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    <link:label id="lab_agnc_A37to48monthsMember_53D6ADDF6699EDAE47A5016800214BB7_label_en-US" xlink:label="lab_agnc_A37to48monthsMember_53D6ADDF6699EDAE47A5016800214BB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_53D6ADDF6699EDAE47A5016800214BB7_documentation_en-US" xlink:label="lab_agnc_A37to48monthsMember_53D6ADDF6699EDAE47A5016800214BB7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">37 to 48 months [Member]</link:label>
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    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_93F2EF80A225352B38CC016800229172_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_93F2EF80A225352B38CC016800229172" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_93F2EF80A225352B38CC016800229172_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_93F2EF80A225352B38CC016800229172" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_93F2EF80A225352B38CC016800229172" xlink:type="locator" />
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    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_E160D54E7721997E15E2016800222FF4_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_E160D54E7721997E15E2016800222FF4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Domain]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_E160D54E7721997E15E2016800222FF4_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_E160D54E7721997E15E2016800222FF4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">[Domain] for Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_E160D54E7721997E15E2016800222FF4" xlink:type="locator" />
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    <link:label id="lab_agnc_A49to60MonthsMember_185405CC18D6AFCD2F00016800227968_label_en-US" xlink:label="lab_agnc_A49to60MonthsMember_185405CC18D6AFCD2F00016800227968" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_185405CC18D6AFCD2F00016800227968_documentation_en-US" xlink:label="lab_agnc_A49to60MonthsMember_185405CC18D6AFCD2F00016800227968" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_185405CC18D6AFCD2F00016800227968" xlink:type="locator" />
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    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_7A9B3EC50A459125D477016800221FC0_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_7A9B3EC50A459125D477016800221FC0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Less than 30 Days [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_7A9B3EC50A459125D477016800221FC0_label_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_7A9B3EC50A459125D477016800221FC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Less than 30 Days [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_7A9B3EC50A459125D477016800221FC0" xlink:type="locator" />
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    <link:label id="lab_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD_terseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD_label_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD_documentation_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD" xlink:to="lab_agnc_ThirtyOneToNinetyMember_A1D2ED060F5658A1A3960168002330BD" xlink:type="arc" />
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    <link:label id="lab_agnc_A4to6MonthsMember_DD031ABFC48AA72DE48501680023225B_label_en-US" xlink:label="lab_agnc_A4to6MonthsMember_DD031ABFC48AA72DE48501680023225B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_DD031ABFC48AA72DE48501680023225B_documentation_en-US" xlink:label="lab_agnc_A4to6MonthsMember_DD031ABFC48AA72DE48501680023225B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_DD031ABFC48AA72DE48501680023225B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_DD031ABFC48AA72DE48501680023225B" xlink:to="lab_agnc_A4to6MonthsMember_DD031ABFC48AA72DE48501680023225B" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_FDE08BF0F67AC592F7C501680023AB71_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis_FDE08BF0F67AC592F7C501680023AB71" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_FDE08BF0F67AC592F7C501680023AB71_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis_FDE08BF0F67AC592F7C501680023AB71" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_FDE08BF0F67AC592F7C501680023AB71" xlink:type="locator" />
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    <link:label id="lab_us-gaap_ShortTermDebtTypeDomain_E98555B69B74774D73C3016800239AD3_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeDomain_E98555B69B74774D73C3016800239AD3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Domain]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtTypeDomain_E98555B69B74774D73C3016800239AD3_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeDomain_E98555B69B74774D73C3016800239AD3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Type [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_E98555B69B74774D73C3016800239AD3" xlink:type="locator" />
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    <link:label id="lab_us-gaap_DebtInstrumentAxis_2FD10B3EA23983ACA6E9016800230353_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_2FD10B3EA23983ACA6E9016800230353" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentAxis_2FD10B3EA23983ACA6E9016800230353_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_2FD10B3EA23983ACA6E9016800230353" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_2FD10B3EA23983ACA6E9016800230353" xlink:type="locator" />
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    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_D58E9BC59EF538A3180B0168002431FE_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_D58E9BC59EF538A3180B0168002431FE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_D58E9BC59EF538A3180B0168002431FE_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_D58E9BC59EF538A3180B0168002431FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_D58E9BC59EF538A3180B0168002431FE" xlink:type="locator" />
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    <link:label id="lab_us-gaap_ShortTermDebtLineItems_0D024B8FC4B37732054101680024AAC6_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems_0D024B8FC4B37732054101680024AAC6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtLineItems_0D024B8FC4B37732054101680024AAC6_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems_0D024B8FC4B37732054101680024AAC6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtLineItems" xlink:label="loc_us-gaap_ShortTermDebtLineItems_0D024B8FC4B37732054101680024AAC6" xlink:type="locator" />
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    <link:label id="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_7C622EF68A32A5A5724601680024C11D_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_7C622EF68A32A5A5724601680024C11D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Percentage Bearing Fixed Interest Rate</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtPercentageBearingFixedInterestRate" xlink:label="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_7C622EF68A32A5A5724601680024C11D" xlink:type="locator" />
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    <link:label id="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_0174124E06F46419226F01680024F9E0_label_en-US" xlink:label="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_0174124E06F46419226F01680024F9E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Advances from Federal Home Loan Banks</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_0174124E06F46419226F01680024F9E0" xlink:type="locator" />
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    <link:label id="lab_us-gaap_AccountingPoliciesAbstract_60A78871E4CB3E9A6979D5530F805103_label_en-US" xlink:label="lab_us-gaap_AccountingPoliciesAbstract_D647F63CC9435387988169157DF7A039" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounting Policies [Abstract]</link:label>
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    <link:label id="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_C67680ABA0DEBF472F83024BC4C3FDA0_terseLabel_en-US" xlink:label="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_C67680ABA0DEBF472F83024BC4C3FDA0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Principal collections on Agency mortgage-backed securities</link:label>
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    <link:label id="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_AA34864007375C170D6B024BC4C3732A_terseLabel_en-US" xlink:label="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_AA34864007375C170D6B024BC4C3732A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Principal collections on credit risk transfer and non-Agency securities</link:label>
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    <link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_B3997026FC46FBDCC94D024BC4C31ABD_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_B3997026FC46FBDCC94D024BC4C31ABD" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Payments on U.S. Treasury securities</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_B3997026FC46FBDCC94D024BC4C31ABD" xlink:type="locator" />
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    <link:label id="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_D4EBCBA083E5FC6B51C0024BC4C4FBD9_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_D4EBCBA083E5FC6B51C0024BC4C4FBD9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from U.S. Treasury securities</link:label>
    <link:label id="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_D4EBCBA083E5FC6B51C0024BC4C4FBD9_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_D4EBCBA083E5FC6B51C0024BC4C4FBD9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from Sale of Available-for-sale Securities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_D4EBCBA083E5FC6B51C0024BC4C4FBD9" xlink:type="locator" />
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    <link:label id="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_FBF0CD0FD642BE2E8265024BC4C46030_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_FBF0CD0FD642BE2E8265024BC4C46030" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net payments on reverse repurchase agreements</link:label>
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    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_B2778370671010C91770024BC4C4CE89_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_B2778370671010C91770024BC4C4CE89" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Purchase of AGNC Mortgage Management, LLC, net of cash acquired</link:label>
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    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_B77FFE311202E89DAB200168003C63D1" xlink:to="lab_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_B77FFE311202E89DAB200168003C63D1" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentAxis_3E039D436516E4C27F090168003E6F90_terseLabel_en-US" xlink:label="lab_invest_InvestmentAxis_3E039D436516E4C27F090168003E6F90" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment [Axis]</link:label>
    <link:label id="lab_invest_InvestmentAxis_3E039D436516E4C27F090168003E6F90_label_en-US" xlink:label="lab_invest_InvestmentAxis_3E039D436516E4C27F090168003E6F90" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Axis]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_3E039D436516E4C27F090168003E6F90" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentAxis_3E039D436516E4C27F090168003E6F90" xlink:to="lab_invest_InvestmentAxis_3E039D436516E4C27F090168003E6F90" xlink:type="arc" />
    <link:label id="lab_invest_InvestmentDomain_58E86B79E79E4AEE5F720168003EB490_terseLabel_en-US" xlink:label="lab_invest_InvestmentDomain_58E86B79E79E4AEE5F720168003EB490" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:label id="lab_invest_InvestmentDomain_58E86B79E79E4AEE5F720168003EB490_label_en-US" xlink:label="lab_invest_InvestmentDomain_58E86B79E79E4AEE5F720168003EB490" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment [Domain]</link:label>
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_58E86B79E79E4AEE5F720168003EB490" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentDomain_58E86B79E79E4AEE5F720168003EB490" xlink:to="lab_invest_InvestmentDomain_58E86B79E79E4AEE5F720168003EB490" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityOvernightMember_51D5F4A9DA71C5EF53A001680040A656_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_51D5F4A9DA71C5EF53A001680040A656" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityOvernightMember_51D5F4A9DA71C5EF53A001680040A656_label_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_51D5F4A9DA71C5EF53A001680040A656" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_51D5F4A9DA71C5EF53A001680040A656" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityOvernightMember_51D5F4A9DA71C5EF53A001680040A656" xlink:to="lab_us-gaap_MaturityOvernightMember_51D5F4A9DA71C5EF53A001680040A656" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_F2F59CEC39B7449DEEA9016800408425_verboseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_F2F59CEC39B7449DEEA9016800408425" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">30 Days or Less [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_F2F59CEC39B7449DEEA9016800408425" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_F2F59CEC39B7449DEEA9016800408425" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_F2F59CEC39B7449DEEA9016800408425" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_C5093FCC93BB1F7215C4016800404F8D_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_C5093FCC93BB1F7215C4016800404F8D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">1 to 3 Months</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_C5093FCC93BB1F7215C4016800404F8D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_C5093FCC93BB1F7215C4016800404F8D" xlink:to="lab_agnc_ThirtyOneToNinetyMember_C5093FCC93BB1F7215C4016800404F8D" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_C3E1E397BC028C07571F01680040C718_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_C3E1E397BC028C07571F01680040C718" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3 to 6 Months</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_C3E1E397BC028C07571F01680040C718" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_C3E1E397BC028C07571F01680040C718" xlink:to="lab_agnc_A4to6MonthsMember_C3E1E397BC028C07571F01680040C718" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE" xlink:to="lab_agnc_A7to9monthsMember_5F97D425561AF3E0E04A0168004074FE" xlink:type="arc" />
    <link:label id="lab_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518" xlink:to="lab_agnc_A10to12MonthsMember_084C766A9250E4055D4401680041A518" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D" xlink:to="lab_agnc_A13to24MonthsMember_DA638FA1E36A9870780C01680041C81D" xlink:type="arc" />
    <link:label id="lab_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB" xlink:to="lab_agnc_A25to36monthsMember_66389F44B349709B7C210168004179EB" xlink:type="arc" />
    <link:label id="lab_agnc_A37to48monthsMember_E984FC8DD3E2D3E6A9EB01680046FD23_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_E984FC8DD3E2D3E6A9EB01680046FD23" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_E984FC8DD3E2D3E6A9EB01680046FD23" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A37to48monthsMember_E984FC8DD3E2D3E6A9EB01680046FD23" xlink:to="lab_agnc_A37to48monthsMember_E984FC8DD3E2D3E6A9EB01680046FD23" xlink:type="arc" />
    <link:label id="lab_agnc_A49to60MonthsMember_862E836429B7B7FA68AB01680046126E_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_862E836429B7B7FA68AB01680046126E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_862E836429B7B7FA68AB01680046126E" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember_862E836429B7B7FA68AB01680046126E" xlink:to="lab_agnc_A49to60MonthsMember_862E836429B7B7FA68AB01680046126E" xlink:type="arc" />
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_70BE71348E23F86B1A8E016800471D29_verboseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_70BE71348E23F86B1A8E016800471D29" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Repurchase Agreements</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_70BE71348E23F86B1A8E016800471D29" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_70BE71348E23F86B1A8E016800471D29" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_70BE71348E23F86B1A8E016800471D29" xlink:type="arc" />
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_70267FEDC7644703CFA7016800476316_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_70267FEDC7644703CFA7016800476316" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Weighted Average Interest Rate</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_70267FEDC7644703CFA7016800476316_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_70267FEDC7644703CFA7016800476316" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate, at Point in Time</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_70267FEDC7644703CFA7016800476316" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_70267FEDC7644703CFA7016800476316" xlink:to="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_70267FEDC7644703CFA7016800476316" xlink:type="arc" />
    <link:label id="lab_us-gaap_ScheduleOfStockByClassTable_7C907B6EE1163764ACAA0744CA5D31EF_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfStockByClassTable_7C907B6EE1163764ACAA0744CA5D31EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule of Stock by Class [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfStockByClassTable_7C907B6EE1163764ACAA0744CA5D31EF_label_en-US" xlink:label="lab_us-gaap_ScheduleOfStockByClassTable_7C907B6EE1163764ACAA0744CA5D31EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Stock by Class [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_7C907B6EE1163764ACAA0744CA5D31EF" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_7C907B6EE1163764ACAA0744CA5D31EF" xlink:to="lab_us-gaap_ScheduleOfStockByClassTable_7C907B6EE1163764ACAA0744CA5D31EF" xlink:type="arc" />
    <link:label id="lab_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE_terseLabel_en-US" xlink:label="lab_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Follow-On Public Offering [Member]</link:label>
    <link:label id="lab_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE_label_en-US" xlink:label="lab_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Follow-On Public Offering [Member]</link:label>
    <link:label id="lab_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE_documentation_en-US" xlink:label="lab_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Follow-On Public Offering [Member]</link:label>
    <link:loc xlink:href="agnc-20181231.xsd#agnc_FollowOnPublicOfferingMember" xlink:label="loc_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE" xlink:to="lab_agnc_FollowOnPublicOfferingMember_CC82FA0F96FDCE7858E3074CD11E0DFE" xlink:type="arc" />
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