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    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_805233825DE245D53E0B560F975D8ECE_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_805233825DE245D53E0B560F975D8ECE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents, at Carrying Value</link:label>
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    <link:label id="lab_us-gaap_DerivativeAssets_62E21018CD698D810721560F975D83F3_label_en-US" xlink:label="lab_us-gaap_DerivativeAssets_62E21018CD698D810721560F975D83F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Asset</link:label>
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    <link:label id="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_52E2B80BA769F3618007560F975DF63D_label_en-US" xlink:label="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_52E2B80BA769F3618007560F975DF63D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Receivables from Broker-Dealers and Clearing Organizations</link:label>
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    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_9712A97374EF31AED5B2560F975E80B9_label_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_9712A97374EF31AED5B2560F975E80B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_9712A97374EF31AED5B2560F975E80B9_documentation_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_9712A97374EF31AED5B2560F975E80B9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_CED8BDC5FB7B9FF16AB2560F975F547C" xlink:type="locator" />
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    <link:label id="lab_us-gaap_OtherLongTermDebt_B291B97EFC1CEDA184B9560F975F4AD1_label_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt_B291B97EFC1CEDA184B9560F975F4AD1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Long-term Debt</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_B291B97EFC1CEDA184B9560F975F4AD1" xlink:type="locator" />
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    <link:label id="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_167244929C570D15372D560F975FB884_terseLabel_en-US" xlink:label="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_167244929C570D15372D560F975FB884" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Payable for investment securities purchased</link:label>
    <link:label id="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_167244929C570D15372D560F975FB884_label_en-US" xlink:label="lab_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_167244929C570D15372D560F975FB884" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Payables to Broker-Dealers and Clearing Organizations</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PayablesToBrokerDealersAndClearingOrganizations" xlink:label="loc_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_167244929C570D15372D560F975FB884" xlink:type="locator" />
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    <link:label id="lab_us-gaap_DerivativeLiabilities_BC1DE6DA9EA0D7867A43560F975F5252_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_BC1DE6DA9EA0D7867A43560F975F5252" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Derivative liabilities, at fair value</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilities_BC1DE6DA9EA0D7867A43560F975F5252_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_BC1DE6DA9EA0D7867A43560F975F5252" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Liability</link:label>
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    <link:label id="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_2784E08984B19F63C6AD560F975FC2E6_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_2784E08984B19F63C6AD560F975FC2E6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends payable</link:label>
    <link:label id="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_2784E08984B19F63C6AD560F975FC2E6_label_en-US" xlink:label="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_2784E08984B19F63C6AD560F975FC2E6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends Payable</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_2784E08984B19F63C6AD560F975FC2E6" xlink:type="locator" />
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    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_FA10F5632B6B2342B445560F97603071_verboseLabel_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_FA10F5632B6B2342B445560F97603071" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Obligation to return securities borrowed under reverse repurchase agreements, at fair value</link:label>
    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_FA10F5632B6B2342B445560F97603071_label_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_FA10F5632B6B2342B445560F97603071" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Obligation to Return Securities Borrowed Under Reverse Repurchase Agreements at Fair Value</link:label>
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    <link:loc xlink:href="agnc-20190331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_FA10F5632B6B2342B445560F97603071" xlink:type="locator" />
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    <link:label id="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_0FF80A6BBA118745470D560F9760EBB6_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_0FF80A6BBA118745470D560F9760EBB6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accounts payable and other liabilities</link:label>
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    <link:label id="lab_us-gaap_Liabilities_3F394C346B428EFD9222560F9760974D_totalLabel_en-US" xlink:label="lab_us-gaap_Liabilities_3F394C346B428EFD9222560F9760974D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total liabilities</link:label>
    <link:label id="lab_us-gaap_Liabilities_3F394C346B428EFD9222560F9760974D_label_en-US" xlink:label="lab_us-gaap_Liabilities_3F394C346B428EFD9222560F9760974D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liabilities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_3F394C346B428EFD9222560F9760974D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Liabilities_3F394C346B428EFD9222560F9760974D" xlink:to="lab_us-gaap_Liabilities_3F394C346B428EFD9222560F9760974D" xlink:type="arc" />
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_F1BDAFF91B0DF0B257D4560F9760BB78_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_F1BDAFF91B0DF0B257D4560F9760BB78" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stockholders' equity:</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_F1BDAFF91B0DF0B257D4560F9760BB78_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_F1BDAFF91B0DF0B257D4560F9760BB78" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stockholders' Equity Attributable to Parent [Abstract]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_F1BDAFF91B0DF0B257D4560F9760BB78" xlink:type="locator" />
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    <link:label id="lab_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">7.750% Series B Cumulative Redeemable Preferred Stock (aggregate liquidation preference of $175)</link:label>
    <link:label id="lab_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B_label_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock B, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B_documentation_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Aggregate par or stated value of issued nonredeemable preferred B stock (or preferred stock B redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within stockholders' equity.</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_PreferredStockBValueIssued" xlink:label="loc_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B" xlink:to="lab_agnc_PreferredStockBValueIssued_E80BD3D10901CF3DF8BE560F9760A15B" xlink:type="arc" />
    <link:label id="lab_agnc_PreferredStockCValueIssued_A5E6E11A84B478D9F469560F9761655C_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockCValueIssued_A5E6E11A84B478D9F469560F9761655C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">7.000% Series C Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock (aggregate liquidation preference of $325)</link:label>
    <link:label id="lab_agnc_PreferredStockCValueIssued_A5E6E11A84B478D9F469560F9761655C_label_en-US" xlink:label="lab_agnc_PreferredStockCValueIssued_A5E6E11A84B478D9F469560F9761655C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock C, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockCValueIssued_A5E6E11A84B478D9F469560F9761655C_documentation_en-US" xlink:label="lab_agnc_PreferredStockCValueIssued_A5E6E11A84B478D9F469560F9761655C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Aggregate par or stated value of issued nonredeemable preferred C stock (or preferred stock C redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within stockholders' equity.</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_PreferredStockCValueIssued" xlink:label="loc_agnc_PreferredStockCValueIssued_A5E6E11A84B478D9F469560F9761655C" xlink:type="locator" />
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    <link:label id="lab_agnc_PreferredStockDValueIssued_8467915093B9FE8691B1560F9761AC0C_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockDValueIssued_8467915093B9FE8691B1560F9761AC0C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">6.875% Series D Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock (aggregate liquidation preference of $235)</link:label>
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    <link:label id="lab_us-gaap_CommonStockValue_FFB79B36D814B0C3FFEA560F976104E7_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockValue_FFB79B36D814B0C3FFEA560F976104E7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Common stock - $0.01 par value; 900 and 900 shares authorized, respectively; 536.3 shares issued and outstanding</link:label>
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    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_503A033699E0AC40CC207E4BB2913EB0_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock_503A033699E0AC40CC207E4BB2913EB0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_503A033699E0AC40CC207E4BB2913EB0_label_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock_503A033699E0AC40CC207E4BB2913EB0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
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    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_B970CA1386659677A36E7E4BB2911F06_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_B970CA1386659677A36E7E4BB2911F06" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued interest on pledged securities</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_B970CA1386659677A36E7E4BB2911F06_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_B970CA1386659677A36E7E4BB2911F06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available For Sale Securities Pledged As Collateral Accrued Interest</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_B970CA1386659677A36E7E4BB2911F06_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_B970CA1386659677A36E7E4BB2911F06" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:label="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_B970CA1386659677A36E7E4BB2911F06" xlink:type="locator" />
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    <link:label id="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_16E848C14F05C6C406217E4BB291F648_terseLabel_en-US" xlink:label="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_16E848C14F05C6C406217E4BB291F648" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Fair Value of Securities Pledged and Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_16E848C14F05C6C406217E4BB291F648_label_en-US" xlink:label="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_16E848C14F05C6C406217E4BB291F648" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Total Fair Value of Securities Pledged and Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_16E848C14F05C6C406217E4BB291F648_documentation_en-US" xlink:label="lab_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_16E848C14F05C6C406217E4BB291F648" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Total Fair Value of Securities Pledged and Accrued Interest</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest" xlink:label="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_16E848C14F05C6C406217E4BB291F648" xlink:type="locator" />
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    <link:label id="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_96FEC5FEE8466A9C17687E4BB2911963_terseLabel_en-US" xlink:label="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_96FEC5FEE8466A9C17687E4BB2911963" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Fair Value Of Agency Securities Pledged And Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_96FEC5FEE8466A9C17687E4BB2911963_label_en-US" xlink:label="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_96FEC5FEE8466A9C17687E4BB2911963" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Total Fair Value Of Agency Securities Pledged And Accrued Interest</link:label>
    <link:label id="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_96FEC5FEE8466A9C17687E4BB2911963_documentation_en-US" xlink:label="lab_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_96FEC5FEE8466A9C17687E4BB2911963" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Total Fair Value Of Agency Securities Pledged And Accrued Interest</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" xlink:label="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_96FEC5FEE8466A9C17687E4BB2911963" xlink:type="locator" />
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    <link:label id="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_998A8B8D362D8B9029797989F3420099_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_998A8B8D362D8B9029797989F3420099" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Assets Sold under Agreements to Repurchase [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_998A8B8D362D8B9029797989F3420099_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_998A8B8D362D8B9029797989F3420099" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Assets Sold under Agreements to Repurchase [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_998A8B8D362D8B9029797989F3420099" xlink:type="locator" />
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    <link:label id="lab_invest_InvestmentAxis_BA7876BE40E379440E447989F34448A4_terseLabel_en-US" xlink:label="lab_invest_InvestmentAxis_BA7876BE40E379440E447989F34448A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment [Axis]</link:label>
    <link:label id="lab_invest_InvestmentAxis_BA7876BE40E379440E447989F34448A4_label_en-US" xlink:label="lab_invest_InvestmentAxis_BA7876BE40E379440E447989F34448A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_BA7876BE40E379440E447989F34448A4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentAxis_BA7876BE40E379440E447989F34448A4" xlink:to="lab_invest_InvestmentAxis_BA7876BE40E379440E447989F34448A4" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentDomain_99BC869952A3D1AB4FC37989F344F3DC_terseLabel_en-US" xlink:label="lab_invest_InvestmentDomain_99BC869952A3D1AB4FC37989F344F3DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:label id="lab_invest_InvestmentDomain_99BC869952A3D1AB4FC37989F344F3DC_label_en-US" xlink:label="lab_invest_InvestmentDomain_99BC869952A3D1AB4FC37989F344F3DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_99BC869952A3D1AB4FC37989F344F3DC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentDomain_99BC869952A3D1AB4FC37989F344F3DC" xlink:to="lab_invest_InvestmentDomain_99BC869952A3D1AB4FC37989F344F3DC" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityOvernightMember_814100563B26814AACCA7989F34B5D0D_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_814100563B26814AACCA7989F34B5D0D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityOvernightMember_814100563B26814AACCA7989F34B5D0D_label_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_814100563B26814AACCA7989F34B5D0D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_814100563B26814AACCA7989F34B5D0D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityOvernightMember_814100563B26814AACCA7989F34B5D0D" xlink:to="lab_us-gaap_MaturityOvernightMember_814100563B26814AACCA7989F34B5D0D" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_B05231632DB495B88A757989F34BBB58_verboseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_B05231632DB495B88A757989F34BBB58" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">30 Days or Less [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_B05231632DB495B88A757989F34BBB58" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_B05231632DB495B88A757989F34BBB58" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_B05231632DB495B88A757989F34BBB58" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_C536CD681F8B94B7C9FA7989F34C510B_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_C536CD681F8B94B7C9FA7989F34C510B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">1 to 3 Months</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_C536CD681F8B94B7C9FA7989F34C510B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_C536CD681F8B94B7C9FA7989F34C510B" xlink:to="lab_agnc_ThirtyOneToNinetyMember_C536CD681F8B94B7C9FA7989F34C510B" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_78CC1029CC5CDE9153F87989F34CA584_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_78CC1029CC5CDE9153F87989F34CA584" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3 to 6 Months</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_78CC1029CC5CDE9153F87989F34CA584" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_78CC1029CC5CDE9153F87989F34CA584" xlink:to="lab_agnc_A4to6MonthsMember_78CC1029CC5CDE9153F87989F34CA584" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3" xlink:to="lab_agnc_A7to9monthsMember_930F4357BC10F5D64F137989F34C17C3" xlink:type="arc" />
    <link:label id="lab_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7" xlink:to="lab_agnc_A10to12MonthsMember_FAAB7399B4CE11CC84937989F34CD2E7" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_80C035016924F8C1F3037989F34CF16B_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_80C035016924F8C1F3037989F34CF16B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_80C035016924F8C1F3037989F34CF16B_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_80C035016924F8C1F3037989F34CF16B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_80C035016924F8C1F3037989F34CF16B_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_80C035016924F8C1F3037989F34CF16B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
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    <link:label id="lab_agnc_A25to36monthsMember_5E6699279EC2EA5F7A957989F34C118A_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_5E6699279EC2EA5F7A957989F34C118A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_5E6699279EC2EA5F7A957989F34C118A_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_5E6699279EC2EA5F7A957989F34C118A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_5E6699279EC2EA5F7A957989F34C118A_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_5E6699279EC2EA5F7A957989F34C118A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_5E6699279EC2EA5F7A957989F34C118A" xlink:type="locator" />
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    <link:label id="lab_agnc_A37to48monthsMember_F794564C78820C5EC44E7989F34DB340_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_F794564C78820C5EC44E7989F34DB340" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
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    <link:label id="lab_agnc_A49to60MonthsMember_F74479550F7FF95880177989F34DFF02_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_F74479550F7FF95880177989F34DFF02" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_F74479550F7FF95880177989F34DFF02" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_F74479550F7FF95880177989F34DFF02" xlink:to="lab_agnc_A49to60MonthsMember_F74479550F7FF95880177989F34DFF02" xlink:type="arc" />
    <link:label id="lab_agnc_A2Daysto1MonthMember_A278018D1CFD321211547989F34D9F5B_terseLabel_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_A278018D1CFD321211547989F34D9F5B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_A278018D1CFD321211547989F34D9F5B_label_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_A278018D1CFD321211547989F34D9F5B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">2 Days to 1 Month [Member]</link:label>
    <link:label id="lab_agnc_A2Daysto1MonthMember_A278018D1CFD321211547989F34D9F5B_documentation_en-US" xlink:label="lab_agnc_A2Daysto1MonthMember_A278018D1CFD321211547989F34D9F5B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">U.S. Treasury Repurchase Agreements from 2 Days to 1 Month [Member]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_A278018D1CFD321211547989F34D9F5B" xlink:type="locator" />
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    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_E221FDDB8525AFDEA8B87989F3503304_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_E221FDDB8525AFDEA8B87989F3503304" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_E221FDDB8525AFDEA8B87989F3503304_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_E221FDDB8525AFDEA8B87989F3503304" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate, at Point in Time</link:label>
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    <link:label id="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_45B8666E2242C94129037989F3519028_terseLabel_en-US" xlink:label="lab_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_45B8666E2242C94129037989F3519028" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Obligation to Return Securities Borrowed Under Reverse Repurchase Agreements at Fair Value</link:label>
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    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_F00561968928DF8A8C16548A9BDF2BF6_label_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis_F00561968928DF8A8C16548A9BDF2BF6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_F00561968928DF8A8C16548A9BDF2BF6_documentation_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis_F00561968928DF8A8C16548A9BDF2BF6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_F00561968928DF8A8C16548A9BDF2BF6" xlink:type="locator" />
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    <link:label id="lab_agnc_DerivativeInstrumentsDesignationDomain_F7033257D772CFC2142F548A9BDFA1F9_terseLabel_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationDomain_F7033257D772CFC2142F548A9BDFA1F9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationDomain_F7033257D772CFC2142F548A9BDFA1F9_label_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationDomain_F7033257D772CFC2142F548A9BDFA1F9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments Designation [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationDomain_F7033257D772CFC2142F548A9BDFA1F9_documentation_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationDomain_F7033257D772CFC2142F548A9BDFA1F9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Derivative Instruments Designation [Axis]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_F7033257D772CFC2142F548A9BDFA1F9" xlink:type="locator" />
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    <link:label id="lab_agnc_DerivativesByMaturityAxis_C19B24E0818C90D33E28548A9BE2E2CF_terseLabel_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis_C19B24E0818C90D33E28548A9BE2E2CF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityAxis_C19B24E0818C90D33E28548A9BE2E2CF_label_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis_C19B24E0818C90D33E28548A9BE2E2CF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityAxis_C19B24E0818C90D33E28548A9BE2E2CF_documentation_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis_C19B24E0818C90D33E28548A9BE2E2CF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_C19B24E0818C90D33E28548A9BE2E2CF" xlink:type="locator" />
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    <link:label id="lab_agnc_DerivativesByMaturityDomain_38C77844E34A58D9CD85548A9BE254DC_documentation_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain_38C77844E34A58D9CD85548A9BE254DC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_38C77844E34A58D9CD85548A9BE254DC" xlink:type="locator" />
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    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_0966F52F36ABFC9D702F548A9BE2EE5B_label_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember_0966F52F36ABFC9D702F548A9BE2EE5B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_0966F52F36ABFC9D702F548A9BE2EE5B_documentation_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember_0966F52F36ABFC9D702F548A9BE2EE5B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
    <link:loc xlink:href="agnc-20190331.xsd#agnc_LessThanOrEqualToOneYearMember" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_0966F52F36ABFC9D702F548A9BE2EE5B" xlink:type="locator" />
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