c65-ed61-4f06-8463-bf4e0577f18e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_83137c65-ed61-4f06-8463-bf4e0577f18e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_84d2f6e6-bfd4-49c2-99c7-3c43e8278bd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_84d2f6e6-bfd4-49c2-99c7-3c43e8278bd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_c1c43153-6e69-4666-af85-ebb2a9c686b1" xlink:href="agnc-20220930.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_c1c43153-6e69-4666-af85-ebb2a9c686b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_4b898513-262c-4134-b023-425273fe0d91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_4b898513-262c-4134-b023-425273fe0d91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_0032a778-3987-4d23-8070-9a3c291373b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_0032a778-3987-4d23-8070-9a3c291373b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_359fccac-190e-4273-91b5-3699eeff8bf2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_EarningsPerShareBasic_359fccac-190e-4273-91b5-3699eeff8bf2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_0c843e8e-0169-485f-ae4f-b29f9ee4cace" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_69dacc8a-bc45-471e-9600-98bbfd794dd4" xlink:to="loc_us-gaap_EarningsPerShareDiluted_0c843e8e-0169-485f-ae4f-b29f9ee4cace" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNetAbstract_c88125c3-1c1e-41a9-832e-c1b01507c8a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNetAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_InterestIncomeExpenseNetAbstract_c88125c3-1c1e-41a9-832e-c1b01507c8a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_9002b2c6-98aa-4e02-8675-22819d8f3abf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_c88125c3-1c1e-41a9-832e-c1b01507c8a9" xlink:to="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_9002b2c6-98aa-4e02-8675-22819d8f3abf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_6e9947ed-4dd2-4e62-9664-e400e79fdd4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_c88125c3-1c1e-41a9-832e-c1b01507c8a9" xlink:to="loc_us-gaap_InterestExpense_6e9947ed-4dd2-4e62-9664-e400e79fdd4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_929c19a7-63df-4bdc-91d3-fb73d81fce7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_c88125c3-1c1e-41a9-832e-c1b01507c8a9" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_929c19a7-63df-4bdc-91d3-fb73d81fce7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeAbstract_743ed6ee-a238-47ba-bd24-adfb0cfa3067" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncomeAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_NoninterestIncomeAbstract_743ed6ee-a238-47ba-bd24-adfb0cfa3067" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_46dd1b92-661a-483d-80c8-f35d20bbbfe6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_743ed6ee-a238-47ba-bd24-adfb0cfa3067" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_46dd1b92-661a-483d-80c8-f35d20bbbfe6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_4888c90e-133b-4026-9e07-3f56296e72e9" xlink:href="agnc-20220930.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_743ed6ee-a238-47ba-bd24-adfb0cfa3067" xlink:to="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_4888c90e-133b-4026-9e07-3f56296e72e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_3956dc42-bd8c-484b-b236-06f0f5fb201d" xlink:href="agnc-20220930.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_743ed6ee-a238-47ba-bd24-adfb0cfa3067" xlink:to="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_3956dc42-bd8c-484b-b236-06f0f5fb201d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpenseAbstract_22edd07a-03e0-4246-8ec2-59d7e08a9331" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpenseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_NoninterestExpenseAbstract_22edd07a-03e0-4246-8ec2-59d7e08a9331" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_3ec81745-7b61-41d4-b30c-6986a5452103" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_22edd07a-03e0-4246-8ec2-59d7e08a9331" xlink:to="loc_us-gaap_LaborAndRelatedExpense_3ec81745-7b61-41d4-b30c-6986a5452103" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_770479b3-f70f-45da-b03c-46f66e1e9458" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_22edd07a-03e0-4246-8ec2-59d7e08a9331" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_770479b3-f70f-45da-b03c-46f66e1e9458" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_f1da7f7a-8343-4ad9-9ef0-a5ceda204382" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_22edd07a-03e0-4246-8ec2-59d7e08a9331" xlink:to="loc_us-gaap_OperatingExpenses_f1da7f7a-8343-4ad9-9ef0-a5ceda204382" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b26c6b16-a1fc-4d13-9797-9b1b7c7eb010" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_NetIncomeLoss_b26c6b16-a1fc-4d13-9797-9b1b7c7eb010" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_ecbd25da-02e3-4361-95b2-562f731814b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_ecbd25da-02e3-4361-95b2-562f731814b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_a9c27d29-a9af-44a2-91ee-bff9f5c72f78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_a9c27d29-a9af-44a2-91ee-bff9f5c72f78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1c68b913-e505-49c7-aafd-2ce971ea18ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1c68b913-e505-49c7-aafd-2ce971ea18ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_5021bbb8-6286-452a-a969-2d80a87839a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1c68b913-e505-49c7-aafd-2ce971ea18ea" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_5021bbb8-6286-452a-a969-2d80a87839a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_d1bc0dbf-0181-4239-8583-9e58facf89e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_d1bc0dbf-0181-4239-8583-9e58facf89e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_531d4317-b899-4bf6-92a6-7bbda10d3023" xlink:href="agnc-20220930.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_531d4317-b899-4bf6-92a6-7bbda10d3023" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_00434058-c52b-4fc2-8739-ecfefd11b05a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_00434058-c52b-4fc2-8739-ecfefd11b05a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_9efe7baa-6d2b-40cb-adf7-1180713e61ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_9efe7baa-6d2b-40cb-adf7-1180713e61ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_951f8b44-384a-411f-a3d3-d519f6862a07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_EarningsPerShareBasic_951f8b44-384a-411f-a3d3-d519f6862a07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_39270e56-36a5-4a84-b9ef-6805d359033c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_abff44c3-ad4e-4ce0-acc5-5ef64106d988" xlink:to="loc_us-gaap_EarningsPerShareDiluted_39270e56-36a5-4a84-b9ef-6805d359033c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="simple" xlink:href="agnc-20220930.xsd#ConsolidatedStatementofStockholdersEquity"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_416b0f91-d777-489b-8633-e2479a7ac5f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_57bdd103-9a19-41e8-81fc-fce3c3cd3355" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_416b0f91-d777-489b-8633-e2479a7ac5f3" xlink:to="loc_us-gaap_StatementTable_57bdd103-9a19-41e8-81fc-fce3c3cd3355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_8618922e-a51e-4865-8e6e-a8dfd48ccdd5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_57bdd103-9a19-41e8-81fc-fce3c3cd3355" xlink:to="loc_us-gaap_StatementClassOfStockAxis_8618922e-a51e-4865-8e6e-a8dfd48ccdd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c8140205-0992-4763-b578-a16acc87b94b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8618922e-a51e-4865-8e6e-a8dfd48ccdd5" xlink:to="loc_us-gaap_ClassOfStockDomain_c8140205-0992-4763-b578-a16acc87b94b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_7683a169-4a43-4fff-b2ff-4558a57bf7c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c8140205-0992-4763-b578-a16acc87b94b" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_7683a169-4a43-4fff-b2ff-4558a57bf7c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_ae3a6005-dd73-4beb-8ccb-ce5370301811" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesBPreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c8140205-0992-4763-b578-a16acc87b94b" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_ae3a6005-dd73-4beb-8ccb-ce5370301811" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_32f72aa5-00c2-4404-9fed-4341047c23db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesCPreferredStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c8140205-0992-4763-b578-a16acc87b94b" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_32f72aa5-00c2-4404-9fed-4341047c23db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_1864e2f8-57fb-4ff9-ac23-7b525183375c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesDPreferredStockMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c8140205-0992-4763-b578-a16acc87b94b" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_1864e2f8-57fb-4ff9-ac23-7b525183375c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_b11ea336-0a79-4327-826b-1d65c54f02fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_57bdd103-9a19-41e8-81fc-fce3c3cd3355" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_b11ea336-0a79-4327-826b-1d65c54f02fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_24b6abe8-c317-42cf-8f54-56f0e8616778" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_b11ea336-0a79-4327-826b-1d65c54f02fb" xlink:to="loc_us-gaap_EquityComponentDomain_24b6abe8-c317-42cf-8f54-56f0e8616778" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockMember_980ea674-5563-42af-9370-85e29a8501c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_24b6abe8-c317-42cf-8f54-56f0e8616778" xlink:to="loc_us-gaap_PreferredStockMember_980ea674-5563-42af-9370-85e29a8501c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_21d271d7-2dbb-4237-9d9b-a92e40626398" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_24b6abe8-c317-42cf-8f54-56f0e8616778" xlink:to="loc_us-gaap_CommonStockMember_21d271d7-2dbb-4237-9d9b-a92e40626398" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_5ab53919-804f-4847-b488-75581df2ed23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_24b6abe8-c317-42cf-8f54-56f0e8616778" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_5ab53919-804f-4847-b488-75581df2ed23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_7625cfb3-c396-4e0b-b186-c924e9d6727f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_24b6abe8-c317-42cf-8f54-56f0e8616778" xlink:to="loc_us-gaap_RetainedEarningsMember_7625cfb3-c396-4e0b-b186-c924e9d6727f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_0880b31f-5bef-45bf-8c39-7ae66ae4feff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_24b6abe8-c317-42cf-8f54-56f0e8616778" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_0880b31f-5bef-45bf-8c39-7ae66ae4feff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_57bdd103-9a19-41e8-81fc-fce3c3cd3355" xlink:to="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_02731937-5508-41f8-8982-2694f5b706b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockholdersEquity_02731937-5508-41f8-8982-2694f5b706b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_6154bf9e-1601-48e4-a3ec-14c487914e30" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_6154bf9e-1601-48e4-a3ec-14c487914e30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3f3966a8-216d-408a-a091-192539a5cb5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_NetIncomeLoss_3f3966a8-216d-408a-a091-192539a5cb5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_f89d521a-cc92-4ecb-a108-c3606ebf2adb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_f89d521a-cc92-4ecb-a108-c3606ebf2adb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_360b9e29-58bc-45d9-b6f2-f74d17cd2231" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_f89d521a-cc92-4ecb-a108-c3606ebf2adb" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_360b9e29-58bc-45d9-b6f2-f74d17cd2231" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_e96a2ade-371a-4fa4-83bc-0e9afea80bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_f89d521a-cc92-4ecb-a108-c3606ebf2adb" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_e96a2ade-371a-4fa4-83bc-0e9afea80bf8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_abb746a0-5961-4ecd-9b83-f4671cc8fc0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_abb746a0-5961-4ecd-9b83-f4671cc8fc0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_f4aa726b-4166-4343-99bf-4e91f4db1c01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_f4aa726b-4166-4343-99bf-4e91f4db1c01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_ce61a78e-8c1b-4698-9d77-ccace1e1bdb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_ce61a78e-8c1b-4698-9d77-ccace1e1bdb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_3f1d3c0d-4d51-4e3c-bd09-a40595899660" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_3f1d3c0d-4d51-4e3c-bd09-a40595899660" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_3bad99ca-9d4b-49f1-b9eb-4644a7e3ba06" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_3bad99ca-9d4b-49f1-b9eb-4644a7e3ba06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_1f961b32-9dbb-4e20-84c1-29e70bf18e13" xlink:href="agnc-20220930.xsd#agnc_Issuancecostsofredeemedpreferredstock"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_1f961b32-9dbb-4e20-84c1-29e70bf18e13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_d1700e36-0b56-4f71-a986-bb8b89ced736" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_d1700e36-0b56-4f71-a986-bb8b89ced736" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_a210d650-0403-4f5e-8aa4-b4e2416ccf58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_a210d650-0403-4f5e-8aa4-b4e2416ccf58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_ef45ab51-1dd6-4b92-9993-c4e36fbcac0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_ef45ab51-1dd6-4b92-9993-c4e36fbcac0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_681d086e-4935-47b0-9495-1bda91fbb492" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_681d086e-4935-47b0-9495-1bda91fbb492" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPreferredStockCash_135fb841-4af0-49fc-8191-c076317f82ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPreferredStockCash"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_DividendsPreferredStockCash_135fb841-4af0-49fc-8191-c076317f82ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_47ace2dc-1673-47e6-bb19-79083fea8ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_DividendsCommonStockCash_47ace2dc-1673-47e6-bb19-79083fea8ce6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_22197593-71b7-4813-b324-f98ebcd17719" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_StockholdersEquity_22197593-71b7-4813-b324-f98ebcd17719" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_a215d394-c0fb-4c87-a119-574b38562cd7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_54268af6-2e80-4135-9cac-6c1e358222b7" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_a215d394-c0fb-4c87-a119-574b38562cd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="agnc-20220930.xsd#ConsolidatedStatementsOfCashFlows"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_806380c5-b1c0-49b9-8b39-8bfc390757cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_806380c5-b1c0-49b9-8b39-8bfc390757cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaid_94ac7f06-5bca-4465-bbe6-066cd2748374" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestPaid"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_InterestPaid_94ac7f06-5bca-4465-bbe6-066cd2748374" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_c370434a-bbd0-4d0c-a217-27f6a7cead5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_c370434a-bbd0-4d0c-a217-27f6a7cead5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8c37c11e-35b2-4a10-9831-3f2c437a4824" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_c370434a-bbd0-4d0c-a217-27f6a7cead5a" xlink:to="loc_us-gaap_NetIncomeLoss_8c37c11e-35b2-4a10-9831-3f2c437a4824" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_c370434a-bbd0-4d0c-a217-27f6a7cead5a" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_6bd261b5-27bf-4a67-8e68-2345cbc6683e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_6bd261b5-27bf-4a67-8e68-2345cbc6683e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_7749e088-6cd1-4496-9816-16c73e5e5f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_7749e088-6cd1-4496-9816-16c73e5e5f5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_231a47e0-ca95-478f-a313-078d23339d12" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_us-gaap_ShareBasedCompensation_231a47e0-ca95-478f-a313-078d23339d12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_9e97c863-1709-40a5-8e0a-de1f5de98dc1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_9e97c863-1709-40a5-8e0a-de1f5de98dc1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_dfdc1b85-d9ae-48b9-aca8-ee06fec1f74b" xlink:href="agnc-20220930.xsd#agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_dfdc1b85-d9ae-48b9-aca8-ee06fec1f74b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_9923f3f6-25f4-4698-98fd-bcdf6065d648" xlink:href="agnc-20220930.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_9923f3f6-25f4-4698-98fd-bcdf6065d648" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_cb21c054-bfac-4e79-9261-3a122106cf0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_cb21c054-bfac-4e79-9261-3a122106cf0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_a83e947a-d974-4b8c-aa61-81fd2f373d07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_a83e947a-d974-4b8c-aa61-81fd2f373d07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4972e06-f67d-4c94-b976-24fefab14831" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a9e43b9d-a6d8-4289-a265-e3272f06e804" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4972e06-f67d-4c94-b976-24fefab14831" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_72ed8b12-3b44-4eda-921a-bcc9f4441095" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_72ed8b12-3b44-4eda-921a-bcc9f4441095" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_ce93967d-a035-4277-bf00-f641dc7ac185" xlink:href="agnc-20220930.xsd#agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_ce93967d-a035-4277-bf00-f641dc7ac185" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_81fdf3f4-53c2-4c27-acbf-30a4e7ae8063" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_81fdf3f4-53c2-4c27-acbf-30a4e7ae8063" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_93807378-3939-4822-8ddb-9fe3e98f9cc9" xlink:href="agnc-20220930.xsd#agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_93807378-3939-4822-8ddb-9fe3e98f9cc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_0c12ee39-0ef7-43ca-ae75-249cc079593c" xlink:href="agnc-20220930.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_0c12ee39-0ef7-43ca-ae75-249cc079593c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_8b5c5ac5-01a6-46e5-ba31-d0fd3a14ce77" xlink:href="agnc-20220930.xsd#agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_8b5c5ac5-01a6-46e5-ba31-d0fd3a14ce77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PaymentsToAcquireUSTreasurySecurities_cea1703f-b12b-4440-a212-9d4b50b9b911" xlink:href="agnc-20220930.xsd#agnc_PaymentsToAcquireUSTreasurySecurities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_agnc_PaymentsToAcquireUSTreasurySecurities_cea1703f-b12b-4440-a212-9d4b50b9b911" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsFromSaleOfUSTreasurySecurities_2ca6df9b-3a28-4bc5-982e-f557ced157cf" xlink:href="agnc-20220930.xsd#agnc_ProceedsFromSaleOfUSTreasurySecurities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_agnc_ProceedsFromSaleOfUSTreasurySecurities_2ca6df9b-3a28-4bc5-982e-f557ced157cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_d66a6bd4-c007-44d5-9e9f-1d0fb744c785" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_d66a6bd4-c007-44d5-9e9f-1d0fb744c785" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_047b5018-2f5f-4172-ab6a-709b66ef48dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_047b5018-2f5f-4172-ab6a-709b66ef48dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_bc6630bd-4dab-4ad6-a3ad-654d95811694" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_95954245-1882-4c84-919a-881de9481f95" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_bc6630bd-4dab-4ad6-a3ad-654d95811694" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_859ba785-8526-4e7c-99a0-640902e2d624" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromShortTermDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_859ba785-8526-4e7c-99a0-640902e2d624" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_b4a5cdf6-93a4-48bc-b9a2-6594889f2891" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfShortTermDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_b4a5cdf6-93a4-48bc-b9a2-6594889f2891" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_d9940bdd-11a1-47ab-8c28-2adf7c02c6d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfOtherDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_d9940bdd-11a1-47ab-8c28-2adf7c02c6d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_75fcd1b1-bd6b-4c30-9fc4-99deb6f7351a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_75fcd1b1-bd6b-4c30-9fc4-99deb6f7351a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_05077131-f1c8-4b1e-94ed-c05f13b174ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_05077131-f1c8-4b1e-94ed-c05f13b174ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_56504260-433f-486d-880e-fb68dcf8fdff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_56504260-433f-486d-880e-fb68dcf8fdff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_8a33f822-7567-4ac2-8cbd-4f6d48d59967" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_8a33f822-7567-4ac2-8cbd-4f6d48d59967" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_f3d35e8e-4c30-4cdc-afa4-d045c9d27c7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_f3d35e8e-4c30-4cdc-afa4-d045c9d27c7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_3e8b9a20-f273-436c-80b6-42944f85e21a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividends"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_PaymentsOfDividends_3e8b9a20-f273-436c-80b6-42944f85e21a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_dd857adc-d156-43c3-a0f3-9eb7cfef45f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_92ba1def-df59-4632-a22f-ee309c1498cd" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_dd857adc-d156-43c3-a0f3-9eb7cfef45f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_7bab8c33-56af-48e1-9a55-421c9fc2da5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_7bab8c33-56af-48e1-9a55-421c9fc2da5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_10ea64bb-4776-4c5b-ada1-287d62e9107a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_10ea64bb-4776-4c5b-ada1-287d62e9107a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_3531afd4-a380-4335-9f6f-47d5180cb713" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_3531afd4-a380-4335-9f6f-47d5180cb713" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaid_caf96d27-14c6-4cde-8a75-68ffe0e1bf43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxesPaid"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_3531afd4-a380-4335-9f6f-47d5180cb713" xlink:to="loc_us-gaap_IncomeTaxesPaid_caf96d27-14c6-4cde-8a75-68ffe0e1bf43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_e313924d-e576-48f8-8536-a48843d3910d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_46913819-db9b-4c61-a33f-60128ee38024" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_e313924d-e576-48f8-8536-a48843d3910d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/Organization" xlink:type="simple" xlink:href="agnc-20220930.xsd#Organization"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/Organization" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_357ee54d-f1e4-4ca2-9ec0-447ab752e60f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_11a005fe-9c2f-4ff2-af80-6a467d6be7b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_357ee54d-f1e4-4ca2-9ec0-447ab752e60f" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_11a005fe-9c2f-4ff2-af80-6a467d6be7b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="agnc-20220930.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_995a9195-7c72-4651-9a50-ded488a8a4e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_dea0089a-c363-4404-9562-dd202f762c61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_995a9195-7c72-4651-9a50-ded488a8a4e8" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_dea0089a-c363-4404-9562-dd202f762c61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccounting_597856ec-2a0e-49b8-bfa6-56d329f2398a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BasisOfAccounting"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_995a9195-7c72-4651-9a50-ded488a8a4e8" xlink:to="loc_us-gaap_BasisOfAccounting_597856ec-2a0e-49b8-bfa6-56d329f2398a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_1339fbc7-7f1b-4b44-8aad-797e9655c409" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_995a9195-7c72-4651-9a50-ded488a8a4e8" xlink:to="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_1339fbc7-7f1b-4b44-8aad-797e9655c409" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_523a566f-e6dc-4eb9-b8b9-1bea032520c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_995a9195-7c72-4651-9a50-ded488a8a4e8" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_523a566f-e6dc-4eb9-b8b9-1bea032520c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecurities" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecurities"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecurities" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_bfa38475-3abe-4d56-8483-7e3e14d32440" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_61699936-cc47-4b80-9653-b3d0c4716c2f" xlink:href="agnc-20220930.xsd#agnc_InvestmentInMortgageBackedSecuritiesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_bfa38475-3abe-4d56-8483-7e3e14d32440" xlink:to="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_61699936-cc47-4b80-9653-b3d0c4716c2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="simple" xlink:href="agnc-20220930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreements"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_dacaabc0-c7f4-4116-a364-b204f63b3848" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_30a1ad6b-a630-44bd-bdac-5c71037e9c01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_dacaabc0-c7f4-4116-a364-b204f63b3848" xlink:to="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_30a1ad6b-a630-44bd-bdac-5c71037e9c01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstruments" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstruments"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstruments" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_67065041-84f4-4433-af28-8be6889cf49e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_442e8817-1296-4896-8ba7-55f1e727c1ef" xlink:href="agnc-20220930.xsd#agnc_USGovernmentFuturesSecuritiesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_67065041-84f4-4433-af28-8be6889cf49e" xlink:to="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_442e8817-1296-4896-8ba7-55f1e727c1ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_a354ac8f-4b61-4719-b86d-49b80ce3da20" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_67065041-84f4-4433-af28-8be6889cf49e" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_a354ac8f-4b61-4719-b86d-49b80ce3da20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/BalanceSheetOffsetting" xlink:type="simple" xlink:href="agnc-20220930.xsd#BalanceSheetOffsetting"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/BalanceSheetOffsetting" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_da19b180-c10f-4abf-a5c9-6cca09654938" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsAndOtherLiabilitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsAndOtherLiabilitiesDisclosureTextBlock_905f87fd-ac92-4093-9ce6-c92aeeff8ee0" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsAndOtherLiabilitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_da19b180-c10f-4abf-a5c9-6cca09654938" xlink:to="loc_agnc_OtherAssetsAndOtherLiabilitiesDisclosureTextBlock_905f87fd-ac92-4093-9ce6-c92aeeff8ee0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssets" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssets"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_2c94db36-267a-4dd9-a3f7-e04599273548" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsTextBlock_4244760b-2015-404a-875b-6aa83a4d007e" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_2c94db36-267a-4dd9-a3f7-e04599273548" xlink:to="loc_agnc_PledgedAssetsTextBlock_4244760b-2015-404a-875b-6aa83a4d007e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="agnc-20220930.xsd#FairValueMeasurements"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_8d8702c4-060f-4ba4-9c4e-cbd7c7f6d4b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_bf9b5f94-575a-48b1-80e1-e44644cd0ceb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_8d8702c4-060f-4ba4-9c4e-cbd7c7f6d4b7" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_bf9b5f94-575a-48b1-80e1-e44644cd0ceb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:type="simple" xlink:href="agnc-20220930.xsd#NetIncomeLossPerCommonShareNotes"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NetIncomeLossPerCommonShareAbstract_36898f12-05c9-4528-b237-76ef42ea2185" xlink:href="agnc-20220930.xsd#agnc_NetIncomeLossPerCommonShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_9c56b9d9-f84a-494f-b504-9712047cc3c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_36898f12-05c9-4528-b237-76ef42ea2185" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_9c56b9d9-f84a-494f-b504-9712047cc3c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_23c4def7-3495-4079-912b-fb422828951e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_36898f12-05c9-4528-b237-76ef42ea2185" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_23c4def7-3495-4079-912b-fb422828951e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquity" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquity"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_1ebe6d4c-bb28-47e3-bbfd-314b81d33ec0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_abc98f36-4acc-4b8c-aae1-87d73b860f1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_1ebe6d4c-bb28-47e3-bbfd-314b81d33ec0" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_abc98f36-4acc-4b8c-aae1-87d73b860f1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEvent" xlink:type="simple" xlink:href="agnc-20220930.xsd#SubsequentEvent"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SubsequentEvent" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_6a385a92-95c1-4b33-9a8d-5e93114ca2e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_80edbef2-8b9d-4b22-af7a-f47b0cba0e9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_6a385a92-95c1-4b33-9a8d-5e93114ca2e9" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_80edbef2-8b9d-4b22-af7a-f47b0cba0e9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesPolicy" xlink:type="simple" xlink:href="agnc-20220930.xsd#SummaryofSignificantAccountingPoliciesPolicy"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesPolicy" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_c59fd476-a091-45d8-9f1c-64e654fe9732" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_c59fd476-a091-45d8-9f1c-64e654fe9732" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_c69d837e-8093-48ab-af1d-a344b62cf69b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_c59fd476-a091-45d8-9f1c-64e654fe9732" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_c69d837e-8093-48ab-af1d-a344b62cf69b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_ed3b06ed-eec9-440c-84af-980d454c13bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_c69d837e-8093-48ab-af1d-a344b62cf69b" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_ed3b06ed-eec9-440c-84af-980d454c13bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_c59fd476-a091-45d8-9f1c-64e654fe9732" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_6bedebc8-553b-425a-a9b2-cda50b07d386" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_6bedebc8-553b-425a-a9b2-cda50b07d386" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_d2cd15f9-46a0-4a07-8ef0-a425529ba6b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_d2cd15f9-46a0-4a07-8ef0-a425529ba6b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_e0ed67e8-b686-45a9-99f1-679fa010614d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_e0ed67e8-b686-45a9-99f1-679fa010614d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_eb55369b-dc93-4f84-924b-24e4c0718efb" xlink:href="agnc-20220930.xsd#agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_eb55369b-dc93-4f84-924b-24e4c0718efb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_b680ccf0-9638-4221-9b17-ffeb38b81982" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_b680ccf0-9638-4221-9b17-ffeb38b81982" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_de215138-ff8f-4ea1-98c4-52d59ad44c52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableInterestEntityDisclosureTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_de215138-ff8f-4ea1-98c4-52d59ad44c52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_44ce26dc-b99b-4d6f-835d-6a25e8d80c58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_44ce26dc-b99b-4d6f-835d-6a25e8d80c58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_38494c7b-144e-4ae9-87da-88ceac772461" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_UseOfEstimates_38494c7b-144e-4ae9-87da-88ceac772461" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_1fc72a16-3d9b-4ae1-8659-e6bd85a5044b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_1fc72a16-3d9b-4ae1-8659-e6bd85a5044b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_9809dbbb-34c6-4ab7-b810-cba18aad6587" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_9809dbbb-34c6-4ab7-b810-cba18aad6587" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_59ac328c-0aeb-4c28-9d6a-cd21debeff2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_59ac328c-0aeb-4c28-9d6a-cd21debeff2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillDisclosureTextBlock_1c078368-c413-4964-9cf3-7b47679b8348" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillDisclosureTextBlock"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_659c0fb4-ea4a-4e99-b837-78c0d01cad49" xlink:to="loc_us-gaap_GoodwillDisclosureTextBlock_1c078368-c413-4964-9cf3-7b47679b8348" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_f308a2f2-7483-4820-98c7-8dd7f87a1605" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_f308a2f2-7483-4820-98c7-8dd7f87a1605" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_5417549a-7d76-40e1-b759-02d72907b113" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentPolicyTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_5417549a-7d76-40e1-b759-02d72907b113" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_70de8ac9-2bd4-4bca-9746-0bc1d52fb529" xlink:href="agnc-20220930.xsd#agnc_InterestIncomePolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_agnc_InterestIncomePolicyTextBlock_70de8ac9-2bd4-4bca-9746-0bc1d52fb529" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_56195abd-e924-458b-91ba-cd95097e85c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAndResaleAgreementsPolicy"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_56195abd-e924-458b-91ba-cd95097e85c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_35cdc436-eb0b-471f-8e8a-dae9ceae21fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativesPolicyTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_35cdc436-eb0b-471f-8e8a-dae9ceae21fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDisclosures_b3b37b4d-11cb-4a69-88f7-5bb2265b9512" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyDisclosures"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_LossContingencyDisclosures_b3b37b4d-11cb-4a69-88f7-5bb2265b9512" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_16609261-87ce-4146-a13b-958f8a95531b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_16609261-87ce-4146-a13b-958f8a95531b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_b7cb1299-6184-4ddd-8964-a0cc08082423" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_b7cb1299-6184-4ddd-8964-a0cc08082423" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_c972b520-a2f1-4e77-8331-2a5987115dc4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementPolicyPolicyTextBlock"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_c972b520-a2f1-4e77-8331-2a5987115dc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_c1985b5d-a812-43f2-a8f1-ff9a98c2947d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsolidationVariableInterestEntityPolicy"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a2b26397-4792-4bf8-9c48-3c0ebb8e3269" xlink:to="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_c1985b5d-a812-43f2-a8f1-ff9a98c2947d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="simple" xlink:href="agnc-20220930.xsd#SummaryofSignificantAccountingPoliciesAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_b695dbcf-ffd0-47d7-b7f9-25a02b639f61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_8e12fc38-c202-492b-8947-b45fb258cd38" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b695dbcf-ffd0-47d7-b7f9-25a02b639f61" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_8e12fc38-c202-492b-8947-b45fb258cd38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_844afcf6-5eb4-4394-99e7-a5121fbe8eda" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_8e12fc38-c202-492b-8947-b45fb258cd38" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_844afcf6-5eb4-4394-99e7-a5121fbe8eda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_0c6015a5-8be3-4cbc-86d1-4ff2876ff0ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_844afcf6-5eb4-4394-99e7-a5121fbe8eda" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_0c6015a5-8be3-4cbc-86d1-4ff2876ff0ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_c208b664-187c-48ff-8acd-af15251e9f1d" xlink:href="agnc-20220930.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_0c6015a5-8be3-4cbc-86d1-4ff2876ff0ef" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_c208b664-187c-48ff-8acd-af15251e9f1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_4f656127-c7ed-46e6-a9f0-22af50b26177" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_8e12fc38-c202-492b-8947-b45fb258cd38" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_4f656127-c7ed-46e6-a9f0-22af50b26177" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_4c106797-0e6b-42c6-9a3b-75d551056816" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_4f656127-c7ed-46e6-a9f0-22af50b26177" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_4c106797-0e6b-42c6-9a3b-75d551056816" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_8c98b8f1-2a7b-4871-8d85-1107d3ad3315" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativesPolicyTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_4f656127-c7ed-46e6-a9f0-22af50b26177" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_8c98b8f1-2a7b-4871-8d85-1107d3ad3315" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_baa7e6ca-60b8-46b5-90e3-651d08948cdd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentPolicyTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_4f656127-c7ed-46e6-a9f0-22af50b26177" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_baa7e6ca-60b8-46b5-90e3-651d08948cdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_9c409af6-908e-4304-a0f7-421db03165ed" xlink:href="agnc-20220930.xsd#agnc_InterestIncomePolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_4f656127-c7ed-46e6-a9f0-22af50b26177" xlink:to="loc_agnc_InterestIncomePolicyTextBlock_9c409af6-908e-4304-a0f7-421db03165ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ManagementAgreementTextBlock_4b68058c-2838-4c92-b278-3a13f6bb6f99" xlink:href="agnc-20220930.xsd#agnc_ManagementAgreementTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_4f656127-c7ed-46e6-a9f0-22af50b26177" xlink:to="loc_agnc_ManagementAgreementTextBlock_4b68058c-2838-4c92-b278-3a13f6bb6f99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_88bcc77d-b7c5-40f9-aed5-e2920827ccf1" xlink:href="agnc-20220930.xsd#agnc_SecuritiesbyCreditRatingTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_88bcc77d-b7c5-40f9-aed5-e2920827ccf1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_726770b3-7588-4489-9e15-5c7209da2f11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_726770b3-7588-4489-9e15-5c7209da2f11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_f492290e-1b25-464c-9f42-eb1fe451e960" xlink:href="agnc-20220930.xsd#agnc_ComponentsOfInvestmentSecuritiesTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_f492290e-1b25-464c-9f42-eb1fe451e960" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_805ff52a-a1e4-4f0b-b950-d4a97190ca36" xlink:href="agnc-20220930.xsd#agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_805ff52a-a1e4-4f0b-b950-d4a97190ca36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8c027785-6725-4758-81f6-c13c2ad6b723" xlink:href="agnc-20220930.xsd#agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_8c027785-6725-4758-81f6-c13c2ad6b723" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_b2ac4f8c-2b5f-4bd9-93c2-14bd35b8bf2e" xlink:href="agnc-20220930.xsd#agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_b2ac4f8c-2b5f-4bd9-93c2-14bd35b8bf2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_ccacc37a-303a-4430-a9b6-f54b8f3eb352" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_ccacc37a-303a-4430-a9b6-f54b8f3eb352" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock_7aef257f-6dac-4def-a740-de4bb07a7971" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d8b6ff33-7491-4bb7-8d2a-9cd539f7e3df" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock_7aef257f-6dac-4def-a740-de4bb07a7971" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsandReverseRepurchaseAgreementsTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#RepurchaseAgreementsandReverseRepurchaseAgreementsTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsandReverseRepurchaseAgreementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_c7af0592-b359-4964-b8d3-0b0658dd22ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_bb55902a-d6d7-46e3-8eb8-63762dffe48e" xlink:href="agnc-20220930.xsd#agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_c7af0592-b359-4964-b8d3-0b0658dd22ad" xlink:to="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_bb55902a-d6d7-46e3-8eb8-63762dffe48e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_0dcd2f60-658a-4769-a52c-0614349b7b92" xlink:href="agnc-20220930.xsd#agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_c7af0592-b359-4964-b8d3-0b0658dd22ad" xlink:to="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_0dcd2f60-658a-4769-a52c-0614349b7b92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_56df9115-5f15-4515-b018-36fd502eda51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_5f8f025f-ef1e-439b-9e38-ac66a76ed773" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_56df9115-5f15-4515-b018-36fd502eda51" xlink:to="loc_us-gaap_DerivativeTable_5f8f025f-ef1e-439b-9e38-ac66a76ed773" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_1a111a39-5ae8-4d7c-aa20-f3a2c8c9d976" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_5f8f025f-ef1e-439b-9e38-ac66a76ed773" xlink:to="loc_us-gaap_HedgingDesignationAxis_1a111a39-5ae8-4d7c-aa20-f3a2c8c9d976" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_82c9e3ad-b436-469c-93b4-8a9e2d17f598" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_1a111a39-5ae8-4d7c-aa20-f3a2c8c9d976" xlink:to="loc_us-gaap_HedgingDesignationDomain_82c9e3ad-b436-469c-93b4-8a9e2d17f598" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_a4a76bed-979f-4ee2-8f1a-3c7cf8505237" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_82c9e3ad-b436-469c-93b4-8a9e2d17f598" xlink:to="loc_us-gaap_NondesignatedMember_a4a76bed-979f-4ee2-8f1a-3c7cf8505237" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_5f8f025f-ef1e-439b-9e38-ac66a76ed773" xlink:to="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock_f7792eb1-dffa-452b-8399-28f5fab486f7" xlink:href="agnc-20220930.xsd#agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock_f7792eb1-dffa-452b-8399-28f5fab486f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_d8f6ace7-176a-489f-9908-3860f34429ef" xlink:href="agnc-20220930.xsd#agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_d8f6ace7-176a-489f-9908-3860f34429ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_4625819a-9530-4dc5-845f-8c42c43e0911" xlink:href="agnc-20220930.xsd#agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_4625819a-9530-4dc5-845f-8c42c43e0911" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_89099908-576e-46aa-a2b0-40423dba5bd6" xlink:href="agnc-20220930.xsd#agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_89099908-576e-46aa-a2b0-40423dba5bd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_USgovernmentsecuritiesTableTextBlock_d2c26ba1-5eea-479d-9ea0-2c09961b6560" xlink:href="agnc-20220930.xsd#agnc_USgovernmentsecuritiesTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_USgovernmentsecuritiesTableTextBlock_d2c26ba1-5eea-479d-9ea0-2c09961b6560" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_a1677a98-42b2-4565-820e-277092baf0b5" xlink:href="agnc-20220930.xsd#agnc_USGovernmentFuturesSecuritiesTableTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_a1677a98-42b2-4565-820e-277092baf0b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_ea873af0-f7be-4d90-9331-3f4b90c2bd6f" xlink:href="agnc-20220930.xsd#agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_ea873af0-f7be-4d90-9331-3f4b90c2bd6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_cb0320e2-2373-4677-b869-908bdf07e6bb" xlink:href="agnc-20220930.xsd#agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_802c0061-297b-42e0-8f9d-fcd31632b145" xlink:to="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_cb0320e2-2373-4677-b869-908bdf07e6bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/BalanceSheetOffsettingTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#BalanceSheetOffsettingTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/BalanceSheetOffsettingTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_61b6e1da-084e-4394-9eda-9ab5261b9bc7" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsAndOtherLiabilitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOtherAssetsTableTextBlock_966c1122-b226-42b8-a2d7-b545700af6bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfOtherAssetsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_61b6e1da-084e-4394-9eda-9ab5261b9bc7" xlink:to="loc_us-gaap_ScheduleOfOtherAssetsTableTextBlock_966c1122-b226-42b8-a2d7-b545700af6bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesTableTextBlock_49948e8b-a95b-4ede-bcb3-3eca6a9093a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_61b6e1da-084e-4394-9eda-9ab5261b9bc7" xlink:to="loc_us-gaap_OtherLiabilitiesTableTextBlock_49948e8b-a95b-4ede-bcb3-3eca6a9093a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsTableTextBlock_791af06b-7cf2-4ff2-afdc-6f9547444cd6" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_61b6e1da-084e-4394-9eda-9ab5261b9bc7" xlink:to="loc_agnc_OtherAssetsTableTextBlock_791af06b-7cf2-4ff2-afdc-6f9547444cd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssetsTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_018c05e7-1f59-4b02-81a5-50c26524733f" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_52e4c4b4-0d2e-4173-8d1e-df229a0b8146" xlink:href="agnc-20220930.xsd#agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_018c05e7-1f59-4b02-81a5-50c26524733f" xlink:to="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_52e4c4b4-0d2e-4173-8d1e-df229a0b8146" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_b0ef9697-7cc9-4d4e-8e8c-335bacc6b99c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_018c05e7-1f59-4b02-81a5-50c26524733f" xlink:to="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_b0ef9697-7cc9-4d4e-8e8c-335bacc6b99c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsTableTextBlock_71dd0d96-e76b-4668-9326-334dd848a220" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OffsettingAssetsTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_018c05e7-1f59-4b02-81a5-50c26524733f" xlink:to="loc_us-gaap_OffsettingAssetsTableTextBlock_71dd0d96-e76b-4668-9326-334dd848a220" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_abc445d5-4993-478b-b17c-8eda375baafc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OffsettingLiabilitiesTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_018c05e7-1f59-4b02-81a5-50c26524733f" xlink:to="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_abc445d5-4993-478b-b17c-8eda375baafc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_1a4d31ee-8ac9-473b-b9f5-2b47de5c27f7" xlink:href="agnc-20220930.xsd#agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_018c05e7-1f59-4b02-81a5-50c26524733f" xlink:to="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_1a4d31ee-8ac9-473b-b9f5-2b47de5c27f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#FairValueMeasurementsTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_40aa2659-d79c-4c2f-a392-c323ab8bdb8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_2ccda332-5718-4d84-a1c3-da9f9ef3fd3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_40aa2659-d79c-4c2f-a392-c323ab8bdb8e" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_2ccda332-5718-4d84-a1c3-da9f9ef3fd3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#NetIncomeLossPerCommonShareTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityTables"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_0706ef61-a41d-4b12-934b-b0ceca1aa565" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockTableTextBlock_9e2fe404-be01-4f24-8f91-41593a424ccf" xlink:href="agnc-20220930.xsd#agnc_PreferredStockTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_0706ef61-a41d-4b12-934b-b0ceca1aa565" xlink:to="loc_agnc_PreferredStockTableTextBlock_9e2fe404-be01-4f24-8f91-41593a424ccf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTextBlock_d0d8815d-2c3f-4174-80ad-299738b71c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfStockByClassTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_0706ef61-a41d-4b12-934b-b0ceca1aa565" xlink:to="loc_us-gaap_ScheduleOfStockByClassTextBlock_d0d8815d-2c3f-4174-80ad-299738b71c0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsDeclaredTableTextBlock_02507b92-d96d-4385-b5b5-0a35b04ccb3d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsDeclaredTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_0706ef61-a41d-4b12-934b-b0ceca1aa565" xlink:to="loc_us-gaap_DividendsDeclaredTableTextBlock_02507b92-d96d-4385-b5b5-0a35b04ccb3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_ca3b7465-af08-4693-99fb-71d448760f6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_0706ef61-a41d-4b12-934b-b0ceca1aa565" xlink:to="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_ca3b7465-af08-4693-99fb-71d448760f6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock_3207639a-b57f-46d9-851e-1f2ac00d5875" xlink:href="agnc-20220930.xsd#agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_0706ef61-a41d-4b12-934b-b0ceca1aa565" xlink:to="loc_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock_3207639a-b57f-46d9-851e-1f2ac00d5875" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/OrganizationDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#OrganizationDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_a5e384ce-73ef-471f-bf67-53d7c191b3e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_41d8825a-921d-4d34-b2ab-078d9a103a5a" xlink:href="agnc-20220930.xsd#agnc_RequiredAnnualDistributionOfTaxableNetIncome"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_a5e384ce-73ef-471f-bf67-53d7c191b3e7" xlink:to="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_41d8825a-921d-4d34-b2ab-078d9a103a5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_6e1f6fb7-b134-4b7f-a195-bc661273ebab" xlink:href="agnc-20220930.xsd#agnc_IntendedAnnualDistributionofTaxableNetIncome"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_a5e384ce-73ef-471f-bf67-53d7c191b3e7" xlink:to="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_6e1f6fb7-b134-4b7f-a195-bc661273ebab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#SummaryofSignificantAccountingPoliciesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_60575ae2-3eb1-463e-82fd-b219219290c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_374f6270-7ba8-49ae-a67a-eb0f355b24e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_60575ae2-3eb1-463e-82fd-b219219290c8" xlink:to="loc_us-gaap_DerivativeTable_374f6270-7ba8-49ae-a67a-eb0f355b24e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_18715e19-7fe9-41cf-8058-a9872dfb7940" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_374f6270-7ba8-49ae-a67a-eb0f355b24e3" xlink:to="loc_srt_RangeAxis_18715e19-7fe9-41cf-8058-a9872dfb7940" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_03f95428-2065-49f0-931b-d099ec097c10" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_18715e19-7fe9-41cf-8058-a9872dfb7940" xlink:to="loc_srt_RangeMember_03f95428-2065-49f0-931b-d099ec097c10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_5201d40b-c86b-4d8e-9e92-314eefa3a05e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_374f6270-7ba8-49ae-a67a-eb0f355b24e3" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_5201d40b-c86b-4d8e-9e92-314eefa3a05e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_925d191d-acce-49fc-8365-b3194338c226" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_5201d40b-c86b-4d8e-9e92-314eefa3a05e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_925d191d-acce-49fc-8365-b3194338c226" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_bf90972b-4d50-4fca-91f9-56648c9032e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_925d191d-acce-49fc-8365-b3194338c226" xlink:to="loc_us-gaap_InterestRateSwapMember_bf90972b-4d50-4fca-91f9-56648c9032e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_c215f947-2582-469c-9735-7e2ea5b209ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_374f6270-7ba8-49ae-a67a-eb0f355b24e3" xlink:to="loc_us-gaap_DerivativeLineItems_c215f947-2582-469c-9735-7e2ea5b209ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnContractTermination_282f94f1-d9dc-47fc-8532-fc9994e24165" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnContractTermination"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_c215f947-2582-469c-9735-7e2ea5b209ee" xlink:to="loc_us-gaap_GainLossOnContractTermination_282f94f1-d9dc-47fc-8532-fc9994e24165" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_778cd690-bfa1-44de-9a4f-4690dbdb2a66" xlink:href="agnc-20220930.xsd#agnc_RequiredAnnualDistributionOfTaxableNetIncome"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_c215f947-2582-469c-9735-7e2ea5b209ee" xlink:to="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_778cd690-bfa1-44de-9a4f-4690dbdb2a66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_eee2290a-5309-4245-ba16-aca539c0a538" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_c215f947-2582-469c-9735-7e2ea5b209ee" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_eee2290a-5309-4245-ba16-aca539c0a538" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesGoodwillandIntangibleAssetsDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#SummaryofSignificantAccountingPoliciesGoodwillandIntangibleAssetsDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesGoodwillandIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_1f842664-660f-4177-a572-e61a284e7e72" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59d8f05c-debd-4d7f-badb-6f8bd716b14e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_1f842664-660f-4177-a572-e61a284e7e72" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59d8f05c-debd-4d7f-badb-6f8bd716b14e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ac031dc2-5424-4407-9fb5-d197d276fa22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59d8f05c-debd-4d7f-badb-6f8bd716b14e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ac031dc2-5424-4407-9fb5-d197d276fa22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_44a348c2-5ab1-46d4-9a47-ad3e73796c7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ac031dc2-5424-4407-9fb5-d197d276fa22" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_44a348c2-5ab1-46d4-9a47-ad3e73796c7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_07a9d8f8-81d8-4ec2-983d-b617730e50fb" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59d8f05c-debd-4d7f-badb-6f8bd716b14e" xlink:to="loc_srt_ConsolidationItemsAxis_07a9d8f8-81d8-4ec2-983d-b617730e50fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_e9dc2d46-36fc-45eb-a645-fa28e6487da8" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsAxis_07a9d8f8-81d8-4ec2-983d-b617730e50fb" xlink:to="loc_srt_ConsolidationItemsDomain_e9dc2d46-36fc-45eb-a645-fa28e6487da8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_d2182f20-62e4-40e9-9afc-631f33f8dda7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59d8f05c-debd-4d7f-badb-6f8bd716b14e" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_d2182f20-62e4-40e9-9afc-631f33f8dda7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_bfe89a8a-a5d9-461e-899e-d0dfee177630" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_d2182f20-62e4-40e9-9afc-631f33f8dda7" xlink:to="loc_us-gaap_SegmentDomain_bfe89a8a-a5d9-461e-899e-d0dfee177630" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b4e35d00-3351-426f-a800-c28faca9f3c9" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59d8f05c-debd-4d7f-badb-6f8bd716b14e" xlink:to="loc_srt_RangeAxis_b4e35d00-3351-426f-a800-c28faca9f3c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_1aa5764e-b722-45ed-b6c7-5367244036a3" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_b4e35d00-3351-426f-a800-c28faca9f3c9" xlink:to="loc_srt_RangeMember_1aa5764e-b722-45ed-b6c7-5367244036a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_9f907d95-1a76-43eb-bbea-579240148dde" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59d8f05c-debd-4d7f-badb-6f8bd716b14e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_9f907d95-1a76-43eb-bbea-579240148dde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_e2c8e00b-fdb2-42d0-be60-1f1e04020ed0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_9f907d95-1a76-43eb-bbea-579240148dde" xlink:to="loc_us-gaap_Goodwill_e2c8e00b-fdb2-42d0-be60-1f1e04020ed0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_6aa928dd-a158-4d58-898b-7942d721fd7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_9f907d95-1a76-43eb-bbea-579240148dde" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_6aa928dd-a158-4d58-898b-7942d721fd7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#SummaryofSignificantAccountingPoliciesVariableInterestEntitiesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryofSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_VariableInterestEntitiesAbstract_2d180327-10a4-4427-a1d0-8013e3a5ecea" xlink:href="agnc-20220930.xsd#agnc_VariableInterestEntitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_d0bf5d86-e0a8-4383-8ae6-4238afb43b76" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_VariableInterestEntitiesAbstract_2d180327-10a4-4427-a1d0-8013e3a5ecea" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_d0bf5d86-e0a8-4383-8ae6-4238afb43b76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_ab51ae91-633f-4d5a-978d-abab2b6c73c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_d0bf5d86-e0a8-4383-8ae6-4238afb43b76" xlink:to="loc_us-gaap_DebtInstrumentAxis_ab51ae91-633f-4d5a-978d-abab2b6c73c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_c9b261a1-b07d-4cd3-aeef-a3916fcf18da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_ab51ae91-633f-4d5a-978d-abab2b6c73c3" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_c9b261a1-b07d-4cd3-aeef-a3916fcf18da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_89e617d1-298d-4bc2-ab0b-cecfb8510d8c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableInterestEntityLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_d0bf5d86-e0a8-4383-8ae6-4238afb43b76" xlink:to="loc_us-gaap_VariableInterestEntityLineItems_89e617d1-298d-4bc2-ab0b-cecfb8510d8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_ec22b375-8777-48ec-82ed-0f95d43a4655" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLongTermDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_89e617d1-298d-4bc2-ab0b-cecfb8510d8c" xlink:to="loc_us-gaap_OtherLongTermDebt_ec22b375-8777-48ec-82ed-0f95d43a4655" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_1ba80819-a3bf-4848-bccd-40c029101dc0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_89e617d1-298d-4bc2-ab0b-cecfb8510d8c" xlink:to="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_1ba80819-a3bf-4848-bccd-40c029101dc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SpreadOverLibor_b661b099-677e-4940-b497-04abd0065fd0" xlink:href="agnc-20220930.xsd#agnc_SpreadOverLibor"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_89e617d1-298d-4bc2-ab0b-cecfb8510d8c" xlink:to="loc_agnc_SpreadOverLibor_b661b099-677e-4940-b497-04abd0065fd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_9441164e-e918-4e0c-abfa-259b28262fdd" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageLifeOtherDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_89e617d1-298d-4bc2-ab0b-cecfb8510d8c" xlink:to="loc_agnc_WeightedAverageLifeOtherDebt_9441164e-e918-4e0c-abfa-259b28262fdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_a4d1f53d-87c9-4192-b65b-59f46a9e666d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_a4d1f53d-87c9-4192-b65b-59f46a9e666d" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_13f11ab4-7a18-4665-81e2-83e262dfd487" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:to="loc_us-gaap_FinancialInstrumentAxis_13f11ab4-7a18-4665-81e2-83e262dfd487" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c4b8b31d-b162-4365-822a-e17e04ae0861" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_13f11ab4-7a18-4665-81e2-83e262dfd487" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c4b8b31d-b162-4365-822a-e17e04ae0861" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_4a24bc36-9d13-4eb4-a86b-f7b4febbdf13" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c4b8b31d-b162-4365-822a-e17e04ae0861" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_4a24bc36-9d13-4eb4-a86b-f7b4febbdf13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b339e503-40f6-4233-a9ce-bdfe09b5ef81" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:to="loc_srt_RangeAxis_b339e503-40f6-4233-a9ce-bdfe09b5ef81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_8b04d81b-89cd-4d16-b63a-c6e69dbc16ab" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_b339e503-40f6-4233-a9ce-bdfe09b5ef81" xlink:to="loc_srt_RangeMember_8b04d81b-89cd-4d16-b63a-c6e69dbc16ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_edc4a2fb-bfbb-4b73-8329-9c08a631c43e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_8b04d81b-89cd-4d16-b63a-c6e69dbc16ab" xlink:to="loc_srt_MinimumMember_edc4a2fb-bfbb-4b73-8329-9c08a631c43e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_2efba84d-baf9-4189-a374-dc19fb640f37" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_8b04d81b-89cd-4d16-b63a-c6e69dbc16ab" xlink:to="loc_srt_MaximumMember_2efba84d-baf9-4189-a374-dc19fb640f37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_b96ab43d-884d-4afd-8617-3d24932c56a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_b96ab43d-884d-4afd-8617-3d24932c56a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_c6915d38-b0d7-40b8-b151-8ac31e4bfafb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b96ab43d-884d-4afd-8617-3d24932c56a4" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_c6915d38-b0d7-40b8-b151-8ac31e4bfafb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_0fb72a10-e3a0-4cdb-a0cc-21cb413e6af9" xlink:href="agnc-20220930.xsd#agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_c6915d38-b0d7-40b8-b151-8ac31e4bfafb" xlink:to="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_0fb72a10-e3a0-4cdb-a0cc-21cb413e6af9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ForwardSettlingNonAgencySecuritiesMember_bb396edd-11e5-4b5a-a3fb-ffa85ad213ea" xlink:href="agnc-20220930.xsd#agnc_ForwardSettlingNonAgencySecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_c6915d38-b0d7-40b8-b151-8ac31e4bfafb" xlink:to="loc_agnc_ForwardSettlingNonAgencySecuritiesMember_bb396edd-11e5-4b5a-a3fb-ffa85ad213ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_a13ce256-a538-4bcd-8f95-73da0bae9085" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_a13ce256-a538-4bcd-8f95-73da0bae9085" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_3abbcb0d-0791-4165-b7ee-4b041a9701a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_a13ce256-a538-4bcd-8f95-73da0bae9085" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_3abbcb0d-0791-4165-b7ee-4b041a9701a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_0f184b56-7b95-4ee2-a8be-19afb9eecac0" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_3abbcb0d-0791-4165-b7ee-4b041a9701a0" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_0f184b56-7b95-4ee2-a8be-19afb9eecac0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_91717215-0e06-4ec7-a5c7-15b7bcad73dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:to="loc_us-gaap_InvestmentTypeAxis_91717215-0e06-4ec7-a5c7-15b7bcad73dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_f89a1931-e601-41cb-913d-8bdef271dae3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_91717215-0e06-4ec7-a5c7-15b7bcad73dd" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_f89a1931-e601-41cb-913d-8bdef271dae3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AgencySecuritiesMember_979b4fe3-f6e0-4a20-a773-08b183a66af5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AgencySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_f89a1931-e601-41cb-913d-8bdef271dae3" xlink:to="loc_us-gaap_AgencySecuritiesMember_979b4fe3-f6e0-4a20-a773-08b183a66af5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_67ec2391-344a-42f6-9c36-b93f3a6224a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_f89a1931-e601-41cb-913d-8bdef271dae3" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_67ec2391-344a-42f6-9c36-b93f3a6224a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_9c0f8c2a-2569-45af-82de-a3977f4893f9" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_f89a1931-e601-41cb-913d-8bdef271dae3" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_9c0f8c2a-2569-45af-82de-a3977f4893f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_6b17f4ca-b33e-4529-9c56-cddb70e33b61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_f89a1931-e601-41cb-913d-8bdef271dae3" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_6b17f4ca-b33e-4529-9c56-cddb70e33b61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_6703e408-ce82-4054-a252-4e4c885a77a7" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_f7d26bbd-4d47-407c-926e-23c3e08d8004" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_f7d26bbd-4d47-407c-926e-23c3e08d8004" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_d4a74a40-6c97-459c-a0ca-aabeb5a5a18e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_d4a74a40-6c97-459c-a0ca-aabeb5a5a18e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_cae6684f-6ec6-4e0f-b2ab-0f013fbf3cf3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_cae6684f-6ec6-4e0f-b2ab-0f013fbf3cf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_85a322df-6457-4d2c-848f-a155d19c303b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_85a322df-6457-4d2c-848f-a155d19c303b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_564eb064-dfe4-4c4b-856a-5208e8e153f8" xlink:href="agnc-20220930.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_564eb064-dfe4-4c4b-856a-5208e8e153f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageCouponRate_70396900-6ca4-4e3f-af91-6e2ce0d70c4c" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageCouponRate"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_WeightedAverageCouponRate_70396900-6ca4-4e3f-af91-6e2ce0d70c4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_UnderlyingCollateralCoupon_f175be66-6872-4f5e-8398-ad9c9609e275" xlink:href="agnc-20220930.xsd#agnc_UnderlyingCollateralCoupon"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_UnderlyingCollateralCoupon_f175be66-6872-4f5e-8398-ad9c9609e275" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_a4ed6ebf-784f-4ad0-ba77-570105b8459a" xlink:href="agnc-20220930.xsd#agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_a4ed6ebf-784f-4ad0-ba77-570105b8459a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_0fcbc1f1-7ffd-450c-8347-63dfa48d91a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesHeldAsCollateralAtFairValue"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_0fcbc1f1-7ffd-450c-8347-63dfa48d91a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_e0150770-18fe-48d8-b94f-dd2ee492b912" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLongTermDebt"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_OtherLongTermDebt_e0150770-18fe-48d8-b94f-dd2ee492b912" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_469cfe2e-8d96-4b0e-8fcf-36e7b801069a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_469cfe2e-8d96-4b0e-8fcf-36e7b801069a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_1713e934-6a1f-4bb2-a0e7-0fab5364fdd8" xlink:href="agnc-20220930.xsd#agnc_FairValueOfCmoSecuritiesDirectlyHeld"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_1713e934-6a1f-4bb2-a0e7-0fab5364fdd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritizedCmoSecurities_e67552e7-5765-4bca-9b1f-b0293add219c" xlink:href="agnc-20220930.xsd#agnc_SecuritizedCmoSecurities"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_SecuritizedCmoSecurities_e67552e7-5765-4bca-9b1f-b0293add219c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_32fce403-b5c0-4f89-9e59-9d1f3d607b6a" xlink:href="agnc-20220930.xsd#agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_32fce403-b5c0-4f89-9e59-9d1f3d607b6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_af9a8367-174f-4727-95f8-7a85f9c31a48" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_af9a8367-174f-4727-95f8-7a85f9c31a48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_MortgageCreditInvestmentFundLimitedPartnership_0aa304ad-ad62-402b-8a1a-930cb9d67c25" xlink:href="agnc-20220930.xsd#agnc_MortgageCreditInvestmentFundLimitedPartnership"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5e3f073b-03db-4d18-951f-58d69447981b" xlink:to="loc_agnc_MortgageCreditInvestmentFundLimitedPartnership_0aa304ad-ad62-402b-8a1a-930cb9d67c25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryofInvestmentinAgencySecurityDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesInvestmentSecuritiesSummaryofInvestmentinAgencySecurityDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryofInvestmentinAgencySecurityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0e7566c2-4f3c-48c5-bd91-f027baf2c7ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_dd1fad16-4b71-435d-8f84-6bd036310cf3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0e7566c2-4f3c-48c5-bd91-f027baf2c7ef" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_dd1fad16-4b71-435d-8f84-6bd036310cf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_e2ff5f0b-fa6c-4c5a-93a3-2dade8d1c594" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_dd1fad16-4b71-435d-8f84-6bd036310cf3" xlink:to="loc_us-gaap_FinancialInstrumentAxis_e2ff5f0b-fa6c-4c5a-93a3-2dade8d1c594" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_e2ff5f0b-fa6c-4c5a-93a3-2dade8d1c594" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FixedIncomeSecuritiesMember_971c1403-2694-4443-a108-fabc87116829" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FixedIncomeSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:to="loc_us-gaap_FixedIncomeSecuritiesMember_971c1403-2694-4443-a108-fabc87116829" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AdjustableRateMember_2fddec85-f577-47fd-9af0-5e0d8809940c" xlink:href="agnc-20220930.xsd#agnc_AdjustableRateMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:to="loc_agnc_AdjustableRateMember_2fddec85-f577-47fd-9af0-5e0d8809940c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralizedMortgageObligationsMember_73edef1c-99dc-48be-a8e0-1934b7534e85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralizedMortgageObligationsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:to="loc_us-gaap_CollateralizedMortgageObligationsMember_73edef1c-99dc-48be-a8e0-1934b7534e85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MultifamilyMember_8b54fa60-2148-430a-a0ac-9217de2dee42" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MultifamilyMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:to="loc_srt_MultifamilyMember_8b54fa60-2148-430a-a0ac-9217de2dee42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_6d8d2225-ab4f-49b2-a8f6-13869c333b28" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_6d8d2225-ab4f-49b2-a8f6-13869c333b28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AgencySecuritiesMember_3af5e01c-4776-4352-bc19-6bfd4c728cda" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AgencySecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7edda6e8-1fd3-496f-82ba-1de007db7e95" xlink:to="loc_us-gaap_AgencySecuritiesMember_3af5e01c-4776-4352-bc19-6bfd4c728cda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_e793385e-9e56-4850-bd49-4d5844fd3f8c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_dd1fad16-4b71-435d-8f84-6bd036310cf3" xlink:to="loc_us-gaap_InvestmentTypeAxis_e793385e-9e56-4850-bd49-4d5844fd3f8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_1a1a151a-928b-401b-a2fe-e6aa10e8369b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_e793385e-9e56-4850-bd49-4d5844fd3f8c" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_1a1a151a-928b-401b-a2fe-e6aa10e8369b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AgencySecuritiesMember_418b7679-fe49-4fba-aad7-f16cf016553e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AgencySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_1a1a151a-928b-401b-a2fe-e6aa10e8369b" xlink:to="loc_us-gaap_AgencySecuritiesMember_418b7679-fe49-4fba-aad7-f16cf016553e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_afc054df-d13d-4519-ab2f-0da84dec945c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_1a1a151a-928b-401b-a2fe-e6aa10e8369b" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_afc054df-d13d-4519-ab2f-0da84dec945c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_ae6c4ac4-9c78-4081-aa64-e637dd928bcd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_1a1a151a-928b-401b-a2fe-e6aa10e8369b" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_ae6c4ac4-9c78-4081-aa64-e637dd928bcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_ee1fda56-e486-430c-9309-62ebc0f59f5d" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_1a1a151a-928b-401b-a2fe-e6aa10e8369b" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_ee1fda56-e486-430c-9309-62ebc0f59f5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_69271a29-2fc5-44c7-8e67-bd9facd996a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_dd1fad16-4b71-435d-8f84-6bd036310cf3" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_69271a29-2fc5-44c7-8e67-bd9facd996a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_77122286-b26a-4acf-bc32-dd98991f4df7" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_69271a29-2fc5-44c7-8e67-bd9facd996a1" xlink:to="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_77122286-b26a-4acf-bc32-dd98991f4df7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_66970d58-89fe-478e-8c18-a5c5890fe773" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_69271a29-2fc5-44c7-8e67-bd9facd996a1" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_66970d58-89fe-478e-8c18-a5c5890fe773" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TotalAgencySecurities_ebba3e8a-7cd0-4865-9c66-06e0ecf224b8" xlink:href="agnc-20220930.xsd#agnc_TotalAgencySecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_69271a29-2fc5-44c7-8e67-bd9facd996a1" xlink:to="loc_agnc_TotalAgencySecurities_ebba3e8a-7cd0-4865-9c66-06e0ecf224b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_efafb948-6df4-455c-91a3-4a2c4067696b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable_373d2aa0-092d-4a42-82d2-7c643b82d53e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfInvestmentsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_efafb948-6df4-455c-91a3-4a2c4067696b" xlink:to="loc_us-gaap_ScheduleOfInvestmentsTable_373d2aa0-092d-4a42-82d2-7c643b82d53e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_e6c46275-2db3-4230-8121-e16db2c87086" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_373d2aa0-092d-4a42-82d2-7c643b82d53e" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_e6c46275-2db3-4230-8121-e16db2c87086" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_24ea5cb5-f314-4086-b353-a4e06af8832b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_e6c46275-2db3-4230-8121-e16db2c87086" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_24ea5cb5-f314-4086-b353-a4e06af8832b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_dba72155-9565-4bf7-a743-2fd5325f1a5d" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_24ea5cb5-f314-4086-b353-a4e06af8832b" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_dba72155-9565-4bf7-a743-2fd5325f1a5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_d9498a6e-6e20-400d-ab04-9fc54e707ddb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_373d2aa0-092d-4a42-82d2-7c643b82d53e" xlink:to="loc_us-gaap_InvestmentTypeAxis_d9498a6e-6e20-400d-ab04-9fc54e707ddb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_d9498a6e-6e20-400d-ab04-9fc54e707ddb" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_099de97a-3199-4c8a-a607-ddceac9ed84e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_099de97a-3199-4c8a-a607-ddceac9ed84e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_a2281c54-2efa-4b68-81eb-cb4bcea9d026" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_a2281c54-2efa-4b68-81eb-cb4bcea9d026" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_d3cbe126-c0ae-4ef4-ba8a-851e63e2617a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_d3cbe126-c0ae-4ef4-ba8a-851e63e2617a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_859873a9-677d-46ed-83fa-87768553d54e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_859873a9-677d-46ed-83fa-87768553d54e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_73448a8a-7301-4c60-a8ee-0243738f0276" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_73448a8a-7301-4c60-a8ee-0243738f0276" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_2a2197b4-1ba6-4ab0-8865-618d25e58bc9" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_6b4235fc-5ee4-4c7e-9d2b-4a0d2fc45e6c" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_2a2197b4-1ba6-4ab0-8865-618d25e58bc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_7d4008f0-659f-40d5-a112-49a31750b622" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_373d2aa0-092d-4a42-82d2-7c643b82d53e" xlink:to="loc_us-gaap_FinancialInstrumentAxis_7d4008f0-659f-40d5-a112-49a31750b622" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6ec6627c-5a3c-4c27-8ba8-e0d69268e08d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_7d4008f0-659f-40d5-a112-49a31750b622" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6ec6627c-5a3c-4c27-8ba8-e0d69268e08d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_86da2afb-3854-4f64-a850-acb7295c0fdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6ec6627c-5a3c-4c27-8ba8-e0d69268e08d" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_86da2afb-3854-4f64-a850-acb7295c0fdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TradingSecuritiesMember_7e623dbf-a4f5-4da0-a9ac-772eb9f22aa2" xlink:href="agnc-20220930.xsd#agnc_TradingSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6ec6627c-5a3c-4c27-8ba8-e0d69268e08d" xlink:to="loc_agnc_TradingSecuritiesMember_7e623dbf-a4f5-4da0-a9ac-772eb9f22aa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_0e4ba256-2185-4dff-94a3-da25c4880b0d" xlink:href="agnc-20220930.xsd#agnc_SecuritiesRemeasuredatFairValueMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6ec6627c-5a3c-4c27-8ba8-e0d69268e08d" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_0e4ba256-2185-4dff-94a3-da25c4880b0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecurityTypeAxis_b04bbd80-4c85-4b82-b18c-8005874e9712" xlink:href="agnc-20220930.xsd#agnc_SecurityTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_373d2aa0-092d-4a42-82d2-7c643b82d53e" xlink:to="loc_agnc_SecurityTypeAxis_b04bbd80-4c85-4b82-b18c-8005874e9712" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GovernmentAgencyDomain_5af48999-2969-4d21-8424-5ea900a837ce" xlink:href="agnc-20220930.xsd#agnc_GovernmentAgencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeAxis_b04bbd80-4c85-4b82-b18c-8005874e9712" xlink:to="loc_agnc_GovernmentAgencyDomain_5af48999-2969-4d21-8424-5ea900a837ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:href="agnc-20220930.xsd#agnc_SecurityTypeDomain"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeAxis_b04bbd80-4c85-4b82-b18c-8005874e9712" xlink:to="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_45bcb1bd-c98f-4277-8663-16820b3e2584" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_45bcb1bd-c98f-4277-8663-16820b3e2584" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_5f3bb284-e8c0-413b-a1f9-d198cf18cf67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_5f3bb284-e8c0-413b-a1f9-d198cf18cf67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_4aa7e453-401a-4e2b-bba0-aa0f07a1b99c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_4aa7e453-401a-4e2b-bba0-aa0f07a1b99c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_0f6d28ad-7b95-41aa-8355-3d7dc04f8e4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_0f6d28ad-7b95-41aa-8355-3d7dc04f8e4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_680290ff-b937-4560-a3f0-97bbe0138c52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_680290ff-b937-4560-a3f0-97bbe0138c52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_9c532a3f-1ff4-4802-af1d-f6b57b8d5c9b" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_SecurityTypeDomain_b447cd75-16cd-4d12-a411-1ed82f806065" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_9c532a3f-1ff4-4802-af1d-f6b57b8d5c9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfInvestmentsLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_373d2aa0-092d-4a42-82d2-7c643b82d53e" xlink:to="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesPar_430afeae-dbf1-459c-8269-2d258c46631e" xlink:href="agnc-20220930.xsd#agnc_AvailableForSaleSecuritiesPar"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_AvailableForSaleSecuritiesPar_430afeae-dbf1-459c-8269-2d258c46631e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount_31f7ec66-f1f3-4f33-bada-386c54c0d17a" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount_31f7ec66-f1f3-4f33-bada-386c54c0d17a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium_c67455c0-7946-42c5-8008-bfc7b6440644" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium_c67455c0-7946-42c5-8008-bfc7b6440644" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_aed7391f-8150-47e1-be33-907a8e5bb17b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_aed7391f-8150-47e1-be33-907a8e5bb17b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_d040f817-151f-440a-89ab-40202ea9a5aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_d040f817-151f-440a-89ab-40202ea9a5aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium_94c4c024-ab47-43ba-a45b-704076dfcad6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedPremium_94c4c024-ab47-43ba-a45b-704076dfcad6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedGain_7596c05b-27bc-4b6a-9230-29a9d37be5f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesTradingUnrealizedGain"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_DebtSecuritiesTradingUnrealizedGain_7596c05b-27bc-4b6a-9230-29a9d37be5f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss_c3e2d9b4-ed18-4390-88b1-bc1e1b3c1b96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesTradingUnrealizedLoss"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss_c3e2d9b4-ed18-4390-88b1-bc1e1b3c1b96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecuritiesDebt_660da6f4-e952-47d6-b0c7-cbc16595219e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecuritiesDebt"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_TradingSecuritiesDebt_660da6f4-e952-47d6-b0c7-cbc16595219e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_cc919110-d6f9-4ec4-b3c2-33ae83d354ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_cc919110-d6f9-4ec4-b3c2-33ae83d354ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_042693f3-a12a-4d9a-a3c3-436f77a3839d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_042693f3-a12a-4d9a-a3c3-436f77a3839d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses_3341381f-3989-474c-9be0-6145d2fc902c" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses_3341381f-3989-474c-9be0-6145d2fc902c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecuritiesCost_ed9bfe2c-3cef-4e8a-9d57-19bd618ebf19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecuritiesCost"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_TradingSecuritiesCost_ed9bfe2c-3cef-4e8a-9d57-19bd618ebf19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedGains_f6b9efd7-feb1-4491-be81-696971e8dcc5" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedGains"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedGains_f6b9efd7-feb1-4491-be81-696971e8dcc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedLosses_953b30fe-6c0a-4e70-8687-fec7cb5e06fa" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedLosses"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedLosses_953b30fe-6c0a-4e70-8687-fec7cb5e06fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_7528e7aa-df6d-4fd9-b0bb-f9930df166cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_7528e7aa-df6d-4fd9-b0bb-f9930df166cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_c15754cc-90f3-4de4-a32d-d90db4d9c0f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_c15754cc-90f3-4de4-a32d-d90db4d9c0f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f285b0cd-a8f6-4773-9c07-067546b4e8f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f285b0cd-a8f6-4773-9c07-067546b4e8f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TradingSecuritiesPar_cd8547c8-92c3-41c3-a586-f1a7654268f5" xlink:href="agnc-20220930.xsd#agnc_TradingSecuritiesPar"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_TradingSecuritiesPar_cd8547c8-92c3-41c3-a586-f1a7654268f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount_f7ad4baf-4e65-41b1-91e7-721c9ac348ea" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount_f7ad4baf-4e65-41b1-91e7-721c9ac348ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium_b53d2253-0e95-47a2-8e9b-344ff357d0b9" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium_b53d2253-0e95-47a2-8e9b-344ff357d0b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecuritiesDebtAmortizedCost_8df89f9e-5f3f-4e7e-817a-6b0352602e0f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecuritiesDebtAmortizedCost"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_TradingSecuritiesDebtAmortizedCost_8df89f9e-5f3f-4e7e-817a-6b0352602e0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_72fd3382-52c5-4eae-bb8b-5d17189fbf51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_72fd3382-52c5-4eae-bb8b-5d17189fbf51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageYieldPercentage_7ff7dd79-ccf7-49eb-83fe-32ec68db8ee4" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageYieldPercentage"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_WeightedAverageYieldPercentage_7ff7dd79-ccf7-49eb-83fe-32ec68db8ee4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_865d0134-a15f-4cb9-86f0-35c1f390ff15" xlink:href="agnc-20220930.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_865d0134-a15f-4cb9-86f0-35c1f390ff15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_MortgageBackedSecuritiesAmortizedCost_4d6f9049-8f81-48de-a73a-75e5329b673f" xlink:href="agnc-20220930.xsd#agnc_MortgageBackedSecuritiesAmortizedCost"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_MortgageBackedSecuritiesAmortizedCost_4d6f9049-8f81-48de-a73a-75e5329b673f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains_1e43aae5-71f0-4e52-a140-5fa81742cdfa" xlink:href="agnc-20220930.xsd#agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_7bb676b3-1aa5-4039-8190-b2c67fd81b39" xlink:to="loc_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains_1e43aae5-71f0-4e52-a140-5fa81742cdfa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_a0f7adc5-a3f2-4c9d-9f1a-7d4ebeb823d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_8dbbefb8-2e8b-45ab-a99a-8f0a74694553" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_a0f7adc5-a3f2-4c9d-9f1a-7d4ebeb823d9" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_8dbbefb8-2e8b-45ab-a99a-8f0a74694553" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_ae48b32f-0ffd-4ad4-89e5-fd9b0a56997e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_8dbbefb8-2e8b-45ab-a99a-8f0a74694553" xlink:to="loc_us-gaap_FinancialInstrumentAxis_ae48b32f-0ffd-4ad4-89e5-fd9b0a56997e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_45f1b267-766c-4e3c-8cde-2b7a9f307f88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_ae48b32f-0ffd-4ad4-89e5-fd9b0a56997e" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_45f1b267-766c-4e3c-8cde-2b7a9f307f88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LessThanorEqualtoThreeYearsMember_11541889-db66-455b-994c-fb144b1cc5ba" xlink:href="agnc-20220930.xsd#agnc_LessThanorEqualtoThreeYearsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_45f1b267-766c-4e3c-8cde-2b7a9f307f88" xlink:to="loc_agnc_LessThanorEqualtoThreeYearsMember_11541889-db66-455b-994c-fb144b1cc5ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_f6937521-0053-4988-b94b-a4b98ed3ba7b" xlink:href="agnc-20220930.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_45f1b267-766c-4e3c-8cde-2b7a9f307f88" xlink:to="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_f6937521-0053-4988-b94b-a4b98ed3ba7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanFiveYearsMember_a8726d29-38bd-4175-98e5-bb5e2a1a07da" xlink:href="agnc-20220930.xsd#agnc_GreaterThanFiveYearsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_45f1b267-766c-4e3c-8cde-2b7a9f307f88" xlink:to="loc_agnc_GreaterThanFiveYearsMember_a8726d29-38bd-4175-98e5-bb5e2a1a07da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanTenYearsMember_b2bb0daf-71a2-4af6-ae61-56836acac595" xlink:href="agnc-20220930.xsd#agnc_GreaterThanTenYearsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_45f1b267-766c-4e3c-8cde-2b7a9f307f88" xlink:to="loc_agnc_GreaterThanTenYearsMember_b2bb0daf-71a2-4af6-ae61-56836acac595" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_7e07ab11-6f2c-467d-abeb-b42bf5750c3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_8dbbefb8-2e8b-45ab-a99a-8f0a74694553" xlink:to="loc_us-gaap_StatementLineItems_7e07ab11-6f2c-467d-abeb-b42bf5750c3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_6b8468e6-a716-4b39-a820-e1d85d2c911c" xlink:href="agnc-20220930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_7e07ab11-6f2c-467d-abeb-b42bf5750c3a" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_6b8468e6-a716-4b39-a820-e1d85d2c911c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_122fa07b-a2e4-44bf-86d5-87eae2417dc8" xlink:href="agnc-20220930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_7e07ab11-6f2c-467d-abeb-b42bf5750c3a" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_122fa07b-a2e4-44bf-86d5-87eae2417dc8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_ebbda173-a8a3-437b-8d63-101d4e0573bb" xlink:href="agnc-20220930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_7e07ab11-6f2c-467d-abeb-b42bf5750c3a" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_ebbda173-a8a3-437b-8d63-101d4e0573bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_a271533c-c777-4fbe-b4db-90b52965064e" xlink:href="agnc-20220930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_7e07ab11-6f2c-467d-abeb-b42bf5750c3a" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_a271533c-c777-4fbe-b4db-90b52965064e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOCIForAvailableForSaleSecurityDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesSummaryOfChangesInAccumulatedOCIForAvailableForSaleSecurityDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOCIForAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_1c0920b3-b4f5-46dd-bfe6-f20f33d7ccdc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_2b82e3ba-15a6-4d3d-b2c6-6de1e467317d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_1c0920b3-b4f5-46dd-bfe6-f20f33d7ccdc" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_2b82e3ba-15a6-4d3d-b2c6-6de1e467317d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0bfdcab3-0d86-4bf9-add5-9bbf9ec790dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_2b82e3ba-15a6-4d3d-b2c6-6de1e467317d" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0bfdcab3-0d86-4bf9-add5-9bbf9ec790dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_20fa5e49-44de-4779-9591-b715379acb3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0bfdcab3-0d86-4bf9-add5-9bbf9ec790dd" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_20fa5e49-44de-4779-9591-b715379acb3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AgencySecuritiesMember_d72c964c-e3b5-4e66-83d4-5e5a74d92a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AgencySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_20fa5e49-44de-4779-9591-b715379acb3e" xlink:to="loc_us-gaap_AgencySecuritiesMember_d72c964c-e3b5-4e66-83d4-5e5a74d92a0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_1c388a17-83ad-436e-9818-04158f779610" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_2b82e3ba-15a6-4d3d-b2c6-6de1e467317d" xlink:to="loc_us-gaap_StatementLineItems_1c388a17-83ad-436e-9818-04158f779610" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_c220fe1b-fb48-4fd7-9ca0-32d74a0f3fb4" xlink:href="agnc-20220930.xsd#agnc_AccumulatedOtherComprehensiveIncomeLossRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1c388a17-83ad-436e-9818-04158f779610" xlink:to="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_c220fe1b-fb48-4fd7-9ca0-32d74a0f3fb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_5d5835a1-615b-4334-97c8-c2e1e2f3a519" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_c220fe1b-fb48-4fd7-9ca0-32d74a0f3fb4" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_5d5835a1-615b-4334-97c8-c2e1e2f3a519" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9a161b9e-e82b-484b-978c-b960136ac8b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_c220fe1b-fb48-4fd7-9ca0-32d74a0f3fb4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9a161b9e-e82b-484b-978c-b960136ac8b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_0acf58b2-fc58-4f7c-a85a-c8923f4bb414" xlink:href="agnc-20220930.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_c220fe1b-fb48-4fd7-9ca0-32d74a0f3fb4" xlink:to="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_0acf58b2-fc58-4f7c-a85a-c8923f4bb414" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_9eab3da5-00f5-4814-a713-d228f2c0d4a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_c220fe1b-fb48-4fd7-9ca0-32d74a0f3fb4" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_9eab3da5-00f5-4814-a713-d228f2c0d4a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_db0aea39-a9c4-4074-b258-f8e4bb538f5e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_3c864432-dc34-4a84-8777-8f8fdfb93c29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_db0aea39-a9c4-4074-b258-f8e4bb538f5e" xlink:to="loc_us-gaap_StatementTable_3c864432-dc34-4a84-8777-8f8fdfb93c29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_bce94e25-6ece-44ff-a73b-b24660ca12f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_3c864432-dc34-4a84-8777-8f8fdfb93c29" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_bce94e25-6ece-44ff-a73b-b24660ca12f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_fd9a050a-a885-402c-96e9-f58bd71e50a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_bce94e25-6ece-44ff-a73b-b24660ca12f9" xlink:to="loc_us-gaap_EquityComponentDomain_fd9a050a-a885-402c-96e9-f58bd71e50a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_7eb5c13a-5638-4a4a-b26a-31029162dd2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_fd9a050a-a885-402c-96e9-f58bd71e50a6" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_7eb5c13a-5638-4a4a-b26a-31029162dd2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_7f8acc42-7417-4d2c-9790-aad1bed46f4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_3c864432-dc34-4a84-8777-8f8fdfb93c29" xlink:to="loc_us-gaap_FinancialInstrumentAxis_7f8acc42-7417-4d2c-9790-aad1bed46f4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9f75acce-3702-4a5f-9279-39a819a721d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_7f8acc42-7417-4d2c-9790-aad1bed46f4e" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9f75acce-3702-4a5f-9279-39a819a721d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_721d43b7-c8da-4bf5-a4d9-af8b7c566771" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9f75acce-3702-4a5f-9279-39a819a721d1" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_721d43b7-c8da-4bf5-a4d9-af8b7c566771" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_3c864432-dc34-4a84-8777-8f8fdfb93c29" xlink:to="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_07602119-87f5-452d-8794-27819dd17bf9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_07602119-87f5-452d-8794-27819dd17bf9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_49f0f155-dd6f-4cf1-93e9-0f3136d7beba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_49f0f155-dd6f-4cf1-93e9-0f3136d7beba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_c4802e39-018a-453b-8119-81ad33cbf7d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_c4802e39-018a-453b-8119-81ad33cbf7d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_3944b8fb-4057-4f69-8903-f352d5773657" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_3944b8fb-4057-4f69-8903-f352d5773657" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_5f3dcd52-ad63-4478-8aec-24feb40bbabf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_5f3dcd52-ad63-4478-8aec-24feb40bbabf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2468f21d-5c76-4767-90cf-7663155dd044" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2468f21d-5c76-4767-90cf-7663155dd044" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_c8fea1c1-742b-4f44-878a-ed5b46a2f224" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_c8fea1c1-742b-4f44-878a-ed5b46a2f224" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_affabd82-a923-4e12-aad2-1e5c71cb4a52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_affabd82-a923-4e12-aad2-1e5c71cb4a52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_ba67a4d2-8af3-4c40-a470-17166c1bc124" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_86a34ec4-8bc2-406d-a01e-ac1a979f71cb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_ba67a4d2-8af3-4c40-a470-17166c1bc124" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_bddbe182-0b81-4528-8670-ece6a812b79a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_edfe3fc4-6d90-4242-9213-00c991681250" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_bddbe182-0b81-4528-8670-ece6a812b79a" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_edfe3fc4-6d90-4242-9213-00c991681250" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_78d41907-be6e-43c2-98e9-dd222de4bed4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_edfe3fc4-6d90-4242-9213-00c991681250" xlink:to="loc_us-gaap_InvestmentTypeAxis_78d41907-be6e-43c2-98e9-dd222de4bed4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_bc4c7217-4eac-4d61-88c9-e392ef67b142" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_78d41907-be6e-43c2-98e9-dd222de4bed4" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_bc4c7217-4eac-4d61-88c9-e392ef67b142" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_164665a9-b7a8-4456-a400-926f63ca1701" xlink:href="agnc-20220930.xsd#agnc_CostandProceedsofInvestmentSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_bc4c7217-4eac-4d61-88c9-e392ef67b142" xlink:to="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_164665a9-b7a8-4456-a400-926f63ca1701" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_060e43cf-3e2b-4fc4-863e-4f21b5d6e6ea" xlink:href="agnc-20220930.xsd#agnc_GrossGainLossofInvestmentSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_bc4c7217-4eac-4d61-88c9-e392ef67b142" xlink:to="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_060e43cf-3e2b-4fc4-863e-4f21b5d6e6ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_8d55e4ec-973c-4972-b024-f051414a46e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_edfe3fc4-6d90-4242-9213-00c991681250" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_8d55e4ec-973c-4972-b024-f051414a46e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_e4e2022f-c2d3-47e0-8edd-e1d33f27b7e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_8d55e4ec-973c-4972-b024-f051414a46e4" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_e4e2022f-c2d3-47e0-8edd-e1d33f27b7e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_1973911f-2c38-44cf-8f3e-9206eee8e199" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_e4e2022f-c2d3-47e0-8edd-e1d33f27b7e2" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_1973911f-2c38-44cf-8f3e-9206eee8e199" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_5d23ce18-2b9d-46c2-8149-e63114c993ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_edfe3fc4-6d90-4242-9213-00c991681250" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_5d23ce18-2b9d-46c2-8149-e63114c993ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_259babc5-d724-4782-b59a-e1e824eeac50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_5d23ce18-2b9d-46c2-8149-e63114c993ff" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_259babc5-d724-4782-b59a-e1e824eeac50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_3c291935-da4d-4a4c-bac8-e4708213e5d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_259babc5-d724-4782-b59a-e1e824eeac50" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_3c291935-da4d-4a4c-bac8-e4708213e5d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_e27708b7-664e-420d-94b0-93cb348eadfd" xlink:href="agnc-20220930.xsd#agnc_SecuritiesRemeasuredatFairValueMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_259babc5-d724-4782-b59a-e1e824eeac50" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_e27708b7-664e-420d-94b0-93cb348eadfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesAssetsMember_9f3ae1a7-699e-4ffb-9272-b2801cfb6a04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesAssetsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_259babc5-d724-4782-b59a-e1e824eeac50" xlink:to="loc_us-gaap_SecuritiesAssetsMember_9f3ae1a7-699e-4ffb-9272-b2801cfb6a04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_edfe3fc4-6d90-4242-9213-00c991681250" xlink:to="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GainLossOnOtherDebt_319c0fff-f0ed-43f8-9fde-e092d47874ad" xlink:href="agnc-20220930.xsd#agnc_GainLossOnOtherDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_agnc_GainLossOnOtherDebt_319c0fff-f0ed-43f8-9fde-e092d47874ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_8c300254-3c0d-4b05-a5a6-4c915112a090" xlink:href="agnc-20220930.xsd#agnc_CostOfSaleOfAvailableForSaleSecuities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_8c300254-3c0d-4b05-a5a6-4c915112a090" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CostofSaleofFairValueOptionSecurities_7f148197-af2f-43d4-a15e-9d15f355b56c" xlink:href="agnc-20220930.xsd#agnc_CostofSaleofFairValueOptionSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_agnc_CostofSaleofFairValueOptionSecurities_7f148197-af2f-43d4-a15e-9d15f355b56c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CostofSaleofInvestmentSecurities_7cc8312e-3622-4543-8f09-40bc063ebef9" xlink:href="agnc-20220930.xsd#agnc_CostofSaleofInvestmentSecurities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_agnc_CostofSaleofInvestmentSecurities_7cc8312e-3622-4543-8f09-40bc063ebef9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsFromSaleOfDebtSecurities_a2e975be-3f74-4923-b964-f53d340cf2d6" xlink:href="agnc-20220930.xsd#agnc_ProceedsFromSaleOfDebtSecurities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_agnc_ProceedsFromSaleOfDebtSecurities_a2e975be-3f74-4923-b964-f53d340cf2d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsFromSaleOfDebtSecuritiesTrading_4dd9c095-be3e-4e1c-9602-39969ed48190" xlink:href="agnc-20220930.xsd#agnc_ProceedsFromSaleOfDebtSecuritiesTrading"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_agnc_ProceedsFromSaleOfDebtSecuritiesTrading_4dd9c095-be3e-4e1c-9602-39969ed48190" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_f1e0a8a2-b2ca-4bc4-bf4a-2af43ea2c92a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_f1e0a8a2-b2ca-4bc4-bf4a-2af43ea2c92a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_773beccf-9540-43be-b8f4-b3e1b04e8eca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_773beccf-9540-43be-b8f4-b3e1b04e8eca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_d0addc80-4f1f-4c2f-88e9-b1e99d097590" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_d0addc80-4f1f-4c2f-88e9-b1e99d097590" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_f2b92bb1-51a3-4070-adfb-937a02366435" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGain"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_f2b92bb1-51a3-4070-adfb-937a02366435" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_3009342b-c699-4ec3-b6f2-3b6df5ccbd73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_3009342b-c699-4ec3-b6f2-3b6df5ccbd73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_3b3cc777-afce-402a-8279-9a4eb0f08ff4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5c145793-8987-4afe-a942-0e2fa7105577" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_3b3cc777-afce-402a-8279-9a4eb0f08ff4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesbyCreditRatingDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#InvestmentSecuritiesSecuritiesbyCreditRatingDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesbyCreditRatingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d739a693-e910-40d5-8328-942454d03fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_cb285bcd-a535-4d95-997d-8dc54821d0f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d739a693-e910-40d5-8328-942454d03fb9" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_cb285bcd-a535-4d95-997d-8dc54821d0f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRatingAxis_970e0096-d466-4793-8f60-40a1ffac405f" xlink:href="agnc-20220930.xsd#agnc_CreditRatingAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_cb285bcd-a535-4d95-997d-8dc54821d0f1" xlink:to="loc_agnc_CreditRatingAxis_970e0096-d466-4793-8f60-40a1ffac405f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:href="agnc-20220930.xsd#agnc_CreditRatingDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingAxis_970e0096-d466-4793-8f60-40a1ffac405f" xlink:to="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BBBRatingMember_90c2361f-5a63-408a-9cae-d84b6c16540e" xlink:href="agnc-20220930.xsd#agnc_BBBRatingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:to="loc_agnc_BBBRatingMember_90c2361f-5a63-408a-9cae-d84b6c16540e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BBRatingMember_8d9a5d6a-1616-47a4-99b0-211cde2780a1" xlink:href="agnc-20220930.xsd#agnc_BBRatingMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:to="loc_agnc_BBRatingMember_8d9a5d6a-1616-47a4-99b0-211cde2780a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AAARatingMember_0ca05b3e-aa05-4662-b89a-ac8e854789d1" xlink:href="agnc-20220930.xsd#agnc_AAARatingMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:to="loc_agnc_AAARatingMember_0ca05b3e-aa05-4662-b89a-ac8e854789d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AARatingMember_1225286a-3d27-4457-b4d1-8e6abc755582" xlink:href="agnc-20220930.xsd#agnc_AARatingMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:to="loc_agnc_AARatingMember_1225286a-3d27-4457-b4d1-8e6abc755582" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ARatingMember_61b27b02-d696-4b7a-85fa-2544399c7ef8" xlink:href="agnc-20220930.xsd#agnc_ARatingMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:to="loc_agnc_ARatingMember_61b27b02-d696-4b7a-85fa-2544399c7ef8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BRatingMember_9b188468-9c94-41b2-89d0-62c1cf272f2e" xlink:href="agnc-20220930.xsd#agnc_BRatingMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:to="loc_agnc_BRatingMember_9b188468-9c94-41b2-89d0-62c1cf272f2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotRatedMember_efddaf60-16e6-48bd-9839-04216f07c827" xlink:href="agnc-20220930.xsd#agnc_NotRatedMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_c0bcfd20-a3d6-4315-8250-f387245e6976" xlink:to="loc_agnc_NotRatedMember_efddaf60-16e6-48bd-9839-04216f07c827" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_04e9c79d-63aa-4b27-abe8-5f4874973d0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_cb285bcd-a535-4d95-997d-8dc54821d0f1" xlink:to="loc_us-gaap_FinancialInstrumentAxis_04e9c79d-63aa-4b27-abe8-5f4874973d0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_527671a6-47a4-4832-9d4c-fb1378a48daa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_04e9c79d-63aa-4b27-abe8-5f4874973d0e" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_527671a6-47a4-4832-9d4c-fb1378a48daa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_95b806f3-5f2b-4863-a16a-134a94edd547" xlink:href="agnc-20220930.xsd#agnc_SecuritiesRemeasuredatFairValueMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_527671a6-47a4-4832-9d4c-fb1378a48daa" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_95b806f3-5f2b-4863-a16a-134a94edd547" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_9b728f60-d8e6-4317-8696-2955d279195a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_527671a6-47a4-4832-9d4c-fb1378a48daa" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_9b728f60-d8e6-4317-8696-2955d279195a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_4cfdcec0-943a-420c-aa9c-9fd8b2b47580" xlink:href="agnc-20220930.xsd#agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_527671a6-47a4-4832-9d4c-fb1378a48daa" xlink:to="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_4cfdcec0-943a-420c-aa9c-9fd8b2b47580" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_015baa4c-e3cc-4589-ad03-0f5d6085b33b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_cb285bcd-a535-4d95-997d-8dc54821d0f1" xlink:to="loc_us-gaap_InvestmentTypeAxis_015baa4c-e3cc-4589-ad03-0f5d6085b33b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_d83557f5-ecf4-411d-aaf3-03cbaa41bef0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_015baa4c-e3cc-4589-ad03-0f5d6085b33b" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_d83557f5-ecf4-411d-aaf3-03cbaa41bef0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_db64100c-c233-48bd-9a56-71421e7b11ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_d83557f5-ecf4-411d-aaf3-03cbaa41bef0" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_db64100c-c233-48bd-9a56-71421e7b11ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_61ae44f1-12a6-404e-b65a-8b668990259c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_d83557f5-ecf4-411d-aaf3-03cbaa41bef0" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_61ae44f1-12a6-404e-b65a-8b668990259c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_863d7809-9e1a-4dcb-aedb-ede78b73ede0" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_d83557f5-ecf4-411d-aaf3-03cbaa41bef0" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_863d7809-9e1a-4dcb-aedb-ede78b73ede0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_60da0eb1-bfa8-490b-8b76-f8e40c4bc42f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_cb285bcd-a535-4d95-997d-8dc54821d0f1" xlink:to="loc_srt_RangeAxis_60da0eb1-bfa8-490b-8b76-f8e40c4bc42f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_3460b6f2-f315-443d-9852-4ba77fab1156" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_60da0eb1-bfa8-490b-8b76-f8e40c4bc42f" xlink:to="loc_srt_RangeMember_3460b6f2-f315-443d-9852-4ba77fab1156" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_04f54605-ae48-4cd4-a859-92672335ea2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_cb285bcd-a535-4d95-997d-8dc54821d0f1" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_04f54605-ae48-4cd4-a859-92672335ea2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecuritiesDebt_d8914ebf-4b35-4d6b-ac9f-ff9facbb82a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecuritiesDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_04f54605-ae48-4cd4-a859-92672335ea2f" xlink:to="loc_us-gaap_TradingSecuritiesDebt_d8914ebf-4b35-4d6b-ac9f-ff9facbb82a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_bea6388b-4209-4639-92c9-c49cf833f6fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_04f54605-ae48-4cd4-a859-92672335ea2f" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_bea6388b-4209-4639-92c9-c49cf833f6fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_737aaf74-574a-4f9f-add1-02241c8318b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_6894d951-c442-40ad-8ff9-757fd129cb1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_737aaf74-574a-4f9f-add1-02241c8318b3" xlink:to="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_6894d951-c442-40ad-8ff9-757fd129cb1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_6ee8276f-2295-4cac-abdd-865233a73374" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_6894d951-c442-40ad-8ff9-757fd129cb1d" xlink:to="loc_srt_CounterpartyNameAxis_6ee8276f-2295-4cac-abdd-865233a73374" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d3cde56b-6042-43cf-9e47-9af72502b44e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_6ee8276f-2295-4cac-abdd-865233a73374" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d3cde56b-6042-43cf-9e47-9af72502b44e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BethesdaSecuritiesMember_a19659d8-8d3f-4193-8bed-9731c699b1d3" xlink:href="agnc-20220930.xsd#agnc_BethesdaSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d3cde56b-6042-43cf-9e47-9af72502b44e" xlink:to="loc_agnc_BethesdaSecuritiesMember_a19659d8-8d3f-4193-8bed-9731c699b1d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FICCMember_95296d52-f6f8-4524-b941-132ec96b29b6" xlink:href="agnc-20220930.xsd#agnc_FICCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d3cde56b-6042-43cf-9e47-9af72502b44e" xlink:to="loc_agnc_FICCMember_95296d52-f6f8-4524-b941-132ec96b29b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_3cdd1688-9437-4e0b-83e8-eafe923c41df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_6894d951-c442-40ad-8ff9-757fd129cb1d" xlink:to="loc_us-gaap_FinancialInstrumentAxis_3cdd1688-9437-4e0b-83e8-eafe923c41df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d3a9b4e6-5753-4d2d-9249-78e01c213243" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_3cdd1688-9437-4e0b-83e8-eafe923c41df" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d3a9b4e6-5753-4d2d-9249-78e01c213243" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_0be6e640-9ed6-4b29-b96d-6fd718450a6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d3a9b4e6-5753-4d2d-9249-78e01c213243" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_0be6e640-9ed6-4b29-b96d-6fd718450a6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_02e46635-dc95-4b4f-95bd-b11ea0d1cf71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_6894d951-c442-40ad-8ff9-757fd129cb1d" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_02e46635-dc95-4b4f-95bd-b11ea0d1cf71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_8f73ff36-ba20-4e64-a30e-47c6e59e1a11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_02e46635-dc95-4b4f-95bd-b11ea0d1cf71" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_8f73ff36-ba20-4e64-a30e-47c6e59e1a11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityOvernightMember_73d03e5f-4961-4c84-a3de-b535544e787d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityOvernightMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_8f73ff36-ba20-4e64-a30e-47c6e59e1a11" xlink:to="loc_us-gaap_MaturityOvernightMember_73d03e5f-4961-4c84-a3de-b535544e787d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForwardContractsMember_10607c29-061a-4679-bfe1-c817ea1c158f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForwardContractsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_8f73ff36-ba20-4e64-a30e-47c6e59e1a11" xlink:to="loc_us-gaap_ForwardContractsMember_10607c29-061a-4679-bfe1-c817ea1c158f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_a1a5c54a-d169-4bfa-aa3f-8e9d9eb7be4a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_6894d951-c442-40ad-8ff9-757fd129cb1d" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_a1a5c54a-d169-4bfa-aa3f-8e9d9eb7be4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_f125fc66-a7a4-4112-90a7-d52d463582fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_a1a5c54a-d169-4bfa-aa3f-8e9d9eb7be4a" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_f125fc66-a7a4-4112-90a7-d52d463582fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_11edc42f-05e9-4694-a72a-03e84ab80234" xlink:href="agnc-20220930.xsd#agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f125fc66-a7a4-4112-90a7-d52d463582fd" xlink:to="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_11edc42f-05e9-4694-a72a-03e84ab80234" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_4d23df4f-bfaf-4765-ae54-0785df4e6dd4" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f125fc66-a7a4-4112-90a7-d52d463582fd" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_4d23df4f-bfaf-4765-ae54-0785df4e6dd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_6894d951-c442-40ad-8ff9-757fd129cb1d" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_17aa43a2-7e3f-4443-9edf-5933721a2981" xlink:href="agnc-20220930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_17aa43a2-7e3f-4443-9edf-5933721a2981" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_75e67435-af1b-4010-8c0b-d071eddad35e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_75e67435-af1b-4010-8c0b-d071eddad35e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeForwardSettlementValue_aca81d7d-160e-4189-8846-b8404e27f375" xlink:href="agnc-20220930.xsd#agnc_DerivativeForwardSettlementValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_DerivativeForwardSettlementValue_aca81d7d-160e-4189-8846-b8404e27f375" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_a2f1a822-3768-4d41-8edc-19fd8682fc31" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_a2f1a822-3768-4d41-8edc-19fd8682fc31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PercentageofRepurchaseAgreementFunding_b417664c-08e6-47f2-a107-9ee97b638d2e" xlink:href="agnc-20220930.xsd#agnc_PercentageofRepurchaseAgreementFunding"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_PercentageofRepurchaseAgreementFunding_b417664c-08e6-47f2-a107-9ee97b638d2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_a84e28b7-a220-421b-9eab-049202604687" xlink:href="agnc-20220930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_a84e28b7-a220-421b-9eab-049202604687" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageForwardStartDate_993655bb-f2ee-4dae-88ec-13bfdf89b761" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageForwardStartDate"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_WeightedAverageForwardStartDate_993655bb-f2ee-4dae-88ec-13bfdf89b761" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageForwardStartDays_c49b967d-7ef3-45eb-8626-3acec5bf7107" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageForwardStartDays"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_WeightedAverageForwardStartDays_c49b967d-7ef3-45eb-8626-3acec5bf7107" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_28dcf280-6e6e-4d56-90f6-2bac2d0667be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_28dcf280-6e6e-4d56-90f6-2bac2d0667be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_ea8181ec-548e-49f0-b035-682abad174db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLongTermDebt"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_OtherLongTermDebt_ea8181ec-548e-49f0-b035-682abad174db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_fc69121c-2fc6-4e90-98e0-52c7c5eece04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_fc69121c-2fc6-4e90-98e0-52c7c5eece04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SpreadOverLibor_ec4dfe6a-bf9a-4b64-8c69-eb4b47289fc9" xlink:href="agnc-20220930.xsd#agnc_SpreadOverLibor"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_SpreadOverLibor_ec4dfe6a-bf9a-4b64-8c69-eb4b47289fc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_98439dff-77cd-43b9-9832-93c87f398b0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_98439dff-77cd-43b9-9832-93c87f398b0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_830ca081-e0e8-42db-9f16-31c62dcc14d6" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageLifeOtherDebt"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_WeightedAverageLifeOtherDebt_830ca081-e0e8-42db-9f16-31c62dcc14d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt_4cd80e56-9f16-4a28-91d5-eccb2809adde" xlink:href="agnc-20220930.xsd#agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt_4cd80e56-9f16-4a28-91d5-eccb2809adde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt_82a37dea-a0f9-4238-8457-46de705d066d" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt_82a37dea-a0f9-4238-8457-46de705d066d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3a92ca94-551f-4af9-a5f5-c4b5096fef13" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3a92ca94-551f-4af9-a5f5-c4b5096fef13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageInterestRateOfRepurchaseAgreementsExtinguishedExtinguishedDebt_df9d3b86-d3cc-4023-b4a3-a7f96f825575" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageInterestRateOfRepurchaseAgreementsExtinguishedExtinguishedDebt"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_agnc_WeightedAverageInterestRateOfRepurchaseAgreementsExtinguishedExtinguishedDebt_df9d3b86-d3cc-4023-b4a3-a7f96f825575" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime_4c4532e9-762b-4980-a43e-ad5f3714d146" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_f0e0ca43-d73f-4728-90f9-98d26ea1dc9d" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime_4c4532e9-762b-4980-a43e-ad5f3714d146" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_33a92f6d-894c-4026-b832-915433b8fcca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_33a92f6d-894c-4026-b832-915433b8fcca" xlink:to="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_a8b5d84c-b651-4dd3-9ee9-5efc3dedfde0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_a8b5d84c-b651-4dd3-9ee9-5efc3dedfde0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_07c7e323-8544-4859-bfa6-1628a4332359" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_a8b5d84c-b651-4dd3-9ee9-5efc3dedfde0" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_07c7e323-8544-4859-bfa6-1628a4332359" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_9acf81b5-7f3b-4512-8082-ed418bef5f30" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_07c7e323-8544-4859-bfa6-1628a4332359" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_9acf81b5-7f3b-4512-8082-ed418bef5f30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_c397d777-cb00-4afd-9277-fdbd476f7647" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:to="loc_srt_CounterpartyNameAxis_c397d777-cb00-4afd-9277-fdbd476f7647" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ca6d6a62-14f3-4380-9efc-f974f1c24f35" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_c397d777-cb00-4afd-9277-fdbd476f7647" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ca6d6a62-14f3-4380-9efc-f974f1c24f35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FICCMember_186404c9-5e26-4af9-b253-29e6fcd62bd4" xlink:href="agnc-20220930.xsd#agnc_FICCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ca6d6a62-14f3-4380-9efc-f974f1c24f35" xlink:to="loc_agnc_FICCMember_186404c9-5e26-4af9-b253-29e6fcd62bd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_29b96d53-562c-41c8-905f-8756810ae8bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:to="loc_us-gaap_FinancialInstrumentAxis_29b96d53-562c-41c8-905f-8756810ae8bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d800e47d-191c-447f-a331-ad48e0b35558" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_29b96d53-562c-41c8-905f-8756810ae8bb" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d800e47d-191c-447f-a331-ad48e0b35558" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_00d62130-5608-489b-b482-006dd14af48e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d800e47d-191c-447f-a331-ad48e0b35558" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_00d62130-5608-489b-b482-006dd14af48e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_f8391a8e-3fba-43d5-b431-c85f9fe3810d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:to="loc_us-gaap_DebtInstrumentAxis_f8391a8e-3fba-43d5-b431-c85f9fe3810d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_97faa1ca-77d6-45f1-b22b-88f010db7aad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_f8391a8e-3fba-43d5-b431-c85f9fe3810d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_97faa1ca-77d6-45f1-b22b-88f010db7aad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_f75200c0-a319-42ea-bd50-79cacbf9c847" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_97faa1ca-77d6-45f1-b22b-88f010db7aad" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_f75200c0-a319-42ea-bd50-79cacbf9c847" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_3644c04c-c0c4-4967-b9af-ddd0bd06dbb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_97faa1ca-77d6-45f1-b22b-88f010db7aad" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_3644c04c-c0c4-4967-b9af-ddd0bd06dbb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_4e94c6b5-0f7c-4dc0-9051-dee7d51c93fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_4e94c6b5-0f7c-4dc0-9051-dee7d51c93fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_4e94c6b5-0f7c-4dc0-9051-dee7d51c93fe" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityOvernightMember_b5467454-9694-4fa9-888a-0985361494c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityOvernightMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_us-gaap_MaturityOvernightMember_b5467454-9694-4fa9-888a-0985361494c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_36385900-3a60-4856-b559-13470c9b93db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityUpTo30DaysMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_36385900-3a60-4856-b559-13470c9b93db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ThirtyOneToNinetyMember_bc1b89af-5e80-4f8d-8855-fe2ee01babd5" xlink:href="agnc-20220930.xsd#agnc_ThirtyOneToNinetyMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_ThirtyOneToNinetyMember_bc1b89af-5e80-4f8d-8855-fe2ee01babd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A4to6MonthsMember_8a3d15cd-ef64-4717-8e7f-81114f7d6a26" xlink:href="agnc-20220930.xsd#agnc_A4to6MonthsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A4to6MonthsMember_8a3d15cd-ef64-4717-8e7f-81114f7d6a26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A7to9monthsMember_2e97047e-ba6f-47bb-807f-21692cc76ec9" xlink:href="agnc-20220930.xsd#agnc_A7to9monthsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A7to9monthsMember_2e97047e-ba6f-47bb-807f-21692cc76ec9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A10to12MonthsMember_a0b1b7f2-ffb1-41e9-ab8d-433419f96145" xlink:href="agnc-20220930.xsd#agnc_A10to12MonthsMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A10to12MonthsMember_a0b1b7f2-ffb1-41e9-ab8d-433419f96145" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A13to24MonthsMember_19409e5b-4945-426f-889e-2115eb5c13e6" xlink:href="agnc-20220930.xsd#agnc_A13to24MonthsMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A13to24MonthsMember_19409e5b-4945-426f-889e-2115eb5c13e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A25to36monthsMember_9e408e1c-2e41-47c2-aa70-41b07d7139bd" xlink:href="agnc-20220930.xsd#agnc_A25to36monthsMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A25to36monthsMember_9e408e1c-2e41-47c2-aa70-41b07d7139bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A37to48monthsMember_47882275-d326-43a7-8ec8-4e42d4fc2ac2" xlink:href="agnc-20220930.xsd#agnc_A37to48monthsMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A37to48monthsMember_47882275-d326-43a7-8ec8-4e42d4fc2ac2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A49to60MonthsMember_b7c967c7-423e-4912-a4ec-9b16720861ac" xlink:href="agnc-20220930.xsd#agnc_A49to60MonthsMember"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A49to60MonthsMember_b7c967c7-423e-4912-a4ec-9b16720861ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A2Daysto1MonthMember_d83ebcfe-4dfb-4442-b46c-72f9560b08b4" xlink:href="agnc-20220930.xsd#agnc_A2Daysto1MonthMember"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_ee10cc71-aedb-4b93-b0ee-eb3e1395bc36" xlink:to="loc_agnc_A2Daysto1MonthMember_d83ebcfe-4dfb-4442-b46c-72f9560b08b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_25f6df8d-6914-40ef-94f0-b4353f873998" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_d71f747c-5403-4a18-b350-5563514b8dd3" xlink:to="loc_us-gaap_StatementLineItems_25f6df8d-6914-40ef-94f0-b4353f873998" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_1316e564-2a18-4b80-8122-6bd0d0e21651" xlink:href="agnc-20220930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_25f6df8d-6914-40ef-94f0-b4353f873998" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_1316e564-2a18-4b80-8122-6bd0d0e21651" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_095648bc-3202-46dd-8bd2-9162f29a21c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_25f6df8d-6914-40ef-94f0-b4353f873998" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_095648bc-3202-46dd-8bd2-9162f29a21c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_1a961e94-8c12-4db0-a77a-a57d65c556f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_25f6df8d-6914-40ef-94f0-b4353f873998" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_1a961e94-8c12-4db0-a77a-a57d65c556f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_f97b55b9-70bd-4474-a834-7ebff265345b" xlink:href="agnc-20220930.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_25f6df8d-6914-40ef-94f0-b4353f873998" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_f97b55b9-70bd-4474-a834-7ebff265345b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_622019a4-4dae-473f-ac7a-0c6dc4e13310" xlink:href="agnc-20220930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_25f6df8d-6914-40ef-94f0-b4353f873998" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_622019a4-4dae-473f-ac7a-0c6dc4e13310" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_b48d507e-8488-4c8f-afc4-e870f3403293" xlink:href="agnc-20220930.xsd#agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShortTermDebtTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_b48d507e-8488-4c8f-afc4-e870f3403293" xlink:to="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_3c8aed89-e9a0-4a52-bd76-c334cd0bec14" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:to="loc_srt_RangeAxis_3c8aed89-e9a0-4a52-bd76-c334cd0bec14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7857e287-8dc4-4818-8091-0f367c7e53cd" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_3c8aed89-e9a0-4a52-bd76-c334cd0bec14" xlink:to="loc_srt_RangeMember_7857e287-8dc4-4818-8091-0f367c7e53cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_d72c075e-a081-4271-a675-9f83b036b529" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_d72c075e-a081-4271-a675-9f83b036b529" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_d381c19e-91ae-4417-9eb4-734ca5504406" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_d72c075e-a081-4271-a675-9f83b036b529" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_d381c19e-91ae-4417-9eb4-734ca5504406" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A37to48monthsMember_8def7035-e991-4d33-bab6-6aca6eb4ceda" xlink:href="agnc-20220930.xsd#agnc_A37to48monthsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_d381c19e-91ae-4417-9eb4-734ca5504406" xlink:to="loc_agnc_A37to48monthsMember_8def7035-e991-4d33-bab6-6aca6eb4ceda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_73d16e07-9ade-43b6-8382-3e147f2f46e1" xlink:href="agnc-20220930.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:to="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_73d16e07-9ade-43b6-8382-3e147f2f46e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_77e951d2-1061-4e41-9306-79a7a6760ba5" xlink:href="agnc-20220930.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_73d16e07-9ade-43b6-8382-3e147f2f46e1" xlink:to="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_77e951d2-1061-4e41-9306-79a7a6760ba5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A49to60MonthsMember_94bac6a0-88fb-407d-9a0f-3ee5b734c0c3" xlink:href="agnc-20220930.xsd#agnc_A49to60MonthsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_77e951d2-1061-4e41-9306-79a7a6760ba5" xlink:to="loc_agnc_A49to60MonthsMember_94bac6a0-88fb-407d-9a0f-3ee5b734c0c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A37to48monthsMember_751d9c17-9941-49c9-82ca-9ac40e644453" xlink:href="agnc-20220930.xsd#agnc_A37to48monthsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_77e951d2-1061-4e41-9306-79a7a6760ba5" xlink:to="loc_agnc_A37to48monthsMember_751d9c17-9941-49c9-82ca-9ac40e644453" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_39bc1182-0fdb-44c7-b29a-92a25a2daf04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityUpTo30DaysMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_77e951d2-1061-4e41-9306-79a7a6760ba5" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_39bc1182-0fdb-44c7-b29a-92a25a2daf04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ThirtyOneToNinetyMember_5ee0f70f-0a0c-440b-b54b-6a907abdf11c" xlink:href="agnc-20220930.xsd#agnc_ThirtyOneToNinetyMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_77e951d2-1061-4e41-9306-79a7a6760ba5" xlink:to="loc_agnc_ThirtyOneToNinetyMember_5ee0f70f-0a0c-440b-b54b-6a907abdf11c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A4to6MonthsMember_4a0c80a8-7872-4fca-ba2f-e6a5e504898c" xlink:href="agnc-20220930.xsd#agnc_A4to6MonthsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_77e951d2-1061-4e41-9306-79a7a6760ba5" xlink:to="loc_agnc_A4to6MonthsMember_4a0c80a8-7872-4fca-ba2f-e6a5e504898c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_67aa0195-e651-4c46-8f3c-5fb6f387098f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_67aa0195-e651-4c46-8f3c-5fb6f387098f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_38bbd2ad-6631-48e6-b564-26c934711a78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_67aa0195-e651-4c46-8f3c-5fb6f387098f" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_38bbd2ad-6631-48e6-b564-26c934711a78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_d07cafd5-6e0a-41d6-b92e-b7f0c9d48dae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:to="loc_us-gaap_DebtInstrumentAxis_d07cafd5-6e0a-41d6-b92e-b7f0c9d48dae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_b2dad86e-f88d-4cf4-b1a7-b8f821ac17dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_d07cafd5-6e0a-41d6-b92e-b7f0c9d48dae" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_b2dad86e-f88d-4cf4-b1a7-b8f821ac17dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtLineItems_f8bb0b83-fbb5-4933-8c70-99e1255a3dab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_bf393066-443d-4185-ae64-5691b721d761" xlink:to="loc_us-gaap_ShortTermDebtLineItems_f8bb0b83-fbb5-4933-8c70-99e1255a3dab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_5ae0f210-8a8b-4a0b-a90d-56399981ddb2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtPercentageBearingFixedInterestRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtLineItems_f8bb0b83-fbb5-4933-8c70-99e1255a3dab" xlink:to="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_5ae0f210-8a8b-4a0b-a90d-56399981ddb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_36c4ca58-72f8-4910-93a5-e86a20087d79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtLineItems_f8bb0b83-fbb5-4933-8c70-99e1255a3dab" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_36c4ca58-72f8-4910-93a5-e86a20087d79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_3956f196-9511-435a-a9d8-52590a65063c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_3956f196-9511-435a-a9d8-52590a65063c" xlink:to="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_c58380d2-55d5-4d3d-9025-455ff8c2e980" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_InvestmentTypeAxis_c58380d2-55d5-4d3d-9025-455ff8c2e980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_72fed0c3-d315-4b67-ae04-1c5763ede52e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_c58380d2-55d5-4d3d-9025-455ff8c2e980" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_72fed0c3-d315-4b67-ae04-1c5763ede52e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativesMember_c299e978-dfbe-488f-aae8-2dc904060abd" xlink:href="agnc-20220930.xsd#agnc_OtherDerivativesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_72fed0c3-d315-4b67-ae04-1c5763ede52e" xlink:to="loc_agnc_OtherDerivativesMember_c299e978-dfbe-488f-aae8-2dc904060abd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_0b1ea5b7-33ba-43e9-af50-903f37c5e0d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_PositionAxis_0b1ea5b7-33ba-43e9-af50-903f37c5e0d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_285dd90d-9240-4135-998a-88bb0c9157f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_0b1ea5b7-33ba-43e9-af50-903f37c5e0d1" xlink:to="loc_us-gaap_PositionDomain_285dd90d-9240-4135-998a-88bb0c9157f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_1ed99dc8-3167-4e59-a6dd-19fd5c3a2179" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_285dd90d-9240-4135-998a-88bb0c9157f8" xlink:to="loc_us-gaap_ShortMember_1ed99dc8-3167-4e59-a6dd-19fd5c3a2179" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember_e39834c4-c7c0-494c-a0ae-a3392dcec03e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_285dd90d-9240-4135-998a-88bb0c9157f8" xlink:to="loc_us-gaap_LongMember_e39834c4-c7c0-494c-a0ae-a3392dcec03e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_a8f04dc5-3206-43f2-83cf-5944a7a88ba4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_HedgingDesignationAxis_a8f04dc5-3206-43f2-83cf-5944a7a88ba4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_721fa8d9-fe9e-4051-9c54-69f2b6eb69d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_a8f04dc5-3206-43f2-83cf-5944a7a88ba4" xlink:to="loc_us-gaap_HedgingDesignationDomain_721fa8d9-fe9e-4051-9c54-69f2b6eb69d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_2d01c4fd-a696-4f5a-b65e-2c1bf1941779" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_721fa8d9-fe9e-4051-9c54-69f2b6eb69d4" xlink:to="loc_us-gaap_NondesignatedMember_2d01c4fd-a696-4f5a-b65e-2c1bf1941779" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_30c0eb6b-05e9-4063-931a-325536367a65" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_30c0eb6b-05e9-4063-931a-325536367a65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_30c0eb6b-05e9-4063-931a-325536367a65" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_b99b2ca0-570a-4b05-a3af-da8aad523005" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:to="loc_us-gaap_FutureMember_b99b2ca0-570a-4b05-a3af-da8aad523005" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForwardContractsMember_a613058f-316e-4c53-9082-983c763ae179" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForwardContractsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:to="loc_us-gaap_ForwardContractsMember_a613058f-316e-4c53-9082-983c763ae179" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwaptionMember_3b317ba3-7be6-4f94-bab7-eaf3fefe855c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwaptionMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:to="loc_us-gaap_InterestRateSwaptionMember_3b317ba3-7be6-4f94-bab7-eaf3fefe855c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_64549454-6d6f-4d3d-940e-dd778509b6c7" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_64549454-6d6f-4d3d-940e-dd778509b6c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_27cb7a22-659f-479f-8b19-a2a42f532e68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_27cb7a22-659f-479f-8b19-a2a42f532e68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditDefaultSwapMember_2a4053c5-c90b-4b47-a3a3-e78f961996d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditDefaultSwapMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_a1080b07-7783-4eb8-bc9c-7f2e34bb8a60" xlink:to="loc_us-gaap_CreditDefaultSwapMember_2a4053c5-c90b-4b47-a3a3-e78f961996d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_3e8559c9-218d-457c-bfa3-8e9b3675be9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_30c0eb6b-05e9-4063-931a-325536367a65" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_3e8559c9-218d-457c-bfa3-8e9b3675be9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionAxis_e895288f-a6b1-4c63-8943-d6aff47a973e" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_agnc_DerivativePositionAxis_e895288f-a6b1-4c63-8943-d6aff47a973e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionDomain_feea3ab9-53ae-431b-87cf-752881494fb9" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_e895288f-a6b1-4c63-8943-d6aff47a973e" xlink:to="loc_agnc_DerivativePositionDomain_feea3ab9-53ae-431b-87cf-752881494fb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_0be1c7e0-a44b-492f-8865-f9a784f55b85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_feea3ab9-53ae-431b-87cf-752881494fb9" xlink:to="loc_us-gaap_InterestRateSwapMember_0be1c7e0-a44b-492f-8865-f9a784f55b85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_d4f2a3de-db3f-407b-bbd4-1d42bc88b8f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_d4f2a3de-db3f-407b-bbd4-1d42bc88b8f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_aee2fd7b-adb1-459e-aa46-23bf8d48ea10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_d4f2a3de-db3f-407b-bbd4-1d42bc88b8f2" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_aee2fd7b-adb1-459e-aa46-23bf8d48ea10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_ca206ab7-ce83-4ff0-9975-e5fcdfe8ff74" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_aee2fd7b-adb1-459e-aa46-23bf8d48ea10" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_ca206ab7-ce83-4ff0-9975-e5fcdfe8ff74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_13022949-97ce-407c-a99f-4506bef7c9a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_13022949-97ce-407c-a99f-4506bef7c9a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_56e75c6b-4449-4469-bc5e-0df6624d6edc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_13022949-97ce-407c-a99f-4506bef7c9a0" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_56e75c6b-4449-4469-bc5e-0df6624d6edc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_4912d76b-3d66-4e27-bb21-a05b50ab169b" xlink:href="agnc-20220930.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_56e75c6b-4449-4469-bc5e-0df6624d6edc" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_4912d76b-3d66-4e27-bb21-a05b50ab169b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_81b9d495-cb29-4f65-a5bf-56c61d247128" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_81b9d495-cb29-4f65-a5bf-56c61d247128" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_6337a1bb-b8d9-4aae-b31a-104f8050b06c" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationAxis"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_6337a1bb-b8d9-4aae-b31a-104f8050b06c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_6f0ef24c-8a25-4519-affd-28e5de66f884" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_6337a1bb-b8d9-4aae-b31a-104f8050b06c" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_6f0ef24c-8a25-4519-affd-28e5de66f884" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AtCostBasisMember_c74f7732-21cc-47f8-ac3f-3fdb3fb03f09" xlink:href="agnc-20220930.xsd#agnc_AtCostBasisMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_6f0ef24c-8a25-4519-affd-28e5de66f884" xlink:to="loc_agnc_AtCostBasisMember_c74f7732-21cc-47f8-ac3f-3fdb3fb03f09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AtCarryingValueMember_30790e7e-f4db-44a5-98ed-2b3a5ee1fc84" xlink:href="agnc-20220930.xsd#agnc_AtCarryingValueMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_6f0ef24c-8a25-4519-affd-28e5de66f884" xlink:to="loc_agnc_AtCarryingValueMember_30790e7e-f4db-44a5-98ed-2b3a5ee1fc84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_c807d775-cbce-4fb5-a7c3-76bb7f98fe6b" xlink:to="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GainLossOnOtherDebt_e331cda9-a6be-4ea5-8737-7a9e76a828b0" xlink:href="agnc-20220930.xsd#agnc_GainLossOnOtherDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_GainLossOnOtherDebt_e331cda9-a6be-4ea5-8737-7a9e76a828b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_530dfd40-2100-427c-a683-55213259c297" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_530dfd40-2100-427c-a683-55213259c297" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_19f44e28-63aa-454a-945e-87bf64af37f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_19f44e28-63aa-454a-945e-87bf64af37f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_e498984b-0b6f-4790-b8ac-99e61de0d659" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_e498984b-0b6f-4790-b8ac-99e61de0d659" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_0d6ec2e0-bb66-401a-a556-2cc1d6274f55" xlink:href="agnc-20220930.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_0d6ec2e0-bb66-401a-a556-2cc1d6274f55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_b1d5208d-f2d2-48cc-9eae-841fd14edbdf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_b1d5208d-f2d2-48cc-9eae-841fd14edbdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_dcc7611b-a7a8-4e1f-a448-6e6b9bd96cb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_dcc7611b-a7a8-4e1f-a448-6e6b9bd96cb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_ffa9202d-0a1f-4e69-9990-fa61178f2fd3" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_ffa9202d-0a1f-4e69-9990-fa61178f2fd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_4e225348-38f3-4bd9-8a0a-e13d7cf253b1" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_4e225348-38f3-4bd9-8a0a-e13d7cf253b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_fd42e480-46d0-4641-af3d-f95a01e8313f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_fd42e480-46d0-4641-af3d-f95a01e8313f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_f1501454-b2c2-47a3-99d5-83563452b2bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_f1501454-b2c2-47a3-99d5-83563452b2bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OptionsAtCost_f78ef2b3-0217-4f14-bbec-9d381298b74c" xlink:href="agnc-20220930.xsd#agnc_OptionsAtCost"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_OptionsAtCost_f78ef2b3-0217-4f14-bbec-9d381298b74c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_90f14b4b-cb5a-4ae2-ba58-bb1a1ff091cb" xlink:href="agnc-20220930.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_90f14b4b-cb5a-4ae2-ba58-bb1a1ff091cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_5ba1874a-e6e8-44c5-bd72-559038aadea6" xlink:href="agnc-20220930.xsd#agnc_TradingSecuritiesAddedDuringthePeriod"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_5ba1874a-e6e8-44c5-bd72-559038aadea6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_b3539429-2db1-44bc-8e98-6718677cceea" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_b3539429-2db1-44bc-8e98-6718677cceea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities_593dfe0c-21c9-44da-a236-b71fcde445ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecurities"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_TradingSecurities_593dfe0c-21c9-44da-a236-b71fcde445ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_26ce597d-37f2-452e-8905-af212e3c1249" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DerivativeAssets_26ce597d-37f2-452e-8905-af212e3c1249" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgeLiabilitiesAtFairValue_7be3ba95-3bf7-436c-b705-8d76e5018f82" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueHedgeLiabilitiesAtFairValue"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_FairValueHedgeLiabilitiesAtFairValue_7be3ba95-3bf7-436c-b705-8d76e5018f82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_8b95db7b-cd23-43bf-809a-13f5125d74f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_8b95db7b-cd23-43bf-809a-13f5125d74f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_1c9169e9-ee50-4f50-8f4e-c6d182307598" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_1c9169e9-ee50-4f50-8f4e-c6d182307598" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditDefaultSwaps_b27f3483-974b-42f0-a8db-fe36d949a5dd" xlink:href="agnc-20220930.xsd#agnc_CreditDefaultSwaps"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ae5d0a3c-ea70-4a7b-b8f0-168081b1d434" xlink:to="loc_agnc_CreditDefaultSwaps_b27f3483-974b-42f0-a8db-fe36d949a5dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsFairValueInformationDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_ce6263f5-5244-42d5-bf5f-75e4c69af46c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_ce6263f5-5244-42d5-bf5f-75e4c69af46c" xlink:to="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_8b117c86-b180-4aea-9622-df08c1e25841" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:to="loc_us-gaap_PositionAxis_8b117c86-b180-4aea-9622-df08c1e25841" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_8e159476-1bd8-4dff-b600-a961a42507cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_8b117c86-b180-4aea-9622-df08c1e25841" xlink:to="loc_us-gaap_PositionDomain_8e159476-1bd8-4dff-b600-a961a42507cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_0eac6dec-9356-45b0-9d33-0808acdac588" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_8e159476-1bd8-4dff-b600-a961a42507cb" xlink:to="loc_us-gaap_ShortMember_0eac6dec-9356-45b0-9d33-0808acdac588" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember_926b52b4-dac4-4b59-96d8-3dc0efa56774" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_8e159476-1bd8-4dff-b600-a961a42507cb" xlink:to="loc_us-gaap_LongMember_926b52b4-dac4-4b59-96d8-3dc0efa56774" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_42220722-99b2-4d29-97df-4ad82a053b19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:to="loc_us-gaap_HedgingDesignationAxis_42220722-99b2-4d29-97df-4ad82a053b19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_5e529f1f-c5a5-470a-bbec-59bf5b0c32ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_42220722-99b2-4d29-97df-4ad82a053b19" xlink:to="loc_us-gaap_HedgingDesignationDomain_5e529f1f-c5a5-470a-bbec-59bf5b0c32ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_5e95476d-dad2-42d4-91b3-2fb519e3d4a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_5e529f1f-c5a5-470a-bbec-59bf5b0c32ec" xlink:to="loc_us-gaap_NondesignatedMember_5e95476d-dad2-42d4-91b3-2fb519e3d4a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_7fea4557-ff4f-4ad7-8c1b-db5395ff5b37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_7fea4557-ff4f-4ad7-8c1b-db5395ff5b37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_e57b6bf4-8873-4742-8eab-8fb475622a60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_7fea4557-ff4f-4ad7-8c1b-db5395ff5b37" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_e57b6bf4-8873-4742-8eab-8fb475622a60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_af654d7f-7110-4c64-bfcb-2522b1e0501a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_e57b6bf4-8873-4742-8eab-8fb475622a60" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_af654d7f-7110-4c64-bfcb-2522b1e0501a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_29016155-a497-4756-ac78-0ceae1c51359" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_e57b6bf4-8873-4742-8eab-8fb475622a60" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_29016155-a497-4756-ac78-0ceae1c51359" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember_71bba916-0754-472f-b1c0-d3479680594b" xlink:href="agnc-20220930.xsd#agnc_SaleOfTBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_e57b6bf4-8873-4742-8eab-8fb475622a60" xlink:to="loc_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember_71bba916-0754-472f-b1c0-d3479680594b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_5c8dec2d-6caa-42ca-96db-600edddca914" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_5c8dec2d-6caa-42ca-96db-600edddca914" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_7de440d1-e7bb-497e-b206-3ff563f5e985" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_5c8dec2d-6caa-42ca-96db-600edddca914" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_7de440d1-e7bb-497e-b206-3ff563f5e985" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_356d507e-4617-44cf-85d4-f1c99c5fd5d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_7de440d1-e7bb-497e-b206-3ff563f5e985" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_356d507e-4617-44cf-85d4-f1c99c5fd5d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_b07c4058-32fe-4f8a-adb1-3b4e013cbc73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_b07c4058-32fe-4f8a-adb1-3b4e013cbc73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b07c4058-32fe-4f8a-adb1-3b4e013cbc73" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_da3e22d5-a19f-4ca5-85c7-20d232a87516" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_da3e22d5-a19f-4ca5-85c7-20d232a87516" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_b20cbd9d-1bb3-4533-90ab-7bd3f398b980" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:to="loc_us-gaap_InterestRateSwapMember_b20cbd9d-1bb3-4533-90ab-7bd3f398b980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwaptionMember_b63e5900-f1ab-4b51-8851-bed722074364" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwaptionMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:to="loc_us-gaap_InterestRateSwaptionMember_b63e5900-f1ab-4b51-8851-bed722074364" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_eec3e2c0-b849-4c0b-bd68-0c14b53e3844" xlink:href="agnc-20220930.xsd#agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:to="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_eec3e2c0-b849-4c0b-bd68-0c14b53e3844" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_30a3e97a-60cd-47c1-95ff-da56cac5b673" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:to="loc_us-gaap_FutureMember_30a3e97a-60cd-47c1-95ff-da56cac5b673" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_ea378a4d-55d9-424f-a570-0545b99740a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_ea378a4d-55d9-424f-a570-0545b99740a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditDefaultSwapMember_7e5cab42-2f0d-4c7d-8789-afea02acd831" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditDefaultSwapMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97857d3e-088d-40ff-b501-7a02628bec68" xlink:to="loc_us-gaap_CreditDefaultSwapMember_7e5cab42-2f0d-4c7d-8789-afea02acd831" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_79678149-42dc-4780-8d02-e6ef012d0820" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_79678149-42dc-4780-8d02-e6ef012d0820" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_98e417fb-6641-4ae0-9a21-3f1b469f33fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_79678149-42dc-4780-8d02-e6ef012d0820" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_98e417fb-6641-4ae0-9a21-3f1b469f33fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_d51aab5f-678b-4418-ba72-486593bd72e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_98e417fb-6641-4ae0-9a21-3f1b469f33fc" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_d51aab5f-678b-4418-ba72-486593bd72e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_f585ef35-6a69-4b92-9cc9-ceebd5637ee9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_98e417fb-6641-4ae0-9a21-3f1b469f33fc" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_f585ef35-6a69-4b92-9cc9-ceebd5637ee9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_007f3dc3-948a-4ce4-b7ee-5d90d14575f2" xlink:to="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_c80e6bbe-50fa-449f-8d99-e4dba0ea7f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_c80e6bbe-50fa-449f-8d99-e4dba0ea7f8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_6b5c1265-6c7e-4155-80b4-9f5e18dbf992" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_6b5c1265-6c7e-4155-80b4-9f5e18dbf992" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_5a76f78d-4454-42ed-a7f1-3d5cc0480972" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_5a76f78d-4454-42ed-a7f1-3d5cc0480972" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_93823d27-007b-4243-ba03-dfa884075093" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_DerivativeAssets_93823d27-007b-4243-ba03-dfa884075093" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_1f9f7f6d-0452-4507-b541-e93231537ee0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_DerivativeLiabilities_1f9f7f6d-0452-4507-b541-e93231537ee0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_a321f848-70bd-41e7-99b6-9fbf9a22a41f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_a321f848-70bd-41e7-99b6-9fbf9a22a41f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_5598d053-b6a2-4cd8-9034-964e1f237d4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_5598d053-b6a2-4cd8-9034-964e1f237d4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_eea5c52b-0377-4aa1-b781-9fa6fa059075" xlink:href="agnc-20220930.xsd#agnc_Governmentbondsownedandsoldshortnet"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_agnc_Governmentbondsownedandsoldshortnet_eea5c52b-0377-4aa1-b781-9fa6fa059075" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_49379fb2-76c6-4bc8-9bbd-797d516ca5ed" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_49379fb2-76c6-4bc8-9bbd-797d516ca5ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_69b82696-fc11-491f-85b7-ed61c40598f3" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_69b82696-fc11-491f-85b7-ed61c40598f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_c880fa85-8c5c-454f-909f-68053cd9e2de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_c880fa85-8c5c-454f-909f-68053cd9e2de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities_d86911df-d1f3-47fc-b989-1cfcf6d3695a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecurities"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_us-gaap_TradingSecurities_d86911df-d1f3-47fc-b989-1cfcf6d3695a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_4a3218ae-de2b-4a8a-937c-19376fb23b4d" xlink:href="agnc-20220930.xsd#agnc_TradingSecuritiesAddedDuringthePeriod"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_4a3218ae-de2b-4a8a-937c-19376fb23b4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_764a9187-6818-4908-b18a-17f65f17aa0e" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_764a9187-6818-4908-b18a-17f65f17aa0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativeAsset_1dfef635-f515-44d5-bdf6-15716fdf08bc" xlink:href="agnc-20220930.xsd#agnc_OtherDerivativeAsset"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_agnc_OtherDerivativeAsset_1dfef635-f515-44d5-bdf6-15716fdf08bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NetFairValueOfInterestRateSwapsExcludingTheRecognitionOfVariationMarginSettlementsAsAReductionOfCarryingValue_a3052643-6adc-4c76-a8fb-a322b82e584a" xlink:href="agnc-20220930.xsd#agnc_NetFairValueOfInterestRateSwapsExcludingTheRecognitionOfVariationMarginSettlementsAsAReductionOfCarryingValue"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_dde5eb81-4818-4fc6-9999-222de5fed2d7" xlink:to="loc_agnc_NetFairValueOfInterestRateSwapsExcludingTheRecognitionOfVariationMarginSettlementsAsAReductionOfCarryingValue_a3052643-6adc-4c76-a8fb-a322b82e584a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_aa048f7b-eebd-4275-bde3-68f592ba77fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_aa048f7b-eebd-4275-bde3-68f592ba77fb" xlink:to="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_b3d8f669-1f03-4786-833f-c69fa2136d73" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_b3d8f669-1f03-4786-833f-c69fa2136d73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_dc4674b6-ea74-4b65-8dce-c28663e3bcbf" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_b3d8f669-1f03-4786-833f-c69fa2136d73" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_dc4674b6-ea74-4b65-8dce-c28663e3bcbf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_29df58cb-edb7-4b3c-bc64-3a44148e23f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_29df58cb-edb7-4b3c-bc64-3a44148e23f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_3cd97204-c56f-4801-a79f-e837a392d8b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_29df58cb-edb7-4b3c-bc64-3a44148e23f9" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_3cd97204-c56f-4801-a79f-e837a392d8b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3c21aa1e-8ddf-49fe-a480-6b73b9747fa9" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_3cd97204-c56f-4801-a79f-e837a392d8b5" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3c21aa1e-8ddf-49fe-a480-6b73b9747fa9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_ff0f8922-fc8b-4355-be0d-2e56cd223ba9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_us-gaap_InvestmentTypeAxis_ff0f8922-fc8b-4355-be0d-2e56cd223ba9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_fcabc7a1-d20e-41aa-8130-c069802cf1d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_ff0f8922-fc8b-4355-be0d-2e56cd223ba9" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_fcabc7a1-d20e-41aa-8130-c069802cf1d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativesMember_77b53dda-08ce-42f4-95a1-accd03256065" xlink:href="agnc-20220930.xsd#agnc_OtherDerivativesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_fcabc7a1-d20e-41aa-8130-c069802cf1d3" xlink:to="loc_agnc_OtherDerivativesMember_77b53dda-08ce-42f4-95a1-accd03256065" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BermudanMember_029f89ce-741d-4207-800f-03ffde445a10" xlink:href="agnc-20220930.xsd#agnc_BermudanMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_fcabc7a1-d20e-41aa-8130-c069802cf1d3" xlink:to="loc_agnc_BermudanMember_029f89ce-741d-4207-800f-03ffde445a10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesByMaturityAxis_9b758cf1-4430-4acc-bfab-7b9847a45a1b" xlink:href="agnc-20220930.xsd#agnc_DerivativesByMaturityAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_agnc_DerivativesByMaturityAxis_9b758cf1-4430-4acc-bfab-7b9847a45a1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:href="agnc-20220930.xsd#agnc_DerivativesByMaturityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_9b758cf1-4430-4acc-bfab-7b9847a45a1b" xlink:to="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_e2e32075-be8b-41a6-86a9-3d9a0f9885ba" xlink:href="agnc-20220930.xsd#agnc_LessThanOrEqualToOneYearMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_LessThanOrEqualToOneYearMember_e2e32075-be8b-41a6-86a9-3d9a0f9885ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_b2d2592f-9311-4f17-87ad-3d53dc63098b" xlink:href="agnc-20220930.xsd#agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_b2d2592f-9311-4f17-87ad-3d53dc63098b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_9145dbd2-b4ee-479a-9985-aedb0fe25701" xlink:href="agnc-20220930.xsd#agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_9145dbd2-b4ee-479a-9985-aedb0fe25701" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_ce4d57a7-2b51-43d6-9d7e-923cbe7ae02e" xlink:href="agnc-20220930.xsd#agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_ce4d57a7-2b51-43d6-9d7e-923cbe7ae02e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_5b155340-57b2-4a24-b41c-3119ca8cb84f" xlink:href="agnc-20220930.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_5b155340-57b2-4a24-b41c-3119ca8cb84f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_35aaa124-9fd6-4848-9ba5-3ceb2e37a49a" xlink:href="agnc-20220930.xsd#agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_35aaa124-9fd6-4848-9ba5-3ceb2e37a49a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_02db9bc7-53b4-4ec4-9179-a6dfe3ee436e" xlink:href="agnc-20220930.xsd#agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_02db9bc7-53b4-4ec4-9179-a6dfe3ee436e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanTenYearsMember_680b9591-2af0-4967-93c2-6f1d1b8b9ace" xlink:href="agnc-20220930.xsd#agnc_GreaterThanTenYearsMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanTenYearsMember_680b9591-2af0-4967-93c2-6f1d1b8b9ace" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember_4fe8b314-1433-4351-b093-60091df1ba9d" xlink:href="agnc-20220930.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d940972f-510a-4996-a276-ec4a9f1523ee" xlink:to="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember_4fe8b314-1433-4351-b093-60091df1ba9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_7cf534bf-98cd-47a0-8a4c-3a53a68a2343" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_7cf534bf-98cd-47a0-8a4c-3a53a68a2343" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_7cf534bf-98cd-47a0-8a4c-3a53a68a2343" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PayerSwaptionMember_efb3680b-063b-4876-bf18-bc88edc3a83f" xlink:href="agnc-20220930.xsd#agnc_PayerSwaptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:to="loc_agnc_PayerSwaptionMember_efb3680b-063b-4876-bf18-bc88edc3a83f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwaptionMember_c6c2f836-5db9-4f58-a4d0-936a3780d5b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwaptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:to="loc_us-gaap_InterestRateSwaptionMember_c6c2f836-5db9-4f58-a4d0-936a3780d5b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForwardContractsMember_e888f95c-9782-4b26-939b-20e7560184f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForwardContractsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:to="loc_us-gaap_ForwardContractsMember_e888f95c-9782-4b26-939b-20e7560184f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_66b2f4ad-2205-40fe-837d-2b58761b5fa8" xlink:href="agnc-20220930.xsd#agnc_InterestRateSwapsExcludingForwardStartingMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:to="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_66b2f4ad-2205-40fe-837d-2b58761b5fa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_3ba7d32f-948b-468f-bca6-b90b426cbb47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:to="loc_us-gaap_InterestRateSwapMember_3ba7d32f-948b-468f-bca6-b90b426cbb47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceiverSwaptionMember_65208e51-07e1-41ad-983a-cce726c249c4" xlink:href="agnc-20220930.xsd#agnc_ReceiverSwaptionMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f478cd6d-1fa0-4f67-a283-425040ad0548" xlink:to="loc_agnc_ReceiverSwaptionMember_65208e51-07e1-41ad-983a-cce726c249c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionAxis_2af610f9-afee-4f5d-92a7-a46db3d582ff" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_agnc_DerivativePositionAxis_2af610f9-afee-4f5d-92a7-a46db3d582ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionDomain_1dce58f2-8bbd-4592-ae3e-9234c706a56f" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_2af610f9-afee-4f5d-92a7-a46db3d582ff" xlink:to="loc_agnc_DerivativePositionDomain_1dce58f2-8bbd-4592-ae3e-9234c706a56f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_adafaba9-44c0-4e08-bbf5-ecc8c63bf676" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_1dce58f2-8bbd-4592-ae3e-9234c706a56f" xlink:to="loc_us-gaap_InterestRateSwapMember_adafaba9-44c0-4e08-bbf5-ecc8c63bf676" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_c368b575-af1c-4ae2-af0d-4421364f18bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_c368b575-af1c-4ae2-af0d-4421364f18bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_96b7f5a7-a020-4018-a28c-003d0e5e3b9b" xlink:to="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_95fa0a0d-6a40-475a-b981-8a33cb63ab90" xlink:href="agnc-20220930.xsd#agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_95fa0a0d-6a40-475a-b981-8a33cb63ab90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GainLossOnOtherDebt_1efc1596-67b1-447d-9962-b1f1fe5796a2" xlink:href="agnc-20220930.xsd#agnc_GainLossOnOtherDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_GainLossOnOtherDebt_1efc1596-67b1-447d-9962-b1f1fe5796a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_03b840ca-34c8-425a-a69f-c473de39f259" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_03b840ca-34c8-425a-a69f-c473de39f259" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_e63acf41-014c-475f-8f98-8e55438d36c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_e63acf41-014c-475f-8f98-8e55438d36c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_c36babdf-fca4-46d2-9042-bd4c8b627df3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_c36babdf-fca4-46d2-9042-bd4c8b627df3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_4b7bc5a4-ed78-4f17-ade8-3063b9f196d5" xlink:href="agnc-20220930.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_4b7bc5a4-ed78-4f17-ade8-3063b9f196d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OptionsAtCost_351cd2b6-b613-41b5-ae92-7bb82e876900" xlink:href="agnc-20220930.xsd#agnc_OptionsAtCost"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_OptionsAtCost_351cd2b6-b613-41b5-ae92-7bb82e876900" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_1271aa95-471a-4dd3-91ed-8c15e33a4524" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_1271aa95-471a-4dd3-91ed-8c15e33a4524" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_2c9d2db8-5be2-4429-8c66-6b4dfbdfe981" xlink:href="agnc-20220930.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_2c9d2db8-5be2-4429-8c66-6b4dfbdfe981" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageVariableInterestRate_09eb4a35-4e27-494f-94bf-a196a92efa6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageVariableInterestRate"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_us-gaap_DerivativeAverageVariableInterestRate_09eb4a35-4e27-494f-94bf-a196a92efa6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_fb812675-2a0a-4cf3-a5d8-3070936f7cc9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_fb812675-2a0a-4cf3-a5d8-3070936f7cc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageForwardStartDate_eee29c27-732e-4fc6-8035-2e212ca893c8" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageForwardStartDate"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_WeightedAverageForwardStartDate_eee29c27-732e-4fc6-8035-2e212ca893c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_e1db74de-8f1f-4c0b-8f73-2b25658e4f33" xlink:href="agnc-20220930.xsd#agnc_InterestRateSwapsLinkedto3MonthLIBOR"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_e1db74de-8f1f-4c0b-8f73-2b25658e4f33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate_19e0ed40-c7ce-4cb5-849a-f6af0447e765" xlink:href="agnc-20220930.xsd#agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_07a3e800-4efd-4f41-b169-287353d3d626" xlink:to="loc_agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate_19e0ed40-c7ce-4cb5-849a-f6af0447e765" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_aa3c2388-ec49-4dbd-b568-2379744a9ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_aa3c2388-ec49-4dbd-b568-2379744a9ab8" xlink:to="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionAxis_485ed906-4538-4d21-b1b5-2e31a20d884d" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:to="loc_agnc_DerivativePositionAxis_485ed906-4538-4d21-b1b5-2e31a20d884d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionDomain_932a1883-5524-4ddd-8172-20284ce601b9" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_485ed906-4538-4d21-b1b5-2e31a20d884d" xlink:to="loc_agnc_DerivativePositionDomain_932a1883-5524-4ddd-8172-20284ce601b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_d5f1eea3-23cf-459b-9507-f523f958ab9d" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_d5f1eea3-23cf-459b-9507-f523f958ab9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_6a431799-7bba-4a74-9c91-b6c098233098" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_d5f1eea3-23cf-459b-9507-f523f958ab9d" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_6a431799-7bba-4a74-9c91-b6c098233098" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_d5952214-6312-4189-b684-38f8e73b2603" xlink:href="agnc-20220930.xsd#agnc_InterestRateSwapsExcludingForwardStartingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_6a431799-7bba-4a74-9c91-b6c098233098" xlink:to="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_d5952214-6312-4189-b684-38f8e73b2603" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_b34c370d-e972-460a-a6f6-5dd39fa1e4ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_b34c370d-e972-460a-a6f6-5dd39fa1e4ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_406ce729-c0d1-4766-b50f-0c3249d9255f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_b34c370d-e972-460a-a6f6-5dd39fa1e4ab" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_406ce729-c0d1-4766-b50f-0c3249d9255f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_e078fff2-c065-4654-a604-e9c3198eb0d4" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_406ce729-c0d1-4766-b50f-0c3249d9255f" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_e078fff2-c065-4654-a604-e9c3198eb0d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_c4d80681-2558-4328-b73f-da42f150898d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:to="loc_us-gaap_InvestmentTypeAxis_c4d80681-2558-4328-b73f-da42f150898d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_956719c4-456d-4662-80da-fd465720d8dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_c4d80681-2558-4328-b73f-da42f150898d" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_956719c4-456d-4662-80da-fd465720d8dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BermudanMember_4b615e05-3c88-47e6-bc24-f391c5fc273a" xlink:href="agnc-20220930.xsd#agnc_BermudanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_956719c4-456d-4662-80da-fd465720d8dd" xlink:to="loc_agnc_BermudanMember_4b615e05-3c88-47e6-bc24-f391c5fc273a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativesMember_39b30a6c-5b47-4958-92ed-0ae220c6ae6e" xlink:href="agnc-20220930.xsd#agnc_OtherDerivativesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_956719c4-456d-4662-80da-fd465720d8dd" xlink:to="loc_agnc_OtherDerivativesMember_39b30a6c-5b47-4958-92ed-0ae220c6ae6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesByMaturityAxis_c738bb26-3cf2-4dbc-a6b2-76b1ed2f4af8" xlink:href="agnc-20220930.xsd#agnc_DerivativesByMaturityAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:to="loc_agnc_DerivativesByMaturityAxis_c738bb26-3cf2-4dbc-a6b2-76b1ed2f4af8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesByMaturityDomain_d6a52e69-d098-4aa4-bf62-4479915b9a10" xlink:href="agnc-20220930.xsd#agnc_DerivativesByMaturityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_c738bb26-3cf2-4dbc-a6b2-76b1ed2f4af8" xlink:to="loc_agnc_DerivativesByMaturityDomain_d6a52e69-d098-4aa4-bf62-4479915b9a10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_489bb66b-47d0-4140-b545-2f39c56e5ac6" xlink:href="agnc-20220930.xsd#agnc_LessThanOrEqualToOneYearMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d6a52e69-d098-4aa4-bf62-4479915b9a10" xlink:to="loc_agnc_LessThanOrEqualToOneYearMember_489bb66b-47d0-4140-b545-2f39c56e5ac6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_b18030fb-c14f-47ee-b8f0-7f09437d9155" xlink:href="agnc-20220930.xsd#agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_d6a52e69-d098-4aa4-bf62-4479915b9a10" xlink:to="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_b18030fb-c14f-47ee-b8f0-7f09437d9155" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_ce7aa1b4-51b3-4af2-8a11-1853be4af7ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_ce7aa1b4-51b3-4af2-8a11-1853be4af7ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_e4d7e295-c748-43ec-a423-fb397e066aa1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ce7aa1b4-51b3-4af2-8a11-1853be4af7ac" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_e4d7e295-c748-43ec-a423-fb397e066aa1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForwardContractsMember_95d95d33-d6b0-410e-a57f-d1d0e9f7f27f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForwardContractsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4d7e295-c748-43ec-a423-fb397e066aa1" xlink:to="loc_us-gaap_ForwardContractsMember_95d95d33-d6b0-410e-a57f-d1d0e9f7f27f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwaptionMember_ca41d032-6f60-42a1-a391-8d41164b0d4a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwaptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4d7e295-c748-43ec-a423-fb397e066aa1" xlink:to="loc_us-gaap_InterestRateSwaptionMember_ca41d032-6f60-42a1-a391-8d41164b0d4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PayerSwaptionMember_b416e39a-06b0-42d3-a6ab-9d10eed50d05" xlink:href="agnc-20220930.xsd#agnc_PayerSwaptionMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4d7e295-c748-43ec-a423-fb397e066aa1" xlink:to="loc_agnc_PayerSwaptionMember_b416e39a-06b0-42d3-a6ab-9d10eed50d05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_981f0f7a-95d2-4e02-a052-6d791640167e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4d7e295-c748-43ec-a423-fb397e066aa1" xlink:to="loc_us-gaap_InterestRateSwapMember_981f0f7a-95d2-4e02-a052-6d791640167e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_b9c70541-8051-47ee-82c8-d24d288941db" xlink:to="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_82f2534c-3d1c-4d99-9c74-f57d106cc919" xlink:href="agnc-20220930.xsd#agnc_InterestRateSwapsLinkedto3MonthLIBOR"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_82f2534c-3d1c-4d99-9c74-f57d106cc919" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageForwardStartDate_686abcee-65ad-4c37-8ac6-9aeb4aef88a6" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageForwardStartDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_agnc_WeightedAverageForwardStartDate_686abcee-65ad-4c37-8ac6-9aeb4aef88a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_1f8f7fa7-e643-4a9a-9472-163468aea7f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_1f8f7fa7-e643-4a9a-9472-163468aea7f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OptionsAtCost_0661c0be-e954-4b9c-8a95-22a395a2f49c" xlink:href="agnc-20220930.xsd#agnc_OptionsAtCost"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_agnc_OptionsAtCost_0661c0be-e954-4b9c-8a95-22a395a2f49c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_2c7c5d35-2187-4b91-b123-45a85d32a0f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_2c7c5d35-2187-4b91-b123-45a85d32a0f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_bb658d99-afad-4ed2-a0c9-010dbc31a991" xlink:href="agnc-20220930.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_bb658d99-afad-4ed2-a0c9-010dbc31a991" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_f8313d2b-4737-4ce1-83c0-5d4792c02fe0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_f8313d2b-4737-4ce1-83c0-5d4792c02fe0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_a6554970-6703-4105-9fb1-c49a7d768d57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_a6554970-6703-4105-9fb1-c49a7d768d57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_00044792-90bf-4a11-bf77-474821413688" xlink:href="agnc-20220930.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_00044792-90bf-4a11-bf77-474821413688" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_49108845-0fe1-4b28-b964-d81493206368" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_49108845-0fe1-4b28-b964-d81493206368" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_57160d2b-3168-47b8-8e9d-ccd7869cd588" xlink:href="agnc-20220930.xsd#agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_73caf212-1423-4d18-b500-6d79d16b82bb" xlink:to="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_57160d2b-3168-47b8-8e9d-ccd7869cd588" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsUSTreasurySecuritiesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsUSTreasurySecuritiesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsUSTreasurySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_fd82bf76-faaa-4146-87f1-5c2a1b244bfb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_fd82bf76-faaa-4146-87f1-5c2a1b244bfb" xlink:to="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_0d702788-87b9-46b4-a476-26b94b011ca5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_us-gaap_InvestmentTypeAxis_0d702788-87b9-46b4-a476-26b94b011ca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_05488372-cf9d-4e94-b053-bbde5176df23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_0d702788-87b9-46b4-a476-26b94b011ca5" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_05488372-cf9d-4e94-b053-bbde5176df23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_6c58e266-2fc5-4a8a-bdeb-458235297dcd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_05488372-cf9d-4e94-b053-bbde5176df23" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_6c58e266-2fc5-4a8a-bdeb-458235297dcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_0d83f76e-14b2-4de1-a237-7a0cdbbacd80" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_0d83f76e-14b2-4de1-a237-7a0cdbbacd80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_6bece8b8-6f60-44b1-9859-608949f4d54a" xlink:href="agnc-20220930.xsd#agnc_DerivativeInstrumentsDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_0d83f76e-14b2-4de1-a237-7a0cdbbacd80" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_6bece8b8-6f60-44b1-9859-608949f4d54a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AtCostBasisMember_683e5cdc-b715-46f6-b3da-f9d0c7a1aa77" xlink:href="agnc-20220930.xsd#agnc_AtCostBasisMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_6bece8b8-6f60-44b1-9859-608949f4d54a" xlink:to="loc_agnc_AtCostBasisMember_683e5cdc-b715-46f6-b3da-f9d0c7a1aa77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_372bc7c4-76b6-4135-bc89-04fc307158b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_372bc7c4-76b6-4135-bc89-04fc307158b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_80eab3fe-5697-4aab-8430-d4f5fbf220b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_372bc7c4-76b6-4135-bc89-04fc307158b6" xlink:to="loc_us-gaap_HedgingRelationshipDomain_80eab3fe-5697-4aab-8430-d4f5fbf220b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_f771b146-70cc-425d-93ff-1973098ab627" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueHedgingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingRelationshipDomain_80eab3fe-5697-4aab-8430-d4f5fbf220b2" xlink:to="loc_us-gaap_FairValueHedgingMember_f771b146-70cc-425d-93ff-1973098ab627" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_184dca08-1ac5-4d34-80ed-888611b7e24f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_us-gaap_PositionAxis_184dca08-1ac5-4d34-80ed-888611b7e24f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_d7632aa3-c83f-4d2f-ae34-70b3ae92ffdd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_184dca08-1ac5-4d34-80ed-888611b7e24f" xlink:to="loc_us-gaap_PositionDomain_d7632aa3-c83f-4d2f-ae34-70b3ae92ffdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_aafe93ed-de04-44c0-9ebd-955238ed2c66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_d7632aa3-c83f-4d2f-ae34-70b3ae92ffdd" xlink:to="loc_us-gaap_ShortMember_aafe93ed-de04-44c0-9ebd-955238ed2c66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember_b766f146-63c4-41a5-b547-6f66f450dcde" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_d7632aa3-c83f-4d2f-ae34-70b3ae92ffdd" xlink:to="loc_us-gaap_LongMember_b766f146-63c4-41a5-b547-6f66f450dcde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesByMaturityAxis_782aaa30-9039-4445-86a5-01fa88332f62" xlink:href="agnc-20220930.xsd#agnc_DerivativesByMaturityAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_agnc_DerivativesByMaturityAxis_782aaa30-9039-4445-86a5-01fa88332f62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesByMaturityDomain_4b51c81d-8ab4-4fbe-9868-9e5703364c16" xlink:href="agnc-20220930.xsd#agnc_DerivativesByMaturityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_782aaa30-9039-4445-86a5-01fa88332f62" xlink:to="loc_agnc_DerivativesByMaturityDomain_4b51c81d-8ab4-4fbe-9868-9e5703364c16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A10YearMaturityMember_015f3076-df53-47d1-b403-34b60c8a6fab" xlink:href="agnc-20220930.xsd#agnc_A10YearMaturityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_4b51c81d-8ab4-4fbe-9868-9e5703364c16" xlink:to="loc_agnc_A10YearMaturityMember_015f3076-df53-47d1-b403-34b60c8a6fab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A5YearMaturityMember_422e5ab6-505a-435d-bef3-61767a64315e" xlink:href="agnc-20220930.xsd#agnc_A5YearMaturityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_4b51c81d-8ab4-4fbe-9868-9e5703364c16" xlink:to="loc_agnc_A5YearMaturityMember_422e5ab6-505a-435d-bef3-61767a64315e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionAxis_69e4cd14-ce30-48e3-a494-06652505512a" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_agnc_DerivativePositionAxis_69e4cd14-ce30-48e3-a494-06652505512a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionDomain_0162f87d-49ef-4459-ba69-5267c320be20" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_69e4cd14-ce30-48e3-a494-06652505512a" xlink:to="loc_agnc_DerivativePositionDomain_0162f87d-49ef-4459-ba69-5267c320be20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A2.5CouponMember_3cc25958-dda5-4057-914c-6622e59dee81" xlink:href="agnc-20220930.xsd#agnc_A2.5CouponMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_0162f87d-49ef-4459-ba69-5267c320be20" xlink:to="loc_agnc_A2.5CouponMember_3cc25958-dda5-4057-914c-6622e59dee81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_24b756bd-83e6-46e3-ba87-d427bc63b59c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_24b756bd-83e6-46e3-ba87-d427bc63b59c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_24b756bd-83e6-46e3-ba87-d427bc63b59c" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A7YearsMaturityMember_279edb06-49b6-4df0-8918-a646ae43382f" xlink:href="agnc-20220930.xsd#agnc_A7YearsMaturityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_A7YearsMaturityMember_279edb06-49b6-4df0-8918-a646ae43382f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_b30ff005-2980-44be-a5ab-5d3004024d26" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_us-gaap_FutureMember_b30ff005-2980-44be-a5ab-5d3004024d26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A15YearMaturityMember_1567beb1-a32f-4ade-95d0-36a6e67a3e6c" xlink:href="agnc-20220930.xsd#agnc_A15YearMaturityMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_A15YearMaturityMember_1567beb1-a32f-4ade-95d0-36a6e67a3e6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AtParValueMember_b525aa17-35e2-4469-8fa5-d5366d554cb9" xlink:href="agnc-20220930.xsd#agnc_AtParValueMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_AtParValueMember_b525aa17-35e2-4469-8fa5-d5366d554cb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AtCostBasisMember_d68d2f69-4da4-4207-9a4d-714f5542a88a" xlink:href="agnc-20220930.xsd#agnc_AtCostBasisMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_AtCostBasisMember_d68d2f69-4da4-4207-9a4d-714f5542a88a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_e11d759f-15c4-41f2-9644-ad170fac4c4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_e11d759f-15c4-41f2-9644-ad170fac4c4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_8ed731b2-31c3-4d7d-a2ac-de57c819c5c4" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_8ed731b2-31c3-4d7d-a2ac-de57c819c5c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A5YearMaturityMember_efc69110-98d4-464c-a0b5-f3e108c79a45" xlink:href="agnc-20220930.xsd#agnc_A5YearMaturityMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_A5YearMaturityMember_efc69110-98d4-464c-a0b5-f3e108c79a45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A10YearMaturityMember_df20d04d-211a-4303-8369-d823944ea563" xlink:href="agnc-20220930.xsd#agnc_A10YearMaturityMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_A10YearMaturityMember_df20d04d-211a-4303-8369-d823944ea563" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A20YearMaturityMember_b2ccc58e-852c-4ae8-a566-94e8dd80a7de" xlink:href="agnc-20220930.xsd#agnc_A20YearMaturityMember"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_369ea088-31dc-426c-b304-f76531c1b2e8" xlink:to="loc_agnc_A20YearMaturityMember_b2ccc58e-852c-4ae8-a566-94e8dd80a7de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_b8b25817-3d41-453c-acb8-27512f5b84c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_us-gaap_FinancialInstrumentAxis_b8b25817-3d41-453c-acb8-27512f5b84c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_21b7ae73-0030-4064-9486-e1721b52af5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_b8b25817-3d41-453c-acb8-27512f5b84c7" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_21b7ae73-0030-4064-9486-e1721b52af5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_9bd9ebf1-73e9-449f-bbb2-7af4764876ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_21b7ae73-0030-4064-9486-e1721b52af5b" xlink:to="loc_us-gaap_FutureMember_9bd9ebf1-73e9-449f-bbb2-7af4764876ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_67fd697e-3b12-4f98-8c9c-a0772476bbc7" xlink:to="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_ade41dc7-f4e7-4434-8464-7249538d43db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:to="loc_us-gaap_DerivativeNotionalAmount_ade41dc7-f4e7-4434-8464-7249538d43db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeForwardSettlementValue_249760ea-7142-45b2-acc3-2b621f9136cb" xlink:href="agnc-20220930.xsd#agnc_DerivativeForwardSettlementValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:to="loc_agnc_DerivativeForwardSettlementValue_249760ea-7142-45b2-acc3-2b621f9136cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_908c4d99-b445-492a-9d3e-708870f900a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_908c4d99-b445-492a-9d3e-708870f900a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_3d32b87e-e913-4b9e-acc0-f923cc292dce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_3d32b87e-e913-4b9e-acc0-f923cc292dce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_d6fbbb3c-0473-406f-892b-4a81bf9d5d4a" xlink:href="agnc-20220930.xsd#agnc_Governmentbondsownedandsoldshortnet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:to="loc_agnc_Governmentbondsownedandsoldshortnet_d6fbbb3c-0473-406f-892b-4a81bf9d5d4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageYieldPercentage_303c83d2-bcfa-40be-a8b0-b666d14e5c99" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageYieldPercentage"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_e52c8620-6b06-48d8-a5ad-c5e055ed73a7" xlink:to="loc_agnc_WeightedAverageYieldPercentage_303c83d2-bcfa-40be-a8b0-b666d14e5c99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTBASecuritiesbyCouponandIssuerDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsTBASecuritiesbyCouponandIssuerDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsTBASecuritiesbyCouponandIssuerDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_ae20f49e-5042-4c7e-988e-d5ff5d7a98a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_ae20f49e-5042-4c7e-988e-d5ff5d7a98a1" xlink:to="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeByMaturityYearsAxis_04494bfd-1f4f-49c2-96f6-55c265c87b1e" xlink:href="agnc-20220930.xsd#agnc_DerivativeByMaturityYearsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:to="loc_agnc_DerivativeByMaturityYearsAxis_04494bfd-1f4f-49c2-96f6-55c265c87b1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeByMaturityYearsDomain_0920cee8-0cf4-4505-adb0-68856bc76fc1" xlink:href="agnc-20220930.xsd#agnc_DerivativeByMaturityYearsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsAxis_04494bfd-1f4f-49c2-96f6-55c265c87b1e" xlink:to="loc_agnc_DerivativeByMaturityYearsDomain_0920cee8-0cf4-4505-adb0-68856bc76fc1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A30YearMaturityMember_bc345c4e-a6ed-4128-ab90-0ae3b28b264d" xlink:href="agnc-20220930.xsd#agnc_A30YearMaturityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain_0920cee8-0cf4-4505-adb0-68856bc76fc1" xlink:to="loc_agnc_A30YearMaturityMember_bc345c4e-a6ed-4128-ab90-0ae3b28b264d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A15YearMaturityMember_843786b8-225a-4045-b675-defcec30842c" xlink:href="agnc-20220930.xsd#agnc_A15YearMaturityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain_0920cee8-0cf4-4505-adb0-68856bc76fc1" xlink:to="loc_agnc_A15YearMaturityMember_843786b8-225a-4045-b675-defcec30842c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesbyIssuerAxis_b3847ff3-3cd5-4a9c-8292-1310b7ff39e7" xlink:href="agnc-20220930.xsd#agnc_DerivativesbyIssuerAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:to="loc_agnc_DerivativesbyIssuerAxis_b3847ff3-3cd5-4a9c-8292-1310b7ff39e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativesbyIssuerDomain_81664473-86e3-422a-8025-0caffb4907e9" xlink:href="agnc-20220930.xsd#agnc_DerivativesbyIssuerDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerAxis_b3847ff3-3cd5-4a9c-8292-1310b7ff39e7" xlink:to="loc_agnc_DerivativesbyIssuerDomain_81664473-86e3-422a-8025-0caffb4907e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_5498033f-4ea3-435b-aa80-714703bfd905" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_81664473-86e3-422a-8025-0caffb4907e9" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_5498033f-4ea3-435b-aa80-714703bfd905" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_0f39320c-bb1d-481f-bf8c-22e62b9886fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_81664473-86e3-422a-8025-0caffb4907e9" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_0f39320c-bb1d-481f-bf8c-22e62b9886fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_34a67efe-0c13-409c-84fd-6e74ac6af1e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_81664473-86e3-422a-8025-0caffb4907e9" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_34a67efe-0c13-409c-84fd-6e74ac6af1e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_c38bbcea-9817-40b8-abf6-26358d6cecb1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:to="loc_us-gaap_PositionAxis_c38bbcea-9817-40b8-abf6-26358d6cecb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_960972b5-6209-477a-98e1-51e0dad9eca8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_c38bbcea-9817-40b8-abf6-26358d6cecb1" xlink:to="loc_us-gaap_PositionDomain_960972b5-6209-477a-98e1-51e0dad9eca8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_d94a8f0a-8ae8-4602-890e-60fea7955050" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_960972b5-6209-477a-98e1-51e0dad9eca8" xlink:to="loc_us-gaap_ShortMember_d94a8f0a-8ae8-4602-890e-60fea7955050" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionAxis_13462ee7-349a-40bb-a704-526354dc51e7" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:to="loc_agnc_DerivativePositionAxis_13462ee7-349a-40bb-a704-526354dc51e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:href="agnc-20220930.xsd#agnc_DerivativePositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_13462ee7-349a-40bb-a704-526354dc51e7" xlink:to="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A20CouponMember_4088d38c-cd58-4443-a40c-08aa68dbb939" xlink:href="agnc-20220930.xsd#agnc_A20CouponMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:to="loc_agnc_A20CouponMember_4088d38c-cd58-4443-a40c-08aa68dbb939" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A2.5CouponMember_da365a65-9cd6-4a67-acb9-da1219f71758" xlink:href="agnc-20220930.xsd#agnc_A2.5CouponMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:to="loc_agnc_A2.5CouponMember_da365a65-9cd6-4a67-acb9-da1219f71758" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A3.0CouponMember_d21ce77a-0bc8-418a-8d49-743609d125e6" xlink:href="agnc-20220930.xsd#agnc_A3.0CouponMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:to="loc_agnc_A3.0CouponMember_d21ce77a-0bc8-418a-8d49-743609d125e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A3.5CouponMember_eba2a98c-efa3-4e15-8ad4-ea8e100813d0" xlink:href="agnc-20220930.xsd#agnc_A3.5CouponMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:to="loc_agnc_A3.5CouponMember_eba2a98c-efa3-4e15-8ad4-ea8e100813d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A4.0CouponMember_8886e8b3-1089-4d09-9b1c-8f4084c79161" xlink:href="agnc-20220930.xsd#agnc_A4.0CouponMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:to="loc_agnc_A4.0CouponMember_8886e8b3-1089-4d09-9b1c-8f4084c79161" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A4.5CouponMember_cfbd1320-fd7d-4e58-83ae-eeb343a5fa69" xlink:href="agnc-20220930.xsd#agnc_A4.5CouponMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:to="loc_agnc_A4.5CouponMember_cfbd1320-fd7d-4e58-83ae-eeb343a5fa69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A3040CouponsMember_f1bd3b6b-c0ed-4341-bbc8-2be9d4a80dc6" xlink:href="agnc-20220930.xsd#agnc_A3040CouponsMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_d64b8861-5932-43a4-846a-129a97d8715e" xlink:to="loc_agnc_A3040CouponsMember_f1bd3b6b-c0ed-4341-bbc8-2be9d4a80dc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_47407552-2cd1-47ef-856a-210261788a4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_47407552-2cd1-47ef-856a-210261788a4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_47407552-2cd1-47ef-856a-210261788a4e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_42b6034a-7495-4b66-89d3-3c502ff0c042" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_42b6034a-7495-4b66-89d3-3c502ff0c042" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A15YearMaturityMember_c8b56774-095b-43e6-900a-f8607046a31a" xlink:href="agnc-20220930.xsd#agnc_A15YearMaturityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:to="loc_agnc_A15YearMaturityMember_c8b56774-095b-43e6-900a-f8607046a31a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A30YearMaturityMember_cf858a0d-58d7-41f0-8817-8fb67e5521d2" xlink:href="agnc-20220930.xsd#agnc_A30YearMaturityMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:to="loc_agnc_A30YearMaturityMember_cf858a0d-58d7-41f0-8817-8fb67e5521d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_a91faa8b-dce1-4cd2-af16-65b24218e3fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_a91faa8b-dce1-4cd2-af16-65b24218e3fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_19528acf-482b-4436-88c8-3bff3fb20ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_19528acf-482b-4436-88c8-3bff3fb20ffa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_a224dcb6-416c-4754-87a3-15690286d257" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_a224dcb6-416c-4754-87a3-15690286d257" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ForwardSettlingNonAgencySecuritiesMember_a5693266-39a8-404f-822c-9ddc08c25af4" xlink:href="agnc-20220930.xsd#agnc_ForwardSettlingNonAgencySecuritiesMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e4a6d9cd-9a24-4ba2-8d0e-47b0953d18b4" xlink:to="loc_agnc_ForwardSettlingNonAgencySecuritiesMember_a5693266-39a8-404f-822c-9ddc08c25af4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_6c00fe38-0f0b-4440-935a-dc4f8c1b95b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_296833b0-5014-402e-be57-42f3ef335f6d" xlink:to="loc_us-gaap_DerivativeLineItems_6c00fe38-0f0b-4440-935a-dc4f8c1b95b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_a53b9132-52df-4936-8b71-7501319e83c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_6c00fe38-0f0b-4440-935a-dc4f8c1b95b6" xlink:to="loc_us-gaap_DerivativeNotionalAmount_a53b9132-52df-4936-8b71-7501319e83c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeForwardSettlementValue_becfcab7-cc44-49a6-b13b-82a83e9904a3" xlink:href="agnc-20220930.xsd#agnc_DerivativeForwardSettlementValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_6c00fe38-0f0b-4440-935a-dc4f8c1b95b6" xlink:to="loc_agnc_DerivativeForwardSettlementValue_becfcab7-cc44-49a6-b13b-82a83e9904a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_ca573c83-a68e-4a77-a787-f0708bc1c22c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_6c00fe38-0f0b-4440-935a-dc4f8c1b95b6" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_ca573c83-a68e-4a77-a787-f0708bc1c22c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_1da4e11b-567a-4eb0-bc0e-73998afe15dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_6c00fe38-0f0b-4440-935a-dc4f8c1b95b6" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_1da4e11b-567a-4eb0-bc0e-73998afe15dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#DerivativeandOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeandOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_cf1962bc-0cee-4a38-9741-c8fa0b7921e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_cf1962bc-0cee-4a38-9741-c8fa0b7921e2" xlink:to="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_fa0456e3-0e96-42fc-be5c-c3acc987af39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_FinancialInstrumentAxis_fa0456e3-0e96-42fc-be5c-c3acc987af39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_69acece4-edcb-42ce-b9f7-d195d2ff4410" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_fa0456e3-0e96-42fc-be5c-c3acc987af39" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_69acece4-edcb-42ce-b9f7-d195d2ff4410" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_e29ca586-5f6f-4437-a118-2fd81911a336" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_69acece4-edcb-42ce-b9f7-d195d2ff4410" xlink:to="loc_us-gaap_FutureMember_e29ca586-5f6f-4437-a118-2fd81911a336" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_ca201b43-5380-4bc9-8077-0a2169f42ada" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_PositionAxis_ca201b43-5380-4bc9-8077-0a2169f42ada" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_edf9f4f8-dc90-4bfb-b514-10d6510c1945" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PositionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_ca201b43-5380-4bc9-8077-0a2169f42ada" xlink:to="loc_us-gaap_PositionDomain_edf9f4f8-dc90-4bfb-b514-10d6510c1945" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_a20f099c-960c-480a-98b8-268b85ef789b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_edf9f4f8-dc90-4bfb-b514-10d6510c1945" xlink:to="loc_us-gaap_ShortMember_a20f099c-960c-480a-98b8-268b85ef789b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember_146bd902-0fff-484f-8d7f-989b56457897" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_edf9f4f8-dc90-4bfb-b514-10d6510c1945" xlink:to="loc_us-gaap_LongMember_146bd902-0fff-484f-8d7f-989b56457897" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_7683ba9a-ff7b-4a8c-badf-03823a67b965" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_HedgingDesignationAxis_7683ba9a-ff7b-4a8c-badf-03823a67b965" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_af9b617b-f042-4d4d-8210-3a6a2a2f5e55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_7683ba9a-ff7b-4a8c-badf-03823a67b965" xlink:to="loc_us-gaap_HedgingDesignationDomain_af9b617b-f042-4d4d-8210-3a6a2a2f5e55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_44c67576-1b36-4201-968d-ec4d9f6c370a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_af9b617b-f042-4d4d-8210-3a6a2a2f5e55" xlink:to="loc_us-gaap_NondesignatedMember_44c67576-1b36-4201-968d-ec4d9f6c370a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_4cc7c30d-3ab0-4f6c-8a78-197c9afeca8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_InvestmentTypeAxis_4cc7c30d-3ab0-4f6c-8a78-197c9afeca8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_8baa5f31-23fb-4785-bfa7-8bab9b46ba1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_4cc7c30d-3ab0-4f6c-8a78-197c9afeca8b" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_8baa5f31-23fb-4785-bfa7-8bab9b46ba1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativesMember_20a710ee-1685-40a3-81a3-25e5466c68b2" xlink:href="agnc-20220930.xsd#agnc_OtherDerivativesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_8baa5f31-23fb-4785-bfa7-8bab9b46ba1e" xlink:to="loc_agnc_OtherDerivativesMember_20a710ee-1685-40a3-81a3-25e5466c68b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_9432d583-60d7-4cc6-8269-e990a578d944" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_8baa5f31-23fb-4785-bfa7-8bab9b46ba1e" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_9432d583-60d7-4cc6-8269-e990a578d944" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_722fe991-4f80-470e-b55e-5b42f70ea903" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_722fe991-4f80-470e-b55e-5b42f70ea903" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_722fe991-4f80-470e-b55e-5b42f70ea903" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestrateswapreceiverMember_e8b2928d-f16e-4fff-9a37-45fba60fbf26" xlink:href="agnc-20220930.xsd#agnc_InterestrateswapreceiverMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_agnc_InterestrateswapreceiverMember_e8b2928d-f16e-4fff-9a37-45fba60fbf26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PayerSwaptionMember_a8d7663d-c5f4-483e-a21d-320329ab5bef" xlink:href="agnc-20220930.xsd#agnc_PayerSwaptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_agnc_PayerSwaptionMember_a8d7663d-c5f4-483e-a21d-320329ab5bef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_0ea2616c-bead-4507-ae1a-a82b044310f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_us-gaap_FutureMember_0ea2616c-bead-4507-ae1a-a82b044310f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwaptionMember_da4424ed-120c-4db6-aebe-0fe41e29223c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwaptionMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_us-gaap_InterestRateSwaptionMember_da4424ed-120c-4db6-aebe-0fe41e29223c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_3efa57b8-130f-4935-92b8-0f1cdf9d161a" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_3efa57b8-130f-4935-92b8-0f1cdf9d161a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_dc803df7-6eb7-4a1c-8ff1-fb0701f18b2f" xlink:href="agnc-20220930.xsd#agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_dc803df7-6eb7-4a1c-8ff1-fb0701f18b2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_17e0dc88-c0bd-4e80-8dc2-607614aa711d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_us-gaap_InterestRateSwapMember_17e0dc88-c0bd-4e80-8dc2-607614aa711d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_b53e8391-4989-44cf-8abf-bc0251225bfe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_b53e8391-4989-44cf-8abf-bc0251225bfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceiverSwaptionMember_697a444d-e993-42a4-93bf-c04a76ea327f" xlink:href="agnc-20220930.xsd#agnc_ReceiverSwaptionMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_agnc_ReceiverSwaptionMember_697a444d-e993-42a4-93bf-c04a76ea327f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ForwardSettlingNonAgencySecuritiesMember_cb6570e4-ab19-481b-bb99-ccebdc2ec62c" xlink:href="agnc-20220930.xsd#agnc_ForwardSettlingNonAgencySecuritiesMember"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_agnc_ForwardSettlingNonAgencySecuritiesMember_cb6570e4-ab19-481b-bb99-ccebdc2ec62c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember_67019643-d9c5-492c-941f-a411705bf48e" xlink:href="agnc-20220930.xsd#agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember_67019643-d9c5-492c-941f-a411705bf48e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditDefaultSwapMember_1d4b3e1a-f1c5-49b3-a35b-95c30c1a4ebc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditDefaultSwapMember"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_us-gaap_CreditDefaultSwapMember_1d4b3e1a-f1c5-49b3-a35b-95c30c1a4ebc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditDefaultSwapBuyingProtectionMember_022d86a0-83d3-45a8-9118-1c03e57d7103" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditDefaultSwapBuyingProtectionMember"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b3c44f0d-2f1c-4ef5-9b99-033f9fa40dab" xlink:to="loc_us-gaap_CreditDefaultSwapBuyingProtectionMember_022d86a0-83d3-45a8-9118-1c03e57d7103" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_a1d84f4d-84fa-481a-80c0-cff5cceda47c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_a1d84f4d-84fa-481a-80c0-cff5cceda47c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_38b4cc57-66a0-4aa3-8674-35116a6105e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_a1d84f4d-84fa-481a-80c0-cff5cceda47c" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_38b4cc57-66a0-4aa3-8674-35116a6105e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_9bda6404-a017-4dbb-9b40-509f5350d4ff" xlink:href="agnc-20220930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_38b4cc57-66a0-4aa3-8674-35116a6105e9" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_9bda6404-a017-4dbb-9b40-509f5350d4ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_40bd4991-7c81-49df-af9c-909aae1a72fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_38b4cc57-66a0-4aa3-8674-35116a6105e9" xlink:to="loc_us-gaap_InterestRateSwapMember_40bd4991-7c81-49df-af9c-909aae1a72fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_3b0a31ed-798a-4f4e-b95f-51b881ac70ed" xlink:href="agnc-20220930.xsd#agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_38b4cc57-66a0-4aa3-8674-35116a6105e9" xlink:to="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_3b0a31ed-798a-4f4e-b95f-51b881ac70ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_847c53a3-be89-4dfb-a7ac-5a8d1027e2a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_38b4cc57-66a0-4aa3-8674-35116a6105e9" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_847c53a3-be89-4dfb-a7ac-5a8d1027e2a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_33072fea-dff8-44bd-bd67-9b3cd206c964" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_33072fea-dff8-44bd-bd67-9b3cd206c964" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_eacb60bb-302d-493b-b77d-441e59ff3da7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_33072fea-dff8-44bd-bd67-9b3cd206c964" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_eacb60bb-302d-493b-b77d-441e59ff3da7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1b206fe0-03e7-44cf-99f4-703481cc0f51" xlink:to="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_158b3cfc-4a3e-4c46-93a7-33c7463fe25d" xlink:href="agnc-20220930.xsd#agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:to="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_158b3cfc-4a3e-4c46-93a7-33c7463fe25d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_41bdbf35-cf8e-4e6c-8873-97428e3d9820" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_158b3cfc-4a3e-4c46-93a7-33c7463fe25d" xlink:to="loc_us-gaap_DerivativeNotionalAmount_41bdbf35-cf8e-4e6c-8873-97428e3d9820" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_70a556f4-3b23-4fe3-be9f-111aafdc4be3" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_158b3cfc-4a3e-4c46-93a7-33c7463fe25d" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_70a556f4-3b23-4fe3-be9f-111aafdc4be3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_8f6b35ca-f294-43ba-b025-88f4980a643b" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_158b3cfc-4a3e-4c46-93a7-33c7463fe25d" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_8f6b35ca-f294-43ba-b025-88f4980a643b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_3c34aaa6-7abe-4de7-8dd5-ddeca806914d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_158b3cfc-4a3e-4c46-93a7-33c7463fe25d" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_3c34aaa6-7abe-4de7-8dd5-ddeca806914d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_91ea0bb8-c1bd-4866-8a19-3da5f0f89d45" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_91ea0bb8-c1bd-4866-8a19-3da5f0f89d45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities_d9434071-ed53-4d96-b7e3-d272223bcb69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:to="loc_us-gaap_TradingSecurities_d9434071-ed53-4d96-b7e3-d272223bcb69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_f6a30ea2-4b7e-4369-96b0-af35859d06aa" xlink:href="agnc-20220930.xsd#agnc_TradingSecuritiesAddedDuringthePeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_f6a30ea2-4b7e-4369-96b0-af35859d06aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_0bbd2ed2-16d4-4a1a-b3df-ac317bb0f43a" xlink:href="agnc-20220930.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_0bbd2ed2-16d4-4a1a-b3df-ac317bb0f43a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GainLossOnOtherDebt_7f99f217-c04b-48f8-a943-da2cc4e27937" xlink:href="agnc-20220930.xsd#agnc_GainLossOnOtherDebt"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:to="loc_agnc_GainLossOnOtherDebt_7f99f217-c04b-48f8-a943-da2cc4e27937" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_c34cdfa4-2483-4534-b1e9-674a4f485866" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6fc72513-a5f4-46e8-b6f6-76637800b639" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_c34cdfa4-2483-4534-b1e9-674a4f485866" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/BalanceSheetOffsettingDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#BalanceSheetOffsettingDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/BalanceSheetOffsettingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_09e26bf6-889f-4b01-a861-62ce7334f8b4" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsAndOtherLiabilitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsTableTextBlock_e8871474-41ca-46c7-ab38-682fe6243e25" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_09e26bf6-889f-4b01-a861-62ce7334f8b4" xlink:to="loc_agnc_OtherAssetsTableTextBlock_e8871474-41ca-46c7-ab38-682fe6243e25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsLineItems_17725959-7ee4-445d-bd5c-449c1e45fa31" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsLineItems"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsTableTextBlock_e8871474-41ca-46c7-ab38-682fe6243e25" xlink:to="loc_agnc_OtherAssetsLineItems_17725959-7ee4-445d-bd5c-449c1e45fa31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivable_24a9579a-6c6e-4696-ac73-79c8361bdbd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsLineItems_17725959-7ee4-445d-bd5c-449c1e45fa31" xlink:to="loc_us-gaap_InterestReceivable_24a9579a-6c6e-4696-ac73-79c8361bdbd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableForUnsettledTransactions_509f7571-15a1-41a5-8c40-ca85ac40ceb8" xlink:href="agnc-20220930.xsd#agnc_ReceivableForUnsettledTransactions"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsLineItems_17725959-7ee4-445d-bd5c-449c1e45fa31" xlink:to="loc_agnc_ReceivableForUnsettledTransactions_509f7571-15a1-41a5-8c40-ca85ac40ceb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_VentureCapitalInvestments_4cf1df39-ad42-4fa6-b7da-4233288fa0d3" xlink:href="agnc-20220930.xsd#agnc_VentureCapitalInvestments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsLineItems_17725959-7ee4-445d-bd5c-449c1e45fa31" xlink:to="loc_agnc_VentureCapitalInvestments_4cf1df39-ad42-4fa6-b7da-4233288fa0d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsOther_d89163d9-ee9f-4009-be12-177939f5c090" xlink:href="agnc-20220930.xsd#agnc_OtherAssetsOther"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsLineItems_17725959-7ee4-445d-bd5c-449c1e45fa31" xlink:to="loc_agnc_OtherAssetsOther_d89163d9-ee9f-4009-be12-177939f5c090" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_22bc385e-fb82-412a-9f39-acd60ae4c32a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssets"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsLineItems_17725959-7ee4-445d-bd5c-449c1e45fa31" xlink:to="loc_us-gaap_OtherAssets_22bc385e-fb82-412a-9f39-acd60ae4c32a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrentAndNoncurrent_5f281cdd-b1a3-477c-a2d1-da425d7f686d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestPayableCurrentAndNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_09e26bf6-889f-4b01-a861-62ce7334f8b4" xlink:to="loc_us-gaap_InterestPayableCurrentAndNoncurrent_5f281cdd-b1a3-477c-a2d1-da425d7f686d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CashPledgedFromCounterparties_b6289349-804d-462c-b3db-2e9f4653a052" xlink:href="agnc-20220930.xsd#agnc_CashPledgedFromCounterparties"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_09e26bf6-889f-4b01-a861-62ce7334f8b4" xlink:to="loc_agnc_CashPledgedFromCounterparties_b6289349-804d-462c-b3db-2e9f4653a052" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PayableForUnsettledTransactions_d942b108-e1cc-4b11-b537-b80daef3f132" xlink:href="agnc-20220930.xsd#agnc_PayableForUnsettledTransactions"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_09e26bf6-889f-4b01-a861-62ce7334f8b4" xlink:to="loc_agnc_PayableForUnsettledTransactions_d942b108-e1cc-4b11-b537-b80daef3f132" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherLiabilitiesOther_942cadb6-d24e-4269-b5cd-75fd8abfd3aa" xlink:href="agnc-20220930.xsd#agnc_OtherLiabilitiesOther"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_09e26bf6-889f-4b01-a861-62ce7334f8b4" xlink:to="loc_agnc_OtherLiabilitiesOther_942cadb6-d24e-4269-b5cd-75fd8abfd3aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_92356111-a62e-4dc7-8402-a11aae697188" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OtherAssetsAndOtherLiabilitiesAbstract_09e26bf6-889f-4b01-a861-62ce7334f8b4" xlink:to="loc_us-gaap_OtherLiabilities_92356111-a62e-4dc7-8402-a11aae697188" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssetsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_a1d5f3dc-baff-4285-a92f-e663af680261" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_52f876da-c9c7-4b1f-ac2a-08d33799b32d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_a1d5f3dc-baff-4285-a92f-e663af680261" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_52f876da-c9c7-4b1f-ac2a-08d33799b32d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_21fabac1-e642-42c7-bdc9-29c99df3ccd2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditDerivativeMaximumExposureUndiscounted"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_a1d5f3dc-baff-4285-a92f-e663af680261" xlink:to="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_21fabac1-e642-42c7-bdc9-29c99df3ccd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_2045191f-7878-433c-8264-995d468cfec0" xlink:href="agnc-20220930.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_a1d5f3dc-baff-4285-a92f-e663af680261" xlink:to="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_2045191f-7878-433c-8264-995d468cfec0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_52b11965-23f1-4373-9c29-70f43bd43eeb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_a1d5f3dc-baff-4285-a92f-e663af680261" xlink:to="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_52b11965-23f1-4373-9c29-70f43bd43eeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ab6a3185-fcec-419c-bb50-c775071f05b3" xlink:href="agnc-20220930.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_a1d5f3dc-baff-4285-a92f-e663af680261" xlink:to="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_ab6a3185-fcec-419c-bb50-c775071f05b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementswithCounterpartiesGreaterthanorEqualto5ofEquityatRiskDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssetsRepurchaseAgreementswithCounterpartiesGreaterthanorEqualto5ofEquityatRiskDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementswithCounterpartiesGreaterthanorEqualto5ofEquityatRiskDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_c248adbf-99a3-4eb9-8736-4aac9247450b" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_65062a1d-fe8b-403a-b01d-30e05946fc4f" xlink:href="agnc-20220930.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_c248adbf-99a3-4eb9-8736-4aac9247450b" xlink:to="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_65062a1d-fe8b-403a-b01d-30e05946fc4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_84ee6cf4-bd76-468b-93e0-d2d0776bca6c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_65062a1d-fe8b-403a-b01d-30e05946fc4f" xlink:to="loc_srt_CounterpartyNameAxis_84ee6cf4-bd76-468b-93e0-d2d0776bca6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3d677ad8-3561-467b-b0e9-050a02226f65" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_84ee6cf4-bd76-468b-93e0-d2d0776bca6c" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3d677ad8-3561-467b-b0e9-050a02226f65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FICCMember_9610405b-02d2-4081-bbfe-a1f642ee947b" xlink:href="agnc-20220930.xsd#agnc_FICCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3d677ad8-3561-467b-b0e9-050a02226f65" xlink:to="loc_agnc_FICCMember_9610405b-02d2-4081-bbfe-a1f642ee947b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_J.P.MorganSecuritiesLLCMember_bbafc2df-f170-4b7f-8837-dd955aed45d7" xlink:href="agnc-20220930.xsd#agnc_J.P.MorganSecuritiesLLCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3d677ad8-3561-467b-b0e9-050a02226f65" xlink:to="loc_agnc_J.P.MorganSecuritiesLLCMember_bbafc2df-f170-4b7f-8837-dd955aed45d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_33c7bbed-f866-4016-9c49-3cb3ac3c433d" xlink:href="agnc-20220930.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_65062a1d-fe8b-403a-b01d-30e05946fc4f" xlink:to="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_33c7bbed-f866-4016-9c49-3cb3ac3c433d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_c104a627-5bb1-4c12-97c1-8ddd37578bab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_33c7bbed-f866-4016-9c49-3cb3ac3c433d" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_c104a627-5bb1-4c12-97c1-8ddd37578bab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_5ce2f041-2ff7-47a9-8d32-9b0cf246e8a2" xlink:href="agnc-20220930.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_33c7bbed-f866-4016-9c49-3cb3ac3c433d" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_5ce2f041-2ff7-47a9-8d32-9b0cf246e8a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CounterpartyExposureNet_6a231120-b5b9-4f0e-bbb5-296b65c0a466" xlink:href="agnc-20220930.xsd#agnc_CounterpartyExposureNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_33c7bbed-f866-4016-9c49-3cb3ac3c433d" xlink:to="loc_agnc_CounterpartyExposureNet_6a231120-b5b9-4f0e-bbb5-296b65c0a466" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_5dfc5e77-2552-443d-9e97-a4cb0adff0d7" xlink:href="agnc-20220930.xsd#agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_33c7bbed-f866-4016-9c49-3cb3ac3c433d" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_5dfc5e77-2552-443d-9e97-a4cb0adff0d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_7907181e-4240-45b8-b0ef-ca0349c76db0" xlink:href="agnc-20220930.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_33c7bbed-f866-4016-9c49-3cb3ac3c433d" xlink:to="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_7907181e-4240-45b8-b0ef-ca0349c76db0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedasCollateralDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssetsAssetsPledgedasCollateralDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedasCollateralDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_be212173-ba07-4460-8e43-8c11f9eb2ecc" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_a1fe300f-2dec-4cd9-bd12-38c859df8b75" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_be212173-ba07-4460-8e43-8c11f9eb2ecc" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_a1fe300f-2dec-4cd9-bd12-38c859df8b75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e319f381-af6c-4ef7-b527-5b115706d315" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_a1fe300f-2dec-4cd9-bd12-38c859df8b75" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e319f381-af6c-4ef7-b527-5b115706d315" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_c45b4ce2-ee3c-4a61-90dd-54189f0e0c53" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e319f381-af6c-4ef7-b527-5b115706d315" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_c45b4ce2-ee3c-4a61-90dd-54189f0e0c53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_c2ee2160-2c08-4fba-8340-21eb45b00172" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_c45b4ce2-ee3c-4a61-90dd-54189f0e0c53" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_c2ee2160-2c08-4fba-8340-21eb45b00172" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember_9df2bb01-04c1-4477-8a63-444150e1b2af" xlink:href="agnc-20220930.xsd#agnc_UnderPrimeBrokerAgreementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_c45b4ce2-ee3c-4a61-90dd-54189f0e0c53" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_9df2bb01-04c1-4477-8a63-444150e1b2af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ExcludingCashReceivedMember_a6406d15-1038-4b7c-ba7e-0537fa5cee19" xlink:href="agnc-20220930.xsd#agnc_ExcludingCashReceivedMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_c45b4ce2-ee3c-4a61-90dd-54189f0e0c53" xlink:to="loc_agnc_ExcludingCashReceivedMember_a6406d15-1038-4b7c-ba7e-0537fa5cee19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeAgreementsAndOtherMember_36e417b3-0063-413f-9d22-b1e8725ef5a2" xlink:href="agnc-20220930.xsd#agnc_DerivativeAgreementsAndOtherMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_c45b4ce2-ee3c-4a61-90dd-54189f0e0c53" xlink:to="loc_agnc_DerivativeAgreementsAndOtherMember_36e417b3-0063-413f-9d22-b1e8725ef5a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_3c634bb6-a568-4c77-a78e-4bb4dd39cdfe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_a1fe300f-2dec-4cd9-bd12-38c859df8b75" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_3c634bb6-a568-4c77-a78e-4bb4dd39cdfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_3c634bb6-a568-4c77-a78e-4bb4dd39cdfe" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_36c7fac5-83f7-4890-9ba4-eeedf5fe2a0d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_36c7fac5-83f7-4890-9ba4-eeedf5fe2a0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_5d5a3e3f-3f95-49c2-9114-a95ebd7189fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_5d5a3e3f-3f95-49c2-9114-a95ebd7189fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember_f1ba9227-d48b-40d2-86af-e35c91903448" xlink:href="agnc-20220930.xsd#agnc_UnderPrimeBrokerAgreementsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_f1ba9227-d48b-40d2-86af-e35c91903448" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_2fbeeaef-1e20-4dd5-95f1-2c29cf53b0af" xlink:href="agnc-20220930.xsd#agnc_IncludesSoldButNotYetSettledSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_2fbeeaef-1e20-4dd5-95f1-2c29cf53b0af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_f7b45069-76f2-40dd-9523-e3c5fbd1b731" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_f7b45069-76f2-40dd-9523-e3c5fbd1b731" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonAgencyMember_7a10b261-d100-406a-9106-6711273a23c2" xlink:href="agnc-20220930.xsd#agnc_NonAgencyMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_agnc_NonAgencyMember_7a10b261-d100-406a-9106-6711273a23c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_37a29438-636d-426b-a5df-941de6619ae9" xlink:href="agnc-20220930.xsd#agnc_AAANonAgencyMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_37a29438-636d-426b-a5df-941de6619ae9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_08a36dce-7d17-4d62-9419-d0e46cbd6564" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_08a36dce-7d17-4d62-9419-d0e46cbd6564" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeMember_6cad47b6-f2a5-4f9e-b9b2-5269ca3509ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_us-gaap_DerivativeMember_6cad47b6-f2a5-4f9e-b9b2-5269ca3509ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_57d0dd1a-c573-4c41-9c0e-32b51e1a72c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeAgreementsAndOtherMember_70d10c58-8eea-4755-84f8-802a54d6dce6" xlink:href="agnc-20220930.xsd#agnc_DerivativeAgreementsAndOtherMember"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_29bffb4a-f081-483e-8879-4d2195d29dd0" xlink:to="loc_agnc_DerivativeAgreementsAndOtherMember_70d10c58-8eea-4755-84f8-802a54d6dce6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_d7811e32-9ec5-48e6-bd3c-f75f511854df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_a1fe300f-2dec-4cd9-bd12-38c859df8b75" xlink:to="loc_us-gaap_InvestmentTypeAxis_d7811e32-9ec5-48e6-bd3c-f75f511854df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_a99f8175-87df-4d61-bb5a-519dd4f80220" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_d7811e32-9ec5-48e6-bd3c-f75f511854df" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_a99f8175-87df-4d61-bb5a-519dd4f80220" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember_6581ef22-4591-43f2-aa9a-650c0dc16738" xlink:href="agnc-20220930.xsd#agnc_UnderPrimeBrokerAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_a99f8175-87df-4d61-bb5a-519dd4f80220" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_6581ef22-4591-43f2-aa9a-650c0dc16738" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_19450224-de6d-4a31-b9ae-1d2fb31b8ee6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_a99f8175-87df-4d61-bb5a-519dd4f80220" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_19450224-de6d-4a31-b9ae-1d2fb31b8ee6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeMember_aaab9168-7248-4d44-a058-96b7927b6704" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_a99f8175-87df-4d61-bb5a-519dd4f80220" xlink:to="loc_us-gaap_DerivativeMember_aaab9168-7248-4d44-a058-96b7927b6704" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember_f3543966-1132-43a0-b430-d1fa3c1e6c40" xlink:href="agnc-20220930.xsd#agnc_UnderPrimeBrokerAgreementsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeAgreementsAndOtherMember_45035a92-3391-4ce5-b48a-9365bf60b48f" xlink:href="agnc-20220930.xsd#agnc_DerivativeAgreementsAndOtherMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_a99f8175-87df-4d61-bb5a-519dd4f80220" xlink:to="loc_agnc_DerivativeAgreementsAndOtherMember_45035a92-3391-4ce5-b48a-9365bf60b48f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_f60feefb-1211-43a2-b2d3-cc6ef280e2c3" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_a1fe300f-2dec-4cd9-bd12-38c859df8b75" xlink:to="loc_srt_CounterpartyNameAxis_f60feefb-1211-43a2-b2d3-cc6ef280e2c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_06fb5004-f336-41c8-ba5d-951da076c679" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_f60feefb-1211-43a2-b2d3-cc6ef280e2c3" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_06fb5004-f336-41c8-ba5d-951da076c679" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FICCMember_f99e1348-1cc4-4335-8770-11d037f6a3e2" xlink:href="agnc-20220930.xsd#agnc_FICCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_06fb5004-f336-41c8-ba5d-951da076c679" xlink:to="loc_agnc_FICCMember_f99e1348-1cc4-4335-8770-11d037f6a3e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_a1fe300f-2dec-4cd9-bd12-38c859df8b75" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_bce769b0-1415-4929-a9f1-b6c374694ac5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_bce769b0-1415-4929-a9f1-b6c374694ac5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_79845d3e-f705-43b3-b033-7e9608b22c1c" xlink:href="agnc-20220930.xsd#agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:to="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_79845d3e-f705-43b3-b033-7e9608b22c1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_cd0e4427-baf5-446a-85c9-69a4bcf9907b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_cd0e4427-baf5-446a-85c9-69a4bcf9907b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_5448bb4e-7a52-45ca-adf4-b9ef9e3be2da" xlink:href="agnc-20220930.xsd#agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:to="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_5448bb4e-7a52-45ca-adf4-b9ef9e3be2da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_cd4aee68-46ac-45f9-8c8a-1745c7079ca0" xlink:href="agnc-20220930.xsd#agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:to="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_cd4aee68-46ac-45f9-8c8a-1745c7079ca0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue_8e8f6446-30cc-4a4c-8183-290e2c74bc65" xlink:href="agnc-20220930.xsd#agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:to="loc_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue_8e8f6446-30cc-4a4c-8183-290e2c74bc65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_43d54e24-92ba-48fb-8777-ed645c24dcca" xlink:href="agnc-20220930.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_d86e3f2d-37e0-4dd0-912a-24e88ebb1d3c" xlink:to="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_43d54e24-92ba-48fb-8777-ed645c24dcca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedasCollateralDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssetsSecuritiesPledgedasCollateralDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedasCollateralDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_25ba5ab6-a564-41dd-a798-573ad5609f06" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_94c1e94b-6a2d-4ad1-8aa8-02a5b492f80b" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_25ba5ab6-a564-41dd-a798-573ad5609f06" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_94c1e94b-6a2d-4ad1-8aa8-02a5b492f80b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_d4a01db8-8015-4ca7-851d-81751fe682b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_94c1e94b-6a2d-4ad1-8aa8-02a5b492f80b" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_d4a01db8-8015-4ca7-851d-81751fe682b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_b97ae7d2-7033-4f63-be72-343df85cbfcc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_d4a01db8-8015-4ca7-851d-81751fe682b4" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_b97ae7d2-7033-4f63-be72-343df85cbfcc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_56dc87ef-5d2c-4a1e-82d6-cb219cd24e10" xlink:href="agnc-20220930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_b97ae7d2-7033-4f63-be72-343df85cbfcc" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_56dc87ef-5d2c-4a1e-82d6-cb219cd24e10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_35cd1872-ee97-4a86-a4fb-560c597e23c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_b97ae7d2-7033-4f63-be72-343df85cbfcc" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_35cd1872-ee97-4a86-a4fb-560c597e23c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonAgencyMember_5759844a-42a8-4062-8e18-aac3b9f10d81" xlink:href="agnc-20220930.xsd#agnc_NonAgencyMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_b97ae7d2-7033-4f63-be72-343df85cbfcc" xlink:to="loc_agnc_NonAgencyMember_5759844a-42a8-4062-8e18-aac3b9f10d81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_d0b8e629-19dc-4011-93cb-257eaea91891" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_94c1e94b-6a2d-4ad1-8aa8-02a5b492f80b" xlink:to="loc_us-gaap_InvestmentTypeAxis_d0b8e629-19dc-4011-93cb-257eaea91891" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_437f969c-4ba9-44bf-9351-efa66d7e5681" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_d0b8e629-19dc-4011-93cb-257eaea91891" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_437f969c-4ba9-44bf-9351-efa66d7e5681" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_4db19150-88d6-41c7-acd4-ae1689e2af5e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_437f969c-4ba9-44bf-9351-efa66d7e5681" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_4db19150-88d6-41c7-acd4-ae1689e2af5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeMember_a8d92297-1519-4e5f-a3e5-e2d1267215b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_437f969c-4ba9-44bf-9351-efa66d7e5681" xlink:to="loc_us-gaap_DerivativeMember_a8d92297-1519-4e5f-a3e5-e2d1267215b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AgencySecuritiesMember_d7b8c7a6-71f3-4e14-a13e-f8c01cd1dc22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AgencySecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_437f969c-4ba9-44bf-9351-efa66d7e5681" xlink:to="loc_us-gaap_AgencySecuritiesMember_d7b8c7a6-71f3-4e14-a13e-f8c01cd1dc22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_4463669b-e2f7-474f-b93d-3b02f9861e44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_437f969c-4ba9-44bf-9351-efa66d7e5681" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_4463669b-e2f7-474f-b93d-3b02f9861e44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_87b93ae4-0531-43ff-a3c5-4d58071f14a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_94c1e94b-6a2d-4ad1-8aa8-02a5b492f80b" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_87b93ae4-0531-43ff-a3c5-4d58071f14a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_33b93faa-42ef-4c14-8459-8f0ccadec06a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_87b93ae4-0531-43ff-a3c5-4d58071f14a7" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_33b93faa-42ef-4c14-8459-8f0ccadec06a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_615a1e9f-732a-4e70-b185-5a0fd8e4f0f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityUpTo30DaysMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_33b93faa-42ef-4c14-8459-8f0ccadec06a" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_615a1e9f-732a-4e70-b185-5a0fd8e4f0f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Maturity31To59DaysMember_df2e44db-d9a8-45a8-8333-4d8c6297ccd9" xlink:href="agnc-20220930.xsd#agnc_Maturity31To59DaysMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_33b93faa-42ef-4c14-8459-8f0ccadec06a" xlink:to="loc_agnc_Maturity31To59DaysMember_df2e44db-d9a8-45a8-8333-4d8c6297ccd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Maturity60To90DaysMember_fe99e214-ba89-464f-af99-57c5c6526a38" xlink:href="agnc-20220930.xsd#agnc_Maturity60To90DaysMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_33b93faa-42ef-4c14-8459-8f0ccadec06a" xlink:to="loc_agnc_Maturity60To90DaysMember_fe99e214-ba89-464f-af99-57c5c6526a38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityOver90DaysMember_78542fda-b801-4f00-82ce-4a75093bde57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityOver90DaysMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_33b93faa-42ef-4c14-8459-8f0ccadec06a" xlink:to="loc_us-gaap_MaturityOver90DaysMember_78542fda-b801-4f00-82ce-4a75093bde57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A2Daysto1MonthMember_f06afd22-d2fe-4c1c-a009-7291c66ccd2d" xlink:href="agnc-20220930.xsd#agnc_A2Daysto1MonthMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_33b93faa-42ef-4c14-8459-8f0ccadec06a" xlink:to="loc_agnc_A2Daysto1MonthMember_f06afd22-d2fe-4c1c-a009-7291c66ccd2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_fa33de42-862e-4f8f-8695-03f7515a085f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_94c1e94b-6a2d-4ad1-8aa8-02a5b492f80b" xlink:to="loc_srt_CounterpartyNameAxis_fa33de42-862e-4f8f-8695-03f7515a085f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_48c767de-4595-4d7c-8757-678193e18f2c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_fa33de42-862e-4f8f-8695-03f7515a085f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_48c767de-4595-4d7c-8757-678193e18f2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FICCMember_fdeaf944-1a9f-464c-8e8e-9e2b264c32fa" xlink:href="agnc-20220930.xsd#agnc_FICCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_48c767de-4595-4d7c-8757-678193e18f2c" xlink:to="loc_agnc_FICCMember_fdeaf944-1a9f-464c-8e8e-9e2b264c32fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_f551f076-9ab8-4697-9cb8-ae7231dff7f2" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_94c1e94b-6a2d-4ad1-8aa8-02a5b492f80b" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_f551f076-9ab8-4697-9cb8-ae7231dff7f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue_58a77391-7955-411e-87e0-e623e1b50ca5" xlink:href="agnc-20220930.xsd#agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_f551f076-9ab8-4697-9cb8-ae7231dff7f2" xlink:to="loc_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue_58a77391-7955-411e-87e0-e623e1b50ca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_5f6a108f-7246-4c6e-b886-e9df135870ba" xlink:href="agnc-20220930.xsd#agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_f551f076-9ab8-4697-9cb8-ae7231dff7f2" xlink:to="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_5f6a108f-7246-4c6e-b886-e9df135870ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_24e48f17-f300-4b3c-a9db-ed09252c4967" xlink:href="agnc-20220930.xsd#agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_f551f076-9ab8-4697-9cb8-ae7231dff7f2" xlink:to="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_24e48f17-f300-4b3c-a9db-ed09252c4967" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_db158d75-e7f5-4c22-b45c-8891044320d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_f551f076-9ab8-4697-9cb8-ae7231dff7f2" xlink:to="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_db158d75-e7f5-4c22-b45c-8891044320d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedfromCounterpartiesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssetsAssetsPledgedfromCounterpartiesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedfromCounterpartiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_5b36670e-9871-4171-b191-2c37fe0d38ca" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_0e96b35d-b357-4cf8-9611-343c72db87be" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_5b36670e-9871-4171-b191-2c37fe0d38ca" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_0e96b35d-b357-4cf8-9611-343c72db87be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e1501796-1f40-4b3f-8c94-fd0b7672cdf5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_0e96b35d-b357-4cf8-9611-343c72db87be" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e1501796-1f40-4b3f-8c94-fd0b7672cdf5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_46980784-f643-44fa-8fc4-d50f0cca57d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e1501796-1f40-4b3f-8c94-fd0b7672cdf5" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_46980784-f643-44fa-8fc4-d50f0cca57d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeMember_3842e385-21a2-4ed5-8432-1c4e254b3075" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_46980784-f643-44fa-8fc4-d50f0cca57d5" xlink:to="loc_us-gaap_DerivativeMember_3842e385-21a2-4ed5-8432-1c4e254b3075" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_7acfc00c-066e-4980-986f-e6337e2d7beb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_0e96b35d-b357-4cf8-9611-343c72db87be" xlink:to="loc_us-gaap_InvestmentTypeAxis_7acfc00c-066e-4980-986f-e6337e2d7beb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_983c34de-33f8-42dd-9ea3-6f9afff1fdd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_7acfc00c-066e-4980-986f-e6337e2d7beb" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_983c34de-33f8-42dd-9ea3-6f9afff1fdd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_2a7ec840-fd5d-4e81-a27a-92b0feae147e" xlink:href="agnc-20220930.xsd#agnc_ReverseRepurchaseAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_983c34de-33f8-42dd-9ea3-6f9afff1fdd6" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_2a7ec840-fd5d-4e81-a27a-92b0feae147e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeMember_cc194f67-feba-4296-8ab1-511de70c71ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_983c34de-33f8-42dd-9ea3-6f9afff1fdd6" xlink:to="loc_us-gaap_DerivativeMember_cc194f67-feba-4296-8ab1-511de70c71ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_0764ed7b-5609-41c6-a1d8-edf7c5244e11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_0e96b35d-b357-4cf8-9611-343c72db87be" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_0764ed7b-5609-41c6-a1d8-edf7c5244e11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_f9a146bf-0a8b-47cd-8cc5-b9d05e2f700c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnderlyingAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_0764ed7b-5609-41c6-a1d8-edf7c5244e11" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_f9a146bf-0a8b-47cd-8cc5-b9d05e2f700c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_942b2103-a529-4ce2-9655-19464e3d1640" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_f9a146bf-0a8b-47cd-8cc5-b9d05e2f700c" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_942b2103-a529-4ce2-9655-19464e3d1640" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_5d07a25e-4b72-4bf4-9b4d-acc44b0a319c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_f9a146bf-0a8b-47cd-8cc5-b9d05e2f700c" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_5d07a25e-4b72-4bf4-9b4d-acc44b0a319c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeMember_f80c005b-e913-4503-8da9-97312dcc0782" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_f9a146bf-0a8b-47cd-8cc5-b9d05e2f700c" xlink:to="loc_us-gaap_DerivativeMember_f80c005b-e913-4503-8da9-97312dcc0782" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_757927e6-090e-49bd-9d4b-4b242c96aeb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_f9a146bf-0a8b-47cd-8cc5-b9d05e2f700c" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_757927e6-090e-49bd-9d4b-4b242c96aeb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_aa7a129f-00fb-47bf-98ce-c4c6da3b05f2" xlink:href="agnc-20220930.xsd#agnc_ReverseRepurchaseAgreementsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_f9a146bf-0a8b-47cd-8cc5-b9d05e2f700c" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_aa7a129f-00fb-47bf-98ce-c4c6da3b05f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_8008ad04-4632-4183-81a2-854198c35e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_0e96b35d-b357-4cf8-9611-343c72db87be" xlink:to="loc_us-gaap_FinancialInstrumentAxis_8008ad04-4632-4183-81a2-854198c35e5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0ca6f98f-2a79-4ec8-ad12-fd9fda397ed3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_8008ad04-4632-4183-81a2-854198c35e5f" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0ca6f98f-2a79-4ec8-ad12-fd9fda397ed3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AssetsPledgedtoUsMember_ceb16ad0-a750-4ef2-9b11-e44a6592666e" xlink:href="agnc-20220930.xsd#agnc_AssetsPledgedtoUsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0ca6f98f-2a79-4ec8-ad12-fd9fda397ed3" xlink:to="loc_agnc_AssetsPledgedtoUsMember_ceb16ad0-a750-4ef2-9b11-e44a6592666e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_ce7292c5-442f-4adf-b22b-c4d4b8ccedef" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_0e96b35d-b357-4cf8-9611-343c72db87be" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_ce7292c5-442f-4adf-b22b-c4d4b8ccedef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedFinancialInstrumentsSecurities_a83d86d0-0759-4c24-b6d3-1842d2bac80f" xlink:href="agnc-20220930.xsd#agnc_PledgedFinancialInstrumentsSecurities"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_ce7292c5-442f-4adf-b22b-c4d4b8ccedef" xlink:to="loc_agnc_PledgedFinancialInstrumentsSecurities_a83d86d0-0759-4c24-b6d3-1842d2bac80f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_ec3a68b5-446d-47f8-91b6-5beccdca2791" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankStock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_ce7292c5-442f-4adf-b22b-c4d4b8ccedef" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_ec3a68b5-446d-47f8-91b6-5beccdca2791" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_74ec0d2a-a6a2-43f9-b623-08576b2f4a16" xlink:href="agnc-20220930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_ce7292c5-442f-4adf-b22b-c4d4b8ccedef" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_74ec0d2a-a6a2-43f9-b623-08576b2f4a16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_0a1f8690-49ad-409c-80b5-072e5f7636ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_ce7292c5-442f-4adf-b22b-c4d4b8ccedef" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_0a1f8690-49ad-409c-80b5-072e5f7636ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RestrictedCashandSecuritiesPledged_592ff3fd-f1b4-4e6c-9e50-e768d4db8f73" xlink:href="agnc-20220930.xsd#agnc_RestrictedCashandSecuritiesPledged"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_ce7292c5-442f-4adf-b22b-c4d4b8ccedef" xlink:to="loc_agnc_RestrictedCashandSecuritiesPledged_592ff3fd-f1b4-4e6c-9e50-e768d4db8f73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#PledgedAssetsOffsettingAssetsandLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsAbstract_0678e413-4c9c-48ca-ade9-4cd5af59b1ab" xlink:href="agnc-20220930.xsd#agnc_PledgedAssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_b01eca2e-bf66-4099-b8b3-1b03fb2d6ac9" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_0678e413-4c9c-48ca-ade9-4cd5af59b1ab" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_b01eca2e-bf66-4099-b8b3-1b03fb2d6ac9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_a280bfd3-90a3-40ee-ac53-122fedecb0fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_b01eca2e-bf66-4099-b8b3-1b03fb2d6ac9" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_a280bfd3-90a3-40ee-ac53-122fedecb0fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_a2fd6c25-8437-4c3b-9c4e-69681255a761" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_a280bfd3-90a3-40ee-ac53-122fedecb0fb" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_a2fd6c25-8437-4c3b-9c4e-69681255a761" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_39d7aa60-4e44-45d6-b7d4-64bf83109f9d" xlink:href="agnc-20220930.xsd#agnc_ReverseRepurchaseAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_a2fd6c25-8437-4c3b-9c4e-69681255a761" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_39d7aa60-4e44-45d6-b7d4-64bf83109f9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_80a9cdcb-4521-479e-a704-42c43d03bb01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_a2fd6c25-8437-4c3b-9c4e-69681255a761" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_80a9cdcb-4521-479e-a704-42c43d03bb01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_8572d65d-0881-4a1f-bfab-3db4ffa253b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_b01eca2e-bf66-4099-b8b3-1b03fb2d6ac9" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_8572d65d-0881-4a1f-bfab-3db4ffa253b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_263d9629-471d-4893-8af7-6743dd1319cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_8572d65d-0881-4a1f-bfab-3db4ffa253b4" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_263d9629-471d-4893-8af7-6743dd1319cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsMember_e39e7d57-7c19-4fd1-b18e-51faeb570c83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_263d9629-471d-4893-8af7-6743dd1319cb" xlink:to="loc_us-gaap_AssetsMember_e39e7d57-7c19-4fd1-b18e-51faeb570c83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilityMember_0439286f-58d0-4501-acc0-541e8b9a2390" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_263d9629-471d-4893-8af7-6743dd1319cb" xlink:to="loc_us-gaap_LiabilityMember_0439286f-58d0-4501-acc0-541e8b9a2390" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_77bd9035-56c3-4c83-9808-66b0e8568943" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_b01eca2e-bf66-4099-b8b3-1b03fb2d6ac9" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_77bd9035-56c3-4c83-9808-66b0e8568943" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_2db99b31-dcf2-453b-aac8-2cd047ea0532" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_77bd9035-56c3-4c83-9808-66b0e8568943" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_2db99b31-dcf2-453b-aac8-2cd047ea0532" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_91f3d3ed-bd23-4885-acfe-32f86f09b2fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_2db99b31-dcf2-453b-aac8-2cd047ea0532" xlink:to="loc_us-gaap_InterestRateSwapMember_91f3d3ed-bd23-4885-acfe-32f86f09b2fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_acc75199-137a-489e-859e-c159d3e82724" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_2db99b31-dcf2-453b-aac8-2cd047ea0532" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_acc75199-137a-489e-859e-c159d3e82724" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SwaptionMember_a8f1fcfb-4943-4cd4-8e68-7093b479f69d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SwaptionMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_2db99b31-dcf2-453b-aac8-2cd047ea0532" xlink:to="loc_us-gaap_SwaptionMember_a8f1fcfb-4943-4cd4-8e68-7093b479f69d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_f0986d85-a44e-4921-9132-26732d5f9ff9" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_2db99b31-dcf2-453b-aac8-2cd047ea0532" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_f0986d85-a44e-4921-9132-26732d5f9ff9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_6181ebb6-ec72-47f1-bd92-d916c7b94350" xlink:href="agnc-20220930.xsd#agnc_ReverseRepurchaseAgreementsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_2db99b31-dcf2-453b-aac8-2cd047ea0532" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_6181ebb6-ec72-47f1-bd92-d916c7b94350" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:href="agnc-20220930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_b01eca2e-bf66-4099-b8b3-1b03fb2d6ac9" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_82b2db5b-7ffe-4038-9709-d15c97d7ea4b" xlink:href="agnc-20220930.xsd#agnc_GrossAmountOfRecognizedAssetsLiabilities"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:to="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_82b2db5b-7ffe-4038-9709-d15c97d7ea4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_07d10027-4ce3-4b3e-80e1-8499cf4043f3" xlink:href="agnc-20220930.xsd#agnc_GrossAmountOffsetintheConsolidatedBalanceSheets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:to="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_07d10027-4ce3-4b3e-80e1-8499cf4043f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_45c18996-9b1f-4a30-9e89-5ac448dd233d" xlink:href="agnc-20220930.xsd#agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:to="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_45c18996-9b1f-4a30-9e89-5ac448dd233d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_af7e1d74-6be4-4bc6-a64b-8868a49161c5" xlink:href="agnc-20220930.xsd#agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:to="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_af7e1d74-6be4-4bc6-a64b-8868a49161c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_b674e180-1c4d-49ac-8125-c0d65042ce21" xlink:href="agnc-20220930.xsd#agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:to="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_b674e180-1c4d-49ac-8125-c0d65042ce21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_46681bc5-70fa-4bbc-9d70-dbad6b38669a" xlink:href="agnc-20220930.xsd#agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_b155f35d-2cc2-406c-abac-8489742de558" xlink:to="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_46681bc5-70fa-4bbc-9d70-dbad6b38669a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#FairValueMeasurementsDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_1651bda8-1666-4e0d-866d-a714490d82d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1651bda8-1666-4e0d-866d-a714490d82d9" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_db331ae2-fc06-43c8-91c0-ef5fc2500f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_db331ae2-fc06-43c8-91c0-ef5fc2500f6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_992fa618-9c87-4b8a-b90b-bf6a444bceb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_db331ae2-fc06-43c8-91c0-ef5fc2500f6f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_992fa618-9c87-4b8a-b90b-bf6a444bceb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_ee2a0071-16e4-4189-9f91-e3033d8df821" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_992fa618-9c87-4b8a-b90b-bf6a444bceb4" xlink:to="loc_us-gaap_FutureMember_ee2a0071-16e4-4189-9f91-e3033d8df821" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_de640378-8c78-4b35-affe-0005e079dc01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_992fa618-9c87-4b8a-b90b-bf6a444bceb4" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_de640378-8c78-4b35-affe-0005e079dc01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwaptionMember_de0f08a3-566e-41dd-ae77-92aedbbd4162" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwaptionMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_992fa618-9c87-4b8a-b90b-bf6a444bceb4" xlink:to="loc_us-gaap_InterestRateSwaptionMember_de0f08a3-566e-41dd-ae77-92aedbbd4162" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_30743b57-3740-490c-bcee-24b98bbbd622" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_992fa618-9c87-4b8a-b90b-bf6a444bceb4" xlink:to="loc_us-gaap_InterestRateSwapMember_30743b57-3740-490c-bcee-24b98bbbd622" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_db85d034-88f7-46d3-bc69-ffc21db5996a" xlink:href="agnc-20220930.xsd#agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_992fa618-9c87-4b8a-b90b-bf6a444bceb4" xlink:to="loc_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_db85d034-88f7-46d3-bc69-ffc21db5996a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_c9d0cb37-37af-4cf2-8638-0ba81d122e2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_db331ae2-fc06-43c8-91c0-ef5fc2500f6f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_c9d0cb37-37af-4cf2-8638-0ba81d122e2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_8bfc9f44-86f6-4a2d-adaf-ce775ee8c2ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_8bfc9f44-86f6-4a2d-adaf-ce775ee8c2ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_6562e27f-633d-4c88-ad9e-a0d8b526fa8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8bfc9f44-86f6-4a2d-adaf-ce775ee8c2ed" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_6562e27f-633d-4c88-ad9e-a0d8b526fa8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_9151cef6-6a9a-42fb-b34f-a6d9eb917eb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_6562e27f-633d-4c88-ad9e-a0d8b526fa8e" xlink:to="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_9151cef6-6a9a-42fb-b34f-a6d9eb917eb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_5d78f692-827e-416a-a9a4-565b607ec216" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_5d78f692-827e-416a-a9a4-565b607ec216" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_0734db77-70dc-4e18-9fef-5f2c52f091c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_5d78f692-827e-416a-a9a4-565b607ec216" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_0734db77-70dc-4e18-9fef-5f2c52f091c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_16106e05-264a-4b80-95eb-2ee5a3a5d7b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_0734db77-70dc-4e18-9fef-5f2c52f091c9" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_16106e05-264a-4b80-95eb-2ee5a3a5d7b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_53196427-691f-4f7e-9bb8-09be202f6134" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_53196427-691f-4f7e-9bb8-09be202f6134" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a835ee2c-0b17-479f-b684-6a36a6ef0fc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_53196427-691f-4f7e-9bb8-09be202f6134" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a835ee2c-0b17-479f-b684-6a36a6ef0fc8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_42fb8ee5-4056-4111-84eb-21e8009b5e19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a835ee2c-0b17-479f-b684-6a36a6ef0fc8" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_42fb8ee5-4056-4111-84eb-21e8009b5e19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_a996da6c-7281-41f8-aa25-065304202486" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a835ee2c-0b17-479f-b684-6a36a6ef0fc8" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_a996da6c-7281-41f8-aa25-065304202486" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_e835c4a0-700a-420c-8a2b-835fba56e4b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_e835c4a0-700a-420c-8a2b-835fba56e4b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_e835c4a0-700a-420c-8a2b-835fba56e4b1" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativesMember_6ae19656-c3c9-4238-966e-d5cb08499869" xlink:href="agnc-20220930.xsd#agnc_OtherDerivativesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:to="loc_agnc_OtherDerivativesMember_6ae19656-c3c9-4238-966e-d5cb08499869" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_f417239e-92f3-4d76-8cb0-2013b5856a35" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:to="loc_us-gaap_InterestRateSwapMember_f417239e-92f3-4d76-8cb0-2013b5856a35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TBAAndForwardSettlingSecuritiesMember_401e3ca7-51f5-4e01-aab8-23dba833b2e8" xlink:href="agnc-20220930.xsd#agnc_TBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:to="loc_agnc_TBAAndForwardSettlingSecuritiesMember_401e3ca7-51f5-4e01-aab8-23dba833b2e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember_73f3f6b7-e1c7-4784-89d4-8819263590bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FutureMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:to="loc_us-gaap_FutureMember_73f3f6b7-e1c7-4784-89d4-8819263590bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember_9a65b197-6219-4074-9ec7-6822c777213e" xlink:href="agnc-20220930.xsd#agnc_SaleOfTBAAndForwardSettlingSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:to="loc_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember_9a65b197-6219-4074-9ec7-6822c777213e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_3587ceb2-292b-4018-9f18-cb5433df7c48" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_8b2fd670-2fd4-4840-99b3-15735d8f1bdc" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_3587ceb2-292b-4018-9f18-cb5433df7c48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_44d5f952-03d0-4bc1-8b51-b3468a343e10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_44d5f952-03d0-4bc1-8b51-b3468a343e10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_b3a0be9b-3229-4562-a97b-30b245a59019" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_44d5f952-03d0-4bc1-8b51-b3468a343e10" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_b3a0be9b-3229-4562-a97b-30b245a59019" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_9a342ce8-a9c4-4ca4-b54d-ef33e28108b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_b3a0be9b-3229-4562-a97b-30b245a59019" xlink:to="loc_us-gaap_InterestRateSwapMember_9a342ce8-a9c4-4ca4-b54d-ef33e28108b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7c3a9633-0928-4d31-8ea3-21479e1af9bf" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_dcca7c78-2d0f-49e3-a6c3-300a684da1f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_dcca7c78-2d0f-49e3-a6c3-300a684da1f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_35ad7a7f-b937-4feb-8750-d20779aeba3b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_35ad7a7f-b937-4feb-8750-d20779aeba3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TransfersBetweenHierarchyLevels_34d6f917-ef4d-43bf-895d-726a6732d9f3" xlink:href="agnc-20220930.xsd#agnc_TransfersBetweenHierarchyLevels"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_agnc_TransfersBetweenHierarchyLevels_34d6f917-ef4d-43bf-895d-726a6732d9f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_343c8c78-9e8f-4f18-96ea-eb561f5573e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_343c8c78-9e8f-4f18-96ea-eb561f5573e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_aaddd8ea-42d3-40a4-8f87-4d28a9958f61" xlink:href="agnc-20220930.xsd#agnc_NonAgencySecuritiesatFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_aaddd8ea-42d3-40a4-8f87-4d28a9958f61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_54e40758-fd83-49d3-8fc7-c5dcb488a01e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_54e40758-fd83-49d3-8fc7-c5dcb488a01e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_9c367ba4-3271-4575-9570-4671ec9bd55b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_9c367ba4-3271-4575-9570-4671ec9bd55b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_1c59233e-af0f-4e5e-a5cf-599e3f33c67d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_1c59233e-af0f-4e5e-a5cf-599e3f33c67d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_3a1f7096-c262-45d6-b262-4075c605dc52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_DerivativeAssets_3a1f7096-c262-45d6-b262-4075c605dc52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_304bf672-31ce-4527-9a25-7f0e2092eb7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_DerivativeLiabilities_304bf672-31ce-4527-9a25-7f0e2092eb7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_4ba6cfea-ea00-451e-8d61-2afe3d929869" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_4ba6cfea-ea00-451e-8d61-2afe3d929869" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_f879f92a-4d4f-44b4-bae2-c0f9fcd7d818" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLongTermDebt"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_OtherLongTermDebt_f879f92a-4d4f-44b4-bae2-c0f9fcd7d818" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_e7147c9a-b077-4722-8a09-0bb7aa0edfc7" xlink:href="agnc-20220930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_e7147c9a-b077-4722-8a09-0bb7aa0edfc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_348e2d1c-6e9b-4a2c-955a-ad34b7a3a8d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_348e2d1c-6e9b-4a2c-955a-ad34b7a3a8d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_615d0ee6-180d-40f1-babd-1017aa4660bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_22cd287c-1e83-4330-a164-c73366b1983c" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_615d0ee6-180d-40f1-babd-1017aa4660bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#NetIncomeLossPerCommonShareDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NetIncomeLossPerCommonShareAbstract_9ef8a6e8-2329-4f8b-bbc0-a02aa51fd032" xlink:href="agnc-20220930.xsd#agnc_NetIncomeLossPerCommonShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_27d0ca3a-d75c-4791-ab87-7b10a14e7663" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_9ef8a6e8-2329-4f8b-bbc0-a02aa51fd032" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_27d0ca3a-d75c-4791-ab87-7b10a14e7663" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_024194ec-667c-4716-9d8d-e53d21066c54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_27d0ca3a-d75c-4791-ab87-7b10a14e7663" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_024194ec-667c-4716-9d8d-e53d21066c54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_bdf33bfb-7f0f-4829-ad6d-690ddfea6096" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_024194ec-667c-4716-9d8d-e53d21066c54" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_bdf33bfb-7f0f-4829-ad6d-690ddfea6096" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_ab4caa78-e92f-4f2d-b971-5203058a5cb0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_bdf33bfb-7f0f-4829-ad6d-690ddfea6096" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_ab4caa78-e92f-4f2d-b971-5203058a5cb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_2b8f7b83-9dce-43b3-b9fb-341945400fdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_27d0ca3a-d75c-4791-ab87-7b10a14e7663" xlink:to="loc_us-gaap_StatementClassOfStockAxis_2b8f7b83-9dce-43b3-b9fb-341945400fdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_e354e2d1-0cd1-4fa2-8100-a54a5c464c08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_2b8f7b83-9dce-43b3-b9fb-341945400fdb" xlink:to="loc_us-gaap_ClassOfStockDomain_e354e2d1-0cd1-4fa2-8100-a54a5c464c08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDilutedLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_27d0ca3a-d75c-4791-ab87-7b10a14e7663" xlink:to="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageNumberofSharesOutstanding_da6e5988-03af-45d1-81d4-b9e0d321510d" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageNumberofSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_agnc_WeightedAverageNumberofSharesOutstanding_da6e5988-03af-45d1-81d4-b9e0d321510d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding_6d87832c-adc7-4177-b46c-2d90c2fce5b2" xlink:href="agnc-20220930.xsd#agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding_6d87832c-adc7-4177-b46c-2d90c2fce5b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_35e6fee1-588b-4798-b926-c911e9f4ec23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_35e6fee1-588b-4798-b926-c911e9f4ec23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_a536099f-1caa-4891-9db1-51d0392855b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_a536099f-1caa-4891-9db1-51d0392855b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_c842590f-c904-4bee-8a66-fefb63edeba1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_c842590f-c904-4bee-8a66-fefb63edeba1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_18ab21ef-aab0-4c5d-9d62-c36f78a3f0cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_18ab21ef-aab0-4c5d-9d62-c36f78a3f0cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_2d88459f-fde6-4b25-afa8-99c34346dc83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_EarningsPerShareBasic_2d88459f-fde6-4b25-afa8-99c34346dc83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_c86b3bce-e7f0-4393-b09f-b829a8779465" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_EarningsPerShareDiluted_c86b3bce-e7f0-4393-b09f-b829a8779465" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_444ef6d0-3a53-4740-86ad-9a3904190f0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_444ef6d0-3a53-4740-86ad-9a3904190f0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_85d5e2a4-dbff-4a1a-80f7-5b06726f7a80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_306e27b9-ca75-4b4c-a29b-0b417d22be7a" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_85d5e2a4-dbff-4a1a-80f7-5b06726f7a80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityPreferredStockDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_75c16822-387f-40b2-be5d-7b2c7c7d924c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_45e729ef-76ac-4d74-a80c-51b90b2761f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_75c16822-387f-40b2-be5d-7b2c7c7d924c" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_45e729ef-76ac-4d74-a80c-51b90b2761f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_00a8f105-e060-419d-9ddc-6a58361570a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_45e729ef-76ac-4d74-a80c-51b90b2761f6" xlink:to="loc_us-gaap_VariableRateAxis_00a8f105-e060-419d-9ddc-6a58361570a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_c885e9d8-4874-4ab6-9887-aa6d8218fe16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_00a8f105-e060-419d-9ddc-6a58361570a6" xlink:to="loc_us-gaap_VariableRateDomain_c885e9d8-4874-4ab6-9887-aa6d8218fe16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis_323156d7-9db9-432e-acb3-6e82545e1687" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredUnitsByNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_45e729ef-76ac-4d74-a80c-51b90b2761f6" xlink:to="loc_us-gaap_PreferredUnitsByNameAxis_323156d7-9db9-432e-acb3-6e82545e1687" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsClassDomain_11a82c6d-c555-44b9-8572-1add872c167e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredUnitsClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis_323156d7-9db9-432e-acb3-6e82545e1687" xlink:to="loc_us-gaap_PreferredUnitsClassDomain_11a82c6d-c555-44b9-8572-1add872c167e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DepositaryShareMember_900225d6-cf6a-4684-bb4a-5a8c9139c4d2" xlink:href="agnc-20220930.xsd#agnc_DepositaryShareMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsClassDomain_11a82c6d-c555-44b9-8572-1add872c167e" xlink:to="loc_agnc_DepositaryShareMember_900225d6-cf6a-4684-bb4a-5a8c9139c4d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_0d1c3146-2af1-4dc5-9a87-eae83684ffbe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_45e729ef-76ac-4d74-a80c-51b90b2761f6" xlink:to="loc_us-gaap_StatementClassOfStockAxis_0d1c3146-2af1-4dc5-9a87-eae83684ffbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_0d1c3146-2af1-4dc5-9a87-eae83684ffbe" xlink:to="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_317af7ab-7664-463d-9ff5-5078b5504850" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_317af7ab-7664-463d-9ff5-5078b5504850" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_a7c62a0e-1e3b-4390-a9fe-c4cb896326d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesBPreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_a7c62a0e-1e3b-4390-a9fe-c4cb896326d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_015a5e45-a862-4e06-a1d3-ba358242b272" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesCPreferredStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_015a5e45-a862-4e06-a1d3-ba358242b272" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_5889e012-2dcd-4402-8638-16725be8128d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesDPreferredStockMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_5889e012-2dcd-4402-8638-16725be8128d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesEPreferredStockMember_fa796980-9ea2-4730-b0d7-e56e669c7ed8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesEPreferredStockMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:to="loc_us-gaap_SeriesEPreferredStockMember_fa796980-9ea2-4730-b0d7-e56e669c7ed8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesFPreferredStockMember_f1625e20-9cc9-48e6-8aba-152776f27812" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesFPreferredStockMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:to="loc_us-gaap_SeriesFPreferredStockMember_f1625e20-9cc9-48e6-8aba-152776f27812" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesGPreferredStockMember_4469a264-7185-4262-a92a-0ec913bbf01c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesGPreferredStockMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_57431f80-1e59-4f9f-85c8-5b0bc9435dc7" xlink:to="loc_us-gaap_SeriesGPreferredStockMember_4469a264-7185-4262-a92a-0ec913bbf01c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_45e729ef-76ac-4d74-a80c-51b90b2761f6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockBValueIssued_f4cfd222-3d79-438a-b22a-522f845a4a94" xlink:href="agnc-20220930.xsd#agnc_PreferredStockBValueIssued"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockBValueIssued_f4cfd222-3d79-438a-b22a-522f845a4a94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue_12e1c2cb-b082-46df-86ac-6721643d70db" xlink:href="agnc-20220930.xsd#agnc_PreferredStockBLiquidationPreferenceValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockBLiquidationPreferenceValue_12e1c2cb-b082-46df-86ac-6721643d70db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockPercentInterestPerShare_2d8be3eb-d72b-40e7-a68d-c49ce1b472e2" xlink:href="agnc-20220930.xsd#agnc_PreferredStockPercentInterestPerShare"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockPercentInterestPerShare_2d8be3eb-d72b-40e7-a68d-c49ce1b472e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_b0f4921c-dd72-435c-8995-277c7862f2fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_b0f4921c-dd72-435c-8995-277c7862f2fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_b8ef2307-c69f-4382-9c8b-c5f16d025fbc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_PreferredStockDividendRatePercentage_b8ef2307-c69f-4382-9c8b-c5f16d025fbc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockEValueIssued_360eacaf-ff76-4222-badb-80dc13b751e6" xlink:href="agnc-20220930.xsd#agnc_PreferredStockEValueIssued"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockEValueIssued_360eacaf-ff76-4222-badb-80dc13b751e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockELiquidationPreferenceValue_25fd911e-4037-4d4d-abfd-fab17cde8b93" xlink:href="agnc-20220930.xsd#agnc_PreferredStockELiquidationPreferenceValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockELiquidationPreferenceValue_25fd911e-4037-4d4d-abfd-fab17cde8b93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_a83b15d0-00a5-45fe-8ee0-84795038f515" xlink:href="agnc-20220930.xsd#agnc_PreferredStockDividendPaymentRateVariableRateSpread"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_a83b15d0-00a5-45fe-8ee0-84795038f515" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_024a0478-bdf2-416c-bed4-93a74238b7a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockLiquidationPreference"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_PreferredStockLiquidationPreference_024a0478-bdf2-416c-bed4-93a74238b7a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_f0f94107-2cee-4587-8475-cb843690a26e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_PreferredStockSharesIssued_f0f94107-2cee-4587-8475-cb843690a26e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockFValueIssued_c7da0d8a-d347-4c0d-8adc-6e40613b431b" xlink:href="agnc-20220930.xsd#agnc_PreferredStockFValueIssued"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockFValueIssued_c7da0d8a-d347-4c0d-8adc-6e40613b431b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDValueIssued_d32d78d8-fa72-47b4-b7cf-83f1401d5964" xlink:href="agnc-20220930.xsd#agnc_PreferredStockDValueIssued"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockDValueIssued_d32d78d8-fa72-47b4-b7cf-83f1401d5964" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDLiquidationPreferenceValue_f5d05bd7-48a4-476b-9e7c-8e7f68ce46ac" xlink:href="agnc-20220930.xsd#agnc_PreferredStockDLiquidationPreferenceValue"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockDLiquidationPreferenceValue_f5d05bd7-48a4-476b-9e7c-8e7f68ce46ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockAuthorizedButNotIssued_768d2432-b611-4fe9-90e3-908e0e173045" xlink:href="agnc-20220930.xsd#agnc_PreferredStockAuthorizedButNotIssued"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockAuthorizedButNotIssued_768d2432-b611-4fe9-90e3-908e0e173045" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_4e26530e-034f-4f70-9293-d1f85abc085f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_4e26530e-034f-4f70-9293-d1f85abc085f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_24028dfb-d349-4f0a-b39f-c3f99d4943c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_24028dfb-d349-4f0a-b39f-c3f99d4943c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockCValueIssued_7b09bc7c-b2fb-4a33-89f2-8df42b314046" xlink:href="agnc-20220930.xsd#agnc_PreferredStockCValueIssued"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockCValueIssued_7b09bc7c-b2fb-4a33-89f2-8df42b314046" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue_86768e27-133a-4017-9683-5e2ee73d8d14" xlink:href="agnc-20220930.xsd#agnc_PreferredStockCLiquidationPreferenceValue"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockCLiquidationPreferenceValue_86768e27-133a-4017-9683-5e2ee73d8d14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_07356506-746d-453b-be5a-6dcea163ddc2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_PreferredStockValue_07356506-746d-453b-be5a-6dcea163ddc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_1f6fbcde-18db-4796-b456-28d4696cb3e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_1f6fbcde-18db-4796-b456-28d4696cb3e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockGValueIssued_62cf4e7d-5f1c-4f00-a5f1-8d1a1aa48028" xlink:href="agnc-20220930.xsd#agnc_PreferredStockGValueIssued"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7624aa12-1cb1-4ba8-8b05-f02657271d99" xlink:to="loc_agnc_PreferredStockGValueIssued_62cf4e7d-5f1c-4f00-a5f1-8d1a1aa48028" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_550f0ef6-c23c-4896-94fc-db002deb055d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_75c16822-387f-40b2-be5d-7b2c7c7d924c" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_550f0ef6-c23c-4896-94fc-db002deb055d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityCommonStockRepurchaseProgramDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_2ed93c51-fa02-4e7b-a600-78a5eaeef395" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_15db551c-3b86-4b87-a4aa-78661315631d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_2ed93c51-fa02-4e7b-a600-78a5eaeef395" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_15db551c-3b86-4b87-a4aa-78661315631d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_30557966-6267-4cd1-9a0a-d7321858c843" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_15db551c-3b86-4b87-a4aa-78661315631d" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_30557966-6267-4cd1-9a0a-d7321858c843" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_ef5ba179-f484-4207-9e81-9779a7873682" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_30557966-6267-4cd1-9a0a-d7321858c843" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_ef5ba179-f484-4207-9e81-9779a7873682" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_d2bc791f-9151-411a-bd03-544162db3a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_30557966-6267-4cd1-9a0a-d7321858c843" xlink:to="loc_us-gaap_PlanNameDomain_d2bc791f-9151-411a-bd03-544162db3a3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_e954afd6-2537-4ea0-a381-2d79b82fe871" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_15db551c-3b86-4b87-a4aa-78661315631d" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_e954afd6-2537-4ea0-a381-2d79b82fe871" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_5aeecf2d-0d77-426b-b183-3c8734c0feea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_e954afd6-2537-4ea0-a381-2d79b82fe871" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_5aeecf2d-0d77-426b-b183-3c8734c0feea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_31a1aba6-47b3-4161-a6db-248034411057" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_5aeecf2d-0d77-426b-b183-3c8734c0feea" xlink:to="loc_us-gaap_SubsequentEventMember_31a1aba6-47b3-4161-a6db-248034411057" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2262091b-d618-4f0e-9157-f327581de0ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_15db551c-3b86-4b87-a4aa-78661315631d" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2262091b-d618-4f0e-9157-f327581de0ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_fbcd5692-2af3-4fcb-95a0-0ff576e706f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2262091b-d618-4f0e-9157-f327581de0ad" xlink:to="loc_us-gaap_EquityComponentDomain_fbcd5692-2af3-4fcb-95a0-0ff576e706f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_004f2516-a581-478d-89f5-cd81f91e42eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_fbcd5692-2af3-4fcb-95a0-0ff576e706f1" xlink:to="loc_us-gaap_CommonStockMember_004f2516-a581-478d-89f5-cd81f91e42eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_15db551c-3b86-4b87-a4aa-78661315631d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_288052e2-a796-4727-8390-5137c38ce99b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_288052e2-a796-4727-8390-5137c38ce99b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_6e902f04-d3ee-4c38-b6de-94a76ad96584" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_6e902f04-d3ee-4c38-b6de-94a76ad96584" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_5c0e52ce-c2c3-4bdb-8018-88c7a5d6c155" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_5c0e52ce-c2c3-4bdb-8018-88c7a5d6c155" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_46e7ac33-76f2-426f-a483-c57810ab31aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_46e7ac33-76f2-426f-a483-c57810ab31aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_dc29d957-a9ad-47f6-86ad-5740a344cb5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_dc29d957-a9ad-47f6-86ad-5740a344cb5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_fd31a290-694c-47b4-9e05-696f88ef79c7" xlink:href="agnc-20220930.xsd#agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_fd31a290-694c-47b4-9e05-696f88ef79c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_a2fe0ec4-32e2-4f71-a915-3a644b8a6324" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_a2fe0ec4-32e2-4f71-a915-3a644b8a6324" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodTradeDateShares_a5b33361-e792-4360-85d3-d0b744522624" xlink:href="agnc-20220930.xsd#agnc_StockRepurchasedDuringPeriodTradeDateShares"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_agnc_StockRepurchasedDuringPeriodTradeDateShares_a5b33361-e792-4360-85d3-d0b744522624" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodTradeDateValue_c681cf37-a4be-4f22-b030-1af03334b6bb" xlink:href="agnc-20220930.xsd#agnc_StockRepurchasedDuringPeriodTradeDateValue"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_agnc_StockRepurchasedDuringPeriodTradeDateValue_c681cf37-a4be-4f22-b030-1af03334b6bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue_80bbfaf3-8676-43b8-8e78-b3df29349892" xlink:href="agnc-20220930.xsd#agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue_80bbfaf3-8676-43b8-8e78-b3df29349892" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodSettledAfterShares_84147162-1a6c-4858-b016-f329d49d3d16" xlink:href="agnc-20220930.xsd#agnc_StockRepurchasedDuringPeriodSettledAfterShares"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c9f2f765-7e32-4cd8-846f-bceec7d45496" xlink:to="loc_agnc_StockRepurchasedDuringPeriodSettledAfterShares_84147162-1a6c-4858-b016-f329d49d3d16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_cc76c3e1-8668-40f5-8d96-5f238f2383d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2be8a151-1c14-4cd9-9989-e093686a7c91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_cc76c3e1-8668-40f5-8d96-5f238f2383d1" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2be8a151-1c14-4cd9-9989-e093686a7c91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_3d28a187-2b74-4325-ac99-8ff580a24dc4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2be8a151-1c14-4cd9-9989-e093686a7c91" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_3d28a187-2b74-4325-ac99-8ff580a24dc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_bb6ddfc5-26ca-4f95-a343-90acf609180a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_3d28a187-2b74-4325-ac99-8ff580a24dc4" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_bb6ddfc5-26ca-4f95-a343-90acf609180a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_f54e221e-2782-4991-b9fa-84e3d1b4276d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_bb6ddfc5-26ca-4f95-a343-90acf609180a" xlink:to="loc_us-gaap_InterestRateSwapMember_f54e221e-2782-4991-b9fa-84e3d1b4276d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_d3706eb6-2ea2-49a9-9606-1b35f43b6859" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2be8a151-1c14-4cd9-9989-e093686a7c91" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_d3706eb6-2ea2-49a9-9606-1b35f43b6859" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_597a3346-0059-4876-abc9-b9539799d591" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_d3706eb6-2ea2-49a9-9606-1b35f43b6859" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_597a3346-0059-4876-abc9-b9539799d591" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_34dde5b1-506d-4611-8ba4-a06043cf2bfe" xlink:href="agnc-20220930.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_597a3346-0059-4876-abc9-b9539799d591" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_34dde5b1-506d-4611-8ba4-a06043cf2bfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_6ea8c693-d1e5-4053-9e4e-23c58ffd7c6e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2be8a151-1c14-4cd9-9989-e093686a7c91" xlink:to="loc_us-gaap_FinancialInstrumentAxis_6ea8c693-d1e5-4053-9e4e-23c58ffd7c6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1e84cd9e-7cc1-4d54-bd8c-fa68db252e0d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_6ea8c693-d1e5-4053-9e4e-23c58ffd7c6e" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1e84cd9e-7cc1-4d54-bd8c-fa68db252e0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AgencySecuritiesMember_aaa79884-0b36-457f-89c6-c273a7b13c63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AgencySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1e84cd9e-7cc1-4d54-bd8c-fa68db252e0d" xlink:to="loc_us-gaap_AgencySecuritiesMember_aaa79884-0b36-457f-89c6-c273a7b13c63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2be8a151-1c14-4cd9-9989-e093686a7c91" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4d51d2d3-4638-4044-9ac9-9382f80a2c7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4d51d2d3-4638-4044-9ac9-9382f80a2c7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_58410b3a-999c-4388-a7fe-274e65a19bb5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:to="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_58410b3a-999c-4388-a7fe-274e65a19bb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_6eef029a-7704-4732-bc6d-6d7b171d81e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_6eef029a-7704-4732-bc6d-6d7b171d81e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_c2482dea-3068-43b4-ae1c-b264b23ec371" xlink:href="agnc-20220930.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:to="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_c2482dea-3068-43b4-ae1c-b264b23ec371" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_25a5ca7d-d4b4-44ec-a05f-6d2d7898f13f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_25a5ca7d-d4b4-44ec-a05f-6d2d7898f13f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_7b42a2c9-0b84-4277-b788-c3f09efacbd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d36a2ffd-d48b-4eeb-8ed3-c51c5c44d709" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_7b42a2c9-0b84-4277-b788-c3f09efacbd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityFollowOnEquityOfferingsDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_b1e770d2-d17e-4e4e-9a27-e3503be965dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_a65c47a1-80b5-4091-9235-b9987893f874" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_b1e770d2-d17e-4e4e-9a27-e3503be965dd" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_a65c47a1-80b5-4091-9235-b9987893f874" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_ee5b0f4f-e241-4d12-b2c7-4c70dbd4fd92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_a65c47a1-80b5-4091-9235-b9987893f874" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_ee5b0f4f-e241-4d12-b2c7-4c70dbd4fd92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7a138f6b-fc8c-4635-a565-e4183a994a99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_ee5b0f4f-e241-4d12-b2c7-4c70dbd4fd92" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7a138f6b-fc8c-4635-a565-e4183a994a99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FollowOnPublicOfferingMember_09327c5b-b814-4b36-a395-1e79cc5dddcc" xlink:href="agnc-20220930.xsd#agnc_FollowOnPublicOfferingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7a138f6b-fc8c-4635-a565-e4183a994a99" xlink:to="loc_agnc_FollowOnPublicOfferingMember_09327c5b-b814-4b36-a395-1e79cc5dddcc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_b1f7d099-c84c-47c5-919e-39c7c4ab7966" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_a65c47a1-80b5-4091-9235-b9987893f874" xlink:to="loc_us-gaap_ClassOfStockLineItems_b1f7d099-c84c-47c5-919e-39c7c4ab7966" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_cf39232b-575d-4787-9137-4e770f2fa521" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_b1f7d099-c84c-47c5-919e-39c7c4ab7966" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_cf39232b-575d-4787-9137-4e770f2fa521" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_7ebd1213-d651-4ed6-8993-e1bd3552e6a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_b1f7d099-c84c-47c5-919e-39c7c4ab7966" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_7ebd1213-d651-4ed6-8993-e1bd3552e6a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_d6449380-f096-4943-a3b5-dbc89f21ba4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_b1f7d099-c84c-47c5-919e-39c7c4ab7966" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_d6449380-f096-4943-a3b5-dbc89f21ba4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAttheMarketOfferingProgramDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityAttheMarketOfferingProgramDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAttheMarketOfferingProgramDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_79894e44-7e2d-4ee6-9d7f-08092583f052" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9e26c806-0712-4305-8ca7-7ea507273481" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_79894e44-7e2d-4ee6-9d7f-08092583f052" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9e26c806-0712-4305-8ca7-7ea507273481" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_18cab4e3-5ba6-40de-a93b-39775ac5c2b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9e26c806-0712-4305-8ca7-7ea507273481" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_18cab4e3-5ba6-40de-a93b-39775ac5c2b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_1e1d43e2-cc13-45d9-bc40-9daf1cb3c574" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_18cab4e3-5ba6-40de-a93b-39775ac5c2b9" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_1e1d43e2-cc13-45d9-bc40-9daf1cb3c574" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CommonStockAtTheMarketSaleAgreementMember_5d413caf-9da1-415d-a699-c8dfcf34ccc1" xlink:href="agnc-20220930.xsd#agnc_CommonStockAtTheMarketSaleAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_1e1d43e2-cc13-45d9-bc40-9daf1cb3c574" xlink:to="loc_agnc_CommonStockAtTheMarketSaleAgreementMember_5d413caf-9da1-415d-a699-c8dfcf34ccc1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_18f85eb1-b46f-4fb7-b06b-c924137a9748" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9e26c806-0712-4305-8ca7-7ea507273481" xlink:to="loc_us-gaap_StatementClassOfStockAxis_18f85eb1-b46f-4fb7-b06b-c924137a9748" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_a1b228b9-362a-4bd0-a58d-75123a6d53d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_18f85eb1-b46f-4fb7-b06b-c924137a9748" xlink:to="loc_us-gaap_ClassOfStockDomain_a1b228b9-362a-4bd0-a58d-75123a6d53d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_aef1c099-1afb-4e57-890f-cde6c7c647e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_a1b228b9-362a-4bd0-a58d-75123a6d53d7" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_aef1c099-1afb-4e57-890f-cde6c7c647e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_fe54646b-b7c1-4658-b950-e43010d748ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9e26c806-0712-4305-8ca7-7ea507273481" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_fe54646b-b7c1-4658-b950-e43010d748ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_ef44080f-2c18-43e9-9da1-a86bb35bbbc2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_fe54646b-b7c1-4658-b950-e43010d748ef" xlink:to="loc_us-gaap_EquityComponentDomain_ef44080f-2c18-43e9-9da1-a86bb35bbbc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9e26c806-0712-4305-8ca7-7ea507273481" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_a1078339-eaae-4d43-80ff-29800e00f57f" xlink:href="agnc-20220930.xsd#agnc_CommonstockValueofSharesApprovedforFutureIssuance"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:to="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_a1078339-eaae-4d43-80ff-29800e00f57f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_98d893f2-9fc0-4f13-9b80-b70a88bd5bc1" xlink:href="agnc-20220930.xsd#agnc_CommonstockValueofSharesRemainingforFutureIssuance"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:to="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_98d893f2-9fc0-4f13-9b80-b70a88bd5bc1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_16c885f7-e0f3-4ed1-a3e6-4ceb5d71a77c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_16c885f7-e0f3-4ed1-a3e6-4ceb5d71a77c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_a3345ec2-0083-4768-a661-2602a905e1b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_a3345ec2-0083-4768-a661-2602a905e1b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_03999f76-31c9-4be2-8852-dd1eb241a197" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_03999f76-31c9-4be2-8852-dd1eb241a197" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockIssuedDuringPeriodPricePerShare_29b9ed91-bfea-460f-a6b7-a74c086305f1" xlink:href="agnc-20220930.xsd#agnc_StockIssuedDuringPeriodPricePerShare"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7a3434c9-5470-4e29-a964-91990d87b8d2" xlink:to="loc_agnc_StockIssuedDuringPeriodPricePerShare_29b9ed91-bfea-460f-a6b7-a74c086305f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentandDirectStockPurchasePlanDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityDividendReinvestmentandDirectStockPurchasePlanDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentandDirectStockPurchasePlanDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_9cb48361-4be6-45d8-ac90-bd62a6225479" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a1a9cd2c-ce4c-4508-bcb7-04df10830eaa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_9cb48361-4be6-45d8-ac90-bd62a6225479" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a1a9cd2c-ce4c-4508-bcb7-04df10830eaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5c2ce8e0-be77-4ef9-b9fe-de22f21f99dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a1a9cd2c-ce4c-4508-bcb7-04df10830eaa" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5c2ce8e0-be77-4ef9-b9fe-de22f21f99dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_320e014d-13a9-41fc-9d09-6c800ecf1a67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5c2ce8e0-be77-4ef9-b9fe-de22f21f99dd" xlink:to="loc_us-gaap_ClassOfStockDomain_320e014d-13a9-41fc-9d09-6c800ecf1a67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredClassBMember_35509f60-d54c-4ed2-bdb1-c7e9ea853d77" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredClassBMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_320e014d-13a9-41fc-9d09-6c800ecf1a67" xlink:to="loc_us-gaap_PreferredClassBMember_35509f60-d54c-4ed2-bdb1-c7e9ea853d77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_d4a977ef-ef44-4297-9c47-72d2c05e1792" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesCPreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_320e014d-13a9-41fc-9d09-6c800ecf1a67" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_d4a977ef-ef44-4297-9c47-72d2c05e1792" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_45dfbf26-5c45-470a-8994-372f8e14699e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesDPreferredStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_320e014d-13a9-41fc-9d09-6c800ecf1a67" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_45dfbf26-5c45-470a-8994-372f8e14699e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesEPreferredStockMember_599bc26d-b86b-4973-9e98-7688236bd440" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesEPreferredStockMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_320e014d-13a9-41fc-9d09-6c800ecf1a67" xlink:to="loc_us-gaap_SeriesEPreferredStockMember_599bc26d-b86b-4973-9e98-7688236bd440" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_c5439575-bac5-4055-8691-59bccd843c5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a1a9cd2c-ce4c-4508-bcb7-04df10830eaa" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_c5439575-bac5-4055-8691-59bccd843c5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_1e3e8ff7-f997-481c-8687-eb5fbc2f873b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_c5439575-bac5-4055-8691-59bccd843c5a" xlink:to="loc_us-gaap_EquityComponentDomain_1e3e8ff7-f997-481c-8687-eb5fbc2f873b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_526dbe1b-77be-4054-8d59-2e86f02ad77e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a1a9cd2c-ce4c-4508-bcb7-04df10830eaa" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_526dbe1b-77be-4054-8d59-2e86f02ad77e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPreferredStock_da9f4da7-ef60-4a4a-acc7-cced1886816a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPreferredStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_526dbe1b-77be-4054-8d59-2e86f02ad77e" xlink:to="loc_us-gaap_DividendsPreferredStock_da9f4da7-ef60-4a4a-acc7-cced1886816a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_966d5228-b2df-42e3-816c-6524d4b85b54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendRatePerDollarAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_526dbe1b-77be-4054-8d59-2e86f02ad77e" xlink:to="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_966d5228-b2df-42e3-816c-6524d4b85b54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStock_36f7fb85-4021-4bcf-9346-ebe82d280adf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsCommonStock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_526dbe1b-77be-4054-8d59-2e86f02ad77e" xlink:to="loc_us-gaap_DividendsCommonStock_36f7fb85-4021-4bcf-9346-ebe82d280adf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_a42e36d7-38da-4b62-a9c3-3337f3b0c453" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_526dbe1b-77be-4054-8d59-2e86f02ad77e" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_a42e36d7-38da-4b62-a9c3-3337f3b0c453" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityLongtermIncentivePlanDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityLongtermIncentivePlanDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityLongtermIncentivePlanDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_bd55c0ee-1052-49be-a73e-21a2248e8752" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c6c9b3f-0ad9-4368-9d73-0ad6c85e490e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_bd55c0ee-1052-49be-a73e-21a2248e8752" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c6c9b3f-0ad9-4368-9d73-0ad6c85e490e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_86da4df6-3b9e-4227-8ca5-c2ee37748875" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_TitleOfIndividualAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c6c9b3f-0ad9-4368-9d73-0ad6c85e490e" xlink:to="loc_srt_TitleOfIndividualAxis_86da4df6-3b9e-4227-8ca5-c2ee37748875" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_ecc210e9-b59a-49ba-9243-e0be52273855" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualAxis_86da4df6-3b9e-4227-8ca5-c2ee37748875" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_ecc210e9-b59a-49ba-9243-e0be52273855" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_40ed683c-cd4b-42a1-8296-c54e48224333" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c6c9b3f-0ad9-4368-9d73-0ad6c85e490e" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_40ed683c-cd4b-42a1-8296-c54e48224333" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_cd8a4fa1-95d9-41e9-8ef3-7a29a8977f2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_40ed683c-cd4b-42a1-8296-c54e48224333" xlink:to="loc_us-gaap_RelatedPartyDomain_cd8a4fa1-95d9-41e9-8ef3-7a29a8977f2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_01556921-249f-44a1-8516-2cf02b44f549" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c6c9b3f-0ad9-4368-9d73-0ad6c85e490e" xlink:to="loc_us-gaap_AwardTypeAxis_01556921-249f-44a1-8516-2cf02b44f549" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_52d8a6d9-7599-46b0-a638-87898ba7284d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_01556921-249f-44a1-8516-2cf02b44f549" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_52d8a6d9-7599-46b0-a638-87898ba7284d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6308d0af-1631-48b1-85f0-9034773ed486" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c6c9b3f-0ad9-4368-9d73-0ad6c85e490e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6308d0af-1631-48b1-85f0-9034773ed486" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityScheduleofDividendsDeclaredDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#StockholdersEquityScheduleofDividendsDeclaredDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityScheduleofDividendsDeclaredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleofDividendsDeclaredAbstract_18b619f9-e4a1-4135-9b56-cfa5b7bc563e" xlink:href="agnc-20220930.xsd#agnc_ScheduleofDividendsDeclaredAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_759ccca5-b26f-42b5-9935-26d0297d4d1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ScheduleofDividendsDeclaredAbstract_18b619f9-e4a1-4135-9b56-cfa5b7bc563e" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_759ccca5-b26f-42b5-9935-26d0297d4d1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_2c5692a3-f401-4b10-89d7-5dafc0c12d8c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_759ccca5-b26f-42b5-9935-26d0297d4d1f" xlink:to="loc_us-gaap_StatementClassOfStockAxis_2c5692a3-f401-4b10-89d7-5dafc0c12d8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_2c5692a3-f401-4b10-89d7-5dafc0c12d8c" xlink:to="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredClassBMember_0c505367-f240-400c-9907-cbf46f63f340" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredClassBMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:to="loc_us-gaap_PreferredClassBMember_0c505367-f240-400c-9907-cbf46f63f340" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_0a47164f-9330-4ba8-9e74-bd196b0ad516" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesCPreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_0a47164f-9330-4ba8-9e74-bd196b0ad516" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_c4c95f44-5ca0-4aff-ae04-51d852a16dfc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesDPreferredStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_c4c95f44-5ca0-4aff-ae04-51d852a16dfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesEPreferredStockMember_4856bf2d-ed46-4ed2-b35f-4201ec85b0f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesEPreferredStockMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:to="loc_us-gaap_SeriesEPreferredStockMember_4856bf2d-ed46-4ed2-b35f-4201ec85b0f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesFPreferredStockMember_17ba473a-5037-4cfa-91e9-f6cddcbcbca4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesFPreferredStockMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:to="loc_us-gaap_SeriesFPreferredStockMember_17ba473a-5037-4cfa-91e9-f6cddcbcbca4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_7993a47e-ab6b-482a-9b20-fa5588dc6524" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesBPreferredStockMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_7993a47e-ab6b-482a-9b20-fa5588dc6524" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_14e377cc-b0b2-4dd1-b2b9-00b822fdb8cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c23de5e8-59f8-4e28-a10a-cfa0a678adbb" xlink:to="loc_us-gaap_CommonStockMember_14e377cc-b0b2-4dd1-b2b9-00b822fdb8cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_759ccca5-b26f-42b5-9935-26d0297d4d1f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPreferredStock_7ea76368-4e45-4f97-8eb3-6e4d4cc0c055" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPreferredStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_us-gaap_DividendsPreferredStock_7ea76368-4e45-4f97-8eb3-6e4d4cc0c055" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsPerShareDeclared_ab6bf1b3-b159-4d56-bb67-2ad124a5fb36" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendsPerShareDeclared"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_us-gaap_PreferredStockDividendsPerShareDeclared_ab6bf1b3-b159-4d56-bb67-2ad124a5fb36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStock_84614247-765e-4e62-81df-96764ebd4e2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsCommonStock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_us-gaap_DividendsCommonStock_84614247-765e-4e62-81df-96764ebd4e2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_5632a045-c22f-4b8c-bd93-41dd3680ff39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_5632a045-c22f-4b8c-bd93-41dd3680ff39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsPerShareCashPaid_8b46a423-e9c9-40ac-81fe-23042e1aae2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendsPerShareCashPaid"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_us-gaap_PreferredStockDividendsPerShareCashPaid_8b46a423-e9c9-40ac-81fe-23042e1aae2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_6c8c5610-f687-4772-9bbe-467c4a345818" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_6c8c5610-f687-4772-9bbe-467c4a345818" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OrdinaryDividendsPerShare_c7d6c4c8-1d32-48d7-ba60-312e5b8eff15" xlink:href="agnc-20220930.xsd#agnc_OrdinaryDividendsPerShare"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_agnc_OrdinaryDividendsPerShare_c7d6c4c8-1d32-48d7-ba60-312e5b8eff15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LongTermCapitalGainDividendPerShare_bb593d7a-0a1c-45e5-9f05-e656767b9d36" xlink:href="agnc-20220930.xsd#agnc_LongTermCapitalGainDividendPerShare"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_agnc_LongTermCapitalGainDividendPerShare_bb593d7a-0a1c-45e5-9f05-e656767b9d36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonDividendDistributionsPerShare_2a086455-cb8f-49af-a29e-72d12cb89b17" xlink:href="agnc-20220930.xsd#agnc_NonDividendDistributionsPerShare"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_agnc_NonDividendDistributionsPerShare_2a086455-cb8f-49af-a29e-72d12cb89b17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Section199ADividendsPerShare_dd0e3612-4fb5-477b-aa49-363fe16e00bd" xlink:href="agnc-20220930.xsd#agnc_Section199ADividendsPerShare"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5c2acc0c-c4bf-4dbb-873f-47eaf5144c8b" xlink:to="loc_agnc_Section199ADividendsPerShare_dd0e3612-4fb5-477b-aa49-363fe16e00bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="simple" xlink:href="agnc-20220930.xsd#SubsequentEventDetails"/>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_75e94f49-19bc-40e1-b888-95377b884154" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_d7297cc4-51d3-4c2a-b5f0-2e5890d415af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_75e94f49-19bc-40e1-b888-95377b884154" xlink:to="loc_us-gaap_SubsequentEventTable_d7297cc4-51d3-4c2a-b5f0-2e5890d415af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis_6f230418-5c71-4b9d-a080-b498ec694c7c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredUnitsByNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_d7297cc4-51d3-4c2a-b5f0-2e5890d415af" xlink:to="loc_us-gaap_PreferredUnitsByNameAxis_6f230418-5c71-4b9d-a080-b498ec694c7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsClassDomain_84dd4044-2bbe-4bcb-b1bf-e2dae12ffb8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredUnitsClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis_6f230418-5c71-4b9d-a080-b498ec694c7c" xlink:to="loc_us-gaap_PreferredUnitsClassDomain_84dd4044-2bbe-4bcb-b1bf-e2dae12ffb8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DepositaryShareMember_09fa8315-b442-4fdd-af3d-782c909ec2de" xlink:href="agnc-20220930.xsd#agnc_DepositaryShareMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsClassDomain_84dd4044-2bbe-4bcb-b1bf-e2dae12ffb8e" xlink:to="loc_agnc_DepositaryShareMember_09fa8315-b442-4fdd-af3d-782c909ec2de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_8fd57e2f-cf36-496e-a3d6-467363bfe23d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_d7297cc4-51d3-4c2a-b5f0-2e5890d415af" xlink:to="loc_us-gaap_StatementClassOfStockAxis_8fd57e2f-cf36-496e-a3d6-467363bfe23d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_aab1f3bc-019f-4584-9321-cc6f6bb6c5d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8fd57e2f-cf36-496e-a3d6-467363bfe23d" xlink:to="loc_us-gaap_ClassOfStockDomain_aab1f3bc-019f-4584-9321-cc6f6bb6c5d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesFPreferredStockMember_5dc16515-cea5-4a40-8ebf-59d878beed8a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesFPreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_aab1f3bc-019f-4584-9321-cc6f6bb6c5d5" xlink:to="loc_us-gaap_SeriesFPreferredStockMember_5dc16515-cea5-4a40-8ebf-59d878beed8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_fe9c59db-2208-4b50-b76b-8df7558d5210" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_d7297cc4-51d3-4c2a-b5f0-2e5890d415af" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_fe9c59db-2208-4b50-b76b-8df7558d5210" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_77224ecc-137d-4ab4-81ef-5733e6ad270f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_fe9c59db-2208-4b50-b76b-8df7558d5210" xlink:to="loc_us-gaap_EquityComponentDomain_77224ecc-137d-4ab4-81ef-5733e6ad270f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_17bfaeb7-9ddf-4b0e-819b-bb91bf30dc9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_77224ecc-137d-4ab4-81ef-5733e6ad270f" xlink:to="loc_us-gaap_CommonStockMember_17bfaeb7-9ddf-4b0e-819b-bb91bf30dc9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_49db9cb8-6736-4eb8-abff-25ad755d964a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_d7297cc4-51d3-4c2a-b5f0-2e5890d415af" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_49db9cb8-6736-4eb8-abff-25ad755d964a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_88c84967-5842-431b-b957-eaaf912d0fd7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_49db9cb8-6736-4eb8-abff-25ad755d964a" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_88c84967-5842-431b-b957-eaaf912d0fd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_8d63908d-e3e3-408b-af35-6a5d3defe98d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_88c84967-5842-431b-b957-eaaf912d0fd7" xlink:to="loc_us-gaap_SubsequentEventMember_8d63908d-e3e3-408b-af35-6a5d3defe98d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_d7297cc4-51d3-4c2a-b5f0-2e5890d415af" xlink:to="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_50b54656-6dd7-48a5-8828-019afdb5059d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_50b54656-6dd7-48a5-8828-019afdb5059d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_4fa12b40-e33c-4064-b7b4-cea38e01efb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_PreferredStockDividendRatePercentage_4fa12b40-e33c-4064-b7b4-cea38e01efb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDValueIssued_f030ff34-76ba-4b31-9d3a-f2539124605f" xlink:href="agnc-20220930.xsd#agnc_PreferredStockDValueIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_agnc_PreferredStockDValueIssued_f030ff34-76ba-4b31-9d3a-f2539124605f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockEValueIssued_8ecd4a2c-6f90-4fdf-a306-c640045299da" xlink:href="agnc-20220930.xsd#agnc_PreferredStockEValueIssued"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_agnc_PreferredStockEValueIssued_8ecd4a2c-6f90-4fdf-a306-c640045299da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_5fa038e9-b91c-4bf3-b90a-73f6dbdc59b6" xlink:href="agnc-20220930.xsd#agnc_PreferredStockDividendPaymentRateVariableRateSpread"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_5fa038e9-b91c-4bf3-b90a-73f6dbdc59b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockELiquidationPreferenceValue_0d2f6302-f354-4e4a-8757-534130dc6b69" xlink:href="agnc-20220930.xsd#agnc_PreferredStockELiquidationPreferenceValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_agnc_PreferredStockELiquidationPreferenceValue_0d2f6302-f354-4e4a-8757-534130dc6b69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_7182d312-edb9-43ee-9e18-75ccd9d9eb67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_PreferredStockSharesIssued_7182d312-edb9-43ee-9e18-75ccd9d9eb67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPreferredStockCash_ff44f104-5d38-4c99-bc97-f9b75ca258bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPreferredStockCash"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_DividendsPreferredStockCash_ff44f104-5d38-4c99-bc97-f9b75ca258bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendPreferenceOrRestrictions_c4bf3758-dfbf-4f78-8be3-49d80ed29306" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendPreferenceOrRestrictions"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_PreferredStockDividendPreferenceOrRestrictions_c4bf3758-dfbf-4f78-8be3-49d80ed29306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_1e708ed6-739e-4836-8d1d-634c605a7ff9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_1e708ed6-739e-4836-8d1d-634c605a7ff9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_daf56948-73e3-41d5-a159-56bf6c99b6d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_daf56948-73e3-41d5-a159-56bf6c99b6d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_05b4cbed-acfc-43cf-a4b6-7f575a8a0def" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_05b4cbed-acfc-43cf-a4b6-7f575a8a0def" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnContractTermination_4406b80e-84a7-4915-8c1d-5f45636e0ccf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnContractTermination"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_GainLossOnContractTermination_4406b80e-84a7-4915-8c1d-5f45636e0ccf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_9146a09d-a16a-4bb4-9035-e5a6445b4738" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_9146a09d-a16a-4bb4-9035-e5a6445b4738" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_6760c754-2a88-4a0d-a089-48ea142f1abb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_6760c754-2a88-4a0d-a089-48ea142f1abb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_845ae7cb-1e39-48ee-88a7-1c9038b72e08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockLiquidationPreference"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_PreferredStockLiquidationPreference_845ae7cb-1e39-48ee-88a7-1c9038b72e08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_b38ad7b8-17ac-4b47-97f4-d43c18b4aa98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_b38ad7b8-17ac-4b47-97f4-d43c18b4aa98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_99489cb9-2442-4d36-b1cc-946ffdd13529" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_99489cb9-2442-4d36-b1cc-946ffdd13529" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_f7e6714f-ce24-4f42-b81b-58531db07481" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_f7e6714f-ce24-4f42-b81b-58531db07481" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_e88e1937-4ffb-4b39-81b7-51fce566bd1e" xlink:href="agnc-20220930.xsd#agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_e88e1937-4ffb-4b39-81b7-51fce566bd1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_010cf804-ea79-4c53-9867-9200d763bf46" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_190b9809-fb3c-4e34-99cb-691f0ca362cb" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_010cf804-ea79-4c53-9867-9200d763bf46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
