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    <link:label id="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Sale of Debt Securities, Available-for-Sale</link:label>
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    <link:label id="lab_agnc_DerivativesByMaturityDomain_9ae8c561-8fc5-490d-adf9-97357fcede07_terseLabel_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
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    <link:label id="lab_agnc_DerivativesByMaturityDomain_label_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityDomain_documentation_en-US" xlink:label="lab_agnc_DerivativesByMaturityDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives by Maturity [Domain]</link:label>
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    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Type [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
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    <link:label id="lab_ecd_AwardGrantDateFairValue_label_en-US" xlink:label="lab_ecd_AwardGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Grant Date Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardGrantDateFairValue" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardGrantDateFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AwardGrantDateFairValue" xlink:to="lab_ecd_AwardGrantDateFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RepaymentsOfShortTermDebt_1246f2fd-bdbd-4d21-9253-8fd34ffd4523_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfShortTermDebt" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments on repurchase agreements</link:label>
    <link:label id="lab_us-gaap_RepaymentsOfShortTermDebt_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfShortTermDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repayments of Short-Term Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RepaymentsOfShortTermDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfShortTermDebt" xlink:to="lab_us-gaap_RepaymentsOfShortTermDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_23012c31-f74a-4538-a2e2-38cec1ecd73f_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt and Equity Securities, FV-NI [Line Items]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_label_en-US" xlink:label="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt and Equity Securities, FV-NI [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems"/>
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    <link:label id="lab_agnc_MortgageCreditInvestmentFundLimitedPartnership_39c48b8f-9732-454c-92bf-a8ea0a672554_terseLabel_en-US" xlink:label="lab_agnc_MortgageCreditInvestmentFundLimitedPartnership" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage Credit Investment Fund Limited Partnership</link:label>
    <link:label id="lab_agnc_MortgageCreditInvestmentFundLimitedPartnership_label_en-US" xlink:label="lab_agnc_MortgageCreditInvestmentFundLimitedPartnership" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage Credit Investment Fund Limited Partnership</link:label>
    <link:label id="lab_agnc_MortgageCreditInvestmentFundLimitedPartnership_documentation_en-US" xlink:label="lab_agnc_MortgageCreditInvestmentFundLimitedPartnership" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Inerest in a Mortgage Credit Investment Fund Limited Partnership</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_MortgageCreditInvestmentFundLimitedPartnership" xlink:to="lab_agnc_MortgageCreditInvestmentFundLimitedPartnership" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_abdc2679-3bd1-4b4e-b5fa-1b8dc4e2db81_terseLabel_en-US" xlink:label="lab_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Swaps Linked to Overnight Index Swap Rate</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" xlink:href="agnc-20230930.xsd#agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate"/>
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    <link:label id="lab_agnc_WeightedAverageYieldPercentage_4d1e5071-db13-4631-8837-4767b10cffc8_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageYieldPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Yield Percentage</link:label>
    <link:label id="lab_agnc_WeightedAverageYieldPercentage_label_en-US" xlink:label="lab_agnc_WeightedAverageYieldPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Yield Percentage</link:label>
    <link:label id="lab_agnc_WeightedAverageYieldPercentage_documentation_en-US" xlink:label="lab_agnc_WeightedAverageYieldPercentage" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">WeightedAverageYieldPercentage</link:label>
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    <link:label id="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_449dbd48-76e3-4076-b2f0-e4665ef059e3_terseLabel_en-US" xlink:label="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">TBA securities Fifteen Year and Thirty Year Securities [Member]</link:label>
    <link:label id="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_label_en-US" xlink:label="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">TBA securities Fifteen Year and Thirty Year Securities [Member]</link:label>
    <link:label id="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_documentation_en-US" xlink:label="lab_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">TBA securities [Member]</link:label>
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    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_2df74595-a52b-4f82-b484-d5c878e56396_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Available-for-sale Securities Reconciliation</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]</link:label>
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    <link:label id="lab_us-gaap_AdvancesFromFederalHomeLoanBanks_fdd5de9f-0d7b-4f61-9540-8e732da7e381_terseLabel_en-US" xlink:label="lab_us-gaap_AdvancesFromFederalHomeLoanBanks" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Advances from Federal Home Loan Banks</link:label>
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    <link:label id="lab_us-gaap_EarningsPerShareDilutedLineItems_2910a8c7-b279-4a9a-b68f-b59f54ad171d_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDilutedLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDilutedLineItems_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareDilutedLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]</link:label>
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    <link:label id="lab_agnc_SOFRFuturesContractsMember_6310047d-9be8-4a5c-838c-4b0698b1a586_terseLabel_en-US" xlink:label="lab_agnc_SOFRFuturesContractsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">SOFR Futures Contracts</link:label>
    <link:label id="lab_agnc_SOFRFuturesContractsMember_label_en-US" xlink:label="lab_agnc_SOFRFuturesContractsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">SOFR Futures Contracts [Member]</link:label>
    <link:label id="lab_agnc_SOFRFuturesContractsMember_documentation_en-US" xlink:label="lab_agnc_SOFRFuturesContractsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">SOFR Futures Contracts</link:label>
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    <link:label id="lab_ecd_InsiderTradingPoliciesProcLineItems_label_en-US" xlink:label="lab_ecd_InsiderTradingPoliciesProcLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Insider Trading Policies and Procedures [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_InsiderTradingPoliciesProcLineItems" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_InsiderTradingPoliciesProcLineItems"/>
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    <link:label id="lab_ecd_Rule10b51ArrTrmntdFlag_terseLabel_en-US" xlink:label="lab_ecd_Rule10b51ArrTrmntdFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Rule 10b5-1 Arrangement Terminated</link:label>
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    <link:label id="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_5e30d7be-2ebb-4d09-b945-d1e4605a1ba1_verboseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders' Equity</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:to="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_1932b15f-6a7b-4404-8904-842dcaea1fd9_terseLabel_en-US" xlink:label="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Amounts of Recognized Assets</link:label>
    <link:label id="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_label_en-US" xlink:label="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Amount of Recognized Assets (Liabilities)</link:label>
    <link:label id="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities_documentation_en-US" xlink:label="lab_agnc_GrossAmountOfRecognizedAssetsLiabilities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value before effects of master netting arrangements, of a financial asset or liability or other contract and the contract can be net settled by means outside the contract or delivery of an asset or liability.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities" xlink:href="agnc-20230930.xsd#agnc_GrossAmountOfRecognizedAssetsLiabilities"/>
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    <link:label id="lab_us-gaap_VariableInterestEntityLineItems_14e77426-d024-4644-8af0-2bcd8901010a_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity [Line Items]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableInterestEntityLineItems"/>
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    <link:label id="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_70b3c35f-8c03-4c1e-89d2-2f02bc3a348a_negatedTerseLabel_en-US" xlink:label="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instruments</link:label>
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    <link:label id="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_documentation_en-US" xlink:label="lab_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of financial asset or liability or other contract elected not to be offset against an obligation to return collateral or right to receive collateral pledged under a master netting arrangement.</link:label>
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    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_ef46d0bb-7bde-4aac-8ce7-6cb1577aa94d_terseLabel_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_label_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeInstrumentsDesignationAxis_documentation_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments Designation [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis" xlink:href="agnc-20230930.xsd#agnc_DerivativeInstrumentsDesignationAxis"/>
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    <link:label id="lab_agnc_ProceedsFromSaleOfUSTreasurySecurities_25192252-f5cf-44da-9c65-bb5423f108af_terseLabel_en-US" xlink:label="lab_agnc_ProceedsFromSaleOfUSTreasurySecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Sale of U.S. Treasury securities</link:label>
    <link:label id="lab_agnc_ProceedsFromSaleOfUSTreasurySecurities_label_en-US" xlink:label="lab_agnc_ProceedsFromSaleOfUSTreasurySecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Sale of U.S. Treasury securities</link:label>
    <link:label id="lab_agnc_ProceedsFromSaleOfUSTreasurySecurities_documentation_en-US" xlink:label="lab_agnc_ProceedsFromSaleOfUSTreasurySecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The cash inflow associated with the sale of U.S. Treasury securities.</link:label>
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    <link:label id="lab_us-gaap_PreferredStockValue_1e278755-6279-4e0e-9d3d-1cc31c3c7eb7_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock - aggregate liquidation preference of $1,688</link:label>
    <link:label id="lab_us-gaap_PreferredStockValue_723cd5a4-a135-4245-96f5-20603163020e_verboseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Value, Issued</link:label>
    <link:label id="lab_us-gaap_PreferredStockValue_label_en-US" xlink:label="lab_us-gaap_PreferredStockValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Value, Issued</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockValue" xlink:to="lab_us-gaap_PreferredStockValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SubsequentEventTypeDomain_3341724a-26a2-4f2a-b193-58b9aabce86c_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event Type [Domain]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeDomain" xlink:to="lab_us-gaap_SubsequentEventTypeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_edf5458a-c4be-4c29-8e4b-50f0e18ff5df_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss) per common share - diluted</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_f32920ef-1a10-4275-bc80-cfb65f8616f9_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Diluted</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Diluted</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareDiluted" xlink:to="lab_us-gaap_EarningsPerShareDiluted" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfInvestmentsTable_7fef43b1-035b-414b-95a3-9b176c111574_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfInvestmentsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Investments [Table]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfInvestmentsTable"/>
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    <link:loc xlink:type="locator" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet" xlink:href="agnc-20230930.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet"/>
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    <link:label id="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_ef9cfb8d-b0aa-4256-a99e-d869870dbe78_terseLabel_en-US" xlink:label="lab_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Retained Interests in Consolidated VIE's Pledged as Collateral Under Repurchase Agreements</link:label>
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    <link:label id="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_49ad5007-4d9d-4ece-a03f-c966fffde198_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Interest Rate Swaption Agreements Outstanding</link:label>
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    <link:label id="lab_dei_TradingSymbol_8bbd0640-cf06-4b96-aab3-76f9899bcb82_terseLabel_en-US" xlink:label="lab_dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Symbol</link:label>
    <link:label id="lab_dei_TradingSymbol_label_en-US" xlink:label="lab_dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Symbol</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
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    <link:label id="lab_agnc_StockRepurchasedDuringPeriodSettledAfterShares_8337a449-33f7-4665-b7f7-b21ee559aa1d_terseLabel_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodSettledAfterShares" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period Settled After - Shares</link:label>
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    <link:label id="lab_agnc_StockRepurchasedDuringPeriodSettledAfterShares_documentation_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodSettledAfterShares" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of shares that have been repurchase during the period and have not been retired and are not held in treasure but settled after the period. Some state laws may govern the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodSettledAfterShares" xlink:href="agnc-20230930.xsd#agnc_StockRepurchasedDuringPeriodSettledAfterShares"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_StockRepurchasedDuringPeriodSettledAfterShares" xlink:to="lab_agnc_StockRepurchasedDuringPeriodSettledAfterShares" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_9811ba87-c707-412c-95ac-2647b31e39d4_terseLabel_en-US" xlink:label="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Government Agencies Debt Securities [Member]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:to="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPar_17ff4c96-4f3c-4255-90af-ebb159db536b_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPar" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Par value</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPar_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPar" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available For Sale Securities Par</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPar_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPar" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available For Sale Securities Par</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesPar" xlink:href="agnc-20230930.xsd#agnc_AvailableForSaleSecuritiesPar"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesPar" xlink:to="lab_agnc_AvailableForSaleSecuritiesPar" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A10YearMaturityMember_72656d96-df68-413b-854d-9c23ab8bddd3_terseLabel_en-US" xlink:label="lab_agnc_A10YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">10 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A10YearMaturityMember_label_en-US" xlink:label="lab_agnc_A10YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">10 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A10YearMaturityMember_documentation_en-US" xlink:label="lab_agnc_A10YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">10 Year Maturity [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A10YearMaturityMember" xlink:href="agnc-20230930.xsd#agnc_A10YearMaturityMember"/>
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    <link:label id="lab_us-gaap_TradingSecuritiesDebtAmortizedCost_4dc7710b-d4c1-47db-89ce-db6f35b74b42_terseLabel_en-US" xlink:label="lab_us-gaap_TradingSecuritiesDebtAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, Amortized Cost</link:label>
    <link:label id="lab_us-gaap_TradingSecuritiesDebtAmortizedCost_label_en-US" xlink:label="lab_us-gaap_TradingSecuritiesDebtAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, Amortized Cost</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecuritiesDebtAmortizedCost" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TradingSecuritiesDebtAmortizedCost"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecuritiesDebtAmortizedCost" xlink:to="lab_us-gaap_TradingSecuritiesDebtAmortizedCost" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueDisclosuresAbstract_31662381-d98e-4bfb-aeb4-c6ed0fc98707_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Disclosures [Abstract]</link:label>
    <link:label id="lab_us-gaap_FairValueDisclosuresAbstract_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Disclosures [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract" xlink:to="lab_us-gaap_FairValueDisclosuresAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_00ad9eb1-7401-4d0d-97a3-ccfc7c55d149_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">New Accounting Pronouncements or Change in Accounting Principle [Table]</link:label>
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    <link:label id="lab_agnc_DepositaryShareMember_993214db-7630-401b-b34c-504cc5a0f4bf_terseLabel_en-US" xlink:label="lab_agnc_DepositaryShareMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depositary Share [Member]</link:label>
    <link:label id="lab_agnc_DepositaryShareMember_label_en-US" xlink:label="lab_agnc_DepositaryShareMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depositary Share [Member]</link:label>
    <link:label id="lab_agnc_DepositaryShareMember_documentation_en-US" xlink:label="lab_agnc_DepositaryShareMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depositary Share [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DepositaryShareMember" xlink:href="agnc-20230930.xsd#agnc_DepositaryShareMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DepositaryShareMember" xlink:to="lab_agnc_DepositaryShareMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2165cdc0-850b-419f-954d-b3f3f8363148_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and Cash Equivalents [Domain]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:to="lab_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_57c51a19-9cd6-46be-95af-0fe99c63aa38_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders' equity:</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity, Attributable to Parent [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityAbstract" xlink:to="lab_us-gaap_StockholdersEquityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_InterestrateswapreceiverMember_0dcac1c8-5128-4872-890c-78013c76e974_terseLabel_en-US" xlink:label="lab_agnc_InterestrateswapreceiverMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest rate swap - receiver [Member]</link:label>
    <link:label id="lab_agnc_InterestrateswapreceiverMember_label_en-US" xlink:label="lab_agnc_InterestrateswapreceiverMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest rate swap - receiver [Member]</link:label>
    <link:label id="lab_agnc_InterestrateswapreceiverMember_documentation_en-US" xlink:label="lab_agnc_InterestrateswapreceiverMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest rate swap - receiver [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestrateswapreceiverMember" xlink:href="agnc-20230930.xsd#agnc_InterestrateswapreceiverMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestrateswapreceiverMember" xlink:to="lab_agnc_InterestrateswapreceiverMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A20CouponMember_7c619b1f-6c4d-443c-9090-c935e5554113_terseLabel_en-US" xlink:label="lab_agnc_A20CouponMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2.0% Coupon [Member]</link:label>
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    <link:label id="lab_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember_929ec755-36dd-4c78-8883-42545129a0db_terseLabel_en-US" xlink:label="lab_agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases Of TBAs And Forward Settling Agency Securities [Member]</link:label>
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    <link:label id="lab_us-gaap_MaturityOver90DaysMember_594891b8-c110-4830-80ca-d9c6ae4e8946_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOver90DaysMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity over 90 days [Member]</link:label>
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    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_3ac8bb08-676e-4bcc-bb46-b02ade77afbf_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments [Domain]</link:label>
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    <link:label id="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_394da09a-569d-4e64-bcb2-9d1e722c5a45_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Freddie Mac [Member]</link:label>
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    <link:label id="lab_ecd_RecoveryOfErrCompDisclosureLineItems_label_en-US" xlink:label="lab_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Recovery of Erroneously Awarded Compensation Disclosure [Line Items]</link:label>
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    <link:label id="lab_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_dd3652b4-a9be-4784-88db-107a5a85f8b9_terseLabel_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period, Average Repurchase Price (in dollars per share)</link:label>
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    <link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_7c6d9260-3e9f-4f2b-969e-928fb3559148_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Frequency [Axis]</link:label>
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    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_361a3886-8c62-4b92-8378-a11cacbe656d_terseLabel_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Advances by Maturity [Abstract]</link:label>
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    <link:label id="lab_us-gaap_RestrictedStockUnitsRSUMember_dcdf56ca-1287-4632-b3f9-9de6088a8b50_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedStockUnitsRSUMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Stock Units (RSUs) [Member]</link:label>
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    <link:label id="lab_ecd_ForgoneRecoveryDueToViolationOfHomeCountryLawAmt_terseLabel_en-US" xlink:label="lab_ecd_ForgoneRecoveryDueToViolationOfHomeCountryLawAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forgone Recovery due to Violation of Home Country Law, Amount</link:label>
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    <link:label id="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount_8c2147d2-2f7f-480c-a58d-7e4fbd32771f_terseLabel_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading Securities, Unamortized discount</link:label>
    <link:label id="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount_label_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading Securities, Unamortized Discount</link:label>
    <link:label id="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount_documentation_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The amount of unamortized discount on trading securities.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount" xlink:href="agnc-20230930.xsd#agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount" xlink:to="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_b5b1ad28-f073-4d93-ace0-bac8f3bd2783_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates</link:label>
    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_label_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_documentation_en-US" xlink:label="lab_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Borrowings under Repurchase Agreements and Weighted Average Interest Rates [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock"/>
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    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_92b40b68-49d0-43c6-a112-1c5bae684353_verboseLabel_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable under reverse repurchase agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_104da2b4-3477-49fc-9d81-c23abe178235_terseLabel_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_label_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:label id="lab_agnc_ReceivableUnderReverseRepurchaseAgreements_documentation_en-US" xlink:label="lab_agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable Under Reverse Repurchase Agreements</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:href="agnc-20230930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements"/>
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    <link:label id="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_b6e9a90c-e92c-4740-902f-5d0a4048389f_terseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill and other intangible assets, net</link:label>
    <link:label id="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible Assets, Net (Including Goodwill)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
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    <link:label id="lab_agnc_MortgageBackedSecuritiesAmortizedCost_84cbf67e-d2e5-4937-a4ae-ba751a8d629d_terseLabel_en-US" xlink:label="lab_agnc_MortgageBackedSecuritiesAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage Backed Securities Amortized Cost</link:label>
    <link:label id="lab_agnc_MortgageBackedSecuritiesAmortizedCost_label_en-US" xlink:label="lab_agnc_MortgageBackedSecuritiesAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage Backed Securities Amortized Cost</link:label>
    <link:label id="lab_agnc_MortgageBackedSecuritiesAmortizedCost_documentation_en-US" xlink:label="lab_agnc_MortgageBackedSecuritiesAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage Backed Securities Amortized Cost</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_MortgageBackedSecuritiesAmortizedCost" xlink:href="agnc-20230930.xsd#agnc_MortgageBackedSecuritiesAmortizedCost"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_MortgageBackedSecuritiesAmortizedCost" xlink:to="lab_agnc_MortgageBackedSecuritiesAmortizedCost" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_a873683c-2527-4d9a-8650-b1536b47f43d_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consolidation, Variable Interest Entity, Policy</link:label>
    <link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_label_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consolidation, Variable Interest Entity, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConsolidationVariableInterestEntityPolicy"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:to="lab_us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_aa14f699-1484-4b59-9681-ad5e7d6f9870_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Liabilities, Measured on Recurring Basis, Unobservable Input Reconciliation, by Liability Class [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value by Liability Class [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
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    <link:label id="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_41db4243-7e48-47da-a4e3-406b08ffc727_terseLabel_en-US" xlink:label="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">(Loss) gain on derivative instruments and other securities, net</link:label>
    <link:label id="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_label_en-US" xlink:label="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (loss) on derivative instruments and other securities, net</link:label>
    <link:label id="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_documentation_en-US" xlink:label="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (loss) on derivative instruments and other securities, net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:href="agnc-20230930.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:to="lab_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses_03d0c25f-fece-46e6-ba86-d984ea279255_terseLabel_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Gross Unrealized Losses</link:label>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses_label_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Gross Unrealized Losses</link:label>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses_documentation_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The amount of gross unrealized losses on available-for-sale securities.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses" xlink:href="agnc-20230930.xsd#agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses"/>
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    <link:label id="lab_us-gaap_ShortTermDebtLineItems_fc4b9dde-9477-4a18-94df-79a94b5dcbe7_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term Debt [Line Items]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtLineItems_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-Term Debt [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermDebtLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtLineItems" xlink:to="lab_us-gaap_ShortTermDebtLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_TrdArrSecuritiesAggAvailAmt_terseLabel_en-US" xlink:label="lab_ecd_TrdArrSecuritiesAggAvailAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate Available</link:label>
    <link:label id="lab_ecd_TrdArrSecuritiesAggAvailAmt_label_en-US" xlink:label="lab_ecd_TrdArrSecuritiesAggAvailAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Arrangement, Securities Aggregate Available Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrSecuritiesAggAvailAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_TrdArrSecuritiesAggAvailAmt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_TrdArrSecuritiesAggAvailAmt" xlink:to="lab_ecd_TrdArrSecuritiesAggAvailAmt" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_6fd6c498-c264-4fb8-9b1c-b692eca97bb3_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases of Agency mortgage-backed securities</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Mortgage-Backed Securities (MBS), Available-for-Sale</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale"/>
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    <link:label id="lab_ecd_InsiderTrdPoliciesProcNotAdoptedTextBlock_terseLabel_en-US" xlink:label="lab_ecd_InsiderTrdPoliciesProcNotAdoptedTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Insider Trading Policies and Procedures Not Adopted</link:label>
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    <link:label id="lab_agnc_A4.0CouponMember_bab966a2-a883-408b-a082-35469b03bedf_terseLabel_en-US" xlink:label="lab_agnc_A4.0CouponMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.0% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.0CouponMember_label_en-US" xlink:label="lab_agnc_A4.0CouponMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.0% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.0CouponMember_documentation_en-US" xlink:label="lab_agnc_A4.0CouponMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.0% Coupon [Member]</link:label>
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    <link:label id="lab_us-gaap_CollateralizedMortgageObligationsMember_7dd88939-e7c3-4401-afb9-d5798140ee23_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralizedMortgageObligationsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Collateralized Mortgage Obligations [Member]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralizedMortgageObligationsMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollateralizedMortgageObligationsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollateralizedMortgageObligationsMember" xlink:to="lab_us-gaap_CollateralizedMortgageObligationsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt_1adc30a9-9c2a-4d7b-b2ec-9d12e3640b93_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements Extinguished - Extinguishment of Debt</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt_label_en-US" xlink:label="lab_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements Extinguished - Extinguishment of Debt</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The face value of Repurchase Agreements extinguished during the period.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" xlink:href="agnc-20230930.xsd#agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" xlink:to="lab_agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_USgovernmentsecuritiesTableTextBlock_2fb4e722-e23a-431f-979e-791354204740_terseLabel_en-US" xlink:label="lab_agnc_USgovernmentsecuritiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US government securities</link:label>
    <link:label id="lab_agnc_USgovernmentsecuritiesTableTextBlock_label_en-US" xlink:label="lab_agnc_USgovernmentsecuritiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US government securities [Table Text Block]</link:label>
    <link:label id="lab_agnc_USgovernmentsecuritiesTableTextBlock_documentation_en-US" xlink:label="lab_agnc_USgovernmentsecuritiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US government securities [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_USgovernmentsecuritiesTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_USgovernmentsecuritiesTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_USgovernmentsecuritiesTableTextBlock" xlink:to="lab_agnc_USgovernmentsecuritiesTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_3270ee4d-23c4-4408-8f05-6c697e4fd2f7_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:to="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OffsettingLiabilitiesTableTextBlock_ec3cdba2-5568-4472-b8dd-8f14ea88dff2_terseLabel_en-US" xlink:label="lab_us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Offsetting Liabilities</link:label>
    <link:label id="lab_us-gaap_OffsettingLiabilitiesTableTextBlock_label_en-US" xlink:label="lab_us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Offsetting Liabilities [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OffsettingLiabilitiesTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:to="lab_us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare_bc84d97a-8dd8-42e7-87ec-ce7b4ea8fcaa_terseLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Average repurchase price (in dollars per share)</link:label>
    <link:label id="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare_label_en-US" xlink:label="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares Acquired, Average Cost Per Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:to="lab_us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RepurchaseAgreementCounterpartyNameDomain_52bec927-3bc5-4fe2-8d6c-3ea31415b3c7_terseLabel_en-US" xlink:label="lab_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Domain]</link:label>
    <link:label id="lab_srt_RepurchaseAgreementCounterpartyNameDomain_label_en-US" xlink:label="lab_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:to="lab_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_WeightedAverageNumberofSharesOutstanding_de85f903-1193-4304-8257-d63d49db02b2_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageNumberofSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Number of Shares Outstanding</link:label>
    <link:label id="lab_agnc_WeightedAverageNumberofSharesOutstanding_label_en-US" xlink:label="lab_agnc_WeightedAverageNumberofSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Number of Shares Outstanding</link:label>
    <link:label id="lab_agnc_WeightedAverageNumberofSharesOutstanding_documentation_en-US" xlink:label="lab_agnc_WeightedAverageNumberofSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageNumberofSharesOutstanding" xlink:href="agnc-20230930.xsd#agnc_WeightedAverageNumberofSharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_WeightedAverageNumberofSharesOutstanding" xlink:to="lab_agnc_WeightedAverageNumberofSharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentFairValue_a1731a6c-af8c-4111-aa03-14114e097f8a_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Fair Value Disclosure</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentFairValue_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentFairValue" xlink:to="lab_us-gaap_DebtInstrumentFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium_e7ce22cd-ad23-4d87-825d-8bf7fb6e9446_terseLabel_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading Securities, Unamortized Premium</link:label>
    <link:label id="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium_label_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading Securities, Unamortized Premium</link:label>
    <link:label id="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium_documentation_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The amount of unamortized premium on trading securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium" xlink:href="agnc-20230930.xsd#agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium" xlink:to="lab_agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SaleOfStockPricePerShare_563fda5a-49fd-4343-bc15-ee18a1c7d8cf_terseLabel_en-US" xlink:label="lab_us-gaap_SaleOfStockPricePerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sale of Stock, Price Per Share</link:label>
    <link:label id="lab_us-gaap_SaleOfStockPricePerShare_label_en-US" xlink:label="lab_us-gaap_SaleOfStockPricePerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sale of Stock, Price Per Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SaleOfStockPricePerShare" xlink:to="lab_us-gaap_SaleOfStockPricePerShare" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_StkPrcOrTsrEstimationMethodTextBlock_terseLabel_en-US" xlink:label="lab_ecd_StkPrcOrTsrEstimationMethodTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Price or TSR Estimation Method</link:label>
    <link:label id="lab_ecd_StkPrcOrTsrEstimationMethodTextBlock_label_en-US" xlink:label="lab_ecd_StkPrcOrTsrEstimationMethodTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Price or TSR Estimation Method [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_StkPrcOrTsrEstimationMethodTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_StkPrcOrTsrEstimationMethodTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_StkPrcOrTsrEstimationMethodTextBlock" xlink:to="lab_ecd_StkPrcOrTsrEstimationMethodTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_SecurityExchangeName_e64b051f-caca-4273-9783-bd89393ab553_terseLabel_en-US" xlink:label="lab_dei_SecurityExchangeName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Exchange Name</link:label>
    <link:label id="lab_dei_SecurityExchangeName_label_en-US" xlink:label="lab_dei_SecurityExchangeName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Exchange Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_SecurityExchangeName" xlink:to="lab_dei_SecurityExchangeName" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_132f4b5a-c530-4b34-bc3c-0e2d01ec0668_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Redemption Amount</link:label>
    <link:label id="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_label_en-US" xlink:label="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Redeemed or Called During Period, Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:to="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_3e0bd08c-2693-4e8d-9063-b8c415116840_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Payment Arrangement [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-Based Payment Arrangement [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:to="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_b6fa1670-a52f-440b-bb7b-c4937fbe0485_verboseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated other comprehensive income (loss)</link:label>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss), Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredUnitsClassDomain_70012f99-fd27-4ae7-b8fb-696957ab5703_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredUnitsClassDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Units, Class [Domain]</link:label>
    <link:label id="lab_us-gaap_PreferredUnitsClassDomain_label_en-US" xlink:label="lab_us-gaap_PreferredUnitsClassDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Units, Class [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsClassDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredUnitsClassDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredUnitsClassDomain" xlink:to="lab_us-gaap_PreferredUnitsClassDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmployeeStockOptionMember_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeStockOptionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Stock Option</link:label>
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    <link:label id="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_c8dbc1c3-069b-426f-8690-4e0dd8bb8ba3_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Seven Years and Less than or Equal to Ten Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_label_en-US" xlink:label="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Seven Years and Less than or Equal to Ten Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_documentation_en-US" xlink:label="lab_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Seven Years and Less than or Equal to Ten Years [Member]</link:label>
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    <link:label id="lab_us-gaap_RepurchaseAgreementsMember_a51681c0-2a5f-4410-93c9-c24bffc25697_terseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements [Member]</link:label>
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    <link:label id="lab_us-gaap_AntidilutiveSecuritiesNameDomain_a27d824d-8b12-4031-9c89-3d43e1b350bb_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Antidilutive Securities, Name [Domain]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
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    <link:label id="lab_us-gaap_DerivativeTable_label_en-US" xlink:label="lab_us-gaap_DerivativeTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeTable"/>
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    <link:loc xlink:type="locator" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:href="agnc-20230930.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod"/>
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    <link:label id="lab_us-gaap_VariableRateAxis_ff5bc0e3-e543-404e-847c-254b4e111ad8_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate [Axis]</link:label>
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    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_306af144-8fc9-4e8b-806b-1875c69622f8_terseLabel_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_label_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
    <link:label id="lab_agnc_LessThanOrEqualToOneYearMember_documentation_en-US" xlink:label="lab_agnc_LessThanOrEqualToOneYearMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to One Year [Member]</link:label>
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    <link:label id="lab_agnc_CostofSaleofFairValueOptionSecurities_126fc337-e4e4-4660-9bae-45c8cf65c3b5_negatedTerseLabel_en-US" xlink:label="lab_agnc_CostofSaleofFairValueOptionSecurities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost of Sale of Fair Value Option Securities</link:label>
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    <link:label id="lab_agnc_OrdinaryDividendsPerShare_50731509-4de8-4b0f-aff7-5cd606bd374f_terseLabel_en-US" xlink:label="lab_agnc_OrdinaryDividendsPerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ordinary Dividends Per Share</link:label>
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    <link:label id="lab_dei_Security12bTitle_44cd0306-00e6-4422-af0a-5597c49b9e3e_terseLabel_en-US" xlink:label="lab_dei_Security12bTitle" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of 12(b) Security</link:label>
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    <link:label id="lab_agnc_DerivativesByMaturityAxis_label_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
    <link:label id="lab_agnc_DerivativesByMaturityAxis_documentation_en-US" xlink:label="lab_agnc_DerivativesByMaturityAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives By Maturity [Axis]</link:label>
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    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_e59a43d7-2d8d-4c67-b160-9f0186783594_terseLabel_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency Securities Pledged As Collateral Amortized Cost</link:label>
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    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_documentation_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Item represents agency securities pledged as collateral at amortized cost.</link:label>
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    <link:label id="lab_dei_EntityTaxIdentificationNumber_6a3274b1-2464-46b1-b8cc-c8d64527237c_terseLabel_en-US" xlink:label="lab_dei_EntityTaxIdentificationNumber" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Tax Identification Number</link:label>
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    <link:label id="lab_us-gaap_DividendsPreferredStock_b2c2e710-ebbe-4328-9052-9fb28a2eb073_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsPreferredStock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends, Preferred Stock</link:label>
    <link:label id="lab_us-gaap_DividendsPreferredStock_label_en-US" xlink:label="lab_us-gaap_DividendsPreferredStock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends, Preferred Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPreferredStock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsPreferredStock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsPreferredStock" xlink:to="lab_us-gaap_DividendsPreferredStock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_51cc8d9c-4135-40fa-8b47-5f00dc4642e9_terseLabel_en-US" xlink:label="lab_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Derivative Not Designated As Hedging Instruments Receive Rate</link:label>
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    <link:label id="lab_us-gaap_FairValueHedgeLiabilitiesAtFairValue_9c48071c-5e8e-454d-8fea-6c59d0839a6e_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueHedgeLiabilitiesAtFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Hedge Liabilities</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgeLiabilitiesAtFairValue" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueHedgeLiabilitiesAtFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueHedgeLiabilitiesAtFairValue" xlink:to="lab_us-gaap_FairValueHedgeLiabilitiesAtFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RangeAxis_59ce39f3-1107-4e5b-b98d-e65e537e0c8c_terseLabel_en-US" xlink:label="lab_srt_RangeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statistical Measurement [Axis]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RangeAxis" xlink:to="lab_srt_RangeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BalanceSheetLocationDomain_60c9ee7a-1f07-4da2-b8c4-e5995c130e92_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance Sheet Location [Domain]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BalanceSheetLocationDomain" xlink:to="lab_us-gaap_BalanceSheetLocationDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityInteractiveDataCurrent_70721752-6811-411d-b11d-2d2ec67b51c6_terseLabel_en-US" xlink:label="lab_dei_EntityInteractiveDataCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Interactive Data Current</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityInteractiveDataCurrent" xlink:to="lab_dei_EntityInteractiveDataCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_d3c54cf4-49a9-4372-9c18-fd2cd0219128_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill and Intangible Assets, Policy [Policy Text Block]</link:label>
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    <link:label id="lab_dei_EntityWellKnownSeasonedIssuer_a0e62ca6-d351-42c3-86bc-5bf4014b601e_terseLabel_en-US" xlink:label="lab_dei_EntityWellKnownSeasonedIssuer" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Well-known Seasoned Issuer</link:label>
    <link:label id="lab_dei_EntityWellKnownSeasonedIssuer_label_en-US" xlink:label="lab_dei_EntityWellKnownSeasonedIssuer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Well-known Seasoned Issuer</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityWellKnownSeasonedIssuer" xlink:to="lab_dei_EntityWellKnownSeasonedIssuer" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockFValueIssued_799c5c7f-1f23-441d-9e3c-9f803efc3ab6_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockFValueIssued" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock F, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockFValueIssued_label_en-US" xlink:label="lab_agnc_PreferredStockFValueIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock F, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockFValueIssued_documentation_en-US" xlink:label="lab_agnc_PreferredStockFValueIssued" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate par or stated value of issued nonredeemable preferred F stock (or preferred stock F redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within the stockholders' equity.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockFValueIssued" xlink:href="agnc-20230930.xsd#agnc_PreferredStockFValueIssued"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockFValueIssued" xlink:to="lab_agnc_PreferredStockFValueIssued" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_06edc4dd-38c3-4135-9d96-b903b06be63e_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net proceeds from derivative instruments</link:label>
    <link:label id="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_label_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for (Proceeds from) Derivative Instrument, Investing Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities" xlink:to="lab_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_f36d523a-e5cf-492a-8c17-fb7776965cdd_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Capital Shares Reserved for Future Issuance</link:label>
    <link:label id="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_label_en-US" xlink:label="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Capital Shares Reserved for Future Issuance</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:to="lab_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_31adb39b-fa4d-454b-9407-5725c5b274b1_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GainLossOnContractTermination_2c3fce05-4df3-46f9-a2c6-b018568fcbf0_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnContractTermination" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (Loss) on Contract Termination</link:label>
    <link:label id="lab_us-gaap_GainLossOnContractTermination_label_en-US" xlink:label="lab_us-gaap_GainLossOnContractTermination" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (Loss) on Contract Termination</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnContractTermination" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnContractTermination"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnContractTermination" xlink:to="lab_us-gaap_GainLossOnContractTermination" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredStockDividendRatePerDollarAmount_e5025b3b-3d02-42a3-8df4-9223db08652a_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividend Rate, Per-Dollar-Amount</link:label>
    <link:label id="lab_us-gaap_PreferredStockDividendRatePerDollarAmount_label_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividend Rate, Per-Dollar-Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockDividendRatePerDollarAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:to="lab_us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_8fb6d728-fd82-43d1-84f8-2e078c4eb968_terseLabel_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading and Available-for-sale, Amortized Cost Basis</link:label>
    <link:label id="lab_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_label_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading and Available-for-sale, Amortized Cost Basis</link:label>
    <link:label id="lab_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_documentation_en-US" xlink:label="lab_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount of investment in debt security measured at fair value with change in fair value recognized in net income (trading) and investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale) at cost.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:href="agnc-20230930.xsd#agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:to="lab_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_MeasureAxis_terseLabel_en-US" xlink:label="lab_ecd_MeasureAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measure:</link:label>
    <link:label id="lab_ecd_MeasureAxis_label_en-US" xlink:label="lab_ecd_MeasureAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measure [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_MeasureAxis" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_MeasureAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_MeasureAxis" xlink:to="lab_ecd_MeasureAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_OutstandingRecoveryIndName_terseLabel_en-US" xlink:label="lab_ecd_OutstandingRecoveryIndName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name</link:label>
    <link:label id="lab_ecd_OutstandingRecoveryIndName_label_en-US" xlink:label="lab_ecd_OutstandingRecoveryIndName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outstanding Recovery, Individual Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_OutstandingRecoveryIndName" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_OutstandingRecoveryIndName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_OutstandingRecoveryIndName" xlink:to="lab_ecd_OutstandingRecoveryIndName" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityIncorporationStateCountryCode_f8c8ca51-393b-4f77-b9aa-b39e60b4d1b2_terseLabel_en-US" xlink:label="lab_dei_EntityIncorporationStateCountryCode" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Incorporation, State or Country Code</link:label>
    <link:label id="lab_dei_EntityIncorporationStateCountryCode_label_en-US" xlink:label="lab_dei_EntityIncorporationStateCountryCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Incorporation, State or Country Code</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityIncorporationStateCountryCode" xlink:to="lab_dei_EntityIncorporationStateCountryCode" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_ced2eca4-750b-4f69-b48b-bdd68d3e8fda_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill and Intangible Assets, Goodwill, Policy</link:label>
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherLongTermDebt_8bee592b-f9cd-4c58-ae27-c0e42e4fc66c_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt of consolidated variable interest entities, at fair value</link:label>
    <link:label id="lab_us-gaap_OtherLongTermDebt_caa4a3fc-2a6e-4cc4-9fcf-d5e5c887022e_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Long-term Debt</link:label>
    <link:label id="lab_us-gaap_OtherLongTermDebt_b85e15a1-6a4d-4116-82bb-a8620641086c_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt, at fair value</link:label>
    <link:label id="lab_us-gaap_OtherLongTermDebt_6af8ddf0-792a-44bf-80f7-79a953506273_negatedLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt of consolidated variable interest entities, at fair value</link:label>
    <link:label id="lab_us-gaap_OtherLongTermDebt_label_en-US" xlink:label="lab_us-gaap_OtherLongTermDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Long-Term Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLongTermDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLongTermDebt" xlink:to="lab_us-gaap_OtherLongTermDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_CounterpartyNameAxis_e958ea1e-c761-4c37-a2d7-246c9bde31ad_terseLabel_en-US" xlink:label="lab_srt_CounterpartyNameAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Axis]</link:label>
    <link:label id="lab_srt_CounterpartyNameAxis_label_en-US" xlink:label="lab_srt_CounterpartyNameAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_CounterpartyNameAxis" xlink:to="lab_srt_CounterpartyNameAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativesPolicyTextBlock_47d6bc39-e900-4d17-82b5-607e22783670_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments</link:label>
    <link:label id="lab_us-gaap_DerivativesPolicyTextBlock_c3c800f0-8e48-42e4-afff-5226119142ee_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives, Policy [Policy Text Block]</link:label>
    <link:label id="lab_us-gaap_DerivativesPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativesPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesPolicyTextBlock" xlink:to="lab_us-gaap_DerivativesPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CreditDefaultSwapMember_929134de-5317-4b0f-ba2a-6e1f2d774d8d_terseLabel_en-US" xlink:label="lab_us-gaap_CreditDefaultSwapMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Default Swap</link:label>
    <link:label id="lab_us-gaap_CreditDefaultSwapMember_label_en-US" xlink:label="lab_us-gaap_CreditDefaultSwapMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Default Swap [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditDefaultSwapMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditDefaultSwapMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditDefaultSwapMember" xlink:to="lab_us-gaap_CreditDefaultSwapMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_7e11a1d3-091d-4c29-a827-c536cd69fe19_terseLabel_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_label_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
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    <link:label id="lab_ecd_OutstandingAggtErrCompAmt_terseLabel_en-US" xlink:label="lab_ecd_OutstandingAggtErrCompAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outstanding Aggregate Erroneous Compensation Amount</link:label>
    <link:label id="lab_ecd_OutstandingAggtErrCompAmt_label_en-US" xlink:label="lab_ecd_OutstandingAggtErrCompAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outstanding Aggregate Erroneous Compensation Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_OutstandingAggtErrCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_OutstandingAggtErrCompAmt"/>
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    <link:label id="lab_agnc_A7YearsMaturityMember_47d4c8de-b5b4-4968-bdee-84950c24a10d_terseLabel_en-US" xlink:label="lab_agnc_A7YearsMaturityMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">7 Years Maturity [Member]</link:label>
    <link:label id="lab_agnc_A7YearsMaturityMember_label_en-US" xlink:label="lab_agnc_A7YearsMaturityMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">7 Years Maturity [Member]</link:label>
    <link:label id="lab_agnc_A7YearsMaturityMember_documentation_en-US" xlink:label="lab_agnc_A7YearsMaturityMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">7 Years Maturity [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A7YearsMaturityMember" xlink:href="agnc-20230930.xsd#agnc_A7YearsMaturityMember"/>
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    <link:label id="lab_us-gaap_SeriesBPreferredStockMember_833ba803-8f18-4e4e-b02a-768f9066f4e2_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesBPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series B Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_SeriesBPreferredStockMember_label_en-US" xlink:label="lab_us-gaap_SeriesBPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series B Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesBPreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesBPreferredStockMember" xlink:to="lab_us-gaap_SeriesBPreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_Liabilities_42af2c97-1f2a-4c61-ae5c-10806fc429c2_totalLabel_en-US" xlink:label="lab_us-gaap_Liabilities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total liabilities</link:label>
    <link:label id="lab_us-gaap_Liabilities_label_en-US" xlink:label="lab_us-gaap_Liabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Liabilities" xlink:to="lab_us-gaap_Liabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_86984659-d739-4722-aabf-32b1e4a3932b_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Unrealized Gain (Loss) on Swaps</link:label>
    <link:label id="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_23b5eaf7-ce6d-403a-b738-8a3b06deab7e_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2022</link:label>
    <link:label id="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_label_en-US" xlink:label="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Gain (Loss) on Discontinuation of Interest Rate Fair Value Hedge</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:to="lab_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_d360c811-c9fd-4f61-80e2-fd0aa85ba338_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Unrealized Loss Position</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Unrealized Loss Position</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:to="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_ec027f18-89cd-432a-a73a-715ba82a0627_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Frequency [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Frequency [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain" xlink:to="lab_us-gaap_FairValueMeasurementFrequencyDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_TitleOfIndividualAxis_3ef47db9-30af-49ca-a621-372705db365f_terseLabel_en-US" xlink:label="lab_srt_TitleOfIndividualAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of Individual [Axis]</link:label>
    <link:label id="lab_srt_TitleOfIndividualAxis_label_en-US" xlink:label="lab_srt_TitleOfIndividualAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of Individual [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_TitleOfIndividualAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_TitleOfIndividualAxis" xlink:to="lab_srt_TitleOfIndividualAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredStockDividendsPerShareDeclared_9e50c75d-2dab-4b84-9964-50035554654f_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendsPerShareDeclared" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividend Rate, Per-Dollar-Amount</link:label>
    <link:label id="lab_us-gaap_PreferredStockDividendsPerShareDeclared_label_en-US" xlink:label="lab_us-gaap_PreferredStockDividendsPerShareDeclared" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividends Per Share, Declared</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsPerShareDeclared" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockDividendsPerShareDeclared"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendsPerShareDeclared" xlink:to="lab_us-gaap_PreferredStockDividendsPerShareDeclared" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesTradingUnrealizedLoss_595d4970-1019-4a42-b3b4-877eb66df159_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesTradingUnrealizedLoss" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, Unrealized Loss</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesTradingUnrealizedLoss_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesTradingUnrealizedLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, Unrealized Loss</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesTradingUnrealizedLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss" xlink:to="lab_us-gaap_DebtSecuritiesTradingUnrealizedLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_NonRule10b51ArrAdoptedFlag_terseLabel_en-US" xlink:label="lab_ecd_NonRule10b51ArrAdoptedFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Rule 10b5-1 Arrangement Adopted</link:label>
    <link:label id="lab_ecd_NonRule10b51ArrAdoptedFlag_label_en-US" xlink:label="lab_ecd_NonRule10b51ArrAdoptedFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Rule 10b5-1 Arrangement Adopted [Flag]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonRule10b51ArrAdoptedFlag" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_NonRule10b51ArrAdoptedFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_NonRule10b51ArrAdoptedFlag" xlink:to="lab_ecd_NonRule10b51ArrAdoptedFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_FICCMember_776625d0-2678-4fb2-bf1e-f1128a152660_terseLabel_en-US" xlink:label="lab_agnc_FICCMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FICC [Member]</link:label>
    <link:label id="lab_agnc_FICCMember_label_en-US" xlink:label="lab_agnc_FICCMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FICC [Member]</link:label>
    <link:label id="lab_agnc_FICCMember_documentation_en-US" xlink:label="lab_agnc_FICCMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FICC [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FICCMember" xlink:href="agnc-20230930.xsd#agnc_FICCMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_FICCMember" xlink:to="lab_agnc_FICCMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockAuthorizedButNotIssued_cd9484f0-df95-4952-ab63-62a47e1d0f65_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockAuthorizedButNotIssued" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock Authorized, but not Issued</link:label>
    <link:label id="lab_agnc_PreferredStockAuthorizedButNotIssued_label_en-US" xlink:label="lab_agnc_PreferredStockAuthorizedButNotIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock Authorized, but not Issued</link:label>
    <link:label id="lab_agnc_PreferredStockAuthorizedButNotIssued_documentation_en-US" xlink:label="lab_agnc_PreferredStockAuthorizedButNotIssued" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock Authorized, but not Issued</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockAuthorizedButNotIssued" xlink:to="lab_agnc_PreferredStockAuthorizedButNotIssued" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A37to48monthsMember_8b90f927-1caf-4916-ad36-8f853c0a0e91_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">36 to 48 months</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_1bf11799-fdb1-444b-bf1a-1210a6d1a198_terseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_label_en-US" xlink:label="lab_agnc_A37to48monthsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">37 to 48 months [Member]</link:label>
    <link:label id="lab_agnc_A37to48monthsMember_documentation_en-US" xlink:label="lab_agnc_A37to48monthsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">37 to 48 months [Member]</link:label>
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    <link:label id="lab_agnc_ManagementFeeIncome_40266e96-ac9b-4128-b365-f2d4d58353dd_terseLabel_en-US" xlink:label="lab_agnc_ManagementFeeIncome" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Management Fee Income</link:label>
    <link:label id="lab_agnc_ManagementFeeIncome_label_en-US" xlink:label="lab_agnc_ManagementFeeIncome" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Management Fee Income</link:label>
    <link:label id="lab_agnc_ManagementFeeIncome_documentation_en-US" xlink:label="lab_agnc_ManagementFeeIncome" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Management Fee Income</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ManagementFeeIncome" xlink:href="agnc-20230930.xsd#agnc_ManagementFeeIncome"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ManagementFeeIncome" xlink:to="lab_agnc_ManagementFeeIncome" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember_fe13c6c7-db01-42aa-b4f3-df31e55b1853_terseLabel_en-US" xlink:label="lab_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases Of Forward Settling non-Agency Securities</link:label>
    <link:label id="lab_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember_label_en-US" xlink:label="lab_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases Of Forward Settling non-Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember_documentation_en-US" xlink:label="lab_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases Of Forward Settling non-Agency Securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember" xlink:href="agnc-20230930.xsd#agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember" xlink:to="lab_agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_AtCostBasisMember_df77f9ae-e07d-4ace-a51e-d302fe1fcf1b_terseLabel_en-US" xlink:label="lab_agnc_AtCostBasisMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Cost Basis [Member]</link:label>
    <link:label id="lab_agnc_AtCostBasisMember_label_en-US" xlink:label="lab_agnc_AtCostBasisMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Cost Basis [Member]</link:label>
    <link:label id="lab_agnc_AtCostBasisMember_documentation_en-US" xlink:label="lab_agnc_AtCostBasisMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Cost Basis [Member]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AtCostBasisMember" xlink:to="lab_agnc_AtCostBasisMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_c727537f-17e0-4961-9cc6-6adac14c6894_terseLabel_en-US" xlink:label="lab_agnc_CostOfSaleOfAvailableForSaleSecuities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency MBS sold, at cost</link:label>
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    <link:label id="lab_agnc_CostOfSaleOfAvailableForSaleSecuities_documentation_en-US" xlink:label="lab_agnc_CostOfSaleOfAvailableForSaleSecuities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CostOfSaleOfAvailableForSaleSecuities</link:label>
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    <link:label id="lab_us-gaap_SubsequentEventLineItems_570d1e7f-be40-4653-9d47-d14e0a122e40_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event [Line Items]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventLineItems_label_en-US" xlink:label="lab_us-gaap_SubsequentEventLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event [Line Items]</link:label>
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    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_868ff88e-1659-4683-a8a3-5d08d23cd094_terseLabel_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_label_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsAxis_documentation_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative By Maturity Years [Axis]</link:label>
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    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_758cfd32-bd1a-491e-935b-addc17b000be_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months</link:label>
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    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpense_602cab43-038b-4c80-9bd6-ecddeb1883e8_terseLabel_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">General and administrative expenses</link:label>
    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpense_label_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">General and Administrative Expense</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GeneralAndAdministrativeExpense" xlink:to="lab_us-gaap_GeneralAndAdministrativeExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_0b5b74e4-969a-4c9d-91bf-9022fdb5c7e9_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate, at Point in Time</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate_38f4df2e-1d77-4ffc-bc32-b61bd83c18c0_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Interest Rate</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:to="lab_us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardsCloseToMnpiDiscTableTextBlock_terseLabel_en-US" xlink:label="lab_ecd_AwardsCloseToMnpiDiscTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Awards Close in Time to MNPI Disclosures, Table</link:label>
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    <link:label id="lab_agnc_A5YearMaturityMember_737c9db3-846f-44fa-b318-d32046442a3d_terseLabel_en-US" xlink:label="lab_agnc_A5YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">5 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A5YearMaturityMember_label_en-US" xlink:label="lab_agnc_A5YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">5 Year Maturity [Member]</link:label>
    <link:label id="lab_agnc_A5YearMaturityMember_documentation_en-US" xlink:label="lab_agnc_A5YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">5 Year Maturity [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A5YearMaturityMember" xlink:href="agnc-20230930.xsd#agnc_A5YearMaturityMember"/>
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    <link:label id="lab_us-gaap_AssetsCurrent_94ba660e-3dc9-47bc-b346-0d878e9cace9_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency securities transferred to consolidated variable interest entities, at fair value (pledged securities)</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrent" xlink:to="lab_us-gaap_AssetsCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_NetIncomeLossPerCommonShareAbstract_bd33dc26-6a1e-4b36-8671-2ac86f3ca231_terseLabel_en-US" xlink:label="lab_agnc_NetIncomeLossPerCommonShareAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Income (Loss) Per Common Share [Abstract]</link:label>
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    <link:label id="lab_us-gaap_PreferredStockMember_f4add835-aeb6-46ec-80f3-77466caa2d8b_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_PreferredStockMember_label_en-US" xlink:label="lab_us-gaap_PreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock [Member]</link:label>
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    <link:label id="lab_agnc_TransfersBetweenHierarchyLevels_1609dce7-49c8-4c0f-9a1c-f7353a56085c_terseLabel_en-US" xlink:label="lab_agnc_TransfersBetweenHierarchyLevels" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Transfers between hierarchy levels</link:label>
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    <link:label id="lab_us-gaap_TradingSecuritiesDebt_667d7cbd-d978-4746-8615-412337e1d391_terseLabel_en-US" xlink:label="lab_us-gaap_TradingSecuritiesDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecuritiesDebt" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TradingSecuritiesDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecuritiesDebt" xlink:to="lab_us-gaap_TradingSecuritiesDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_8ff3c8b7-91e8-4502-8d66-c76e77b36e17_terseLabel_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage-backed Securities, Issued by US Government Sponsored Enterprises [Member]</link:label>
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    <link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_c48e52db-b85e-4424-9cbd-3d630f7e8c7a_terseLabel_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Supplemental disclosure to cash flow information:</link:label>
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    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_49eee492-477b-4c8f-9e08-fb92a7197657_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash (used in) provided by operating activities</link:label>
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    <link:label id="lab_us-gaap_StatementClassOfStockAxis_ab9111a4-ac22-461e-99cc-db24143a8d9d_terseLabel_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Stock [Axis]</link:label>
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    <link:label id="lab_ecd_ErrCompRecoveryTable_terseLabel_en-US" xlink:label="lab_ecd_ErrCompRecoveryTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Erroneously Awarded Compensation Recovery</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_ecd_ErrCompRecoveryTable" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_ErrCompRecoveryTable"/>
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    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_5a33c017-2396-4ec6-af74-f80d8729fff7_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average&#160;Days to Maturity</link:label>
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    <link:label id="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements Weighted Average Days To Maturity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:href="agnc-20230930.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity"/>
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    <link:label id="lab_agnc_GovernmentAgencyDomain_99355986-4e19-4888-9212-78fb4966b334_terseLabel_en-US" xlink:label="lab_agnc_GovernmentAgencyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Government Agency [Domain]</link:label>
    <link:label id="lab_agnc_GovernmentAgencyDomain_label_en-US" xlink:label="lab_agnc_GovernmentAgencyDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Government Agency [Domain]</link:label>
    <link:label id="lab_agnc_GovernmentAgencyDomain_documentation_en-US" xlink:label="lab_agnc_GovernmentAgencyDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Government Agency [Domain]</link:label>
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    <link:label id="lab_agnc_AtParValueMember_c19b4021-f4c7-4b93-a2b4-d294cc75d598_terseLabel_en-US" xlink:label="lab_agnc_AtParValueMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Par Value [Member]</link:label>
    <link:label id="lab_agnc_AtParValueMember_label_en-US" xlink:label="lab_agnc_AtParValueMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Par Value [Member]</link:label>
    <link:label id="lab_agnc_AtParValueMember_documentation_en-US" xlink:label="lab_agnc_AtParValueMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Par Value [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AtParValueMember" xlink:href="agnc-20230930.xsd#agnc_AtParValueMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AtParValueMember" xlink:to="lab_agnc_AtParValueMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CostofSaleofInvestmentSecurities_432e1258-2cdf-46f5-8225-febbed085c29_negatedTerseLabel_en-US" xlink:label="lab_agnc_CostofSaleofInvestmentSecurities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost of Sale of Investment Securities</link:label>
    <link:label id="lab_agnc_CostofSaleofInvestmentSecurities_label_en-US" xlink:label="lab_agnc_CostofSaleofInvestmentSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost of Sale of Investment Securities</link:label>
    <link:label id="lab_agnc_CostofSaleofInvestmentSecurities_documentation_en-US" xlink:label="lab_agnc_CostofSaleofInvestmentSecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost of Sale of Investment Securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CostofSaleofInvestmentSecurities" xlink:href="agnc-20230930.xsd#agnc_CostofSaleofInvestmentSecurities"/>
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    <link:label id="lab_us-gaap_SeriesGPreferredStockMember_061de385-7b54-4664-a349-6899dc34b0e9_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesGPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series G Preferred Stock</link:label>
    <link:label id="lab_us-gaap_SeriesGPreferredStockMember_label_en-US" xlink:label="lab_us-gaap_SeriesGPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series G Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesGPreferredStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesGPreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesGPreferredStockMember" xlink:to="lab_us-gaap_SeriesGPreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardTmgHowMnpiCnsdrdTextBlock_terseLabel_en-US" xlink:label="lab_ecd_AwardTmgHowMnpiCnsdrdTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing, How MNPI Considered</link:label>
    <link:label id="lab_ecd_AwardTmgHowMnpiCnsdrdTextBlock_label_en-US" xlink:label="lab_ecd_AwardTmgHowMnpiCnsdrdTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing, How MNPI Considered [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgHowMnpiCnsdrdTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardTmgHowMnpiCnsdrdTextBlock"/>
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    <link:label id="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_37bab09c-8c37-49e4-9076-3e611f909b8d_terseLabel_en-US" xlink:label="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive (loss) income (attributable) available to common shareholders</link:label>
    <link:label id="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_label_en-US" xlink:label="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive income available to common shareholders</link:label>
    <link:label id="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders_documentation_en-US" xlink:label="lab_agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive income available to common shareholders</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:href="agnc-20230930.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders"/>
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    <link:label id="lab_dei_EntityInformationLineItems_71d5cf3a-1019-4d1e-96e5-070cad0a8217_terseLabel_en-US" xlink:label="lab_dei_EntityInformationLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Information [Line Items]</link:label>
    <link:label id="lab_dei_EntityInformationLineItems_label_en-US" xlink:label="lab_dei_EntityInformationLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Information [Line Items]</link:label>
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    <link:label id="lab_agnc_PreferredStockBValueIssued_861f89c3-321a-495b-821e-5f218570f41d_verboseLabel_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock B, Value, Issued</link:label>
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    <link:label id="lab_agnc_PreferredStockBValueIssued_documentation_en-US" xlink:label="lab_agnc_PreferredStockBValueIssued" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate par or stated value of issued nonredeemable preferred B stock (or preferred stock B redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within stockholders' equity.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockBValueIssued" xlink:href="agnc-20230930.xsd#agnc_PreferredStockBValueIssued"/>
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    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_a8f5d73b-9191-4fb1-8c17-e44736a1c47c_terseLabel_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Advances, Maturity Period [Domain]</link:label>
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    <link:label id="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_documentation_en-US" xlink:label="lab_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Domain] for Federal Home Loan Bank Advances, Maturity Period [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:href="agnc-20230930.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain"/>
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    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_2fce050c-750e-4a32-a523-74db53cd7716_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Realized Gain</link:label>
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    <link:label id="lab_agnc_PaymentsToAcquireUSTreasurySecurities_1007ca45-3c6c-48af-b72f-608440608ec3_negatedTerseLabel_en-US" xlink:label="lab_agnc_PaymentsToAcquireUSTreasurySecurities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments on U.S. Treasury securities</link:label>
    <link:label id="lab_agnc_PaymentsToAcquireUSTreasurySecurities_label_en-US" xlink:label="lab_agnc_PaymentsToAcquireUSTreasurySecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire U.S. Treasury securities</link:label>
    <link:label id="lab_agnc_PaymentsToAcquireUSTreasurySecurities_documentation_en-US" xlink:label="lab_agnc_PaymentsToAcquireUSTreasurySecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The cash outflow to acquire U.S. Treasury securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PaymentsToAcquireUSTreasurySecurities" xlink:href="agnc-20230930.xsd#agnc_PaymentsToAcquireUSTreasurySecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PaymentsToAcquireUSTreasurySecurities" xlink:to="lab_agnc_PaymentsToAcquireUSTreasurySecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_ConsolidationItemsAxis_a8424310-4577-4849-b301-b26864a845a4_terseLabel_en-US" xlink:label="lab_srt_ConsolidationItemsAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consolidation Items [Axis]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsAxis"/>
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    <link:label id="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_324c8586-b6c0-4edf-ab62-08cd64f2f501_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative liability, fair value</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:to="lab_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:type="arc" order="1"/>
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    <link:label id="lab_us-gaap_AssetsMember_label_en-US" xlink:label="lab_us-gaap_AssetsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsMember" xlink:to="lab_us-gaap_AssetsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_BBBRatingMember_ce2abf44-374a-446a-b060-52f93c482fd2_terseLabel_en-US" xlink:label="lab_agnc_BBBRatingMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">BBB Rating [Member]</link:label>
    <link:label id="lab_agnc_BBBRatingMember_label_en-US" xlink:label="lab_agnc_BBBRatingMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">BBB Rating [Member]</link:label>
    <link:label id="lab_agnc_BBBRatingMember_documentation_en-US" xlink:label="lab_agnc_BBBRatingMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">BBB Rating [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BBBRatingMember" xlink:href="agnc-20230930.xsd#agnc_BBBRatingMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_BBBRatingMember" xlink:to="lab_agnc_BBBRatingMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_UnderPrimeBrokerAgreementsMember_a929049e-4b8b-4e6f-93d5-5a2096d2ce82_terseLabel_en-US" xlink:label="lab_agnc_UnderPrimeBrokerAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Under Prime Broker Agreements [Member]</link:label>
    <link:label id="lab_agnc_UnderPrimeBrokerAgreementsMember_label_en-US" xlink:label="lab_agnc_UnderPrimeBrokerAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Under Prime Broker Agreements [Member]</link:label>
    <link:label id="lab_agnc_UnderPrimeBrokerAgreementsMember_documentation_en-US" xlink:label="lab_agnc_UnderPrimeBrokerAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Under Prime Broker Agreements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember" xlink:href="agnc-20230930.xsd#agnc_UnderPrimeBrokerAgreementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_UnderPrimeBrokerAgreementsMember" xlink:to="lab_agnc_UnderPrimeBrokerAgreementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_db172dab-cc39-4b62-b81a-052044f4afbc_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency securities, at fair value (including pledged securities of $52,250 and $35,800, respectively)</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_ab92896e-8792-4cfd-85b3-8dbd0a667618_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency securities</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instruments, Owned, Mortgages, Mortgage-Backed and Asset-Backed Securities, at Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:to="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_ca81822f-a6ce-4c38-a500-a28ec34f2f18_verboseLabel_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total - (short)/long, net</link:label>
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_f7f0f9ab-d5d9-4ea6-b8a8-fb220991bb75_terseLabel_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">U.S. Treasury securities, net</link:label>
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_label_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">government bonds owned and sold short net</link:label>
    <link:label id="lab_agnc_Governmentbondsownedandsoldshortnet_documentation_en-US" xlink:label="lab_agnc_Governmentbondsownedandsoldshortnet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">government bonds owned and sold short net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet" xlink:href="agnc-20230930.xsd#agnc_Governmentbondsownedandsoldshortnet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Governmentbondsownedandsoldshortnet" xlink:to="lab_agnc_Governmentbondsownedandsoldshortnet" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_PvpTableTextBlock_terseLabel_en-US" xlink:label="lab_ecd_PvpTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pay vs Performance Disclosure, Table</link:label>
    <link:label id="lab_ecd_PvpTableTextBlock_label_en-US" xlink:label="lab_ecd_PvpTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pay vs Performance [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PvpTableTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_PvpTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_PvpTableTextBlock" xlink:to="lab_ecd_PvpTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_fb8d7697-4301-471a-96bc-ddc7ccf458ce_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Antidilutive Securities [Axis]</link:label>
    <link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Antidilutive Securities [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_TrdArrIndTitle_terseLabel_en-US" xlink:label="lab_ecd_TrdArrIndTitle" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title</link:label>
    <link:label id="lab_ecd_TrdArrIndTitle_label_en-US" xlink:label="lab_ecd_TrdArrIndTitle" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Arrangement, Individual Title</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrIndTitle" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_TrdArrIndTitle"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_TrdArrIndTitle" xlink:to="lab_ecd_TrdArrIndTitle" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_8ea8d1be-5e20-4d84-af88-fe150044c50e_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortized Cost</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available For Sale Securities Weighted Average Life Amortized Cost</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">This item represents the weighted average life of available-for-sale agency securities by amortized cost.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" xlink:href="agnc-20230930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost"/>
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    <link:label id="lab_agnc_PledgedFinancialInstrumentsSecurities_19949078-bb61-40eb-b2b0-736a9cde4ed4_terseLabel_en-US" xlink:label="lab_agnc_PledgedFinancialInstrumentsSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Financial Instruments, Securities</link:label>
    <link:label id="lab_agnc_PledgedFinancialInstrumentsSecurities_47b1a5da-9eb6-4a15-80e4-b3e2f3bfe279_negatedTerseLabel_en-US" xlink:label="lab_agnc_PledgedFinancialInstrumentsSecurities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Financial Instruments, Not Separately Reported, Mortgage-Related Securities Available-for-sale or Held-for-investment</link:label>
    <link:label id="lab_agnc_PledgedFinancialInstrumentsSecurities_label_en-US" xlink:label="lab_agnc_PledgedFinancialInstrumentsSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Financial Instruments, Securities</link:label>
    <link:label id="lab_agnc_PledgedFinancialInstrumentsSecurities_documentation_en-US" xlink:label="lab_agnc_PledgedFinancialInstrumentsSecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sum of the carrying amounts as of the date of the latest financial statement presented of securities which are owned but transferred to another party to serve as collateral to partially or fully secure a debt obligation, repurchase agreement or other current or potential obligation, and for which the transferee is not permitted to sell or re-pledge them to an unrelated party.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedFinancialInstrumentsSecurities" xlink:href="agnc-20230930.xsd#agnc_PledgedFinancialInstrumentsSecurities"/>
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    <link:label id="lab_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember_c18ddf37-cc48-4091-b8c4-d13116a4ac4c_terseLabel_en-US" xlink:label="lab_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depositary shares each representing a 1/1000th interest in a share of 7.75% Series G Fixed Rate Reset Cumulative Redeemable Preferred Stock</link:label>
    <link:label id="lab_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember_label_en-US" xlink:label="lab_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depositary shares each representing a 1/1000th interest in a share of 7.75% Series G Fixed Rate Reset Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember_documentation_en-US" xlink:label="lab_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depositary shares each representing a 1/1000th interest in a share of 7.75% Series G Fixed Rate Reset Cumulative Redeemable Preferred Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember" xlink:href="agnc-20230930.xsd#agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember" xlink:to="lab_agnc_DepositarySharesEachRepresentingA11000thInterestInAShareOf775SeriesGFixedRateResetCumulativeRedeemablePreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PositionDomain_fe97feb7-d3ec-4606-beb2-454f29d29fa3_terseLabel_en-US" xlink:label="lab_us-gaap_PositionDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Position [Domain]</link:label>
    <link:label id="lab_us-gaap_PositionDomain_label_en-US" xlink:label="lab_us-gaap_PositionDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Position [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PositionDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PositionDomain" xlink:to="lab_us-gaap_PositionDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockMember_dc974d15-e980-4e46-baaf-0a7b7e9db2b7_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock [Member]</link:label>
    <link:label id="lab_us-gaap_CommonStockMember_label_en-US" xlink:label="lab_us-gaap_CommonStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember" xlink:to="lab_us-gaap_CommonStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_25493494-471d-4d15-9ad2-766f93d8d97d_terseLabel_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_label_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, Value of Shares Remaining for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_documentation_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The remaining dollar value amount approved to issue common stock under an At-the-Market program</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:href="agnc-20230930.xsd#agnc_CommonstockValueofSharesRemainingforFutureIssuance"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:to="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_IndividualAxis_terseLabel_en-US" xlink:label="lab_ecd_IndividualAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Individual:</link:label>
    <link:label id="lab_ecd_IndividualAxis_label_en-US" xlink:label="lab_ecd_IndividualAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Individual [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_IndividualAxis" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_IndividualAxis"/>
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    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_80d3f781-3155-45ae-8a05-aab9f77abe6e_terseLabel_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, Value of Shares Approved for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_label_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, Value of Shares Approved for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_documentation_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The dollar value amount approved to issue common stock under an At-the-Market Offering program.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:href="agnc-20230930.xsd#agnc_CommonstockValueofSharesApprovedforFutureIssuance"/>
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    <link:label id="lab_dei_EntityAddressPostalZipCode_d8f89b6c-6e29-4241-bcab-cb08ea191e1b_terseLabel_en-US" xlink:label="lab_dei_EntityAddressPostalZipCode" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Postal Zip Code</link:label>
    <link:label id="lab_dei_EntityAddressPostalZipCode_label_en-US" xlink:label="lab_dei_EntityAddressPostalZipCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Postal Zip Code</link:label>
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    <link:label id="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_0078ef0c-0bd3-44c5-b270-2bf10382b8ab_terseLabel_en-US" xlink:label="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CMO and Interest Only, Principal Only Securities, Maximum Loss Exposure</link:label>
    <link:label id="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_label_en-US" xlink:label="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CMO and Interest Only, Pricincipal Only Securities, Maximum Loss Exposure</link:label>
    <link:label id="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_documentation_en-US" xlink:label="lab_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CMO and Interest Only and Pricincipal Only Securities, Maximum Loss Exposure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" xlink:href="agnc-20230930.xsd#agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure"/>
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    <link:label id="lab_us-gaap_IncomeStatementLocationDomain_d26b93e5-a452-451b-bda7-163b7e1b971e_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Statement Location [Domain]</link:label>
    <link:label id="lab_us-gaap_IncomeStatementLocationDomain_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Statement Location [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationDomain" xlink:to="lab_us-gaap_IncomeStatementLocationDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_c99a0c2a-0451-4cd6-91fe-7170e3d67e09_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unamortized premium balance</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Unamortized Discount (Premium), Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_74b28495-fa9d-46cb-8a61-140cbf5f5c1d_terseLabel_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average coupon</link:label>
    <link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_label_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt, Weighted Average Interest Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtWeightedAverageInterestRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtWeightedAverageInterestRate" xlink:to="lab_us-gaap_DebtWeightedAverageInterestRate" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_MinimumMember_9139410a-708e-4046-bad5-a137b92572b2_terseLabel_en-US" xlink:label="lab_srt_MinimumMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Minimum [Member]</link:label>
    <link:label id="lab_srt_MinimumMember_label_en-US" xlink:label="lab_srt_MinimumMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Minimum [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_MinimumMember" xlink:to="lab_srt_MinimumMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_82f562aa-d11f-4a8b-853d-d05ce3b37a68_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Two Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_label_en-US" xlink:label="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Two Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_documentation_en-US" xlink:label="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than One Year and Less Than or Equal to Two Years [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:href="agnc-20230930.xsd#agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:to="lab_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_8f18a458-e09d-48af-bc3e-28c07b67af12_verboseLabel_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Income</link:label>
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_c0a5fa5e-a2c6-4e07-84ba-bf7c5bc9bdbb_terseLabel_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Income [Policy Text Block]</link:label>
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_label_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Income [Policy Text Block]</link:label>
    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_documentation_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Income [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestIncomePolicyTextBlock" xlink:href="agnc-20230930.xsd#agnc_InterestIncomePolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestIncomePolicyTextBlock" xlink:to="lab_agnc_InterestIncomePolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareCashPaid_a0212498-b4c8-4adb-99bd-fdd460feaf8a_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareCashPaid" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Dividends, Per Share, Cash Paid</link:label>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareCashPaid_label_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareCashPaid" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Dividends, Per Share, Cash Paid</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockDividendsPerShareCashPaid" xlink:to="lab_us-gaap_CommonStockDividendsPerShareCashPaid" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_b0f7a969-497e-4481-b661-9082705b7b1f_terseLabel_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
    <link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_label_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract" xlink:to="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AssetsAbstract_5881b415-afc7-42f8-9d78-cc953ab6f942_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets:</link:label>
    <link:label id="lab_us-gaap_AssetsAbstract_label_en-US" xlink:label="lab_us-gaap_AssetsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="lab_us-gaap_AssetsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardTmgMnpiDiscTextBlock_terseLabel_en-US" xlink:label="lab_ecd_AwardTmgMnpiDiscTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing MNPI Disclosure</link:label>
    <link:label id="lab_ecd_AwardTmgMnpiDiscTextBlock_label_en-US" xlink:label="lab_ecd_AwardTmgMnpiDiscTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing MNPI Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgMnpiDiscTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardTmgMnpiDiscTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AwardTmgMnpiDiscTextBlock" xlink:to="lab_ecd_AwardTmgMnpiDiscTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ProceedsFromSaleOfDebtSecurities_c5d7cc82-adc9-4a11-8243-d999ad247393_terseLabel_en-US" xlink:label="lab_agnc_ProceedsFromSaleOfDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Sale of Debt Securities</link:label>
    <link:label id="lab_agnc_ProceedsFromSaleOfDebtSecurities_label_en-US" xlink:label="lab_agnc_ProceedsFromSaleOfDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Sale of Debt Securities</link:label>
    <link:label id="lab_agnc_ProceedsFromSaleOfDebtSecurities_documentation_en-US" xlink:label="lab_agnc_ProceedsFromSaleOfDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total amount of cash inflow from sale of investment in debt securities.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsFromSaleOfDebtSecurities" xlink:href="agnc-20230930.xsd#agnc_ProceedsFromSaleOfDebtSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ProceedsFromSaleOfDebtSecurities" xlink:to="lab_agnc_ProceedsFromSaleOfDebtSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LiabilitiesAbstract_06c373e7-f618-41cd-802b-d6caba1dcd42_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities:</link:label>
    <link:label id="lab_us-gaap_LiabilitiesAbstract_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAbstract" xlink:to="lab_us-gaap_LiabilitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_c458e4e5-fd5a-45f1-b135-dd366960c614_terseLabel_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Treasury Securities [Member]</link:label>
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_5dc3a7a3-91e6-4123-bceb-8f66b54d3cc0_verboseLabel_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Treasury Securities [Member]</link:label>
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_label_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Treasury Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USTreasurySecuritiesMember"/>
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    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_92a19fc3-bb47-4358-af92-dbb8002d8771_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash provided by (used in) financing activities</link:label>
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    <link:label id="lab_agnc_BRatingMember_b2fa491b-f9ff-486c-8dfc-0bd5826ee464_terseLabel_en-US" xlink:label="lab_agnc_BRatingMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">B Rating [Member]</link:label>
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    <link:label id="lab_us-gaap_AccountingPoliciesAbstract_8e773f69-73f4-4937-9ae0-dc347bb87e4c_terseLabel_en-US" xlink:label="lab_us-gaap_AccountingPoliciesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Policies [Abstract]</link:label>
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    <link:label id="lab_us-gaap_SaleOfStockNameOfTransactionDomain_5ac162bb-f93a-4afb-9d26-1e574e382bff_terseLabel_en-US" xlink:label="lab_us-gaap_SaleOfStockNameOfTransactionDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sale of Stock [Domain]</link:label>
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    <link:label id="lab_us-gaap_AvailableforsaleSecuritiesMember_b893cf9d-a1a9-47c0-8921-5bb46d506ac1_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableforsaleSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available-for-sale Securities [Member]</link:label>
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    <link:label id="lab_us-gaap_IncomeTaxesPaid_e9394452-e967-4936-bcbd-535a81eabc95_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaid" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Taxes Paid</link:label>
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    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_80e576b8-9cfa-4471-96d5-e1a852e46616_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit risk transfer securities, at fair value (including pledged securities of $709 and $703, respectively)</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:to="lab_us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentTransitionReport_618747e6-0b27-4ae3-8a6a-2f3a30cca56c_terseLabel_en-US" xlink:label="lab_dei_DocumentTransitionReport" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Transition Report</link:label>
    <link:label id="lab_dei_DocumentTransitionReport_label_en-US" xlink:label="lab_dei_DocumentTransitionReport" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Transition Report</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentTransitionReport"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentTransitionReport" xlink:to="lab_dei_DocumentTransitionReport" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardTmgPredtrmndFlag_terseLabel_en-US" xlink:label="lab_ecd_AwardTmgPredtrmndFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing Predetermined</link:label>
    <link:label id="lab_ecd_AwardTmgPredtrmndFlag_label_en-US" xlink:label="lab_ecd_AwardTmgPredtrmndFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing Predetermined [Flag]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgPredtrmndFlag" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardTmgPredtrmndFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AwardTmgPredtrmndFlag" xlink:to="lab_ecd_AwardTmgPredtrmndFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime_4ffec8d2-ab0f-4ba7-997e-21c4c95ff2c7_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term Debt, Weighted Average Interest Rate, over Time</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-Term Debt, Weighted Average Interest Rate, over Time</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime" xlink:to="lab_us-gaap_ShortTermDebtWeightedAverageInterestRateOverTime" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_NonAgencyMember_856aea58-9a51-4d38-8df2-9e88ea0a635c_terseLabel_en-US" xlink:label="lab_agnc_NonAgencyMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Agency [Member]</link:label>
    <link:label id="lab_agnc_NonAgencyMember_label_en-US" xlink:label="lab_agnc_NonAgencyMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Agency [Member]</link:label>
    <link:label id="lab_agnc_NonAgencyMember_documentation_en-US" xlink:label="lab_agnc_NonAgencyMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Agency securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonAgencyMember" xlink:href="agnc-20230930.xsd#agnc_NonAgencyMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NonAgencyMember" xlink:to="lab_agnc_NonAgencyMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_1f25cde8-91fb-48e3-98d1-e7193005fa3b_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Two Years and Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_label_en-US" xlink:label="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Two Years and Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_documentation_en-US" xlink:label="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Two Years and Less Than or Equal to Three Years [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:href="agnc-20230930.xsd#agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:to="lab_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityPublicFloat_d1cd80bd-d65a-4e84-9a0e-81d12369b4a8_terseLabel_en-US" xlink:label="lab_dei_EntityPublicFloat" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Public Float</link:label>
    <link:label id="lab_dei_EntityPublicFloat_label_en-US" xlink:label="lab_dei_EntityPublicFloat" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Public Float</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityPublicFloat" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityPublicFloat"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityPublicFloat" xlink:to="lab_dei_EntityPublicFloat" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_78ee614b-90af-454a-aecd-017cf40f0b2a_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_J.P.MorganSecuritiesLLCMember_f131a2ae-2440-42cf-b784-41842aae56c7_terseLabel_en-US" xlink:label="lab_agnc_J.P.MorganSecuritiesLLCMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">J.P. Morgan Securities, LLC [Member]</link:label>
    <link:label id="lab_agnc_J.P.MorganSecuritiesLLCMember_label_en-US" xlink:label="lab_agnc_J.P.MorganSecuritiesLLCMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">J.P. Morgan Securities, LLC [Member]</link:label>
    <link:label id="lab_agnc_J.P.MorganSecuritiesLLCMember_documentation_en-US" xlink:label="lab_agnc_J.P.MorganSecuritiesLLCMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">J.P. Morgan Securities, LLC [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_J.P.MorganSecuritiesLLCMember" xlink:href="agnc-20230930.xsd#agnc_J.P.MorganSecuritiesLLCMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_J.P.MorganSecuritiesLLCMember" xlink:to="lab_agnc_J.P.MorganSecuritiesLLCMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_SpreadOverLibor_2467e60f-a9dc-418d-9730-6ddb0247d386_terseLabel_en-US" xlink:label="lab_agnc_SpreadOverLibor" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Spread Over LIBOR</link:label>
    <link:label id="lab_agnc_SpreadOverLibor_218f76bf-79c6-4bb8-b30c-85b75cf06856_verboseLabel_en-US" xlink:label="lab_agnc_SpreadOverLibor" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis spread over LIBOR</link:label>
    <link:label id="lab_agnc_SpreadOverLibor_label_en-US" xlink:label="lab_agnc_SpreadOverLibor" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Spread Over LIBOR</link:label>
    <link:label id="lab_agnc_SpreadOverLibor_documentation_en-US" xlink:label="lab_agnc_SpreadOverLibor" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Spread Over LIBOR</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SpreadOverLibor" xlink:href="agnc-20230930.xsd#agnc_SpreadOverLibor"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SpreadOverLibor" xlink:to="lab_agnc_SpreadOverLibor" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_c7bb9138-de29-4c9d-8d24-6c5f965a376e_terseLabel_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 7.000% Series C Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_label_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 7.000% Series C Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_documentation_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 7.000% Series C Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:href="agnc-20230930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:to="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_018363f7-deec-46d1-94f3-9fee39dccee3_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_af901e81-4a38-41bc-909a-b13522e35084_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument Risk [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis" xlink:to="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_7e608886-0b9a-4dbc-a745-44625fd3db75_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value by Liability Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_label_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability Class [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis" xlink:to="lab_us-gaap_FairValueByLiabilityClassAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AllTradingArrangementsMember_terseLabel_en-US" xlink:label="lab_ecd_AllTradingArrangementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">All Trading Arrangements</link:label>
    <link:label id="lab_ecd_AllTradingArrangementsMember_label_en-US" xlink:label="lab_ecd_AllTradingArrangementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">All Trading Arrangements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllTradingArrangementsMember" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllTradingArrangementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AllTradingArrangementsMember" xlink:to="lab_ecd_AllTradingArrangementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AllAdjToCompMember_terseLabel_en-US" xlink:label="lab_ecd_AllAdjToCompMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">All Adjustments to Compensation</link:label>
    <link:label id="lab_ecd_AllAdjToCompMember_label_en-US" xlink:label="lab_ecd_AllAdjToCompMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">All Adjustments to Compensation [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllAdjToCompMember" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllAdjToCompMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="lab_ecd_AllAdjToCompMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A60CouponMember_10ad3b6b-d3a0-4ab5-9fd8-dd43d8d7b9d8_terseLabel_en-US" xlink:label="lab_agnc_A60CouponMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">6.0% Coupon</link:label>
    <link:label id="lab_agnc_A60CouponMember_label_en-US" xlink:label="lab_agnc_A60CouponMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">6.0% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A60CouponMember_documentation_en-US" xlink:label="lab_agnc_A60CouponMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">6.0% Coupon</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A60CouponMember" xlink:href="agnc-20230930.xsd#agnc_A60CouponMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A60CouponMember" xlink:to="lab_agnc_A60CouponMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_c9efa513-d63a-4157-90eb-6f94b7d2bd2c_terseLabel_en-US" xlink:label="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Components of Investment Securities</link:label>
    <link:label id="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_label_en-US" xlink:label="lab_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Components of Investment Securities [Table Text Block]</link:label>
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    <link:label id="lab_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]</link:label>
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    <link:label id="lab_agnc_SecurityTypeDomain_d68e00c9-0b97-4f9e-9ab6-7fb6149b7008_terseLabel_en-US" xlink:label="lab_agnc_SecurityTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Type [Domain]</link:label>
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    <link:label id="lab_agnc_SecurityTypeDomain_documentation_en-US" xlink:label="lab_agnc_SecurityTypeDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Type [Domain]</link:label>
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    <link:label id="lab_us-gaap_InterestIncomeSecuritiesMortgageBacked_25738a35-ae5a-4f4b-a703-2ef51f2f56a2_terseLabel_en-US" xlink:label="lab_us-gaap_InterestIncomeSecuritiesMortgageBacked" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest income</link:label>
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    <link:label id="lab_agnc_DerivativesbyIssuerDomain_3be6a613-b72c-476a-b6bd-c8b0aeccb737_terseLabel_en-US" xlink:label="lab_agnc_DerivativesbyIssuerDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives by Issuer [Domain]</link:label>
    <link:label id="lab_agnc_DerivativesbyIssuerDomain_label_en-US" xlink:label="lab_agnc_DerivativesbyIssuerDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivatives by Issuer [Domain]</link:label>
    <link:label id="lab_agnc_DerivativesbyIssuerDomain_documentation_en-US" xlink:label="lab_agnc_DerivativesbyIssuerDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Domain] for Derivatives by Issuer [Axis]</link:label>
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    <link:label id="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_4b1bdf66-518a-43ba-8328-46499038a779_terseLabel_en-US" xlink:label="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fannie Mae [Member]</link:label>
    <link:label id="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_40b2e75a-2e09-4b77-9199-9c1bdc3beea3_verboseLabel_en-US" xlink:label="lab_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal National Mortgage Association Certificates and Obligations (FNMA) [Member]</link:label>
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    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains_cddce9d7-995a-4872-94eb-f4045f9bb363_terseLabel_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Gross Unrealized Gains</link:label>
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    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains_documentation_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The amount of gross unrealized gains on a available-for-sale securities.</link:label>
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    <link:label id="lab_us-gaap_DerivativeAssets_0df82856-42fb-4d77-92e9-f5a6a6b69a0d_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative assets, at fair value</link:label>
    <link:label id="lab_us-gaap_DerivativeAssets_b61bb8a1-af5b-4e5b-8bff-8c0c79723fbf_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssets" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative assets, at fair value</link:label>
    <link:label id="lab_us-gaap_DerivativeAssets_580f4736-03cd-4f5e-b522-7ebd81de8f2b_negatedLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssets" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">TBA securities</link:label>
    <link:label id="lab_us-gaap_DerivativeAssets_label_en-US" xlink:label="lab_us-gaap_DerivativeAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset</link:label>
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    <link:label id="lab_us-gaap_SubsequentEventTypeAxis_e1e79263-de95-4c10-ad70-7f900ed679f9_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event Type [Axis]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeAxis" xlink:to="lab_us-gaap_SubsequentEventTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeAverageRemainingMaturity1_596477de-c956-4938-81fb-734bbdc4ef35_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAverageRemainingMaturity1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Average Maturity (Years)</link:label>
    <link:label id="lab_us-gaap_DerivativeAverageRemainingMaturity1_label_en-US" xlink:label="lab_us-gaap_DerivativeAverageRemainingMaturity1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative, Average Remaining Maturity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAverageRemainingMaturity1"/>
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    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_c5b7dc74-283b-4859-b01a-41ccce95c6ac_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">U.S. Treasury securities, at fair value (including pledged securities of $246 and $353, respectively)</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_65592c60-ee61-4aca-9fd7-373f46d1234c_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">U.S. Treasury securities</link:label>
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    <link:label id="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_ef629172-56c5-4a06-a873-04b59e1f288d_terseLabel_en-US" xlink:label="lab_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from sale of credit risk transfer and non-Agency securities</link:label>
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    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_157d4261-1b23-4d26-8466-c5034b9b2dba_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amounts reclassified from accumulated OCI</link:label>
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    <link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_08f0275f-c2b2-4a58-a299-635f1dd6ebd2_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Measurements</link:label>
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    <link:label id="lab_agnc_A20YearMaturityMember_38fc3cc7-29df-4bce-9a42-b142ba86b2c2_terseLabel_en-US" xlink:label="lab_agnc_A20YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">20 Year Maturity</link:label>
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    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_609bfb2c-b8b5-4f18-86d0-9c679a970526_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Repurchase of Redeemable Preferred Stock</link:label>
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    <link:label id="lab_us-gaap_EquityAbstract_03b4ccaf-ee24-43b9-a7f2-e113776e4b7d_terseLabel_en-US" xlink:label="lab_us-gaap_EquityAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity [Abstract]</link:label>
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    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount_a10cbf97-18e0-4a92-875e-dc025ee8fb20_terseLabel_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Unamortized discount</link:label>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount_label_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Unamortized Discount</link:label>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount_documentation_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The amount of unamortized discount on available-for-sale securities.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount" xlink:href="agnc-20230930.xsd#agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount" xlink:to="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_271c5510-e47e-458f-b461-b6a5102b9371_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale [Line Items]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_Maturity60To90DaysMember_abc108e7-1426-4638-9184-df2025d9fbf2_terseLabel_en-US" xlink:label="lab_agnc_Maturity60To90DaysMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity 60 To 90 Days [Member]</link:label>
    <link:label id="lab_agnc_Maturity60To90DaysMember_label_en-US" xlink:label="lab_agnc_Maturity60To90DaysMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity 60 To 90 Days [Member]</link:label>
    <link:label id="lab_agnc_Maturity60To90DaysMember_documentation_en-US" xlink:label="lab_agnc_Maturity60To90DaysMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity 60 To 90 Days [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Maturity60To90DaysMember" xlink:href="agnc-20230930.xsd#agnc_Maturity60To90DaysMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Maturity60To90DaysMember" xlink:to="lab_agnc_Maturity60To90DaysMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_e7b89860-7431-47a1-8eea-20e3257505f7_terseLabel_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1000th interest in a share of 6.500% Series E Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_label_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1000th interest in a share of 6.500% Series E Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_documentation_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1000th interest in a share of 6.500% Series E Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:href="agnc-20230930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:to="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock_terseLabel_en-US" xlink:label="lab_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Company Selected Measure</link:label>
    <link:label id="lab_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock_label_en-US" xlink:label="lab_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Company Selected Measure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock" xlink:to="lab_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact_083ed04b-e85e-467c-84c7-c46952ac40cc_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividend on preferred stock</link:label>
    <link:label id="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact_label_en-US" xlink:label="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock Dividends, Income Statement Impact</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:to="lab_us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_89c95bc6-1ddd-4ae2-9749-712039dd96d9_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrealized Loss Position For - Unrealized Loss - Less than 12 Months</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:to="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_0ce563fe-13ac-418e-a942-baf1f025bd68_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and cash equivalents</link:label>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_d5e39633-8d72-4b69-9859-e27c0c38b3de_periodEndLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and cash equivalents at end of period</link:label>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and Cash Equivalents, at Carrying Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_CompActuallyPaidVsOtherMeasureTextBlock_terseLabel_en-US" xlink:label="lab_ecd_CompActuallyPaidVsOtherMeasureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Other Measure</link:label>
    <link:label id="lab_ecd_CompActuallyPaidVsOtherMeasureTextBlock_label_en-US" xlink:label="lab_ecd_CompActuallyPaidVsOtherMeasureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Other Measure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsOtherMeasureTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_CompActuallyPaidVsOtherMeasureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_CompActuallyPaidVsOtherMeasureTextBlock" xlink:to="lab_ecd_CompActuallyPaidVsOtherMeasureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_418b83b3-17fe-4944-b30d-051d58a22384_terseLabel_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_70536d1c-3d08-4a05-b78f-b7fa4d5adde8_verboseLabel_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_label_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:label id="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember_documentation_en-US" xlink:label="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Only And Principal Only Strip [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:href="agnc-20230930.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:to="lab_agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_cf5d58ec-f51c-488a-adb5-1df25f0d6b3c_negatedTerseLabel_en-US" xlink:label="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases of credit risk transfer and non-Agency securities and other mortgage credit investments</link:label>
    <link:label id="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_label_en-US" xlink:label="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments To Acquire Non- Agency Mortgage Backed Securities</link:label>
    <link:label id="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_documentation_en-US" xlink:label="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments To Acquire Non- Agency Mortgage Backed Securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:href="agnc-20230930.xsd#agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:to="lab_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CreditRatingDomain_42d39780-7327-4fd9-a3e3-10524a3fd181_terseLabel_en-US" xlink:label="lab_agnc_CreditRatingDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Rating [Domain]</link:label>
    <link:label id="lab_agnc_CreditRatingDomain_label_en-US" xlink:label="lab_agnc_CreditRatingDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Rating [Domain]</link:label>
    <link:label id="lab_agnc_CreditRatingDomain_documentation_en-US" xlink:label="lab_agnc_CreditRatingDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Domain] for Credit Rating [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRatingDomain" xlink:href="agnc-20230930.xsd#agnc_CreditRatingDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CreditRatingDomain" xlink:to="lab_agnc_CreditRatingDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_7022fd73-dfdf-4e86-bd11-e65d70ea6c22_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities by Credit Rating [Table Text Block]</link:label>
    <link:label id="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_label_en-US" xlink:label="lab_agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities by Credit Rating [Table Text Block]</link:label>
    <link:label id="lab_agnc_SecuritiesbyCreditRatingTableTextBlock_documentation_en-US" xlink:label="lab_agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Table Text Block] for Securities by Credit Rating [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_SecuritiesbyCreditRatingTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:to="lab_agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_aa9b9689-3ff4-4a0c-883b-b35ae9130e97_terseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Paid-in Capital [Member]</link:label>
    <link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Paid-in Capital [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapitalMember" xlink:to="lab_us-gaap_AdditionalPaidInCapitalMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_679cac02-8b2c-4965-b353-994813ec7d17_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Loaned or Sold under Agreements to Repurchase, Fair Value Disclosure</link:label>
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    <link:label id="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_61a2d044-f2aa-456e-b7cd-faac310307d0_terseLabel_en-US" xlink:label="lab_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Summary of Continuous Unrealized Loss Position of Available for Sale Securities</link:label>
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    <link:label id="lab_agnc_OtherLiabilitiesOther_11c2dd4f-392a-4ef8-a942-c10a6b6bc35d_terseLabel_en-US" xlink:label="lab_agnc_OtherLiabilitiesOther" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Liabilities - Other</link:label>
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    <link:label id="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_label_en-US" xlink:label="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds From Principal Collection Of Mortgage Backed Securities Categorized As Available For Sale</link:label>
    <link:label id="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_documentation_en-US" xlink:label="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The cash inflow from collection of principal from borrowers on mortgage backed securities held.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:href="agnc-20230930.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:to="lab_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_eb93f2de-8360-44a1-b7cd-6b4706cdc740_terseLabel_en-US" xlink:label="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Amount Offset in the Consolidated Balance Sheets</link:label>
    <link:label id="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_label_en-US" xlink:label="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Amount Offset in the Consolidated Balance Sheets</link:label>
    <link:label id="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_documentation_en-US" xlink:label="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value before effects of master netting arrangements, of a financial asset or liability or other contract and the contract can be net settled by means outside the contract or delivery of an asset or liability offset in the consolidated balance sheets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:href="agnc-20230930.xsd#agnc_GrossAmountOffsetintheConsolidatedBalanceSheets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:to="lab_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A3.5CouponMember_63e954a2-c2cd-40fb-8c1e-94ecd3136f3f_terseLabel_en-US" xlink:label="lab_agnc_A3.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">3.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A3.5CouponMember_label_en-US" xlink:label="lab_agnc_A3.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">3.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A3.5CouponMember_documentation_en-US" xlink:label="lab_agnc_A3.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">3.5% Coupon [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A3.5CouponMember" xlink:href="agnc-20230930.xsd#agnc_A3.5CouponMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A3.5CouponMember" xlink:to="lab_agnc_A3.5CouponMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockDLiquidationPreferenceValue_7c16e48a-8c50-4117-aeff-e6aa9f22f0e5_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockDLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock D, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockDLiquidationPreferenceValue_label_en-US" xlink:label="lab_agnc_PreferredStockDLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock D, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockDLiquidationPreferenceValue_documentation_en-US" xlink:label="lab_agnc_PreferredStockDLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated values of the preferred D shares.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDLiquidationPreferenceValue" xlink:href="agnc-20230930.xsd#agnc_PreferredStockDLiquidationPreferenceValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockDLiquidationPreferenceValue" xlink:to="lab_agnc_PreferredStockDLiquidationPreferenceValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_7b1b527e-88dd-4dd7-a94c-5d988b63d5a5_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments for Change in Accounting Principle [Axis]</link:label>
    <link:label id="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_label_en-US" xlink:label="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in Accounting Principle, Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:to="lab_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VariableRateDomain_6d13710c-ceba-441b-9d8a-06fed553bd47_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate [Domain]</link:label>
    <link:label id="lab_us-gaap_VariableRateDomain_label_en-US" xlink:label="lab_us-gaap_VariableRateDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableRateDomain" xlink:to="lab_us-gaap_VariableRateDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_PayablesToBrokerDealersAndClearingOrganizations_af7538db-bf4e-44d6-971b-7fdcef0dbe76_terseLabel_en-US" xlink:label="lab_srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payable for investment securities purchased</link:label>
    <link:label id="lab_srt_PayablesToBrokerDealersAndClearingOrganizations_label_en-US" xlink:label="lab_srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Broker-Dealer, Payable to Other Broker-Dealer and Clearing Organization</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_PayablesToBrokerDealersAndClearingOrganizations"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:to="lab_srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_PayVsPerformanceDisclosureLineItems_label_en-US" xlink:label="lab_ecd_PayVsPerformanceDisclosureLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pay vs Performance Disclosure [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_PayVsPerformanceDisclosureLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="lab_ecd_PayVsPerformanceDisclosureLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityVoluntaryFilers_5cf81fc3-550e-4c2b-b7da-fa1c31d15c58_terseLabel_en-US" xlink:label="lab_dei_EntityVoluntaryFilers" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Voluntary Filers</link:label>
    <link:label id="lab_dei_EntityVoluntaryFilers_label_en-US" xlink:label="lab_dei_EntityVoluntaryFilers" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Voluntary Filers</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityVoluntaryFilers"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityVoluntaryFilers" xlink:to="lab_dei_EntityVoluntaryFilers" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RangeMember_1b4c417a-d426-4821-95aa-e3ca8c7fc6f7_terseLabel_en-US" xlink:label="lab_srt_RangeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statistical Measurement [Domain]</link:label>
    <link:label id="lab_srt_RangeMember_label_en-US" xlink:label="lab_srt_RangeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statistical Measurement [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RangeMember" xlink:to="lab_srt_RangeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_604ba179-099e-4b86-8e26-4d7a64133183_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notional Amount</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_05b58c2a-16d9-4472-b053-d66cc18f6987_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Liability, Notional Amount</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_3127d0a1-5fa2-4a68-9a89-f01893b26a1f_negatedPeriodEndLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notional Amount</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Liability, Notional Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilityNotionalAmount" xlink:to="lab_us-gaap_DerivativeLiabilityNotionalAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_UndrlygSecurityMktPriceChngPct_terseLabel_en-US" xlink:label="lab_ecd_UndrlygSecurityMktPriceChngPct" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Underlying Security Market Price Change</link:label>
    <link:label id="lab_ecd_UndrlygSecurityMktPriceChngPct_label_en-US" xlink:label="lab_ecd_UndrlygSecurityMktPriceChngPct" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Underlying Security Market Price Change, Percent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_UndrlygSecurityMktPriceChngPct" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_UndrlygSecurityMktPriceChngPct"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_UndrlygSecurityMktPriceChngPct" xlink:to="lab_ecd_UndrlygSecurityMktPriceChngPct" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_NonDividendDistributionsPerShare_7c709109-974d-49ef-9cca-b4449f52b5d5_terseLabel_en-US" xlink:label="lab_agnc_NonDividendDistributionsPerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Dividend Distributions Per Share</link:label>
    <link:label id="lab_agnc_NonDividendDistributionsPerShare_label_en-US" xlink:label="lab_agnc_NonDividendDistributionsPerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Dividend Distributions Per Share</link:label>
    <link:label id="lab_agnc_NonDividendDistributionsPerShare_documentation_en-US" xlink:label="lab_agnc_NonDividendDistributionsPerShare" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Dividend Distributions Per Share for Tax Purposes</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonDividendDistributionsPerShare" xlink:href="agnc-20230930.xsd#agnc_NonDividendDistributionsPerShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NonDividendDistributionsPerShare" xlink:to="lab_agnc_NonDividendDistributionsPerShare" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredStockLiquidationPreference_e2044588-2507-4ff7-acbc-689987d355c6_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockLiquidationPreference" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Liquidation Preference Per Share</link:label>
    <link:label id="lab_us-gaap_PreferredStockLiquidationPreference_label_en-US" xlink:label="lab_us-gaap_PreferredStockLiquidationPreference" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Liquidation Preference Per Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockLiquidationPreference"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockLiquidationPreference" xlink:to="lab_us-gaap_PreferredStockLiquidationPreference" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LossContingencyDisclosures_56a0a772-23b7-4e30-99c6-4b87266e8ea4_terseLabel_en-US" xlink:label="lab_us-gaap_LossContingencyDisclosures" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingencies Disclosure [Text Block]</link:label>
    <link:label id="lab_us-gaap_LossContingencyDisclosures_label_en-US" xlink:label="lab_us-gaap_LossContingencyDisclosures" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingencies Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDisclosures" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyDisclosures"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LossContingencyDisclosures" xlink:to="lab_us-gaap_LossContingencyDisclosures" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_RestrictedCashandSecuritiesPledged_09055f5a-4cc7-416e-8aa0-f816ba33e678_terseLabel_en-US" xlink:label="lab_agnc_RestrictedCashandSecuritiesPledged" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Cash and Securities Pledged</link:label>
    <link:label id="lab_agnc_RestrictedCashandSecuritiesPledged_label_en-US" xlink:label="lab_agnc_RestrictedCashandSecuritiesPledged" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Cash and Securities Pledged</link:label>
    <link:label id="lab_agnc_RestrictedCashandSecuritiesPledged_documentation_en-US" xlink:label="lab_agnc_RestrictedCashandSecuritiesPledged" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Cash and Securities Pledged</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RestrictedCashandSecuritiesPledged" xlink:href="agnc-20230930.xsd#agnc_RestrictedCashandSecuritiesPledged"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RestrictedCashandSecuritiesPledged" xlink:to="lab_agnc_RestrictedCashandSecuritiesPledged" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_LessThanOrEqualToFiveYearsMember_1ffb995f-4455-459f-9eb3-996f9e2f2d35_terseLabel_en-US" xlink:label="lab_agnc_LessThanOrEqualToFiveYearsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to Five Years</link:label>
    <link:label id="lab_agnc_LessThanOrEqualToFiveYearsMember_label_en-US" xlink:label="lab_agnc_LessThanOrEqualToFiveYearsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to Five Years [Member]</link:label>
    <link:label id="lab_agnc_LessThanOrEqualToFiveYearsMember_documentation_en-US" xlink:label="lab_agnc_LessThanOrEqualToFiveYearsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to Five Years</link:label>
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    <link:label id="lab_us-gaap_TradingSecurities_51e3fd52-1e83-4b0c-bbd5-104727674930_terseLabel_en-US" xlink:label="lab_us-gaap_TradingSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, and Equity Securities, FV-NI</link:label>
    <link:label id="lab_us-gaap_TradingSecurities_label_en-US" xlink:label="lab_us-gaap_TradingSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, and Equity Securities, FV-NI</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TradingSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradingSecurities" xlink:to="lab_us-gaap_TradingSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementOfStockholdersEquityAbstract_0c280f8b-5460-496c-89f7-0966ca002565_terseLabel_en-US" xlink:label="lab_us-gaap_StatementOfStockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Stockholders' Equity [Abstract]</link:label>
    <link:label id="lab_us-gaap_StatementOfStockholdersEquityAbstract_label_en-US" xlink:label="lab_us-gaap_StatementOfStockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Stockholders' Equity [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract" xlink:to="lab_us-gaap_StatementOfStockholdersEquityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium_ae34c0d1-a6e0-4ccc-a963-578482d7926c_terseLabel_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Unamortized premium</link:label>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium_label_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Unamortized Premium</link:label>
    <link:label id="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium_documentation_en-US" xlink:label="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The amount of unamortized premium on available-for-sale securities.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium" xlink:href="agnc-20230930.xsd#agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium" xlink:to="lab_agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue_6487a9ed-427e-4506-ac39-481c8eee7a4a_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Owned and Pledged as Collateral, Fair Value</link:label>
    <link:label id="lab_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue_label_en-US" xlink:label="lab_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Owned and Pledged as Collateral, Fair Value</link:label>
    <link:label id="lab_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue_documentation_en-US" xlink:label="lab_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of financial instrument held by the entity for its own account for trading or investment purposes that are carried at fair value and pledged to counterparties as collateral for financing transactions.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue" xlink:href="agnc-20230930.xsd#agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue" xlink:to="lab_agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_52f1d5da-98e2-4c6e-ba66-f38194648e52_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments, Debt and Equity Securities [Abstract]</link:label>
    <link:label id="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_label_en-US" xlink:label="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments, Debt and Equity Securities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:to="lab_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_2a7140ac-c030-45be-9cd1-48e83defc884_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Primary Beneficiary [Member]</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Primary Beneficiary [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_d10c36ca-1a84-475b-a24b-4995f01838dc_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Description of Variable Rate Basis</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_7d842d33-9e48-41b5-a53e-8c7175194960_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Description of variable rate basis</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Description of Variable Rate Basis</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:to="lab_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsMember_d5d9a677-1f51-4e45-9a8f-afa47ad6596d_terseLabel_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reverse Repurchase Agreements [Member]</link:label>
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsMember_label_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reverse Repurchase Agreements [Member]</link:label>
    <link:label id="lab_agnc_ReverseRepurchaseAgreementsMember_documentation_en-US" xlink:label="lab_agnc_ReverseRepurchaseAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reverse Repurchase Agreements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember" xlink:href="agnc-20230930.xsd#agnc_ReverseRepurchaseAgreementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ReverseRepurchaseAgreementsMember" xlink:to="lab_agnc_ReverseRepurchaseAgreementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ReceivableforsecuritiessoldMember_50bcf84c-74e3-4842-849c-2ccaa123815b_terseLabel_en-US" xlink:label="lab_agnc_ReceivableforsecuritiessoldMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable for securities sold [Member]</link:label>
    <link:label id="lab_agnc_ReceivableforsecuritiessoldMember_label_en-US" xlink:label="lab_agnc_ReceivableforsecuritiessoldMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable for securities sold [Member]</link:label>
    <link:label id="lab_agnc_ReceivableforsecuritiessoldMember_documentation_en-US" xlink:label="lab_agnc_ReceivableforsecuritiessoldMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable for securities sold [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceivableforsecuritiessoldMember" xlink:href="agnc-20230930.xsd#agnc_ReceivableforsecuritiessoldMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ReceivableforsecuritiessoldMember" xlink:to="lab_agnc_ReceivableforsecuritiessoldMember" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_MnpiDiscTimedForCompValFlag_terseLabel_en-US" xlink:label="lab_ecd_MnpiDiscTimedForCompValFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">MNPI Disclosure Timed for Compensation Value</link:label>
    <link:label id="lab_ecd_MnpiDiscTimedForCompValFlag_label_en-US" xlink:label="lab_ecd_MnpiDiscTimedForCompValFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">MNPI Disclosure Timed for Compensation Value [Flag]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_MnpiDiscTimedForCompValFlag" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_MnpiDiscTimedForCompValFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_MnpiDiscTimedForCompValFlag" xlink:to="lab_ecd_MnpiDiscTimedForCompValFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_RestatementDateAxis_terseLabel_en-US" xlink:label="lab_ecd_RestatementDateAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restatement Determination Date:</link:label>
    <link:label id="lab_ecd_RestatementDateAxis_label_en-US" xlink:label="lab_ecd_RestatementDateAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restatement Determination Date [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_RestatementDateAxis" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_RestatementDateAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_RestatementDateAxis" xlink:to="lab_ecd_RestatementDateAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_9d602b0c-c152-4e50-b7f7-1124f5a8efce_verboseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements</link:label>
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_c8462609-73fb-484e-a706-a207bac52709_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Sold under Agreements to Repurchase</link:label>
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_label_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Sold under Agreements to Repurchase</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NonoperatingIncomeExpense_c129e493-a052-43e0-8e12-9fc3bb0d3655_terseLabel_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Nonoperating Income (Expense)</link:label>
    <link:label id="lab_us-gaap_NonoperatingIncomeExpense_label_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Nonoperating Income (Expense)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NonoperatingIncomeExpense" xlink:to="lab_us-gaap_NonoperatingIncomeExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SeriesEPreferredStockMember_0f984453-7216-4abc-95a5-ef1462a793e1_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesEPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series E Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_SeriesEPreferredStockMember_label_en-US" xlink:label="lab_us-gaap_SeriesEPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series E Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesEPreferredStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesEPreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesEPreferredStockMember" xlink:to="lab_us-gaap_SeriesEPreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfCommonStock_29751de8-764b-418d-b4d7-36d412a1cb85_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net proceeds from common stock issuance</link:label>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfCommonStock_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Issuance of Common Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:to="lab_us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_39f3d2b6-0d54-45d4-b2cc-6a722f4bc477_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Disclosure [Text Block]</link:label>
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    <link:label id="lab_us-gaap_FutureMember_c5b2b4cc-04bd-4e0d-8d45-2a9de1b9b84d_terseLabel_en-US" xlink:label="lab_us-gaap_FutureMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Future [Member]</link:label>
    <link:label id="lab_us-gaap_FutureMember_label_en-US" xlink:label="lab_us-gaap_FutureMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Future [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FutureMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FutureMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FutureMember" xlink:to="lab_us-gaap_FutureMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A10to12MonthsMember_74237823-cf7f-44ac-9878-886b6134ef91_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">10 to 12 Months [Member]</link:label>
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    <link:label id="lab_us-gaap_OtherLiabilitiesTableTextBlock_ede56e75-1ffa-472a-9f32-bd9f3f402ce9_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Liabilities</link:label>
    <link:label id="lab_us-gaap_OtherLiabilitiesTableTextBlock_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Liabilities [Table Text Block]</link:label>
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    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_c10b9041-6350-4c81-a7bb-c56c157cdf29_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares Issued, Shares, Share-based Payment Arrangement, before Forfeiture</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares Issued, Shares, Share-Based Payment Arrangement, before Forfeiture</link:label>
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    <link:label id="lab_agnc_WeightedAverageForwardStartDays_71aba99d-ccb5-4387-8396-17df6a515db3_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDays" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Forward Start Days</link:label>
    <link:label id="lab_agnc_WeightedAverageForwardStartDays_label_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDays" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Forward Start Days</link:label>
    <link:label id="lab_agnc_WeightedAverageForwardStartDays_documentation_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDays" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Forward Start Days</link:label>
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    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_26fbc165-6664-40fc-a4d6-dff976ede9aa_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for preferred stock redemptions</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock"/>
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    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d53e7df6-a758-451a-af69-879364a5207a_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Table]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Recurring and Nonrecurring [Table]</link:label>
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    <link:label id="lab_ecd_PeoTotalCompAmt_terseLabel_en-US" xlink:label="lab_ecd_PeoTotalCompAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">PEO Total Compensation Amount</link:label>
    <link:label id="lab_ecd_PeoTotalCompAmt_label_en-US" xlink:label="lab_ecd_PeoTotalCompAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">PEO Total Compensation Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeoTotalCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_PeoTotalCompAmt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_PeoTotalCompAmt" xlink:to="lab_ecd_PeoTotalCompAmt" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_AtCarryingValueMember_74c3e557-b66b-44e6-9383-025aaa37f128_terseLabel_en-US" xlink:label="lab_agnc_AtCarryingValueMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Carrying Value</link:label>
    <link:label id="lab_agnc_AtCarryingValueMember_label_en-US" xlink:label="lab_agnc_AtCarryingValueMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">At Carrying Value [Member]</link:label>
    <link:label id="lab_agnc_AtCarryingValueMember_documentation_en-US" xlink:label="lab_agnc_AtCarryingValueMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Carrying Value</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AtCarryingValueMember" xlink:to="lab_agnc_AtCarryingValueMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_fd82bfa4-2d95-4a79-b36d-633bc3a84218_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Relationship [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Relationship [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
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    <link:label id="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_40dab870-057e-4c3f-8a84-5d7bf83696dd_terseLabel_en-US" xlink:label="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intended annual distribution of taxable net income</link:label>
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    <link:label id="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome_documentation_en-US" xlink:label="lab_agnc_IntendedAnnualDistributionofTaxableNetIncome" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intended Annual Distribution of Taxable Net Income</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome" xlink:href="agnc-20230930.xsd#agnc_IntendedAnnualDistributionofTaxableNetIncome"/>
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    <link:label id="lab_ecd_TradingArrByIndTable_terseLabel_en-US" xlink:label="lab_ecd_TradingArrByIndTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Arrangements, by Individual</link:label>
    <link:label id="lab_ecd_TradingArrByIndTable_label_en-US" xlink:label="lab_ecd_TradingArrByIndTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Arrangements, by Individual [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TradingArrByIndTable" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_TradingArrByIndTable"/>
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    <link:label id="lab_agnc_LessThanorEqualtoThreeYearsMember_17e5b39c-25fb-44bd-9ce3-166e1bc21043_terseLabel_en-US" xlink:label="lab_agnc_LessThanorEqualtoThreeYearsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_LessThanorEqualtoThreeYearsMember_label_en-US" xlink:label="lab_agnc_LessThanorEqualtoThreeYearsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to Three Years [Member]</link:label>
    <link:label id="lab_agnc_LessThanorEqualtoThreeYearsMember_documentation_en-US" xlink:label="lab_agnc_LessThanorEqualtoThreeYearsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less Than or Equal to Three Years</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LessThanorEqualtoThreeYearsMember" xlink:href="agnc-20230930.xsd#agnc_LessThanorEqualtoThreeYearsMember"/>
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    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_ab49120d-9b4d-4bc0-88a9-1be5d339cb0b_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
    <link:label id="lab_us-gaap_FederalHomeLoanBankStock_label_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankStock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankStock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FederalHomeLoanBankStock"/>
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    <link:label id="lab_ecd_NonPeoNeoAvgCompActuallyPaidAmt_terseLabel_en-US" xlink:label="lab_ecd_NonPeoNeoAvgCompActuallyPaidAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-PEO NEO Average Compensation Actually Paid Amount</link:label>
    <link:label id="lab_ecd_NonPeoNeoAvgCompActuallyPaidAmt_label_en-US" xlink:label="lab_ecd_NonPeoNeoAvgCompActuallyPaidAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-PEO NEO Average Compensation Actually Paid Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonPeoNeoAvgCompActuallyPaidAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_NonPeoNeoAvgCompActuallyPaidAmt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_NonPeoNeoAvgCompActuallyPaidAmt" xlink:to="lab_ecd_NonPeoNeoAvgCompActuallyPaidAmt" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetIncomeLoss_77aababe-9f59-446c-9977-7495f4a2a915_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net loss</link:label>
    <link:label id="lab_us-gaap_NetIncomeLoss_9b164ea5-8073-4adc-938c-5a6c311028bd_verboseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss)</link:label>
    <link:label id="lab_us-gaap_NetIncomeLoss_label_en-US" xlink:label="lab_us-gaap_NetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Income (Loss)</link:label>
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    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_162771e8-3b3d-48f6-921f-f3bb16264f61_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets [Line Items]</link:label>
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    <link:label id="lab_agnc_A15YearMaturityMember_abdb3407-4e1b-43b3-99c9-86d65c7b4a17_terseLabel_en-US" xlink:label="lab_agnc_A15YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">15 Year Maturity [Member]</link:label>
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    <link:label id="lab_agnc_A15YearMaturityMember_documentation_en-US" xlink:label="lab_agnc_A15YearMaturityMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">15 Year Maturity [Member]</link:label>
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    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodValue_f2d298e2-1d7f-4bda-a918-a6521aaf2532_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period, Value</link:label>
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    <link:label id="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_376d60fc-1b05-4510-8013-b125a108c71d_terseLabel_en-US" xlink:label="lab_agnc_CostandProceedsofInvestmentSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost and Proceeds of Investment Securities [Member]</link:label>
    <link:label id="lab_agnc_CostandProceedsofInvestmentSecuritiesMember_label_en-US" xlink:label="lab_agnc_CostandProceedsofInvestmentSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost and Proceeds of Investment Securities [Member]</link:label>
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    <link:label id="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_166f4e1c-83ac-427f-8aab-582013bcb0a0_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term Debt, Percentage Bearing Fixed Interest Rate</link:label>
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    <link:label id="lab_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_2c5eb96e-e8ad-47a9-bf2e-517b0e0268e3_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Received as Collateral, Amount Repledged and Sold</link:label>
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    <link:label id="lab_us-gaap_InterestRateSwaptionMember_5de868d9-045e-4be3-8cca-7847958689e8_terseLabel_en-US" xlink:label="lab_us-gaap_InterestRateSwaptionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Swaption [Member]</link:label>
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    <link:label id="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_797a063f-1f7c-4395-b954-6c60ac0141dd_terseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive Income, Policy [Policy Text Block]</link:label>
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    <link:label id="lab_agnc_Maturity31To59DaysMember_3d4923e8-9489-4fae-8cd1-ead17a82cc4b_terseLabel_en-US" xlink:label="lab_agnc_Maturity31To59DaysMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity 31 To 59 Days [Member]</link:label>
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    <link:label id="lab_ecd_MeasureName_terseLabel_en-US" xlink:label="lab_ecd_MeasureName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name</link:label>
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    <link:label id="lab_agnc_ThirtyOneToNinetyMember_64245592-a61b-4eee-b2fc-777c10b52313_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">1 to 3 Months</link:label>
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    <link:label id="lab_ecd_ForgoneRecoveryIndName_terseLabel_en-US" xlink:label="lab_ecd_ForgoneRecoveryIndName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name</link:label>
    <link:label id="lab_ecd_ForgoneRecoveryIndName_label_en-US" xlink:label="lab_ecd_ForgoneRecoveryIndName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forgone Recovery, Individual Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ForgoneRecoveryIndName" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_ForgoneRecoveryIndName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_ForgoneRecoveryIndName" xlink:to="lab_ecd_ForgoneRecoveryIndName" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_57a86292-195d-4696-9b53-e9b993ba52cd_verboseLabel_en-US" xlink:label="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain on derivative instruments and other securities, net</link:label>
    <link:label id="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_label_en-US" xlink:label="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loss On Derivative Instruments And Trading Securities Net</link:label>
    <link:label id="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_documentation_en-US" xlink:label="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loss on derivative instruments and trading securities, net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:href="agnc-20230930.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:to="lab_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_Goodwill_15859209-326e-49c3-adae-b807a5af6a1d_terseLabel_en-US" xlink:label="lab_us-gaap_Goodwill" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill</link:label>
    <link:label id="lab_us-gaap_Goodwill_label_en-US" xlink:label="lab_us-gaap_Goodwill" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill" xlink:to="lab_us-gaap_Goodwill" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockELiquidationPreferenceValue_874252d6-91e4-46fa-a967-a7bbb3b1ab9b_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockELiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock E, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockELiquidationPreferenceValue_label_en-US" xlink:label="lab_agnc_PreferredStockELiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock E, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockELiquidationPreferenceValue_documentation_en-US" xlink:label="lab_agnc_PreferredStockELiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated value of the preferred E shares</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockELiquidationPreferenceValue" xlink:href="agnc-20230930.xsd#agnc_PreferredStockELiquidationPreferenceValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockELiquidationPreferenceValue" xlink:to="lab_agnc_PreferredStockELiquidationPreferenceValue" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardUndrlygSecuritiesAmt_terseLabel_en-US" xlink:label="lab_ecd_AwardUndrlygSecuritiesAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Underlying Securities</link:label>
    <link:label id="lab_ecd_AwardUndrlygSecuritiesAmt_label_en-US" xlink:label="lab_ecd_AwardUndrlygSecuritiesAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Underlying Securities Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardUndrlygSecuritiesAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardUndrlygSecuritiesAmt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AwardUndrlygSecuritiesAmt" xlink:to="lab_ecd_AwardUndrlygSecuritiesAmt" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_0caf6cbc-e7d0-4724-85e5-c15a6a762cfa_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends declared per common share</link:label>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_71e99144-6215-4769-92f4-d2b712d5b7c3_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Dividends, Per Share, Declared</link:label>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_label_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Dividends, Per Share, Declared</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockDividendsPerShareDeclared" xlink:to="lab_us-gaap_CommonStockDividendsPerShareDeclared" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable_a584b01e-cbe4-4396-89d7-8f810d350716_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Available-for-sale Securities [Table]</link:label>
    <link:label id="lab_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable_label_en-US" xlink:label="lab_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of investment Securities by Issuer [Table]</link:label>
    <link:label id="lab_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable_documentation_en-US" xlink:label="lab_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of investment Securities by Issuer</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable" xlink:href="agnc-20230930.xsd#agnc_ScheduleOfInvestmentSecuritiesByIssuerTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable" xlink:to="lab_agnc_ScheduleOfInvestmentSecuritiesByIssuerTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_b92badd7-1128-423c-9f26-97196d8aaae1_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_f4f39147-574f-4d09-868a-5d5d7183e8c7_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrealized Gains and (Losses), Net</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A49to60MonthsMember_f3aa12fb-d76b-47e4-80e1-075fcee3b32e_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">48 to 60 Months</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_5721fc3e-f031-4e15-8119-a33a9a412172_terseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_label_en-US" xlink:label="lab_agnc_A49to60MonthsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:label id="lab_agnc_A49to60MonthsMember_documentation_en-US" xlink:label="lab_agnc_A49to60MonthsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">49 to 60 Months [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A49to60MonthsMember" xlink:href="agnc-20230930.xsd#agnc_A49to60MonthsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A49to60MonthsMember" xlink:to="lab_agnc_A49to60MonthsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockCLiquidationPreferenceValue_556de3cf-e726-47ef-8e07-4719f9665fca_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockCLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock C, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockCLiquidationPreferenceValue_label_en-US" xlink:label="lab_agnc_PreferredStockCLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock C, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockCLiquidationPreferenceValue_documentation_en-US" xlink:label="lab_agnc_PreferredStockCLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated values of the preferred C shares.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue" xlink:href="agnc-20230930.xsd#agnc_PreferredStockCLiquidationPreferenceValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockCLiquidationPreferenceValue" xlink:to="lab_agnc_PreferredStockCLiquidationPreferenceValue" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CounterpartyExposureNet_1cd07303-eff8-41f1-a665-8c48f832038e_terseLabel_en-US" xlink:label="lab_agnc_CounterpartyExposureNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Exposure, Net</link:label>
    <link:label id="lab_agnc_CounterpartyExposureNet_label_en-US" xlink:label="lab_agnc_CounterpartyExposureNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Exposure, Net</link:label>
    <link:label id="lab_agnc_CounterpartyExposureNet_documentation_en-US" xlink:label="lab_agnc_CounterpartyExposureNet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Represents the net carrying value of the securities pledged under repurchase agreements, including accrued interest plus any cash or assets on deposit to secure the repurchase obligation, less the amount of the repurchase liability, including accrued interest.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CounterpartyExposureNet" xlink:href="agnc-20230930.xsd#agnc_CounterpartyExposureNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CounterpartyExposureNet" xlink:to="lab_agnc_CounterpartyExposureNet" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A13to24MonthsMember_7093402e-3274-48b9-839a-5727f512ed7b_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A13to24MonthsMember" xlink:href="agnc-20230930.xsd#agnc_A13to24MonthsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember" xlink:to="lab_agnc_A13to24MonthsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_75a937a0-04b6-407c-938c-d485ee8e6b96_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentNameDomain" xlink:to="lab_us-gaap_DebtInstrumentNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_SecuritizedCmoSecurities_5a8b9554-4da4-440d-8f74-ef086659f723_verboseLabel_en-US" xlink:label="lab_agnc_SecuritizedCmoSecurities" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securitized CMO Securities</link:label>
    <link:label id="lab_agnc_SecuritizedCmoSecurities_label_en-US" xlink:label="lab_agnc_SecuritizedCmoSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securitized CMO Securities</link:label>
    <link:label id="lab_agnc_SecuritizedCmoSecurities_documentation_en-US" xlink:label="lab_agnc_SecuritizedCmoSecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The sum of the fair values, as of the date of each statement of financial position presented, of directly held CMO securities and interest-only securities including retained interest in transfers treated as sales and the fair value of securities held by consolidated CMO trusts.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritizedCmoSecurities" xlink:href="agnc-20230930.xsd#agnc_SecuritizedCmoSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritizedCmoSecurities" xlink:to="lab_agnc_SecuritizedCmoSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_5e77c2b6-a7f1-4fe1-bc0a-5e68b6cbf555_terseLabel_en-US" xlink:label="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Amounts of Assets Presented in the Consolidated Balance Sheets</link:label>
    <link:label id="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_label_en-US" xlink:label="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Amount of Assets (Liabilities) Presented on the Balance Sheet</link:label>
    <link:label id="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_documentation_en-US" xlink:label="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value after effects of master netting arrangements, of a financial asset or liability or other contract and the contract can be net settled by means outside the contract or delivery of an asset or liability.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:href="agnc-20230930.xsd#agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:to="lab_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:type="arc" order="1"/>
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    <link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_54a4cdf1-dc5e-4058-abd3-007fe0d20f52_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and Cash Equivalents, Policy [Policy Text Block]</link:label>
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    <link:label id="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_label_en-US" xlink:label="lab_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Government National Mortgage Association Certificates and Obligations (GNMA) [Member]</link:label>
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    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_ad761a7d-5831-409c-b4bb-cb29f6e5fe92_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Coupon</link:label>
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    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">This item represents the weighted average life of available-for-sale agency securities by weighted average coupon rate.</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" xlink:to="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommercialMortgageBackedSecuritiesMember_d4f6da03-271e-4771-8eb6-60c0e269f552_terseLabel_en-US" xlink:label="lab_us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Mortgage Backed Securities [Member]</link:label>
    <link:label id="lab_us-gaap_CommercialMortgageBackedSecuritiesMember_label_en-US" xlink:label="lab_us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Mortgage-Backed Securities [Member]</link:label>
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    <link:label id="lab_ecd_OtherPerfMeasureAmt_terseLabel_en-US" xlink:label="lab_ecd_OtherPerfMeasureAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Performance Measure, Amount</link:label>
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    <link:label id="lab_agnc_InterestRateReceiveSwapMember_96a5761c-453b-45d8-aa51-63c5d0a34a0c_terseLabel_en-US" xlink:label="lab_agnc_InterestRateReceiveSwapMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Receive Swap</link:label>
    <link:label id="lab_agnc_InterestRateReceiveSwapMember_label_en-US" xlink:label="lab_agnc_InterestRateReceiveSwapMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Receive Swap [Member]</link:label>
    <link:label id="lab_agnc_InterestRateReceiveSwapMember_documentation_en-US" xlink:label="lab_agnc_InterestRateReceiveSwapMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Receive Swap</link:label>
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    <link:label id="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_cafeb357-3399-44b0-a58a-ffd8e8f6535e_terseLabel_en-US" xlink:label="lab_agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Swaps Excluding Forward Starting [Member]</link:label>
    <link:label id="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_label_en-US" xlink:label="lab_agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Swaps Excluding Forward Starting [Member]</link:label>
    <link:label id="lab_agnc_InterestRateSwapsExcludingForwardStartingMember_documentation_en-US" xlink:label="lab_agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Swaps Excluding Forward Starting [Member]</link:label>
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    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_93403114-de21-46ed-acef-694f329061ed_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investing activities:</link:label>
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    <link:label id="lab_us-gaap_PlanNameDomain_6b4e3489-3239-4ba9-8e3f-8216508eb671_terseLabel_en-US" xlink:label="lab_us-gaap_PlanNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Plan Name [Domain]</link:label>
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    <link:label id="lab_agnc_Issuancecostsofredeemedpreferredstock_ad785919-7f53-4c29-ae18-826563fa72c6_terseLabel_en-US" xlink:label="lab_agnc_Issuancecostsofredeemedpreferredstock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Issuance costs of redeemed preferred stock</link:label>
    <link:label id="lab_agnc_Issuancecostsofredeemedpreferredstock_c741983c-b5d6-4bf9-96d2-dd1768fe76eb_negatedTerseLabel_en-US" xlink:label="lab_agnc_Issuancecostsofredeemedpreferredstock" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Issuance costs of redeemed preferred stock</link:label>
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    <link:label id="lab_agnc_Issuancecostsofredeemedpreferredstock_documentation_en-US" xlink:label="lab_agnc_Issuancecostsofredeemedpreferredstock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Costs associated with the issuance of redeemed preferred stock</link:label>
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    <link:label id="lab_agnc_PreferredStockPercentInterestPerShare_72aa6548-afcc-4a18-8a07-4a462e3e3bcc_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockPercentInterestPerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Percent Interest Per Share</link:label>
    <link:label id="lab_agnc_PreferredStockPercentInterestPerShare_label_en-US" xlink:label="lab_agnc_PreferredStockPercentInterestPerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Percent Interest Per Share</link:label>
    <link:label id="lab_agnc_PreferredStockPercentInterestPerShare_documentation_en-US" xlink:label="lab_agnc_PreferredStockPercentInterestPerShare" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Percent Interest Per Share</link:label>
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    <link:label id="lab_us-gaap_InterestExpense_72a0bfc5-1630-4767-86be-6eae5e0cd5c9_terseLabel_en-US" xlink:label="lab_us-gaap_InterestExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest expense</link:label>
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    <link:label id="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_1c0bb55c-77d9-4048-b9c0-94d26e046ae0_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Trading Securities and Other Trading Assets [Table]</link:label>
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    <link:label id="lab_us-gaap_FairValueByAssetClassAxis_43914feb-fdfe-4233-9318-d2ffa26839fa_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Asset Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByAssetClassAxis_label_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Asset Class [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByAssetClassAxis" xlink:to="lab_us-gaap_FairValueByAssetClassAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_StockRepurchasedDuringPeriodTradeDateShares_c75b7e09-b150-4e99-aa84-d167600368f3_terseLabel_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodTradeDateShares" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period Purchase Date, Shares</link:label>
    <link:label id="lab_agnc_StockRepurchasedDuringPeriodTradeDateShares_label_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodTradeDateShares" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period Trade Date, Shares</link:label>
    <link:label id="lab_agnc_StockRepurchasedDuringPeriodTradeDateShares_documentation_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodTradeDateShares" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of shares that have been repurchased during the period, including shares that settled after the period, and have not been retired and are not held in treasury.</link:label>
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    <link:label id="lab_us-gaap_SubsequentEventsPolicyPolicyTextBlock_349bb4c7-c181-43c5-87e7-70de7e08645a_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventsPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Events, Policy</link:label>
    <link:label id="lab_us-gaap_SubsequentEventsPolicyPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_SubsequentEventsPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Events, Policy [Policy Text Block]</link:label>
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    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_d04c7672-39d1-4a92-aeb9-cbbb015a7a77_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
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    <link:label id="lab_us-gaap_CommonStockSharesIssued_83276054-f95b-4ced-b5b9-199f5ee7a212_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares, Issued</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesIssued_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares, Issued</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesIssued"/>
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    <link:label id="lab_agnc_PreferredStockDividendPaymentRateVariableRateSpread_12ca1dc5-0278-4cdb-bdc8-674982c326db_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockDividendPaymentRateVariableRateSpread" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock Dividend Payment Rate Variable Rate Spread</link:label>
    <link:label id="lab_agnc_PreferredStockDividendPaymentRateVariableRateSpread_label_en-US" xlink:label="lab_agnc_PreferredStockDividendPaymentRateVariableRateSpread" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock Dividend Payment Rate Variable Rate Spread</link:label>
    <link:label id="lab_agnc_PreferredStockDividendPaymentRateVariableRateSpread_documentation_en-US" xlink:label="lab_agnc_PreferredStockDividendPaymentRateVariableRateSpread" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The percentage rate spread over three-month libor used to calculate dividend payments on preferred stock</link:label>
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    <link:label id="lab_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember_b2dcd8cf-0260-4109-8921-1c9c772f50bc_terseLabel_en-US" xlink:label="lab_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sale Of TBA And Forward Settling Agency Securities [Member]</link:label>
    <link:label id="lab_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember_label_en-US" xlink:label="lab_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sale Of TBA And Forward Settling Securities [Member]</link:label>
    <link:label id="lab_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember_documentation_en-US" xlink:label="lab_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sale Of T B A And Forward Settling Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember" xlink:href="agnc-20230930.xsd#agnc_SaleOfTBAAndForwardSettlingSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember" xlink:to="lab_agnc_SaleOfTBAAndForwardSettlingSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_fac9620f-8413-4831-8f99-96b9624b5347_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total assets</link:label>
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
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    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_31eafb03-8814-4adb-8ec3-7ffddbf5b4e7_negatedTotalLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrealized Loss Position For - Unrealized Loss - Total</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
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    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_ef1049ea-a5f4-43c4-8b7a-26ce657ff39f_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]</link:label>
    <link:label id="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_label_en-US" xlink:label="lab_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis"/>
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    <link:label id="lab_us-gaap_DerivativeAverageFixedInterestRate_44e5339f-b4a3-4ecb-bd0c-af3178977672_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAverageFixedInterestRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative, Average Fixed Interest Rate</link:label>
    <link:label id="lab_us-gaap_DerivativeAverageFixedInterestRate_d7208fac-3665-4438-bfd7-02ae355c8a88_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAverageFixedInterestRate" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Average Fixed Pay Rate</link:label>
    <link:label id="lab_us-gaap_DerivativeAverageFixedInterestRate_label_en-US" xlink:label="lab_us-gaap_DerivativeAverageFixedInterestRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative, Average Fixed Interest Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAverageFixedInterestRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAverageFixedInterestRate" xlink:to="lab_us-gaap_DerivativeAverageFixedInterestRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_c18fc1e5-f46e-421c-8e42-1bedc079808a_terseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive (loss) income</link:label>
    <link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive Income (Loss), Net of Tax, Attributable to Parent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SeriesFPreferredStockMember_2cf63d27-ff0d-4f91-99bb-bbb1c273d79c_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesFPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series F Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_SeriesFPreferredStockMember_label_en-US" xlink:label="lab_us-gaap_SeriesFPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series F Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesFPreferredStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesFPreferredStockMember"/>
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    <link:label id="lab_us-gaap_InterestPaid_bafb41b9-cb49-41e7-bca6-595baa7fae8a_terseLabel_en-US" xlink:label="lab_us-gaap_InterestPaid" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Paid, Including Capitalized Interest, Operating and Investing Activities</link:label>
    <link:label id="lab_us-gaap_InterestPaid_label_en-US" xlink:label="lab_us-gaap_InterestPaid" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Paid, Including Capitalized Interest, Operating and Investing Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaid" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestPaid"/>
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    <link:label id="lab_dei_EntityAddressAddressLine1_64c57f2a-09ce-49e5-a550-b65f5248edec_terseLabel_en-US" xlink:label="lab_dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line One</link:label>
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    <link:label id="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_label_en-US" xlink:label="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedules Of Securities Pledged As Collateral Under Repurchase Agreement [Text Block] [Table Text Block]</link:label>
    <link:label id="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_documentation_en-US" xlink:label="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedules Of Securities Pledged As Collateral Under Repurchase Agreement [Text Block] [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:to="lab_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ClassOfStockLineItems_db2b882f-392d-499c-bd2d-e1f5ca560bd4_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Stock [Line Items]</link:label>
    <link:label id="lab_us-gaap_ClassOfStockLineItems_label_en-US" xlink:label="lab_us-gaap_ClassOfStockLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Stock [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockLineItems"/>
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    <link:label id="lab_agnc_DerivativePositionDomain_7aa810d0-6c4e-4e8b-8919-fd255282deb7_terseLabel_en-US" xlink:label="lab_agnc_DerivativePositionDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Position [Domain]</link:label>
    <link:label id="lab_agnc_DerivativePositionDomain_label_en-US" xlink:label="lab_agnc_DerivativePositionDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Position [Domain]</link:label>
    <link:label id="lab_agnc_DerivativePositionDomain_documentation_en-US" xlink:label="lab_agnc_DerivativePositionDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Position [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativePositionDomain" xlink:href="agnc-20230930.xsd#agnc_DerivativePositionDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativePositionDomain" xlink:to="lab_agnc_DerivativePositionDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GainLossOnOtherDebt_815512fb-d294-444d-a79c-fadf10e6713f_terseLabel_en-US" xlink:label="lab_agnc_GainLossOnOtherDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain Loss on Other Debt</link:label>
    <link:label id="lab_agnc_GainLossOnOtherDebt_label_en-US" xlink:label="lab_agnc_GainLossOnOtherDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain Loss on Other Debt</link:label>
    <link:label id="lab_agnc_GainLossOnOtherDebt_documentation_en-US" xlink:label="lab_agnc_GainLossOnOtherDebt" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain Loss on Other Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GainLossOnOtherDebt" xlink:href="agnc-20230930.xsd#agnc_GainLossOnOtherDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GainLossOnOtherDebt" xlink:to="lab_agnc_GainLossOnOtherDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_09fb5720-ad5f-4251-9c37-2911312e7e4e_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_86ea4c84-d4a5-4002-8cff-b31d07596e5d_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentAxis" xlink:to="lab_us-gaap_FinancialInstrumentAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_f184932a-028e-4e52-91f8-80d3d822bfa9_terseLabel_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 7.750% Series B Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_label_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 7.750% Series B Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_documentation_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 7.750% Series B Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:href="agnc-20230930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:to="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeMember_9e5c0009-bc78-4faf-a328-880edcae5a50_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative [Member]</link:label>
    <link:label id="lab_us-gaap_DerivativeMember_label_en-US" xlink:label="lab_us-gaap_DerivativeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeMember" xlink:to="lab_us-gaap_DerivativeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InterestReceivable_686f15c8-ea4b-4523-acb4-a68676e0dede_terseLabel_en-US" xlink:label="lab_us-gaap_InterestReceivable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Receivable</link:label>
    <link:label id="lab_us-gaap_InterestReceivable_label_en-US" xlink:label="lab_us-gaap_InterestReceivable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Receivable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivable" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestReceivable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestReceivable" xlink:to="lab_us-gaap_InterestReceivable" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue_cd8cf3cd-85d6-44bb-be5b-5d0f1eee7efe_terseLabel_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period Settled After Period - Value</link:label>
    <link:label id="lab_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue_label_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period Settled After Period - Value</link:label>
    <link:label id="lab_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue_documentation_en-US" xlink:label="lab_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity impact of the value of stock that has been repurchased during the period and has not been retired and is not held in treasury but that settled after the period. Some state laws may mandate the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue" xlink:href="agnc-20230930.xsd#agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue" xlink:to="lab_agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt_fb5de671-58a9-40ed-bec1-fdc1d39f5272_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Remaining Maturity of Repurchase Agreements Extinguished - Extinguished Debt</link:label>
    <link:label id="lab_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt_label_en-US" xlink:label="lab_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Remaining Maturity of Repurchase Agreements Extinguished - Extinguished Debt</link:label>
    <link:label id="lab_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt_documentation_en-US" xlink:label="lab_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Remaining Maturity of Repurchase Agreements Extinguished - Extinguished Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" xlink:href="agnc-20230930.xsd#agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" xlink:to="lab_agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_VariableInterestEntitiesAbstract_e8b097cb-7f98-4728-bdae-6df1397c6ae1_terseLabel_en-US" xlink:label="lab_agnc_VariableInterestEntitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entities [Abstract]</link:label>
    <link:label id="lab_agnc_VariableInterestEntitiesAbstract_label_en-US" xlink:label="lab_agnc_VariableInterestEntitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entities [Abstract]</link:label>
    <link:label id="lab_agnc_VariableInterestEntitiesAbstract_documentation_en-US" xlink:label="lab_agnc_VariableInterestEntitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_VariableInterestEntitiesAbstract" xlink:href="agnc-20230930.xsd#agnc_VariableInterestEntitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_VariableInterestEntitiesAbstract" xlink:to="lab_agnc_VariableInterestEntitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_TotalShareholderRtnAmt_terseLabel_en-US" xlink:label="lab_ecd_TotalShareholderRtnAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Shareholder Return Amount</link:label>
    <link:label id="lab_ecd_TotalShareholderRtnAmt_label_en-US" xlink:label="lab_ecd_TotalShareholderRtnAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Shareholder Return Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TotalShareholderRtnAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_TotalShareholderRtnAmt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_TotalShareholderRtnAmt" xlink:to="lab_ecd_TotalShareholderRtnAmt" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_8b7e7895-baca-4477-aae9-24aa40c4a940_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Repurchase of Common Stock</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_1977cbd5-c92f-49d8-890e-d9b71322c8b1_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for common stock repurchases</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_e88014b3-326d-452f-b380-546587af0ec4_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Repurchase of Common Stock</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_label_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Repurchase of Common Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:to="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityCommonStockSharesOutstanding_65b61b50-b800-4bd1-b886-bb54f5579d95_terseLabel_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Common Stock, Shares Outstanding</link:label>
    <link:label id="lab_dei_EntityCommonStockSharesOutstanding_label_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Common Stock, Shares Outstanding</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCommonStockSharesOutstanding" xlink:to="lab_dei_EntityCommonStockSharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ProceedsFromSaleOfDebtSecuritiesTrading_00479096-a7b3-48c5-8758-a65659639a21_terseLabel_en-US" xlink:label="lab_agnc_ProceedsFromSaleOfDebtSecuritiesTrading" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Sale of Debt Securities, Trading</link:label>
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    <link:label id="lab_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock_terseLabel_en-US" xlink:label="lab_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Total Shareholder Return</link:label>
    <link:label id="lab_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock_label_en-US" xlink:label="lab_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Total Shareholder Return [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock" xlink:to="lab_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShortMember_f77bced1-03c5-47ce-9b66-781541781155_terseLabel_en-US" xlink:label="lab_us-gaap_ShortMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short [Member]</link:label>
    <link:label id="lab_us-gaap_ShortMember_label_en-US" xlink:label="lab_us-gaap_ShortMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortMember" xlink:to="lab_us-gaap_ShortMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_7f2646b8-38c1-4631-9d98-84ffd5a8cfcd_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating activities:</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Operating Activities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_c456c9eb-53d3-415f-91d2-680b50772e57_terseLabel_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency Securities Pledged As Collateral Accrued Interest</link:label>
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_label_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency Securities Pledged As Collateral Accrued Interest</link:label>
    <link:label id="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_documentation_en-US" xlink:label="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Item represents accrued interest on agency securities pledged as collateral.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:href="agnc-20230930.xsd#agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:to="lab_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PayerSwaptionMember_1d50ae0d-636e-4531-b3f2-f963ede494b6_terseLabel_en-US" xlink:label="lab_agnc_PayerSwaptionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payer Swaption [Member]</link:label>
    <link:label id="lab_agnc_PayerSwaptionMember_label_en-US" xlink:label="lab_agnc_PayerSwaptionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payer Swaption [Member]</link:label>
    <link:label id="lab_agnc_PayerSwaptionMember_documentation_en-US" xlink:label="lab_agnc_PayerSwaptionMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payer Swaption [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PayerSwaptionMember" xlink:href="agnc-20230930.xsd#agnc_PayerSwaptionMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PayerSwaptionMember" xlink:to="lab_agnc_PayerSwaptionMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_d4c1afcf-1ba6-4026-88c6-1f0a4ad4d92a_terseLabel_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Table]</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_label_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Table]</link:label>
    <link:label id="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_documentation_en-US" xlink:label="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase Agreements with Counterparties Greater than or equal to 5% of Equity at Risk [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:href="agnc-20230930.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:to="lab_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromShortTermDebt_ebf1189d-f0cd-41e3-abcc-9191828a827d_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromShortTermDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from repurchase arrangements</link:label>
    <link:label id="lab_us-gaap_ProceedsFromShortTermDebt_label_en-US" xlink:label="lab_us-gaap_ProceedsFromShortTermDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Short-Term Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromShortTermDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromShortTermDebt" xlink:to="lab_us-gaap_ProceedsFromShortTermDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_OtherAssetsTableTextBlock_565f482d-2fbf-42bb-b109-ad7fcb1e6e3a_terseLabel_en-US" xlink:label="lab_agnc_OtherAssetsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets [Table]</link:label>
    <link:label id="lab_agnc_OtherAssetsTableTextBlock_label_en-US" xlink:label="lab_agnc_OtherAssetsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets [Table Text Block]</link:label>
    <link:label id="lab_agnc_OtherAssetsTableTextBlock_documentation_en-US" xlink:label="lab_agnc_OtherAssetsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Other Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_OtherAssetsTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherAssetsTableTextBlock" xlink:to="lab_agnc_OtherAssetsTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_UnderlyingCollateralCoupon_812a41d7-12d0-4c67-835b-cfb059f95429_terseLabel_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Underlying Collateral Coupon</link:label>
    <link:label id="lab_agnc_UnderlyingCollateralCoupon_label_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Underlying Collateral Coupon</link:label>
    <link:label id="lab_agnc_UnderlyingCollateralCoupon_documentation_en-US" xlink:label="lab_agnc_UnderlyingCollateralCoupon" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Underlying Collateral Coupon</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_UnderlyingCollateralCoupon" xlink:href="agnc-20230930.xsd#agnc_UnderlyingCollateralCoupon"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_UnderlyingCollateralCoupon" xlink:to="lab_agnc_UnderlyingCollateralCoupon" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PledgedAssetsTextBlock_38ab12be-dc86-4491-b132-9999696ed964_terseLabel_en-US" xlink:label="lab_agnc_PledgedAssetsTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Assets</link:label>
    <link:label id="lab_agnc_PledgedAssetsTextBlock_label_en-US" xlink:label="lab_agnc_PledgedAssetsTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Assets [Text Block]</link:label>
    <link:label id="lab_agnc_PledgedAssetsTextBlock_documentation_en-US" xlink:label="lab_agnc_PledgedAssetsTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Assets [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PledgedAssetsTextBlock" xlink:href="agnc-20230930.xsd#agnc_PledgedAssetsTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PledgedAssetsTextBlock" xlink:to="lab_agnc_PledgedAssetsTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3c95909e-7d34-4b00-bd3a-889fbd62282d_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Asset Class [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_f1c4e623-359a-48f2-9818-293105f511c3_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, by Asset Class [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Asset Class [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_5bc90db4-baae-438f-9db3-0e66edd7d21e_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net long TBA position, at fair value</link:label>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_5896dc33-7d51-4560-ad13-2511aeb0c3e1_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset, Fair Value, Gross Asset</link:label>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_98c62623-4bb5-47d1-811c-7ba284f0d151_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset, Fair Value, Gross Asset</link:label>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset, Subject to Master Netting Arrangement, before Offset</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ARatingMember_1a4f4fef-7d9a-4450-9cfa-c8fc4520f8e4_terseLabel_en-US" xlink:label="lab_agnc_ARatingMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">A Rating [Member]</link:label>
    <link:label id="lab_agnc_ARatingMember_label_en-US" xlink:label="lab_agnc_ARatingMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">A Rating [Member]</link:label>
    <link:label id="lab_agnc_ARatingMember_documentation_en-US" xlink:label="lab_agnc_ARatingMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">A Rating [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ARatingMember" xlink:href="agnc-20230930.xsd#agnc_ARatingMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ARatingMember" xlink:to="lab_agnc_ARatingMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ClassOfStockDomain_9221485e-56ad-4d69-85f5-974e010c216c_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Stock [Domain]</link:label>
    <link:label id="lab_us-gaap_ClassOfStockDomain_label_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Stock [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfStockDomain" xlink:to="lab_us-gaap_ClassOfStockDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PayableForUnsettledTransactions_9c74e67d-642d-4739-ab29-4f2a67a8686b_terseLabel_en-US" xlink:label="lab_agnc_PayableForUnsettledTransactions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payable for Unsettled Transactions</link:label>
    <link:label id="lab_agnc_PayableForUnsettledTransactions_label_en-US" xlink:label="lab_agnc_PayableForUnsettledTransactions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payable for Unsettled Transactions</link:label>
    <link:label id="lab_agnc_PayableForUnsettledTransactions_documentation_en-US" xlink:label="lab_agnc_PayableForUnsettledTransactions" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount payable for transactions that are unsettled</link:label>
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    <link:label id="lab_us-gaap_SecuritiesAssetsMember_2b3507a4-4fe3-4f94-b289-ea0a22743741_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesAssetsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities (Assets) [Member]</link:label>
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    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_083f6431-8720-45bb-8578-2b41041b290a_verboseLabel_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Organization</link:label>
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    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f59b7dcf-703a-41c6-82f3-acc95dab9c0d_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss) [Member]</link:label>
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    <link:label id="lab_ecd_AggtErrCompAmt_terseLabel_en-US" xlink:label="lab_ecd_AggtErrCompAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate Erroneous Compensation Amount</link:label>
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    <link:label id="lab_ecd_AllExecutiveCategoriesMember_terseLabel_en-US" xlink:label="lab_ecd_AllExecutiveCategoriesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">All Executive Categories</link:label>
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    <link:label id="lab_agnc_ForwardSettlingNonAgencySecuritiesMember_89e46a52-90f1-448f-976d-c08496a04e3c_terseLabel_en-US" xlink:label="lab_agnc_ForwardSettlingNonAgencySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forward Settling non-Agency Securities</link:label>
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    <link:label id="lab_agnc_PledgedAssetsAbstract_58b45c2c-ee47-4926-baa8-72791d3ec8c5_terseLabel_en-US" xlink:label="lab_agnc_PledgedAssetsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Assets [Abstract]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_MultifamilyMember" xlink:to="lab_srt_MultifamilyMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredStockSharesOutstanding_94425442-da3d-4caa-9655-f6efc8e94adc_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Shares Outstanding</link:label>
    <link:label id="lab_us-gaap_PreferredStockSharesOutstanding_label_en-US" xlink:label="lab_us-gaap_PreferredStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Shares Outstanding</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockSharesOutstanding" xlink:to="lab_us-gaap_PreferredStockSharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_WeightedAverageCouponRate_1c355a4e-d75e-4a80-b36d-72f26c81e4b1_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageCouponRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Coupon Rate</link:label>
    <link:label id="lab_agnc_WeightedAverageCouponRate_label_en-US" xlink:label="lab_agnc_WeightedAverageCouponRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Coupon Rate</link:label>
    <link:label id="lab_agnc_WeightedAverageCouponRate_documentation_en-US" xlink:label="lab_agnc_WeightedAverageCouponRate" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Coupon Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageCouponRate" xlink:href="agnc-20230930.xsd#agnc_WeightedAverageCouponRate"/>
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    <link:label id="lab_agnc_BethesdaSecuritiesMember_98d8599d-c9f6-436d-a316-501704bf751c_terseLabel_en-US" xlink:label="lab_agnc_BethesdaSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bethesda Securities [Member]</link:label>
    <link:label id="lab_agnc_BethesdaSecuritiesMember_label_en-US" xlink:label="lab_agnc_BethesdaSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bethesda Securities [Member]</link:label>
    <link:label id="lab_agnc_BethesdaSecuritiesMember_documentation_en-US" xlink:label="lab_agnc_BethesdaSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bethesda Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_BethesdaSecuritiesMember" xlink:href="agnc-20230930.xsd#agnc_BethesdaSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_BethesdaSecuritiesMember" xlink:to="lab_agnc_BethesdaSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesTradingUnrealizedGain_9a518f62-159a-4de3-9d23-6fb068e89d77_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesTradingUnrealizedGain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, Unrealized Gain</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesTradingUnrealizedGain_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesTradingUnrealizedGain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Trading, Unrealized Gain</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedGain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesTradingUnrealizedGain"/>
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    <link:label id="lab_agnc_A4to6MonthsMember_b4469906-84df-4cc2-8441-1b6defef2506_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">3 to 6 Months</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_ef8fd5c6-ea15-4141-8895-a5635f4c4a9c_verboseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_label_en-US" xlink:label="lab_agnc_A4to6MonthsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:label id="lab_agnc_A4to6MonthsMember_documentation_en-US" xlink:label="lab_agnc_A4to6MonthsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4 to 6 Months [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A4to6MonthsMember" xlink:href="agnc-20230930.xsd#agnc_A4to6MonthsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember" xlink:to="lab_agnc_A4to6MonthsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CreditRiskTransferSecuritiesMember_da3b604b-e0f3-4d16-9c50-14b5110b4eb2_terseLabel_en-US" xlink:label="lab_agnc_CreditRiskTransferSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Risk Transfer Securities [Member]</link:label>
    <link:label id="lab_agnc_CreditRiskTransferSecuritiesMember_label_en-US" xlink:label="lab_agnc_CreditRiskTransferSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Risk Transfer Securities [Member]</link:label>
    <link:label id="lab_agnc_CreditRiskTransferSecuritiesMember_documentation_en-US" xlink:label="lab_agnc_CreditRiskTransferSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">GSE Credit Risk Transfer Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember" xlink:href="agnc-20230930.xsd#agnc_CreditRiskTransferSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CreditRiskTransferSecuritiesMember" xlink:to="lab_agnc_CreditRiskTransferSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_405d35db-2529-459d-b2ac-6f09d7af6bb9_terseLabel_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Financial Position [Abstract]</link:label>
    <link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_label_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Financial Position [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract" xlink:to="lab_us-gaap_StatementOfFinancialPositionAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredUnitsByNameAxis_efe532bc-046f-4104-beea-9c5156448546_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredUnitsByNameAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Units by Name [Axis]</link:label>
    <link:label id="lab_us-gaap_PreferredUnitsByNameAxis_label_en-US" xlink:label="lab_us-gaap_PreferredUnitsByNameAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Units by Name [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredUnitsByNameAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis" xlink:to="lab_us-gaap_PreferredUnitsByNameAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockholdersEquity_f5a97105-cfe4-452d-99e5-09153daab4bd_totalLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total stockholders' equity</link:label>
    <link:label id="lab_us-gaap_StockholdersEquity_b876de09-3910-4ee4-ba55-cb11318732bd_periodStartLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance, value</link:label>
    <link:label id="lab_us-gaap_StockholdersEquity_20065d04-a5a1-41bd-bc05-54162d069a1e_periodEndLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance, value</link:label>
    <link:label id="lab_us-gaap_StockholdersEquity_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity, Attributable to Parent</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity" xlink:to="lab_us-gaap_StockholdersEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_79c76fa1-048b-40ac-af78-1362e493e1a0_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:to="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2d40a206-a6c9-44f4-a390-5ee8c727e3d1_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfStockByClassTable_718f1dc1-412d-4ec4-9fc7-9ab7638571af_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfStockByClassTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Stock by Class [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfStockByClassTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfStockByClassTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Stock by Class [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable" xlink:to="lab_us-gaap_ScheduleOfStockByClassTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SubsequentEventsAbstract_12379af6-76c4-43c1-9ba1-0240bd6b2aed_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Events [Abstract]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventsAbstract" xlink:to="lab_us-gaap_SubsequentEventsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ReceivableForUnsettledTransactions_ba726396-42ee-4db6-a761-0d10e93353ea_terseLabel_en-US" xlink:label="lab_agnc_ReceivableForUnsettledTransactions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable for Unsettled Transactions</link:label>
    <link:label id="lab_agnc_ReceivableForUnsettledTransactions_label_en-US" xlink:label="lab_agnc_ReceivableForUnsettledTransactions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable for Unsettled Transactions</link:label>
    <link:label id="lab_agnc_ReceivableForUnsettledTransactions_documentation_en-US" xlink:label="lab_agnc_ReceivableForUnsettledTransactions" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount receivable for transactions that are unsettled</link:label>
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    <link:label id="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_c9eebc53-da66-4245-b03c-8e9d8eb1703f_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net proceeds from (payments on) reverse repurchase agreements</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:to="lab_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_7752f848-5e74-453c-bc8b-b1aa2da63d76_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Measurement, Policy</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock" xlink:to="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NondesignatedMember_0fbf238e-0a63-468d-804d-42c8c088b773_terseLabel_en-US" xlink:label="lab_us-gaap_NondesignatedMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Not Designated as Hedging Instrument [Member]</link:label>
    <link:label id="lab_us-gaap_NondesignatedMember_label_en-US" xlink:label="lab_us-gaap_NondesignatedMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Not Designated as Hedging Instrument [Member]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NondesignatedMember" xlink:to="lab_us-gaap_NondesignatedMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_HedgingDesignationDomain_ff32ef99-7d54-40ff-ab73-e96b05275d6d_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Designation [Domain]</link:label>
    <link:label id="lab_us-gaap_HedgingDesignationDomain_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Designation [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationDomain" xlink:to="lab_us-gaap_HedgingDesignationDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_4dc969ec-0978-4f74-941f-e682aa44ccf6_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Inputs, Level 2 [Member]</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Inputs, Level 2 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member" xlink:to="lab_us-gaap_FairValueInputsLevel2Member" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_f5b1ebda-9361-4852-a51a-d9e06d3f0229_terseLabel_en-US" xlink:label="lab_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency securities transferred to consolidated variable interest entities, at fair value (pledged securities)</link:label>
    <link:label id="lab_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_label_en-US" xlink:label="lab_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency securities transferred to consolidated variable interest entities, at fair value</link:label>
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    <link:label id="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_7f2a2b5c-61a8-404d-ad28-62c843f2cd76_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net gain (loss) on sale of investment securities</link:label>
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    <link:label id="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_label_en-US" xlink:label="lab_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (Loss) on Sales of Mortgage-Backed Securities (MBS)</link:label>
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    <link:label id="lab_us-gaap_PreferredStockLiquidationPreferenceValue_b38689b0-b7d7-44da-be64-92e0a653bf0b_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Liquidation Preference, Value</link:label>
    <link:label id="lab_us-gaap_PreferredStockLiquidationPreferenceValue_label_en-US" xlink:label="lab_us-gaap_PreferredStockLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Liquidation Preference, Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockLiquidationPreferenceValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockLiquidationPreferenceValue" xlink:to="lab_us-gaap_PreferredStockLiquidationPreferenceValue" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_DerivativePositionAxis_e8263e12-9ef3-4963-aa8a-c625e5d39546_terseLabel_en-US" xlink:label="lab_agnc_DerivativePositionAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Position [Axis]</link:label>
    <link:label id="lab_agnc_DerivativePositionAxis_label_en-US" xlink:label="lab_agnc_DerivativePositionAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Position [Axis]</link:label>
    <link:label id="lab_agnc_DerivativePositionAxis_documentation_en-US" xlink:label="lab_agnc_DerivativePositionAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Position [Axis]</link:label>
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    <link:label id="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_502f76dc-20db-463c-8555-a179cbe07b8a_terseLabel_en-US" xlink:label="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Risk of interest swap and swaption agreements to stockholders' equity</link:label>
    <link:label id="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted_label_en-US" xlink:label="lab_us-gaap_CreditDerivativeMaximumExposureUndiscounted" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Derivative, Maximum Exposure, Undiscounted</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditDerivativeMaximumExposureUndiscounted"/>
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    <link:label id="lab_agnc_PreferredStockDividednRatePercentageBasisSpread_3cf60fae-d7bf-43f3-98ee-df4607b0513f_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockDividednRatePercentageBasisSpread" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividedn Rate, Percentage, Basis Spread</link:label>
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    <link:label id="lab_agnc_PreferredStockDividednRatePercentageBasisSpread_documentation_en-US" xlink:label="lab_agnc_PreferredStockDividednRatePercentageBasisSpread" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividedn Rate, Percentage, Basis Spread</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDividednRatePercentageBasisSpread" xlink:href="agnc-20230930.xsd#agnc_PreferredStockDividednRatePercentageBasisSpread"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockDividednRatePercentageBasisSpread" xlink:to="lab_agnc_PreferredStockDividednRatePercentageBasisSpread" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_b54ed236-efc7-44ef-8fc7-9a187e5f0411_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable"/>
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    <link:label id="lab_ecd_NamedExecutiveOfficersFnTextBlock_terseLabel_en-US" xlink:label="lab_ecd_NamedExecutiveOfficersFnTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Named Executive Officers, Footnote</link:label>
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    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_f4631e82-a3df-478a-8aff-8e9e554c587d_verboseLabel_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average expected constant prepayment rate</link:label>
    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_53b5344a-7bb3-4e13-8793-7aa6d0e29b49_terseLabel_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Future Prepayment Rate Assumption Of Investment Portfolio</link:label>
    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_label_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Future Prepayment Rate Assumption Of Investment Portfolio</link:label>
    <link:label id="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_documentation_en-US" xlink:label="lab_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Average future constant repayment rate assumption of Investment Portfolio.</link:label>
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    <link:label id="lab_dei_DocumentFiscalPeriodFocus_a5226083-54be-4f98-a241-afb4055a1e11_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Fiscal Period Focus</link:label>
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    <link:label id="lab_us-gaap_ShareBasedCompensation_2421235e-f27a-4e08-9d6b-577aef825b13_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock based compensation</link:label>
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    <link:label id="lab_dei_CityAreaCode_dcf81de9-82fe-483b-8b93-7b6eb1fc980d_terseLabel_en-US" xlink:label="lab_dei_CityAreaCode" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">City Area Code</link:label>
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    <link:label id="lab_agnc_SecurityTypeAxis_d4b8743f-8db7-4261-a600-2fbee54ba085_terseLabel_en-US" xlink:label="lab_agnc_SecurityTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Government Agency [Axis]</link:label>
    <link:label id="lab_agnc_SecurityTypeAxis_label_en-US" xlink:label="lab_agnc_SecurityTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Type [Axis]</link:label>
    <link:label id="lab_agnc_SecurityTypeAxis_documentation_en-US" xlink:label="lab_agnc_SecurityTypeAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Type</link:label>
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    <link:label id="lab_us-gaap_SwaptionMember_bca88c35-64eb-4b3a-9895-8c9be4d97c4c_terseLabel_en-US" xlink:label="lab_us-gaap_SwaptionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">ERROR in label resolution.</link:label>
    <link:label id="lab_us-gaap_SwaptionMember_label_en-US" xlink:label="lab_us-gaap_SwaptionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Swaption [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SwaptionMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SwaptionMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SwaptionMember" xlink:to="lab_us-gaap_SwaptionMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_39b4cc60-c6e3-4dc2-931f-d6e4f808b9ea_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Financial Instruments Owned and Pledged as Collateral</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock"/>
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    <link:label id="lab_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_d43b754b-0795-4b18-a165-6e5df004c02f_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchase Program, Remaining Authorized Repurchase Amount</link:label>
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    <link:label id="lab_ecd_TrdArrTerminationDate_terseLabel_en-US" xlink:label="lab_ecd_TrdArrTerminationDate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Termination Date</link:label>
    <link:label id="lab_ecd_TrdArrTerminationDate_label_en-US" xlink:label="lab_ecd_TrdArrTerminationDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Arrangement Termination Date</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_TrdArrTerminationDate" xlink:to="lab_ecd_TrdArrTerminationDate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ChangeInAccountingPrincipleMember_822d532f-a8c5-48ee-887f-8d8a6ed9daec_terseLabel_en-US" xlink:label="lab_us-gaap_ChangeInAccountingPrincipleMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments for Change in Accounting Principle [Domain]</link:label>
    <link:label id="lab_us-gaap_ChangeInAccountingPrincipleMember_label_en-US" xlink:label="lab_us-gaap_ChangeInAccountingPrincipleMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in Accounting Principle, Type [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ChangeInAccountingPrincipleMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember" xlink:to="lab_us-gaap_ChangeInAccountingPrincipleMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockSharesAuthorized_8c890a7c-43dd-4950-8a2d-f3daadc3f85b_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesAuthorized_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesAuthorized" xlink:to="lab_us-gaap_CommonStockSharesAuthorized" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_f346a19f-c802-4e08-8514-4f736b8d0569_terseLabel_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Agency securities, at fair value, and other mortgage credit investments (including pledged securities of $253 and $605, respectively)</link:label>
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_50a2b09a-fa88-41ee-b508-ddb4c941d7dc_verboseLabel_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Agency Securities, at Fair Value</link:label>
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_label_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Agency Securities, at Fair Value</link:label>
    <link:label id="lab_agnc_NonAgencySecuritiesatFairValue_documentation_en-US" xlink:label="lab_agnc_NonAgencySecuritiesatFairValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Agency Securities, at Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue" xlink:href="agnc-20230930.xsd#agnc_NonAgencySecuritiesatFairValue"/>
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    <link:label id="lab_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock_ae5ca12b-05ac-4a70-b76b-c47f77de8843_terseLabel_en-US" xlink:label="lab_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Interest Rate Swap Agreement by Receive Index (as a percentage of Notional Amount) [Table Text Block]</link:label>
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    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_e21d7017-e988-4084-b275-0b5e1bb7bfc9_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total available-for-sale securities, at fair value</link:label>
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    <link:label id="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_9aac5dd8-6eaa-4c1d-8298-64acc532df6a_terseLabel_en-US" xlink:label="lab_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivable for investment securities sold (including pledged securities of $273 and $119, respectively)</link:label>
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    <link:label id="lab_agnc_PreferredStockGValueIssued_51c38435-089a-406b-bff3-ac5b3f1b797e_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockGValueIssued" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock G, Value, Issued</link:label>
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    <link:label id="lab_agnc_DerivativeInstrumentsDesignationDomain_9c7c2d10-075c-4875-a81d-c695859c3cf8_terseLabel_en-US" xlink:label="lab_agnc_DerivativeInstrumentsDesignationDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments Designation [Domain]</link:label>
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    <link:label id="lab_us-gaap_UnderlyingAssetClassDomain_db3fc2b9-b8cc-4ea8-8d8a-3f8175109049_terseLabel_en-US" xlink:label="lab_us-gaap_UnderlyingAssetClassDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment Securities Class [Domain]</link:label>
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    <link:label id="lab_us-gaap_DerivativeLineItems_f93e530d-77a1-45f5-90d1-5e045833298b_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative [Line Items]</link:label>
    <link:label id="lab_us-gaap_DerivativeLineItems_label_en-US" xlink:label="lab_us-gaap_DerivativeLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLineItems" xlink:to="lab_us-gaap_DerivativeLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardTmgDiscLineItems_label_en-US" xlink:label="lab_ecd_AwardTmgDiscLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing Disclosures [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgDiscLineItems" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardTmgDiscLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="lab_ecd_AwardTmgDiscLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockTableTextBlock_2f598031-5e8b-4260-98d6-96770ada0cc6_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock [Table Text Block]</link:label>
    <link:label id="lab_agnc_PreferredStockTableTextBlock_label_en-US" xlink:label="lab_agnc_PreferredStockTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock [Table Text Block]</link:label>
    <link:label id="lab_agnc_PreferredStockTableTextBlock_documentation_en-US" xlink:label="lab_agnc_PreferredStockTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Table Text Block] for Schedule of the company's preferred stock by series outstanding for the period(s) being reported.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_PreferredStockTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockTableTextBlock" xlink:to="lab_agnc_PreferredStockTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_TitleOfIndividualWithRelationshipToEntityDomain_b227a1dc-3197-4809-8fc3-a3f1e0ac2e87_terseLabel_en-US" xlink:label="lab_srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of Individual [Domain]</link:label>
    <link:label id="lab_srt_TitleOfIndividualWithRelationshipToEntityDomain_label_en-US" xlink:label="lab_srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of Individual [Domain]</link:label>
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    <link:label id="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_101939b7-38d7-4620-bffa-c0cd7ec7d364_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends payable</link:label>
    <link:label id="lab_us-gaap_DividendsPayableCurrentAndNoncurrent_label_en-US" xlink:label="lab_us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends Payable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:to="lab_us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A2.5CouponMember_c504d14e-f25e-468b-86aa-0983c36d8cb6_terseLabel_en-US" xlink:label="lab_agnc_A2.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A2.5CouponMember_label_en-US" xlink:label="lab_agnc_A2.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A2.5CouponMember_documentation_en-US" xlink:label="lab_agnc_A2.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2.5% Coupon [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A2.5CouponMember" xlink:href="agnc-20230930.xsd#agnc_A2.5CouponMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A2.5CouponMember" xlink:to="lab_agnc_A2.5CouponMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdditionalPaidInCapital_a5c68316-dcf8-4812-b90a-5600e86dc6c9_terseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional paid-in capital</link:label>
    <link:label id="lab_us-gaap_AdditionalPaidInCapital_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Paid in Capital</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapital" xlink:to="lab_us-gaap_AdditionalPaidInCapital" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_56361432-8f49-4782-bd7a-d1b3f2fa8241_terseLabel_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Amount</link:label>
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_label_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Amount After Deducting Gross Amounts Not Offset on the Balance Sheet From Net Amount of Assets (Liabilities) Presented on the Balance Sheet</link:label>
    <link:label id="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_documentation_en-US" xlink:label="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net amount after deducting gross amounts not offset on the balance sheet from net amount of assets (liabilities) presented on the balance sheet.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:href="agnc-20230930.xsd#agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:to="lab_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CreditRatingAxis_3e57484e-ea26-4be4-973c-24826f47d401_terseLabel_en-US" xlink:label="lab_agnc_CreditRatingAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Rating [Axis]</link:label>
    <link:label id="lab_agnc_CreditRatingAxis_label_en-US" xlink:label="lab_agnc_CreditRatingAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Rating [Axis]</link:label>
    <link:label id="lab_agnc_CreditRatingAxis_documentation_en-US" xlink:label="lab_agnc_CreditRatingAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Rating [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditRatingAxis" xlink:href="agnc-20230930.xsd#agnc_CreditRatingAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CreditRatingAxis" xlink:to="lab_agnc_CreditRatingAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_73b404ea-bc7e-402b-a781-40e399755c3e_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Outstanding Derivatives Not Designated as Hedging Instruments</link:label>
    <link:label id="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_label_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Outstanding Derivatives Not Designated as Hedging Instruments [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_documentation_en-US" xlink:label="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Outstanding Derivatives Not Designated as Hedging Instruments [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:to="lab_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockBLiquidationPreferenceValue_aae9d86b-52df-4e78-a291-1f0603f6173d_terseLabel_en-US" xlink:label="lab_agnc_PreferredStockBLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock B, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockBLiquidationPreferenceValue_label_en-US" xlink:label="lab_agnc_PreferredStockBLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock B, Liquidation Preference, Value</link:label>
    <link:label id="lab_agnc_PreferredStockBLiquidationPreferenceValue_documentation_en-US" xlink:label="lab_agnc_PreferredStockBLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Value of the difference between preference in liquidation and the par or stated values of the preferred B shares.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue" xlink:href="agnc-20230930.xsd#agnc_PreferredStockBLiquidationPreferenceValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockBLiquidationPreferenceValue" xlink:to="lab_agnc_PreferredStockBLiquidationPreferenceValue" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_52774644-7ba7-4443-8afe-603e38661269_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued interest on pledged securities</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available For Sale Securities Pledged As Collateral Accrued Interest</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:href="agnc-20230930.xsd#agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:to="lab_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_61e5f48e-598f-4234-9966-b117fc35f7b5_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative liabilities, at fair value [Member]</link:label>
    <link:label id="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_label_en-US" xlink:label="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Financial Instruments, Liabilities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:to="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_5b6e4806-7ba2-4bc9-9940-e6086ee064cf_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term Debt, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_ShortTermDebtTypeAxis_label_en-US" xlink:label="lab_us-gaap_ShortTermDebtTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-Term Debt, Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis" xlink:to="lab_us-gaap_ShortTermDebtTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_WeightedAverageForwardStartDate_25c514ab-436e-4349-b168-0e4ade726e9b_terseLabel_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Forward Start Date</link:label>
    <link:label id="lab_agnc_WeightedAverageForwardStartDate_label_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Forward Start Date</link:label>
    <link:label id="lab_agnc_WeightedAverageForwardStartDate_documentation_en-US" xlink:label="lab_agnc_WeightedAverageForwardStartDate" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Forward Start Date</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_WeightedAverageForwardStartDate" xlink:href="agnc-20230930.xsd#agnc_WeightedAverageForwardStartDate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_WeightedAverageForwardStartDate" xlink:to="lab_agnc_WeightedAverageForwardStartDate" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_InsiderTradingArrLineItems_label_en-US" xlink:label="lab_ecd_InsiderTradingArrLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Insider Trading Arrangements [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_InsiderTradingArrLineItems" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_InsiderTradingArrLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="lab_ecd_InsiderTradingArrLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PreferredStockDValueIssued_9ece42c2-ddc1-4c9b-9b65-91f154f3aea0_verboseLabel_en-US" xlink:label="lab_agnc_PreferredStockDValueIssued" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock D, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockDValueIssued_label_en-US" xlink:label="lab_agnc_PreferredStockDValueIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock D, Value, Issued</link:label>
    <link:label id="lab_agnc_PreferredStockDValueIssued_documentation_en-US" xlink:label="lab_agnc_PreferredStockDValueIssued" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate par or stated value of issued nonredeemable preferred D stock (or preferred stock D redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within stockholders' equity.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PreferredStockDValueIssued" xlink:href="agnc-20230930.xsd#agnc_PreferredStockDValueIssued"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_PreferredStockDValueIssued" xlink:to="lab_agnc_PreferredStockDValueIssued" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_7915291a-9c4e-490f-b1af-3b87421a237b_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Related Party [Axis]</link:label>
    <link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Related Party, Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityRegistrantName_61824b05-af8e-467f-baa3-804a3c364650_terseLabel_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:label id="lab_dei_EntityRegistrantName_label_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityRegistrantName" xlink:to="lab_dei_EntityRegistrantName" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_MtrlTermsOfTrdArrTextBlock_terseLabel_en-US" xlink:label="lab_ecd_MtrlTermsOfTrdArrTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Material Terms of Trading Arrangement</link:label>
    <link:label id="lab_ecd_MtrlTermsOfTrdArrTextBlock_label_en-US" xlink:label="lab_ecd_MtrlTermsOfTrdArrTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Material Terms of Trading Arrangement [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_MtrlTermsOfTrdArrTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_MtrlTermsOfTrdArrTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_MtrlTermsOfTrdArrTextBlock" xlink:to="lab_ecd_MtrlTermsOfTrdArrTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardTmgMethodTextBlock_terseLabel_en-US" xlink:label="lab_ecd_AwardTmgMethodTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing Method</link:label>
    <link:label id="lab_ecd_AwardTmgMethodTextBlock_label_en-US" xlink:label="lab_ecd_AwardTmgMethodTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Timing Method [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgMethodTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardTmgMethodTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AwardTmgMethodTextBlock" xlink:to="lab_ecd_AwardTmgMethodTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_e6554207-d3f4-4b7b-b229-19dbb6873418_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase in other assets</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Other Operating Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:to="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_OtherDerivativeAsset_a7e113d6-f712-4000-824c-e1a749ee1fe4_terseLabel_en-US" xlink:label="lab_agnc_OtherDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other derivative asset</link:label>
    <link:label id="lab_agnc_OtherDerivativeAsset_label_en-US" xlink:label="lab_agnc_OtherDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other derivative asset</link:label>
    <link:label id="lab_agnc_OtherDerivativeAsset_documentation_en-US" xlink:label="lab_agnc_OtherDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other derivative asset</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativeAsset" xlink:href="agnc-20230930.xsd#agnc_OtherDerivativeAsset"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherDerivativeAsset" xlink:to="lab_agnc_OtherDerivativeAsset" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_da4586e4-330a-4817-b251-f7f5240c35c2_terseLabel_en-US" xlink:label="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinuation of Election to Account for Interest Rate Swaps as Designated Cash Flow Hedges [Member]</link:label>
    <link:label id="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_label_en-US" xlink:label="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinuation of Election to Account for Interest Rate Swaps as Designated Cash Flow Hedges [Member]</link:label>
    <link:label id="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_documentation_en-US" xlink:label="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinuation of Election to Account for Interest Rate Swaps as Designated Cash Flow Hedges [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:href="agnc-20230930.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:to="lab_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AdjToCompAmt_terseLabel_en-US" xlink:label="lab_ecd_AdjToCompAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustment to Compensation, Amount</link:label>
    <link:label id="lab_ecd_AdjToCompAmt_label_en-US" xlink:label="lab_ecd_AdjToCompAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustment to Compensation Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AdjToCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AdjToCompAmt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AdjToCompAmt" xlink:to="lab_ecd_AdjToCompAmt" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_7490c4b9-0636-4d88-a991-bf65e9028a07_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Five Years and Less than or Equal to Seven Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_label_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Five Years and Less than or Equal to Seven Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_documentation_en-US" xlink:label="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Five Years and Less than or Equal to Seven Years [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:href="agnc-20230930.xsd#agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:to="lab_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_afd7c475-00e8-472e-abe7-ba06855df7ff_terseLabel_en-US" xlink:label="lab_agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Gain &amp; Loss of Investment Securities [Member]</link:label>
    <link:label id="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_label_en-US" xlink:label="lab_agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Gain &amp; Loss of Investment Securities [Member]</link:label>
    <link:label id="lab_agnc_GrossGainLossofInvestmentSecuritiesMember_documentation_en-US" xlink:label="lab_agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Gain &amp; Loss of Investment Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:href="agnc-20230930.xsd#agnc_GrossGainLossofInvestmentSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:to="lab_agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_AuditorName_eaac814c-170e-4524-8a6a-83c6537de3fd_terseLabel_en-US" xlink:label="lab_dei_AuditorName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Auditor Name</link:label>
    <link:label id="lab_dei_AuditorName_label_en-US" xlink:label="lab_dei_AuditorName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Auditor Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AuditorName" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AuditorName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AuditorName" xlink:to="lab_dei_AuditorName" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_CompActuallyPaidVsNetIncomeTextBlock_terseLabel_en-US" xlink:label="lab_ecd_CompActuallyPaidVsNetIncomeTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Net Income</link:label>
    <link:label id="lab_ecd_CompActuallyPaidVsNetIncomeTextBlock_label_en-US" xlink:label="lab_ecd_CompActuallyPaidVsNetIncomeTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation Actually Paid vs. Net Income [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsNetIncomeTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_CompActuallyPaidVsNetIncomeTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_CompActuallyPaidVsNetIncomeTextBlock" xlink:to="lab_ecd_CompActuallyPaidVsNetIncomeTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis_a587029e-2ec5-4a59-a5ca-49b2ae60b2d0_terseLabel_en-US" xlink:label="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis_label_en-US" xlink:label="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:to="lab_us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_PeerGroupIssuersFnTextBlock_terseLabel_en-US" xlink:label="lab_ecd_PeerGroupIssuersFnTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Peer Group Issuers, Footnote</link:label>
    <link:label id="lab_ecd_PeerGroupIssuersFnTextBlock_label_en-US" xlink:label="lab_ecd_PeerGroupIssuersFnTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Peer Group Issuers, Footnote [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeerGroupIssuersFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_PeerGroupIssuersFnTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_PeerGroupIssuersFnTextBlock" xlink:to="lab_ecd_PeerGroupIssuersFnTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PreferredStockDividendRatePercentage_015d0b6c-543c-48b7-9d02-929820b0d9dd_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividend Rate, Percentage</link:label>
    <link:label id="lab_us-gaap_PreferredStockDividendRatePercentage_label_en-US" xlink:label="lab_us-gaap_PreferredStockDividendRatePercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Dividend Rate, Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockDividendRatePercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendRatePercentage" xlink:to="lab_us-gaap_PreferredStockDividendRatePercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_755e69a8-a874-402f-9222-f6d5845f23b6_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis</link:label>
    <link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_OtherDerivativesMember_f59163bf-aff9-4576-bb17-0bd14b1637f5_terseLabel_en-US" xlink:label="lab_agnc_OtherDerivativesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Derivatives [Member]</link:label>
    <link:label id="lab_agnc_OtherDerivativesMember_cc05a44f-81b9-4ed6-875e-20d5885a5de8_verboseLabel_en-US" xlink:label="lab_agnc_OtherDerivativesMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other derivative instruments [Member]</link:label>
    <link:label id="lab_agnc_OtherDerivativesMember_label_en-US" xlink:label="lab_agnc_OtherDerivativesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Derivatives [Member]</link:label>
    <link:label id="lab_agnc_OtherDerivativesMember_documentation_en-US" xlink:label="lab_agnc_OtherDerivativesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Derivatives [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherDerivativesMember" xlink:href="agnc-20230930.xsd#agnc_OtherDerivativesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherDerivativesMember" xlink:to="lab_agnc_OtherDerivativesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueMember_5531cca6-e503-4865-bde5-f160350372da_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Remeasured at Fair Value [Member]</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueMember_label_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Remeasured at Fair Value [Member]</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueMember_documentation_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember" xlink:href="agnc-20230930.xsd#agnc_SecuritiesRemeasuredatFairValueMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesRemeasuredatFairValueMember" xlink:to="lab_agnc_SecuritiesRemeasuredatFairValueMember" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityCentralIndexKey_d7148097-ecf1-44af-be3c-135080c836ed_terseLabel_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:label id="lab_dei_EntityCentralIndexKey_label_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCentralIndexKey" xlink:to="lab_dei_EntityCentralIndexKey" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_OtherAssetsOther_d42477fb-97ce-4292-9cfc-5e7bbc027a65_terseLabel_en-US" xlink:label="lab_agnc_OtherAssetsOther" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets - Other</link:label>
    <link:label id="lab_agnc_OtherAssetsOther_label_en-US" xlink:label="lab_agnc_OtherAssetsOther" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets - Other</link:label>
    <link:label id="lab_agnc_OtherAssetsOther_documentation_en-US" xlink:label="lab_agnc_OtherAssetsOther" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets - Other</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsOther" xlink:href="agnc-20230930.xsd#agnc_OtherAssetsOther"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherAssetsOther" xlink:to="lab_agnc_OtherAssetsOther" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_NonRule10b51ArrTrmntdFlag_terseLabel_en-US" xlink:label="lab_ecd_NonRule10b51ArrTrmntdFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Rule 10b5-1 Arrangement Terminated</link:label>
    <link:label id="lab_ecd_NonRule10b51ArrTrmntdFlag_label_en-US" xlink:label="lab_ecd_NonRule10b51ArrTrmntdFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Rule 10b5-1 Arrangement Terminated [Flag]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonRule10b51ArrTrmntdFlag" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_NonRule10b51ArrTrmntdFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_NonRule10b51ArrTrmntdFlag" xlink:to="lab_ecd_NonRule10b51ArrTrmntdFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember_e26d3430-89c5-436d-a230-88fe856b9d18_terseLabel_en-US" xlink:label="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Three Years and Less Than or Equal to Four Years</link:label>
    <link:label id="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember_label_en-US" xlink:label="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Three Years and Less Than or Equal to Four Years [Member]</link:label>
    <link:label id="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember_documentation_en-US" xlink:label="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater Than Three Years and Less Than or Equal to Four Years Member</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" xlink:href="agnc-20230930.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" xlink:to="lab_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DividendsPreferredStockCash_1f0cf171-ee17-4ee7-afa3-57c09d4a8b97_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DividendsPreferredStockCash" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred dividends declared</link:label>
    <link:label id="lab_us-gaap_DividendsPreferredStockCash_2aa75cf7-a5ff-458b-a647-dfb7823462c9_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsPreferredStockCash" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends, Preferred Stock, Cash</link:label>
    <link:label id="lab_us-gaap_DividendsPreferredStockCash_label_en-US" xlink:label="lab_us-gaap_DividendsPreferredStockCash" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends, Preferred Stock, Cash</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPreferredStockCash" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsPreferredStockCash"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendsPreferredStockCash" xlink:to="lab_us-gaap_DividendsPreferredStockCash" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_TrdArrIndName_terseLabel_en-US" xlink:label="lab_ecd_TrdArrIndName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name</link:label>
    <link:label id="lab_ecd_TrdArrIndName_label_en-US" xlink:label="lab_ecd_TrdArrIndName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Arrangement, Individual Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrIndName" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_TrdArrIndName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_TrdArrIndName" xlink:to="lab_ecd_TrdArrIndName" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_TotalAgencySecurities_a21cc49a-d9dc-4b8c-a362-5307a636d7b6_terseLabel_en-US" xlink:label="lab_agnc_TotalAgencySecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total agency MBS, at fair value</link:label>
    <link:label id="lab_agnc_TotalAgencySecurities_label_en-US" xlink:label="lab_agnc_TotalAgencySecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Agency Securities</link:label>
    <link:label id="lab_agnc_TotalAgencySecurities_documentation_en-US" xlink:label="lab_agnc_TotalAgencySecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Represents total investment in agency securities at fair value.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TotalAgencySecurities" xlink:href="agnc-20230930.xsd#agnc_TotalAgencySecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TotalAgencySecurities" xlink:to="lab_agnc_TotalAgencySecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues_6e7ea782-a63a-44d0-924f-65f2fb0fa76b_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Issued During Period, Value, New Issues</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Issued During Period, Value, New Issues</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:to="lab_us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityDomain_18970c5c-d537-4592-83a0-0f94ddb214d4_terseLabel_en-US" xlink:label="lab_dei_EntityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity [Domain]</link:label>
    <link:label id="lab_dei_EntityDomain_label_en-US" xlink:label="lab_dei_EntityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityDomain" xlink:to="lab_dei_EntityDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_AmendmentFlag_5ea75f62-87de-4579-9507-fa6fbcd7c430_terseLabel_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amendment Flag</link:label>
    <link:label id="lab_dei_AmendmentFlag_label_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amendment Flag</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AmendmentFlag" xlink:to="lab_dei_AmendmentFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_LegalEntityAxis_d71cae59-267a-4de5-b530-9be02ee58bab_terseLabel_en-US" xlink:label="lab_dei_LegalEntityAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Legal Entity [Axis]</link:label>
    <link:label id="lab_dei_LegalEntityAxis_label_en-US" xlink:label="lab_dei_LegalEntityAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Legal Entity [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_LegalEntityAxis" xlink:to="lab_dei_LegalEntityAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueHedgingMember_8e7150cc-bd55-4d78-8130-45077d874907_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueHedgingMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Hedging [Member]</link:label>
    <link:label id="lab_us-gaap_FairValueHedgingMember_label_en-US" xlink:label="lab_us-gaap_FairValueHedgingMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Hedging [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueHedgingMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueHedgingMember" xlink:to="lab_us-gaap_FairValueHedgingMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_bdb612cc-1892-45a9-9c8d-6c5672aa642a_terseLabel_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Offsetting Assets and Liabilities [Line Items]</link:label>
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_label_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Offsetting Assets and Liabilities [Line Items]</link:label>
    <link:label id="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems_documentation_en-US" xlink:label="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Line Items] for Offsetting Assets and Liabilities [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:href="agnc-20230930.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:to="lab_agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InterestIncomeExpenseNet_b3f800ac-e2db-40e2-b2c7-c42d5901712e_terseLabel_en-US" xlink:label="lab_us-gaap_InterestIncomeExpenseNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net interest income</link:label>
    <link:label id="lab_us-gaap_InterestIncomeExpenseNet_label_en-US" xlink:label="lab_us-gaap_InterestIncomeExpenseNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Income (Expense), Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestIncomeExpenseNet" xlink:to="lab_us-gaap_InterestIncomeExpenseNet" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_69672c89-c656-48dd-a4f4-bbef495cbef5_terseLabel_en-US" xlink:label="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Principal collections on credit risk transfer and non-Agency securities</link:label>
    <link:label id="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_label_en-US" xlink:label="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Principal collections on credit risk transfer and non-Agency securities</link:label>
    <link:label id="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_documentation_en-US" xlink:label="lab_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Principal collections on CRT and non-Agency securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:href="agnc-20230930.xsd#agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities"/>
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    <link:label id="lab_agnc_DerivativeAgreementsAndOtherMember_documentation_en-US" xlink:label="lab_agnc_DerivativeAgreementsAndOtherMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Agreements and Other Agreements</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeAgreementsAndOtherMember" xlink:href="agnc-20230930.xsd#agnc_DerivativeAgreementsAndOtherMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeAgreementsAndOtherMember" xlink:to="lab_agnc_DerivativeAgreementsAndOtherMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GoodwillDisclosureTextBlock_e346c188-e62f-4c35-9515-12433e866492_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill Disclosure [Text Block]</link:label>
    <link:label id="lab_us-gaap_GoodwillDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_GoodwillDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillDisclosureTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillDisclosureTextBlock" xlink:to="lab_us-gaap_GoodwillDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ReceiverSwaptionMember_11ebdd81-62bb-41d8-8c87-773926d86e87_terseLabel_en-US" xlink:label="lab_agnc_ReceiverSwaptionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receiver Swaption [Member]</link:label>
    <link:label id="lab_agnc_ReceiverSwaptionMember_label_en-US" xlink:label="lab_agnc_ReceiverSwaptionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receiver Swaption [Member]</link:label>
    <link:label id="lab_agnc_ReceiverSwaptionMember_documentation_en-US" xlink:label="lab_agnc_ReceiverSwaptionMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receiver Swaption [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ReceiverSwaptionMember" xlink:href="agnc-20230930.xsd#agnc_ReceiverSwaptionMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ReceiverSwaptionMember" xlink:to="lab_agnc_ReceiverSwaptionMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_05e036ad-1023-496d-8a57-534ed5cd2394_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average number of common shares outstanding - diluted</link:label>
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    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Diluted</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:to="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_TradingSecuritiesMember_62def1d1-a4dd-4e8a-a206-93e0b4548589_terseLabel_en-US" xlink:label="lab_agnc_TradingSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Securities [Member]</link:label>
    <link:label id="lab_agnc_TradingSecuritiesMember_label_en-US" xlink:label="lab_agnc_TradingSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Securities [Member]</link:label>
    <link:label id="lab_agnc_TradingSecuritiesMember_documentation_en-US" xlink:label="lab_agnc_TradingSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in debt security remeasured at fair value through earnings (trading securities)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_TradingSecuritiesMember" xlink:href="agnc-20230930.xsd#agnc_TradingSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_TradingSecuritiesMember" xlink:to="lab_agnc_TradingSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CashPledgedFromCounterparties_715adece-6f26-4e9e-80e5-6cb66936a0d4_terseLabel_en-US" xlink:label="lab_agnc_CashPledgedFromCounterparties" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Pledged From Counterparties</link:label>
    <link:label id="lab_agnc_CashPledgedFromCounterparties_label_en-US" xlink:label="lab_agnc_CashPledgedFromCounterparties" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Pledged From Counterparties</link:label>
    <link:label id="lab_agnc_CashPledgedFromCounterparties_documentation_en-US" xlink:label="lab_agnc_CashPledgedFromCounterparties" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Pledged From Counterparties</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CashPledgedFromCounterparties" xlink:href="agnc-20230930.xsd#agnc_CashPledgedFromCounterparties"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CashPledgedFromCounterparties" xlink:to="lab_agnc_CashPledgedFromCounterparties" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock_terseLabel_en-US" xlink:label="lab_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forgone Recovery, Explanation of Impracticability</link:label>
    <link:label id="lab_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock_label_en-US" xlink:label="lab_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forgone Recovery, Explanation of Impracticability [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock" xlink:to="lab_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_bce0dc3f-84e8-405b-80f0-3399272734fb_terseLabel_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Yield</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_label_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available For Sale Securities Weighted Average Life yield</link:label>
    <link:label id="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_documentation_en-US" xlink:label="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available For Sale Securities Weighted Average Life yield</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:href="agnc-20230930.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:to="lab_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_013dc046-4ad3-476f-bedd-0ba95ded312c_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Realized Loss</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Realized Loss</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss" xlink:to="lab_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_CoSelectedMeasureAmt_terseLabel_en-US" xlink:label="lab_ecd_CoSelectedMeasureAmt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Company Selected Measure Amount</link:label>
    <link:label id="lab_ecd_CoSelectedMeasureAmt_label_en-US" xlink:label="lab_ecd_CoSelectedMeasureAmt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Company Selected Measure Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CoSelectedMeasureAmt" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_CoSelectedMeasureAmt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_CoSelectedMeasureAmt" xlink:to="lab_ecd_CoSelectedMeasureAmt" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_A4555CouponsMember_be89056e-13b9-413d-b4f7-111f10867442_terseLabel_en-US" xlink:label="lab_agnc_A4555CouponsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.5% - 5.5% Coupons</link:label>
    <link:label id="lab_agnc_A4555CouponsMember_label_en-US" xlink:label="lab_agnc_A4555CouponsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.5% - 5.5% Coupons [Member]</link:label>
    <link:label id="lab_agnc_A4555CouponsMember_documentation_en-US" xlink:label="lab_agnc_A4555CouponsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.5% - 5.5% Coupons</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_A4555CouponsMember" xlink:href="agnc-20230930.xsd#agnc_A4555CouponsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4555CouponsMember" xlink:to="lab_agnc_A4555CouponsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_Assets_34cb1b54-6a2d-4f90-942c-cdeabf772a98_totalLabel_en-US" xlink:label="lab_us-gaap_Assets" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total assets</link:label>
    <link:label id="lab_us-gaap_Assets_label_en-US" xlink:label="lab_us-gaap_Assets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets" xlink:to="lab_us-gaap_Assets" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AwardsCloseToMnpiDiscIndName_terseLabel_en-US" xlink:label="lab_ecd_AwardsCloseToMnpiDiscIndName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name</link:label>
    <link:label id="lab_ecd_AwardsCloseToMnpiDiscIndName_label_en-US" xlink:label="lab_ecd_AwardsCloseToMnpiDiscIndName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Awards Close in Time to MNPI Disclosures, Individual Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardsCloseToMnpiDiscIndName" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AwardsCloseToMnpiDiscIndName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AwardsCloseToMnpiDiscIndName" xlink:to="lab_ecd_AwardsCloseToMnpiDiscIndName" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock_c77256c8-1027-419b-abe0-9cd310d68e72_terseLabel_en-US" xlink:label="lab_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Tax Treatment of Distributions Per Share</link:label>
    <link:label id="lab_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock_label_en-US" xlink:label="lab_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Tax Treatment of Distributions Per Share [Table Text Block]</link:label>
    <link:label id="lab_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock_documentation_en-US" xlink:label="lab_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Tax Treatment of Distributions Per Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" xlink:href="agnc-20230930.xsd#agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" xlink:to="lab_agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareRepurchaseProgramAxis_e7673a91-aed4-4871-8d1d-71994be1112b_terseLabel_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Plan Name [Axis]</link:label>
    <link:label id="lab_us-gaap_ShareRepurchaseProgramAxis_label_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share Repurchase Program [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis" xlink:to="lab_us-gaap_ShareRepurchaseProgramAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedPremium_ced957e7-8d42-4a94-b1be-a6fd2421c324_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unamortized premium</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedPremium_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Unamortized Premium</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentUnamortizedPremium"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedPremium" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedPremium" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_dfa204c9-35a4-4638-82cf-4d5297a1a5c5_terseLabel_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Debt Securities</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_label_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Remeasured at Fair Value Through Earnings, Debt Securities</link:label>
    <link:label id="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_documentation_en-US" xlink:label="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount of debt securities remeasured at fair value through earnings.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:href="agnc-20230930.xsd#agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:to="lab_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LaborAndRelatedExpense_b3ceb277-c41c-4e2b-ab21-c4c24dc9bf90_terseLabel_en-US" xlink:label="lab_us-gaap_LaborAndRelatedExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Labor and Related Expense</link:label>
    <link:label id="lab_us-gaap_LaborAndRelatedExpense_label_en-US" xlink:label="lab_us-gaap_LaborAndRelatedExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Labor and Related Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LaborAndRelatedExpense" xlink:to="lab_us-gaap_LaborAndRelatedExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_193f6445-b2cb-42a2-a3a0-02aa03f0e9de_terseLabel_en-US" xlink:label="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Risk Of Repurchase Agreement To Stockholders Equity</link:label>
    <link:label id="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_label_en-US" xlink:label="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Risk Of Repurchase Agreement To Stockholders Equity</link:label>
    <link:label id="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_documentation_en-US" xlink:label="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Risk Of Repurchase Agreement To Stockholders Equity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:href="agnc-20230930.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:to="lab_agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SeriesAPreferredStockMember_56549141-7c96-401d-9398-44d7aa2f7ed6_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series A Preferred Stock [Member]</link:label>
    <link:label id="lab_us-gaap_SeriesAPreferredStockMember_label_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series A Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesAPreferredStockMember" xlink:to="lab_us-gaap_SeriesAPreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_218a0cf8-ea76-43df-88d7-f4a489a60881_terseLabel_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 6.875% Series D Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_label_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 6.875% Series D Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:label id="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_documentation_en-US" xlink:label="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depository shares each representing a 1/1,000th interest in a share of 6.875% Series D Fixed-to-Floating Rate Cumulative Redeemable Preferred Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:href="agnc-20230930.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:to="lab_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ScheduleofDividendsDeclaredAbstract_0e6ad56c-e7dc-456d-b98f-dcb07bd89246_terseLabel_en-US" xlink:label="lab_agnc_ScheduleofDividendsDeclaredAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Dividends Declared [Abstract]</link:label>
    <link:label id="lab_agnc_ScheduleofDividendsDeclaredAbstract_label_en-US" xlink:label="lab_agnc_ScheduleofDividendsDeclaredAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Dividends Declared [Abstract]</link:label>
    <link:label id="lab_agnc_ScheduleofDividendsDeclaredAbstract_documentation_en-US" xlink:label="lab_agnc_ScheduleofDividendsDeclaredAbstract" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Dividends Declared [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ScheduleofDividendsDeclaredAbstract" xlink:href="agnc-20230930.xsd#agnc_ScheduleofDividendsDeclaredAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ScheduleofDividendsDeclaredAbstract" xlink:to="lab_agnc_ScheduleofDividendsDeclaredAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MaturityOvernightMember_17b6fc24-8b83-42e8-adee-cb117dcc61c7_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityOvernightMember_label_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityOvernightMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MaturityOvernightMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityOvernightMember" xlink:to="lab_us-gaap_MaturityOvernightMember" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_NonNeosMember_terseLabel_en-US" xlink:label="lab_ecd_NonNeosMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-NEOs</link:label>
    <link:label id="lab_ecd_NonNeosMember_label_en-US" xlink:label="lab_ecd_NonNeosMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-NEOs [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonNeosMember" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_NonNeosMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_NonNeosMember" xlink:to="lab_ecd_NonNeosMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_235f3d8d-9bff-42fb-a74f-ba8cf511932f_terseLabel_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative By Maturity Years [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_label_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative By Maturity Years [Domain]</link:label>
    <link:label id="lab_agnc_DerivativeByMaturityYearsDomain_documentation_en-US" xlink:label="lab_agnc_DerivativeByMaturityYearsDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Domain] for Derivative By Maturity Years [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_DerivativeByMaturityYearsDomain" xlink:href="agnc-20230930.xsd#agnc_DerivativeByMaturityYearsDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain" xlink:to="lab_agnc_DerivativeByMaturityYearsDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_f24d3567-2789-4e3b-aa80-f678189b4c71_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing activities:</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Financing Activities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_OtherAssetsLineItems_ccf38795-0590-469f-9262-ee6160467645_terseLabel_en-US" xlink:label="lab_agnc_OtherAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets [Line Items]</link:label>
    <link:label id="lab_agnc_OtherAssetsLineItems_label_en-US" xlink:label="lab_agnc_OtherAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets [Line Items]</link:label>
    <link:label id="lab_agnc_OtherAssetsLineItems_documentation_en-US" xlink:label="lab_agnc_OtherAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_OtherAssetsLineItems" xlink:href="agnc-20230930.xsd#agnc_OtherAssetsLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_OtherAssetsLineItems" xlink:to="lab_agnc_OtherAssetsLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_a9672a66-4b8d-4217-ad69-6bfa92450446_terseLabel_en-US" xlink:label="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disclosure of Repurchase Agreements [Abstract]</link:label>
    <link:label id="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_label_en-US" xlink:label="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disclosure of Repurchase Agreements [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:to="lab_us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_NonPeoNeoMember_terseLabel_en-US" xlink:label="lab_ecd_NonPeoNeoMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-PEO NEO</link:label>
    <link:label id="lab_ecd_NonPeoNeoMember_label_en-US" xlink:label="lab_ecd_NonPeoNeoMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-PEO NEO [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonPeoNeoMember" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_NonPeoNeoMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_NonPeoNeoMember" xlink:to="lab_ecd_NonPeoNeoMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_77d026f4-d769-4807-a5cd-77b277bb8dfd_terseLabel_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage-backed Securities Available-for-sale, Fair Value Disclosure</link:label>
    <link:label id="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_label_en-US" xlink:label="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Security, Mortgage-Backed, Available-for-Sale, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:to="lab_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:type="arc" order="1"/>
    <link:label id="lab_ecd_AdjToCompAxis_terseLabel_en-US" xlink:label="lab_ecd_AdjToCompAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustment to Compensation:</link:label>
    <link:label id="lab_ecd_AdjToCompAxis_label_en-US" xlink:label="lab_ecd_AdjToCompAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustment to Compensation [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AdjToCompAxis" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AdjToCompAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_AdjToCompAxis" xlink:to="lab_ecd_AdjToCompAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_InterestRateSwapsLinkedto3MonthLIBOR_1dfb9f1b-1b7e-45d0-8f7f-1052c505b9bb_terseLabel_en-US" xlink:label="lab_agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Swaps Linked to 3-Month LIBOR</link:label>
    <link:label id="lab_agnc_InterestRateSwapsLinkedto3MonthLIBOR_label_en-US" xlink:label="lab_agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Swaps Linked to 3-Month LIBOR</link:label>
    <link:label id="lab_agnc_InterestRateSwapsLinkedto3MonthLIBOR_documentation_en-US" xlink:label="lab_agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">The percentage Interest Rate Swaps Linked to 3-Month LIBOR in the portfolio.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:href="agnc-20230930.xsd#agnc_InterestRateSwapsLinkedto3MonthLIBOR"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:to="lab_agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:type="arc" order="1"/>
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    <link:label id="lab_agnc_A7to9monthsMember_label_en-US" xlink:label="lab_agnc_A7to9monthsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">7 to 9 months [Member]</link:label>
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    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_09803dd4-1020-4502-bae7-56df36894f95_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average number of common shares outstanding - basic</link:label>
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    <link:label id="lab_srt_StatementScenarioAxis_label_en-US" xlink:label="lab_srt_StatementScenarioAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Scenario [Axis]</link:label>
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    <link:label id="lab_agnc_LongTermCapitalGainDividendPerShare_58bcc66c-4a4e-453c-b6a8-7ee73e94c429_terseLabel_en-US" xlink:label="lab_agnc_LongTermCapitalGainDividendPerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-Term Capital Gain Dividend Per Share</link:label>
    <link:label id="lab_agnc_LongTermCapitalGainDividendPerShare_label_en-US" xlink:label="lab_agnc_LongTermCapitalGainDividendPerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-Term Capital Gain Dividend Per Share</link:label>
    <link:label id="lab_agnc_LongTermCapitalGainDividendPerShare_documentation_en-US" xlink:label="lab_agnc_LongTermCapitalGainDividendPerShare" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-Term Capital Gain Dividend Per Share For Tax Purposes</link:label>
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    <link:label id="lab_agnc_A4.5CouponMember_a86957af-0c63-46f8-8c61-01f79c4c0414_terseLabel_en-US" xlink:label="lab_agnc_A4.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.5CouponMember_label_en-US" xlink:label="lab_agnc_A4.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.5% Coupon [Member]</link:label>
    <link:label id="lab_agnc_A4.5CouponMember_documentation_en-US" xlink:label="lab_agnc_A4.5CouponMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">4.5% Coupon [Member]</link:label>
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    <link:label id="lab_us-gaap_ScheduleOfShortTermDebtTable_e7cb706f-27e0-4492-a020-5121a93ae656_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfShortTermDebtTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Short-term Debt [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfShortTermDebtTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShortTermDebtTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Short-Term Debt [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShortTermDebtTable"/>
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    <link:label id="lab_us-gaap_LongMember_c167f0e9-dea7-4e75-a6ee-9a9f0cdc8364_terseLabel_en-US" xlink:label="lab_us-gaap_LongMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long [Member]</link:label>
    <link:label id="lab_us-gaap_LongMember_label_en-US" xlink:label="lab_us-gaap_LongMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongMember" xlink:to="lab_us-gaap_LongMember" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_5315afc6-6e26-4327-927b-c8582a43194c_terseLabel_en-US" xlink:label="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Changes in Derivative and Other Hedge Portfolio [Roll Forward]</link:label>
    <link:label id="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_label_en-US" xlink:label="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Changes in Derivative and Other Hedge Portfolio [Roll Forward]</link:label>
    <link:label id="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_documentation_en-US" xlink:label="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Changes in Derivative and Other Hedge Portfolio [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:href="agnc-20230930.xsd#agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:to="lab_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_agnc_CreditDefaultSwaps_4a96c050-1515-4114-ad91-a517ac05376d_terseLabel_en-US" xlink:label="lab_agnc_CreditDefaultSwaps" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Default Swaps</link:label>
    <link:label id="lab_agnc_CreditDefaultSwaps_label_en-US" xlink:label="lab_agnc_CreditDefaultSwaps" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Default Swaps</link:label>
    <link:label id="lab_agnc_CreditDefaultSwaps_documentation_en-US" xlink:label="lab_agnc_CreditDefaultSwaps" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Centrally cleared Credit Default Swaps (CDS) that reference the Markit CDX Investment Grade Index.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_agnc_CreditDefaultSwaps" xlink:href="agnc-20230930.xsd#agnc_CreditDefaultSwaps"/>
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    <link:label id="lab_ecd_PvpTable_terseLabel_en-US" xlink:label="lab_ecd_PvpTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pay vs Performance Disclosure</link:label>
    <link:label id="lab_ecd_PvpTable_label_en-US" xlink:label="lab_ecd_PvpTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pay vs Performance Disclosure [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PvpTable" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_PvpTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ecd_PvpTable" xlink:to="lab_ecd_PvpTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementLineItems_b01fb0fd-3b0f-4a60-bf83-692b182d7f74_terseLabel_en-US" xlink:label="lab_us-gaap_StatementLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Line Items]</link:label>
    <link:label id="lab_us-gaap_StatementLineItems_label_en-US" xlink:label="lab_us-gaap_StatementLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
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