<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with WebFilings-->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:href="agnc-20140331.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:href="agnc-20140331.xsd#ConsolidatedBalanceSheetsParentheticals" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:href="agnc-20140331.xsd#ConsolidatedStatementOfStockholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="agnc-20140331.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:href="agnc-20140331.xsd#ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstruments" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnIncomeStatementDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnIncomeStatementDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfForwardContractsDesignatedAsHedgesDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsEffectOfForwardContractsDesignatedAsHedgesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfInterestRateSwapsDesignatedAsHedgesDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsEffectOfInterestRateSwapsDesignatedAsHedgesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfDerivativesOutstandingNotDesignatedAsHedgingInstrumentsDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfDerivativesOutstandingNotDesignatedAsHedgingInstrumentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfLongAndShortPositionOfDerivativeInstrumentsDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfLongAndShortPositionOfDerivativeInstrumentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingForwardContractsDesignatedAsHedgingInstrumentsDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingForwardContractsDesignatedAsHedgingInstrumentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsAgreementsDesignatedAsHedgesInFutureDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsAgreementsDesignatedAsHedgesInFutureDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsAgreementsNotDesignatedAsHedgesDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsAgreementsNotDesignatedAsHedgesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDesignatedAsHedgingInstrumentsDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDesignatedAsHedgingInstrumentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingTbasDetails" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingTbasDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:href="agnc-20140331.xsd#DerivativeAndOtherHedgingInstrumentsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:href="agnc-20140331.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/FairValueMeasurements" xlink:href="agnc-20140331.xsd#FairValueMeasurements" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:href="agnc-20140331.xsd#FairValueMeasurementsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:href="agnc-20140331.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/IncomeTaxes" xlink:href="agnc-20140331.xsd#IncomeTaxes" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/IncomeTaxesDetails" xlink:href="agnc-20140331.xsd#IncomeTaxesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/IncomeTaxesTables" xlink:href="agnc-20140331.xsd#IncomeTaxesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecurities" xlink:href="agnc-20140331.xsd#InvestmentSecurities" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:href="agnc-20140331.xsd#InvestmentSecuritiesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/ManagementAgreementAndRelatedPartyTransactionsDetails" xlink:href="agnc-20140331.xsd#ManagementAgreementAndRelatedPartyTransactionsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/ManagementAgreementAndRelatedPartyTransactionsNotes" xlink:href="agnc-20140331.xsd#ManagementAgreementAndRelatedPartyTransactionsNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/ManagementAgreementAndRelatedPartyTransactionsTables" xlink:href="agnc-20140331.xsd#ManagementAgreementAndRelatedPartyTransactionsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/Organization" xlink:href="agnc-20140331.xsd#Organization" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/OrganizationDetails" xlink:href="agnc-20140331.xsd#OrganizationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/PledgedAssetsDetails" xlink:href="agnc-20140331.xsd#PledgedAssetsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/PledgedAssetsNotes" xlink:href="agnc-20140331.xsd#PledgedAssetsNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/PledgedAssetsPledgedAssetsDetails" xlink:href="agnc-20140331.xsd#PledgedAssetsPledgedAssetsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/PledgedAssetsTables" xlink:href="agnc-20140331.xsd#PledgedAssetsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebt" xlink:href="agnc-20140331.xsd#RepurchaseAgreementsAndOtherDebt" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtNarrativeDetails" xlink:href="agnc-20140331.xsd#RepurchaseAgreementsAndOtherDebtNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseAgreementsPolicies" xlink:href="agnc-20140331.xsd#RepurchaseAgreementsAndOtherDebtRepurchaseAgreementsPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:href="agnc-20140331.xsd#RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtTables" xlink:href="agnc-20140331.xsd#RepurchaseAgreementsAndOtherDebtTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/StockholdersEquity" xlink:href="agnc-20140331.xsd#StockholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/StockholdersEquityDetails" xlink:href="agnc-20140331.xsd#StockholdersEquityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/StockholdersEquityEquityOfferingsTables" xlink:href="agnc-20140331.xsd#StockholdersEquityEquityOfferingsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/StockholdersEquitySummaryOfFollowOnPublicOfferingsOfCommonStockDetails" xlink:href="agnc-20140331.xsd#StockholdersEquitySummaryOfFollowOnPublicOfferingsOfCommonStockDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/SubsequentEventDetails" xlink:href="agnc-20140331.xsd#SubsequentEventDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/SubsequentEventNotes" xlink:href="agnc-20140331.xsd#SubsequentEventNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/SubsequentEventTables" xlink:href="agnc-20140331.xsd#SubsequentEventTables" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="agnc-20140331.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="agnc-20140331.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:href="agnc-20140331.xsd#SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="simple" />
  <roleRef roleURI="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:href="agnc-20140331.xsd#UnauditedInterimConsolidatedFinancialStatements" xlink:type="simple" />
  <calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_6e1ed1d0-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_6e1ed1d0-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_a9ff4b94-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_a9ff4b94-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PayablesToBrokerDealersAndClearingOrganizations" xlink:label="loc_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_88e4c290-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PayablesToBrokerDealersAndClearingOrganizations_88e4c290-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_32d9963c-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_DerivativeLiabilities_32d9963c-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_3d5b31ba-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_3d5b31ba-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_be66baa7-0d54-05a7-1597-cb38e9805968" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_be66baa7-0d54-05a7-1597-cb38e9805968" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_055e365e-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_055e365e-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_851afc92-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6e59ec02-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_OtherLongTermDebt_851afc92-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_adc32df4-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_6e1ed1d0-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_StockholdersEquity_adc32df4-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_062fd1c8-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_adc32df4-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_062fd1c8-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_06e972fe-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_adc32df4-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AdditionalPaidInCapital_06e972fe-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_1e2a510e-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_adc32df4-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_CommonStockValue_1e2a510e-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_8fab7cfe-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_adc32df4-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PreferredStockValue_8fab7cfe-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a33a731a-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_adc32df4-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a33a731a-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_53566b24-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_53566b24-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_18320242-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_18320242-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_a1a8c880-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_a1a8c880-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_33cdaf24-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_DerivativeAssets_33cdaf24-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ReceivablesFromBrokersDealersAndClearingOrganizations" xlink:label="loc_us-gaap_ReceivablesFromBrokersDealersAndClearingOrganizations_98824d58-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ReceivablesFromBrokersDealersAndClearingOrganizations_98824d58-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_0e9d5f14-2b51-34a0-9a1e-cb38ef694e7d" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_0e9d5f14-2b51-34a0-9a1e-cb38ef694e7d" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherAssets" xlink:label="loc_us-gaap_OtherAssets_839ac38e-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_OtherAssets_839ac38e-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_5355c61a-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_5355c61a-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_b69ddc12-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="9" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_b69ddc12-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MarketableSecuritiesEquitySecurities" xlink:label="loc_us-gaap_MarketableSecuritiesEquitySecurities_78bd1cbe-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="10" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0ce13e30-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_MarketableSecuritiesEquitySecurities_78bd1cbe-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_181e990a-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_181e990a-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_05965354-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_05965354-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOciIntoIncomeEffectivePortionNetDeDesignatedInterestRateSwaps" xlink:label="loc_agnc_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOciIntoIncomeEffectivePortionNetDeDesignatedInterestRateSwaps_06fd0881-5eca-1c5f-a52c-cb38e985d330" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOciIntoIncomeEffectivePortionNetDeDesignatedInterestRateSwaps_06fd0881-5eca-1c5f-a52c-cb38e985d330" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_59d56644-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_59d56644-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_cef62608-d8af-73f9-b3c7-cb38f1f61f9e" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_cef62608-d8af-73f9-b3c7-cb38f1f61f9e" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_63a56200-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_63a56200-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_63119b74-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_63119b74-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_0c2b0700-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_0c2b0700-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_7cc2c354-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7cb5e5da-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_NetIncomeLoss_7cc2c354-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_181e990a-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_8aadd2ce-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_8aadd2ce-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_8abf9c0c-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_8abf9c0c-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_931d2338-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_931d2338-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_0eac527f-9a11-e61d-5ae4-cb38ec50b80a" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_0eac527f-9a11-e61d-5ae4-cb38ec50b80a" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_8acf055c-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_8acf055c-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_932ceed0-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_932ceed0-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:label="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_92541ea2-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_92541ea2-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_8953ead0-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="8" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_8953ead0-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8ac0ed78-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="9" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8ac0ed78-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_931f38d0-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="10" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_931f38d0-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInRestrictedCash" xlink:label="loc_us-gaap_IncreaseDecreaseInRestrictedCash_63cd9f36-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="11" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7c8e1730-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_IncreaseDecreaseInRestrictedCash_63cd9f36-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_181e990a-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_9313f8c6-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_9313f8c6-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_a1081034-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_a1081034-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromOtherDebt" xlink:label="loc_us-gaap_ProceedsFromOtherDebt_92d3965a-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromOtherDebt_92d3965a-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepaymentsOfOtherDebt" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_a10a3422-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="4" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_a10a3422-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_92d76e10-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_92d76e10-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_92ead8b0-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_92ead8b0-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_8932a1c2-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="7" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_8932a1c2-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_8b6e04d6-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="8" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7ca2b500-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_PaymentsOfDividends_8b6e04d6-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestIncomeExpenseNet" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_67eab6b2-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_69077e22-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_67eab6b2-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_69077e22-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_678fa826-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_67eab6b2-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_InterestExpense_678fa826-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_800dbf32-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_5b9b5a38-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_800dbf32-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_5b9b5a38-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ManagementFeeExpense" xlink:label="loc_us-gaap_ManagementFeeExpense_7896b204-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_800dbf32-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_ManagementFeeExpense_7896b204-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NoninterestIncome" xlink:label="loc_us-gaap_NoninterestIncome_7d65ea5c-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="agnc-20140331.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_76235e38-5df1-11e3-b035-22000a1e8102" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_7d65ea5c-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_76235e38-5df1-11e3-b035-22000a1e8102" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_59d56644-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_7d65ea5c-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_59d56644-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_a4243ad8-422a-62f5-c0d7-cb38f406e2b2" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_20119e50-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_a4243ad8-422a-62f5-c0d7-cb38f406e2b2" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_20119e50-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_7cc2c354-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_20119e50-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_NetIncomeLoss_7cc2c354-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_602ea2e4-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_7cc2c354-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_602ea2e4-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_ExciseAndReitIncomeTax" xlink:label="loc_agnc_ExciseAndReitIncomeTax_0eaaef66-9c76-932c-3519-cb38f6ee0203" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_7cc2c354-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_ExciseAndReitIncomeTax_0eaaef66-9c76-932c-3519-cb38f6ee0203" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_881fa96a-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_20119e50-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_881fa96a-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_84b6d7b2-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_881fa96a-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_84b6d7b2-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_84c04d06-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_881fa96a-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_84c04d06-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_8fce9194-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_a4243ad8-422a-62f5-c0d7-cb38f406e2b2" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_8fce9194-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnIncomeStatementDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfForwardContractsDesignatedAsHedgesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfInterestRateSwapsDesignatedAsHedgesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfDerivativesOutstandingNotDesignatedAsHedgingInstrumentsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfLongAndShortPositionOfDerivativeInstrumentsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingForwardContractsDesignatedAsHedgingInstrumentsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsAgreementsDesignatedAsHedgesInFutureDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsAgreementsNotDesignatedAsHedgesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDesignatedAsHedgingInstrumentsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingTbasDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurements" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/IncomeTaxes" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/IncomeTaxesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/IncomeTaxesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecurities" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="extended">
    <loc xlink:href="agnc-20140331.xsd#agnc_TotalAgencySecurities" xlink:label="loc_agnc_TotalAgencySecurities_8121d8cb-747d-815f-0695-cb38ec59bd7c" xlink:type="locator" />
    <loc xlink:href="agnc-20140331.xsd#agnc_AgencySecuritiesAmortizedCost" xlink:label="loc_agnc_AgencySecuritiesAmortizedCost_c9c3145b-962d-0925-f0f6-cb38f9302774" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_TotalAgencySecurities_8121d8cb-747d-815f-0695-cb38ec59bd7c" xlink:to="loc_agnc_AgencySecuritiesAmortizedCost_c9c3145b-962d-0925-f0f6-cb38f9302774" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_AgencySecuritiesGrossUnrealizedGain" xlink:label="loc_agnc_AgencySecuritiesGrossUnrealizedGain_9bb5b9ae-3bbc-52f9-5b80-cb38ede50e4d" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_TotalAgencySecurities_8121d8cb-747d-815f-0695-cb38ec59bd7c" xlink:to="loc_agnc_AgencySecuritiesGrossUnrealizedGain_9bb5b9ae-3bbc-52f9-5b80-cb38ede50e4d" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_AgencySecuritiesGrossUnrealizedLoss" xlink:label="loc_agnc_AgencySecuritiesGrossUnrealizedLoss_e37acac6-5dc8-11e3-b035-22000a1e8102" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_TotalAgencySecurities_8121d8cb-747d-815f-0695-cb38ec59bd7c" xlink:to="loc_agnc_AgencySecuritiesGrossUnrealizedLoss_e37acac6-5dc8-11e3-b035-22000a1e8102" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_0dd71b84-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_0d9c2e48-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_0dd71b84-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_0d9c2e48-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_0dce0f3a-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_0dd71b84-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_0dce0f3a-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_0dc618ca-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_0da80f2e-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_0dc618ca-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses_0da80f2e-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_0dcad630-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLosses_0dc618ca-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAggregateLosses_0dcad630-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_0e08560e-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="agnc-20140331.xsd#agnc_AvailableForSaleSecuritiesPar" xlink:label="loc_agnc_AvailableForSaleSecuritiesPar_4965dd16-6049-f6ef-76b5-cb38edef13f6" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_0e08560e-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_AvailableForSaleSecuritiesPar_4965dd16-6049-f6ef-76b5-cb38edef13f6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_26a75dfe-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_0e08560e-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_26a75dfe-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium_26da554c-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_0e08560e-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedPremium_26da554c-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_TotalAgencySecurities" xlink:label="loc_agnc_TotalAgencySecurities_8121d8cb-747d-815f-0695-cb38ec59bd7c" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0dd57554-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_TotalAgencySecurities_8121d8cb-747d-815f-0695-cb38ec59bd7c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0dd57554-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestRateDerivativeAssetsAtFairValue" xlink:label="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_68174358-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_TotalAgencySecurities_8121d8cb-747d-815f-0695-cb38ec59bd7c" xlink:to="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_68174358-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_InterestRateDerivativeAssetsAtAmortizedCost" xlink:label="loc_agnc_InterestRateDerivativeAssetsAtAmortizedCost_5999e45b-9211-5ec0-dbed-cb38edd83a4f" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_68174358-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_InterestRateDerivativeAssetsAtAmortizedCost_5999e45b-9211-5ec0-dbed-cb38edd83a4f" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_UnrealizedGainOnDerivatives" xlink:label="loc_agnc_UnrealizedGainOnDerivatives_abe005e1-958b-cce2-fcb7-cb38f2311d0d" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_68174358-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_UnrealizedGainOnDerivatives_abe005e1-958b-cce2-fcb7-cb38f2311d0d" xlink:type="arc" />
    <loc xlink:href="agnc-20140331.xsd#agnc_UnrealizedLossOnDerivatives" xlink:label="loc_agnc_UnrealizedLossOnDerivatives_343ee96b-6257-2fb4-61e1-cb38e979db6b" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_68174358-9656-11e2-88e7-12313d1a0274" xlink:to="loc_agnc_UnrealizedLossOnDerivatives_343ee96b-6257-2fb4-61e1-cb38e979db6b" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/ManagementAgreementAndRelatedPartyTransactionsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/ManagementAgreementAndRelatedPartyTransactionsNotes" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/ManagementAgreementAndRelatedPartyTransactionsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/Organization" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/OrganizationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsNotes" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsPledgedAssetsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebt" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseAgreementsPolicies" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquity" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_062fd1c8-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_062d1690-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_062fd1c8-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_062d1690-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_2a17983c-9656-11e2-88e7-12313d1a0274" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_062fd1c8-9656-11e2-88e7-12313d1a0274" xlink:to="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_2a17983c-9656-11e2-88e7-12313d1a0274" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityEquityOfferingsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquitySummaryOfFollowOnPublicOfferingsOfCommonStockDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/SubsequentEventNotes" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/SubsequentEventTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="extended" />
  <calculationLink xlink:role="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:type="extended" />
</linkbase>
