<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:href="agnc-20190930.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:href="agnc-20190930.xsd#ConsolidatedBalanceSheetsParentheticals" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:href="agnc-20190930.xsd#ConsolidatedStatementOfStockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="agnc-20190930.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:href="agnc-20190930.xsd#ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstruments" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:href="agnc-20190930.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurements" xlink:href="agnc-20190930.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:href="agnc-20190930.xsd#FairValueMeasurementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:href="agnc-20190930.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecurities" xlink:href="agnc-20190930.xsd#InvestmentSecurities" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:href="agnc-20190930.xsd#NetIncomeLossPerCommonShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:href="agnc-20190930.xsd#NetIncomeLossPerCommonShareNotes" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:href="agnc-20190930.xsd#NetIncomeLossPerCommonShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/Organization" xlink:href="agnc-20190930.xsd#Organization" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/OrganizationDetails" xlink:href="agnc-20190930.xsd#OrganizationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssets" xlink:href="agnc-20190930.xsd#PledgedAssets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsTables" xlink:href="agnc-20190930.xsd#PledgedAssetsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquity" xlink:href="agnc-20190930.xsd#StockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityLongTermIncentivePlanDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityLongTermIncentivePlanDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityPreferredStockDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityTables" xlink:href="agnc-20190930.xsd#StockholdersEquityTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEvent" xlink:href="agnc-20190930.xsd#SubsequentEvent" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEventDetails" xlink:href="agnc-20190930.xsd#SubsequentEventDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:href="agnc-20190930.xsd#UnauditedInterimConsolidatedFinancialStatements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_7FD016C796365BF8AB790BC03DF335FB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7FD016C796365BF8AB790BC03DF335FB" xlink:to="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_0B0E5A744668536EA6CAEF4382E9D4DD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_0B0E5A744668536EA6CAEF4382E9D4DD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_AFEAF9153F255691BB3B8983B6212421" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_AFEAF9153F255691BB3B8983B6212421" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_3E8323527F6D5B5A90CCFF0CA3D009EE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_3E8323527F6D5B5A90CCFF0CA3D009EE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NonAgencySecuritiesatFairValue" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_1A630FAB151E58799D093F681747E8B9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_1A630FAB151E58799D093F681747E8B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_6863A88048675B6595521177CCAF682B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_6863A88048675B6595521177CCAF682B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_900B6E35EC9B55FB9205DA39C7B448EA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_900B6E35EC9B55FB9205DA39C7B448EA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_266177982B33567AB244542A6AC75D84" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_266177982B33567AB244542A6AC75D84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_EB69BF967A355CB7A07AC4CBFDDA8E8A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_DerivativeAssets_EB69BF967A355CB7A07AC4CBFDDA8E8A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations" xlink:label="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_0F3AEA57D37C541C8DB07F181B884046" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_0F3AEA57D37C541C8DB07F181B884046" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_E1B04CE396815774B3D88F8A6CB2A1F5" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_E1B04CE396815774B3D88F8A6CB2A1F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_089591408EFB547F991E38411498947F" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_089591408EFB547F991E38411498947F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssets" xlink:label="loc_us-gaap_OtherAssets_9678B27488A75F23BF5A33C1670EFE32" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_OtherAssets_9678B27488A75F23BF5A33C1670EFE32" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_08C004E79910528F96413FC9A83D29FB" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_5F8B9C16CD525539B39A9359CC64A991" xlink:to="loc_us-gaap_Assets_08C004E79910528F96413FC9A83D29FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAbstract" xlink:label="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7FD016C796365BF8AB790BC03DF335FB" xlink:to="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_6DDE6FF4BADB57E4BA1E66E6F23C072E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_6DDE6FF4BADB57E4BA1E66E6F23C072E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_841A61A6F12850B9B2B6E5318DD2C38B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_us-gaap_OtherLongTermDebt_841A61A6F12850B9B2B6E5318DD2C38B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:label="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_B626F5850C6D52828794E38B03B19962" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_B626F5850C6D52828794E38B03B19962" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_CB4E974D10E25F18A6B12667E8D7C019" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_us-gaap_DerivativeLiabilities_CB4E974D10E25F18A6B12667E8D7C019" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_C37AB58C07635EEAB8E8DF5BAFD9A2EA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_C37AB58C07635EEAB8E8DF5BAFD9A2EA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_8AC944968C455BC4B43F3A6FA11A4DB5" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_8AC944968C455BC4B43F3A6FA11A4DB5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_C09051644D7F500D9B33B0958E8A7180" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_C09051644D7F500D9B33B0958E8A7180" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_3AD1C638CAD35205BBF34AB8C7DBC6F6" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_960978B6A30059AE95B786E7DE99D531" xlink:to="loc_us-gaap_Liabilities_3AD1C638CAD35205BBF34AB8C7DBC6F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7FD016C796365BF8AB790BC03DF335FB" xlink:to="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_BFACDFDFCEDC5C95B5D941A772ABE9F3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_us-gaap_PreferredStockValue_BFACDFDFCEDC5C95B5D941A772ABE9F3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockBValueIssued" xlink:label="loc_agnc_PreferredStockBValueIssued_B8CC425EB3FB57E88CACAB57C663A7F7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_agnc_PreferredStockBValueIssued_B8CC425EB3FB57E88CACAB57C663A7F7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockCValueIssued" xlink:label="loc_agnc_PreferredStockCValueIssued_8616BAED207657119581D185672C99DF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_agnc_PreferredStockCValueIssued_8616BAED207657119581D185672C99DF" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockDValueIssued" xlink:label="loc_agnc_PreferredStockDValueIssued_D5C0DDC6A40F5A3AB6612D5465B49A16" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_agnc_PreferredStockDValueIssued_D5C0DDC6A40F5A3AB6612D5465B49A16" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_0DB17D4124A45038899360C3E1C9AF95" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_us-gaap_CommonStockValue_0DB17D4124A45038899360C3E1C9AF95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_006A67FB69E950C0B03D5B661FCFB18D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_us-gaap_AdditionalPaidInCapital_006A67FB69E950C0B03D5B661FCFB18D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_1D974AD7A36C585F98BB5C14127BD3D1" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_1D974AD7A36C585F98BB5C14127BD3D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_4BEF1DB797285B1490AC43A2DFCBD07C" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_4BEF1DB797285B1490AC43A2DFCBD07C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_6FFA1C0B4FDD5D35A9436F6222C8F869" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_3684B34FFB5A50548F3DD370F685E575" xlink:to="loc_us-gaap_StockholdersEquity_6FFA1C0B4FDD5D35A9436F6222C8F869" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_2214D02AC1A058B6867744C3AAFDE577" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7FD016C796365BF8AB790BC03DF335FB" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_2214D02AC1A058B6867744C3AAFDE577" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ConsolidatedBalanceSheetsParentheticalAbstract" xlink:label="loc_agnc_ConsolidatedBalanceSheetsParentheticalAbstract_7302B8876E113F66A2C53C80BA1BEB1F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_A821EB9F408B2987719B3C80BA1B3050" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ConsolidatedBalanceSheetsParentheticalAbstract_7302B8876E113F66A2C53C80BA1BEB1F" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_A821EB9F408B2987719B3C80BA1B3050" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_AE7204EF1E96C059F9A23C80BA1B9817" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_A821EB9F408B2987719B3C80BA1B3050" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_AE7204EF1E96C059F9A23C80BA1B9817" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_E9DC3803C03820041EA83C80BA1CDEE6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_AE7204EF1E96C059F9A23C80BA1B9817" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_E9DC3803C03820041EA83C80BA1CDEE6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetPledgedAsCollateralMember" xlink:label="loc_us-gaap_AssetPledgedAsCollateralMember_16442D6BD1BD056609F23C80BA1C82D1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_E9DC3803C03820041EA83C80BA1CDEE6" xlink:to="loc_us-gaap_AssetPledgedAsCollateralMember_16442D6BD1BD056609F23C80BA1C82D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassAxis" xlink:label="loc_invest_InvestmentSecuritiesClassAxis_C281245B752177A3D01A3C80BA1CA765" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_A821EB9F408B2987719B3C80BA1B3050" xlink:to="loc_invest_InvestmentSecuritiesClassAxis_C281245B752177A3D01A3C80BA1CA765" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassDomain" xlink:label="loc_invest_InvestmentSecuritiesClassDomain_6364ECD338A08CB0DB5C3C80BA1D013D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassAxis_C281245B752177A3D01A3C80BA1CA765" xlink:to="loc_invest_InvestmentSecuritiesClassDomain_6364ECD338A08CB0DB5C3C80BA1D013D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_194AAA747DDC1221670D3C80BA1D7099" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_6364ECD338A08CB0DB5C3C80BA1D013D" xlink:to="loc_us-gaap_AgencySecuritiesMember_194AAA747DDC1221670D3C80BA1D7099" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_72E8CD991F7586A6E9B43C80BA1D48DF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_6364ECD338A08CB0DB5C3C80BA1D013D" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_72E8CD991F7586A6E9B43C80BA1D48DF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_9AD3CCC8ED2CDA0069AB3C80BA1DD5BD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_6364ECD338A08CB0DB5C3C80BA1D013D" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_9AD3CCC8ED2CDA0069AB3C80BA1DD5BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_761ABD95ED5C25E02A0E3C80BA1D3587" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_6364ECD338A08CB0DB5C3C80BA1D013D" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_761ABD95ED5C25E02A0E3C80BA1D3587" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReceivableforsecuritiessoldMember" xlink:label="loc_agnc_ReceivableforsecuritiessoldMember_CC3D1A5C843F0AA157C53C80BA1DF38A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_6364ECD338A08CB0DB5C3C80BA1D013D" xlink:to="loc_agnc_ReceivableforsecuritiessoldMember_CC3D1A5C843F0AA157C53C80BA1DF38A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_A821EB9F408B2987719B3C80BA1B3050" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_A44F5D77D832B506690D3C80BA1EF028" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_A44F5D77D832B506690D3C80BA1EF028" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFairValue" xlink:label="loc_us-gaap_DebtInstrumentFairValue_3C5A71D093BF1B05F58B3C80BA1EF971" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_DebtInstrumentFairValue_3C5A71D093BF1B05F58B3C80BA1EF971" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_DE0E6F3B8653789161B53C80BC8244FF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_DE0E6F3B8653789161B53C80BC8244FF" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockBLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue_B9EAB0B3250609FA63583C80BA1EFE5F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_agnc_PreferredStockBLiquidationPreferenceValue_B9EAB0B3250609FA63583C80BA1EFE5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_2FB646DF541B54E0A7A73C80BA1F7FE3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_2FB646DF541B54E0A7A73C80BA1F7FE3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockCLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue_8488C1D751B8191F9A343C80BA1F5281" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_agnc_PreferredStockCLiquidationPreferenceValue_8488C1D751B8191F9A343C80BA1F5281" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockDLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockDLiquidationPreferenceValue_D5BCE7035CFC6BE14A393C80BA1F7984" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_agnc_PreferredStockDLiquidationPreferenceValue_D5BCE7035CFC6BE14A393C80BA1F7984" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_510230EFD58197D6FDFC3C80BA1F8032" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_510230EFD58197D6FDFC3C80BA1F8032" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_0C4098D068787ACD2BDA3C80BA1F38A5" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_0C4098D068787ACD2BDA3C80BA1F38A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_04E155028A970C76528E3C80BA208B6C" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_CommonStockSharesIssued_04E155028A970C76528E3C80BA208B6C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_9BE6EF0436B873C510A33C80BA20F0C6" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_A8C82B01901D749EE8753C80BA1EFCE7" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_9BE6EF0436B873C510A33C80BA20F0C6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_1508A26E4DE7F13715523C6496B81734" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_ED2EF4D8BF8B8D99DDDC3C6496B863BE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_1508A26E4DE7F13715523C6496B81734" xlink:to="loc_us-gaap_StatementTable_ED2EF4D8BF8B8D99DDDC3C6496B863BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_EEEAD15D530E1011083D3C6496B94C48" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_ED2EF4D8BF8B8D99DDDC3C6496B863BE" xlink:to="loc_us-gaap_StatementClassOfStockAxis_EEEAD15D530E1011083D3C6496B94C48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_067A1A2B1500A899E58B3C6496B95E9F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_EEEAD15D530E1011083D3C6496B94C48" xlink:to="loc_us-gaap_ClassOfStockDomain_067A1A2B1500A899E58B3C6496B95E9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_9464647E58CE26CA1CAA3C6496B9F24D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_067A1A2B1500A899E58B3C6496B95E9F" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_9464647E58CE26CA1CAA3C6496B9F24D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_DB490B40AE567BF499973C6496BACDE8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_067A1A2B1500A899E58B3C6496B95E9F" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_DB490B40AE567BF499973C6496BACDE8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_F9C8F32393A0F01A9FBB3C6496BAA31B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_067A1A2B1500A899E58B3C6496B95E9F" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_F9C8F32393A0F01A9FBB3C6496BAA31B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_5BFD5420AB22604CCB6C3C6496BA6555" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_067A1A2B1500A899E58B3C6496B95E9F" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_5BFD5420AB22604CCB6C3C6496BA6555" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_FF549FD5F01DF766D9A93C6496BA6C14" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_ED2EF4D8BF8B8D99DDDC3C6496B863BE" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_FF549FD5F01DF766D9A93C6496BA6C14" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_72BC0DDD1F4CCE2A0B9F3C6496BBD08C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_FF549FD5F01DF766D9A93C6496BA6C14" xlink:to="loc_us-gaap_EquityComponentDomain_72BC0DDD1F4CCE2A0B9F3C6496BBD08C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_C1C821D35EDD82BF26AB3C6496BB0329" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_72BC0DDD1F4CCE2A0B9F3C6496BBD08C" xlink:to="loc_us-gaap_PreferredStockMember_C1C821D35EDD82BF26AB3C6496BB0329" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_5268B9C0BDFF78E043B33C6496BBDADD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_72BC0DDD1F4CCE2A0B9F3C6496BBD08C" xlink:to="loc_us-gaap_CommonStockMember_5268B9C0BDFF78E043B33C6496BBDADD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_71580BBD559FAEE9AA243C6496BBE550" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_72BC0DDD1F4CCE2A0B9F3C6496BBD08C" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_71580BBD559FAEE9AA243C6496BBE550" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_DD58062408E90DAFBC0D3C6496BC9D24" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_72BC0DDD1F4CCE2A0B9F3C6496BBD08C" xlink:to="loc_us-gaap_RetainedEarningsMember_DD58062408E90DAFBC0D3C6496BC9D24" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_4A4A7FCE1F3C633FAB463C6496BC38FF" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_72BC0DDD1F4CCE2A0B9F3C6496BBD08C" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_4A4A7FCE1F3C633FAB463C6496BC38FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_ED2EF4D8BF8B8D99DDDC3C6496B863BE" xlink:to="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_3C85348B25E0ABFB19D43C6496BC9393" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockholdersEquity_3C85348B25E0ABFB19D43C6496BC9393" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_3FFACF5DD87F0F6139D33C6496BC0D07" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_3FFACF5DD87F0F6139D33C6496BC0D07" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_B0E7419550B9FA08B2283C6496BD2C75" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_NetIncomeLoss_B0E7419550B9FA08B2283C6496BD2C75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_07B08DD70C6FC86CE7233C6496BDC46B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_07B08DD70C6FC86CE7233C6496BDC46B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_C5F55CC0B6377592E5343C6496BD1F25" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_07B08DD70C6FC86CE7233C6496BDC46B" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_C5F55CC0B6377592E5343C6496BD1F25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_170877782ED9E468698F3C6496BD7E1D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_07B08DD70C6FC86CE7233C6496BDC46B" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_170877782ED9E468698F3C6496BD7E1D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_63F62BB04A536C7926B83C6496BD483A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_63F62BB04A536C7926B83C6496BD483A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_1ED0DB5643DC500E0F003C6496BE4B2E" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_1ED0DB5643DC500E0F003C6496BE4B2E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_877798BEDEAD8D9D8CB33C649A5896A6" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_877798BEDEAD8D9D8CB33C649A5896A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_163C1F4EA733258D42C73C6496BE4297" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_163C1F4EA733258D42C73C6496BE4297" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_419861595B306F4CC5783C6496BE58A6" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_419861595B306F4CC5783C6496BE58A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_8013BA34CD499B867E763C6496BE5DA7" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_8013BA34CD499B867E763C6496BE5DA7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Issuancecostsofredeemedpreferredstock" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_BB2405DAD22743ED47F13C6496BE4041" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_BB2405DAD22743ED47F13C6496BE4041" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_A14E93ED3A4FE65CB3283C6496BEAC66" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_A14E93ED3A4FE65CB3283C6496BEAC66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_5DED80CE9FCFBDE73B0A3C6496BFF2A2" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_5DED80CE9FCFBDE73B0A3C6496BFF2A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_AAE172BCA90569B6B51F3C6496BF8A82" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_AAE172BCA90569B6B51F3C6496BF8A82" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_CD4A9F6B058E962106FF3C6496BFF35B" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_CD4A9F6B058E962106FF3C6496BFF35B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="loc_us-gaap_DividendsPreferredStockCash_01E594F8C51B800DA3E43C6496BFF47D" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_DividendsPreferredStockCash_01E594F8C51B800DA3E43C6496BFF47D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCommonStockCash" xlink:label="loc_us-gaap_DividendsCommonStockCash_99AD03BD63E3790656023C6496BF8EFC" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_DividendsCommonStockCash_99AD03BD63E3790656023C6496BF8EFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_CAD9DBE5EE00C44B1C593C6496BFF113" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_StockholdersEquity_CAD9DBE5EE00C44B1C593C6496BFF113" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_2617B609855CD932023F3C6496C0E126" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D16E319D6CF2789A930A3C6496BCF700" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_2617B609855CD932023F3C6496C0E126" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_A678FBA9C83EEC96B6AD288B3FF17276" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_A678FBA9C83EEC96B6AD288B3FF17276" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_BB4AD7702BFF73B9DFCB288B3FF19484" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_InterestPaid_BB4AD7702BFF73B9DFCB288B3FF19484" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_E0FA132A647E0A997241288B3FF1A057" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_E0FA132A647E0A997241288B3FF1A057" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_85202A4593CFB8C75CEA288B3FF157A7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_E0FA132A647E0A997241288B3FF1A057" xlink:to="loc_us-gaap_NetIncomeLoss_85202A4593CFB8C75CEA288B3FF157A7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_E0FA132A647E0A997241288B3FF1A057" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_C31A8F24C41A08564DC4288B3FF26814" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_C31A8F24C41A08564DC4288B3FF26814" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_83B83504133259E2F32A288B3FF54A0E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_83B83504133259E2F32A288B3FF54A0E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_01F86307FE49CAFBD2D2288B3FF534F2" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_us-gaap_ShareBasedCompensation_01F86307FE49CAFBD2D2288B3FF534F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_5B2BE537F4F97D1EB1AA288B3FF54EEF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_5B2BE537F4F97D1EB1AA288B3FF54EEF" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome" xlink:label="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_7C382C808F1BABBE3A4A288B3FF697E4" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_7C382C808F1BABBE3A4A288B3FF697E4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_80DB4774B56E9E59D3E1288B3FF6DB88" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_80DB4774B56E9E59D3E1288B3FF6DB88" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_A745E7A0E731568FD319288B3FF608A3" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_A745E7A0E731568FD319288B3FF608A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_EC9B83A5FEF697182400288B3FF68352" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_EC9B83A5FEF697182400288B3FF68352" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_F7E75BA2E9870FD7BEA1288B3FF7A5AB" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C9BD80DE9CFCCCC78F76288B3FF2EF14" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_F7E75BA2E9870FD7BEA1288B3FF7A5AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_5252A7F022C8F4B3AC31288B3FF742D0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_5252A7F022C8F4B3AC31288B3FF742D0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:label="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_D2728883D31E6E0BD1A9288B3FF7E768" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_D2728883D31E6E0BD1A9288B3FF7E768" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_9F35A1DA19B90DE7297A288B3FF7BF46" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_9F35A1DA19B90DE7297A288B3FF7BF46" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities" xlink:label="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_D62FA520688D6143356C288B3FF8EEA4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_D62FA520688D6143356C288B3FF8EEA4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_3246C096B6571E2D6381288B3FF8622D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_3246C096B6571E2D6381288B3FF8622D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:label="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_D23163ED16259E3C10EB288B3FF8D3A8" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_D23163ED16259E3C10EB288B3FF8D3A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_2A602B5763FABF7C3AF8288B3FF8B4F0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_2A602B5763FABF7C3AF8288B3FF8B4F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_F535FDAB391AD9398C1B288B3FF8EE0B" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_F535FDAB391AD9398C1B288B3FF8EE0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:label="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_65C8DAF38F91DEABF7D4288B3FF80553" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_65C8DAF38F91DEABF7D4288B3FF80553" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_AFE0DB88C83A3207A3E0288B3FF8FAF5" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_AFE0DB88C83A3207A3E0288B3FF8FAF5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_CB3A3F3C7232E95426EC288B3FF90264" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_CB3A3F3C7232E95426EC288B3FF90264" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_F160694B19395B37C5A7288B3FF97CA9" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3B0014EA5CCC292A0DED288B3FF7AD9C" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_F160694B19395B37C5A7288B3FF97CA9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_F1D67EE6466376F796B7288B3FF99455" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_F1D67EE6466376F796B7288B3FF99455" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_9A08232393AEBA1E2D74288B3FFAE0E1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_9A08232393AEBA1E2D74288B3FFAE0E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfOtherDebt" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_D8C1378E912C4E91D535288B3FFA4632" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_D8C1378E912C4E91D535288B3FFA4632" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_14C7616EAA1B8BEDBC5F288B3FFA360E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_14C7616EAA1B8BEDBC5F288B3FFA360E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_D64A96A4CE2CEEACC46D288B3FFA9328" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_D64A96A4CE2CEEACC46D288B3FFA9328" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_FDE1FBA4A20D32387B48288B40423879" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_FDE1FBA4A20D32387B48288B40423879" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_542BDEA9A2CC71ABD760288B3FFA2C1C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_PaymentsOfDividends_542BDEA9A2CC71ABD760288B3FFA2C1C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4694F3AD955CA31CB5D6288B3FFB76EE" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_429376219DCCB8F3BAF5288B3FF96E09" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4694F3AD955CA31CB5D6288B3FFB76EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_09C7CAEB6C3C48516649288B3FFB112E" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_09C7CAEB6C3C48516649288B3FFB112E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_020A825E772FCA6F9695288B3FFB7BCE" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_020A825E772FCA6F9695288B3FFB7BCE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_5B47DC246D31105F42A0288B3FFB0CA0" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_C024629157903F9A386C288B3FF07CD4" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_5B47DC246D31105F42A0288B3FFB0CA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_F9DE4F378639E172AFA8288B3FFB328D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_5B47DC246D31105F42A0288B3FFB0CA0" xlink:to="loc_us-gaap_IncomeTaxesPaid_F9DE4F378639E172AFA8288B3FFB328D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_B3D021B57CE55329BA9EFAD58DB49764" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_StatementTable_B3D021B57CE55329BA9EFAD58DB49764" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementScenarioAxis" xlink:label="loc_srt_StatementScenarioAxis_ED3A4C64B61F59AF947BA5D14B2142FF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_B3D021B57CE55329BA9EFAD58DB49764" xlink:to="loc_srt_StatementScenarioAxis_ED3A4C64B61F59AF947BA5D14B2142FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="loc_srt_ScenarioUnspecifiedDomain_77E4D509FAF758C9BB02DBC4E70DC0BD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementScenarioAxis_ED3A4C64B61F59AF947BA5D14B2142FF" xlink:to="loc_srt_ScenarioUnspecifiedDomain_77E4D509FAF758C9BB02DBC4E70DC0BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_3F5E5A3FAD4751B7BB16EB8B2DFFE702" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_B3D021B57CE55329BA9EFAD58DB49764" xlink:to="loc_us-gaap_StatementLineItems_3F5E5A3FAD4751B7BB16EB8B2DFFE702" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Issuancecostsofredeemedpreferredstock" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_A305A885EEC55E0DA3BB3A6DD02C253D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3F5E5A3FAD4751B7BB16EB8B2DFFE702" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_A305A885EEC55E0DA3BB3A6DD02C253D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_2A1CE95E81925A3FB4D6864C64869BAE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3F5E5A3FAD4751B7BB16EB8B2DFFE702" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_2A1CE95E81925A3FB4D6864C64869BAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeExpenseNetAbstract" xlink:label="loc_us-gaap_InterestIncomeExpenseNetAbstract_9C17D8C8AD335ACB935F03DF28B9E3B2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_InterestIncomeExpenseNetAbstract_9C17D8C8AD335ACB935F03DF28B9E3B2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_F4B8B21FD5405BDC9B93F4C6CA8FA12C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_9C17D8C8AD335ACB935F03DF28B9E3B2" xlink:to="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_F4B8B21FD5405BDC9B93F4C6CA8FA12C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_3991890271825920BAEA43EC1A2A7110" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_9C17D8C8AD335ACB935F03DF28B9E3B2" xlink:to="loc_us-gaap_InterestExpense_3991890271825920BAEA43EC1A2A7110" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeExpenseNet" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_EB2657BFAB955BA38EEECEAAA7FC98AF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_9C17D8C8AD335ACB935F03DF28B9E3B2" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_EB2657BFAB955BA38EEECEAAA7FC98AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoninterestIncomeAbstract" xlink:label="loc_us-gaap_NoninterestIncomeAbstract_60797D49361F53C2A6C3BADB6D38DA8A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_NoninterestIncomeAbstract_60797D49361F53C2A6C3BADB6D38DA8A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_319BD38639225F4F90C7A3DE55C3BBEC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_60797D49361F53C2A6C3BADB6D38DA8A" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_319BD38639225F4F90C7A3DE55C3BBEC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_F5945C8CB7955258AB2C1D3513B19EC7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_60797D49361F53C2A6C3BADB6D38DA8A" xlink:to="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_F5945C8CB7955258AB2C1D3513B19EC7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_50F0D1A03D325879A70C3690B8B31B5F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_60797D49361F53C2A6C3BADB6D38DA8A" xlink:to="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_50F0D1A03D325879A70C3690B8B31B5F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ManagementFeeIncome" xlink:label="loc_agnc_ManagementFeeIncome_FE2DA9EFF5225A18A0FF68C8A7E83408" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_60797D49361F53C2A6C3BADB6D38DA8A" xlink:to="loc_agnc_ManagementFeeIncome_FE2DA9EFF5225A18A0FF68C8A7E83408" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoninterestIncome" xlink:label="loc_us-gaap_NoninterestIncome_2510C24CB9BF519BB9797F260686AA27" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_60797D49361F53C2A6C3BADB6D38DA8A" xlink:to="loc_us-gaap_NoninterestIncome_2510C24CB9BF519BB9797F260686AA27" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoninterestExpenseAbstract" xlink:label="loc_us-gaap_NoninterestExpenseAbstract_8470D0E605A759F2A3AC5882F4CD4028" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_NoninterestExpenseAbstract_8470D0E605A759F2A3AC5882F4CD4028" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LaborAndRelatedExpense" xlink:label="loc_us-gaap_LaborAndRelatedExpense_D70DF86131D25AAC9AD073A7D6EF7DC3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_8470D0E605A759F2A3AC5882F4CD4028" xlink:to="loc_us-gaap_LaborAndRelatedExpense_D70DF86131D25AAC9AD073A7D6EF7DC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_3D8884C2812B55209CD59F235DD24944" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_8470D0E605A759F2A3AC5882F4CD4028" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_3D8884C2812B55209CD59F235DD24944" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_DE2E451D592457E8A462EDCE15A104E6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_8470D0E605A759F2A3AC5882F4CD4028" xlink:to="loc_us-gaap_OperatingExpenses_DE2E451D592457E8A462EDCE15A104E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_BE3FDB73E4865A77B77849097DFCAA80" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_NetIncomeLoss_BE3FDB73E4865A77B77849097DFCAA80" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_FA20B06EDBC7578E855D614E0C2F21D8" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_FA20B06EDBC7578E855D614E0C2F21D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_F1765A775A49538FAE001AFD2C5ED280" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_F1765A775A49538FAE001AFD2C5ED280" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_4CA8479834855FE09356BF3659D1D616" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_4CA8479834855FE09356BF3659D1D616" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_3DAB644B591156E095590DCA0C55C54D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_4CA8479834855FE09356BF3659D1D616" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_3DAB644B591156E095590DCA0C55C54D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_5BA5F2A2ABCA5FC8B29226D164167C52" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_5BA5F2A2ABCA5FC8B29226D164167C52" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_81C0B10702455480AC221FE06C0B8FD2" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_81C0B10702455480AC221FE06C0B8FD2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_3DEF946E4665500AA775FBDE2BD687A8" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_3DEF946E4665500AA775FBDE2BD687A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_B5E887F8B9815FB0A037A7A03DB7F444" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_B5E887F8B9815FB0A037A7A03DB7F444" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_B3F1BA1C44CD5E19987D6EFAF31A59FA" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_EarningsPerShareBasic_B3F1BA1C44CD5E19987D6EFAF31A59FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_8996249088DA559584D12701B70B31A5" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_38D399079BE659B4A0D93FA7048B9159" xlink:to="loc_us-gaap_EarningsPerShareDiluted_8996249088DA559584D12701B70B31A5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_946CE7DCC36B57E49250214A52282263" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_USGovernmentFuturesSecuritiesTableTextBlock" xlink:label="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_57D21869C8D05CAD956EACE1B7BC062B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_946CE7DCC36B57E49250214A52282263" xlink:to="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_57D21869C8D05CAD956EACE1B7BC062B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_F738F812720F524E8CB03F363C9F898F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_946CE7DCC36B57E49250214A52282263" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_F738F812720F524E8CB03F363C9F898F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_62F24F6959B20BB93072285858840083" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_62F24F6959B20BB93072285858840083" xlink:to="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_CD638AFECA768CECF01328585889591B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_FinancialInstrumentAxis_CD638AFECA768CECF01328585889591B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_32552C5B141D4DBB888B285858893399" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_CD638AFECA768CECF01328585889591B" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_32552C5B141D4DBB888B285858893399" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_75D4D7B5B1C44C056048285858890244" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_32552C5B141D4DBB888B285858893399" xlink:to="loc_us-gaap_FutureMember_75D4D7B5B1C44C056048285858890244" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_EE3DE615724B0A53BBA92858588A6FA6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_PositionAxis_EE3DE615724B0A53BBA92858588A6FA6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_58D74FF8D022F5F096382858588A885B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_EE3DE615724B0A53BBA92858588A6FA6" xlink:to="loc_us-gaap_PositionDomain_58D74FF8D022F5F096382858588A885B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_0967F77D5130B733D55D2858588A87C3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_58D74FF8D022F5F096382858588A885B" xlink:to="loc_us-gaap_ShortMember_0967F77D5130B733D55D2858588A87C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_DF64B1F19B16B3C0C3962858588B013D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_58D74FF8D022F5F096382858588A885B" xlink:to="loc_us-gaap_LongMember_DF64B1F19B16B3C0C3962858588B013D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_A7B800EFA5A8189797122858588B9D5E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_HedgingDesignationAxis_A7B800EFA5A8189797122858588B9D5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_A3D8BE255DD87477D44A2858588BE321" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_A7B800EFA5A8189797122858588B9D5E" xlink:to="loc_us-gaap_HedgingDesignationDomain_A3D8BE255DD87477D44A2858588BE321" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_8FD059736D7905EDA57C2858588CBC8E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_A3D8BE255DD87477D44A2858588BE321" xlink:to="loc_us-gaap_NondesignatedMember_8FD059736D7905EDA57C2858588CBC8E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_E6BD15318D5287364E862858588C9CEB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_InvestmentTypeAxis_E6BD15318D5287364E862858588C9CEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_53EF2297D1135C2D3CC42858588CD092" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_E6BD15318D5287364E862858588C9CEB" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_53EF2297D1135C2D3CC42858588CD092" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_30B3D4019A40DFBA4B782858588C1365" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_53EF2297D1135C2D3CC42858588CD092" xlink:to="loc_agnc_OtherDerivativesMember_30B3D4019A40DFBA4B782858588C1365" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_C3FB0E54D32F9AC1DF3E2858588D9676" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_53EF2297D1135C2D3CC42858588CD092" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_C3FB0E54D32F9AC1DF3E2858588D9676" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_550B0FFD29EA016546AE2858588D3529" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_550B0FFD29EA016546AE2858588D3529" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_550B0FFD29EA016546AE2858588D3529" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PayerSwaptionMember" xlink:label="loc_agnc_PayerSwaptionMember_D1847443EE9C98C5A4682858588DF8A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_agnc_PayerSwaptionMember_D1847443EE9C98C5A4682858588DF8A4" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_us-gaap_FutureMember_75D4D7B5B1C44C056048285858890244" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_50482AADE133FC8CCDFF2858588EA7E5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_us-gaap_InterestRateSwaptionMember_50482AADE133FC8CCDFF2858588EA7E5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_DEBE38B07F642AE332FC2858588E504B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_DEBE38B07F642AE332FC2858588E504B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_AD3EEA63B98C8EDD056F2858588EEDAD" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_AD3EEA63B98C8EDD056F2858588EEDAD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_EE8FC79F01270633B14B2858588EF140" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_us-gaap_InterestRateSwapMember_EE8FC79F01270633B14B2858588EF140" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_CEDB4004544780365BE72858588ED7EF" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_CEDB4004544780365BE72858588ED7EF" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReceiverSwaptionMember" xlink:label="loc_agnc_ReceiverSwaptionMember_9481D2B89290F5D3800F2858588E80E6" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_56FA9DEDC5908EBA75A12858588D135C" xlink:to="loc_agnc_ReceiverSwaptionMember_9481D2B89290F5D3800F2858588E80E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_311EDAFB72D6A45B0DE22858588FA4AE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_311EDAFB72D6A45B0DE22858588FA4AE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_E04CAF1B0DBBFB9ABB822858588F4267" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_311EDAFB72D6A45B0DE22858588FA4AE" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_E04CAF1B0DBBFB9ABB822858588F4267" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_5D6081891E4E1ACF08D12858588F700C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_E04CAF1B0DBBFB9ABB822858588F4267" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_5D6081891E4E1ACF08D12858588F700C" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_E04CAF1B0DBBFB9ABB822858588F4267" xlink:to="loc_us-gaap_InterestRateSwapMember_EE8FC79F01270633B14B2858588EF140" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_E04CAF1B0DBBFB9ABB822858588F4267" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_AD3EEA63B98C8EDD056F2858588EEDAD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_B04064FB672B7CD656BF28585890FC04" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_E04CAF1B0DBBFB9ABB822858588F4267" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_B04064FB672B7CD656BF28585890FC04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_995EAB8182E5CEA827E72858589001A4" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_995EAB8182E5CEA827E72858589001A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_80F1F7E81ADDF3BD3D7F2858589090EC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_995EAB8182E5CEA827E72858589001A4" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_80F1F7E81ADDF3BD3D7F2858589090EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_82AC3671B5BBC34165A0285858875AFE" xlink:to="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:label="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_9F5274C95AED8D6A9ACB28585891A995" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:to="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_9F5274C95AED8D6A9ACB28585891A995" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_8E454D259FDBEB2F3D8328585891E85A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_9F5274C95AED8D6A9ACB28585891A995" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_8E454D259FDBEB2F3D8328585891E85A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_A2C5F1A9EBC703ECC9C028585891D603" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_9F5274C95AED8D6A9ACB28585891A995" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_A2C5F1A9EBC703ECC9C028585891D603" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_9A89EC645A6875D4193C2858589296D0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_9F5274C95AED8D6A9ACB28585891A995" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_9A89EC645A6875D4193C2858589296D0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_88E4E40549634989099D28585892BCE7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_9F5274C95AED8D6A9ACB28585891A995" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_88E4E40549634989099D28585892BCE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_E123EF14DEF1D1ECEC10285858926E4C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_E123EF14DEF1D1ECEC10285858926E4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_85C0362C9E2EE4FB640B28585892037A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:to="loc_invest_DerivativeNotionalAmount_85C0362C9E2EE4FB640B28585892037A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecurities" xlink:label="loc_us-gaap_TradingSecurities_D31C7F5AEB1065E149222858589268E5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:to="loc_us-gaap_TradingSecurities_D31C7F5AEB1065E149222858589268E5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TradingSecuritiesAddedDuringthePeriod" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_290CD298D54A254DC9E3285858925BD9" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_290CD298D54A254DC9E3285858925BD9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_525C8B5841A8629F3DCB28585892401A" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_525C8B5841A8629F3DCB28585892401A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_0C6BA10FD7B258632785285858934545" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6FC4E0426A313D89AFAF28585891E1C9" xlink:to="loc_agnc_GainLossOnOtherDebt_0C6BA10FD7B258632785285858934545" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_926BF0853D604EA6E6BF3C321052930B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_926BF0853D604EA6E6BF3C321052930B" xlink:to="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_FBC2B4F061A4D085F8493C3210561EBB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:to="loc_us-gaap_PositionAxis_FBC2B4F061A4D085F8493C3210561EBB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_0FE0BBFAC5F059FBD61C3C321056061D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_FBC2B4F061A4D085F8493C3210561EBB" xlink:to="loc_us-gaap_PositionDomain_0FE0BBFAC5F059FBD61C3C321056061D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_86518AF97CA2D48C10C73C321057FED5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_0FE0BBFAC5F059FBD61C3C321056061D" xlink:to="loc_us-gaap_ShortMember_86518AF97CA2D48C10C73C321057FED5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_0AE68C3B7FD0014E19B73C32105769A0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_0FE0BBFAC5F059FBD61C3C321056061D" xlink:to="loc_us-gaap_LongMember_0AE68C3B7FD0014E19B73C32105769A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_BB75894D14EC931852C93C321058C7C1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:to="loc_us-gaap_HedgingDesignationAxis_BB75894D14EC931852C93C321058C7C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_811E4B7722BDD5980DBF3C321058D33C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_BB75894D14EC931852C93C321058C7C1" xlink:to="loc_us-gaap_HedgingDesignationDomain_811E4B7722BDD5980DBF3C321058D33C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_6194B02985D98A24879D3C32105863DF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_811E4B7722BDD5980DBF3C321058D33C" xlink:to="loc_us-gaap_NondesignatedMember_6194B02985D98A24879D3C32105863DF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_C8D0B995B32BCEC83F453C321059352E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_C8D0B995B32BCEC83F453C321059352E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_54AB8BB0B4F3BE8F24063C321059EE80" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_C8D0B995B32BCEC83F453C321059352E" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_54AB8BB0B4F3BE8F24063C321059EE80" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_ED6DFD828A75FFB276993C32105A0DBD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_54AB8BB0B4F3BE8F24063C321059EE80" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_ED6DFD828A75FFB276993C32105A0DBD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_96A68292CA499C816C9B3C32105A02B0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_54AB8BB0B4F3BE8F24063C321059EE80" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_96A68292CA499C816C9B3C32105A02B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1325256B4BB36EA338963C32105A92C3" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1325256B4BB36EA338963C32105A92C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_CFD0854C165A039DFAEB3C32105A8151" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1325256B4BB36EA338963C32105A92C3" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_CFD0854C165A039DFAEB3C32105A8151" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_F4826F437076EFC77E003C32105BBF00" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_CFD0854C165A039DFAEB3C32105A8151" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_F4826F437076EFC77E003C32105BBF00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_0838CC3740B33CF290693C32105B9989" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_0838CC3740B33CF290693C32105B9989" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_0838CC3740B33CF290693C32105B9989" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_96A68292CA499C816C9B3C32105A02B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_723BE24FE7B9A01E3ED13C32105C0F45" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:to="loc_us-gaap_InterestRateSwapMember_723BE24FE7B9A01E3ED13C32105C0F45" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_47BDEA17AC934E8749EA3C32105C0842" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:to="loc_us-gaap_InterestRateSwaptionMember_47BDEA17AC934E8749EA3C32105C0842" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_2CA900FF4BE5396535453C32105CCE1A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_2CA900FF4BE5396535453C32105CCE1A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_F49FB4A1379C2C42E72E3C32105CFE35" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:to="loc_us-gaap_FutureMember_F49FB4A1379C2C42E72E3C32105CFE35" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4DF56C17EF9D7C23A52C3C32105B0188" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_ED6DFD828A75FFB276993C32105A0DBD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_C81B6F3C85B76D4CE4743C32105D1419" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_C81B6F3C85B76D4CE4743C32105D1419" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4C4D51F892BC828308C53C32105D9748" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_C81B6F3C85B76D4CE4743C32105D1419" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4C4D51F892BC828308C53C32105D9748" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_039868EEA2AC3D4999543C32105DA970" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4C4D51F892BC828308C53C32105D9748" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_039868EEA2AC3D4999543C32105DA970" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_7215D0EE57A998ED7BF23C32105E328C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4C4D51F892BC828308C53C32105D9748" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_7215D0EE57A998ED7BF23C32105E328C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_787E9014ED3A6C1154EF3C3210552331" xlink:to="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_82F3123EA4F60FBBC4F63C32105E3D83" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_82F3123EA4F60FBBC4F63C32105E3D83" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_7EA56629BDF2A49290943C32105E703A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_7EA56629BDF2A49290943C32105E703A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_F29E356D26131D6902183C32105EA70C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_F29E356D26131D6902183C32105EA70C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_FB598D575FB3683238D73C32105FBA5E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_DerivativeAssets_FB598D575FB3683238D73C32105FBA5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_40E9FBEAE3B13AFBBB6A3C32105FB40A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_DerivativeLiabilities_40E9FBEAE3B13AFBBB6A3C32105FB40A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_92E0E2D3EF407A28DB903C32105F631F" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_92E0E2D3EF407A28DB903C32105F631F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations" xlink:label="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_35BD660121A24C42A34B3C32105F110F" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_35BD660121A24C42A34B3C32105F110F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Governmentbondsownedandsoldshortnet" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_13E0486DD559E326DDA53C32105FF137" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_agnc_Governmentbondsownedandsoldshortnet_13E0486DD559E326DDA53C32105FF137" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_2DC235E79F227A05A5D33C32106054E9" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_2DC235E79F227A05A5D33C32106054E9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_598F282344A61072A5C53C321060DD48" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_598F282344A61072A5C53C321060DD48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_4C6D7CDDD201EB2850283C321060C361" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_4C6D7CDDD201EB2850283C321060C361" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecurities" xlink:label="loc_us-gaap_TradingSecurities_A1F6902BA8AA395C53AF3C321060EDF3" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_us-gaap_TradingSecurities_A1F6902BA8AA395C53AF3C321060EDF3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TradingSecuritiesAddedDuringthePeriod" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_6ADF86D5F7EC42BF38713C3210618543" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_6ADF86D5F7EC42BF38713C3210618543" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_F37FF11DC68E74F967503C3210613E8B" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_D0E549E9FE702D323E503C32105EB5C4" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_F37FF11DC68E74F967503C3210613E8B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_2EA37B0326D15CA089D1CEC89436066C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_2EA37B0326D15CA089D1CEC89436066C" xlink:to="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_862CC92A3CBC5141A5AC02DFFF7C1699" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_InvestmentTypeAxis_862CC92A3CBC5141A5AC02DFFF7C1699" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_87E1A5B7E7CF59409757523008755F26" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_862CC92A3CBC5141A5AC02DFFF7C1699" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_87E1A5B7E7CF59409757523008755F26" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_F04585D295E256C78AF11A061D558333" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_87E1A5B7E7CF59409757523008755F26" xlink:to="loc_agnc_OtherDerivativesMember_F04585D295E256C78AF11A061D558333" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_0D093728DC075A4982529B23BA0D53A4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_PositionAxis_0D093728DC075A4982529B23BA0D53A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_D149FDA5DDBE533B9CEAA1ACD85CE175" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_0D093728DC075A4982529B23BA0D53A4" xlink:to="loc_us-gaap_PositionDomain_D149FDA5DDBE533B9CEAA1ACD85CE175" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_2F0629D4C2525EC0B4910E635B465C60" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_D149FDA5DDBE533B9CEAA1ACD85CE175" xlink:to="loc_us-gaap_ShortMember_2F0629D4C2525EC0B4910E635B465C60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_125B8C40FC8F5DF7A8543C500884B399" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_D149FDA5DDBE533B9CEAA1ACD85CE175" xlink:to="loc_us-gaap_LongMember_125B8C40FC8F5DF7A8543C500884B399" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_0328E00705A752B2B3729E5877794A8F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_HedgingDesignationAxis_0328E00705A752B2B3729E5877794A8F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_5734C85494995DDD9FC12EA1DEE92F66" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_0328E00705A752B2B3729E5877794A8F" xlink:to="loc_us-gaap_HedgingDesignationDomain_5734C85494995DDD9FC12EA1DEE92F66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_F4D3F5EA055A533DA4DEEC19B5C9D4A0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_5734C85494995DDD9FC12EA1DEE92F66" xlink:to="loc_us-gaap_NondesignatedMember_F4D3F5EA055A533DA4DEEC19B5C9D4A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_442288FA71FB532187AA985A594CA5B4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_442288FA71FB532187AA985A594CA5B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_DB9F4BB5FA205EB6A402679FACF7007A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_442288FA71FB532187AA985A594CA5B4" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_DB9F4BB5FA205EB6A402679FACF7007A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_52986EB612AB5F7FBD92F328A3618ECE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_DB9F4BB5FA205EB6A402679FACF7007A" xlink:to="loc_us-gaap_FutureMember_52986EB612AB5F7FBD92F328A3618ECE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_D11D5273F7695DD0BFF0AE8DED24A1EC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_DB9F4BB5FA205EB6A402679FACF7007A" xlink:to="loc_us-gaap_ForwardContractsMember_D11D5273F7695DD0BFF0AE8DED24A1EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_AACBFE090EEE5887A13BB2C5824DBCC1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_DB9F4BB5FA205EB6A402679FACF7007A" xlink:to="loc_us-gaap_InterestRateSwaptionMember_AACBFE090EEE5887A13BB2C5824DBCC1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_4EACCE3ACC3D5EFA92758A501ADFB872" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_DB9F4BB5FA205EB6A402679FACF7007A" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_4EACCE3ACC3D5EFA92758A501ADFB872" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_38A7AF13197E5B5EB2B9BDE4BD20FC09" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_DB9F4BB5FA205EB6A402679FACF7007A" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_38A7AF13197E5B5EB2B9BDE4BD20FC09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_A5CD793F7F1958239D0DDAACC8FB9342" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_442288FA71FB532187AA985A594CA5B4" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_A5CD793F7F1958239D0DDAACC8FB9342" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_CD41AA5DEADB53FEB8F2C257133141C6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_agnc_DerivativePositionAxis_CD41AA5DEADB53FEB8F2C257133141C6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_08577D4C3D485AB3817D60F00C0C480F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_CD41AA5DEADB53FEB8F2C257133141C6" xlink:to="loc_agnc_DerivativePositionDomain_08577D4C3D485AB3817D60F00C0C480F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_B2FBAA39369057DC8CD3A117456AB189" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_08577D4C3D485AB3817D60F00C0C480F" xlink:to="loc_us-gaap_InterestRateSwapMember_B2FBAA39369057DC8CD3A117456AB189" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_BB7961C14F9E5C8F99933EAAFD8D9846" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_BB7961C14F9E5C8F99933EAAFD8D9846" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_8A1B35BC55AD5D7F994A4E9D0B24BB1A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_BB7961C14F9E5C8F99933EAAFD8D9846" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_8A1B35BC55AD5D7F994A4E9D0B24BB1A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_BF40ABEDA7105B639F60F54F617B8F94" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_8A1B35BC55AD5D7F994A4E9D0B24BB1A" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_BF40ABEDA7105B639F60F54F617B8F94" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_C5767FFD529159EFA146625F474CE41C" xlink:type="locator" />
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_C5767FFD529159EFA146625F474CE41C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_71BD1D1E8AA65EE78F4295E779C29085" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_C5767FFD529159EFA146625F474CE41C" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_71BD1D1E8AA65EE78F4295E779C29085" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_38680B37FA825A72A29F0454C5ADAD33" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_71BD1D1E8AA65EE78F4295E779C29085" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_38680B37FA825A72A29F0454C5ADAD33" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_18309A22D55A57ED9CC159F02E470D21" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_18309A22D55A57ED9CC159F02E470D21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11CF0763D823584797E2B619B977A9D5" xlink:to="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_5C515E0B5D3252B6882AFD4354070FF0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_GainLossOnOtherDebt_5C515E0B5D3252B6882AFD4354070FF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_D2FED50B6E5A5B52AC80A0566B1AC186" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_D2FED50B6E5A5B52AC80A0566B1AC186" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_0B25BAD7FA94555BA8BD7DBA02D9E647" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_0B25BAD7FA94555BA8BD7DBA02D9E647" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_8973F290F8C55612AFAF45FE2147EDBA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_8973F290F8C55612AFAF45FE2147EDBA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_DA8392048BDB5901A28C690E32F91447" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_DA8392048BDB5901A28C690E32F91447" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_DF3363CEAD845E2C9C0A7D894F9DBBDE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_DF3363CEAD845E2C9C0A7D894F9DBBDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_9D372AB865BD53FD9FFCDBDB38CB076D" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_9D372AB865BD53FD9FFCDBDB38CB076D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_6DF5F6E4606355BBBC9DE61DACC0AD72" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_6DF5F6E4606355BBBC9DE61DACC0AD72" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_0BB5DBF5A3F4546F898F2A240160962A" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_0BB5DBF5A3F4546F898F2A240160962A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_E30A54A814D3559E9133D8ADE99F4A14" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_E30A54A814D3559E9133D8ADE99F4A14" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_9E1DBC330F0D595A9C9612EF613038ED" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_9E1DBC330F0D595A9C9612EF613038ED" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_3B59E559CAC953C2937C6FF3B22436F6" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_OptionsAtCost_3B59E559CAC953C2937C6FF3B22436F6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_50E73F8AA1B3507D9BD557947DC9B323" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_50E73F8AA1B3507D9BD557947DC9B323" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TradingSecuritiesAddedDuringthePeriod" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_9543E495ABBB599E872E36694D17216F" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_9543E495ABBB599E872E36694D17216F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_79AD5F31B6EF56F9A6EE2EC827787B4F" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_79AD5F31B6EF56F9A6EE2EC827787B4F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecurities" xlink:label="loc_us-gaap_TradingSecurities_E1AABEE48DEA55B890E9D45CE36E0735" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D632564695465D828F7D3BA34AB75115" xlink:to="loc_us-gaap_TradingSecurities_E1AABEE48DEA55B890E9D45CE36E0735" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_F078B783BB975A29BD3CF2D0941C4579" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_F078B783BB975A29BD3CF2D0941C4579" xlink:to="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_D0121D7F5695547D84427917D2315585" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:to="loc_agnc_DerivativePositionAxis_D0121D7F5695547D84427917D2315585" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_6F995E3E31CC571FA8CFBAA3D760C684" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_D0121D7F5695547D84427917D2315585" xlink:to="loc_agnc_DerivativePositionDomain_6F995E3E31CC571FA8CFBAA3D760C684" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_E212C88855845E62940CD88E7FB3C8B6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_E212C88855845E62940CD88E7FB3C8B6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_F18799EA0894542F8CAED2397AEE092A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_E212C88855845E62940CD88E7FB3C8B6" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_F18799EA0894542F8CAED2397AEE092A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:label="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_65523FCBA66E5C7F9EC2314D67E4994A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_F18799EA0894542F8CAED2397AEE092A" xlink:to="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_65523FCBA66E5C7F9EC2314D67E4994A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_32C307980F8B503BB3685648A718A5A6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_32C307980F8B503BB3685648A718A5A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_82B2B35D13125CB7A087C99555264E4F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_32C307980F8B503BB3685648A718A5A6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_82B2B35D13125CB7A087C99555264E4F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_932639996B7D5EA2947B46504A01BC01" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_82B2B35D13125CB7A087C99555264E4F" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_932639996B7D5EA2947B46504A01BC01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_BBC3CFCC019B5930B10EE2AF538E804D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:to="loc_us-gaap_InvestmentTypeAxis_BBC3CFCC019B5930B10EE2AF538E804D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_5F4ED72458445A27972B76E3B96680C3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_BBC3CFCC019B5930B10EE2AF538E804D" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_5F4ED72458445A27972B76E3B96680C3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_BermudanMember" xlink:label="loc_agnc_BermudanMember_535F38D1FA365357B78A840FA6993F77" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_5F4ED72458445A27972B76E3B96680C3" xlink:to="loc_agnc_BermudanMember_535F38D1FA365357B78A840FA6993F77" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_CCBC10380EE75B0FB7EF4B91CF7CE69A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_5F4ED72458445A27972B76E3B96680C3" xlink:to="loc_agnc_OtherDerivativesMember_CCBC10380EE75B0FB7EF4B91CF7CE69A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_B3BC6EDC8F0C5A5FA031800A59E9B278" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:to="loc_agnc_DerivativesByMaturityAxis_B3BC6EDC8F0C5A5FA031800A59E9B278" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_35D164C31DC45505A27DF1DF393B2590" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_B3BC6EDC8F0C5A5FA031800A59E9B278" xlink:to="loc_agnc_DerivativesByMaturityDomain_35D164C31DC45505A27DF1DF393B2590" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_LessThanOrEqualToOneYearMember" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_BECE4C42690954FF9A0229B8C3801DF7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_35D164C31DC45505A27DF1DF393B2590" xlink:to="loc_agnc_LessThanOrEqualToOneYearMember_BECE4C42690954FF9A0229B8C3801DF7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" xlink:label="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_375395B17A115C44B96CBF87BE35A7F3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_35D164C31DC45505A27DF1DF393B2590" xlink:to="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_375395B17A115C44B96CBF87BE35A7F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_D300C9F60BD45152A52B3AD082C01BCA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_D300C9F60BD45152A52B3AD082C01BCA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_CFA67C19E49252BC87617C51E6402F9B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_D300C9F60BD45152A52B3AD082C01BCA" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_CFA67C19E49252BC87617C51E6402F9B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_D2EA45CBFF6A5564B9551787E0753382" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CFA67C19E49252BC87617C51E6402F9B" xlink:to="loc_us-gaap_ForwardContractsMember_D2EA45CBFF6A5564B9551787E0753382" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_583AEB5690D15267AA49628F2F261665" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CFA67C19E49252BC87617C51E6402F9B" xlink:to="loc_us-gaap_InterestRateSwaptionMember_583AEB5690D15267AA49628F2F261665" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PayerSwaptionMember" xlink:label="loc_agnc_PayerSwaptionMember_A3CE72C3F214588289175BEB9FC65495" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CFA67C19E49252BC87617C51E6402F9B" xlink:to="loc_agnc_PayerSwaptionMember_A3CE72C3F214588289175BEB9FC65495" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_0FCA145887DF550D8453EFDF205026E5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CFA67C19E49252BC87617C51E6402F9B" xlink:to="loc_us-gaap_InterestRateSwapMember_0FCA145887DF550D8453EFDF205026E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_158F45DACBD25018BCA2B364C1C76756" xlink:to="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:label="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_05337FD3A8BC511DA85DA9895D5C1797" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_05337FD3A8BC511DA85DA9895D5C1797" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageForwardStartDate" xlink:label="loc_agnc_WeightedAverageForwardStartDate_B14295BCC54B5544AC2068865AFD328B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_agnc_WeightedAverageForwardStartDate_B14295BCC54B5544AC2068865AFD328B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_348712B92DCB599880B94A19A4DE00DD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_348712B92DCB599880B94A19A4DE00DD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_5CDED1092BDB50B5B404935D29A55257" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_agnc_OptionsAtCost_5CDED1092BDB50B5B404935D29A55257" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_F2AFC6980ED85E04911D52B1840464D4" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_F2AFC6980ED85E04911D52B1840464D4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_98E43D360B355D2E93C44305BC80CD70" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_98E43D360B355D2E93C44305BC80CD70" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_050B39FAD1025512BDC3270396621997" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_050B39FAD1025512BDC3270396621997" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_00AEFB8AA7DC529D8BAF0C9086AEC445" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_00AEFB8AA7DC529D8BAF0C9086AEC445" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_1F8F8587D7685448BD3088DC5A488EC4" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_1F8F8587D7685448BD3088DC5A488EC4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_F1F8FE1B65065FCFA494E93F9EAB50B9" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_F1F8FE1B65065FCFA494E93F9EAB50B9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" xlink:label="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_86725C27927F5689BF777A9CA0DFDAB3" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_59FB5D4BD0445F6597A2768C94728591" xlink:to="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_86725C27927F5689BF777A9CA0DFDAB3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_65FD76D5A79A438599A5285B65D56F5C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_65FD76D5A79A438599A5285B65D56F5C" xlink:to="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_737A11268860528C16CE285B65D5A7A6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_737A11268860528C16CE285B65D5A7A6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_770C0B8CC450636CEC7E285B65D52466" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_737A11268860528C16CE285B65D5A7A6" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_770C0B8CC450636CEC7E285B65D52466" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_3091C9C4392111543CD0285B65D6CDD1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_3091C9C4392111543CD0285B65D6CDD1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_7909AE7B295D7BFC656B285B65D6DF88" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_3091C9C4392111543CD0285B65D6CDD1" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_7909AE7B295D7BFC656B285B65D6DF88" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_35E9F4EB314F477FF06C285B65D6C940" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_7909AE7B295D7BFC656B285B65D6DF88" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_35E9F4EB314F477FF06C285B65D6C940" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_AC538407B397278E8500285B65D7F415" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_us-gaap_InvestmentTypeAxis_AC538407B397278E8500285B65D7F415" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_7F576863F47256D0BB98285B65D75CE8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_AC538407B397278E8500285B65D7F415" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_7F576863F47256D0BB98285B65D75CE8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_2E46926FF760DCBB8EA8285B65D7D08A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_7F576863F47256D0BB98285B65D75CE8" xlink:to="loc_agnc_OtherDerivativesMember_2E46926FF760DCBB8EA8285B65D7D08A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_65D6BCAF1F0003CC9090285B65D7181D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_agnc_DerivativesByMaturityAxis_65D6BCAF1F0003CC9090285B65D7181D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_65D6BCAF1F0003CC9090285B65D7181D" xlink:to="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_LessThanOrEqualToOneYearMember" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_0A5362FDABF23D38C8D2285B65D8445D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_LessThanOrEqualToOneYearMember_0A5362FDABF23D38C8D2285B65D8445D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:label="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_03C91A9BC35482292BF9285B65D8513F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_03C91A9BC35482292BF9285B65D8513F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:label="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_2B2F0A7926345EC66E07285B65D8D8CE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_2B2F0A7926345EC66E07285B65D8D8CE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" xlink:label="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_CB9A8BF132BFE63F960B285B65D8D939" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_CB9A8BF132BFE63F960B285B65D8D939" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_07BE86CE007370984AAD285B65D99BDD" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_07BE86CE007370984AAD285B65D99BDD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:label="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_41C25024418F2D4DF0F6285B65D98894" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_41C25024418F2D4DF0F6285B65D98894" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" xlink:label="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_B35481BF4C31043061FE285B65D9E7C0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_B35481BF4C31043061FE285B65D9E7C0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanTenYearsMember" xlink:label="loc_agnc_GreaterThanTenYearsMember_3DB49513C526966EA63F285B65D9F722" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_3605857932C8EE6F6515285B65D71467" xlink:to="loc_agnc_GreaterThanTenYearsMember_3DB49513C526966EA63F285B65D9F722" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_6B6D919C18BDE0566D02285B65DE58C1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_6B6D919C18BDE0566D02285B65DE58C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_8DAA50154411E098C6E9285B65DF061B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_6B6D919C18BDE0566D02285B65DE58C1" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_8DAA50154411E098C6E9285B65DF061B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PayerSwaptionMember" xlink:label="loc_agnc_PayerSwaptionMember_1FA7C872DF9AD01C00E2285B65DF43FF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8DAA50154411E098C6E9285B65DF061B" xlink:to="loc_agnc_PayerSwaptionMember_1FA7C872DF9AD01C00E2285B65DF43FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_C0A3FF5973C7696283BA285B65DF25F3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8DAA50154411E098C6E9285B65DF061B" xlink:to="loc_us-gaap_InterestRateSwaptionMember_C0A3FF5973C7696283BA285B65DF25F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_19F0A299C4327C05A2FA285B65DF3FBF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8DAA50154411E098C6E9285B65DF061B" xlink:to="loc_us-gaap_ForwardContractsMember_19F0A299C4327C05A2FA285B65DF3FBF" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:label="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_6A68181972B42A7D83B0285B65E09511" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8DAA50154411E098C6E9285B65DF061B" xlink:to="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_6A68181972B42A7D83B0285B65E09511" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_7D4F70CEE5E2FCC15F42285B65E06D4C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8DAA50154411E098C6E9285B65DF061B" xlink:to="loc_us-gaap_InterestRateSwapMember_7D4F70CEE5E2FCC15F42285B65E06D4C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_C2797C1A207C6A5BD1C5285B65E0CEED" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_agnc_DerivativePositionAxis_C2797C1A207C6A5BD1C5285B65E0CEED" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_B28A525B3B70584FBB0C285B65E0D0A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_C2797C1A207C6A5BD1C5285B65E0CEED" xlink:to="loc_agnc_DerivativePositionDomain_B28A525B3B70584FBB0C285B65E0D0A4" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_B28A525B3B70584FBB0C285B65E0D0A4" xlink:to="loc_us-gaap_InterestRateSwapMember_7D4F70CEE5E2FCC15F42285B65E06D4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_B78E920D3CFB6AACC81D285B65E11F99" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_B78E920D3CFB6AACC81D285B65E11F99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_833FD57CB2B3CAD80DA5285B65D5E28D" xlink:to="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" xlink:label="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_2D8FDE921869BFA31F1A285B65E28E9F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_2D8FDE921869BFA31F1A285B65E28E9F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_F7B0D3A3C9ACB24994A9285B65E3E541" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_GainLossOnOtherDebt_F7B0D3A3C9ACB24994A9285B65E3E541" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_5F88C4FF307341B8F7BD285B65E38571" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_5F88C4FF307341B8F7BD285B65E38571" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_6FBE5A4A41DF845C005E285B65E3424E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_6FBE5A4A41DF845C005E285B65E3424E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_ECC1186A073A22E73A89285B65E351DE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_ECC1186A073A22E73A89285B65E351DE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_D3882F2E4DEFB0EE408F285B65E395CA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_D3882F2E4DEFB0EE408F285B65E395CA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_0665DD651DC5CD736E6B285B65E3871E" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_OptionsAtCost_0665DD651DC5CD736E6B285B65E3871E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_D4CA03FDC2C2D9BEB0DA285B65E49D35" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_D4CA03FDC2C2D9BEB0DA285B65E49D35" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_021F4583F58D9AB950D9285B65E4AAA7" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_021F4583F58D9AB950D9285B65E4AAA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageVariableInterestRate" xlink:label="loc_us-gaap_DerivativeAverageVariableInterestRate_3F88DBCF0357C5C4736E285B65E457FB" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_us-gaap_DerivativeAverageVariableInterestRate_3F88DBCF0357C5C4736E285B65E457FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_7E19BDB1928E5D9EBF65285B65E4B5F8" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_7E19BDB1928E5D9EBF65285B65E4B5F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_96482F9C37642A77FC7F285B65E44470" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_invest_DerivativeNotionalAmount_96482F9C37642A77FC7F285B65E44470" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageForwardStartDate" xlink:label="loc_agnc_WeightedAverageForwardStartDate_ECEEE0C5292B2871FA51285B65E42F5D" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_WeightedAverageForwardStartDate_ECEEE0C5292B2871FA51285B65E42F5D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:label="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_D7AB3F136AD138887455285B65E43081" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_D7AB3F136AD138887455285B65E43081" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate" xlink:label="loc_agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate_D518E1C835286F1252DC285E4F6EF1A0" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D1B357073AB92BD3886285B65E2F032" xlink:to="loc_agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate_D518E1C835286F1252DC285E4F6EF1A0" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B9D30E9166764571E82B28A2D9F0E0FB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_8D9DFF8A2E29B8B1725F28A2D9F1F657" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B9D30E9166764571E82B28A2D9F0E0FB" xlink:to="loc_us-gaap_DerivativeTable_8D9DFF8A2E29B8B1725F28A2D9F1F657" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_DDDE7D72F1B3F504CDED28A2D9F1092E" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_8D9DFF8A2E29B8B1725F28A2D9F1F657" xlink:to="loc_us-gaap_HedgingDesignationAxis_DDDE7D72F1B3F504CDED28A2D9F1092E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_61CA64BCD48C4BB2E95428A2D9F11AD9" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_DDDE7D72F1B3F504CDED28A2D9F1092E" xlink:to="loc_us-gaap_HedgingDesignationDomain_61CA64BCD48C4BB2E95428A2D9F11AD9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_708CB9C4215CE5257C3F28A2D9F2973A" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_61CA64BCD48C4BB2E95428A2D9F11AD9" xlink:to="loc_us-gaap_NondesignatedMember_708CB9C4215CE5257C3F28A2D9F2973A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_8D9DFF8A2E29B8B1725F28A2D9F1F657" xlink:to="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock" xlink:label="loc_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock_CE2FCC8CAD7729E69E4228A7429535B2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock_CE2FCC8CAD7729E69E4228A7429535B2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_756D6B4C203E75BCB26428A2D9F2F31B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_756D6B4C203E75BCB26428A2D9F2F31B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" xlink:label="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B8329B3DD161FD6BC8FA28A2D9F28F84" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_B8329B3DD161FD6BC8FA28A2D9F28F84" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" xlink:label="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_5566DD9CA8FA28BCEF5328A2D9F208DA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_5566DD9CA8FA28BCEF5328A2D9F208DA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_USgovernmentsecuritiesTableTextBlock" xlink:label="loc_agnc_USgovernmentsecuritiesTableTextBlock_C72A0FE0CAB55EA9212928A2D9F237C2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_USgovernmentsecuritiesTableTextBlock_C72A0FE0CAB55EA9212928A2D9F237C2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_USGovernmentFuturesSecuritiesTableTextBlock" xlink:label="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_3FAFED79B3EE9893AF6628A2D9F332E8" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_3FAFED79B3EE9893AF6628A2D9F332E8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_9A95F8FBF5343902D38728A2D9F30C4C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_9A95F8FBF5343902D38728A2D9F30C4C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_03DE64C42835820683C928A2D9F34285" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_A94732B8683F4491324B28A2D9F24C2D" xlink:to="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_03DE64C42835820683C928A2D9F34285" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_D9AE9CECDC5CF7E968EA3C3477AFA42B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_D9AE9CECDC5CF7E968EA3C3477AFA42B" xlink:to="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeByMaturityYearsAxis" xlink:label="loc_agnc_DerivativeByMaturityYearsAxis_B3A47171FF42D8FF7E323C3477AF7456" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:to="loc_agnc_DerivativeByMaturityYearsAxis_B3A47171FF42D8FF7E323C3477AF7456" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeByMaturityYearsDomain" xlink:label="loc_agnc_DerivativeByMaturityYearsDomain_AF27B312BFC54AF9D6CA3C3477AF37AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsAxis_B3A47171FF42D8FF7E323C3477AF7456" xlink:to="loc_agnc_DerivativeByMaturityYearsDomain_AF27B312BFC54AF9D6CA3C3477AF37AB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A30YearMaturityMember" xlink:label="loc_agnc_A30YearMaturityMember_4EE830C503B34251EDF03C3477B0589E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain_AF27B312BFC54AF9D6CA3C3477AF37AB" xlink:to="loc_agnc_A30YearMaturityMember_4EE830C503B34251EDF03C3477B0589E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A15YearMaturityMember" xlink:label="loc_agnc_A15YearMaturityMember_A7D9A6304285E112401D3C3477B58ABD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain_AF27B312BFC54AF9D6CA3C3477AF37AB" xlink:to="loc_agnc_A15YearMaturityMember_A7D9A6304285E112401D3C3477B58ABD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesbyIssuerAxis" xlink:label="loc_agnc_DerivativesbyIssuerAxis_0E107CA37E37465FD3553C3477B5AE1F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:to="loc_agnc_DerivativesbyIssuerAxis_0E107CA37E37465FD3553C3477B5AE1F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesbyIssuerDomain" xlink:label="loc_agnc_DerivativesbyIssuerDomain_161681BE341EA82BF3A13C3477B6BF37" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerAxis_0E107CA37E37465FD3553C3477B5AE1F" xlink:to="loc_agnc_DerivativesbyIssuerDomain_161681BE341EA82BF3A13C3477B6BF37" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_3FC55D2D86F072B74FA93C3477B665A5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_161681BE341EA82BF3A13C3477B6BF37" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_3FC55D2D86F072B74FA93C3477B665A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_145951092886221567193C3477B6EBF3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_161681BE341EA82BF3A13C3477B6BF37" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_145951092886221567193C3477B6EBF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_41B724DD34024CCA93203C3477B68AD4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_161681BE341EA82BF3A13C3477B6BF37" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_41B724DD34024CCA93203C3477B68AD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_3EC4CAD40084E022537E3C3477B78244" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:to="loc_us-gaap_PositionAxis_3EC4CAD40084E022537E3C3477B78244" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_FE7C22C69D8E3F5F14B93C3477B7EAF1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_3EC4CAD40084E022537E3C3477B78244" xlink:to="loc_us-gaap_PositionDomain_FE7C22C69D8E3F5F14B93C3477B7EAF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_386C49773B6C814D821A3C3477B716DC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_FE7C22C69D8E3F5F14B93C3477B7EAF1" xlink:to="loc_us-gaap_ShortMember_386C49773B6C814D821A3C3477B716DC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_C706DF978FDB49F6B4293C3477B7F7DE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:to="loc_agnc_DerivativePositionAxis_C706DF978FDB49F6B4293C3477B7F7DE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_79D901B7646E7492427F3C3477B80D6B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_C706DF978FDB49F6B4293C3477B7F7DE" xlink:to="loc_agnc_DerivativePositionDomain_79D901B7646E7492427F3C3477B80D6B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A2.5CouponMember" xlink:label="loc_agnc_A2.5CouponMember_5ADE6D8CA2130902A84B3C3477B825F9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_79D901B7646E7492427F3C3477B80D6B" xlink:to="loc_agnc_A2.5CouponMember_5ADE6D8CA2130902A84B3C3477B825F9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A3.0CouponMember" xlink:label="loc_agnc_A3.0CouponMember_A49D37FC6AED3693CB093C3477B89E3B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_79D901B7646E7492427F3C3477B80D6B" xlink:to="loc_agnc_A3.0CouponMember_A49D37FC6AED3693CB093C3477B89E3B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A3.5CouponMember" xlink:label="loc_agnc_A3.5CouponMember_4BBB5CEFA7F93BB7C5693C3477B80397" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_79D901B7646E7492427F3C3477B80D6B" xlink:to="loc_agnc_A3.5CouponMember_4BBB5CEFA7F93BB7C5693C3477B80397" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A4.0CouponMember" xlink:label="loc_agnc_A4.0CouponMember_F4FCB0CAEC038EED69163C3477B86C15" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_79D901B7646E7492427F3C3477B80D6B" xlink:to="loc_agnc_A4.0CouponMember_F4FCB0CAEC038EED69163C3477B86C15" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A4.5CouponMember" xlink:label="loc_agnc_A4.5CouponMember_5CC0D35D71F92B3B981A3C3477BEA8AD" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_79D901B7646E7492427F3C3477B80D6B" xlink:to="loc_agnc_A4.5CouponMember_5CC0D35D71F92B3B981A3C3477BEA8AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_2044AA6BFC9A2D77577E3C3477BEC179" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_2044AA6BFC9A2D77577E3C3477BEC179" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_2044AA6BFC9A2D77577E3C3477BEC179" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_E9102E777013A18E732E3C3477BEA9EE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_E9102E777013A18E732E3C3477BEA9EE" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:to="loc_agnc_A15YearMaturityMember_A7D9A6304285E112401D3C3477B58ABD" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:to="loc_agnc_A30YearMaturityMember_4EE830C503B34251EDF03C3477B0589E" xlink:type="arc" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_41B724DD34024CCA93203C3477B68AD4" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_145951092886221567193C3477B6EBF3" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_59EF82C0DDC75E3B07B33C3477BEEABD" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_3FC55D2D86F072B74FA93C3477B665A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_2915056F0541C7E51CA63C3477BF19BE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B42B22F52CA8F7A352793C3477AFBB4A" xlink:to="loc_us-gaap_DerivativeLineItems_2915056F0541C7E51CA63C3477BF19BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_0A819FA3125E684FDDE63C3477C0E05D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_2915056F0541C7E51CA63C3477BF19BE" xlink:to="loc_invest_DerivativeNotionalAmount_0A819FA3125E684FDDE63C3477C0E05D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_FE08F54387D07BC31A8E3C3477C0C127" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_2915056F0541C7E51CA63C3477BF19BE" xlink:to="loc_agnc_DerivativeForwardSettlementValue_FE08F54387D07BC31A8E3C3477C0C127" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_D150FBBC977D84F8432E3C3477C03CD2" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_2915056F0541C7E51CA63C3477BF19BE" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_D150FBBC977D84F8432E3C3477C03CD2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_53A53FDAD93C31D2EEB93C3477C0EB87" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_2915056F0541C7E51CA63C3477BF19BE" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_53A53FDAD93C31D2EEB93C3477C0EB87" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_15011E3BD1EF55A295242EECF4AAE7C8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_15011E3BD1EF55A295242EECF4AAE7C8" xlink:to="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_18698F62C5895E75963CB066565ADF3A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_us-gaap_InvestmentTypeAxis_18698F62C5895E75963CB066565ADF3A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_616B6C394D6656AFABFBF99F36168873" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_18698F62C5895E75963CB066565ADF3A" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_616B6C394D6656AFABFBF99F36168873" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_02F2FAE140F5570EA98F82430F314825" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_616B6C394D6656AFABFBF99F36168873" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_02F2FAE140F5570EA98F82430F314825" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_91D90E6BA1D0534EA9E66A996E9FBE2D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_91D90E6BA1D0534EA9E66A996E9FBE2D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_B137097EB92D5E6BBD9A440EDEA14FD0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_91D90E6BA1D0534EA9E66A996E9FBE2D" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_B137097EB92D5E6BBD9A440EDEA14FD0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AtCostBasisMember" xlink:label="loc_agnc_AtCostBasisMember_625519D92A0B58D9AD578E5E10126BE3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_B137097EB92D5E6BBD9A440EDEA14FD0" xlink:to="loc_agnc_AtCostBasisMember_625519D92A0B58D9AD578E5E10126BE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_8EC3A81FA4335B2088AA73622573AD87" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_8EC3A81FA4335B2088AA73622573AD87" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_2D279AF21FE8532BA85BBA34F9F038D3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_8EC3A81FA4335B2088AA73622573AD87" xlink:to="loc_us-gaap_HedgingRelationshipDomain_2D279AF21FE8532BA85BBA34F9F038D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueHedgingMember" xlink:label="loc_us-gaap_FairValueHedgingMember_9354E2DABC92512E9785003E0143E399" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingRelationshipDomain_2D279AF21FE8532BA85BBA34F9F038D3" xlink:to="loc_us-gaap_FairValueHedgingMember_9354E2DABC92512E9785003E0143E399" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_82A5FA00D94D519FA06E03F840B9F72C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_us-gaap_PositionAxis_82A5FA00D94D519FA06E03F840B9F72C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_07CE4F78C2205105859D406A56BEB8FC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_82A5FA00D94D519FA06E03F840B9F72C" xlink:to="loc_us-gaap_PositionDomain_07CE4F78C2205105859D406A56BEB8FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_2C7EE6B3B6595C95AA02F3964A2027DD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_07CE4F78C2205105859D406A56BEB8FC" xlink:to="loc_us-gaap_ShortMember_2C7EE6B3B6595C95AA02F3964A2027DD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_DDBE93CAA3175266B806B25CF0615338" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_07CE4F78C2205105859D406A56BEB8FC" xlink:to="loc_us-gaap_LongMember_DDBE93CAA3175266B806B25CF0615338" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_02DDA019907E54689FE1D74724B7B3D2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_agnc_DerivativesByMaturityAxis_02DDA019907E54689FE1D74724B7B3D2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_4300FAFB697E570B95F3C9BCF03404AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_02DDA019907E54689FE1D74724B7B3D2" xlink:to="loc_agnc_DerivativesByMaturityDomain_4300FAFB697E570B95F3C9BCF03404AB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A10YearMaturityMember" xlink:label="loc_agnc_A10YearMaturityMember_FB33B2A9E93D5A5FAD63645E484C6A08" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_4300FAFB697E570B95F3C9BCF03404AB" xlink:to="loc_agnc_A10YearMaturityMember_FB33B2A9E93D5A5FAD63645E484C6A08" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A5YearMaturityMember" xlink:label="loc_agnc_A5YearMaturityMember_9C09071D5B06596CBA8E46B836627EDA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_4300FAFB697E570B95F3C9BCF03404AB" xlink:to="loc_agnc_A5YearMaturityMember_9C09071D5B06596CBA8E46B836627EDA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_2158D98A470257BEA042953E5AB46039" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_agnc_DerivativePositionAxis_2158D98A470257BEA042953E5AB46039" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_A08558C1E21A59C88201445850E01523" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_2158D98A470257BEA042953E5AB46039" xlink:to="loc_agnc_DerivativePositionDomain_A08558C1E21A59C88201445850E01523" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A2.5CouponMember" xlink:label="loc_agnc_A2.5CouponMember_1B1EB5C3E3245FE6A2533034D8DE82FC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_A08558C1E21A59C88201445850E01523" xlink:to="loc_agnc_A2.5CouponMember_1B1EB5C3E3245FE6A2533034D8DE82FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_EAE9D16648C5571C86CC1A8E961682E8" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_EAE9D16648C5571C86CC1A8E961682E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_EAE9D16648C5571C86CC1A8E961682E8" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A7YearsMaturityMember" xlink:label="loc_agnc_A7YearsMaturityMember_091F222BA9EA50459F6983DD899795BE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_agnc_A7YearsMaturityMember_091F222BA9EA50459F6983DD899795BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_22DC2E4344A452A5937BFC450FDD3684" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_us-gaap_FutureMember_22DC2E4344A452A5937BFC450FDD3684" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A15YearMaturityMember" xlink:label="loc_agnc_A15YearMaturityMember_97350DB4168B5CFB9041B0F9CCF72A69" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_agnc_A15YearMaturityMember_97350DB4168B5CFB9041B0F9CCF72A69" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AtParValueMember" xlink:label="loc_agnc_AtParValueMember_EC53F49D236F5215B137129EE0A12EB7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_agnc_AtParValueMember_EC53F49D236F5215B137129EE0A12EB7" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_agnc_AtCostBasisMember_625519D92A0B58D9AD578E5E10126BE3" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_02F2FAE140F5570EA98F82430F314825" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_B881EDCE995E5307A79164492B3E5A6A" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_B881EDCE995E5307A79164492B3E5A6A" xlink:type="arc" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_agnc_A5YearMaturityMember_9C09071D5B06596CBA8E46B836627EDA" xlink:type="arc" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D1AD2D478E9052949ABF2C2CECBD1462" xlink:to="loc_agnc_A10YearMaturityMember_FB33B2A9E93D5A5FAD63645E484C6A08" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_77CBF5EE0E2F56B6945036B1693A71A2" xlink:to="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_C124C5326C945B3FA5AAB0067754E672" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:to="loc_invest_DerivativeNotionalAmount_C124C5326C945B3FA5AAB0067754E672" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_E632A44081E058F9A5AC836C4A66FD42" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:to="loc_agnc_DerivativeForwardSettlementValue_E632A44081E058F9A5AC836C4A66FD42" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_5195D9F4BF2B588B85B3CEF3EE94121E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_5195D9F4BF2B588B85B3CEF3EE94121E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_2C7E0ABD279A5AEF88CCCDDC2503392E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_2C7E0ABD279A5AEF88CCCDDC2503392E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Governmentbondsownedandsoldshortnet" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_3E2ED5A0CEAB508AA2A29C27DA456737" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:to="loc_agnc_Governmentbondsownedandsoldshortnet_3E2ED5A0CEAB508AA2A29C27DA456737" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageYieldPercentage" xlink:label="loc_agnc_WeightedAverageYieldPercentage_E33792F13AD45BD3B62D866E250B88CD" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_48DB20EF5B1F5B6DA1DCFAAA387B46A0" xlink:to="loc_agnc_WeightedAverageYieldPercentage_E33792F13AD45BD3B62D866E250B88CD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DocumentAndEntityInformationAbstract" xlink:label="loc_agnc_DocumentAndEntityInformationAbstract_A6E4CB493C8329EA4D7392F676B2F163" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntitiesTable" xlink:label="loc_dei_EntitiesTable_0655F5A720D960B0B12592F676B283D4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DocumentAndEntityInformationAbstract_A6E4CB493C8329EA4D7392F676B2F163" xlink:to="loc_dei_EntitiesTable_0655F5A720D960B0B12592F676B283D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_F076D5B8EB7DCE342B8892F676B2F630" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_0655F5A720D960B0B12592F676B283D4" xlink:to="loc_us-gaap_StatementClassOfStockAxis_F076D5B8EB7DCE342B8892F676B2F630" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_DDC3519991C1583C717892F676B21C8F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_F076D5B8EB7DCE342B8892F676B2F630" xlink:to="loc_us-gaap_ClassOfStockDomain_DDC3519991C1583C717892F676B21C8F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_F2422A20E0FE6CB6FE8B92F676B32E7A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_DDC3519991C1583C717892F676B21C8F" xlink:to="loc_us-gaap_CommonStockMember_F2422A20E0FE6CB6FE8B92F676B32E7A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_AF108A6DEA8897EAF01692F676B3DCCC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_DDC3519991C1583C717892F676B21C8F" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_AF108A6DEA8897EAF01692F676B3DCCC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_6950320050941F53AA3892F676B34FEE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_DDC3519991C1583C717892F676B21C8F" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_6950320050941F53AA3892F676B34FEE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_DBDA28654C5D4317C49792F676B36974" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_DDC3519991C1583C717892F676B21C8F" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_DBDA28654C5D4317C49792F676B36974" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_8BC2542CE297D2CF7C3792F677D23475" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_DDC3519991C1583C717892F676B21C8F" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_8BC2542CE297D2CF7C3792F677D23475" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_C9EC145B4205CE40461592F676B4ADC6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_0655F5A720D960B0B12592F676B283D4" xlink:to="loc_dei_LegalEntityAxis_C9EC145B4205CE40461592F676B4ADC6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_32157D41EF61BE8D297892F676B48A42" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_C9EC145B4205CE40461592F676B4ADC6" xlink:to="loc_dei_EntityDomain_32157D41EF61BE8D297892F676B48A42" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityInformationLineItems" xlink:label="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_0655F5A720D960B0B12592F676B283D4" xlink:to="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle" xlink:label="loc_dei_Security12bTitle_B53B5E87CE20887EE17992F676B4A131" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_Security12bTitle_B53B5E87CE20887EE17992F676B4A131" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="loc_dei_EntityIncorporationStateCountryCode_88617EBF478F528A0FDE92F676B55DF6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityIncorporationStateCountryCode_88617EBF478F528A0FDE92F676B55DF6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentTransitionReport" xlink:label="loc_dei_DocumentTransitionReport_633E743184452FDE029392F676B5245A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_DocumentTransitionReport_633E743184452FDE029392F676B5245A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentQuarterlyReport" xlink:label="loc_dei_DocumentQuarterlyReport_D32798445A7E42FB2CCC92F676B5B2F1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_DocumentQuarterlyReport_D32798445A7E42FB2CCC92F676B5B2F1" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber" xlink:label="loc_dei_EntityTaxIdentificationNumber_4CE2CA530035616AD4AC92F676B54987" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityTaxIdentificationNumber_4CE2CA530035616AD4AC92F676B54987" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_01C83C279AA59B4DE29592F676B59A2F" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_DocumentType_01C83C279AA59B4DE29592F676B59A2F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_25A8971EF323302DC3BD92F676B6220B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_AmendmentFlag_25A8971EF323302DC3BD92F676B6220B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_E84E2B90CF5FDA92573892F676B67222" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_DocumentPeriodEndDate_E84E2B90CF5FDA92573892F676B67222" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber" xlink:label="loc_dei_EntityFileNumber_74368EC9AA74EE7E920D92F676B6E202" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityFileNumber_74368EC9AA74EE7E920D92F676B6E202" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_F3972E20E03F9A88AC5392F676B6C7CA" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_DocumentFiscalYearFocus_F3972E20E03F9A88AC5392F676B6C7CA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_7C357D861DB9DD38F37A92F676B6FFF1" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_DocumentFiscalPeriodFocus_7C357D861DB9DD38F37A92F676B6FFF1" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_329D31EBB14BC5C5E9B692F676B75896" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityRegistrantName_329D31EBB14BC5C5E9B692F676B75896" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1" xlink:label="loc_dei_EntityAddressAddressLine1_E1A7C9E3BD9EC550C0D092F676B7AF35" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityAddressAddressLine1_E1A7C9E3BD9EC550C0D092F676B7AF35" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown" xlink:label="loc_dei_EntityAddressCityOrTown_2A299D0444E3E570D76E92F676B7827B" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityAddressCityOrTown_2A299D0444E3E570D76E92F676B7827B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince" xlink:label="loc_dei_EntityAddressStateOrProvince_6BBB9F0475513BC0786B92F676B75E51" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityAddressStateOrProvince_6BBB9F0475513BC0786B92F676B75E51" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode" xlink:label="loc_dei_EntityAddressPostalZipCode_BDE76A2E6FF8DB64D71992F676B73594" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityAddressPostalZipCode_BDE76A2E6FF8DB64D71992F676B73594" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode" xlink:label="loc_dei_CityAreaCode_85C663F9D607100C1B6092F676B77E3D" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_CityAreaCode_85C663F9D607100C1B6092F676B77E3D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber" xlink:label="loc_dei_LocalPhoneNumber_0DD245D8D2F818424A5692F676B8582F" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_LocalPhoneNumber_0DD245D8D2F818424A5692F676B8582F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_F69985093AB19DBA5F9992F676B8770E" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityCentralIndexKey_F69985093AB19DBA5F9992F676B8770E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_16BA2133E1827B15507C92F676B8E6A8" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityFilerCategory_16BA2133E1827B15507C92F676B8E6A8" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntitySmallBusiness" xlink:label="loc_dei_EntitySmallBusiness_374C7395902712C6D32292F676B88911" xlink:type="locator" />
    <link:presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntitySmallBusiness_374C7395902712C6D32292F676B88911" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_B941CC60367368722EA992F676B9ED90" xlink:type="locator" />
    <link:presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityEmergingGrowthCompany_B941CC60367368722EA992F676B9ED90" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_670A932A22128E8EE91F92F676B94CF5" xlink:type="locator" />
    <link:presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_CurrentFiscalYearEndDate_670A932A22128E8EE91F92F676B94CF5" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_5D6D0BBF696F81F75CDF92F676B95219" xlink:type="locator" />
    <link:presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_5D6D0BBF696F81F75CDF92F676B95219" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol" xlink:label="loc_dei_TradingSymbol_7459BC312537F850DA8792F676B942DA" xlink:type="locator" />
    <link:presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_TradingSymbol_7459BC312537F850DA8792F676B942DA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName" xlink:label="loc_dei_SecurityExchangeName_0370B4C3575C1669434492F676B9E9CD" xlink:type="locator" />
    <link:presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_SecurityExchangeName_0370B4C3575C1669434492F676B9E9CD" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_0B95FAEE64586A5F840892F676B9A327" xlink:type="locator" />
    <link:presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_0B95FAEE64586A5F840892F676B9A327" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_CB64D56DDD3363C4F12592F676BA10D3" xlink:type="locator" />
    <link:presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityVoluntaryFilers_CB64D56DDD3363C4F12592F676BA10D3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_0E1A52AC9CE523E5EF9292F676BAFBB2" xlink:type="locator" />
    <link:presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityCurrentReportingStatus_0E1A52AC9CE523E5EF9292F676BAFBB2" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityInteractiveDataCurrent" xlink:label="loc_dei_EntityInteractiveDataCurrent_33AC4DD3D0E005BF720C92F676BA418D" xlink:type="locator" />
    <link:presentationArc order="30" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityInteractiveDataCurrent_33AC4DD3D0E005BF720C92F676BA418D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityShellCompany" xlink:label="loc_dei_EntityShellCompany_8338BD44357022A26DD092F676BAB017" xlink:type="locator" />
    <link:presentationArc order="31" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityShellCompany_8338BD44357022A26DD092F676BAB017" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_93F025272413FD236D9092F676BB2D35" xlink:type="locator" />
    <link:presentationArc order="32" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_D582CAB96FB72B37325892F676B48FCB" xlink:to="loc_dei_EntityPublicFloat_93F025272413FD236D9092F676BB2D35" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_77318470EC2F53DCA8D8D58F54956EBA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_E18379CB6F2757C48ADD6DA860AC9601" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_77318470EC2F53DCA8D8D58F54956EBA" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_E18379CB6F2757C48ADD6DA860AC9601" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_FD7AC7FBA55862560B6A3C4F2A198727" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_FD7AC7FBA55862560B6A3C4F2A198727" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_1884BFB92906E5B71C813C4F2A1A1FBC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_1884BFB92906E5B71C813C4F2A1A1FBC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_865A94B6FFCF4FC441F83C4F2A1A02B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_1884BFB92906E5B71C813C4F2A1A1FBC" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_865A94B6FFCF4FC441F83C4F2A1A02B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_72B2D18670A74B14072A3C4F2A1B2896" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_865A94B6FFCF4FC441F83C4F2A1A02B4" xlink:to="loc_us-gaap_FutureMember_72B2D18670A74B14072A3C4F2A1B2896" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_F22D159440F734B029313C4F2A1B59F6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_865A94B6FFCF4FC441F83C4F2A1A02B4" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_F22D159440F734B029313C4F2A1B59F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_3D16D9A08E1C35AA1FF53C4F2A1B75ED" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_865A94B6FFCF4FC441F83C4F2A1A02B4" xlink:to="loc_us-gaap_InterestRateSwaptionMember_3D16D9A08E1C35AA1FF53C4F2A1B75ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_E407AB8C0DD13CD0B20F3C4F2A1B6D68" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_865A94B6FFCF4FC441F83C4F2A1A02B4" xlink:to="loc_us-gaap_InterestRateSwapMember_E407AB8C0DD13CD0B20F3C4F2A1B6D68" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_4FD1F9262951D916A5633C4F2A1BD30B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_865A94B6FFCF4FC441F83C4F2A1A02B4" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_4FD1F9262951D916A5633C4F2A1BD30B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_8C004464008588BE50033C4F2A1C9700" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_1884BFB92906E5B71C813C4F2A1A1FBC" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_8C004464008588BE50033C4F2A1C9700" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_E13003566064E71D8D503C4F2A1D814F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_E13003566064E71D8D503C4F2A1D814F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_43F6564039363474AD603C4F2A1DFCF2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_E13003566064E71D8D503C4F2A1D814F" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_43F6564039363474AD603C4F2A1DFCF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:label="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_5752D281D4498B241D0A3C4F2A1D22B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_43F6564039363474AD603C4F2A1DFCF2" xlink:to="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_5752D281D4498B241D0A3C4F2A1D22B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6DF8E9BF05FA9A2CC4033C4F2A1E2B87" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6DF8E9BF05FA9A2CC4033C4F2A1E2B87" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_B3F28824169EF9C1FF5A3C4F2A1E1A7D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6DF8E9BF05FA9A2CC4033C4F2A1E2B87" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_B3F28824169EF9C1FF5A3C4F2A1E1A7D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_3A2A5217EDF69B2D91753C4F2A1ED371" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_B3F28824169EF9C1FF5A3C4F2A1E1A7D" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_3A2A5217EDF69B2D91753C4F2A1ED371" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_A1C20554CA1D7366E32D3C4F2A1F505A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_A1C20554CA1D7366E32D3C4F2A1F505A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2D489F52D0103C989D003C4F2A1F1740" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_A1C20554CA1D7366E32D3C4F2A1F505A" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2D489F52D0103C989D003C4F2A1F1740" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_E814CBE6041D565D3E383C4F2A1F8067" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2D489F52D0103C989D003C4F2A1F1740" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_E814CBE6041D565D3E383C4F2A1F8067" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_5AB934A7BDFC4EB5575E3C4F2A1FB791" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2D489F52D0103C989D003C4F2A1F1740" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_5AB934A7BDFC4EB5575E3C4F2A1FB791" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_CC6FF59C2EF818E616A43C4F2A205FE3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_CC6FF59C2EF818E616A43C4F2A205FE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_CC6FF59C2EF818E616A43C4F2A205FE3" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_7B858642C81EE15CF7423C4F2A207B21" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:to="loc_agnc_OtherDerivativesMember_7B858642C81EE15CF7423C4F2A207B21" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:to="loc_us-gaap_InterestRateSwapMember_E407AB8C0DD13CD0B20F3C4F2A1B6D68" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_43245BE99A8ADEC17DCA3C4F2A21AD39" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_43245BE99A8ADEC17DCA3C4F2A21AD39" xlink:type="arc" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:to="loc_us-gaap_FutureMember_72B2D18670A74B14072A3C4F2A1B2896" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_C8DD5BAE55C7C94420063C4F2A21A09F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:to="loc_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_C8DD5BAE55C7C94420063C4F2A21A09F" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_22C3660620241A5174193C4F2A205B9C" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_F22D159440F734B029313C4F2A1B59F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_42E71C2B10F394FDA3863C4F2A211F38" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_42E71C2B10F394FDA3863C4F2A211F38" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_F0602A86C68FF9EE09993C4F2A22FE49" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_42E71C2B10F394FDA3863C4F2A211F38" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_F0602A86C68FF9EE09993C4F2A22FE49" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_F0602A86C68FF9EE09993C4F2A22FE49" xlink:to="loc_us-gaap_InterestRateSwapMember_E407AB8C0DD13CD0B20F3C4F2A1B6D68" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_A85C362B367FE0621E823C4F2A19F9B4" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TransfersBetweenHierarchyLevels" xlink:label="loc_agnc_TransfersBetweenHierarchyLevels_43A62F75714CF71D73193C4F2A221CF0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_agnc_TransfersBetweenHierarchyLevels_43A62F75714CF71D73193C4F2A221CF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_9DFD09358E4D5A3447873C4F2A232924" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_9DFD09358E4D5A3447873C4F2A232924" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_76E28E46CCDADC2F184C3C4F2A23DEE4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_76E28E46CCDADC2F184C3C4F2A23DEE4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NonAgencySecuritiesatFairValue" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_18714E920AED31D439AB3C4F2A235C91" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_18714E920AED31D439AB3C4F2A235C91" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F167D7E9946567A8F0673C4F2A23B95C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F167D7E9946567A8F0673C4F2A23B95C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_8707D6EAC8E795C8D0C83C4F2A23F3B5" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_8707D6EAC8E795C8D0C83C4F2A23F3B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_AE6E1CE227D211DA43863C4F2A24E030" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_AE6E1CE227D211DA43863C4F2A24E030" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_24CA7B9098AEA24269713C4F2A24E346" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_DerivativeAssets_24CA7B9098AEA24269713C4F2A24E346" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_A9C7AACCF8E28F6EACAD3C4F2A246693" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_DerivativeLiabilities_A9C7AACCF8E28F6EACAD3C4F2A246693" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_0479BA19C6647FA6FFD43C4F2A242D77" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_0479BA19C6647FA6FFD43C4F2A242D77" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_23265748823B0286CA5D3C4F2A245723" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_OtherLongTermDebt_23265748823B0286CA5D3C4F2A245723" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_C4C2CE2B82842E2DFFAE3C4F2A24FC5D" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_C4C2CE2B82842E2DFFAE3C4F2A24FC5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_3EB294F93B7D4F0470B43C4F2A251AD6" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_3EB294F93B7D4F0470B43C4F2A251AD6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_6441DAB4989BBF2C65753C4F2A25C3B7" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_442D4D9F547012B627DA3C4F2A22AE8B" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_6441DAB4989BBF2C65753C4F2A25C3B7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_79AA18C4B6265E4F9D19816FEA8BC3C7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_EC1EE0C373A95FEBAC16B3A8958F0DAC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_79AA18C4B6265E4F9D19816FEA8BC3C7" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_EC1EE0C373A95FEBAC16B3A8958F0DAC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecurities" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_91296F20926A5826BA6260DCC9DFE33A" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InvestmentInMortgageBackedSecuritiesTextBlock" xlink:label="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_EC846B5A91DC56959E59C6CD7F3A7328" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_91296F20926A5826BA6260DCC9DFE33A" xlink:to="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_EC846B5A91DC56959E59C6CD7F3A7328" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C884B6D8BF9FFA2C22D328CF59DEC89C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable_6753CC7501DE5D9B153128CF59DE9D4F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C884B6D8BF9FFA2C22D328CF59DEC89C" xlink:to="loc_us-gaap_ScheduleOfInvestmentsTable_6753CC7501DE5D9B153128CF59DE9D4F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_83177815761C14B1B85728CF59DE3EC3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_6753CC7501DE5D9B153128CF59DE9D4F" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_83177815761C14B1B85728CF59DE3EC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_7F970C57902E97C6457028CF59DE1543" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_83177815761C14B1B85728CF59DE3EC3" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_7F970C57902E97C6457028CF59DE1543" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3DEA3431D53A7307466A28CF59DF9B78" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_7F970C57902E97C6457028CF59DE1543" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3DEA3431D53A7307466A28CF59DF9B78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_37E6459C25104E834BBC28CF59DFFCC8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_6753CC7501DE5D9B153128CF59DE9D4F" xlink:to="loc_us-gaap_InvestmentTypeAxis_37E6459C25104E834BBC28CF59DFFCC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_37E6459C25104E834BBC28CF59DFFCC8" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_54D65CEE3453A659A73D28CF59DFECED" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_54D65CEE3453A659A73D28CF59DFECED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_431693E42358167B956C28CF59E077D9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_431693E42358167B956C28CF59E077D9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_74982ECB3C694863B0B728CF59E03D49" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_74982ECB3C694863B0B728CF59E03D49" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_BFD9B77AE24115C00F3528CF59E06A5E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_BFD9B77AE24115C00F3528CF59E06A5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_B30D3DE36BA74EBD924228CF59E0E5EA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_B30D3DE36BA74EBD924228CF59E0E5EA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_B725797ACB7C9FC6C30628CF59E0D3CA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_E266611877F1D894C9AF28CF59DF0464" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_B725797ACB7C9FC6C30628CF59E0D3CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_76799DA17C801B1E351628CF59E1C96D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_6753CC7501DE5D9B153128CF59DE9D4F" xlink:to="loc_us-gaap_FinancialInstrumentAxis_76799DA17C801B1E351628CF59E1C96D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D4A242D5894E78E031CA28CF59E15A8B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_76799DA17C801B1E351628CF59E1C96D" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D4A242D5894E78E031CA28CF59E15A8B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_4D6DE09BB74A9406008D28CF59E16CC6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D4A242D5894E78E031CA28CF59E15A8B" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_4D6DE09BB74A9406008D28CF59E16CC6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TradingSecuritiesMember" xlink:label="loc_agnc_TradingSecuritiesMember_27E4B5A20DE15E449D8228CF59E1FA2A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D4A242D5894E78E031CA28CF59E15A8B" xlink:to="loc_agnc_TradingSecuritiesMember_27E4B5A20DE15E449D8228CF59E1FA2A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SecuritiesRemeasuredatFairValueMember" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_E497C457209A2259904028CF59E28962" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D4A242D5894E78E031CA28CF59E15A8B" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_E497C457209A2259904028CF59E28962" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_6753CC7501DE5D9B153128CF59DE9D4F" xlink:to="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_2A6582C7933CD2E811EC28CF59E26170" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_2A6582C7933CD2E811EC28CF59E26170" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AvailableForSaleSecuritiesPar" xlink:label="loc_agnc_AvailableForSaleSecuritiesPar_95BD772865644C7655D128CF59E26811" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_agnc_AvailableForSaleSecuritiesPar_95BD772865644C7655D128CF59E26811" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_BCCCF05C6ECB1ACF51C228CF59E37AF8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_BCCCF05C6ECB1ACF51C228CF59E37AF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium_A44AAD8A55337507671628CF59E31AB5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedPremium_A44AAD8A55337507671628CF59E31AB5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingUnrealizedGain" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedGain_A606C50137AC4B3CC32728CF59E3A090" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_DebtSecuritiesTradingUnrealizedGain_A606C50137AC4B3CC32728CF59E3A090" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingUnrealizedLoss" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss_1E6B0788D1CFFC8BE82728CF59E38C5D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss_1E6B0788D1CFFC8BE82728CF59E38C5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecuritiesDebt" xlink:label="loc_us-gaap_TradingSecuritiesDebt_627B9B749EA28800B52C28CF59E3585F" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_TradingSecuritiesDebt_627B9B749EA28800B52C28CF59E3585F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_92F136382FEB9629B0C028CF59E324B8" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_92F136382FEB9629B0C028CF59E324B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_24FF98EF39F33E783E7E28CF59E304B1" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_24FF98EF39F33E783E7E28CF59E304B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecuritiesCost" xlink:label="loc_us-gaap_TradingSecuritiesCost_D20775F6D6981FF7FB7628CF59E4941E" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_TradingSecuritiesCost_D20775F6D6981FF7FB7628CF59E4941E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_8B75AA2ACCA76EBD08ED28CF59E4ADE8" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_8B75AA2ACCA76EBD08ED28CF59E4ADE8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_7A9954639B067049088628CF59E45F03" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_7A9954639B067049088628CF59E45F03" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_00922B99DEA53EC0405028CF59E4AF44" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_00922B99DEA53EC0405028CF59E4AF44" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TradingSecuritiesPar" xlink:label="loc_agnc_TradingSecuritiesPar_872A26BFE61EFD6C9CAF28CF59E49835" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_agnc_TradingSecuritiesPar_872A26BFE61EFD6C9CAF28CF59E49835" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_54D26736ABA08F43B74528CF59E569A2" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_54D26736ABA08F43B74528CF59E569A2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageYieldPercentage" xlink:label="loc_agnc_WeightedAverageYieldPercentage_C70FDB83FBAEDCFF894128CF59E51E5C" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_agnc_WeightedAverageYieldPercentage_C70FDB83FBAEDCFF894128CF59E51E5C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_9E64E19E3044F24A129D28CF59E5F1DC" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_9E64E19E3044F24A129D28CF59E5F1DC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_MortgageBackedSecuritiesAmortizedCost" xlink:label="loc_agnc_MortgageBackedSecuritiesAmortizedCost_531A5983F37ACF251F3C28CF59E58D05" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_B66E3342066A62AA588E28CF59E29EB6" xlink:to="loc_agnc_MortgageBackedSecuritiesAmortizedCost_531A5983F37ACF251F3C28CF59E58D05" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_D0FD85D510365D4B98EB502E5DB045E3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_10E60F8443B25EC1AA14D0E7096A5E6E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_D0FD85D510365D4B98EB502E5DB045E3" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_10E60F8443B25EC1AA14D0E7096A5E6E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_48F0453829EB5E5CB6BF138574FC38DC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_10E60F8443B25EC1AA14D0E7096A5E6E" xlink:to="loc_us-gaap_FinancialInstrumentAxis_48F0453829EB5E5CB6BF138574FC38DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_48F0453829EB5E5CB6BF138574FC38DC" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FixedIncomeSecuritiesMember" xlink:label="loc_us-gaap_FixedIncomeSecuritiesMember_5058BEFE07BF57C69D89FC7B35E047F5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:to="loc_us-gaap_FixedIncomeSecuritiesMember_5058BEFE07BF57C69D89FC7B35E047F5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AdjustableRateMember" xlink:label="loc_agnc_AdjustableRateMember_C183C163443251CA86FF1E05FB37D888" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:to="loc_agnc_AdjustableRateMember_C183C163443251CA86FF1E05FB37D888" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollateralizedMortgageObligationsMember" xlink:label="loc_us-gaap_CollateralizedMortgageObligationsMember_6C75F5CF0D0D5C9FB408E213DB38B49E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:to="loc_us-gaap_CollateralizedMortgageObligationsMember_6C75F5CF0D0D5C9FB408E213DB38B49E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MultifamilyMember" xlink:label="loc_srt_MultifamilyMember_7405029F1865557CAA4CCEC2FFBD662D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:to="loc_srt_MultifamilyMember_7405029F1865557CAA4CCEC2FFBD662D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_C4A2B2A682D359EA9671DD7C82130211" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_C4A2B2A682D359EA9671DD7C82130211" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_FD1546CC6E855BC09927F952C1AE5A85" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_A8E224488E8F54EF9D445C4B4551D5FE" xlink:to="loc_us-gaap_AgencySecuritiesMember_FD1546CC6E855BC09927F952C1AE5A85" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_7330A2B9314E5092A730369910BC96B2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_10E60F8443B25EC1AA14D0E7096A5E6E" xlink:to="loc_us-gaap_InvestmentTypeAxis_7330A2B9314E5092A730369910BC96B2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_9977B87B7B6F5507A96050DEAB77DBA5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_7330A2B9314E5092A730369910BC96B2" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_9977B87B7B6F5507A96050DEAB77DBA5" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9977B87B7B6F5507A96050DEAB77DBA5" xlink:to="loc_us-gaap_AgencySecuritiesMember_FD1546CC6E855BC09927F952C1AE5A85" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_D6944ED6656C55A4AE4508AC2D23D792" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9977B87B7B6F5507A96050DEAB77DBA5" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_D6944ED6656C55A4AE4508AC2D23D792" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_03574089B3385DB2B844BCD383FC2154" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9977B87B7B6F5507A96050DEAB77DBA5" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_03574089B3385DB2B844BCD383FC2154" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_E8AECAE4B8305B69BE763DFAF09EF4B9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9977B87B7B6F5507A96050DEAB77DBA5" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_E8AECAE4B8305B69BE763DFAF09EF4B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_B86D5F53B0CA53789892C4DAC6F7AC90" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_10E60F8443B25EC1AA14D0E7096A5E6E" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_B86D5F53B0CA53789892C4DAC6F7AC90" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:label="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_1D35BAF4366254F0AD047E093FABCB4E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_B86D5F53B0CA53789892C4DAC6F7AC90" xlink:to="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_1D35BAF4366254F0AD047E093FABCB4E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_95960EB61C2E54AB85B41B6AC9905C65" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_B86D5F53B0CA53789892C4DAC6F7AC90" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_95960EB61C2E54AB85B41B6AC9905C65" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TotalAgencySecurities" xlink:label="loc_agnc_TotalAgencySecurities_11C2848F17B65118BF936EE3A83F87CA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_B86D5F53B0CA53789892C4DAC6F7AC90" xlink:to="loc_agnc_TotalAgencySecurities_11C2848F17B65118BF936EE3A83F87CA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0E63644E696854D280642F0BF7FF0FA1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0E63644E696854D280642F0BF7FF0FA1" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_5587175756635437A5EE67E628F1AF3E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:to="loc_us-gaap_FinancialInstrumentAxis_5587175756635437A5EE67E628F1AF3E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_79FA6FD965A458EFB8E37535A23CE2BB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_5587175756635437A5EE67E628F1AF3E" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_79FA6FD965A458EFB8E37535A23CE2BB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_6EF3E5B931425F8D9CFBA23D5CC50566" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_79FA6FD965A458EFB8E37535A23CE2BB" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_6EF3E5B931425F8D9CFBA23D5CC50566" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_4C8DA244158C5FAFBDA3E8140BE89BF1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:to="loc_srt_RangeAxis_4C8DA244158C5FAFBDA3E8140BE89BF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_973CB38028AD5FCB9E35E7E24E0F7F92" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_4C8DA244158C5FAFBDA3E8140BE89BF1" xlink:to="loc_srt_RangeMember_973CB38028AD5FCB9E35E7E24E0F7F92" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_F33CD25D328A57C1963D7DA014AD95C0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_973CB38028AD5FCB9E35E7E24E0F7F92" xlink:to="loc_srt_MinimumMember_F33CD25D328A57C1963D7DA014AD95C0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_2CB0E5E9BA27520C943B6E4D237D01FA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_973CB38028AD5FCB9E35E7E24E0F7F92" xlink:to="loc_srt_MaximumMember_2CB0E5E9BA27520C943B6E4D237D01FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_D96C58E45520561CA689E5445DE11325" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_D96C58E45520561CA689E5445DE11325" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_C7C239AF2456537BBFFCA4890C87A874" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_D96C58E45520561CA689E5445DE11325" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_C7C239AF2456537BBFFCA4890C87A874" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:label="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_AD14954B456E58F09C5165C665F3F751" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C7C239AF2456537BBFFCA4890C87A874" xlink:to="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_AD14954B456E58F09C5165C665F3F751" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_CBC2753232E05571ABA1B8A886E63287" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_CBC2753232E05571ABA1B8A886E63287" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_A7683C73596A51B9AFFB3B6E9189CA84" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_CBC2753232E05571ABA1B8A886E63287" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_A7683C73596A51B9AFFB3B6E9189CA84" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_C4334619C4A75663BF4D5B84AA79522E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_A7683C73596A51B9AFFB3B6E9189CA84" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_C4334619C4A75663BF4D5B84AA79522E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_BA815DA2E55C5D8F8590F296C3F18F5C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:to="loc_us-gaap_InvestmentTypeAxis_BA815DA2E55C5D8F8590F296C3F18F5C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_0AC170DF68DE52FEAEBC5EAC3D307DAA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_BA815DA2E55C5D8F8590F296C3F18F5C" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_0AC170DF68DE52FEAEBC5EAC3D307DAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_36ED43E07DB55DB8AFE47AD2FFEAD2D6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_0AC170DF68DE52FEAEBC5EAC3D307DAA" xlink:to="loc_us-gaap_AgencySecuritiesMember_36ED43E07DB55DB8AFE47AD2FFEAD2D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_D9C428C6548F59199663F663DF1FDB62" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_0AC170DF68DE52FEAEBC5EAC3D307DAA" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_D9C428C6548F59199663F663DF1FDB62" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_0AC170DF68DE52FEAEBC5EAC3D307DAA" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_6EF3E5B931425F8D9CFBA23D5CC50566" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_4D0ED2592B18536D95FF6CCE1FDAA6E0" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_0AC170DF68DE52FEAEBC5EAC3D307DAA" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_4D0ED2592B18536D95FF6CCE1FDAA6E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E4CF12EDB5A8564886CCEF391CA54A36" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:label="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_133B42D1C6DA5A2B8DD6372983C8E4C0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_133B42D1C6DA5A2B8DD6372983C8E4C0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_F6D03928D3E3595C96E23CAA103AF5F3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_F6D03928D3E3595C96E23CAA103AF5F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_D6C8D56CB34F5399A93B99390081C3C2" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_D6C8D56CB34F5399A93B99390081C3C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_0C605701C26D5FB1844A75284E7A2DEB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_0C605701C26D5FB1844A75284E7A2DEB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_B0A436DBF6505075A1892E7EF24D550F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_B0A436DBF6505075A1892E7EF24D550F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageCouponRate" xlink:label="loc_agnc_WeightedAverageCouponRate_A094F5E2A6425E29A10B798C46691754" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_agnc_WeightedAverageCouponRate_A094F5E2A6425E29A10B798C46691754" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_UnderlyingCollateralCoupon" xlink:label="loc_agnc_UnderlyingCollateralCoupon_5916972CBE845FB9B34CB11662BCEB5F" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_agnc_UnderlyingCollateralCoupon_5916972CBE845FB9B34CB11662BCEB5F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B2E3818438435DECBAB9DDD0B836472D" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_B2E3818438435DECBAB9DDD0B836472D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesHeldAsCollateralAtFairValue" xlink:label="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_B082F37402EB5130AD476D2DF8ED06C9" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_B082F37402EB5130AD476D2DF8ED06C9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_34DB42965FDE5DE4BA23928C4B23FE84" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_34DB42965FDE5DE4BA23928C4B23FE84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_FEA106DAE91750C888590A7E4033B316" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_OtherLongTermDebt_FEA106DAE91750C888590A7E4033B316" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_2B876C4B38145EFEB86046D6A1B79F66" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_2B876C4B38145EFEB86046D6A1B79F66" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FairValueOfCmoSecuritiesDirectlyHeld" xlink:label="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_036038C367E658A894C8766168D2202A" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_036038C367E658A894C8766168D2202A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SecuritizedCmoSecurities" xlink:label="loc_agnc_SecuritizedCmoSecurities_FD4B17C7ED4F51C3A13BAD475B03F2B0" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_agnc_SecuritizedCmoSecurities_FD4B17C7ED4F51C3A13BAD475B03F2B0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" xlink:label="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_C3EBA5A614B35E8EB474B0D731D18A6F" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_C3EBA5A614B35E8EB474B0D731D18A6F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_036D7DAC80855898A9305C07C2005052" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C51EEE835A165488B7C953A76572CB52" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_036D7DAC80855898A9305C07C2005052" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_D33C7764617B5452BF0ED58389098888" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8E2D2CC9A71A56AF9F2F8F16A2FB3CA4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_D33C7764617B5452BF0ED58389098888" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8E2D2CC9A71A56AF9F2F8F16A2FB3CA4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRatingAxis" xlink:label="loc_agnc_CreditRatingAxis_41717561C6645E5CB8670B9F167DA674" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8E2D2CC9A71A56AF9F2F8F16A2FB3CA4" xlink:to="loc_agnc_CreditRatingAxis_41717561C6645E5CB8670B9F167DA674" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRatingDomain" xlink:label="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingAxis_41717561C6645E5CB8670B9F167DA674" xlink:to="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_BBBRatingMember" xlink:label="loc_agnc_BBBRatingMember_91C3F75B60AB51F8ADD59BDA8EC4AFAE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:to="loc_agnc_BBBRatingMember_91C3F75B60AB51F8ADD59BDA8EC4AFAE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_BBRatingMember" xlink:label="loc_agnc_BBRatingMember_67740ACAF6855ABFA21A6F922E635513" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:to="loc_agnc_BBRatingMember_67740ACAF6855ABFA21A6F922E635513" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AAARatingMember" xlink:label="loc_agnc_AAARatingMember_5E9875F58377583FAF050F0979D9C018" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:to="loc_agnc_AAARatingMember_5E9875F58377583FAF050F0979D9C018" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AARatingMember" xlink:label="loc_agnc_AARatingMember_DDAD1EE444005933AF8945BC71163FD1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:to="loc_agnc_AARatingMember_DDAD1EE444005933AF8945BC71163FD1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ARatingMember" xlink:label="loc_agnc_ARatingMember_39789C55DAB15B38BB851816EE381A02" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:to="loc_agnc_ARatingMember_39789C55DAB15B38BB851816EE381A02" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_BRatingMember" xlink:label="loc_agnc_BRatingMember_A4CFF401EA9D58749BE26C3D334F54F7" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:to="loc_agnc_BRatingMember_A4CFF401EA9D58749BE26C3D334F54F7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NotRatedMember" xlink:label="loc_agnc_NotRatedMember_696CEE8579B7542FA621DCADDCCA4B87" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_D677F1B66A595CD4BE2F91EDEB4B612D" xlink:to="loc_agnc_NotRatedMember_696CEE8579B7542FA621DCADDCCA4B87" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_62508B001E965528896CB285F004467A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8E2D2CC9A71A56AF9F2F8F16A2FB3CA4" xlink:to="loc_us-gaap_FinancialInstrumentAxis_62508B001E965528896CB285F004467A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CF541CEF7A3D51E9A39EB4A5AA4D599F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_62508B001E965528896CB285F004467A" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CF541CEF7A3D51E9A39EB4A5AA4D599F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SecuritiesRemeasuredatFairValueMember" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_B1DD8A0A54DE53778980A9CB6B51805B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CF541CEF7A3D51E9A39EB4A5AA4D599F" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_B1DD8A0A54DE53778980A9CB6B51805B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_AFA11E0272835F44A705A56F1C339E6F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CF541CEF7A3D51E9A39EB4A5AA4D599F" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_AFA11E0272835F44A705A56F1C339E6F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember" xlink:label="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_8569CF09468A5FB78D3A0AF972E39B9E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CF541CEF7A3D51E9A39EB4A5AA4D599F" xlink:to="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_8569CF09468A5FB78D3A0AF972E39B9E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_6F8F5D4CF7115E8A8E46ED7ECEEFA968" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8E2D2CC9A71A56AF9F2F8F16A2FB3CA4" xlink:to="loc_us-gaap_InvestmentTypeAxis_6F8F5D4CF7115E8A8E46ED7ECEEFA968" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_611041C7B3E555E7B064AC7DF542471F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_6F8F5D4CF7115E8A8E46ED7ECEEFA968" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_611041C7B3E555E7B064AC7DF542471F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_6973B95E08905085AB478EC8A93FF5E8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_611041C7B3E555E7B064AC7DF542471F" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_6973B95E08905085AB478EC8A93FF5E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_3A0BECDA9C2E509CB79154F840E20CAD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_611041C7B3E555E7B064AC7DF542471F" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_3A0BECDA9C2E509CB79154F840E20CAD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_8376D5E63A97573C87ACE490924FEBE9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_611041C7B3E555E7B064AC7DF542471F" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_8376D5E63A97573C87ACE490924FEBE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_65E1B3D32A8552A7809A82C7EE533352" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8E2D2CC9A71A56AF9F2F8F16A2FB3CA4" xlink:to="loc_srt_RangeAxis_65E1B3D32A8552A7809A82C7EE533352" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_6464F7B5C712589EB03BC13CE9579905" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_65E1B3D32A8552A7809A82C7EE533352" xlink:to="loc_srt_RangeMember_6464F7B5C712589EB03BC13CE9579905" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C27ABBAF367D55A2979B49B87AF152B5" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8E2D2CC9A71A56AF9F2F8F16A2FB3CA4" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C27ABBAF367D55A2979B49B87AF152B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecuritiesDebt" xlink:label="loc_us-gaap_TradingSecuritiesDebt_77274F14315456799BC96BC72AFDAAE0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C27ABBAF367D55A2979B49B87AF152B5" xlink:to="loc_us-gaap_TradingSecuritiesDebt_77274F14315456799BC96BC72AFDAAE0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_8F73F9DBB7005CA1B942AAD4F7FF6478" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_C27ABBAF367D55A2979B49B87AF152B5" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_8F73F9DBB7005CA1B942AAD4F7FF6478" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_8E794E929395A46D4CD128ACC6E4CC80" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E4CEA1ACC72991629CA328ACC6E4D129" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_8E794E929395A46D4CD128ACC6E4CC80" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E4CEA1ACC72991629CA328ACC6E4D129" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_D8B0236B3F3A1F007F6F28ACC6E50472" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E4CEA1ACC72991629CA328ACC6E4D129" xlink:to="loc_us-gaap_FinancialInstrumentAxis_D8B0236B3F3A1F007F6F28ACC6E50472" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_308D4B1238188DFAD0E928ACC6E5FB97" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_D8B0236B3F3A1F007F6F28ACC6E50472" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_308D4B1238188DFAD0E928ACC6E5FB97" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_LessThanorEqualtoThreeYearsMember" xlink:label="loc_agnc_LessThanorEqualtoThreeYearsMember_927F5B1DCA37A1E1421B28ACCAE5F550" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_308D4B1238188DFAD0E928ACC6E5FB97" xlink:to="loc_agnc_LessThanorEqualtoThreeYearsMember_927F5B1DCA37A1E1421B28ACCAE5F550" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_F8C8D4AA7CA76A387A3528ACC6E51E0A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_308D4B1238188DFAD0E928ACC6E5FB97" xlink:to="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_F8C8D4AA7CA76A387A3528ACC6E51E0A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanFiveYearsMember" xlink:label="loc_agnc_GreaterThanFiveYearsMember_E5D2A3A2CEC1C2AC781B28ACC6E62701" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_308D4B1238188DFAD0E928ACC6E5FB97" xlink:to="loc_agnc_GreaterThanFiveYearsMember_E5D2A3A2CEC1C2AC781B28ACC6E62701" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GreaterThanTenYearsMember" xlink:label="loc_agnc_GreaterThanTenYearsMember_69B63DCCC2D2488E714028ACC6E6D007" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_308D4B1238188DFAD0E928ACC6E5FB97" xlink:to="loc_agnc_GreaterThanTenYearsMember_69B63DCCC2D2488E714028ACC6E6D007" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E4CEA1ACC72991629CA328ACC6E4D129" xlink:to="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_CE0B1E7AA2E377A48DCC28ACC6EBE74B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_CE0B1E7AA2E377A48DCC28ACC6EBE74B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_FD81EF4F59635715D4C628ACC6ECB4B4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_FD81EF4F59635715D4C628ACC6ECB4B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_6F8A8F1B7E4E6596E68D28ACC6ECD9D3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:to="loc_us-gaap_AvailableForSaleSecurities_6F8A8F1B7E4E6596E68D28ACC6ECD9D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_F683D05223CD42C9242E28ACC6EC6E85" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_F683D05223CD42C9242E28ACC6EC6E85" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_18A33861FEE44FAA5DCA28ACC6EC8D96" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_18A33861FEE44FAA5DCA28ACC6EC8D96" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_DB1B3FF73B636994766428ACC6EDA8E7" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F8AC747B0EC6DC0C2E7428ACC6E6A30C" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_DB1B3FF73B636994766428ACC6EDA8E7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_762E07CBA3F95850BB86A2DA073AEC5F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_1D181E90797853AE870B5FD08B19A9ED" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_762E07CBA3F95850BB86A2DA073AEC5F" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_1D181E90797853AE870B5FD08B19A9ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_B8AA1FC491EC532482A05211CC6B821E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_1D181E90797853AE870B5FD08B19A9ED" xlink:to="loc_us-gaap_FinancialInstrumentAxis_B8AA1FC491EC532482A05211CC6B821E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5F69028EFE2C5A3485006E0B2A0E44BF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_B8AA1FC491EC532482A05211CC6B821E" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5F69028EFE2C5A3485006E0B2A0E44BF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_4F6AE4585FDA5152883D00CB73342978" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5F69028EFE2C5A3485006E0B2A0E44BF" xlink:to="loc_us-gaap_AgencySecuritiesMember_4F6AE4585FDA5152883D00CB73342978" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_8E7E4A6731ED5490B1AC640B564FDB0F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_1D181E90797853AE870B5FD08B19A9ED" xlink:to="loc_us-gaap_StatementLineItems_8E7E4A6731ED5490B1AC640B564FDB0F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AccumulatedOtherComprehensiveIncomeLossRollForward" xlink:label="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_3C1C4A445008532DB9ABF8D1DCF3344C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8E7E4A6731ED5490B1AC640B564FDB0F" xlink:to="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_3C1C4A445008532DB9ABF8D1DCF3344C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_2AABB0968EF75CD3BDF7171870E5F554" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_3C1C4A445008532DB9ABF8D1DCF3344C" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_2AABB0968EF75CD3BDF7171870E5F554" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_53AF5A991EFC5010ABC9B26BCCC97F5B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_3C1C4A445008532DB9ABF8D1DCF3344C" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_53AF5A991EFC5010ABC9B26BCCC97F5B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_4D716AE9D2D257A0A2CC95B10FB16A0C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_3C1C4A445008532DB9ABF8D1DCF3344C" xlink:to="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_4D716AE9D2D257A0A2CC95B10FB16A0C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_A6BCA9115A4A573685015FF7B02D65CA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_3C1C4A445008532DB9ABF8D1DCF3344C" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_A6BCA9115A4A573685015FF7B02D65CA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6D2E66CDF44951C591AAA8FACA4C2DEB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_BDED49806AA15B609A27A5F880527BFD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6D2E66CDF44951C591AAA8FACA4C2DEB" xlink:to="loc_us-gaap_StatementTable_BDED49806AA15B609A27A5F880527BFD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_105455EC2D8D5D8F9C16BC20764AC725" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_BDED49806AA15B609A27A5F880527BFD" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_105455EC2D8D5D8F9C16BC20764AC725" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_853C1249E9B15711838197CDBAA9CE5B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_105455EC2D8D5D8F9C16BC20764AC725" xlink:to="loc_us-gaap_EquityComponentDomain_853C1249E9B15711838197CDBAA9CE5B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_7D48D6B0FF485DD58741833396C1F2FF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_853C1249E9B15711838197CDBAA9CE5B" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_7D48D6B0FF485DD58741833396C1F2FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_BDED49806AA15B609A27A5F880527BFD" xlink:to="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_0BBDCBD383E95B11B52493ABE340E4AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_0BBDCBD383E95B11B52493ABE340E4AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_D961EB52E00A57DF96F706BC474C1CE5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_D961EB52E00A57DF96F706BC474C1CE5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_C8D9867FF8915B7DB00355AA52FAF84B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_C8D9867FF8915B7DB00355AA52FAF84B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_5ACAFD770DA85A57B63A956D8CA6D092" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_5ACAFD770DA85A57B63A956D8CA6D092" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_6CD623FCEC9B58FE9EAD7633B424D5F7" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_6CD623FCEC9B58FE9EAD7633B424D5F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_BFA05AF8326C58898C321552225D69EF" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A0BE54B36F895EDFB3CF3B0DE0D2AB72" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_BFA05AF8326C58898C321552225D69EF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_E53F3F0BF3075CC6A9A928C763DA34F8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E5E192CC931C582EB7FEF911D290738E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_E53F3F0BF3075CC6A9A928C763DA34F8" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E5E192CC931C582EB7FEF911D290738E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_E2B71409D9485FBDACBD52AD52E79AA8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E5E192CC931C582EB7FEF911D290738E" xlink:to="loc_us-gaap_InvestmentTypeAxis_E2B71409D9485FBDACBD52AD52E79AA8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_7F43798BDC615AC0B5682B50E0F43272" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_E2B71409D9485FBDACBD52AD52E79AA8" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_7F43798BDC615AC0B5682B50E0F43272" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CostandProceedsofInvestmentSecuritiesMember" xlink:label="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_D18A9B04D2C25895ABE119CD7DB860A6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_7F43798BDC615AC0B5682B50E0F43272" xlink:to="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_D18A9B04D2C25895ABE119CD7DB860A6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:label="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_E61578D79C0E5CE2B1B2D550B5C4C54B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_7F43798BDC615AC0B5682B50E0F43272" xlink:to="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_E61578D79C0E5CE2B1B2D550B5C4C54B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_EC25C1ABCE095D6784B2DEE26BB54ECE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E5E192CC931C582EB7FEF911D290738E" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_EC25C1ABCE095D6784B2DEE26BB54ECE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_A7BC564862B15D0BBA0955B9C3B3FF07" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_EC25C1ABCE095D6784B2DEE26BB54ECE" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_A7BC564862B15D0BBA0955B9C3B3FF07" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_DAA4A6F41F1456F78A88BB61560D8688" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_A7BC564862B15D0BBA0955B9C3B3FF07" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_DAA4A6F41F1456F78A88BB61560D8688" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassAxis" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_D18A4F5D24A05E0D99C844BC63052797" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E5E192CC931C582EB7FEF911D290738E" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_D18A4F5D24A05E0D99C844BC63052797" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassDomain" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_7DE626B9849D52AC85237A1BBAA9DAD2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_D18A4F5D24A05E0D99C844BC63052797" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_7DE626B9849D52AC85237A1BBAA9DAD2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_9268DD628C775EBC8369594ADB551517" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_7DE626B9849D52AC85237A1BBAA9DAD2" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_9268DD628C775EBC8369594ADB551517" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SecuritiesRemeasuredatFairValueMember" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_D1A2DB4997F15E8C94995E7268B5F486" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_7DE626B9849D52AC85237A1BBAA9DAD2" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_D1A2DB4997F15E8C94995E7268B5F486" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesAssetsMember" xlink:label="loc_us-gaap_SecuritiesAssetsMember_E5C174F5C6455B30A3F77D06D8FFF772" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_7DE626B9849D52AC85237A1BBAA9DAD2" xlink:to="loc_us-gaap_SecuritiesAssetsMember_E5C174F5C6455B30A3F77D06D8FFF772" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_E5E192CC931C582EB7FEF911D290738E" xlink:to="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_EB6B8EED422A5FADBB4E1714A332DBF1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_agnc_GainLossOnOtherDebt_EB6B8EED422A5FADBB4E1714A332DBF1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CostOfSaleOfAvailableForSaleSecuities" xlink:label="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_6785E5D76DE55EC4AFECD0BEF536725F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_6785E5D76DE55EC4AFECD0BEF536725F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CostofSaleofFairValueOptionSecurities" xlink:label="loc_agnc_CostofSaleofFairValueOptionSecurities_FE2619BA7D8A5C1CBB7465204F197570" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_agnc_CostofSaleofFairValueOptionSecurities_FE2619BA7D8A5C1CBB7465204F197570" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CostofSaleofInvestmentSecurities" xlink:label="loc_agnc_CostofSaleofInvestmentSecurities_7AD82E6097FE5032B081D7C6A8804917" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_agnc_CostofSaleofInvestmentSecurities_7AD82E6097FE5032B081D7C6A8804917" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_1FF6BD11E6B652808B01AF2937DDBDC0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_1FF6BD11E6B652808B01AF2937DDBDC0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7255709F6A7752EC8487C12C910A895B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7255709F6A7752EC8487C12C910A895B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MarketableSecuritiesRealizedGainLoss" xlink:label="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_E9923270488156DEA925C8D075D372B4" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_E9923270488156DEA925C8D075D372B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_0076D3C9A58D51258CEAB0135B0200AA" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_BB430372393F5D34899225DE2DB1FB87" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_0076D3C9A58D51258CEAB0135B0200AA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_696B570A04165D6BA333CBAEC76A0546" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:label="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_A218BF7EFA4E591B886561F714DAF902" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_696B570A04165D6BA333CBAEC76A0546" xlink:to="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_A218BF7EFA4E591B886561F714DAF902" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesTextBlock" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_7A15093E36175306ADF05E935F2861BD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_696B570A04165D6BA333CBAEC76A0546" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_7A15093E36175306ADF05E935F2861BD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ComponentsOfInvestmentSecuritiesTableTextBlock" xlink:label="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_B731BEDCA3685FDE9AC4AA1137DFBAFB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_696B570A04165D6BA333CBAEC76A0546" xlink:to="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_B731BEDCA3685FDE9AC4AA1137DFBAFB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" xlink:label="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_936DB8158F8F5BC9A18236EBC6066452" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_696B570A04165D6BA333CBAEC76A0546" xlink:to="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_936DB8158F8F5BC9A18236EBC6066452" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" xlink:label="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_7251AFBD8F755F518B84CBD73458EECC" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_696B570A04165D6BA333CBAEC76A0546" xlink:to="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_7251AFBD8F755F518B84CBD73458EECC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock" xlink:label="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_A2F0C1FFAC1758FDAC59DDC2921F890D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_696B570A04165D6BA333CBAEC76A0546" xlink:to="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_A2F0C1FFAC1758FDAC59DDC2921F890D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NetIncomeLossPerCommonShareAbstract" xlink:label="loc_agnc_NetIncomeLossPerCommonShareAbstract_6D6DE06FE04E6F89344F282472864AF4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_EE152E010663FB6122C22824728620E5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_6D6DE06FE04E6F89344F282472864AF4" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_EE152E010663FB6122C22824728620E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C9BA6338E8D568F33BF4282543654B82" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_EE152E010663FB6122C22824728620E5" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C9BA6338E8D568F33BF4282543654B82" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_AEDD6E3FDA831458A6FD2838E0DD1BF3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C9BA6338E8D568F33BF4282543654B82" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_AEDD6E3FDA831458A6FD2838E0DD1BF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_77EC27BBDEED055635F228393A633AAE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_AEDD6E3FDA831458A6FD2838E0DD1BF3" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_77EC27BBDEED055635F228393A633AAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_F7BE46E0CB0726F5FE3C282472863237" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_EE152E010663FB6122C22824728620E5" xlink:to="loc_us-gaap_StatementClassOfStockAxis_F7BE46E0CB0726F5FE3C282472863237" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_248396D45C90B313DBEF2824728638F6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_F7BE46E0CB0726F5FE3C282472863237" xlink:to="loc_us-gaap_ClassOfStockDomain_248396D45C90B313DBEF2824728638F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDilutedLineItems" xlink:label="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_EE152E010663FB6122C22824728620E5" xlink:to="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageNumberofSharesOutstanding" xlink:label="loc_agnc_WeightedAverageNumberofSharesOutstanding_054CD9BEB4A49DEFB532282472875E50" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_agnc_WeightedAverageNumberofSharesOutstanding_054CD9BEB4A49DEFB532282472875E50" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding" xlink:label="loc_agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding_8CCC59FBFF4FBFA16385282472871DF9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding_8CCC59FBFF4FBFA16385282472871DF9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_0EFFE14A7CBAE2D5D545282472872DB8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_0EFFE14A7CBAE2D5D545282472872DB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_2BA921E91308A7854227282D50D26AF2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_2BA921E91308A7854227282D50D26AF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_F4DF2902924CF506C2F5282472880DE0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_F4DF2902924CF506C2F5282472880DE0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_75F3ED04031E1FDA31492824728853AF" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_75F3ED04031E1FDA31492824728853AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_1152886A38CE79E5A71E2824728805E2" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_us-gaap_EarningsPerShareBasic_1152886A38CE79E5A71E2824728805E2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_44F0DC4947ABF950B25228247288B485" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_us-gaap_EarningsPerShareDiluted_44F0DC4947ABF950B25228247288B485" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_5B96C02CA0A00669602728247288C311" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_A1C625BCD8B868F1CECC282472870AA3" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_5B96C02CA0A00669602728247288C311" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NetIncomeLossPerCommonShareAbstract" xlink:label="loc_agnc_NetIncomeLossPerCommonShareAbstract_9999F08D0F755BE58B99907F2240F727" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_08566B29DA71589DBA5E851C4F0B249E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_9999F08D0F755BE58B99907F2240F727" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_08566B29DA71589DBA5E851C4F0B249E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_99FE4AC17C9E54E68E11CE6C3A234D18" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_9999F08D0F755BE58B99907F2240F727" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_99FE4AC17C9E54E68E11CE6C3A234D18" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/Organization" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6ACA32F8D4E15311BCEBCF53135F6CE5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A26B203CFEA25F06811F692F5A0224CF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6ACA32F8D4E15311BCEBCF53135F6CE5" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A26B203CFEA25F06811F692F5A0224CF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_E8ED8A54396E5D27ABB16096E989DD4D" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RequiredAnnualDistributionOfTaxableNetIncome" xlink:label="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_27CB567B10135650B451BDB4EC212912" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_E8ED8A54396E5D27ABB16096E989DD4D" xlink:to="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_27CB567B10135650B451BDB4EC212912" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_IntendedAnnualDistributionofTaxableNetIncome" xlink:label="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_210BD829F37F5A729A0444AE246371CB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_E8ED8A54396E5D27ABB16096E989DD4D" xlink:to="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_210BD829F37F5A729A0444AE246371CB" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssets" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_8450BCE6B15F5EEA9E7E25B4D9045C4B" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsTextBlock" xlink:label="loc_agnc_PledgedAssetsTextBlock_1680EA4350235827BC7FA65AD629386A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_8450BCE6B15F5EEA9E7E25B4D9045C4B" xlink:to="loc_agnc_PledgedAssetsTextBlock_1680EA4350235827BC7FA65AD629386A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_3DE2E0045EEC13A5ED843C763D7D2188" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_E39F831CD03935955B033C763D7D18DB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_3DE2E0045EEC13A5ED843C763D7D2188" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_E39F831CD03935955B033C763D7D18DB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_BAB08204725BBC34C8843C763D7DD742" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_E39F831CD03935955B033C763D7D18DB" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_BAB08204725BBC34C8843C763D7DD742" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2492B4A40E4F36BCB0F63C763D7E6AC8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_BAB08204725BBC34C8843C763D7DD742" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2492B4A40E4F36BCB0F63C763D7E6AC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_3881948FB824766FB1563C763D7E34E3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2492B4A40E4F36BCB0F63C763D7E6AC8" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_3881948FB824766FB1563C763D7E34E3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_UnderPrimeBrokerAgreementsMember" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember_38DAC8825B428951A5E23C763D7E6A7B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2492B4A40E4F36BCB0F63C763D7E6AC8" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_38DAC8825B428951A5E23C763D7E6A7B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ExcludingCashReceivedMember" xlink:label="loc_agnc_ExcludingCashReceivedMember_0A52AC8AD9ECF9828FB13C763D7E1E8F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2492B4A40E4F36BCB0F63C763D7E6AC8" xlink:to="loc_agnc_ExcludingCashReceivedMember_0A52AC8AD9ECF9828FB13C763D7E1E8F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassAxis" xlink:label="loc_invest_InvestmentSecuritiesClassAxis_8230CE540162FF6831883C763D7E9C1F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_E39F831CD03935955B033C763D7D18DB" xlink:to="loc_invest_InvestmentSecuritiesClassAxis_8230CE540162FF6831883C763D7E9C1F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassDomain" xlink:label="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassAxis_8230CE540162FF6831883C763D7E9C1F" xlink:to="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_3881948FB824766FB1563C763D7E34E3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_4D9D0980F81EAFD45C7A3C763D7F7048" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_4D9D0980F81EAFD45C7A3C763D7F7048" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_38DAC8825B428951A5E23C763D7E6A7B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_IncludesSoldButNotYetSettledSecuritiesMember" xlink:label="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0703B23D20581C44141C3C763D802902" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_0703B23D20581C44141C3C763D802902" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_96540B864B582FA449E03C763D80B6BE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_96540B864B582FA449E03C763D80B6BE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NonAgencyMember" xlink:label="loc_agnc_NonAgencyMember_DA7BF521445AE01CEB493C763D80DC35" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_agnc_NonAgencyMember_DA7BF521445AE01CEB493C763D80DC35" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AAANonAgencyMortgageBackedSecuritiesMember" xlink:label="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_EEFE1021C06D6A6216B73C763D80B434" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_EEFE1021C06D6A6216B73C763D80B434" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_3CFBD6AA989535B70A0D3C763D80BDFC" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_3CFBD6AA989535B70A0D3C763D80BDFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeMember" xlink:label="loc_us-gaap_DerivativeMember_00660D071A3D82AB3CA43C763D81261C" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_913FB3872647BE454B3F3C763D7F5185" xlink:to="loc_us-gaap_DerivativeMember_00660D071A3D82AB3CA43C763D81261C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_64CB42AF9112A89319723C763D815CA5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_E39F831CD03935955B033C763D7D18DB" xlink:to="loc_us-gaap_InvestmentTypeAxis_64CB42AF9112A89319723C763D815CA5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_5D9DF57D5C5278F3DA7B3C763D819795" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_64CB42AF9112A89319723C763D815CA5" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_5D9DF57D5C5278F3DA7B3C763D819795" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_5D9DF57D5C5278F3DA7B3C763D819795" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_38DAC8825B428951A5E23C763D7E6A7B" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_5D9DF57D5C5278F3DA7B3C763D819795" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_3881948FB824766FB1563C763D7E34E3" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_5D9DF57D5C5278F3DA7B3C763D819795" xlink:to="loc_us-gaap_DerivativeMember_00660D071A3D82AB3CA43C763D81261C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_E39F831CD03935955B033C763D7D18DB" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_02C7E17564DEE49A9AA13C763D82619C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:to="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_02C7E17564DEE49A9AA13C763D82619C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_847590E1391125ECBCC53C763D83CFFE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:to="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_847590E1391125ECBCC53C763D83CFFE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_C6D2A402931323B2CC013C763D83D750" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_C6D2A402931323B2CC013C763D83D750" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:label="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_C5B86AB9F045C179C33E3C763D83A711" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:to="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_C5B86AB9F045C179C33E3C763D83A711" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_7435AE8DF29E225E04493C763D83BB7A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_7435AE8DF29E225E04493C763D83BB7A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest" xlink:label="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_342438CC35D0C43600413C763D83508B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:to="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_342438CC35D0C43600413C763D83508B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" xlink:label="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_498C53F0D96ACFF5385B3C763D847953" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_8DE0E223A59DAF6787833C763D828A91" xlink:to="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_498C53F0D96ACFF5385B3C763D847953" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_5E2C40D085DE5936B85C2CC062CC5AA9" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_97CC4BE0D95F50929A40292CD85C7324" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_5E2C40D085DE5936B85C2CC062CC5AA9" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_97CC4BE0D95F50929A40292CD85C7324" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_2E27885C6D61500CAEF6A344F9A3EE77" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_97CC4BE0D95F50929A40292CD85C7324" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_2E27885C6D61500CAEF6A344F9A3EE77" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_8DBF4654FB66597C8C06B8E6AE82A05F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_2E27885C6D61500CAEF6A344F9A3EE77" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_8DBF4654FB66597C8C06B8E6AE82A05F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeMember" xlink:label="loc_us-gaap_DerivativeMember_CBEDB86E21D45BD085280A50DE935E46" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_8DBF4654FB66597C8C06B8E6AE82A05F" xlink:to="loc_us-gaap_DerivativeMember_CBEDB86E21D45BD085280A50DE935E46" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_5674055A1D6754A6B115991D8F600F83" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_97CC4BE0D95F50929A40292CD85C7324" xlink:to="loc_us-gaap_InvestmentTypeAxis_5674055A1D6754A6B115991D8F600F83" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_A67C3AAEC0805E28B2B674B56744F3A1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_5674055A1D6754A6B115991D8F600F83" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_A67C3AAEC0805E28B2B674B56744F3A1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReverseRepurchaseAgreementsMember" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_2F41A3D5A54856F493167F63040CE0AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_A67C3AAEC0805E28B2B674B56744F3A1" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_2F41A3D5A54856F493167F63040CE0AB" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_A67C3AAEC0805E28B2B674B56744F3A1" xlink:to="loc_us-gaap_DerivativeMember_CBEDB86E21D45BD085280A50DE935E46" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassAxis" xlink:label="loc_invest_InvestmentSecuritiesClassAxis_142C301027F45E99920B7AB359535021" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_97CC4BE0D95F50929A40292CD85C7324" xlink:to="loc_invest_InvestmentSecuritiesClassAxis_142C301027F45E99920B7AB359535021" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassDomain" xlink:label="loc_invest_InvestmentSecuritiesClassDomain_67FC67ACBA645F519AB746F9EF70B008" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassAxis_142C301027F45E99920B7AB359535021" xlink:to="loc_invest_InvestmentSecuritiesClassDomain_67FC67ACBA645F519AB746F9EF70B008" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_12AACFD538E75EB29A2AB58E2301D15E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_67FC67ACBA645F519AB746F9EF70B008" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_12AACFD538E75EB29A2AB58E2301D15E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_F5FDD11ADC275CACADDEC74D6EF4249F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_67FC67ACBA645F519AB746F9EF70B008" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_F5FDD11ADC275CACADDEC74D6EF4249F" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_67FC67ACBA645F519AB746F9EF70B008" xlink:to="loc_us-gaap_DerivativeMember_CBEDB86E21D45BD085280A50DE935E46" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_955333873FB05E6A83817CC1781E7126" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_67FC67ACBA645F519AB746F9EF70B008" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_955333873FB05E6A83817CC1781E7126" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_67FC67ACBA645F519AB746F9EF70B008" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_2F41A3D5A54856F493167F63040CE0AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_978B236353E8581D97E20A7480D16D93" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_97CC4BE0D95F50929A40292CD85C7324" xlink:to="loc_us-gaap_FinancialInstrumentAxis_978B236353E8581D97E20A7480D16D93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7DC433407203500B846A94282AD817B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_978B236353E8581D97E20A7480D16D93" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7DC433407203500B846A94282AD817B4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AssetsPledgedtoUsMember" xlink:label="loc_agnc_AssetsPledgedtoUsMember_C87FC29A2DF5508B913DB6387BEC2B65" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7DC433407203500B846A94282AD817B4" xlink:to="loc_agnc_AssetsPledgedtoUsMember_C87FC29A2DF5508B913DB6387BEC2B65" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_A9826D9630085BACA7DE3FD224F4699C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_97CC4BE0D95F50929A40292CD85C7324" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_A9826D9630085BACA7DE3FD224F4699C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedMortgageRelatedSecuritiesAvailableForSaleOrHeldForInvestment" xlink:label="loc_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedMortgageRelatedSecuritiesAvailableForSaleOrHeldForInvestment_588A44E668D6520C97AF28E2F2C9B5F8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_A9826D9630085BACA7DE3FD224F4699C" xlink:to="loc_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedMortgageRelatedSecuritiesAvailableForSaleOrHeldForInvestment_588A44E668D6520C97AF28E2F2C9B5F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_3DA867418CCD546C995FB86BBA708FB6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_A9826D9630085BACA7DE3FD224F4699C" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_3DA867418CCD546C995FB86BBA708FB6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_D55EC68688B55774819D55DBE2061406" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_A9826D9630085BACA7DE3FD224F4699C" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_D55EC68688B55774819D55DBE2061406" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_57B3991EE5F25E598EE5BD6AF919DFF8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_A9826D9630085BACA7DE3FD224F4699C" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_57B3991EE5F25E598EE5BD6AF919DFF8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RestrictedCashandSecuritiesPledged" xlink:label="loc_agnc_RestrictedCashandSecuritiesPledged_3643A02E1B665FE19A50B6A26DAAA315" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_A9826D9630085BACA7DE3FD224F4699C" xlink:to="loc_agnc_RestrictedCashandSecuritiesPledged_3643A02E1B665FE19A50B6A26DAAA315" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_B6055458ECC952A98F5BCDD133C2192D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_4F74B497567253DDB51AEE58D7659C70" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_B6055458ECC952A98F5BCDD133C2192D" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_4F74B497567253DDB51AEE58D7659C70" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_CDC92F9B71DE5D0287A4ABEFF767FE4A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_B6055458ECC952A98F5BCDD133C2192D" xlink:to="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_CDC92F9B71DE5D0287A4ABEFF767FE4A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CreditDerivativeMaximumExposureUndiscounted" xlink:label="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_C978B78B76C8510888BE3E45AFCC08E8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_B6055458ECC952A98F5BCDD133C2192D" xlink:to="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_C978B78B76C8510888BE3E45AFCC08E8" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_772B49CF660854648C1DFE46004658A2" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_EB60FF59B46B5BA89714B10D88DAA977" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_772B49CF660854648C1DFE46004658A2" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_EB60FF59B46B5BA89714B10D88DAA977" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_39735DF50F0752CC9B1BEEB5B1EFA258" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_EB60FF59B46B5BA89714B10D88DAA977" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_39735DF50F0752CC9B1BEEB5B1EFA258" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_3FE1932B86D2552B9D0718F29B0C4E34" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_39735DF50F0752CC9B1BEEB5B1EFA258" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_3FE1932B86D2552B9D0718F29B0C4E34" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReverseRepurchaseAgreementsMember" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_69142EDFC6EA5772AA4A7DE991EE9763" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_3FE1932B86D2552B9D0718F29B0C4E34" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_69142EDFC6EA5772AA4A7DE991EE9763" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_4C93458B9A0D5526BDC42A613A36891D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_3FE1932B86D2552B9D0718F29B0C4E34" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_4C93458B9A0D5526BDC42A613A36891D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_9C2271DA7ABE5BD78A9D5788A78180B5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_EB60FF59B46B5BA89714B10D88DAA977" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_9C2271DA7ABE5BD78A9D5788A78180B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3EC985D763D55A3396C29FF9BDE491F3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_9C2271DA7ABE5BD78A9D5788A78180B5" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3EC985D763D55A3396C29FF9BDE491F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsMember" xlink:label="loc_us-gaap_AssetsMember_15BAF59109F5523B9443E6B25DC92AB2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3EC985D763D55A3396C29FF9BDE491F3" xlink:to="loc_us-gaap_AssetsMember_15BAF59109F5523B9443E6B25DC92AB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilityMember" xlink:label="loc_us-gaap_LiabilityMember_0B8D1E5EA1125D4AB19C84E5D52C76F4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3EC985D763D55A3396C29FF9BDE491F3" xlink:to="loc_us-gaap_LiabilityMember_0B8D1E5EA1125D4AB19C84E5D52C76F4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_B5007182176C59429C5331E4556377E6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_EB60FF59B46B5BA89714B10D88DAA977" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_B5007182176C59429C5331E4556377E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_461846BEB9DC5153AFBACD06A92A7A2A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_B5007182176C59429C5331E4556377E6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_461846BEB9DC5153AFBACD06A92A7A2A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_C184F61B5F1658868ACD78B38B66E435" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_461846BEB9DC5153AFBACD06A92A7A2A" xlink:to="loc_us-gaap_InterestRateSwapMember_C184F61B5F1658868ACD78B38B66E435" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_461846BEB9DC5153AFBACD06A92A7A2A" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_4C93458B9A0D5526BDC42A613A36891D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SwaptionMember" xlink:label="loc_us-gaap_SwaptionMember_B4F19EA1612656BA85DF73E3BFFBC141" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_461846BEB9DC5153AFBACD06A92A7A2A" xlink:to="loc_us-gaap_SwaptionMember_B4F19EA1612656BA85DF73E3BFFBC141" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_DD4F1509263F55179ADFD5AA7A06D79B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_461846BEB9DC5153AFBACD06A92A7A2A" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_DD4F1509263F55179ADFD5AA7A06D79B" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_461846BEB9DC5153AFBACD06A92A7A2A" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_69142EDFC6EA5772AA4A7DE991EE9763" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_EB60FF59B46B5BA89714B10D88DAA977" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GrossAmountOfRecognizedAssetsLiabilities" xlink:label="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_BA7123C9437E5F0A8A9C9D4671C43927" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:to="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_BA7123C9437E5F0A8A9C9D4671C43927" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:label="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_9849BC2807C35F67BF8B3282C3D1B1A0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:to="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_9849BC2807C35F67BF8B3282C3D1B1A0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:label="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_87AAE4B1F6945AE68F40CD2553C90AC1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:to="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_87AAE4B1F6945AE68F40CD2553C90AC1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" xlink:label="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_0B2F29292E4C59DD84FDE32E250F72A8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:to="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_0B2F29292E4C59DD84FDE32E250F72A8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" xlink:label="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_6386421A30555ACFAC21173A8E3C2589" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:to="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_6386421A30555ACFAC21173A8E3C2589" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:label="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_C41E02BE02705352A2ADEC22352EAC4C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_595BDA5BAB0A5F338A1C23C9229114C4" xlink:to="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_C41E02BE02705352A2ADEC22352EAC4C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_9BB34F4E0C915D9FA2657110A2AAF656" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_113D4B7B596550459C67E1BE31528C49" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_9BB34F4E0C915D9FA2657110A2AAF656" xlink:to="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_113D4B7B596550459C67E1BE31528C49" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_30C868FC31505CB6BDE3E8DA8C26080B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_113D4B7B596550459C67E1BE31528C49" xlink:to="loc_srt_CounterpartyNameAxis_30C868FC31505CB6BDE3E8DA8C26080B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_18234DFBDCA65A27930FE473FAC2D8E3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_30C868FC31505CB6BDE3E8DA8C26080B" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_18234DFBDCA65A27930FE473FAC2D8E3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FICCMember" xlink:label="loc_agnc_FICCMember_EFAB13992D255ED2B3456F5472B9EB36" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_18234DFBDCA65A27930FE473FAC2D8E3" xlink:to="loc_agnc_FICCMember_EFAB13992D255ED2B3456F5472B9EB36" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_J.P.MorganSecuritiesLLCMember" xlink:label="loc_agnc_J.P.MorganSecuritiesLLCMember_F0B3AC6EDC00588AAB26E57A0A2A34C6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_18234DFBDCA65A27930FE473FAC2D8E3" xlink:to="loc_agnc_J.P.MorganSecuritiesLLCMember_F0B3AC6EDC00588AAB26E57A0A2A34C6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_3AF602F3168F540FB23A8689D79BA3AF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_113D4B7B596550459C67E1BE31528C49" xlink:to="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_3AF602F3168F540FB23A8689D79BA3AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_59B4CF856DDF51A4B5B6A068FD98BDC6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_3AF602F3168F540FB23A8689D79BA3AF" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_59B4CF856DDF51A4B5B6A068FD98BDC6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_94D65B158231576D8AA9755B73C9A53B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_3AF602F3168F540FB23A8689D79BA3AF" xlink:to="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_94D65B158231576D8AA9755B73C9A53B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_68B5A622E60C52BB91776D488C0FD91F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_3AF602F3168F540FB23A8689D79BA3AF" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_68B5A622E60C52BB91776D488C0FD91F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CounterpartyExposureNet" xlink:label="loc_agnc_CounterpartyExposureNet_E4A00985A0F05D6493630D855D43E566" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_3AF602F3168F540FB23A8689D79BA3AF" xlink:to="loc_agnc_CounterpartyExposureNet_E4A00985A0F05D6493630D855D43E566" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_3DE350BBD0705E2C94833D9F9A545EB8" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_3AF602F3168F540FB23A8689D79BA3AF" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_3DE350BBD0705E2C94833D9F9A545EB8" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_D7E64BA4AA7A57CBA78B988BB455E52B" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_B230F1A2D79C5753957B2A13329B73DE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_D7E64BA4AA7A57CBA78B988BB455E52B" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_B230F1A2D79C5753957B2A13329B73DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassAxis" xlink:label="loc_invest_InvestmentSecuritiesClassAxis_A7927524493550A0BA86B1B853F96EF9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_B230F1A2D79C5753957B2A13329B73DE" xlink:to="loc_invest_InvestmentSecuritiesClassAxis_A7927524493550A0BA86B1B853F96EF9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentSecuritiesClassDomain" xlink:label="loc_invest_InvestmentSecuritiesClassDomain_8D7B916BA59E564683999921945BF776" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassAxis_A7927524493550A0BA86B1B853F96EF9" xlink:to="loc_invest_InvestmentSecuritiesClassDomain_8D7B916BA59E564683999921945BF776" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_419331ED5ACC505FB161CC2A920868C0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_8D7B916BA59E564683999921945BF776" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_419331ED5ACC505FB161CC2A920868C0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_18489EDC786C5B7C93C9A1BCE17870E9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_8D7B916BA59E564683999921945BF776" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_18489EDC786C5B7C93C9A1BCE17870E9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NonAgencyMember" xlink:label="loc_agnc_NonAgencyMember_FC58BEE31EA0510785F029D69A315820" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentSecuritiesClassDomain_8D7B916BA59E564683999921945BF776" xlink:to="loc_agnc_NonAgencyMember_FC58BEE31EA0510785F029D69A315820" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_1685F36B2C2153F88CB309F87958F68B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_B230F1A2D79C5753957B2A13329B73DE" xlink:to="loc_us-gaap_InvestmentTypeAxis_1685F36B2C2153F88CB309F87958F68B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_58073E351F5457D199AA8BFFE9CF9FC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_1685F36B2C2153F88CB309F87958F68B" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_58073E351F5457D199AA8BFFE9CF9FC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_E20F6338291B5969A2702BD2E7C7EBD3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_58073E351F5457D199AA8BFFE9CF9FC7" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_E20F6338291B5969A2702BD2E7C7EBD3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeMember" xlink:label="loc_us-gaap_DerivativeMember_6D5D43B419A455229BD84003DBDC68A3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_58073E351F5457D199AA8BFFE9CF9FC7" xlink:to="loc_us-gaap_DerivativeMember_6D5D43B419A455229BD84003DBDC68A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_5AD156DEAB3358BBB25519C37517FEB1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_58073E351F5457D199AA8BFFE9CF9FC7" xlink:to="loc_us-gaap_AgencySecuritiesMember_5AD156DEAB3358BBB25519C37517FEB1" xlink:type="arc" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_58073E351F5457D199AA8BFFE9CF9FC7" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_18489EDC786C5B7C93C9A1BCE17870E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_7B6E1C39F51B5A83A5546D94E4EEF04A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_B230F1A2D79C5753957B2A13329B73DE" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_7B6E1C39F51B5A83A5546D94E4EEF04A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_502246AD1EB652D1819A3E014A9BF2AA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_7B6E1C39F51B5A83A5546D94E4EEF04A" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_502246AD1EB652D1819A3E014A9BF2AA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_A9AE6E4ED6D15E628FC06444CEE34709" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_502246AD1EB652D1819A3E014A9BF2AA" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_A9AE6E4ED6D15E628FC06444CEE34709" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Maturity31To59DaysMember" xlink:label="loc_agnc_Maturity31To59DaysMember_A96D8F6F5C3B5803B5F34C57CCACC6C0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_502246AD1EB652D1819A3E014A9BF2AA" xlink:to="loc_agnc_Maturity31To59DaysMember_A96D8F6F5C3B5803B5F34C57CCACC6C0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Maturity60To90DaysMember" xlink:label="loc_agnc_Maturity60To90DaysMember_3EF9CAA0ADE05FE4832EBB123BF990F5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_502246AD1EB652D1819A3E014A9BF2AA" xlink:to="loc_agnc_Maturity60To90DaysMember_3EF9CAA0ADE05FE4832EBB123BF990F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityOver90DaysMember" xlink:label="loc_us-gaap_MaturityOver90DaysMember_069C3EC42F945F3D8FAE034F72C4313F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_502246AD1EB652D1819A3E014A9BF2AA" xlink:to="loc_us-gaap_MaturityOver90DaysMember_069C3EC42F945F3D8FAE034F72C4313F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_EDAF160A29BA5A85B7407F8BDA096D15" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_502246AD1EB652D1819A3E014A9BF2AA" xlink:to="loc_agnc_A2Daysto1MonthMember_EDAF160A29BA5A85B7407F8BDA096D15" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_1C8A2B28D5F75CD89F7E1CDD814537F8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_B230F1A2D79C5753957B2A13329B73DE" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_1C8A2B28D5F75CD89F7E1CDD814537F8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_C275466AC4825F3DB43320229915CFBF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_1C8A2B28D5F75CD89F7E1CDD814537F8" xlink:to="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_C275466AC4825F3DB43320229915CFBF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_76C24AD20D965811B9456A149597AAF8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_1C8A2B28D5F75CD89F7E1CDD814537F8" xlink:to="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_76C24AD20D965811B9456A149597AAF8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_C2831602D4375A17929FD3F2FA9A84A5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_1C8A2B28D5F75CD89F7E1CDD814537F8" xlink:to="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_C2831602D4375A17929FD3F2FA9A84A5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_8FECAC31DFAF5C69861B3F5D475DC360" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_1C8A2B28D5F75CD89F7E1CDD814537F8" xlink:to="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_8FECAC31DFAF5C69861B3F5D475DC360" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed" xlink:label="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_BE6F3E3642FA5B149584C26D13A6E442" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_1C8A2B28D5F75CD89F7E1CDD814537F8" xlink:to="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_BE6F3E3642FA5B149584C26D13A6E442" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_BEC86C5FE4E8546F89043B6D6F64B640" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock" xlink:label="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_EE28419286D35DB3BDF685B1008BF3B1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_BEC86C5FE4E8546F89043B6D6F64B640" xlink:to="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_EE28419286D35DB3BDF685B1008BF3B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock" xlink:label="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_9FAB94D0527B537789D8001677EF8470" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_BEC86C5FE4E8546F89043B6D6F64B640" xlink:to="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_9FAB94D0527B537789D8001677EF8470" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:label="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_D9BC89952F585E41A10B5B20C568EC14" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_BEC86C5FE4E8546F89043B6D6F64B640" xlink:to="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_D9BC89952F585E41A10B5B20C568EC14" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OffsettingAssetsTableTextBlock" xlink:label="loc_us-gaap_OffsettingAssetsTableTextBlock_DC7E7804616C57E3922F4C8E18144E86" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_BEC86C5FE4E8546F89043B6D6F64B640" xlink:to="loc_us-gaap_OffsettingAssetsTableTextBlock_DC7E7804616C57E3922F4C8E18144E86" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_4933B857B2C4596790333939F4F10BD1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_BEC86C5FE4E8546F89043B6D6F64B640" xlink:to="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_4933B857B2C4596790333939F4F10BD1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_653420C6845D5196B3C59EF997230457" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_653420C6845D5196B3C59EF997230457" xlink:to="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_7143805DDAF15F8B857D58E4578027DE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:to="loc_srt_CounterpartyNameAxis_7143805DDAF15F8B857D58E4578027DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_42FDB18A1D5F5C42BC8EE09F265D1118" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_7143805DDAF15F8B857D58E4578027DE" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_42FDB18A1D5F5C42BC8EE09F265D1118" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FICCMember" xlink:label="loc_agnc_FICCMember_DAF3A15953315469B5268EACB92D565D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_42FDB18A1D5F5C42BC8EE09F265D1118" xlink:to="loc_agnc_FICCMember_DAF3A15953315469B5268EACB92D565D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_4F1A98B2C1FE5F6C806EBEE1AA64C2D5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:to="loc_us-gaap_FinancialInstrumentAxis_4F1A98B2C1FE5F6C806EBEE1AA64C2D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8D975BDC43545B34AFBE1C28E42FDEB3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_4F1A98B2C1FE5F6C806EBEE1AA64C2D5" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8D975BDC43545B34AFBE1C28E42FDEB3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_153D41E2495E52B6BD7F810AC2F117F9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8D975BDC43545B34AFBE1C28E42FDEB3" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_153D41E2495E52B6BD7F810AC2F117F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_3FB4F02CC89752D5AE8C6CBB4D83624C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:to="loc_invest_InvestmentAxis_3FB4F02CC89752D5AE8C6CBB4D83624C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_5D6A783A6136525488E04B30AC01663E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentAxis_3FB4F02CC89752D5AE8C6CBB4D83624C" xlink:to="loc_invest_InvestmentDomain_5D6A783A6136525488E04B30AC01663E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_576DAC64264E50A598F44CBBCDB2050C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentDomain_5D6A783A6136525488E04B30AC01663E" xlink:to="loc_us-gaap_AgencySecuritiesMember_576DAC64264E50A598F44CBBCDB2050C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_48FF1F383F41513A8149D949DB7466CE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:to="loc_us-gaap_DebtInstrumentAxis_48FF1F383F41513A8149D949DB7466CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_A69F89F3433454849D3D4321316B9A75" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_48FF1F383F41513A8149D949DB7466CE" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_A69F89F3433454849D3D4321316B9A75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_371AC1952496542290F757012603C2D8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_A69F89F3433454849D3D4321316B9A75" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_371AC1952496542290F757012603C2D8" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_A69F89F3433454849D3D4321316B9A75" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_153D41E2495E52B6BD7F810AC2F117F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_128A82A003CE53FDB6511864306B27E9" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_128A82A003CE53FDB6511864306B27E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_128A82A003CE53FDB6511864306B27E9" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_82B6945A8C805EE79726E70FF0B71AA8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_us-gaap_MaturityOvernightMember_82B6945A8C805EE79726E70FF0B71AA8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_3DB870F0F7FD568AA899E655455E0A1A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_3DB870F0F7FD568AA899E655455E0A1A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_98826778F162598D98331401DA29ADE1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_ThirtyOneToNinetyMember_98826778F162598D98331401DA29ADE1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_DF3810FA9C285D149E21B5FE18FD378B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A4to6MonthsMember_DF3810FA9C285D149E21B5FE18FD378B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_3763845462B05DFD909EA7622F6F9EAB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A7to9monthsMember_3763845462B05DFD909EA7622F6F9EAB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_D61C636E21F0504AA13451B77B7B92B3" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A10to12MonthsMember_D61C636E21F0504AA13451B77B7B92B3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_151CB12872C35A6EB95DB34172083DF5" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A13to24MonthsMember_151CB12872C35A6EB95DB34172083DF5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_F77E8188836D5248B61195F9B73FF30D" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A25to36monthsMember_F77E8188836D5248B61195F9B73FF30D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_0A500EF24255580E89035A913B3EA031" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A37to48monthsMember_0A500EF24255580E89035A913B3EA031" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_C20CED00FAFB58B29A5699DA268CC950" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A49to60MonthsMember_C20CED00FAFB58B29A5699DA268CC950" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_07587183E22F536BBAC08B748864C79D" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_CC4D69D587FD52CD85ABAAF3CBBD94A6" xlink:to="loc_agnc_A2Daysto1MonthMember_07587183E22F536BBAC08B748864C79D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_959C6B2DB1BD502B9D5FF7E48697D8D3" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_A9A133881D0F5A5DB6FC1212640C5769" xlink:to="loc_us-gaap_StatementLineItems_959C6B2DB1BD502B9D5FF7E48697D8D3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_F18B8BB1877A573480E51ABF743CFC07" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_959C6B2DB1BD502B9D5FF7E48697D8D3" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_F18B8BB1877A573480E51ABF743CFC07" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_1F6A00DD443253FD88BB1B4A8E05C538" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_959C6B2DB1BD502B9D5FF7E48697D8D3" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_1F6A00DD443253FD88BB1B4A8E05C538" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_A0CDDD4C5E0F57AD88C9E0F0C5547773" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_959C6B2DB1BD502B9D5FF7E48697D8D3" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_A0CDDD4C5E0F57AD88C9E0F0C5547773" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_0F81177551935166BCF7010BCB05793A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_959C6B2DB1BD502B9D5FF7E48697D8D3" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_0F81177551935166BCF7010BCB05793A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_9583220EF4985670B41849295097A564" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_959C6B2DB1BD502B9D5FF7E48697D8D3" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_9583220EF4985670B41849295097A564" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_51731673D30C51E295FF70098AF6AC77" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock" xlink:label="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_866961B6DC025A4093BC8E9B068B98AA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_51731673D30C51E295FF70098AF6AC77" xlink:to="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_866961B6DC025A4093BC8E9B068B98AA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_4346065DC7CC575996E659DEE18E373B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShortTermDebtTable" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_4346065DC7CC575996E659DEE18E373B" xlink:to="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_D8128CFBDA3250539483D3F240F5A717" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:to="loc_srt_RangeAxis_D8128CFBDA3250539483D3F240F5A717" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_6D3245BF516D5FB2B31FC3AC19E5DD9E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_D8128CFBDA3250539483D3F240F5A717" xlink:to="loc_srt_RangeMember_6D3245BF516D5FB2B31FC3AC19E5DD9E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_7A2CA2BA45B45086B16818179CC4AF29" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_7A2CA2BA45B45086B16818179CC4AF29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_BC583880364057F4A09549B44DFEA56C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_7A2CA2BA45B45086B16818179CC4AF29" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_BC583880364057F4A09549B44DFEA56C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_148F4435745A5735AC795A74C6ED5172" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_BC583880364057F4A09549B44DFEA56C" xlink:to="loc_agnc_A37to48monthsMember_148F4435745A5735AC795A74C6ED5172" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_CCE821B5CC3E5D00ACB02272D4F5A9C7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:to="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_CCE821B5CC3E5D00ACB02272D4F5A9C7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_207CA44550565A72A9342D9CEF7B75C9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_CCE821B5CC3E5D00ACB02272D4F5A9C7" xlink:to="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_207CA44550565A72A9342D9CEF7B75C9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_301641CA09325B2E89363C8ED9D29255" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_207CA44550565A72A9342D9CEF7B75C9" xlink:to="loc_agnc_A49to60MonthsMember_301641CA09325B2E89363C8ED9D29255" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_207CA44550565A72A9342D9CEF7B75C9" xlink:to="loc_agnc_A37to48monthsMember_148F4435745A5735AC795A74C6ED5172" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_C7162FC8810358AFB31B1C4C3691FE5B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_207CA44550565A72A9342D9CEF7B75C9" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_C7162FC8810358AFB31B1C4C3691FE5B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_4F0BB76D0C835C4C95FC55014181FAFE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_207CA44550565A72A9342D9CEF7B75C9" xlink:to="loc_agnc_ThirtyOneToNinetyMember_4F0BB76D0C835C4C95FC55014181FAFE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_8287FAE43D49513D980A7515C54B377C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_207CA44550565A72A9342D9CEF7B75C9" xlink:to="loc_agnc_A4to6MonthsMember_8287FAE43D49513D980A7515C54B377C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_A1C7D584E15C5B48A625580DA266EA0C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_A1C7D584E15C5B48A625580DA266EA0C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_A35B886289B955F794DFFA85B692AB63" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_A1C7D584E15C5B48A625580DA266EA0C" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_A35B886289B955F794DFFA85B692AB63" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_675DD5C3672B50018E4A21309D220E04" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:to="loc_us-gaap_DebtInstrumentAxis_675DD5C3672B50018E4A21309D220E04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_A2E1BB2D495E540780CCEBA966C9FB92" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_675DD5C3672B50018E4A21309D220E04" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_A2E1BB2D495E540780CCEBA966C9FB92" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtLineItems" xlink:label="loc_us-gaap_ShortTermDebtLineItems_0D2657226AC1578FA7CCE69177231287" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_72AD468950015E3B88C5D4E6AB5E8ACF" xlink:to="loc_us-gaap_ShortTermDebtLineItems_0D2657226AC1578FA7CCE69177231287" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtPercentageBearingFixedInterestRate" xlink:label="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_04B55DF1103D5F859CFB6761D68F4DD5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtLineItems_0D2657226AC1578FA7CCE69177231287" xlink:to="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_04B55DF1103D5F859CFB6761D68F4DD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_90399777E9AC50CFB6190623D41D2062" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtLineItems_0D2657226AC1578FA7CCE69177231287" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_90399777E9AC50CFB6190623D41D2062" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_073EE2F0E24D545583A7132366650F93" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_073EE2F0E24D545583A7132366650F93" xlink:to="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_97117A1732D8595AA65A33356E1BA5CC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:to="loc_srt_CounterpartyNameAxis_97117A1732D8595AA65A33356E1BA5CC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7AF03F21D58E51D68A2D424F4AE6D676" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_97117A1732D8595AA65A33356E1BA5CC" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7AF03F21D58E51D68A2D424F4AE6D676" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_BethesdaSecuritiesMember" xlink:label="loc_agnc_BethesdaSecuritiesMember_9E9E001BBC54592ABF6A80BEF91CA813" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7AF03F21D58E51D68A2D424F4AE6D676" xlink:to="loc_agnc_BethesdaSecuritiesMember_9E9E001BBC54592ABF6A80BEF91CA813" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FICCMember" xlink:label="loc_agnc_FICCMember_181387CCF3B657678442B384CE584057" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7AF03F21D58E51D68A2D424F4AE6D676" xlink:to="loc_agnc_FICCMember_181387CCF3B657678442B384CE584057" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_B4E9B2925C775E09AE7A09633EC5C66A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:to="loc_invest_InvestmentAxis_B4E9B2925C775E09AE7A09633EC5C66A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_C453031D19C459DEA60713F20A4BB491" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentAxis_B4E9B2925C775E09AE7A09633EC5C66A" xlink:to="loc_invest_InvestmentDomain_C453031D19C459DEA60713F20A4BB491" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_3BF8C90FBE7C5311AD78AE6B7EF81D0D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_invest_InvestmentDomain_C453031D19C459DEA60713F20A4BB491" xlink:to="loc_us-gaap_AgencySecuritiesMember_3BF8C90FBE7C5311AD78AE6B7EF81D0D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_81A14155A47057B4B7DB354FBE83B1CD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:to="loc_us-gaap_FinancialInstrumentAxis_81A14155A47057B4B7DB354FBE83B1CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72A812EEC19159F0B6255044D623CE80" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_81A14155A47057B4B7DB354FBE83B1CD" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72A812EEC19159F0B6255044D623CE80" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_7EF080AD0E6B51A0A2AAACAD112C6E27" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72A812EEC19159F0B6255044D623CE80" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_7EF080AD0E6B51A0A2AAACAD112C6E27" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5FC03D6E4E4B525DBD53FAD518664886" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5FC03D6E4E4B525DBD53FAD518664886" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_66901D8B9F8357BEBF58F821F5053E60" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_5FC03D6E4E4B525DBD53FAD518664886" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_66901D8B9F8357BEBF58F821F5053E60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_8BB007127A36561E87BEC539135E4A9F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_66901D8B9F8357BEBF58F821F5053E60" xlink:to="loc_us-gaap_ForwardContractsMember_8BB007127A36561E87BEC539135E4A9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_F8D5B5144BF35008ADE6219BE32918E0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_F8D5B5144BF35008ADE6219BE32918E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_1D3B9AC6689554C2BBDB9AC19E6062AE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_F8D5B5144BF35008ADE6219BE32918E0" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_1D3B9AC6689554C2BBDB9AC19E6062AE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:label="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_0B96FA869ABD5111953EF6DFCC409889" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1D3B9AC6689554C2BBDB9AC19E6062AE" xlink:to="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_0B96FA869ABD5111953EF6DFCC409889" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_5124EF615D1F5D21B56A8122EDA81DF8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1D3B9AC6689554C2BBDB9AC19E6062AE" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_5124EF615D1F5D21B56A8122EDA81DF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_D097C68DA1425EA28E2207EBC1FE447D" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_0A03D4010F525990AD2F2A1A96A9859B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_0A03D4010F525990AD2F2A1A96A9859B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_6425AE1D3DC6559CB9C78D1633851FE4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_6425AE1D3DC6559CB9C78D1633851FE4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_C9F7DC22CC545D8494855005B97FE040" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_DerivativeForwardSettlementValue_C9F7DC22CC545D8494855005B97FE040" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_E81C9CD37F3A5CE4B1AA2A9E7FB6A40D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_E81C9CD37F3A5CE4B1AA2A9E7FB6A40D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PercentageofRepurchaseAgreementFunding" xlink:label="loc_agnc_PercentageofRepurchaseAgreementFunding_1E964B886BA15E27A8B6414AC6492C2E" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_PercentageofRepurchaseAgreementFunding_1E964B886BA15E27A8B6414AC6492C2E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_4C841E410F995CFE86AF6E22D1B61AEA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_4C841E410F995CFE86AF6E22D1B61AEA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageForwardStartDate" xlink:label="loc_agnc_WeightedAverageForwardStartDate_392F4D27C72E5186BD78826F94D45A23" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_WeightedAverageForwardStartDate_392F4D27C72E5186BD78826F94D45A23" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageForwardStartDays" xlink:label="loc_agnc_WeightedAverageForwardStartDays_146E2C6890C553568A30137A1A6D109C" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_WeightedAverageForwardStartDays_146E2C6890C553568A30137A1A6D109C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_1F9FC105A6015FFA933CBB4F7475013B" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_1F9FC105A6015FFA933CBB4F7475013B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_37E4B3EF6B645C1693AEBC73EA4F864F" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_us-gaap_OtherLongTermDebt_37E4B3EF6B645C1693AEBC73EA4F864F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_59E1ACD760A35D4E81BF395B1321775B" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_59E1ACD760A35D4E81BF395B1321775B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SpreadOverLibor" xlink:label="loc_agnc_SpreadOverLibor_D97ABE0F851652BF84420FDD09C5B12F" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_SpreadOverLibor_D97ABE0F851652BF84420FDD09C5B12F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_F55D7059EC325DB79029CF5C1362D36F" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_F55D7059EC325DB79029CF5C1362D36F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageLifeOtherDebt" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_5A8FD4EF2B7159CA9A387FD7413C0F76" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_EEB2ABD950D95628B619609A2E787AEC" xlink:to="loc_agnc_WeightedAverageLifeOtherDebt_5A8FD4EF2B7159CA9A387FD7413C0F76" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_19555784EEDD5D16B46A82CB4A95E335" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_EFAAB4EAA9F9518E9EDDFB618AFB9E92" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_19555784EEDD5D16B46A82CB4A95E335" xlink:to="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_EFAAB4EAA9F9518E9EDDFB618AFB9E92" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_ADC1BD1E918D5A3F8D71B40285A8F435" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_19555784EEDD5D16B46A82CB4A95E335" xlink:to="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_ADC1BD1E918D5A3F8D71B40285A8F435" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_B4F93F51127758C6A6571130926A8F8B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_FD306E9AF3EF5014831B5EB612A1E0C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_B4F93F51127758C6A6571130926A8F8B" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_FD306E9AF3EF5014831B5EB612A1E0C5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_999DCD76F69653988691BF0731586995" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C9E2DD46BB8F51C3905E14AC8243242F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_999DCD76F69653988691BF0731586995" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C9E2DD46BB8F51C3905E14AC8243242F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_823F7B2BFC7550F99A8E76322F97A5A1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C9E2DD46BB8F51C3905E14AC8243242F" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_823F7B2BFC7550F99A8E76322F97A5A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_2EE642260CD85FAABFE523D31BD146A8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_823F7B2BFC7550F99A8E76322F97A5A1" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_2EE642260CD85FAABFE523D31BD146A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_1121D90D14E85FC7ABF834A673E42C3D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_2EE642260CD85FAABFE523D31BD146A8" xlink:to="loc_us-gaap_InterestRateSwapMember_1121D90D14E85FC7ABF834A673E42C3D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_8A40203C1EAC5524A3CDCE90D4A1BB39" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C9E2DD46BB8F51C3905E14AC8243242F" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_8A40203C1EAC5524A3CDCE90D4A1BB39" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_5F288FC4C4FE52B083EAA023538C114D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_8A40203C1EAC5524A3CDCE90D4A1BB39" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_5F288FC4C4FE52B083EAA023538C114D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_107B944471865A40B5ACCE25845F9B2A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_5F288FC4C4FE52B083EAA023538C114D" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_107B944471865A40B5ACCE25845F9B2A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_333E8996B01A5833BF6DB370EB2B4193" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C9E2DD46BB8F51C3905E14AC8243242F" xlink:to="loc_us-gaap_FinancialInstrumentAxis_333E8996B01A5833BF6DB370EB2B4193" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2A88EDC3D25754619D15DA68D6FE214C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_333E8996B01A5833BF6DB370EB2B4193" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2A88EDC3D25754619D15DA68D6FE214C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_D83C45829F2159E1BD08675625EAD5F6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2A88EDC3D25754619D15DA68D6FE214C" xlink:to="loc_us-gaap_AgencySecuritiesMember_D83C45829F2159E1BD08675625EAD5F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C9E2DD46BB8F51C3905E14AC8243242F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_7BFE5FF236ED5F1A8552E906483135D3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_7BFE5FF236ED5F1A8552E906483135D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_D2BA87DAA96C590EAEF7C9AD2843B36E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:to="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_D2BA87DAA96C590EAEF7C9AD2843B36E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_0C72B7FB5EF15D968B81DBB67BC777F3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_0C72B7FB5EF15D968B81DBB67BC777F3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_8BEEB5B7B61053828B756D367FEC75DB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:to="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_8BEEB5B7B61053828B756D367FEC75DB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_8A123954159E54FFB22CA55338E3324D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_8A123954159E54FFB22CA55338E3324D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_F53DDCC7061D5E5EAB1CC704F89BBDE3" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_588A0F8240D2585B950BD9169F7001B1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_F53DDCC7061D5E5EAB1CC704F89BBDE3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_44653D13FF49D9ECD4763C73294C6DA2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7955A4625E708B4E5A2A3C73294C7917" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_44653D13FF49D9ECD4763C73294C6DA2" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7955A4625E708B4E5A2A3C73294C7917" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_E876A32D420F7C9A8E1B3C73294C3BE7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7955A4625E708B4E5A2A3C73294C7917" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_E876A32D420F7C9A8E1B3C73294C3BE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2DE057D8BEFE41D468DA3C73294C4D63" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_E876A32D420F7C9A8E1B3C73294C3BE7" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2DE057D8BEFE41D468DA3C73294C4D63" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CommonStockAtTheMarketSaleAgreementMember" xlink:label="loc_agnc_CommonStockAtTheMarketSaleAgreementMember_872DD5078136DD1BD92C3C7A99EE2850" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2DE057D8BEFE41D468DA3C73294C4D63" xlink:to="loc_agnc_CommonStockAtTheMarketSaleAgreementMember_872DD5078136DD1BD92C3C7A99EE2850" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_A595CE8D42DE0D431F8E3C73294D01AF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7955A4625E708B4E5A2A3C73294C7917" xlink:to="loc_us-gaap_StatementClassOfStockAxis_A595CE8D42DE0D431F8E3C73294D01AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_5E075EB7E494AAB558B93C73294DFBF8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_A595CE8D42DE0D431F8E3C73294D01AF" xlink:to="loc_us-gaap_ClassOfStockDomain_5E075EB7E494AAB558B93C73294DFBF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_C5EFFFB5F7188EED15763C73294EA831" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_5E075EB7E494AAB558B93C73294DFBF8" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_C5EFFFB5F7188EED15763C73294EA831" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_FF8C3015F13EAE654F943C73294EA834" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7955A4625E708B4E5A2A3C73294C7917" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_FF8C3015F13EAE654F943C73294EA834" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_286F025DE70DD82BE2993C73294E5D31" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_FF8C3015F13EAE654F943C73294EA834" xlink:to="loc_us-gaap_EquityComponentDomain_286F025DE70DD82BE2993C73294E5D31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4955D8D2194FD931083D3C73294E5D85" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7955A4625E708B4E5A2A3C73294C7917" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4955D8D2194FD931083D3C73294E5D85" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_DF1BE7257C8637C7D0483C73294FACA1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4955D8D2194FD931083D3C73294E5D85" xlink:to="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_DF1BE7257C8637C7D0483C73294FACA1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_4CF96106ADE84184CB893C73294F4B5F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4955D8D2194FD931083D3C73294E5D85" xlink:to="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_4CF96106ADE84184CB893C73294F4B5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_8EAF3FF43FAD234419733C73294FC7AB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4955D8D2194FD931083D3C73294E5D85" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_8EAF3FF43FAD234419733C73294FC7AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_6221F34445C1B9C0ED593C73294F2438" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4955D8D2194FD931083D3C73294E5D85" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_6221F34445C1B9C0ED593C73294F2438" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_28E257D8E18A2A9012C83C73294F1015" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4955D8D2194FD931083D3C73294E5D85" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_28E257D8E18A2A9012C83C73294F1015" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_DB958DA1AE0ACF24DF193C6A01BAB486" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E9618655914B5BCCE2E3C6A01BAD2FC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_DB958DA1AE0ACF24DF193C6A01BAB486" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E9618655914B5BCCE2E3C6A01BAD2FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_5301DE72DC11EE8238C23C6A01BA0CB0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E9618655914B5BCCE2E3C6A01BAD2FC" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_5301DE72DC11EE8238C23C6A01BA0CB0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_BC599FCE1143515A2E623C6A01BEF7D1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_5301DE72DC11EE8238C23C6A01BA0CB0" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_BC599FCE1143515A2E623C6A01BEF7D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_C9DF961D0260C2A849573C6A01BE0468" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_5301DE72DC11EE8238C23C6A01BA0CB0" xlink:to="loc_us-gaap_PlanNameDomain_C9DF961D0260C2A849573C6A01BE0468" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_DD956284CA66122E5A323C6A01BEB0C2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E9618655914B5BCCE2E3C6A01BAD2FC" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_DD956284CA66122E5A323C6A01BEB0C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_F1C60481FE32AA856EC63C6A01BE298C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_DD956284CA66122E5A323C6A01BEB0C2" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_F1C60481FE32AA856EC63C6A01BE298C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_F30CE1444A6634768DB93C6A01BFF5EF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_F1C60481FE32AA856EC63C6A01BE298C" xlink:to="loc_us-gaap_SubsequentEventMember_F30CE1444A6634768DB93C6A01BFF5EF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_338D49C521F247AC15203C6A01BFA869" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E9618655914B5BCCE2E3C6A01BAD2FC" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_338D49C521F247AC15203C6A01BFA869" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_6D97C17B1C3063E444FA3C6A01BF2C96" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_338D49C521F247AC15203C6A01BFA869" xlink:to="loc_us-gaap_EquityComponentDomain_6D97C17B1C3063E444FA3C6A01BF2C96" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_677871D25C612FC94C963C6A01BF76A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6D97C17B1C3063E444FA3C6A01BF2C96" xlink:to="loc_us-gaap_CommonStockMember_677871D25C612FC94C963C6A01BF76A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E9618655914B5BCCE2E3C6A01BAD2FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_611515D0694106CC0A5C3C6A01C07FB8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_611515D0694106CC0A5C3C6A01C07FB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_B3A86ABB4DF336F1AC593C6A01C0218E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_B3A86ABB4DF336F1AC593C6A01C0218E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:label="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_69F6868BE0139A6A9C3A3C6A01C0A1C5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:to="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_69F6868BE0139A6A9C3A3C6A01C0A1C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_70FEECBBB92EEAD1EEBD3C6A01C13A7C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_70FEECBBB92EEAD1EEBD3C6A01C13A7C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_EC7DB0AD8EB49BB6A6F93C6A01C19775" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_EC7DB0AD8EB49BB6A6F93C6A01C19775" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" xlink:label="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_9EAEE4EB7DF31A16B5663C6A01C1C7F7" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:to="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_9EAEE4EB7DF31A16B5663C6A01C1C7F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_932F8BB26A2628096F943C6A01C19755" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94BA68E86DB41C2E40473C6A01C03532" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_932F8BB26A2628096F943C6A01C19755" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_84EDB49638BD59E8BBE7832062B51C73" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4C4C6EB7441256E79442F4E85D5DC0B9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_84EDB49638BD59E8BBE7832062B51C73" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4C4C6EB7441256E79442F4E85D5DC0B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_7B4A1E41453E5FBCB6689419A996064C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4C4C6EB7441256E79442F4E85D5DC0B9" xlink:to="loc_us-gaap_StatementClassOfStockAxis_7B4A1E41453E5FBCB6689419A996064C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_983145D964845C668409469D8953C6E1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_7B4A1E41453E5FBCB6689419A996064C" xlink:to="loc_us-gaap_ClassOfStockDomain_983145D964845C668409469D8953C6E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredClassBMember" xlink:label="loc_us-gaap_PreferredClassBMember_2CADF34BC28855BF826ED8E731806EC9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_983145D964845C668409469D8953C6E1" xlink:to="loc_us-gaap_PreferredClassBMember_2CADF34BC28855BF826ED8E731806EC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_E578D069DBFC560DA9D625E23C4E4563" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_983145D964845C668409469D8953C6E1" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_E578D069DBFC560DA9D625E23C4E4563" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_F1892B335E885DC2B17F4615802289B9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4C4C6EB7441256E79442F4E85D5DC0B9" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_F1892B335E885DC2B17F4615802289B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_0B6FFBC88240569FAD1EDF0C03BB7034" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_F1892B335E885DC2B17F4615802289B9" xlink:to="loc_us-gaap_EquityComponentDomain_0B6FFBC88240569FAD1EDF0C03BB7034" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C574A9DBDBBF5D96A2D08918AC21BC60" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4C4C6EB7441256E79442F4E85D5DC0B9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C574A9DBDBBF5D96A2D08918AC21BC60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStock" xlink:label="loc_us-gaap_DividendsPreferredStock_6A220ED2A45A5056B1D729409C5BDFDE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C574A9DBDBBF5D96A2D08918AC21BC60" xlink:to="loc_us-gaap_DividendsPreferredStock_6A220ED2A45A5056B1D729409C5BDFDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:label="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_B0CC0EDDCECB5F84A9EAD1B473622AB5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C574A9DBDBBF5D96A2D08918AC21BC60" xlink:to="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_B0CC0EDDCECB5F84A9EAD1B473622AB5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCommonStock" xlink:label="loc_us-gaap_DividendsCommonStock_5A789AC87C3E57DF8F5B97671730A752" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C574A9DBDBBF5D96A2D08918AC21BC60" xlink:to="loc_us-gaap_DividendsCommonStock_5A789AC87C3E57DF8F5B97671730A752" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_F4C57A3AF0DB572D8AB6789495CCBCFA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C574A9DBDBBF5D96A2D08918AC21BC60" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_F4C57A3AF0DB572D8AB6789495CCBCFA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_9D9930DE19BBF451F14F27E88DB2252D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_370E27C855B052A9E09C27E88DB2C487" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_9D9930DE19BBF451F14F27E88DB2252D" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_370E27C855B052A9E09C27E88DB2C487" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_65A31E2C59B4522B553827E88DB21E8C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_370E27C855B052A9E09C27E88DB2C487" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_65A31E2C59B4522B553827E88DB21E8C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2B6FEFF111BCF73A303D27E88DB3E9DB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_65A31E2C59B4522B553827E88DB21E8C" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2B6FEFF111BCF73A303D27E88DB3E9DB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_FollowOnPublicOfferingMember" xlink:label="loc_agnc_FollowOnPublicOfferingMember_F99C4BC820C4B26B848327E88DB3AC2E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2B6FEFF111BCF73A303D27E88DB3E9DB" xlink:to="loc_agnc_FollowOnPublicOfferingMember_F99C4BC820C4B26B848327E88DB3AC2E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_A7266A8810D1C2E715F127E88DB39A90" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_370E27C855B052A9E09C27E88DB2C487" xlink:to="loc_us-gaap_ClassOfStockLineItems_A7266A8810D1C2E715F127E88DB39A90" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_545C3258B2B64D476F2C27E88DB3525F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_A7266A8810D1C2E715F127E88DB39A90" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_545C3258B2B64D476F2C27E88DB3525F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_4B9938596B76E332B7EB27E88DB4430F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_A7266A8810D1C2E715F127E88DB39A90" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_4B9938596B76E332B7EB27E88DB4430F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_7A49763D8641E314E61E27E88DB43B11" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_A7266A8810D1C2E715F127E88DB39A90" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_7A49763D8641E314E61E27E88DB43B11" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityLongTermIncentivePlanDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_5FAC46DF43E650719E6342CE0BB5920E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9C47F42368FB57D69F977419A69AC248" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_5FAC46DF43E650719E6342CE0BB5920E" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9C47F42368FB57D69F977419A69AC248" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_TitleOfIndividualAxis" xlink:label="loc_srt_TitleOfIndividualAxis_79B32E6016215E5C8F0FD44217774F07" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9C47F42368FB57D69F977419A69AC248" xlink:to="loc_srt_TitleOfIndividualAxis_79B32E6016215E5C8F0FD44217774F07" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_6AA3E0C9735457A6B7E07A419594B83E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualAxis_79B32E6016215E5C8F0FD44217774F07" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_6AA3E0C9735457A6B7E07A419594B83E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5BA2B3103F5E58ADB7D4BC024E9CA30C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9C47F42368FB57D69F977419A69AC248" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5BA2B3103F5E58ADB7D4BC024E9CA30C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_8CAB6826F9575E75B8E1EF9969E3B316" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5BA2B3103F5E58ADB7D4BC024E9CA30C" xlink:to="loc_us-gaap_RelatedPartyDomain_8CAB6826F9575E75B8E1EF9969E3B316" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_03401D541E0A5F2887575C328F012DE3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9C47F42368FB57D69F977419A69AC248" xlink:to="loc_us-gaap_AwardTypeAxis_03401D541E0A5F2887575C328F012DE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_056A8E562B4854D7943E7FF1475BF10D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_03401D541E0A5F2887575C328F012DE3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_056A8E562B4854D7943E7FF1475BF10D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7E60FFCF3D3D508EB431E0E9FFAE4AE2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9C47F42368FB57D69F977419A69AC248" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7E60FFCF3D3D508EB431E0E9FFAE4AE2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_44F3C03A2DD1559E842B68F1A93E4EB8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB82A15E80C05D36B3A3E3F4F8D6998D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_44F3C03A2DD1559E842B68F1A93E4EB8" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB82A15E80C05D36B3A3E3F4F8D6998D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_0795F64E54BB59C59749C9E468B89D7C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB82A15E80C05D36B3A3E3F4F8D6998D" xlink:to="loc_us-gaap_VariableRateAxis_0795F64E54BB59C59749C9E468B89D7C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_3FFF16C600885A76A4D8188B656FD95C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_0795F64E54BB59C59749C9E468B89D7C" xlink:to="loc_us-gaap_VariableRateDomain_3FFF16C600885A76A4D8188B656FD95C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis_694CA94410F05706834889E10509E116" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB82A15E80C05D36B3A3E3F4F8D6998D" xlink:to="loc_us-gaap_PreferredUnitsByNameAxis_694CA94410F05706834889E10509E116" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="loc_us-gaap_PreferredUnitsClassDomain_095C9E2BD8565E459D700358D3D4128B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis_694CA94410F05706834889E10509E116" xlink:to="loc_us-gaap_PreferredUnitsClassDomain_095C9E2BD8565E459D700358D3D4128B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DepositaryShareMember" xlink:label="loc_agnc_DepositaryShareMember_31FD5D5FD7D250CB81B856D7A6AB71F4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsClassDomain_095C9E2BD8565E459D700358D3D4128B" xlink:to="loc_agnc_DepositaryShareMember_31FD5D5FD7D250CB81B856D7A6AB71F4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_75D60CA8F22A55D5AE519FFE8B3EF6AF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB82A15E80C05D36B3A3E3F4F8D6998D" xlink:to="loc_us-gaap_StatementClassOfStockAxis_75D60CA8F22A55D5AE519FFE8B3EF6AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_182A88FB1EF652B493604DBABE5E3D91" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_75D60CA8F22A55D5AE519FFE8B3EF6AF" xlink:to="loc_us-gaap_ClassOfStockDomain_182A88FB1EF652B493604DBABE5E3D91" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_4246972FB3BE59A7974516ED3D4BED34" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_182A88FB1EF652B493604DBABE5E3D91" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_4246972FB3BE59A7974516ED3D4BED34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_08667E6AF01D59B7A766BF42A0235BB4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_182A88FB1EF652B493604DBABE5E3D91" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_08667E6AF01D59B7A766BF42A0235BB4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_C9740A0C9EB451AB8EFBE5B61F69CA48" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_182A88FB1EF652B493604DBABE5E3D91" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_C9740A0C9EB451AB8EFBE5B61F69CA48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_FD31BE03381056B2AF3A283AC6BD8DF0" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_182A88FB1EF652B493604DBABE5E3D91" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_FD31BE03381056B2AF3A283AC6BD8DF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB82A15E80C05D36B3A3E3F4F8D6998D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockBValueIssued" xlink:label="loc_agnc_PreferredStockBValueIssued_B42040B7D8FC5A49866B33071BD5BEAD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockBValueIssued_B42040B7D8FC5A49866B33071BD5BEAD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockBLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue_13F638F4977E5F67A1143014DD11ED53" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockBLiquidationPreferenceValue_13F638F4977E5F67A1143014DD11ED53" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockPercentInterestPerShare" xlink:label="loc_agnc_PreferredStockPercentInterestPerShare_F108658E2CAB5AFA97ABB72FBA0F8D70" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockPercentInterestPerShare_F108658E2CAB5AFA97ABB72FBA0F8D70" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_425B3823191E57A58B60BABB1E35FE69" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_425B3823191E57A58B60BABB1E35FE69" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_6E713BD625565D02B0F0511184532CEA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_PreferredStockDividendRatePercentage_6E713BD625565D02B0F0511184532CEA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockDividendPaymentRateVariableRateSpread" xlink:label="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_97D4D683ACE65F2F9A505369F2E81A82" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_97D4D683ACE65F2F9A505369F2E81A82" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreference" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_04B04034702A5077A0C08FAA88C11F5F" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_PreferredStockLiquidationPreference_04B04034702A5077A0C08FAA88C11F5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_AAD3AFAFD3E25AD2B7953C8C7BACD8D4" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_PreferredStockSharesIssued_AAD3AFAFD3E25AD2B7953C8C7BACD8D4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockDValueIssued" xlink:label="loc_agnc_PreferredStockDValueIssued_6BB1A3FA2C8F500B876481325A624A0A" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockDValueIssued_6BB1A3FA2C8F500B876481325A624A0A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockDLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockDLiquidationPreferenceValue_91EF421A6DED5CAF9284A3752C80F86E" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockDLiquidationPreferenceValue_91EF421A6DED5CAF9284A3752C80F86E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockAuthorizedButNotIssued" xlink:label="loc_agnc_PreferredStockAuthorizedButNotIssued_AC91EEC8AFB7520FB7D206BDA53DE7B1" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockAuthorizedButNotIssued_AC91EEC8AFB7520FB7D206BDA53DE7B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_1171B4CEA46A5A21ABF66268EC133C5D" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_1171B4CEA46A5A21ABF66268EC133C5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_16C607919D0C5AF5B94B0B7AF059E8E2" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_16C607919D0C5AF5B94B0B7AF059E8E2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockCValueIssued" xlink:label="loc_agnc_PreferredStockCValueIssued_92DA00187636574699E273DBD8B8BCB2" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockCValueIssued_92DA00187636574699E273DBD8B8BCB2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockCLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue_5BDFDC02B2E650FBBBB305F8BA986632" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_agnc_PreferredStockCLiquidationPreferenceValue_5BDFDC02B2E650FBBBB305F8BA986632" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_34F949B88D9A5C8293DC001758E1164B" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_PreferredStockValue_34F949B88D9A5C8293DC001758E1164B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_D7D7CBA05E8A5CE382B7356D9C9049A5" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07981F53FDC3544C9D599473401AB45E" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_D7D7CBA05E8A5CE382B7356D9C9049A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_372669A746805B7EB78BBD0BAEAD3FD4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_44F3C03A2DD1559E842B68F1A93E4EB8" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_372669A746805B7EB78BBD0BAEAD3FD4" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ScheduleofDividendsDeclaredAbstract" xlink:label="loc_agnc_ScheduleofDividendsDeclaredAbstract_163ADC2E5B5D5E90A7BA39A3B484584D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_BF5A9B93DF78510AA683C71F39B05929" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ScheduleofDividendsDeclaredAbstract_163ADC2E5B5D5E90A7BA39A3B484584D" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_BF5A9B93DF78510AA683C71F39B05929" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_136ACC14D4DC5681832C884D6EF584B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_BF5A9B93DF78510AA683C71F39B05929" xlink:to="loc_us-gaap_StatementClassOfStockAxis_136ACC14D4DC5681832C884D6EF584B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_67EA2EE131725037A58D1E85E254213C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_136ACC14D4DC5681832C884D6EF584B4" xlink:to="loc_us-gaap_ClassOfStockDomain_67EA2EE131725037A58D1E85E254213C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredClassBMember" xlink:label="loc_us-gaap_PreferredClassBMember_E081D64BA87F51328DEA169CDCC226B3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_67EA2EE131725037A58D1E85E254213C" xlink:to="loc_us-gaap_PreferredClassBMember_E081D64BA87F51328DEA169CDCC226B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_C9586ABE5998522A8720C475E89F2A21" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_67EA2EE131725037A58D1E85E254213C" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_C9586ABE5998522A8720C475E89F2A21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_30CF3166CD5A5AFEB20840DF602F6DB0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_BF5A9B93DF78510AA683C71F39B05929" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_30CF3166CD5A5AFEB20840DF602F6DB0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStock" xlink:label="loc_us-gaap_DividendsPreferredStock_43DF07CF50925329AB9134BEAE21C468" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_30CF3166CD5A5AFEB20840DF602F6DB0" xlink:to="loc_us-gaap_DividendsPreferredStock_43DF07CF50925329AB9134BEAE21C468" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:label="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_68999A27F443557B98E6C2996C1E1C29" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_30CF3166CD5A5AFEB20840DF602F6DB0" xlink:to="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_68999A27F443557B98E6C2996C1E1C29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCommonStock" xlink:label="loc_us-gaap_DividendsCommonStock_E5644277CABC58BF934BBC6E6A9BD91C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_30CF3166CD5A5AFEB20840DF602F6DB0" xlink:to="loc_us-gaap_DividendsCommonStock_E5644277CABC58BF934BBC6E6A9BD91C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_9A8E28CDD8F15E4589F80DBD6B7C431A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_30CF3166CD5A5AFEB20840DF602F6DB0" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_9A8E28CDD8F15E4589F80DBD6B7C431A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_B82F43B4AE5358508F3E1F9C639BC533" xlink:type="locator" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockTableTextBlock" xlink:label="loc_agnc_PreferredStockTableTextBlock_A0BF8BA9EBA45B1EAACEC2592FAC06BF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_B82F43B4AE5358508F3E1F9C639BC533" xlink:to="loc_agnc_PreferredStockTableTextBlock_A0BF8BA9EBA45B1EAACEC2592FAC06BF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfStockByClassTextBlock" xlink:label="loc_us-gaap_ScheduleOfStockByClassTextBlock_9D304D0AF3B553B58F7E70FFACFB8BF4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_B82F43B4AE5358508F3E1F9C639BC533" xlink:to="loc_us-gaap_ScheduleOfStockByClassTextBlock_9D304D0AF3B553B58F7E70FFACFB8BF4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsDeclaredTableTextBlock" xlink:label="loc_us-gaap_DividendsDeclaredTableTextBlock_D375467FE5E3526AA8CFFA42372F2AFF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_B82F43B4AE5358508F3E1F9C639BC533" xlink:to="loc_us-gaap_DividendsDeclaredTableTextBlock_D375467FE5E3526AA8CFFA42372F2AFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_342AA666144E59D1B7E5787CAC1C394D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_B82F43B4AE5358508F3E1F9C639BC533" xlink:to="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_342AA666144E59D1B7E5787CAC1C394D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SubsequentEvent" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_ABE97717976D5A90B58592EBE2DF8DF4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_31E48516E6C756A990D94DC43D950056" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_ABE97717976D5A90B58592EBE2DF8DF4" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_31E48516E6C756A990D94DC43D950056" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_9E3CC1C5187CEA6B70AC28B2686113BF" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_CD6B3F512384B89573B828B26861EF3C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_9E3CC1C5187CEA6B70AC28B2686113BF" xlink:to="loc_us-gaap_SubsequentEventTable_CD6B3F512384B89573B828B26861EF3C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis_B63E51853A2A24D4699028D8A279ADE5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_CD6B3F512384B89573B828B26861EF3C" xlink:to="loc_us-gaap_PreferredUnitsByNameAxis_B63E51853A2A24D4699028D8A279ADE5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="loc_us-gaap_PreferredUnitsClassDomain_B9FCB61C590F56A8067F28D8A28A8CE5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis_B63E51853A2A24D4699028D8A279ADE5" xlink:to="loc_us-gaap_PreferredUnitsClassDomain_B9FCB61C590F56A8067F28D8A28A8CE5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DepositaryShareMember" xlink:label="loc_agnc_DepositaryShareMember_5F8053F0DFFAE00E2BFA28D8A2E7A291" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsClassDomain_B9FCB61C590F56A8067F28D8A28A8CE5" xlink:to="loc_agnc_DepositaryShareMember_5F8053F0DFFAE00E2BFA28D8A2E7A291" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_AD733A55A81E89DF703828B26862C45A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_CD6B3F512384B89573B828B26861EF3C" xlink:to="loc_us-gaap_StatementClassOfStockAxis_AD733A55A81E89DF703828B26862C45A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_E64BD17364FDC2D8D4F328B268622A3B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_AD733A55A81E89DF703828B26862C45A" xlink:to="loc_us-gaap_ClassOfStockDomain_E64BD17364FDC2D8D4F328B268622A3B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="loc_us-gaap_SeriesEPreferredStockMember_9602FBCCF202E3E2169F28B268622214" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_E64BD17364FDC2D8D4F328B268622A3B" xlink:to="loc_us-gaap_SeriesEPreferredStockMember_9602FBCCF202E3E2169F28B268622214" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_847818B73F6A914AB87928B26862A6CB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_E64BD17364FDC2D8D4F328B268622A3B" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_847818B73F6A914AB87928B26862A6CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_89BF1DF672ED0821018128B268637BC9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_CD6B3F512384B89573B828B26861EF3C" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_89BF1DF672ED0821018128B268637BC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_66E6E29C0DCC70C9179B28B268639890" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_89BF1DF672ED0821018128B268637BC9" xlink:to="loc_us-gaap_EquityComponentDomain_66E6E29C0DCC70C9179B28B268639890" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_10D4AD5E83327C6114AD28B268632C14" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_66E6E29C0DCC70C9179B28B268639890" xlink:to="loc_us-gaap_CommonStockMember_10D4AD5E83327C6114AD28B268632C14" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_151831DDA4A008772FC528B2686468C3" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_CD6B3F512384B89573B828B26861EF3C" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_151831DDA4A008772FC528B2686468C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_4FB301E217D84527139828B268644BA2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_151831DDA4A008772FC528B2686468C3" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_4FB301E217D84527139828B268644BA2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_D54C15F4E059267D634528B26864CC7E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_4FB301E217D84527139828B268644BA2" xlink:to="loc_us-gaap_SubsequentEventMember_D54C15F4E059267D634528B26864CC7E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_CD6B3F512384B89573B828B26861EF3C" xlink:to="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_622E9829BDA32CA0BD9128D7D98816AC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_PreferredStockDividendRatePercentage_622E9829BDA32CA0BD9128D7D98816AC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockEValueIssued" xlink:label="loc_agnc_PreferredStockEValueIssued_8E66B2042F025B50A11D28B268656316" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_agnc_PreferredStockEValueIssued_8E66B2042F025B50A11D28B268656316" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockDividendPaymentRateVariableRateSpread" xlink:label="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_543CBC1985989B16557528EBF290A4E1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_543CBC1985989B16557528EBF290A4E1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PreferredStockELiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockELiquidationPreferenceValue_C35AB1C0C752DB0E5D2F28B2686568A9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_agnc_PreferredStockELiquidationPreferenceValue_C35AB1C0C752DB0E5D2F28B2686568A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_7B1DF5961B2A4A93232628D8A24750FC" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_PreferredStockSharesIssued_7B1DF5961B2A4A93232628D8A24750FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="loc_us-gaap_DividendsPreferredStockCash_A6D44B1201A49295FC2028B2686549AE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_DividendsPreferredStockCash_A6D44B1201A49295FC2028B2686549AE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendPreferenceOrRestrictions" xlink:label="loc_us-gaap_PreferredStockDividendPreferenceOrRestrictions_6E8DFFFC2B15561077C328B26865A02C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_PreferredStockDividendPreferenceOrRestrictions_6E8DFFFC2B15561077C328B26865A02C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_1BD2378ED9AFE83FE23228B26866B53E" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_1BD2378ED9AFE83FE23228B26866B53E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_1AB43B04686135E9C67328B26866A7BC" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_1AB43B04686135E9C67328B26866A7BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_2E988198E41E58C7A60528B268660B41" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_2E988198E41E58C7A60528B268660B41" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_2FBF83EBA2F9279F803228B268665B56" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_GainLossOnContractTermination_2FBF83EBA2F9279F803228B268665B56" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_1F6A166EB9DE0EEF71DB28B26866386F" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_1F6A166EB9DE0EEF71DB28B26866386F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_BB83001735CDFC94F44E28B268674256" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_BB83001735CDFC94F44E28B268674256" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreference" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_FB0CA545922ADAD255E728D8DF9785A5" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_PreferredStockLiquidationPreference_FB0CA545922ADAD255E728D8DF9785A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_8C31DA699EE471A3E73228D9436569F1" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_9C88A6EDD572A208A2F928B26864BBD2" xlink:to="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_8C31DA699EE471A3E73228D9436569F1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_364434260B175E1A969C13CED7D8CEDA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_7199643645AD548EAF7F62C93D0AE54B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_364434260B175E1A969C13CED7D8CEDA" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_7199643645AD548EAF7F62C93D0AE54B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_39D559E64E7C5427A7EBE5473A3196F3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_A2FAA070626758FB81E66A753DC04E0F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_39D559E64E7C5427A7EBE5473A3196F3" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_A2FAA070626758FB81E66A753DC04E0F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_D7662D3283775B83A3CD996608A7A9CB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_A2FAA070626758FB81E66A753DC04E0F" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_D7662D3283775B83A3CD996608A7A9CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_F79E9F3B6A4E5BC6B75877676B10B14B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_D7662D3283775B83A3CD996608A7A9CB" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_F79E9F3B6A4E5BC6B75877676B10B14B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_31060F4A0B9452F685F308BB7DEA4EDD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_F79E9F3B6A4E5BC6B75877676B10B14B" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_31060F4A0B9452F685F308BB7DEA4EDD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_99F2BF5DC41657058F85CFA2D2C3814F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_A2FAA070626758FB81E66A753DC04E0F" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_99F2BF5DC41657058F85CFA2D2C3814F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_DC10270759195B628D5480DF06325766" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_99F2BF5DC41657058F85CFA2D2C3814F" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_DC10270759195B628D5480DF06325766" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_340443468B585C3F948ACE493D8DA19A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_99F2BF5DC41657058F85CFA2D2C3814F" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_340443468B585C3F948ACE493D8DA19A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_BE3EF03895C15712AC52F0C82090856A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_99F2BF5DC41657058F85CFA2D2C3814F" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_BE3EF03895C15712AC52F0C82090856A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestIncomePolicyTextBlock" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_23B9402A076F55F4A940BFA2583510FE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_99F2BF5DC41657058F85CFA2D2C3814F" xlink:to="loc_agnc_InterestIncomePolicyTextBlock_23B9402A076F55F4A940BFA2583510FE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ManagementAgreementTextBlock" xlink:label="loc_agnc_ManagementAgreementTextBlock_7E3325001E845B4CBB00E8572C0C4158" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_99F2BF5DC41657058F85CFA2D2C3814F" xlink:to="loc_agnc_ManagementAgreementTextBlock_7E3325001E845B4CBB00E8572C0C4158" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_A846847D01F3506A8C3334D36D8CE9C8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_E299430AA34658BF85318A33DE32E9A3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_A846847D01F3506A8C3334D36D8CE9C8" xlink:to="loc_us-gaap_DerivativeTable_E299430AA34658BF85318A33DE32E9A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_8AE26BC908EF5012868F9652178A0A25" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_E299430AA34658BF85318A33DE32E9A3" xlink:to="loc_srt_RangeAxis_8AE26BC908EF5012868F9652178A0A25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_4C905A457A505B5CBE9D717D6EE9E3ED" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_8AE26BC908EF5012868F9652178A0A25" xlink:to="loc_srt_RangeMember_4C905A457A505B5CBE9D717D6EE9E3ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_383C838861A150DA8B2C06FB0E56F167" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_E299430AA34658BF85318A33DE32E9A3" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_383C838861A150DA8B2C06FB0E56F167" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_BB99C311C8E0509AB34D662C186B849A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_383C838861A150DA8B2C06FB0E56F167" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_BB99C311C8E0509AB34D662C186B849A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_7AFE040AFC0D56009B34DC0A80C954BB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_BB99C311C8E0509AB34D662C186B849A" xlink:to="loc_us-gaap_InterestRateSwapMember_7AFE040AFC0D56009B34DC0A80C954BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_300622A769D45DF4B2EEEC55E2A730D3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_E299430AA34658BF85318A33DE32E9A3" xlink:to="loc_us-gaap_DerivativeLineItems_300622A769D45DF4B2EEEC55E2A730D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_0A29D164F7295A38804FBB0C6E6B00E2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_300622A769D45DF4B2EEEC55E2A730D3" xlink:to="loc_us-gaap_GainLossOnContractTermination_0A29D164F7295A38804FBB0C6E6B00E2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_RequiredAnnualDistributionOfTaxableNetIncome" xlink:label="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_DD0D1907F6AC5936983518302A490E9B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_300622A769D45DF4B2EEEC55E2A730D3" xlink:to="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_DD0D1907F6AC5936983518302A490E9B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_B0C9536E0C065D6D876E5016FBC247A5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_300622A769D45DF4B2EEEC55E2A730D3" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_B0C9536E0C065D6D876E5016FBC247A5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_ED23C935345A5C988566D1844741066C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_FC4D67B95E0053FCA473A6EA7D004FE2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_ED23C935345A5C988566D1844741066C" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_FC4D67B95E0053FCA473A6EA7D004FE2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_9A0A016E9C0751D1B0B1B15DD6420BDC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_FC4D67B95E0053FCA473A6EA7D004FE2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_9A0A016E9C0751D1B0B1B15DD6420BDC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_000C352AA12B516EA69BF24E978C57C2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_9A0A016E9C0751D1B0B1B15DD6420BDC" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_000C352AA12B516EA69BF24E978C57C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsAxis" xlink:label="loc_srt_ConsolidationItemsAxis_732192EC128D582E9291CD0F8E34C492" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_FC4D67B95E0053FCA473A6EA7D004FE2" xlink:to="loc_srt_ConsolidationItemsAxis_732192EC128D582E9291CD0F8E34C492" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsDomain" xlink:label="loc_srt_ConsolidationItemsDomain_559E8E3263225BD4BDB17C1A6661549D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsAxis_732192EC128D582E9291CD0F8E34C492" xlink:to="loc_srt_ConsolidationItemsDomain_559E8E3263225BD4BDB17C1A6661549D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_2D4A2BCAB5AE51C8B59A551ACE1EBB3E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_FC4D67B95E0053FCA473A6EA7D004FE2" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_2D4A2BCAB5AE51C8B59A551ACE1EBB3E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_2ED1CB997CA65A4F9DB79347E2BC4E72" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_2D4A2BCAB5AE51C8B59A551ACE1EBB3E" xlink:to="loc_us-gaap_SegmentDomain_2ED1CB997CA65A4F9DB79347E2BC4E72" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_CC2E841E4C9851069BAFF8E544BCD638" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_FC4D67B95E0053FCA473A6EA7D004FE2" xlink:to="loc_srt_RangeAxis_CC2E841E4C9851069BAFF8E544BCD638" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_50ACEEC1264E52E791A10621B3D38176" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_CC2E841E4C9851069BAFF8E544BCD638" xlink:to="loc_srt_RangeMember_50ACEEC1264E52E791A10621B3D38176" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DC51D1CAD9D05100B1E325DE5255246A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_FC4D67B95E0053FCA473A6EA7D004FE2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DC51D1CAD9D05100B1E325DE5255246A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_B041AC4F41685F52B682BAF94949787C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DC51D1CAD9D05100B1E325DE5255246A" xlink:to="loc_us-gaap_Goodwill_B041AC4F41685F52B682BAF94949787C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_380F171F29EE509EA33785CBF5A34941" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DC51D1CAD9D05100B1E325DE5255246A" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_380F171F29EE509EA33785CBF5A34941" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D10960358ECB53CBA85E5F3951742FFA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D10960358ECB53CBA85E5F3951742FFA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_5B2A645B6ED35BE2A72DBCF86515B51F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D10960358ECB53CBA85E5F3951742FFA" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_5B2A645B6ED35BE2A72DBCF86515B51F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_27FBAFACB68E56469EAD840442A91B0E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_5B2A645B6ED35BE2A72DBCF86515B51F" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_27FBAFACB68E56469EAD840442A91B0E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D10960358ECB53CBA85E5F3951742FFA" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_5881023CFD5B5BA2B0C45C613D3EDD1A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_5881023CFD5B5BA2B0C45C613D3EDD1A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_6AEE180F0EB25D2587938A2AFC660EBD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_6AEE180F0EB25D2587938A2AFC660EBD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DB490BEC30D85B718BBC7638626BDFA5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DB490BEC30D85B718BBC7638626BDFA5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock" xlink:label="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_83FDADDB60105136ABA45AD106D20536" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_83FDADDB60105136ABA45AD106D20536" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_79AC062441C55E1B8E4CAA4E03A47376" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_79AC062441C55E1B8E4CAA4E03A47376" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:label="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_3EAAF3BA7AAC5A0185C7DBE1D3CFAD6B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_3EAAF3BA7AAC5A0185C7DBE1D3CFAD6B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_214EC3BD6B5D565AB25B11752CA059FF" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_214EC3BD6B5D565AB25B11752CA059FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_6FA8CC28191151A3A09AAA864467B62B" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_UseOfEstimates_6FA8CC28191151A3A09AAA864467B62B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_040924B388705F23B014EF7395D5DC15" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_040924B388705F23B014EF7395D5DC15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_71404A0C512A5234A094F08DE3DEAEA0" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_71404A0C512A5234A094F08DE3DEAEA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_6171B64308CA54DAA92381678ED82787" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_46471F99FEB65DEF9C3BDE21F14A49F1" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_6171B64308CA54DAA92381678ED82787" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:label="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_E162BE60C52D592486EAFF2A8B856CD9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_E162BE60C52D592486EAFF2A8B856CD9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_D5BE9778265757D09C3AB2B665879991" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_D5BE9778265757D09C3AB2B665879991" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_InterestIncomePolicyTextBlock" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_DAB5DEA71A6950B290561ADD62F5506F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_agnc_InterestIncomePolicyTextBlock_DAB5DEA71A6950B290561ADD62F5506F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAndResaleAgreementsPolicy" xlink:label="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_43167558561C56398109B8D3065F48AC" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_43167558561C56398109B8D3065F48AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_1EEAE3B5C5F85248812A3FA51D627801" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_1EEAE3B5C5F85248812A3FA51D627801" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingencyDisclosures" xlink:label="loc_us-gaap_LossContingencyDisclosures_D8C43C085B4D569098AFE08983198DB0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_us-gaap_LossContingencyDisclosures_D8C43C085B4D569098AFE08983198DB0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_13E4D90FBF505CE38FD7CB746C5DB5ED" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_4A9AAC29701D5D15BCEB0DF3006CA1C9" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_13E4D90FBF505CE38FD7CB746C5DB5ED" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20190930.xsd#agnc_VariableInterestEntitiesAbstract" xlink:label="loc_agnc_VariableInterestEntitiesAbstract_C7BE2C00E6795DD9BCBACCE995CD54CD" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_2FDE8A1BD8835E94A2B5E59CC0F86ABA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_VariableInterestEntitiesAbstract_C7BE2C00E6795DD9BCBACCE995CD54CD" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_2FDE8A1BD8835E94A2B5E59CC0F86ABA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_10D68DF9927952B9A825FCEB6BABE631" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_2FDE8A1BD8835E94A2B5E59CC0F86ABA" xlink:to="loc_us-gaap_DebtInstrumentAxis_10D68DF9927952B9A825FCEB6BABE631" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_C999C0F4E81E5006AD998BA8B76B9058" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_10D68DF9927952B9A825FCEB6BABE631" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_C999C0F4E81E5006AD998BA8B76B9058" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityLineItems" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_927382B398A35EACBDB6DF41684862C1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_2FDE8A1BD8835E94A2B5E59CC0F86ABA" xlink:to="loc_us-gaap_VariableInterestEntityLineItems_927382B398A35EACBDB6DF41684862C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_0807201AB217572CB5B24F8E8A5E8AEB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_927382B398A35EACBDB6DF41684862C1" xlink:to="loc_us-gaap_OtherLongTermDebt_0807201AB217572CB5B24F8E8A5E8AEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_0B5CC78706DD5D779F69CE5D34F1FC89" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_927382B398A35EACBDB6DF41684862C1" xlink:to="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_0B5CC78706DD5D779F69CE5D34F1FC89" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_SpreadOverLibor" xlink:label="loc_agnc_SpreadOverLibor_F2B99543296952459B9EC14555F146EA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_927382B398A35EACBDB6DF41684862C1" xlink:to="loc_agnc_SpreadOverLibor_F2B99543296952459B9EC14555F146EA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_WeightedAverageLifeOtherDebt" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_A77F2FA9C93A5EFEAB31C07254728D80" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_927382B398A35EACBDB6DF41684862C1" xlink:to="loc_agnc_WeightedAverageLifeOtherDebt_A77F2FA9C93A5EFEAB31C07254728D80" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_F63E4A1A08EF411CE4BC3C56A3EDAA2A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_880550F72C607D2593083C56A3ED0358" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_F63E4A1A08EF411CE4BC3C56A3EDAA2A" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_880550F72C607D2593083C56A3ED0358" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_22C3EB0A58F87E1529003C56A3EEA474" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_F63E4A1A08EF411CE4BC3C56A3EDAA2A" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_22C3EB0A58F87E1529003C56A3EEA474" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>
