<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:href="agnc-20200331.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:href="agnc-20200331.xsd#ConsolidatedBalanceSheetsParentheticals" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:href="agnc-20200331.xsd#ConsolidatedStatementOfStockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="agnc-20200331.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:href="agnc-20200331.xsd#ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstruments" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:href="agnc-20200331.xsd#DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:href="agnc-20200331.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurements" xlink:href="agnc-20200331.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:href="agnc-20200331.xsd#FairValueMeasurementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:href="agnc-20200331.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecurities" xlink:href="agnc-20200331.xsd#InvestmentSecurities" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:href="agnc-20200331.xsd#InvestmentSecuritiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:href="agnc-20200331.xsd#NetIncomeLossPerCommonShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:href="agnc-20200331.xsd#NetIncomeLossPerCommonShareNotes" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:href="agnc-20200331.xsd#NetIncomeLossPerCommonShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/Organization" xlink:href="agnc-20200331.xsd#Organization" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/OrganizationDetails" xlink:href="agnc-20200331.xsd#OrganizationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssets" xlink:href="agnc-20200331.xsd#PledgedAssets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:href="agnc-20200331.xsd#PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:href="agnc-20200331.xsd#PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:href="agnc-20200331.xsd#PledgedAssetsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:href="agnc-20200331.xsd#PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:href="agnc-20200331.xsd#PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:href="agnc-20200331.xsd#PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsTables" xlink:href="agnc-20200331.xsd#PledgedAssetsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:href="agnc-20200331.xsd#RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:href="agnc-20200331.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:href="agnc-20200331.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:href="agnc-20200331.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:href="agnc-20200331.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquity" xlink:href="agnc-20200331.xsd#StockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityLongTermIncentivePlanDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityLongTermIncentivePlanDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityPreferredStockDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:href="agnc-20200331.xsd#StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityTables" xlink:href="agnc-20200331.xsd#StockholdersEquityTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEvent" xlink:href="agnc-20200331.xsd#SubsequentEvent" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEventDetails" xlink:href="agnc-20200331.xsd#SubsequentEventDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="agnc-20200331.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:href="agnc-20200331.xsd#SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="agnc-20200331.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:href="agnc-20200331.xsd#SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:href="agnc-20200331.xsd#SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:href="agnc-20200331.xsd#SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:href="agnc-20200331.xsd#UnauditedInterimConsolidatedFinancialStatements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_74442CC1593B31C96D81FF3F59D693FB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_74442CC1593B31C96D81FF3F59D693FB" xlink:to="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_4DB44716FCFE3069835EFF3F59D7A71C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_4DB44716FCFE3069835EFF3F59D7A71C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue" xlink:label="loc_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_E860D202BB5491FFE47DFF79A9252EA1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_agnc_Agencysecuritiestransferredtoconsolidatedvariableinterestentitiesatfairvalue_E860D202BB5491FFE47DFF79A9252EA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_1EB195204B5E426DF521FF766D5D8BD3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_AssetsCurrent_1EB195204B5E426DF521FF766D5D8BD3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_D89BA63046C060754871FF3F59D82D70" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_D89BA63046C060754871FF3F59D82D70" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NonAgencySecuritiesatFairValue" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_4831A2AA5F3DFA76B623FF3F59D86A22" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_4831A2AA5F3DFA76B623FF3F59D86A22" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_52B60B6B3F9F5ECEE8E8FF3F59D8D354" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_52B60B6B3F9F5ECEE8E8FF3F59D8D354" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_8A5D6A8065E532D02E25FF3F59D8DEBB" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_8A5D6A8065E532D02E25FF3F59D8DEBB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_A180A84BEA07919F6046FF3F59D9B56C" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_A180A84BEA07919F6046FF3F59D9B56C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_59B863073960771F6EADFF3F59D9F102" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_DerivativeAssets_59B863073960771F6EADFF3F59D9F102" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations" xlink:label="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_849ED75B877FA6A2B0E1FF3F59D9EF36" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_849ED75B877FA6A2B0E1FF3F59D9EF36" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_A00FD77B6AEA513DC044FF3F59D9A893" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_A00FD77B6AEA513DC044FF3F59D9A893" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_5390FF980B36BF3B5201FF3F59DA550B" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_5390FF980B36BF3B5201FF3F59DA550B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssets" xlink:label="loc_us-gaap_OtherAssets_9CA52EBED0D702750B27FF3F59DAD80A" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_OtherAssets_9CA52EBED0D702750B27FF3F59DAD80A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_5C4C985B1EA0CC59DBACFF3F59DAB14A" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_12F489DF67A656A759AEFF3F59D73EB2" xlink:to="loc_us-gaap_Assets_5C4C985B1EA0CC59DBACFF3F59DAB14A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAbstract" xlink:label="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_74442CC1593B31C96D81FF3F59D693FB" xlink:to="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_E74FCEC078AC2099148AFF3F59DAB32D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_E74FCEC078AC2099148AFF3F59DAB32D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_96BB8BC35E1B7051BDBFFF3F59DAF2DC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_us-gaap_OtherLongTermDebt_96BB8BC35E1B7051BDBFFF3F59DAF2DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:label="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_F61F7770A81F1E004B51FF3F59DBD3D6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_F61F7770A81F1E004B51FF3F59DBD3D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_BCCBEE491C4E2DD1D317FF3F59DB62E8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_us-gaap_DerivativeLiabilities_BCCBEE491C4E2DD1D317FF3F59DB62E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_6348E2FA66A944C4456AFF3F59DB94EB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_6348E2FA66A944C4456AFF3F59DB94EB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_7FBD72692540B36744AEFF3F59DBAA15" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_7FBD72692540B36744AEFF3F59DBAA15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_56FB9898151F8A8BEB00FF3F59DC62FE" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_56FB9898151F8A8BEB00FF3F59DC62FE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_E7AD9C56A5F76253ECC8FF3F59DCD52F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_38DAB640D64A44BFA8ABFF3F59DA1EE1" xlink:to="loc_us-gaap_Liabilities_E7AD9C56A5F76253ECC8FF3F59DCD52F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_74442CC1593B31C96D81FF3F59D693FB" xlink:to="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_EF0C80F15F62BCFEDA5DFF3F59DCD018" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:to="loc_us-gaap_PreferredStockValue_EF0C80F15F62BCFEDA5DFF3F59DCD018" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_237521E628ED10367CB0FF3F59DD4F89" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:to="loc_us-gaap_CommonStockValue_237521E628ED10367CB0FF3F59DD4F89" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_06259366F083FFA22D23FF3F59DDB176" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:to="loc_us-gaap_AdditionalPaidInCapital_06259366F083FFA22D23FF3F59DDB176" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_6533E2EDC031065A00BFFF3F59DD3151" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_6533E2EDC031065A00BFFF3F59DD3151" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_32CD3FEA86A0C256FCDBFF3F59DD645A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_32CD3FEA86A0C256FCDBFF3F59DD645A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_95030368C739ED9261A8FF3F59DDE1B0" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_86F6BE75310AF96596EAFF3F59DCA2BE" xlink:to="loc_us-gaap_StockholdersEquity_95030368C739ED9261A8FF3F59DDE1B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_F380BF03CA2151684034FF3F59DED895" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_74442CC1593B31C96D81FF3F59D693FB" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_F380BF03CA2151684034FF3F59DED895" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ConsolidatedBalanceSheetsParentheticalAbstract" xlink:label="loc_agnc_ConsolidatedBalanceSheetsParentheticalAbstract_455466FC1FEDEE0DD9DFFA4A84EFF501" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_D3DEA970130E59E6E4CDFA4A84EFBFB7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ConsolidatedBalanceSheetsParentheticalAbstract_455466FC1FEDEE0DD9DFFA4A84EFF501" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_D3DEA970130E59E6E4CDFA4A84EFBFB7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_4840516D8FBEE58FC58BFA4A84EF3849" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_D3DEA970130E59E6E4CDFA4A84EFBFB7" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_4840516D8FBEE58FC58BFA4A84EF3849" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_C89375A527F57DAE5D36FA4A84F09752" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_4840516D8FBEE58FC58BFA4A84EF3849" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_C89375A527F57DAE5D36FA4A84F09752" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetPledgedAsCollateralMember" xlink:label="loc_us-gaap_AssetPledgedAsCollateralMember_7202F8B3492F7FB276AAFA4A84F0B62B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_C89375A527F57DAE5D36FA4A84F09752" xlink:to="loc_us-gaap_AssetPledgedAsCollateralMember_7202F8B3492F7FB276AAFA4A84F0B62B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassAxis" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_B3690CD210C63AA6D304FA5519EC259F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_D3DEA970130E59E6E4CDFA4A84EFBFB7" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_B3690CD210C63AA6D304FA5519EC259F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassDomain" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_D6DAE8522342C28D5CC5FA557815ED93" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_B3690CD210C63AA6D304FA5519EC259F" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_D6DAE8522342C28D5CC5FA557815ED93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_9D2A27E7D4DA335D7DF6FA4A84F1866A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_D6DAE8522342C28D5CC5FA557815ED93" xlink:to="loc_us-gaap_AgencySecuritiesMember_9D2A27E7D4DA335D7DF6FA4A84F1866A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_4F34945580CD6A775FC2FA4A84F1F8EE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_D6DAE8522342C28D5CC5FA557815ED93" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_4F34945580CD6A775FC2FA4A84F1F8EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_2CDC7560E63720D44D34FA4A84F1C948" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_D6DAE8522342C28D5CC5FA557815ED93" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_2CDC7560E63720D44D34FA4A84F1C948" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_3BAC49E21BDDB6CD949EFA4A84F19327" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_D6DAE8522342C28D5CC5FA557815ED93" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_3BAC49E21BDDB6CD949EFA4A84F19327" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReceivableforsecuritiessoldMember" xlink:label="loc_agnc_ReceivableforsecuritiessoldMember_08B0CAB5583777179C42FA4A84F2355C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_D6DAE8522342C28D5CC5FA557815ED93" xlink:to="loc_agnc_ReceivableforsecuritiessoldMember_08B0CAB5583777179C42FA4A84F2355C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralTable_D3DEA970130E59E6E4CDFA4A84EFBFB7" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_A0119403AD9A34E8A636FA4A84F2957D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_A0119403AD9A34E8A636FA4A84F2957D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFairValue" xlink:label="loc_us-gaap_DebtInstrumentFairValue_8E462C7A3C6CE6082ABEFA4A84F2E133" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_DebtInstrumentFairValue_8E462C7A3C6CE6082ABEFA4A84F2E133" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_5E2B0FC2514336C65D45FA4A84F2FF22" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_5E2B0FC2514336C65D45FA4A84F2FF22" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockBLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue_89797681DBD19C8D4224FA4A84F33904" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_agnc_PreferredStockBLiquidationPreferenceValue_89797681DBD19C8D4224FA4A84F33904" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_A2B23E0515423F3330E4FA4A84F300BE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_A2B23E0515423F3330E4FA4A84F300BE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockCLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue_AE7179C77E92036F33A2FA4A84F3B239" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_agnc_PreferredStockCLiquidationPreferenceValue_AE7179C77E92036F33A2FA4A84F3B239" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockDLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockDLiquidationPreferenceValue_3842885CE4A15A9ED8B1FA4A84F36B32" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_agnc_PreferredStockDLiquidationPreferenceValue_3842885CE4A15A9ED8B1FA4A84F36B32" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_81E6A4FF6D81044F72A9FA4A84F3308F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_81E6A4FF6D81044F72A9FA4A84F3308F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_A8A4A96CA22BC85BEE8FFA4A84F33942" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_A8A4A96CA22BC85BEE8FFA4A84F33942" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_07651F474EC0E6CED50DFA4A84F4B631" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_CommonStockSharesIssued_07651F474EC0E6CED50DFA4A84F4B631" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7AA21EE43B17E5A3458FFA4A84F45609" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentsOwnedAndPledgedAsCollateralLineItems_EAAED9312CD7F4157B47FA4A84F2C4AC" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7AA21EE43B17E5A3458FFA4A84F45609" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_29AE91EEBE94AE83EF96E553CCD7A143" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_7E3A4C472AD2162597DAE553CCD7540E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_29AE91EEBE94AE83EF96E553CCD7A143" xlink:to="loc_us-gaap_StatementTable_7E3A4C472AD2162597DAE553CCD7540E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5DD1CD8766760F74F25CE553CCD7C2B8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7E3A4C472AD2162597DAE553CCD7540E" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5DD1CD8766760F74F25CE553CCD7C2B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_049EC4339FF2E34E2A92E553CCDC0B96" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5DD1CD8766760F74F25CE553CCD7C2B8" xlink:to="loc_us-gaap_ClassOfStockDomain_049EC4339FF2E34E2A92E553CCDC0B96" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_05DB2483DB2AB2B099CCE553CCDDF542" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_049EC4339FF2E34E2A92E553CCDC0B96" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_05DB2483DB2AB2B099CCE553CCDDF542" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_C402C42B4CEF472756DAE553CCDD3640" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_049EC4339FF2E34E2A92E553CCDC0B96" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_C402C42B4CEF472756DAE553CCDD3640" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_3AFF8605E775B873A34CE553CCDD1727" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_049EC4339FF2E34E2A92E553CCDC0B96" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_3AFF8605E775B873A34CE553CCDD1727" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_FB3BEED9362F90679517E553CCDE51CD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_049EC4339FF2E34E2A92E553CCDC0B96" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_FB3BEED9362F90679517E553CCDE51CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_9833AD4154AC1B59ED79E553CCDED3EE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7E3A4C472AD2162597DAE553CCD7540E" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_9833AD4154AC1B59ED79E553CCDED3EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_1265C516068B23575F60E553CCDEC455" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_9833AD4154AC1B59ED79E553CCDED3EE" xlink:to="loc_us-gaap_EquityComponentDomain_1265C516068B23575F60E553CCDEC455" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_40D1FB6ADB427CA74BABE553CCDECF00" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1265C516068B23575F60E553CCDEC455" xlink:to="loc_us-gaap_PreferredStockMember_40D1FB6ADB427CA74BABE553CCDECF00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_40352F784FDC6EB2CC8FE553CCDF5226" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1265C516068B23575F60E553CCDEC455" xlink:to="loc_us-gaap_CommonStockMember_40352F784FDC6EB2CC8FE553CCDF5226" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_B07A67DCE2ED5F48D7E9E553CCDF1508" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1265C516068B23575F60E553CCDEC455" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_B07A67DCE2ED5F48D7E9E553CCDF1508" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_10D37179A3A67CCB3A27E553CCDF83B7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1265C516068B23575F60E553CCDEC455" xlink:to="loc_us-gaap_RetainedEarningsMember_10D37179A3A67CCB3A27E553CCDF83B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2E42757BCEF9297BB9BAE553CCDFBDA0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1265C516068B23575F60E553CCDEC455" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2E42757BCEF9297BB9BAE553CCDFBDA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7E3A4C472AD2162597DAE553CCD7540E" xlink:to="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_DD4DA211BF85418AF036E553CCE0E073" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockholdersEquity_DD4DA211BF85418AF036E553CCE0E073" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_50A74EE779006772D76FE553CCE04CF3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_50A74EE779006772D76FE553CCE04CF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_078EF2873A10F7F61B7CE553CCE06F21" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_NetIncomeLoss_078EF2873A10F7F61B7CE553CCE06F21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1EA696CE9444351D27F8E553CCE059F6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1EA696CE9444351D27F8E553CCE059F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_59411BCAF5C6A8256169E553CCE1DB36" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1EA696CE9444351D27F8E553CCE059F6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_59411BCAF5C6A8256169E553CCE1DB36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_0FB3A3F62064AC794D42E553CCE1A18A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1EA696CE9444351D27F8E553CCE059F6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_0FB3A3F62064AC794D42E553CCE1A18A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_0713AF84DB2010C2A312E553CCE148EC" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_0713AF84DB2010C2A312E553CCE148EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_E8D962645A0472F200C5E553CCE14082" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_E8D962645A0472F200C5E553CCE14082" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_E196E56706A2C9BA7B0DE553CCE23930" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_E196E56706A2C9BA7B0DE553CCE23930" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_80BD7C27877727907FE2E553CCE25C4F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_80BD7C27877727907FE2E553CCE25C4F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_C1211D4D32525EB9CB97E553CCE277A6" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_C1211D4D32525EB9CB97E553CCE277A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_010758C93E2BF8AD9A5DE553CCE2AAD3" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_010758C93E2BF8AD9A5DE553CCE2AAD3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Issuancecostsofredeemedpreferredstock" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_3B951E26606BC89C7512E553CCE29968" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_3B951E26606BC89C7512E553CCE29968" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_0EA52E59D98CCF47C830E553CCE2F5EE" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_0EA52E59D98CCF47C830E553CCE2F5EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_4477F551ED909A892EB9E553CCE34884" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_4477F551ED909A892EB9E553CCE34884" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_F3B3D2255B0EA6F3D3F9E553CCE31476" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_F3B3D2255B0EA6F3D3F9E553CCE31476" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_9FCF0FEDCD6B8F6C0155E553CCE362B8" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_9FCF0FEDCD6B8F6C0155E553CCE362B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="loc_us-gaap_DividendsPreferredStockCash_BBDE0D8519F95B2E63D3E553CCE311DC" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_DividendsPreferredStockCash_BBDE0D8519F95B2E63D3E553CCE311DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCommonStockCash" xlink:label="loc_us-gaap_DividendsCommonStockCash_E62255448CE30E8BD67AE553CCE3463C" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_DividendsCommonStockCash_E62255448CE30E8BD67AE553CCE3463C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_B7A6F09EFB43375321EBE553CCE44198" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_StockholdersEquity_B7A6F09EFB43375321EBE553CCE44198" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_DA919103C5B33FCBE92FE553CCE9D083" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EA6542A790E4AD90B90BE553CCDFDCF1" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_DA919103C5B33FCBE92FE553CCE9D083" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_2D010000751323201402FB3072D6B0D9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_2D010000751323201402FB3072D6B0D9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_5EBD64B0245A4DBE8C18FB3072D656F9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_InterestPaid_5EBD64B0245A4DBE8C18FB3072D656F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_AFFF5A3CFB2F4FDEADE3FB3072D72161" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_AFFF5A3CFB2F4FDEADE3FB3072D72161" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_DBC151854A04556AD2B3FB3072D7CF9F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_AFFF5A3CFB2F4FDEADE3FB3072D72161" xlink:to="loc_us-gaap_NetIncomeLoss_DBC151854A04556AD2B3FB3072D7CF9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_AFFF5A3CFB2F4FDEADE3FB3072D72161" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_0A3B71924E09A7A7B966FB3072D801EC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_0A3B71924E09A7A7B966FB3072D801EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_FDC649720394EE198EACFB3072D85A74" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_FDC649720394EE198EACFB3072D85A74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_81C36E34851A197233B0FB3072D98A1D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_us-gaap_ShareBasedCompensation_81C36E34851A197233B0FB3072D98A1D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_D995BDF4B4BC687CA317FB3072D9F0A3" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_D995BDF4B4BC687CA317FB3072D9F0A3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome" xlink:label="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_8D1D934A98B6E39C31F2FB3072D96E1B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_8D1D934A98B6E39C31F2FB3072D96E1B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_E69FBB1A7F82B15181C6FB3072DA1C28" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_E69FBB1A7F82B15181C6FB3072DA1C28" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_14C9BD04FCCC3AF7B5F4FB3072DAE185" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_14C9BD04FCCC3AF7B5F4FB3072DAE185" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_596D4BD8F4C39073DEE4FB3072DA8EDB" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_596D4BD8F4C39073DEE4FB3072DA8EDB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_FA2115A6DBEC3A296428FB3072DB8671" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_892A689E99BEA095120FFB3072D8FA9F" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_FA2115A6DBEC3A296428FB3072DB8671" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_EA984CDBC100F96CEEE8FB3072DB8658" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_EA984CDBC100F96CEEE8FB3072DB8658" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:label="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_758A92BE4DFA7A281FC6FB3072DBFE5A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_758A92BE4DFA7A281FC6FB3072DBFE5A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_E481F1D7427FFB42EC2CFB3072DCFD79" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_E481F1D7427FFB42EC2CFB3072DCFD79" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities" xlink:label="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_CA3B806D86FEF1288A03FB3072DD1628" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_CA3B806D86FEF1288A03FB3072DD1628" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_13C44C0694EFB71DEB3FFB3072DDC5F0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_13C44C0694EFB71DEB3FFB3072DDC5F0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:label="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_7165E2FE95E499666482FB3072DEA2F0" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_7165E2FE95E499666482FB3072DEA2F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_76DD35F9F11D9ADE9840FB3072DE30E0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_76DD35F9F11D9ADE9840FB3072DE30E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_B82B85D40BFD989165BFFB3072DE8DEC" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_B82B85D40BFD989165BFFB3072DE8DEC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:label="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_851CEBB005CE1A5CC631FB3072DE725D" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_851CEBB005CE1A5CC631FB3072DE725D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_F4220AA677A8DAA636D6FB36134D9009" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_F4220AA677A8DAA636D6FB36134D9009" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_F90FC44CBB0FEEBAD845FB3072DF9666" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_492B2A3E033B28A03F22FB3072DB9388" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_F90FC44CBB0FEEBAD845FB3072DF9666" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_2A6BBD3B7C31F159A9D8FB3072E07E19" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_2A6BBD3B7C31F159A9D8FB3072E07E19" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_AD854D785098B06ABD13FB3072E00F31" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_AD854D785098B06ABD13FB3072E00F31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfOtherDebt" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_B2BD20BBE08325889930FB3072E17B77" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_B2BD20BBE08325889930FB3072E17B77" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings" xlink:label="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_028907317CBE0801CBDDFB3072E1E86C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_028907317CBE0801CBDDFB3072E1E86C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_0A896AA011C158ABD1CBFB3072E13DA8" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_0A896AA011C158ABD1CBFB3072E13DA8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_666C7D1DD3F9A0D22D3AFB3072E1B803" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_666C7D1DD3F9A0D22D3AFB3072E1B803" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_560B286CCC7FBC5E0B62FB3072E2B74A" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_560B286CCC7FBC5E0B62FB3072E2B74A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3E7FAC095272C302EF9AFB3072E22F6B" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3E7FAC095272C302EF9AFB3072E22F6B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_32EA5EC47E1A7259E79FFB3072E2E802" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_PaymentsOfDividends_32EA5EC47E1A7259E79FFB3072E2E802" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_E92D2844C5074FD8AC99FB3072E3FBD0" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE6471B7649056B1D4B6FB3072E034F3" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_E92D2844C5074FD8AC99FB3072E3FBD0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3F57CE7963888EA72B37FB3072E31015" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3F57CE7963888EA72B37FB3072E31015" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_794B856E93CDA0B124EAFB3072E3DA32" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_794B856E93CDA0B124EAFB3072E3DA32" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_3546652E02A0E96E505CFB3072E3E5B0" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_0C4702E8C6E76DA4511AFB3072D5492F" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_3546652E02A0E96E505CFB3072E3E5B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_4AC9EED96600B8B02B19FB3072E4E1F5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_3546652E02A0E96E505CFB3072E3E5B0" xlink:to="loc_us-gaap_IncomeTaxesPaid_4AC9EED96600B8B02B19FB3072E4E1F5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_412D7802C2CF541CEDB7F70756F04DAC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_StatementTable_412D7802C2CF541CEDB7F70756F04DAC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementScenarioAxis" xlink:label="loc_srt_StatementScenarioAxis_B5A4A90EF635AFFC4EC4F70756F0C274" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_412D7802C2CF541CEDB7F70756F04DAC" xlink:to="loc_srt_StatementScenarioAxis_B5A4A90EF635AFFC4EC4F70756F0C274" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="loc_srt_ScenarioUnspecifiedDomain_D7C25AD0AC36A24E9115F70756F17F64" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementScenarioAxis_B5A4A90EF635AFFC4EC4F70756F0C274" xlink:to="loc_srt_ScenarioUnspecifiedDomain_D7C25AD0AC36A24E9115F70756F17F64" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_4F6242FC0A2E459DB005F70756F1CBCD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_412D7802C2CF541CEDB7F70756F04DAC" xlink:to="loc_us-gaap_StatementLineItems_4F6242FC0A2E459DB005F70756F1CBCD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Issuancecostsofredeemedpreferredstock" xlink:label="loc_agnc_Issuancecostsofredeemedpreferredstock_B8FD9A4728BC73161871F70756F1E133" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4F6242FC0A2E459DB005F70756F1CBCD" xlink:to="loc_agnc_Issuancecostsofredeemedpreferredstock_B8FD9A4728BC73161871F70756F1E133" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_350DD98DEB950C9812A4F70756F2D14B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4F6242FC0A2E459DB005F70756F1CBCD" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_350DD98DEB950C9812A4F70756F2D14B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeExpenseNetAbstract" xlink:label="loc_us-gaap_InterestIncomeExpenseNetAbstract_6870B100D6C57B06C44EF70756F2C10D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_InterestIncomeExpenseNetAbstract_6870B100D6C57B06C44EF70756F2C10D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_EE03039FDC9C4D3075D1F70756F2AFA7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_6870B100D6C57B06C44EF70756F2C10D" xlink:to="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_EE03039FDC9C4D3075D1F70756F2AFA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_7E6EC120840DF8EEF15EF70756F28BA1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_6870B100D6C57B06C44EF70756F2C10D" xlink:to="loc_us-gaap_InterestExpense_7E6EC120840DF8EEF15EF70756F28BA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeExpenseNet" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_9AFF08FBCF48E316B6F1F70756F20D88" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeExpenseNetAbstract_6870B100D6C57B06C44EF70756F2C10D" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_9AFF08FBCF48E316B6F1F70756F20D88" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoninterestIncomeAbstract" xlink:label="loc_us-gaap_NoninterestIncomeAbstract_BB502EDF1BF4915F30ADF70756F3AD99" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_NoninterestIncomeAbstract_BB502EDF1BF4915F30ADF70756F3AD99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_64234BD4FECC69BCCA69F70756F3D20A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_BB502EDF1BF4915F30ADF70756F3AD99" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_64234BD4FECC69BCCA69F70756F3D20A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_324B646F905B1B51CCF0F70756F3751B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_BB502EDF1BF4915F30ADF70756F3AD99" xlink:to="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_324B646F905B1B51CCF0F70756F3751B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_440A83E779907C1E5118F70756F4A8AD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_BB502EDF1BF4915F30ADF70756F3AD99" xlink:to="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_440A83E779907C1E5118F70756F4A8AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoninterestIncome" xlink:label="loc_us-gaap_NoninterestIncome_982FE92BF92A74ACBBB2F70756F40415" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_BB502EDF1BF4915F30ADF70756F3AD99" xlink:to="loc_us-gaap_NoninterestIncome_982FE92BF92A74ACBBB2F70756F40415" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoninterestExpenseAbstract" xlink:label="loc_us-gaap_NoninterestExpenseAbstract_3DA9B201D265220E60CDF70756F4F107" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_NoninterestExpenseAbstract_3DA9B201D265220E60CDF70756F4F107" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LaborAndRelatedExpense" xlink:label="loc_us-gaap_LaborAndRelatedExpense_9D4D5117C48C1D82EA72F70756F4F796" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_3DA9B201D265220E60CDF70756F4F107" xlink:to="loc_us-gaap_LaborAndRelatedExpense_9D4D5117C48C1D82EA72F70756F4F796" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_798D31C8F035E50FF6B9F70756F51964" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_3DA9B201D265220E60CDF70756F4F107" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_798D31C8F035E50FF6B9F70756F51964" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_0B2C8C858166532EBADCF70756F5D31B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_3DA9B201D265220E60CDF70756F4F107" xlink:to="loc_us-gaap_OperatingExpenses_0B2C8C858166532EBADCF70756F5D31B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_36A0285E435DC8A6BF2CF70756F5CC44" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_NetIncomeLoss_36A0285E435DC8A6BF2CF70756F5CC44" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_7827682AB9211B9E0EE4F70756F58358" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_7827682AB9211B9E0EE4F70756F58358" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_BE2C1A21EE2EB5DA2357F70756F5C85B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_BE2C1A21EE2EB5DA2357F70756F5C85B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1E63E601E95FD88742C5F70756F5E86A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1E63E601E95FD88742C5F70756F5E86A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_A147FBF9103A0BFD1D62F70756F6EE2D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_1E63E601E95FD88742C5F70756F5E86A" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_A147FBF9103A0BFD1D62F70756F6EE2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_040B192C25374B1CA85EF70756F62FDD" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_040B192C25374B1CA85EF70756F62FDD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F475B891DC0D63FA3F40F70756F67A5F" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_F475B891DC0D63FA3F40F70756F67A5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_66DD76300DEFE5C3D854F70756F61A2F" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_66DD76300DEFE5C3D854F70756F61A2F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_430DCA604BE40E4D04B4F70756F76EBA" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_430DCA604BE40E4D04B4F70756F76EBA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_B5EB2C04C5C662868AB5F70756F7FA03" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_EarningsPerShareBasic_B5EB2C04C5C662868AB5F70756F7FA03" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_4CB88C1A56461A9A377CF70756F76557" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B51C75385AD9DC539165F70756F07AAD" xlink:to="loc_us-gaap_EarningsPerShareDiluted_4CB88C1A56461A9A377CF70756F76557" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_CE2B2BC4149454C9AB43A9213C4F418A" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_USGovernmentFuturesSecuritiesTableTextBlock" xlink:label="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_93250D6BC7D758C28B4FB6D0B96C9452" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_CE2B2BC4149454C9AB43A9213C4F418A" xlink:to="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_93250D6BC7D758C28B4FB6D0B96C9452" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_787F29FB17875A91B707B0524FA654DB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_CE2B2BC4149454C9AB43A9213C4F418A" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_787F29FB17875A91B707B0524FA654DB" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_65BED6D1AC89C6197087019554EE9D73" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_65BED6D1AC89C6197087019554EE9D73" xlink:to="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_63AB3CF0678E15C23C4F019554EEFFA2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_FinancialInstrumentAxis_63AB3CF0678E15C23C4F019554EEFFA2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_60BBCB9F5EC289927AA2019554EF4F47" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_63AB3CF0678E15C23C4F019554EEFFA2" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_60BBCB9F5EC289927AA2019554EF4F47" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_0B882393AE8286F8D7D6019554EF49AC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_60BBCB9F5EC289927AA2019554EF4F47" xlink:to="loc_us-gaap_FutureMember_0B882393AE8286F8D7D6019554EF49AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_52757315A54710955660019554EF255A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_PositionAxis_52757315A54710955660019554EF255A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_C2B52A42F0F913298DC8019554EFD3D5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_52757315A54710955660019554EF255A" xlink:to="loc_us-gaap_PositionDomain_C2B52A42F0F913298DC8019554EFD3D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_BDE4A35386F54F2282A9019554F0BB4D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_C2B52A42F0F913298DC8019554EFD3D5" xlink:to="loc_us-gaap_ShortMember_BDE4A35386F54F2282A9019554F0BB4D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_C3C91F2CDE108039C7AB019554F0B41C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_C2B52A42F0F913298DC8019554EFD3D5" xlink:to="loc_us-gaap_LongMember_C3C91F2CDE108039C7AB019554F0B41C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_8CA1E6E9E545441A82C9019554F0638A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_HedgingDesignationAxis_8CA1E6E9E545441A82C9019554F0638A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_14C2EA0447A6BD037673019554F07BA1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_8CA1E6E9E545441A82C9019554F0638A" xlink:to="loc_us-gaap_HedgingDesignationDomain_14C2EA0447A6BD037673019554F07BA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_7D0BBEBA80FF4BDDD348019554F0E459" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_14C2EA0447A6BD037673019554F07BA1" xlink:to="loc_us-gaap_NondesignatedMember_7D0BBEBA80FF4BDDD348019554F0E459" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_D3873C21BBA7F72793E4019554F1283B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_InvestmentTypeAxis_D3873C21BBA7F72793E4019554F1283B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_31C517DA10471DEB50CF019554F1E307" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_D3873C21BBA7F72793E4019554F1283B" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_31C517DA10471DEB50CF019554F1E307" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_CBFB64520334949BF1C8019554F1EA69" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_31C517DA10471DEB50CF019554F1E307" xlink:to="loc_agnc_OtherDerivativesMember_CBFB64520334949BF1C8019554F1EA69" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_FA9E39276BC2AF37CA29019554F14CBB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_31C517DA10471DEB50CF019554F1E307" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_FA9E39276BC2AF37CA29019554F14CBB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_D58D97A153088D7EAA96019554F23D47" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_D58D97A153088D7EAA96019554F23D47" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_D58D97A153088D7EAA96019554F23D47" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestrateswapreceiverMember" xlink:label="loc_agnc_InterestrateswapreceiverMember_3157D33BD130B4F8A2AC019554F2D230" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_agnc_InterestrateswapreceiverMember_3157D33BD130B4F8A2AC019554F2D230" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PayerSwaptionMember" xlink:label="loc_agnc_PayerSwaptionMember_3BCD76EE6C18A7722B21019554F2F41E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_agnc_PayerSwaptionMember_3BCD76EE6C18A7722B21019554F2F41E" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_us-gaap_FutureMember_0B882393AE8286F8D7D6019554EF49AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_8E5967BF7678A3FA959A019554F3CC32" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_us-gaap_InterestRateSwaptionMember_8E5967BF7678A3FA959A019554F3CC32" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_E60A3740D69A33D9E6E9019554F3B40F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_E60A3740D69A33D9E6E9019554F3B40F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_C024F175204653ACBAC4019554F3BAAA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_C024F175204653ACBAC4019554F3BAAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_D32F93F7C2339E65A0A4019554F37281" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_us-gaap_InterestRateSwapMember_D32F93F7C2339E65A0A4019554F37281" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_497082037039BF52B4DA019554F3B48A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_497082037039BF52B4DA019554F3B48A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReceiverSwaptionMember" xlink:label="loc_agnc_ReceiverSwaptionMember_777C5873EA1673B5697F019554F31E66" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_95EB1CE57A5D2A2A55F5019554F2A273" xlink:to="loc_agnc_ReceiverSwaptionMember_777C5873EA1673B5697F019554F31E66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_FFB317FFE4D4484C72E1019554F42B5C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_FFB317FFE4D4484C72E1019554F42B5C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_133C4AA904A2CEDD4847019554F4D7DC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_FFB317FFE4D4484C72E1019554F42B5C" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_133C4AA904A2CEDD4847019554F4D7DC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3A4E56CFB07052DD3E64019554F41518" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_133C4AA904A2CEDD4847019554F4D7DC" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3A4E56CFB07052DD3E64019554F41518" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_133C4AA904A2CEDD4847019554F4D7DC" xlink:to="loc_us-gaap_InterestRateSwapMember_D32F93F7C2339E65A0A4019554F37281" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_133C4AA904A2CEDD4847019554F4D7DC" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_C024F175204653ACBAC4019554F3BAAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_B5276A103B3CAC3AC3F9019554F5D219" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_133C4AA904A2CEDD4847019554F4D7DC" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_B5276A103B3CAC3AC3F9019554F5D219" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_2EFE050A18C3E4930848019554F5B9F6" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_2EFE050A18C3E4930848019554F5B9F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_0A20525537C99E951313019554F5CE48" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_2EFE050A18C3E4930848019554F5B9F6" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_0A20525537C99E951313019554F5CE48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_0C91341C6F1755190326019554EED478" xlink:to="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" xlink:label="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_36CA413B4ADB2910DE8A019554F53A26" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:to="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_36CA413B4ADB2910DE8A019554F53A26" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="loc_us-gaap_DerivativeNotionalAmount_9F69AE208B199C4ED8E0019554F6A793" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_36CA413B4ADB2910DE8A019554F53A26" xlink:to="loc_us-gaap_DerivativeNotionalAmount_9F69AE208B199C4ED8E0019554F6A793" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_AA8ABF5AFD8FA930FD12019554F6E32B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_36CA413B4ADB2910DE8A019554F53A26" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_AA8ABF5AFD8FA930FD12019554F6E32B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_275FFF377426FB98875E019554F6714E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_36CA413B4ADB2910DE8A019554F53A26" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_275FFF377426FB98875E019554F6714E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_C4F7F15772A5B5EA8D80019554F6492A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward_36CA413B4ADB2910DE8A019554F53A26" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_C4F7F15772A5B5EA8D80019554F6492A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_2152E24CAC0CF56117C7019554F655FA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_2152E24CAC0CF56117C7019554F655FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecurities" xlink:label="loc_us-gaap_TradingSecurities_E7D21F2BB2D61A162CDA019554F71423" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:to="loc_us-gaap_TradingSecurities_E7D21F2BB2D61A162CDA019554F71423" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TradingSecuritiesAddedDuringthePeriod" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_27616BED5F338261F206019554F7EEEB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_27616BED5F338261F206019554F7EEEB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_0597C91980E7E681F4CA019554F7C97B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_0597C91980E7E681F4CA019554F7C97B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_A401AEB564270FEA7836019554F7F322" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_32878337EA176847B185019554F5A7EE" xlink:to="loc_agnc_GainLossOnOtherDebt_A401AEB564270FEA7836019554F7F322" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_EDEC5B1F77B351A89386004ABFC9E43B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_EDEC5B1F77B351A89386004ABFC9E43B" xlink:to="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_4E9D44FCA5985E02B6F2136B0DF05BD7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:to="loc_us-gaap_PositionAxis_4E9D44FCA5985E02B6F2136B0DF05BD7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_EB857294575A5FE5BF63E20300BC8CB0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_4E9D44FCA5985E02B6F2136B0DF05BD7" xlink:to="loc_us-gaap_PositionDomain_EB857294575A5FE5BF63E20300BC8CB0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_C96E12C15F365D70AA87A3772794CBEB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_EB857294575A5FE5BF63E20300BC8CB0" xlink:to="loc_us-gaap_ShortMember_C96E12C15F365D70AA87A3772794CBEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_21EAA028F9395FCFABAD525BC50397EA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_EB857294575A5FE5BF63E20300BC8CB0" xlink:to="loc_us-gaap_LongMember_21EAA028F9395FCFABAD525BC50397EA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_8A584A478F6B59DBACF9BF1E17E97474" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:to="loc_us-gaap_HedgingDesignationAxis_8A584A478F6B59DBACF9BF1E17E97474" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_0E07E4D4E910542C9945D45123EB6207" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_8A584A478F6B59DBACF9BF1E17E97474" xlink:to="loc_us-gaap_HedgingDesignationDomain_0E07E4D4E910542C9945D45123EB6207" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_E3A0A70484135448886C3EBBB895DEC8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_0E07E4D4E910542C9945D45123EB6207" xlink:to="loc_us-gaap_NondesignatedMember_E3A0A70484135448886C3EBBB895DEC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_6CDE8A20D0395337AF881324106ADCA4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_6CDE8A20D0395337AF881324106ADCA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_F412818BED1C54B3B3D4E6FB6C9F0DC6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_6CDE8A20D0395337AF881324106ADCA4" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_F412818BED1C54B3B3D4E6FB6C9F0DC6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_7FF9B0D943FE58DAA3A24AA4A509D6AD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_F412818BED1C54B3B3D4E6FB6C9F0DC6" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_7FF9B0D943FE58DAA3A24AA4A509D6AD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_5B9792EB3CD6580496BE54AD50CE5E10" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_F412818BED1C54B3B3D4E6FB6C9F0DC6" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_5B9792EB3CD6580496BE54AD50CE5E10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_27B875B411F35CC98AB29F09C3B8CCB3" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_27B875B411F35CC98AB29F09C3B8CCB3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_168C08AAA8CF5C52AF7FEB058DD46EB8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_27B875B411F35CC98AB29F09C3B8CCB3" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_168C08AAA8CF5C52AF7FEB058DD46EB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_B9124D0DF6235292B61006B72332E280" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_168C08AAA8CF5C52AF7FEB058DD46EB8" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_B9124D0DF6235292B61006B72332E280" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_BBB8A7847CD75378A46D70BF66D73A81" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_BBB8A7847CD75378A46D70BF66D73A81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_BBB8A7847CD75378A46D70BF66D73A81" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_5B9792EB3CD6580496BE54AD50CE5E10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_891B7877C896535781E45F8330DD4029" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:to="loc_us-gaap_InterestRateSwapMember_891B7877C896535781E45F8330DD4029" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_36071ED073095810ABC6865F952DDF0B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:to="loc_us-gaap_InterestRateSwaptionMember_36071ED073095810ABC6865F952DDF0B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_2207D9DCBD33517AB81E712892E7593D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_2207D9DCBD33517AB81E712892E7593D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_88511FCE979D5D29ADCA1DB39A89EB8A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:to="loc_us-gaap_FutureMember_88511FCE979D5D29ADCA1DB39A89EB8A" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_549CCDB39F115727953FEBAED2CBEAB7" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_7FF9B0D943FE58DAA3A24AA4A509D6AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_BFA1BF13ED64562B99AB4C25702B5109" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_BFA1BF13ED64562B99AB4C25702B5109" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_16FBBD3F0A3B57908E6DE95E73D8ACCF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_BFA1BF13ED64562B99AB4C25702B5109" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_16FBBD3F0A3B57908E6DE95E73D8ACCF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_BBEB3F88AC5850A3B3D867860620DCCB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_16FBBD3F0A3B57908E6DE95E73D8ACCF" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_BBEB3F88AC5850A3B3D867860620DCCB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_584D71511AEB5CD3934AE5398EE47E82" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_16FBBD3F0A3B57908E6DE95E73D8ACCF" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_584D71511AEB5CD3934AE5398EE47E82" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B818DB9C9B515BEEBEE2310A11F3F67E" xlink:to="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_5D4198FDDD5755F293E11A77F8109238" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_5D4198FDDD5755F293E11A77F8109238" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_D00AF1B274CD5C3FAABBAA4D133C11C2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_D00AF1B274CD5C3FAABBAA4D133C11C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_7EE6CCE9AD76538EBE85FBD4D4A39161" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue_7EE6CCE9AD76538EBE85FBD4D4A39161" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_95CCF8344E3B59BB8EA78A5D6945E62B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_DerivativeAssets_95CCF8344E3B59BB8EA78A5D6945E62B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_B5A70473842852AAA3C60CDC7D206964" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_DerivativeLiabilities_B5A70473842852AAA3C60CDC7D206964" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_8D704AD3F17958B0A0B961236CDD851B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_8D704AD3F17958B0A0B961236CDD851B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations" xlink:label="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_E66F6B0710B1546F9A1D2FFD95197FF1" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_FinancialInstrumentsSoldNotYetPurchasedUSGovernmentAndAgencyObligations_E66F6B0710B1546F9A1D2FFD95197FF1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Governmentbondsownedandsoldshortnet" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_12C13C43BCF259478B3698CD527C1696" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_agnc_Governmentbondsownedandsoldshortnet_12C13C43BCF259478B3698CD527C1696" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_B143E72D2F8255EDA7F7AFEC0AAF4F73" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_B143E72D2F8255EDA7F7AFEC0AAF4F73" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_9FB05D3F4C5552BD98525C7E6B2D6A65" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_9FB05D3F4C5552BD98525C7E6B2D6A65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_AFBB316A986A5CFF936FBDE2827FADD6" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_AFBB316A986A5CFF936FBDE2827FADD6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecurities" xlink:label="loc_us-gaap_TradingSecurities_FAC52BA160E15AD593A65C495C9E2607" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_us-gaap_TradingSecurities_FAC52BA160E15AD593A65C495C9E2607" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TradingSecuritiesAddedDuringthePeriod" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_F54C70E8364F57D190D27D8E4B83A166" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_F54C70E8364F57D190D27D8E4B83A166" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_C814F2CF30A156F3BC5E15CF88E5982A" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_7A733DE90EE15D57A6E82E86B773E9CE" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_C814F2CF30A156F3BC5E15CF88E5982A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_D30F27389ED455C8B5AA183653FF2297" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_D30F27389ED455C8B5AA183653FF2297" xlink:to="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_D4076722DBC058ABA8F822863D339CC3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_InvestmentTypeAxis_D4076722DBC058ABA8F822863D339CC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_085056C2894E5E9AB9E1FBE9F392C781" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_D4076722DBC058ABA8F822863D339CC3" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_085056C2894E5E9AB9E1FBE9F392C781" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_BB51CEBC13C05BE483E75116F200804C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_085056C2894E5E9AB9E1FBE9F392C781" xlink:to="loc_agnc_OtherDerivativesMember_BB51CEBC13C05BE483E75116F200804C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_1361903AD82C5C5B8CF8497D075151DF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_PositionAxis_1361903AD82C5C5B8CF8497D075151DF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_B96E4FDF0B7B567392FA779159716605" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_1361903AD82C5C5B8CF8497D075151DF" xlink:to="loc_us-gaap_PositionDomain_B96E4FDF0B7B567392FA779159716605" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_5C76C13E7E3F501AB0BE6D66251107F2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_B96E4FDF0B7B567392FA779159716605" xlink:to="loc_us-gaap_ShortMember_5C76C13E7E3F501AB0BE6D66251107F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_18F08A05F7235A8ABD34FF43F7D6734A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_B96E4FDF0B7B567392FA779159716605" xlink:to="loc_us-gaap_LongMember_18F08A05F7235A8ABD34FF43F7D6734A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_FB4D276BF10E513C903C72DDC8BCD9BD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_HedgingDesignationAxis_FB4D276BF10E513C903C72DDC8BCD9BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_33B253B75F325C8298F09727B2015C5A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_FB4D276BF10E513C903C72DDC8BCD9BD" xlink:to="loc_us-gaap_HedgingDesignationDomain_33B253B75F325C8298F09727B2015C5A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_F0C7339CC2645AED93819D3E4B97666F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_33B253B75F325C8298F09727B2015C5A" xlink:to="loc_us-gaap_NondesignatedMember_F0C7339CC2645AED93819D3E4B97666F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_A1744979A6075AACB90B3F61647DFFF0" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_A1744979A6075AACB90B3F61647DFFF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_CE8B114BB7CA59FAAE0CF9F433E43777" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_A1744979A6075AACB90B3F61647DFFF0" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_CE8B114BB7CA59FAAE0CF9F433E43777" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_7CDC98CD474157D18BCA113F78AC54B2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CE8B114BB7CA59FAAE0CF9F433E43777" xlink:to="loc_us-gaap_FutureMember_7CDC98CD474157D18BCA113F78AC54B2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_E3E0B45EBBA252409C15796E4C26F937" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CE8B114BB7CA59FAAE0CF9F433E43777" xlink:to="loc_us-gaap_ForwardContractsMember_E3E0B45EBBA252409C15796E4C26F937" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_5AF8B12D27A55AE7A647F7D0DF160D34" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CE8B114BB7CA59FAAE0CF9F433E43777" xlink:to="loc_us-gaap_InterestRateSwaptionMember_5AF8B12D27A55AE7A647F7D0DF160D34" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_92CAA642D77E5D3DB60DC1A82A41868A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CE8B114BB7CA59FAAE0CF9F433E43777" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_92CAA642D77E5D3DB60DC1A82A41868A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_BA0805341EA951989AD5A89C58524BF3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_CE8B114BB7CA59FAAE0CF9F433E43777" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_BA0805341EA951989AD5A89C58524BF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F81E957AFC5559639DA4A839DB70976B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_A1744979A6075AACB90B3F61647DFFF0" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F81E957AFC5559639DA4A839DB70976B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_5E6D887325C055F2B6478912B4080EBB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_agnc_DerivativePositionAxis_5E6D887325C055F2B6478912B4080EBB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_C62682775E3B59F7BA922D63C4DFF9AF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_5E6D887325C055F2B6478912B4080EBB" xlink:to="loc_agnc_DerivativePositionDomain_C62682775E3B59F7BA922D63C4DFF9AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_60443CA0D26458B0B8A96930B6323ADC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_C62682775E3B59F7BA922D63C4DFF9AF" xlink:to="loc_us-gaap_InterestRateSwapMember_60443CA0D26458B0B8A96930B6323ADC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_2A98C205DB0D512BB9922212CB6516B8" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_2A98C205DB0D512BB9922212CB6516B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_F93249F26AD35ED88A16055D05571970" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_2A98C205DB0D512BB9922212CB6516B8" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_F93249F26AD35ED88A16055D05571970" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_D97B7F685CDA5EFBA9FC09E29D0F42BC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_F93249F26AD35ED88A16055D05571970" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_D97B7F685CDA5EFBA9FC09E29D0F42BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_BF41019666E05BED8B5BC21F0BBEE361" xlink:type="locator" />
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_BF41019666E05BED8B5BC21F0BBEE361" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_F56DB8988C1455ACBB78B660E9825BB6" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_BF41019666E05BED8B5BC21F0BBEE361" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_F56DB8988C1455ACBB78B660E9825BB6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_9BBFBF4006215C478CC136E2718B5804" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_F56DB8988C1455ACBB78B660E9825BB6" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_9BBFBF4006215C478CC136E2718B5804" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_7139D7BA94B052E1A403007CB4FBC7CC" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_7139D7BA94B052E1A403007CB4FBC7CC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_1BE15643AE1B569B88160AD69F0C99B6" xlink:to="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_510ECEC425AC5FAAAB2EBD0A3D139B45" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_GainLossOnOtherDebt_510ECEC425AC5FAAAB2EBD0A3D139B45" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_AEA754A7A0785198B4210EA20A7BD633" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_AEA754A7A0785198B4210EA20A7BD633" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_626B750C2B6F5534876A380278C3D753" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_626B750C2B6F5534876A380278C3D753" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_369D7D2EBADB52BD861D02E7BC4703A3" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_369D7D2EBADB52BD861D02E7BC4703A3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_DB7F1A96EE0C5356A81159307224F5E9" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_DB7F1A96EE0C5356A81159307224F5E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_76E362AAA0695512ADB08E320D0A48D6" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_76E362AAA0695512ADB08E320D0A48D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_9DD074FB3AA6565EAB2518403E877A5C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_9DD074FB3AA6565EAB2518403E877A5C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_D9AC59CC633A5F9EB883A212A825E277" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod_D9AC59CC633A5F9EB883A212A825E277" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" xlink:label="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_A0D380D713EE57429A41E4EBB48646D3" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod_A0D380D713EE57429A41E4EBB48646D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_797A61668B03550B87EAC7A672E385AF" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_797A61668B03550B87EAC7A672E385AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_9E01EB549BE756F69DDB4ACED7AC5988" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_9E01EB549BE756F69DDB4ACED7AC5988" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_97F252EB569C5B68A98C2A4C3D0C54AB" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_OptionsAtCost_97F252EB569C5B68A98C2A4C3D0C54AB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_223346ECE4175173972DBD51D0453276" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_223346ECE4175173972DBD51D0453276" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TradingSecuritiesAddedDuringthePeriod" xlink:label="loc_agnc_TradingSecuritiesAddedDuringthePeriod_197A4ADC6FF45619B4BA1A799D6B20C4" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_TradingSecuritiesAddedDuringthePeriod_197A4ADC6FF45619B4BA1A799D6B20C4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" xlink:label="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_7704DC4EA7F8553CA644A0D9592C2526" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod_7704DC4EA7F8553CA644A0D9592C2526" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecurities" xlink:label="loc_us-gaap_TradingSecurities_6D044F916E7A57D9B8358B7F304D9646" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B2663742E3DE547696735A14AD182B57" xlink:to="loc_us-gaap_TradingSecurities_6D044F916E7A57D9B8358B7F304D9646" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_87881C31F5CB5D548F3F80654819C5BD" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_87881C31F5CB5D548F3F80654819C5BD" xlink:to="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_28CD116517675F2AADBF962AEFCB1DEB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:to="loc_agnc_DerivativePositionAxis_28CD116517675F2AADBF962AEFCB1DEB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_6CE3C08EE0915B0998918556C09B3F38" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_28CD116517675F2AADBF962AEFCB1DEB" xlink:to="loc_agnc_DerivativePositionDomain_6CE3C08EE0915B0998918556C09B3F38" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_9AA3FF67908554B38E65778F9B679A9C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_9AA3FF67908554B38E65778F9B679A9C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_F611D94761E85E1B849ECB6B7BA1C3F6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_9AA3FF67908554B38E65778F9B679A9C" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_F611D94761E85E1B849ECB6B7BA1C3F6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:label="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_AEC949FCE6ED50C7B5ED7CD3704BDDFE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_F611D94761E85E1B849ECB6B7BA1C3F6" xlink:to="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_AEC949FCE6ED50C7B5ED7CD3704BDDFE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_9BD19A36083F50C784974700F8276DE6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_9BD19A36083F50C784974700F8276DE6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_5FBC215DBFE853CA8A16572E52B68954" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_9BD19A36083F50C784974700F8276DE6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_5FBC215DBFE853CA8A16572E52B68954" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_F5A1D9AC4B875230AC101087C0F448C2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_5FBC215DBFE853CA8A16572E52B68954" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_F5A1D9AC4B875230AC101087C0F448C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_A25AD9DDF44955D7AAE6A8AD24D85AB1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:to="loc_us-gaap_InvestmentTypeAxis_A25AD9DDF44955D7AAE6A8AD24D85AB1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_0D3F56CEB4355413A2611F362D29A352" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_A25AD9DDF44955D7AAE6A8AD24D85AB1" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_0D3F56CEB4355413A2611F362D29A352" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_BermudanMember" xlink:label="loc_agnc_BermudanMember_519C5443DA8C534089A911ED438B52B3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_0D3F56CEB4355413A2611F362D29A352" xlink:to="loc_agnc_BermudanMember_519C5443DA8C534089A911ED438B52B3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_20DE8C69E7D45BAA8241C826CD9828D3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_0D3F56CEB4355413A2611F362D29A352" xlink:to="loc_agnc_OtherDerivativesMember_20DE8C69E7D45BAA8241C826CD9828D3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_2EF080387D5D587CBBFA6779733E75B6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:to="loc_agnc_DerivativesByMaturityAxis_2EF080387D5D587CBBFA6779733E75B6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_0ADF9D6EABA45E43A2BB50B154568175" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_2EF080387D5D587CBBFA6779733E75B6" xlink:to="loc_agnc_DerivativesByMaturityDomain_0ADF9D6EABA45E43A2BB50B154568175" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_LessThanOrEqualToOneYearMember" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_5CB37F725D975E38ADA2A0079602CB06" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_0ADF9D6EABA45E43A2BB50B154568175" xlink:to="loc_agnc_LessThanOrEqualToOneYearMember_5CB37F725D975E38ADA2A0079602CB06" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" xlink:label="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_FA833096B66058D7AC6EB307F4DC3B65" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_0ADF9D6EABA45E43A2BB50B154568175" xlink:to="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_FA833096B66058D7AC6EB307F4DC3B65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_70894731060E59ADB066F9044A39ADE9" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_70894731060E59ADB066F9044A39ADE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_52296B410A8F5B6993AB6E02117EBA7C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_70894731060E59ADB066F9044A39ADE9" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_52296B410A8F5B6993AB6E02117EBA7C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_257D4C63E2F8555E9ED1BA677246E883" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_52296B410A8F5B6993AB6E02117EBA7C" xlink:to="loc_us-gaap_ForwardContractsMember_257D4C63E2F8555E9ED1BA677246E883" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_A73C05197AC351DFAC2AAD219BC8D981" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_52296B410A8F5B6993AB6E02117EBA7C" xlink:to="loc_us-gaap_InterestRateSwaptionMember_A73C05197AC351DFAC2AAD219BC8D981" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PayerSwaptionMember" xlink:label="loc_agnc_PayerSwaptionMember_1E177DD57AB350AA853671CA0AAA311E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_52296B410A8F5B6993AB6E02117EBA7C" xlink:to="loc_agnc_PayerSwaptionMember_1E177DD57AB350AA853671CA0AAA311E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_9E9DEE414C4A507E896E424C4A5B5828" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_52296B410A8F5B6993AB6E02117EBA7C" xlink:to="loc_us-gaap_InterestRateSwapMember_9E9DEE414C4A507E896E424C4A5B5828" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F26CAE8C5EC0598AA27FB8297C5878AC" xlink:to="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:label="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_02D04F66487759B183E13F88803B0C70" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_02D04F66487759B183E13F88803B0C70" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageForwardStartDate" xlink:label="loc_agnc_WeightedAverageForwardStartDate_D7B9E658B708505683A5144D7DCD1B62" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_agnc_WeightedAverageForwardStartDate_D7B9E658B708505683A5144D7DCD1B62" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_88D9BDB1F71F5F28ADB179D88EEA6FFE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_88D9BDB1F71F5F28ADB179D88EEA6FFE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_35A83AA1CBDF5E0C8D33EDBAF04084CB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_agnc_OptionsAtCost_35A83AA1CBDF5E0C8D33EDBAF04084CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_A2C18379636950F8836A23AFF8EF854C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_A2C18379636950F8836A23AFF8EF854C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_2BEC1D8BEE9D5DD594D4386BCF78F3BE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_2BEC1D8BEE9D5DD594D4386BCF78F3BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_DFC8201AD48550F3815F4E0FA417CA13" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_DFC8201AD48550F3815F4E0FA417CA13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_65C0A5DD3C425AFE95579E48614A6C47" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_65C0A5DD3C425AFE95579E48614A6C47" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_4B412F99995655B4A7D33DB0EAE80BB1" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_4B412F99995655B4A7D33DB0EAE80BB1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_60D014B2F8E05AE5926A4228833CE648" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_60D014B2F8E05AE5926A4228833CE648" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" xlink:label="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_58B84E74CE04542CBDE6888087BFEE5F" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_85092F9F15B85B3F86D4C1B4885E408D" xlink:to="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_58B84E74CE04542CBDE6888087BFEE5F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_E425C5BDE52392B4DDEFFA4A831FFE01" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_E425C5BDE52392B4DDEFFA4A831FFE01" xlink:to="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_1DFAE5829A04C222B319FA4A832013A5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_1DFAE5829A04C222B319FA4A832013A5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_B8D479D7F08C3DDDFA14FA4A8320CBE2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_1DFAE5829A04C222B319FA4A832013A5" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_B8D479D7F08C3DDDFA14FA4A8320CBE2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_078ACFC79E5AF4A471EDFA4A832010D6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_078ACFC79E5AF4A471EDFA4A832010D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_5B0AA25C0A27C6078052FA4A8321E11B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_078ACFC79E5AF4A471EDFA4A832010D6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_5B0AA25C0A27C6078052FA4A8321E11B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_E17C510A9E93E9947834FA4A83215DC1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_5B0AA25C0A27C6078052FA4A8321E11B" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_E17C510A9E93E9947834FA4A83215DC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_464DDD83BD8AA4C73E2FFA4A83216865" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_us-gaap_InvestmentTypeAxis_464DDD83BD8AA4C73E2FFA4A83216865" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_FC0B3ECEEC9F33241E65FA4A83225E5E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_464DDD83BD8AA4C73E2FFA4A83216865" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_FC0B3ECEEC9F33241E65FA4A83225E5E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_953AF42B5E5265D7A537FA4A832223E9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_FC0B3ECEEC9F33241E65FA4A83225E5E" xlink:to="loc_agnc_OtherDerivativesMember_953AF42B5E5265D7A537FA4A832223E9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_94AD9AFEFAA464F7D515FA4A83223630" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_agnc_DerivativesByMaturityAxis_94AD9AFEFAA464F7D515FA4A83223630" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_94AD9AFEFAA464F7D515FA4A83223630" xlink:to="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_LessThanOrEqualToOneYearMember" xlink:label="loc_agnc_LessThanOrEqualToOneYearMember_A5A11AEA3A4543A4F498FA4A83239610" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_LessThanOrEqualToOneYearMember_A5A11AEA3A4543A4F498FA4A83239610" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" xlink:label="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_DDFA61DE6DE9D12A3C26FA4A8323C120" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember_DDFA61DE6DE9D12A3C26FA4A8323C120" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" xlink:label="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_AD85D53A43752DA8742AFA4A8323B3A8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember_AD85D53A43752DA8742AFA4A8323B3A8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" xlink:label="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_116065DCD676ACB8E7EFFA4A8323DDFE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember_116065DCD676ACB8E7EFFA4A8323DDFE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_3D39F38ED761FCFA22E2FA4A83230498" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_3D39F38ED761FCFA22E2FA4A83230498" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" xlink:label="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_307AEDA87C2AFEA60A55FA4A832439F2" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember_307AEDA87C2AFEA60A55FA4A832439F2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" xlink:label="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_B49F626F425EB1076F24FA4A8324528B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember_B49F626F425EB1076F24FA4A8324528B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanTenYearsMember" xlink:label="loc_agnc_GreaterThanTenYearsMember_50DC0F382A3059436FE9FA4A8324D11C" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_616B03F6EDC627A9C064FA4A83225F17" xlink:to="loc_agnc_GreaterThanTenYearsMember_50DC0F382A3059436FE9FA4A8324D11C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_F9D5ED1719455D3DC3B0FA4A8324E3DE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_F9D5ED1719455D3DC3B0FA4A8324E3DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_EEF2F101608E0D46345CFA4A83249435" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_F9D5ED1719455D3DC3B0FA4A8324E3DE" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_EEF2F101608E0D46345CFA4A83249435" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PayerSwaptionMember" xlink:label="loc_agnc_PayerSwaptionMember_02C305F69F0D42D8E31CFA4A8325D3B5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_EEF2F101608E0D46345CFA4A83249435" xlink:to="loc_agnc_PayerSwaptionMember_02C305F69F0D42D8E31CFA4A8325D3B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_CA07BECF1E38EA175E1DFA4A83254FB9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_EEF2F101608E0D46345CFA4A83249435" xlink:to="loc_us-gaap_InterestRateSwaptionMember_CA07BECF1E38EA175E1DFA4A83254FB9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_96C1FBFA789BE6DF82B6FA4A832535F8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_EEF2F101608E0D46345CFA4A83249435" xlink:to="loc_us-gaap_ForwardContractsMember_96C1FBFA789BE6DF82B6FA4A832535F8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateSwapsExcludingForwardStartingMember" xlink:label="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_EEDC2B4B77BDB4FD4482FA4A8325FB90" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_EEF2F101608E0D46345CFA4A83249435" xlink:to="loc_agnc_InterestRateSwapsExcludingForwardStartingMember_EEDC2B4B77BDB4FD4482FA4A8325FB90" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_8BDF2974271D23B83EA9FA4A83251695" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_EEF2F101608E0D46345CFA4A83249435" xlink:to="loc_us-gaap_InterestRateSwapMember_8BDF2974271D23B83EA9FA4A83251695" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_D38E05EBF571F5900E0BFA4A832660F7" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_agnc_DerivativePositionAxis_D38E05EBF571F5900E0BFA4A832660F7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_7FA2759FE9A6A797A256FA4A8326F3B5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_D38E05EBF571F5900E0BFA4A832660F7" xlink:to="loc_agnc_DerivativePositionDomain_7FA2759FE9A6A797A256FA4A8326F3B5" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_7FA2759FE9A6A797A256FA4A8326F3B5" xlink:to="loc_us-gaap_InterestRateSwapMember_8BDF2974271D23B83EA9FA4A83251695" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_B67A2299D15FE9A2DB7FFA4A8326980E" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_B67A2299D15FE9A2DB7FFA4A8326980E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_19EE4CB481B603A1DFB8FA4A8320CA1B" xlink:to="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" xlink:label="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_3ECB822D09E1B936CDA5FA4A832DDC10" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate_3ECB822D09E1B936CDA5FA4A832DDC10" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_4C662D9C7D592C599684FA4A832E9132" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_GainLossOnOtherDebt_4C662D9C7D592C599684FA4A832E9132" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_0F1462E7B7B63B45BB68FA4A832E48D7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_0F1462E7B7B63B45BB68FA4A832E48D7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_FC5B6DF57725C696A9C5FA4A832E00CD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_FC5B6DF57725C696A9C5FA4A832E00CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageFixedInterestRate" xlink:label="loc_us-gaap_DerivativeAverageFixedInterestRate_9E1E061C68DED536ABCFFA4A832E582F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_us-gaap_DerivativeAverageFixedInterestRate_9E1E061C68DED536ABCFFA4A832E582F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" xlink:label="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_CCF554C607050A80E55AFA4A832E6C69" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate_CCF554C607050A80E55AFA4A832E6C69" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OptionsAtCost" xlink:label="loc_agnc_OptionsAtCost_FF130FD19765E935C72AFA4A832E2F04" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_OptionsAtCost_FF130FD19765E935C72AFA4A832E2F04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="loc_us-gaap_InterestRateDerivativesAtFairValueNet_FEB0DE58C34D93C993B7FA4A832FB072" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_us-gaap_InterestRateDerivativesAtFairValueNet_FEB0DE58C34D93C993B7FA4A832FB072" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" xlink:label="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_B2FB4BF7B1B734E40E66FA4A832FF06D" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration_B2FB4BF7B1B734E40E66FA4A832FF06D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageVariableInterestRate" xlink:label="loc_us-gaap_DerivativeAverageVariableInterestRate_B921C86D73ECDE0DC2FEFA4A832FCAC2" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_us-gaap_DerivativeAverageVariableInterestRate_B921C86D73ECDE0DC2FEFA4A832FCAC2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAverageRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeAverageRemainingMaturity1_57A6915566140D1DE8E0FA4A832FF22A" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_us-gaap_DerivativeAverageRemainingMaturity1_57A6915566140D1DE8E0FA4A832FF22A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageForwardStartDate" xlink:label="loc_agnc_WeightedAverageForwardStartDate_27B30375A27B526BD493FA4A83306734" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_WeightedAverageForwardStartDate_27B30375A27B526BD493FA4A83306734" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateSwapsLinkedto3MonthLIBOR" xlink:label="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_490AFAB36041E6D41346FA4A8330AF94" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_InterestRateSwapsLinkedto3MonthLIBOR_490AFAB36041E6D41346FA4A8330AF94" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate" xlink:label="loc_agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate_C2F59C4B574CD5CD8FD5FA4A833067EC" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3450F6DC75C960ABA59EFA4A832D1154" xlink:to="loc_agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate_C2F59C4B574CD5CD8FD5FA4A833067EC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_D5C2257759305213A1EFEB64D1EBE9D6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_E05314C501235A228FE771264F998470" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_D5C2257759305213A1EFEB64D1EBE9D6" xlink:to="loc_us-gaap_DerivativeTable_E05314C501235A228FE771264F998470" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_D0440F47E18354029003E282F9F80BC7" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_E05314C501235A228FE771264F998470" xlink:to="loc_us-gaap_HedgingDesignationAxis_D0440F47E18354029003E282F9F80BC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_E41BD79E3C1D5AF1BE605F8F02B41687" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_D0440F47E18354029003E282F9F80BC7" xlink:to="loc_us-gaap_HedgingDesignationDomain_E41BD79E3C1D5AF1BE605F8F02B41687" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_D4688FAC70D2569C8D4D1D92C592CE81" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_E41BD79E3C1D5AF1BE605F8F02B41687" xlink:to="loc_us-gaap_NondesignatedMember_D4688FAC70D2569C8D4D1D92C592CE81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_E05314C501235A228FE771264F998470" xlink:to="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock" xlink:label="loc_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock_5F392A2659E651EA9056EED7FFAEF30E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock_5F392A2659E651EA9056EED7FFAEF30E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_98819A665C2951F2AEA5484A4A527506" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock_98819A665C2951F2AEA5484A4A527506" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" xlink:label="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_D70323B0128159B7BBD9F9C2DC7CCE51" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock_D70323B0128159B7BBD9F9C2DC7CCE51" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" xlink:label="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_01245037E8B95BDB90E697D7CA18C7E7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock_01245037E8B95BDB90E697D7CA18C7E7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_USgovernmentsecuritiesTableTextBlock" xlink:label="loc_agnc_USgovernmentsecuritiesTableTextBlock_6108DDE7167952008C2CE6C77886E417" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_USgovernmentsecuritiesTableTextBlock_6108DDE7167952008C2CE6C77886E417" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_USGovernmentFuturesSecuritiesTableTextBlock" xlink:label="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_857E0756D7FE5417A8A1656C7B6584CD" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_USGovernmentFuturesSecuritiesTableTextBlock_857E0756D7FE5417A8A1656C7B6584CD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_3714A4939FC955BB9DE6DF7349432C08" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock_3714A4939FC955BB9DE6DF7349432C08" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock" xlink:label="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_D3DD905688F25C448124F259F1F441A5" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_E712649E78CC5651ABD8EF4EEE3D22FD" xlink:to="loc_agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock_D3DD905688F25C448124F259F1F441A5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_AE6228AFF6CD117F9BCCFA4A828B8FCF" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_AE6228AFF6CD117F9BCCFA4A828B8FCF" xlink:to="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeByMaturityYearsAxis" xlink:label="loc_agnc_DerivativeByMaturityYearsAxis_CA54FD6DB8C0A1EEE4ABFA4A828B4AC5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:to="loc_agnc_DerivativeByMaturityYearsAxis_CA54FD6DB8C0A1EEE4ABFA4A828B4AC5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeByMaturityYearsDomain" xlink:label="loc_agnc_DerivativeByMaturityYearsDomain_755722350EA30EF77C97FA4A828CBFC4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsAxis_CA54FD6DB8C0A1EEE4ABFA4A828B4AC5" xlink:to="loc_agnc_DerivativeByMaturityYearsDomain_755722350EA30EF77C97FA4A828CBFC4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A30YearMaturityMember" xlink:label="loc_agnc_A30YearMaturityMember_6362B85239EF93271964FA4A828C3880" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain_755722350EA30EF77C97FA4A828CBFC4" xlink:to="loc_agnc_A30YearMaturityMember_6362B85239EF93271964FA4A828C3880" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A15YearMaturityMember" xlink:label="loc_agnc_A15YearMaturityMember_815D71B949C98368A3DDFA4A828CF025" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeByMaturityYearsDomain_755722350EA30EF77C97FA4A828CBFC4" xlink:to="loc_agnc_A15YearMaturityMember_815D71B949C98368A3DDFA4A828CF025" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesbyIssuerAxis" xlink:label="loc_agnc_DerivativesbyIssuerAxis_622AEAB5A1B6FB999822FA4A828D15A9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:to="loc_agnc_DerivativesbyIssuerAxis_622AEAB5A1B6FB999822FA4A828D15A9" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesbyIssuerDomain" xlink:label="loc_agnc_DerivativesbyIssuerDomain_5DF883A2A7061737044DFA4A828D3C88" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerAxis_622AEAB5A1B6FB999822FA4A828D15A9" xlink:to="loc_agnc_DerivativesbyIssuerDomain_5DF883A2A7061737044DFA4A828D3C88" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_DFFFBC503A964DAED159FA4A828DD7D1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_5DF883A2A7061737044DFA4A828D3C88" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_DFFFBC503A964DAED159FA4A828DD7D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E34F2BC56BF99FDCC4F1FA4A828D7113" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_5DF883A2A7061737044DFA4A828D3C88" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E34F2BC56BF99FDCC4F1FA4A828D7113" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_6A3DEC5E36B25159F913FA4A828DCC73" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesbyIssuerDomain_5DF883A2A7061737044DFA4A828D3C88" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_6A3DEC5E36B25159F913FA4A828DCC73" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_0D8ED9D49D9FE5313786FA4A828EBE13" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:to="loc_us-gaap_PositionAxis_0D8ED9D49D9FE5313786FA4A828EBE13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_2C6D461F786B36AB05E6FA4A828E2614" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_0D8ED9D49D9FE5313786FA4A828EBE13" xlink:to="loc_us-gaap_PositionDomain_2C6D461F786B36AB05E6FA4A828E2614" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_BE4C34096EFD5D816D73FA4A828EFA84" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_2C6D461F786B36AB05E6FA4A828E2614" xlink:to="loc_us-gaap_ShortMember_BE4C34096EFD5D816D73FA4A828EFA84" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_4BCDA263C8C5BF04C9F7FA4A828EE831" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:to="loc_agnc_DerivativePositionAxis_4BCDA263C8C5BF04C9F7FA4A828EE831" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_1B8C4FDD9CACA6BD74EDFA4A828F6B0D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_4BCDA263C8C5BF04C9F7FA4A828EE831" xlink:to="loc_agnc_DerivativePositionDomain_1B8C4FDD9CACA6BD74EDFA4A828F6B0D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A2.5CouponMember" xlink:label="loc_agnc_A2.5CouponMember_5641B0479C76C9538F42FA4A828F7C0D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_1B8C4FDD9CACA6BD74EDFA4A828F6B0D" xlink:to="loc_agnc_A2.5CouponMember_5641B0479C76C9538F42FA4A828F7C0D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A3.0CouponMember" xlink:label="loc_agnc_A3.0CouponMember_BF14CB9B6C9372242E6BFA4A828F31B3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_1B8C4FDD9CACA6BD74EDFA4A828F6B0D" xlink:to="loc_agnc_A3.0CouponMember_BF14CB9B6C9372242E6BFA4A828F31B3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A3.5CouponMember" xlink:label="loc_agnc_A3.5CouponMember_56BDB2E66765356FA09BFA4A828F1116" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_1B8C4FDD9CACA6BD74EDFA4A828F6B0D" xlink:to="loc_agnc_A3.5CouponMember_56BDB2E66765356FA09BFA4A828F1116" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A4.0CouponMember" xlink:label="loc_agnc_A4.0CouponMember_C9A719E49C73A758CB72FA4A828FE09A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_1B8C4FDD9CACA6BD74EDFA4A828F6B0D" xlink:to="loc_agnc_A4.0CouponMember_C9A719E49C73A758CB72FA4A828FE09A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A4.5CouponMember" xlink:label="loc_agnc_A4.5CouponMember_B5121BC7D549A022EE04FA4A8290B2C2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_1B8C4FDD9CACA6BD74EDFA4A828F6B0D" xlink:to="loc_agnc_A4.5CouponMember_B5121BC7D549A022EE04FA4A8290B2C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_468F3074C61491A502C6FA4A8290A4E4" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_468F3074C61491A502C6FA4A8290A4E4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_468F3074C61491A502C6FA4A8290A4E4" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_4F737F2B7C5C80F82146FA4A82908C0D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_4F737F2B7C5C80F82146FA4A82908C0D" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:to="loc_agnc_A15YearMaturityMember_815D71B949C98368A3DDFA4A828CF025" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:to="loc_agnc_A30YearMaturityMember_6362B85239EF93271964FA4A828C3880" xlink:type="arc" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_6A3DEC5E36B25159F913FA4A828DCC73" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_E34F2BC56BF99FDCC4F1FA4A828D7113" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C5D7918276F29A7294A3FA4A82908583" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_DFFFBC503A964DAED159FA4A828DD7D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_87B974CF7C8D4700DBD3FA4A8297973E" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_F5F5660555DC989BD8BDFA4A828B54AA" xlink:to="loc_us-gaap_DerivativeLineItems_87B974CF7C8D4700DBD3FA4A8297973E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="loc_us-gaap_DerivativeNotionalAmount_7E311350C770FF98A937FA5085B74EF3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_87B974CF7C8D4700DBD3FA4A8297973E" xlink:to="loc_us-gaap_DerivativeNotionalAmount_7E311350C770FF98A937FA5085B74EF3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_BB95FFAE1DC54801D217FA4A8297C43E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_87B974CF7C8D4700DBD3FA4A8297973E" xlink:to="loc_agnc_DerivativeForwardSettlementValue_BB95FFAE1DC54801D217FA4A8297C43E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_E35F419967A340F81D7DFA4A8297C8BE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_87B974CF7C8D4700DBD3FA4A8297973E" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_E35F419967A340F81D7DFA4A8297C8BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_B70B92CC0933706E5381FA4A829871A8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_87B974CF7C8D4700DBD3FA4A8297973E" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_B70B92CC0933706E5381FA4A829871A8" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_551ED079DC8092EF65AFFA4A82B83C4E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_551ED079DC8092EF65AFFA4A82B83C4E" xlink:to="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_B9BCAB02C086ADFC3E0FFA4A82B9BF33" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_us-gaap_InvestmentTypeAxis_B9BCAB02C086ADFC3E0FFA4A82B9BF33" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_CE193B95BD22078090DCFA4A82B9D22C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_B9BCAB02C086ADFC3E0FFA4A82B9BF33" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_CE193B95BD22078090DCFA4A82B9D22C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_E5F861751DCF3BA9C689FA4A82B916CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_CE193B95BD22078090DCFA4A82B9D22C" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_E5F861751DCF3BA9C689FA4A82B916CA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeInstrumentsDesignationAxis" xlink:label="loc_agnc_DerivativeInstrumentsDesignationAxis_620F3D5AD920B6E8670FFA4A82B98726" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_agnc_DerivativeInstrumentsDesignationAxis_620F3D5AD920B6E8670FFA4A82B98726" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeInstrumentsDesignationDomain" xlink:label="loc_agnc_DerivativeInstrumentsDesignationDomain_8FE608D8064C006B9C33FA4A82BA1AEE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationAxis_620F3D5AD920B6E8670FFA4A82B98726" xlink:to="loc_agnc_DerivativeInstrumentsDesignationDomain_8FE608D8064C006B9C33FA4A82BA1AEE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AtCostBasisMember" xlink:label="loc_agnc_AtCostBasisMember_0A9180DDFB90EE9ECF0CFA4A82BAE151" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativeInstrumentsDesignationDomain_8FE608D8064C006B9C33FA4A82BA1AEE" xlink:to="loc_agnc_AtCostBasisMember_0A9180DDFB90EE9ECF0CFA4A82BAE151" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_4B0BFD05B9F80A435200FA4A82BAF7BD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_4B0BFD05B9F80A435200FA4A82BAF7BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_F2824042CF686C8894E7FA4A82BAA78A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_4B0BFD05B9F80A435200FA4A82BAF7BD" xlink:to="loc_us-gaap_HedgingRelationshipDomain_F2824042CF686C8894E7FA4A82BAA78A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueHedgingMember" xlink:label="loc_us-gaap_FairValueHedgingMember_C5674C432DAA6EBADC15FA4A82BB3782" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingRelationshipDomain_F2824042CF686C8894E7FA4A82BAA78A" xlink:to="loc_us-gaap_FairValueHedgingMember_C5674C432DAA6EBADC15FA4A82BB3782" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionAxis" xlink:label="loc_us-gaap_PositionAxis_A25AB9B2F299D5EE6BC5FA4A82BBF5F2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_us-gaap_PositionAxis_A25AB9B2F299D5EE6BC5FA4A82BBF5F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositionDomain" xlink:label="loc_us-gaap_PositionDomain_9063338808CF97120F2BFA4A82BBB8B5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionAxis_A25AB9B2F299D5EE6BC5FA4A82BBF5F2" xlink:to="loc_us-gaap_PositionDomain_9063338808CF97120F2BFA4A82BBB8B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortMember" xlink:label="loc_us-gaap_ShortMember_E936DD1C2FADD96B410CFA4A82C1C985" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_9063338808CF97120F2BFA4A82BBB8B5" xlink:to="loc_us-gaap_ShortMember_E936DD1C2FADD96B410CFA4A82C1C985" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongMember" xlink:label="loc_us-gaap_LongMember_20B848339E2DD6225645FA4A82C13F00" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PositionDomain_9063338808CF97120F2BFA4A82BBB8B5" xlink:to="loc_us-gaap_LongMember_20B848339E2DD6225645FA4A82C13F00" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesByMaturityAxis" xlink:label="loc_agnc_DerivativesByMaturityAxis_A2CA8EFB061541385FC8FA4A82C120F7" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_agnc_DerivativesByMaturityAxis_A2CA8EFB061541385FC8FA4A82C120F7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativesByMaturityDomain" xlink:label="loc_agnc_DerivativesByMaturityDomain_74E4DE5166FD80A6D965FA4A82C1312D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityAxis_A2CA8EFB061541385FC8FA4A82C120F7" xlink:to="loc_agnc_DerivativesByMaturityDomain_74E4DE5166FD80A6D965FA4A82C1312D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A10YearMaturityMember" xlink:label="loc_agnc_A10YearMaturityMember_EFAFAC98E90BF831C309FA4A82C26D2B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_74E4DE5166FD80A6D965FA4A82C1312D" xlink:to="loc_agnc_A10YearMaturityMember_EFAFAC98E90BF831C309FA4A82C26D2B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A5YearMaturityMember" xlink:label="loc_agnc_A5YearMaturityMember_91E5D567FF596570259BFA4A82C22D54" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativesByMaturityDomain_74E4DE5166FD80A6D965FA4A82C1312D" xlink:to="loc_agnc_A5YearMaturityMember_91E5D567FF596570259BFA4A82C22D54" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionAxis" xlink:label="loc_agnc_DerivativePositionAxis_3C0A4D963AD12120585FFA4A82C226FC" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_agnc_DerivativePositionAxis_3C0A4D963AD12120585FFA4A82C226FC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativePositionDomain" xlink:label="loc_agnc_DerivativePositionDomain_BB4A599415F2DE3E41D2FA4A82C258C3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionAxis_3C0A4D963AD12120585FFA4A82C226FC" xlink:to="loc_agnc_DerivativePositionDomain_BB4A599415F2DE3E41D2FA4A82C258C3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A2.5CouponMember" xlink:label="loc_agnc_A2.5CouponMember_CC5E61255E0AAD185825FA4A82C3DD99" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DerivativePositionDomain_BB4A599415F2DE3E41D2FA4A82C258C3" xlink:to="loc_agnc_A2.5CouponMember_CC5E61255E0AAD185825FA4A82C3DD99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_6366DA6122B4BE97EE7FFA4A82C3B425" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_6366DA6122B4BE97EE7FFA4A82C3B425" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_6366DA6122B4BE97EE7FFA4A82C3B425" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A7YearsMaturityMember" xlink:label="loc_agnc_A7YearsMaturityMember_03F473F558350F5D903BFA4A82C36870" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_agnc_A7YearsMaturityMember_03F473F558350F5D903BFA4A82C36870" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_04B5E5B3C854A273B16BFA4A82C49774" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_us-gaap_FutureMember_04B5E5B3C854A273B16BFA4A82C49774" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A15YearMaturityMember" xlink:label="loc_agnc_A15YearMaturityMember_FFD822AD2C9ABDC48C2EFA4A82C463D1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_agnc_A15YearMaturityMember_FFD822AD2C9ABDC48C2EFA4A82C463D1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AtParValueMember" xlink:label="loc_agnc_AtParValueMember_83E35A256A8E63C9919FFA4A82C4CC1F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_agnc_AtParValueMember_83E35A256A8E63C9919FFA4A82C4CC1F" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_agnc_AtCostBasisMember_0A9180DDFB90EE9ECF0CFA4A82BAE151" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_E5F861751DCF3BA9C689FA4A82B916CA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_569A9998EC254B750645FA4A82C5F96E" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_569A9998EC254B750645FA4A82C5F96E" xlink:type="arc" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_agnc_A5YearMaturityMember_91E5D567FF596570259BFA4A82C22D54" xlink:type="arc" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_27A45234FB24AAFFD766FA4A82C30F09" xlink:to="loc_agnc_A10YearMaturityMember_EFAFAC98E90BF831C309FA4A82C26D2B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_CB0AA16DE18023F9EC2DFA4A82B810A4" xlink:to="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="loc_us-gaap_DerivativeNotionalAmount_FBC88AAA4158224F4B3BFA4FB8FA8733" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:to="loc_us-gaap_DerivativeNotionalAmount_FBC88AAA4158224F4B3BFA4FB8FA8733" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_8026BB8A55F419D9A826FA4A82C648BC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:to="loc_agnc_DerivativeForwardSettlementValue_8026BB8A55F419D9A826FA4A82C648BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_B2B3D2DD3F2CCA1BB1B8FA4A82C6A11F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_B2B3D2DD3F2CCA1BB1B8FA4A82C6A11F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_B218043D3DFB761D0957FA4A82C68B12" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_B218043D3DFB761D0957FA4A82C68B12" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Governmentbondsownedandsoldshortnet" xlink:label="loc_agnc_Governmentbondsownedandsoldshortnet_970A023680BAF3A78DA2FA4A82C6A520" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:to="loc_agnc_Governmentbondsownedandsoldshortnet_970A023680BAF3A78DA2FA4A82C6A520" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageYieldPercentage" xlink:label="loc_agnc_WeightedAverageYieldPercentage_CAC020F3A437E2056521FA4A82C695DF" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_06A9C8DCBFDBD64F749BFA4A82C50520" xlink:to="loc_agnc_WeightedAverageYieldPercentage_CAC020F3A437E2056521FA4A82C695DF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DocumentAndEntityInformationAbstract" xlink:label="loc_agnc_DocumentAndEntityInformationAbstract_4AAC1C2718C88AE408DEFB1816C53060" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntitiesTable" xlink:label="loc_dei_EntitiesTable_0935C8109291EA26C7A7FB1816C55C43" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_DocumentAndEntityInformationAbstract_4AAC1C2718C88AE408DEFB1816C53060" xlink:to="loc_dei_EntitiesTable_0935C8109291EA26C7A7FB1816C55C43" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_A840825589D00B2BBC4BFB1816C674D8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_0935C8109291EA26C7A7FB1816C55C43" xlink:to="loc_us-gaap_StatementClassOfStockAxis_A840825589D00B2BBC4BFB1816C674D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_A840825589D00B2BBC4BFB1816C674D8" xlink:to="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_5CEEF7E6471EFCDD02A5FB1816C6A6BB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:to="loc_us-gaap_CommonStockMember_5CEEF7E6471EFCDD02A5FB1816C6A6BB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_B66C83AF203DAA120563FB1816C66ABE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.750SeriesBCumulativeRedeemablePreferredStockMember_B66C83AF203DAA120563FB1816C66ABE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_36AE24A4BAB35A264D53FB1816C776FE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof7.000SeriesCFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_36AE24A4BAB35A264D53FB1816C776FE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_726FB079B1C52A1E5E5EFB1816C762C2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_726FB079B1C52A1E5E5EFB1816C762C2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_1A185ED2B7995099ACADFB1816C79BCB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:to="loc_agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.500SeriesEFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_1A185ED2B7995099ACADFB1816C79BCB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" xlink:label="loc_agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_368E731684FCD2029855FB1816C7213A" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4D3440178250389DB866FB1816C6784B" xlink:to="loc_agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember_368E731684FCD2029855FB1816C7213A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_21D4D3703AD905E1436AFB1816C8EEDB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_0935C8109291EA26C7A7FB1816C55C43" xlink:to="loc_dei_LegalEntityAxis_21D4D3703AD905E1436AFB1816C8EEDB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_7EA4CF75E3036E64254FFB1816C85A1A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_21D4D3703AD905E1436AFB1816C8EEDB" xlink:to="loc_dei_EntityDomain_7EA4CF75E3036E64254FFB1816C85A1A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityInformationLineItems" xlink:label="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_0935C8109291EA26C7A7FB1816C55C43" xlink:to="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle" xlink:label="loc_dei_Security12bTitle_C5E69D80F4DA3BAA1DE8FB1816C8D8C8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_Security12bTitle_C5E69D80F4DA3BAA1DE8FB1816C8D8C8" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="loc_dei_EntityIncorporationStateCountryCode_BAA37505792E814D220AFB1816C9BA4C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityIncorporationStateCountryCode_BAA37505792E814D220AFB1816C9BA4C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentTransitionReport" xlink:label="loc_dei_DocumentTransitionReport_761D82C4F45B016E08F7FB1816C9A14C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_DocumentTransitionReport_761D82C4F45B016E08F7FB1816C9A14C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentQuarterlyReport" xlink:label="loc_dei_DocumentQuarterlyReport_F1E745445B493DDF4E06FB181AA4AAAB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_DocumentQuarterlyReport_F1E745445B493DDF4E06FB181AA4AAAB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber" xlink:label="loc_dei_EntityTaxIdentificationNumber_925AA84C6ECB2EE3B7D2FB1816C9EE48" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityTaxIdentificationNumber_925AA84C6ECB2EE3B7D2FB1816C9EE48" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_5DA9790F8E73D14581BAFB1816C9FFD4" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_DocumentType_5DA9790F8E73D14581BAFB1816C9FFD4" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_81FC727675A5424E2995FB1816C951BD" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_AmendmentFlag_81FC727675A5424E2995FB1816C951BD" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_F3FA1C88D363A378B2DAFB1816C9BAF2" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_DocumentPeriodEndDate_F3FA1C88D363A378B2DAFB1816C9BAF2" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber" xlink:label="loc_dei_EntityFileNumber_FA46DF2CF0C9CD1DE09FFB1816CFC3A5" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityFileNumber_FA46DF2CF0C9CD1DE09FFB1816CFC3A5" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_E0FE7A393D0206A532A4FB1816CFD0C0" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_DocumentFiscalYearFocus_E0FE7A393D0206A532A4FB1816CFD0C0" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_BAE538FD5FFC8AD762C6FB1816D0D06C" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_DocumentFiscalPeriodFocus_BAE538FD5FFC8AD762C6FB1816D0D06C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_10E0F77892CB4543DC88FB1816D0C911" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityRegistrantName_10E0F77892CB4543DC88FB1816D0C911" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1" xlink:label="loc_dei_EntityAddressAddressLine1_6D91F7C51A086747F7A8FB1816D08FEE" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityAddressAddressLine1_6D91F7C51A086747F7A8FB1816D08FEE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown" xlink:label="loc_dei_EntityAddressCityOrTown_1E1A2D392640678C17BEFB1816D03B96" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityAddressCityOrTown_1E1A2D392640678C17BEFB1816D03B96" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince" xlink:label="loc_dei_EntityAddressStateOrProvince_1E733C2A7A08596CA13DFB1816D06D04" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityAddressStateOrProvince_1E733C2A7A08596CA13DFB1816D06D04" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode" xlink:label="loc_dei_EntityAddressPostalZipCode_BBD4123B4E860EFE3D40FB1816D0CF2E" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityAddressPostalZipCode_BBD4123B4E860EFE3D40FB1816D0CF2E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode" xlink:label="loc_dei_CityAreaCode_78F79E196BDEEDE97CEEFB1816D01357" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_CityAreaCode_78F79E196BDEEDE97CEEFB1816D01357" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber" xlink:label="loc_dei_LocalPhoneNumber_7114977FC95CC8FC261EFB1816D1653F" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_LocalPhoneNumber_7114977FC95CC8FC261EFB1816D1653F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_3CCD72BF4D73A429776CFB1816D19367" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityCentralIndexKey_3CCD72BF4D73A429776CFB1816D19367" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_21EA0C8302D0E76B3301FB1816D136A0" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityFilerCategory_21EA0C8302D0E76B3301FB1816D136A0" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntitySmallBusiness" xlink:label="loc_dei_EntitySmallBusiness_1A2E6D809A72C95C9B14FB1816D15735" xlink:type="locator" />
    <link:presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntitySmallBusiness_1A2E6D809A72C95C9B14FB1816D15735" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_9AEB6ECD9187AFA706C0FB1816D147E1" xlink:type="locator" />
    <link:presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityEmergingGrowthCompany_9AEB6ECD9187AFA706C0FB1816D147E1" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_32182F58B9B11BE52AB7FB1816D26EBC" xlink:type="locator" />
    <link:presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_CurrentFiscalYearEndDate_32182F58B9B11BE52AB7FB1816D26EBC" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_9838094552512553DF3BFB1816D2A50C" xlink:type="locator" />
    <link:presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_9838094552512553DF3BFB1816D2A50C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol" xlink:label="loc_dei_TradingSymbol_B5E7015A6ADFF3A04790FB1816D2E742" xlink:type="locator" />
    <link:presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_TradingSymbol_B5E7015A6ADFF3A04790FB1816D2E742" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName" xlink:label="loc_dei_SecurityExchangeName_0CCF241BCF58B1AC73D0FB1816D2A962" xlink:type="locator" />
    <link:presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_SecurityExchangeName_0CCF241BCF58B1AC73D0FB1816D2A962" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_BBFAFCB3B7072963E7E0FB1816D26DF6" xlink:type="locator" />
    <link:presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_BBFAFCB3B7072963E7E0FB1816D26DF6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_19040A723EE3F0CE6F99FB1816D346B9" xlink:type="locator" />
    <link:presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityVoluntaryFilers_19040A723EE3F0CE6F99FB1816D346B9" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_D555AD4D4DA03550395DFB1816D36535" xlink:type="locator" />
    <link:presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityCurrentReportingStatus_D555AD4D4DA03550395DFB1816D36535" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityInteractiveDataCurrent" xlink:label="loc_dei_EntityInteractiveDataCurrent_7C913AD454EE6E2ACBEFFB1816D3B4AD" xlink:type="locator" />
    <link:presentationArc order="30" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityInteractiveDataCurrent_7C913AD454EE6E2ACBEFFB1816D3B4AD" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityShellCompany" xlink:label="loc_dei_EntityShellCompany_11DF023624F90F4862F8FB1816D3C066" xlink:type="locator" />
    <link:presentationArc order="31" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityShellCompany_11DF023624F90F4862F8FB1816D3C066" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_A93A869BDEF763DDFD97FB1816D3E2F7" xlink:type="locator" />
    <link:presentationArc order="32" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_93C22572BDBFBE1F5380FB1816C8EF8B" xlink:to="loc_dei_EntityPublicFloat_A93A869BDEF763DDFD97FB1816D3E2F7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_43ABF22D506B559BB8AC7FDBF4DBD705" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_1E2EC1AAB7245A31B3915A22A7836129" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_43ABF22D506B559BB8AC7FDBF4DBD705" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_1E2EC1AAB7245A31B3915A22A7836129" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_A9C426598BF36D8AD1AAFB17063B4484" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_A9C426598BF36D8AD1AAFB17063B4484" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_E0BCD6AEA24B78E8F8E2FB17063CC65A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_E0BCD6AEA24B78E8F8E2FB17063CC65A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_8B93C1FF9DC131B2B376FB17063C0890" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_E0BCD6AEA24B78E8F8E2FB17063CC65A" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_8B93C1FF9DC131B2B376FB17063C0890" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FutureMember" xlink:label="loc_us-gaap_FutureMember_C980318428D0E58BB2F0FB17063C3BB3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8B93C1FF9DC131B2B376FB17063C0890" xlink:to="loc_us-gaap_FutureMember_C980318428D0E58BB2F0FB17063C3BB3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_81ED34DA2B395DAB55A7FB17063DB5E1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8B93C1FF9DC131B2B376FB17063C0890" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_81ED34DA2B395DAB55A7FB17063DB5E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwaptionMember" xlink:label="loc_us-gaap_InterestRateSwaptionMember_1B64A4D145FEF1F9DAE4FB17063D2296" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8B93C1FF9DC131B2B376FB17063C0890" xlink:to="loc_us-gaap_InterestRateSwaptionMember_1B64A4D145FEF1F9DAE4FB17063D2296" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_960A50CF5101ABB22D40FB17063D8640" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8B93C1FF9DC131B2B376FB17063C0890" xlink:to="loc_us-gaap_InterestRateSwapMember_960A50CF5101ABB22D40FB17063D8640" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_37A9CF24ACB673982B1FFB17063D0DAF" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8B93C1FF9DC131B2B376FB17063C0890" xlink:to="loc_agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember_37A9CF24ACB673982B1FFB17063D0DAF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_7248E8BD76D26D3670C9FB17063D1A59" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_E0BCD6AEA24B78E8F8E2FB17063CC65A" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_7248E8BD76D26D3670C9FB17063D1A59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_7CE9FA5BCDC3BFE720F6FB17063F2625" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_7CE9FA5BCDC3BFE720F6FB17063F2625" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_B7DB9040761B7320D476FB17063FE3B0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_7CE9FA5BCDC3BFE720F6FB17063F2625" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_B7DB9040761B7320D476FB17063FE3B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember" xlink:label="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_F5E32EAE19192DC12681FB17063F954F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_B7DB9040761B7320D476FB17063FE3B0" xlink:to="loc_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_F5E32EAE19192DC12681FB17063F954F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6A4AD0AEDE1391E2D567FB17063F78BC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6A4AD0AEDE1391E2D567FB17063F78BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_30F21DD29138D0858208FB170640B843" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6A4AD0AEDE1391E2D567FB17063F78BC" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_30F21DD29138D0858208FB170640B843" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_5B06E3C59E3FF9F0DE75FB170640499E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_30F21DD29138D0858208FB170640B843" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_5B06E3C59E3FF9F0DE75FB170640499E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_62083C58F9C071B9EEDAFB1706405F8D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_62083C58F9C071B9EEDAFB1706405F8D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F5997B497ADA0ADBEA25FB1706403D23" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_62083C58F9C071B9EEDAFB1706405F8D" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F5997B497ADA0ADBEA25FB1706403D23" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_205E3ADCF9EAA40AA760FB17064110E1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F5997B497ADA0ADBEA25FB1706403D23" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_205E3ADCF9EAA40AA760FB17064110E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_D718DBB54A1F35BA0464FB170641FE6D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F5997B497ADA0ADBEA25FB1706403D23" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_D718DBB54A1F35BA0464FB170641FE6D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_905C33586332AF08121FFB170641502E" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_905C33586332AF08121FFB170641502E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_905C33586332AF08121FFB170641502E" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OtherDerivativesMember" xlink:label="loc_agnc_OtherDerivativesMember_F8AFD9C813430B534C7EFB1706422DAC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:to="loc_agnc_OtherDerivativesMember_F8AFD9C813430B534C7EFB1706422DAC" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:to="loc_us-gaap_InterestRateSwapMember_960A50CF5101ABB22D40FB17063D8640" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_4A848507D63D397AD8C5FB170642E1E4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_4A848507D63D397AD8C5FB170642E1E4" xlink:type="arc" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:to="loc_us-gaap_FutureMember_C980318428D0E58BB2F0FB17063C3BB3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_09DBB9E38F14A59A751CFB170642D0B1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:to="loc_agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember_09DBB9E38F14A59A751CFB170642D0B1" xlink:type="arc" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_FD13E0C16BD8B6590376FB170641CFEC" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_81ED34DA2B395DAB55A7FB17063DB5E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_6C05C0979CEA27BEB8FAFB1706483ADE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_6C05C0979CEA27BEB8FAFB1706483ADE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_FDA001FB012113498D71FB17064806D9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_6C05C0979CEA27BEB8FAFB1706483ADE" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_FDA001FB012113498D71FB17064806D9" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_FDA001FB012113498D71FB17064806D9" xlink:to="loc_us-gaap_InterestRateSwapMember_960A50CF5101ABB22D40FB17063D8640" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_46538D15504A47AAF945FB17063B12F2" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure" xlink:label="loc_us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_3F76D6F0E2D245BD624DFB170648E2FB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_SecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_3F76D6F0E2D245BD624DFB170648E2FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_0459903D635AF7BD26C0FB170649B907" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_0459903D635AF7BD26C0FB170649B907" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TransfersBetweenHierarchyLevels" xlink:label="loc_agnc_TransfersBetweenHierarchyLevels_237E7E88160CA8BEC850FB170649A24F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_agnc_TransfersBetweenHierarchyLevels_237E7E88160CA8BEC850FB170649A24F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_C0BC5C74A61798CF67BBFB17064921D7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_C0BC5C74A61798CF67BBFB17064921D7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_3DCE18BEA16D414845C0FB17064A193A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_3DCE18BEA16D414845C0FB17064A193A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NonAgencySecuritiesatFairValue" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_05253E72B77790B32FDCFB17064A93C1" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_05253E72B77790B32FDCFB17064A93C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F3A544423CAD4A9285E3FB17064A86BD" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_F3A544423CAD4A9285E3FB17064A86BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_39E9F2FFE96628356D0DFB17064A7B36" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_39E9F2FFE96628356D0DFB17064A7B36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_2149C4EA87BB6AA185A5FB17064B3A25" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_2149C4EA87BB6AA185A5FB17064B3A25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_3323CC7494BDA5C6777AFB17064B08AA" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_DerivativeAssets_3323CC7494BDA5C6777AFB17064B08AA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_5F745DA8268D9545ECCFFB17064BCD6B" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_DerivativeLiabilities_5F745DA8268D9545ECCFFB17064BCD6B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_C967F5C21C4649BD6EC9FB17064B7F2B" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_C967F5C21C4649BD6EC9FB17064B7F2B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_1E2D4C48884374A73AE6FB17064BEA46" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_OtherLongTermDebt_1E2D4C48884374A73AE6FB17064BEA46" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_9278B4642DF61F79EAA7FB17064C5AEB" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_9278B4642DF61F79EAA7FB17064C5AEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_50B8488CCCE79099B5F9FB17064CF3FB" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAssetAtFairValue_50B8488CCCE79099B5F9FB17064CF3FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_8B6629983D215B75D855FB17064CEA89" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5F714128AF59AD5D9177FB1706486543" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_8B6629983D215B75D855FB17064CEA89" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_8EDA24462A0653A48623BE468623EFC3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_B7FD5D72C0E558AFB2B00B292424A30F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_8EDA24462A0653A48623BE468623EFC3" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_B7FD5D72C0E558AFB2B00B292424A30F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecurities" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_84F2AD784C605AA0B25DA1637714FADB" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InvestmentInMortgageBackedSecuritiesTextBlock" xlink:label="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_70CF5E52E209565D9DAC7EEE2D9A8CF5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_84F2AD784C605AA0B25DA1637714FADB" xlink:to="loc_agnc_InvestmentInMortgageBackedSecuritiesTextBlock_70CF5E52E209565D9DAC7EEE2D9A8CF5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_4084F2DF7688BF54C760FB1D32FDFE8F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable_A6A32D95E30F77E0104FFB1D32FE6B2D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_4084F2DF7688BF54C760FB1D32FDFE8F" xlink:to="loc_us-gaap_ScheduleOfInvestmentsTable_A6A32D95E30F77E0104FFB1D32FE6B2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_E0AFE72419A2511FF82DFB1D32FE5DA6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_A6A32D95E30F77E0104FFB1D32FE6B2D" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_E0AFE72419A2511FF82DFB1D32FE5DA6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_110A58A4EEFD67A9DB33FB1D32FFE812" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_E0AFE72419A2511FF82DFB1D32FE5DA6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_110A58A4EEFD67A9DB33FB1D32FFE812" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_4E3D6358EC36376404DFFB1D32FFC07D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_110A58A4EEFD67A9DB33FB1D32FFE812" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_4E3D6358EC36376404DFFB1D32FFC07D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_85E197A1B0276C0C59ADFB1D32FFA6FF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_A6A32D95E30F77E0104FFB1D32FE6B2D" xlink:to="loc_us-gaap_InvestmentTypeAxis_85E197A1B0276C0C59ADFB1D32FFA6FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_85E197A1B0276C0C59ADFB1D32FFA6FF" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember" xlink:label="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_5C836161D9E5EA67B893FB1D33007953" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:to="loc_us-gaap_FederalNationalMortgageAssociationCertificatesAndObligationsFNMAMember_5C836161D9E5EA67B893FB1D33007953" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember" xlink:label="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_4ABE5EC9CB9FAFAE80B6FB1D33001636" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:to="loc_us-gaap_FederalHomeLoanMortgageCorporationCertificatesAndObligationsFHLMCMember_4ABE5EC9CB9FAFAE80B6FB1D33001636" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember" xlink:label="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_38684C5B72F2BBC1BE3DFB1D3300AF33" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:to="loc_us-gaap_GovernmentNationalMortgageAssociationCertificatesAndObligationsGNMAMember_38684C5B72F2BBC1BE3DFB1D3300AF33" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_8B87182A0CB395B45601FB1D33005285" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_8B87182A0CB395B45601FB1D33005285" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_BD1046F46B5699F8476EFB1D33014E8E" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_BD1046F46B5699F8476EFB1D33014E8E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_8BD57DBF9447D157A8E8FB1D3301B86B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_F2CC34FDF06B3B09D93CFB1D32FF3CAB" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_8BD57DBF9447D157A8E8FB1D3301B86B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_80B68F8941FED2BA8646FB1D3301026D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_A6A32D95E30F77E0104FFB1D32FE6B2D" xlink:to="loc_us-gaap_FinancialInstrumentAxis_80B68F8941FED2BA8646FB1D3301026D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0A634D391964CA92667DFB1D33014563" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_80B68F8941FED2BA8646FB1D3301026D" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0A634D391964CA92667DFB1D33014563" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_4D65772E07BA3B40125BFB1D33022D87" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0A634D391964CA92667DFB1D33014563" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_4D65772E07BA3B40125BFB1D33022D87" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TradingSecuritiesMember" xlink:label="loc_agnc_TradingSecuritiesMember_FEC3E71C2C07E90B520BFB1D3302B5C2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0A634D391964CA92667DFB1D33014563" xlink:to="loc_agnc_TradingSecuritiesMember_FEC3E71C2C07E90B520BFB1D3302B5C2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SecuritiesRemeasuredatFairValueMember" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_5531A9C7FA0AF05EB050FB1D33023936" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0A634D391964CA92667DFB1D33014563" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_5531A9C7FA0AF05EB050FB1D33023936" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_A6A32D95E30F77E0104FFB1D32FE6B2D" xlink:to="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_5ACC2AE3BDE3A5C83566FB1D3302F1FC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_5ACC2AE3BDE3A5C83566FB1D3302F1FC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AvailableForSaleSecuritiesPar" xlink:label="loc_agnc_AvailableForSaleSecuritiesPar_AD3CD9F9CC0EAFA35A6DFB1D33036B00" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_agnc_AvailableForSaleSecuritiesPar_AD3CD9F9CC0EAFA35A6DFB1D33036B00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_20F4F42A3CF3C90ADF6CFB1D33034E16" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_20F4F42A3CF3C90ADF6CFB1D33034E16" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium_A1716336FF50AF142D1FFB1D3303FE78" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedPremium_A1716336FF50AF142D1FFB1D3303FE78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingUnrealizedGain" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedGain_59DB2656840814E0AF4AFB1D330413D1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_DebtSecuritiesTradingUnrealizedGain_59DB2656840814E0AF4AFB1D330413D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingUnrealizedLoss" xlink:label="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss_F59B8C013EC0D790492FFB1D33045E81" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_DebtSecuritiesTradingUnrealizedLoss_F59B8C013EC0D790492FFB1D33045E81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecuritiesDebt" xlink:label="loc_us-gaap_TradingSecuritiesDebt_4593B9401BC239DDB4FBFB1D33048765" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_TradingSecuritiesDebt_4593B9401BC239DDB4FBFB1D33048765" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_2B48BD79AB26EBD6F15FFB1D33043C56" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_2B48BD79AB26EBD6F15FFB1D33043C56" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_47C7F898D22B2AC9CE34FB1D3305A027" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_47C7F898D22B2AC9CE34FB1D3305A027" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecuritiesCost" xlink:label="loc_us-gaap_TradingSecuritiesCost_DB96E8824534724CDF9BFB1D33056E31" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_TradingSecuritiesCost_DB96E8824534724CDF9BFB1D33056E31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_E3A20F25667070AF9320FB1D3305513D" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGains_E3A20F25667070AF9320FB1D3305513D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_9A7E4EEA34936AB009E7FB1D33053E59" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLoss_9A7E4EEA34936AB009E7FB1D33053E59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_066B461F10874BC6E5B9FB1D3306C7D6" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_066B461F10874BC6E5B9FB1D3306C7D6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TradingSecuritiesPar" xlink:label="loc_agnc_TradingSecuritiesPar_2BCAD257A4C8354CB79EFB1D3306D85F" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_agnc_TradingSecuritiesPar_2BCAD257A4C8354CB79EFB1D3306D85F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_C4C01650905FBCF76CA0FB1D3306DE2D" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_C4C01650905FBCF76CA0FB1D3306DE2D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageYieldPercentage" xlink:label="loc_agnc_WeightedAverageYieldPercentage_E60424485B1757B01106FB1D33067F6F" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_agnc_WeightedAverageYieldPercentage_E60424485B1757B01106FB1D33067F6F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_C01F491C5B0558E3DA13FB1D33061923" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_C01F491C5B0558E3DA13FB1D33061923" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_MortgageBackedSecuritiesAmortizedCost" xlink:label="loc_agnc_MortgageBackedSecuritiesAmortizedCost_80CEAE12023282311033FB1D3306ABA3" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_30D410AA40E147846C82FB1D3302F77F" xlink:to="loc_agnc_MortgageBackedSecuritiesAmortizedCost_80CEAE12023282311033FB1D3306ABA3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_E5747052C6AE54289ECE53A3F99951B2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_843605C6AED15412BD5B319F8070E141" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_E5747052C6AE54289ECE53A3F99951B2" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_843605C6AED15412BD5B319F8070E141" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_4CA5DD4316BE5A4AB3A2B9938E4BFC5F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_843605C6AED15412BD5B319F8070E141" xlink:to="loc_us-gaap_FinancialInstrumentAxis_4CA5DD4316BE5A4AB3A2B9938E4BFC5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_4CA5DD4316BE5A4AB3A2B9938E4BFC5F" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FixedIncomeSecuritiesMember" xlink:label="loc_us-gaap_FixedIncomeSecuritiesMember_9E73626D137B5636A5CDC2BC97389289" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:to="loc_us-gaap_FixedIncomeSecuritiesMember_9E73626D137B5636A5CDC2BC97389289" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AdjustableRateMember" xlink:label="loc_agnc_AdjustableRateMember_080EB94B7A49517EB17DCE1B7D9E277F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:to="loc_agnc_AdjustableRateMember_080EB94B7A49517EB17DCE1B7D9E277F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollateralizedMortgageObligationsMember" xlink:label="loc_us-gaap_CollateralizedMortgageObligationsMember_3F4D07B873AF54B5A6BBDD7B5C59CB8A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:to="loc_us-gaap_CollateralizedMortgageObligationsMember_3F4D07B873AF54B5A6BBDD7B5C59CB8A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MultifamilyMember" xlink:label="loc_srt_MultifamilyMember_68F46EAF4AD8589783D2B3D515630B43" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:to="loc_srt_MultifamilyMember_68F46EAF4AD8589783D2B3D515630B43" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_709A7371C2185853A42258A11ABBB4C2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_709A7371C2185853A42258A11ABBB4C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_C7D3114947855D299536553D5026B65F" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEBC050917515409A7287DCE97163308" xlink:to="loc_us-gaap_AgencySecuritiesMember_C7D3114947855D299536553D5026B65F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_8EA1BFCF6BC45D8CABF66E696A9F5201" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_843605C6AED15412BD5B319F8070E141" xlink:to="loc_us-gaap_InvestmentTypeAxis_8EA1BFCF6BC45D8CABF66E696A9F5201" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_24D92E6FDACD5AA5B08FE7D5251D4BAE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_8EA1BFCF6BC45D8CABF66E696A9F5201" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_24D92E6FDACD5AA5B08FE7D5251D4BAE" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_24D92E6FDACD5AA5B08FE7D5251D4BAE" xlink:to="loc_us-gaap_AgencySecuritiesMember_C7D3114947855D299536553D5026B65F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_5D7A687CAD725D75B14A06245FA72EAB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_24D92E6FDACD5AA5B08FE7D5251D4BAE" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_5D7A687CAD725D75B14A06245FA72EAB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_D6D826FC4D8D5C93A5A02F329F8A6900" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_24D92E6FDACD5AA5B08FE7D5251D4BAE" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_D6D826FC4D8D5C93A5A02F329F8A6900" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_DBB0265165D857168C85D76DB66FB089" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_24D92E6FDACD5AA5B08FE7D5251D4BAE" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_DBB0265165D857168C85D76DB66FB089" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_C4CDEFC6672B55CBA785D2297D1C6416" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_843605C6AED15412BD5B319F8070E141" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_C4CDEFC6672B55CBA785D2297D1C6416" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" xlink:label="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_AFBEF2B5403E585C8097D965667FEFB2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_C4CDEFC6672B55CBA785D2297D1C6416" xlink:to="loc_agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis_AFBEF2B5403E585C8097D965667FEFB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_2DCA0857857751F9936F69AF882435E8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_C4CDEFC6672B55CBA785D2297D1C6416" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_2DCA0857857751F9936F69AF882435E8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TotalAgencySecurities" xlink:label="loc_agnc_TotalAgencySecurities_08C710EF28B454BD9ACCD8F2C38F399C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsLineItems_C4CDEFC6672B55CBA785D2297D1C6416" xlink:to="loc_agnc_TotalAgencySecurities_08C710EF28B454BD9ACCD8F2C38F399C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_AD8DFC50173E5AF1881CCB97BC7F03AC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_AD8DFC50173E5AF1881CCB97BC7F03AC" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_9CAE4ED8AA975623BC60AF89F4BEA3E8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:to="loc_us-gaap_FinancialInstrumentAxis_9CAE4ED8AA975623BC60AF89F4BEA3E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_C2E29134AF605A7FA3E4A821D67F564B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_9CAE4ED8AA975623BC60AF89F4BEA3E8" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_C2E29134AF605A7FA3E4A821D67F564B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_9A82705F3549583198807ED04013F428" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_C2E29134AF605A7FA3E4A821D67F564B" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_9A82705F3549583198807ED04013F428" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_0D3B732C899450A482B0D4FD62BE4B4A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:to="loc_srt_RangeAxis_0D3B732C899450A482B0D4FD62BE4B4A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_AC0CECF906F45170BDF126457B141804" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_0D3B732C899450A482B0D4FD62BE4B4A" xlink:to="loc_srt_RangeMember_AC0CECF906F45170BDF126457B141804" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_5799FDDE16F155A99250F878F1D1304B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_AC0CECF906F45170BDF126457B141804" xlink:to="loc_srt_MinimumMember_5799FDDE16F155A99250F878F1D1304B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_D6E08123947E55A3AB28109EB722869F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_AC0CECF906F45170BDF126457B141804" xlink:to="loc_srt_MaximumMember_D6E08123947E55A3AB28109EB722869F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_D0BE5C6B654A537DA7A654F2FBB0AF6C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_D0BE5C6B654A537DA7A654F2FBB0AF6C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_3AB108BBE7B0540AAB370D430DBCA756" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_D0BE5C6B654A537DA7A654F2FBB0AF6C" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_3AB108BBE7B0540AAB370D430DBCA756" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:label="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_D3F7100B0255575E9F72F3AF13606657" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3AB108BBE7B0540AAB370D430DBCA756" xlink:to="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_D3F7100B0255575E9F72F3AF13606657" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_7E3723614CE555BC9AC3D6A68308322B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_7E3723614CE555BC9AC3D6A68308322B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_001CD609A4B655ED9F90418E849A3DA8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_7E3723614CE555BC9AC3D6A68308322B" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_001CD609A4B655ED9F90418E849A3DA8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3C5F12CE15A057769018694104AA889C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_001CD609A4B655ED9F90418E849A3DA8" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3C5F12CE15A057769018694104AA889C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_A042BBC20481510CA200D36702B531CB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:to="loc_us-gaap_InvestmentTypeAxis_A042BBC20481510CA200D36702B531CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_491696C4C65F500E8082CA21D9DA393B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_A042BBC20481510CA200D36702B531CB" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_491696C4C65F500E8082CA21D9DA393B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_0ABF6269956456B290EE98A3E86E4077" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_491696C4C65F500E8082CA21D9DA393B" xlink:to="loc_us-gaap_AgencySecuritiesMember_0ABF6269956456B290EE98A3E86E4077" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_C8B95C18C90A520586788FF2F9C93563" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_491696C4C65F500E8082CA21D9DA393B" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_C8B95C18C90A520586788FF2F9C93563" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_491696C4C65F500E8082CA21D9DA393B" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_9A82705F3549583198807ED04013F428" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_CB9116FB77AD51A28238FC4193F4D55B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_491696C4C65F500E8082CA21D9DA393B" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_CB9116FB77AD51A28238FC4193F4D55B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_989379378D7458E68D5B304D719BAC0E" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure" xlink:label="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_05E7D90709D959A0892F030EDA8C48D5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_MortgageBackedSecuritiesAvailableForSaleFairValueDisclosure_05E7D90709D959A0892F030EDA8C48D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_479AB49FCA995864A08D1ADF9F7753AC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_479AB49FCA995864A08D1ADF9F7753AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_B2CF88628270564DA698118F450E2085" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_B2CF88628270564DA698118F450E2085" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_D4A01EE2FFF25E7382ADCD734D421AE4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_D4A01EE2FFF25E7382ADCD734D421AE4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" xlink:label="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_52B733F09FF0509793A0F52B9225AC3C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio_52B733F09FF0509793A0F52B9225AC3C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageCouponRate" xlink:label="loc_agnc_WeightedAverageCouponRate_77700E117DCE56D2BC82F9B60EE76861" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_agnc_WeightedAverageCouponRate_77700E117DCE56D2BC82F9B60EE76861" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_UnderlyingCollateralCoupon" xlink:label="loc_agnc_UnderlyingCollateralCoupon_BF3B4B1A52D552038A263E53357448E6" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_agnc_UnderlyingCollateralCoupon_BF3B4B1A52D552038A263E53357448E6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_EC955816B963560A8D47229610962C7F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities_EC955816B963560A8D47229610962C7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesHeldAsCollateralAtFairValue" xlink:label="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_5C3ADC89257D5D67803CB2E3F35D537C" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_SecuritiesHeldAsCollateralAtFairValue_5C3ADC89257D5D67803CB2E3F35D537C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_1CF5296E2A0458E69C48000BEEBCF79B" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_1CF5296E2A0458E69C48000BEEBCF79B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_70EA62AC6A5C5A3AB82CB9B8B7E623F6" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_OtherLongTermDebt_70EA62AC6A5C5A3AB82CB9B8B7E623F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_CEB5CDD37718584F9011F8D8D757415B" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_CEB5CDD37718584F9011F8D8D757415B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FairValueOfCmoSecuritiesDirectlyHeld" xlink:label="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_D346458566385086B99CF47C01AD64A7" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_agnc_FairValueOfCmoSecuritiesDirectlyHeld_D346458566385086B99CF47C01AD64A7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SecuritizedCmoSecurities" xlink:label="loc_agnc_SecuritizedCmoSecurities_B553307F59C25828A6E89DE1DBBF851E" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_agnc_SecuritizedCmoSecurities_B553307F59C25828A6E89DE1DBBF851E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" xlink:label="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_5AB5636B4A685119AB11FCF88D13CF30" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure_5AB5636B4A685119AB11FCF88D13CF30" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_8159AD884FB458D6A02814EF9BB5B659" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5E02E992A9DE5D60A67D6996EE2070CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_8159AD884FB458D6A02814EF9BB5B659" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2ACD468639E55A77AEA94AD8FCB3925B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_46A1369C91D7555EADEE7334477CB713" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2ACD468639E55A77AEA94AD8FCB3925B" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_46A1369C91D7555EADEE7334477CB713" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRatingAxis" xlink:label="loc_agnc_CreditRatingAxis_EFD1B349011753968080ED0F8DAAEB41" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_46A1369C91D7555EADEE7334477CB713" xlink:to="loc_agnc_CreditRatingAxis_EFD1B349011753968080ED0F8DAAEB41" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRatingDomain" xlink:label="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingAxis_EFD1B349011753968080ED0F8DAAEB41" xlink:to="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_BBBRatingMember" xlink:label="loc_agnc_BBBRatingMember_A691ED36E4385DA2BD23A6A4E76EBB9A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:to="loc_agnc_BBBRatingMember_A691ED36E4385DA2BD23A6A4E76EBB9A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_BBRatingMember" xlink:label="loc_agnc_BBRatingMember_809CAB29379E5F1BADBD4A98ECAD5317" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:to="loc_agnc_BBRatingMember_809CAB29379E5F1BADBD4A98ECAD5317" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AAARatingMember" xlink:label="loc_agnc_AAARatingMember_3587F00BA9FA58C6B3E7BFEF84870257" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:to="loc_agnc_AAARatingMember_3587F00BA9FA58C6B3E7BFEF84870257" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AARatingMember" xlink:label="loc_agnc_AARatingMember_5CD88A4DFBAC5E16ACB69BD4F524F5E2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:to="loc_agnc_AARatingMember_5CD88A4DFBAC5E16ACB69BD4F524F5E2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ARatingMember" xlink:label="loc_agnc_ARatingMember_E81B6BBB15CB52B3A7EAB88B12A0BB0D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:to="loc_agnc_ARatingMember_E81B6BBB15CB52B3A7EAB88B12A0BB0D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_BRatingMember" xlink:label="loc_agnc_BRatingMember_F5E461023B715FC09526BD9B8C10A97C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:to="loc_agnc_BRatingMember_F5E461023B715FC09526BD9B8C10A97C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NotRatedMember" xlink:label="loc_agnc_NotRatedMember_E290B4B48157521985535F4EBCBC0DC3" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_CreditRatingDomain_DFE6E3062B115E16A6BBE910F4B1A25F" xlink:to="loc_agnc_NotRatedMember_E290B4B48157521985535F4EBCBC0DC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_E420A21B5813557883B472272AE51560" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_46A1369C91D7555EADEE7334477CB713" xlink:to="loc_us-gaap_FinancialInstrumentAxis_E420A21B5813557883B472272AE51560" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_58D7D39EB7E454BCBD94BE1A7D7DDD48" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_E420A21B5813557883B472272AE51560" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_58D7D39EB7E454BCBD94BE1A7D7DDD48" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SecuritiesRemeasuredatFairValueMember" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_BCA1ABC369EC59DEAB292376DCE2F1DA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_58D7D39EB7E454BCBD94BE1A7D7DDD48" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_BCA1ABC369EC59DEAB292376DCE2F1DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_9BF278A42CA05EA99E076CB96EBE3115" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_58D7D39EB7E454BCBD94BE1A7D7DDD48" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_9BF278A42CA05EA99E076CB96EBE3115" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember" xlink:label="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_F258F20E8B875B04A7CE18437FB860DE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_58D7D39EB7E454BCBD94BE1A7D7DDD48" xlink:to="loc_agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember_F258F20E8B875B04A7CE18437FB860DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_2C702FD38F98591FA8D0BFF17420C443" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_46A1369C91D7555EADEE7334477CB713" xlink:to="loc_us-gaap_InvestmentTypeAxis_2C702FD38F98591FA8D0BFF17420C443" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_7B4E9EB6B0BA5799BA9416653A91E207" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_2C702FD38F98591FA8D0BFF17420C443" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_7B4E9EB6B0BA5799BA9416653A91E207" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_437D2DD0D8EE56A194704831B30BB69A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_7B4E9EB6B0BA5799BA9416653A91E207" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_437D2DD0D8EE56A194704831B30BB69A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_123860743316542780D2CE2ECC181B72" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_7B4E9EB6B0BA5799BA9416653A91E207" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_123860743316542780D2CE2ECC181B72" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_CB040CE9CFA7516F81E839F0A7DF4A2D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_7B4E9EB6B0BA5799BA9416653A91E207" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_CB040CE9CFA7516F81E839F0A7DF4A2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_E5AD161502AE540BA3C5999449E7F76E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_46A1369C91D7555EADEE7334477CB713" xlink:to="loc_srt_RangeAxis_E5AD161502AE540BA3C5999449E7F76E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_2A85CA632FFE5B76AAB374A15EAA6B3F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_E5AD161502AE540BA3C5999449E7F76E" xlink:to="loc_srt_RangeMember_2A85CA632FFE5B76AAB374A15EAA6B3F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_A2902310B1155252B37DDCA87C903985" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_46A1369C91D7555EADEE7334477CB713" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_A2902310B1155252B37DDCA87C903985" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TradingSecuritiesDebt" xlink:label="loc_us-gaap_TradingSecuritiesDebt_80BE401CDC855291873B50D0E0122255" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_A2902310B1155252B37DDCA87C903985" xlink:to="loc_us-gaap_TradingSecuritiesDebt_80BE401CDC855291873B50D0E0122255" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesTradingAndAvailableForSale" xlink:label="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_E87B9FEFDBC25B5E8E5624B53E59B9F6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_A2902310B1155252B37DDCA87C903985" xlink:to="loc_us-gaap_DebtSecuritiesTradingAndAvailableForSale_E87B9FEFDBC25B5E8E5624B53E59B9F6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C699AA1EC07250A0BB9E071F1DFC9D4B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_3A08119FDE175646BEEAB599A64F5028" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C699AA1EC07250A0BB9E071F1DFC9D4B" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_3A08119FDE175646BEEAB599A64F5028" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_C8968CC049655D98B562C64CD6F28537" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_3A08119FDE175646BEEAB599A64F5028" xlink:to="loc_us-gaap_FinancialInstrumentAxis_C8968CC049655D98B562C64CD6F28537" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5974323B134B5F80885351BFAA02D932" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_C8968CC049655D98B562C64CD6F28537" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5974323B134B5F80885351BFAA02D932" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_LessThanorEqualtoThreeYearsMember" xlink:label="loc_agnc_LessThanorEqualtoThreeYearsMember_21A07D3E9AED55B09322D7982B1BD3FF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5974323B134B5F80885351BFAA02D932" xlink:to="loc_agnc_LessThanorEqualtoThreeYearsMember_21A07D3E9AED55B09322D7982B1BD3FF" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" xlink:label="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_FFB86E5308A853939B785F63D4AFA8AD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5974323B134B5F80885351BFAA02D932" xlink:to="loc_agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember_FFB86E5308A853939B785F63D4AFA8AD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanFiveYearsMember" xlink:label="loc_agnc_GreaterThanFiveYearsMember_A1500C7636205631B5AF51B342CC142E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5974323B134B5F80885351BFAA02D932" xlink:to="loc_agnc_GreaterThanFiveYearsMember_A1500C7636205631B5AF51B342CC142E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GreaterThanTenYearsMember" xlink:label="loc_agnc_GreaterThanTenYearsMember_48E170C25859552EAAC9153466A5C11F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5974323B134B5F80885351BFAA02D932" xlink:to="loc_agnc_GreaterThanTenYearsMember_48E170C25859552EAAC9153466A5C11F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_3A08119FDE175646BEEAB599A64F5028" xlink:to="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_E9B6B8C9670D5A988BD9B0B99A77DC99" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue_E9B6B8C9670D5A988BD9B0B99A77DC99" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_F8137F1435B85FB6ACA827EE45A80B18" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost_F8137F1435B85FB6ACA827EE45A80B18" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_7074C6A341C25E89B540F4C064915452" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:to="loc_us-gaap_AvailableForSaleSecurities_7074C6A341C25E89B540F4C064915452" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_B873520F5C8751549B63332CAC094995" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_B873520F5C8751549B63332CAC094995" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_77A0B9F25C495871A1B03598B497AF8F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate_77A0B9F25C495871A1B03598B497AF8F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" xlink:label="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_97CDC97645765D22971C20166A923BC0" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F01410BE2F295D898A8F83C79ED6112A" xlink:to="loc_agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield_97CDC97645765D22971C20166A923BC0" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2142644795D657E0BD0A51391E9AF1C0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_040D6E6FE5C15FEABBB3655B71241B5E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2142644795D657E0BD0A51391E9AF1C0" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_040D6E6FE5C15FEABBB3655B71241B5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_25C29369A2AA5C9194C526119C5715A7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_040D6E6FE5C15FEABBB3655B71241B5E" xlink:to="loc_us-gaap_FinancialInstrumentAxis_25C29369A2AA5C9194C526119C5715A7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_54B97C3D68A6529CB662DB1C5434ED01" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_25C29369A2AA5C9194C526119C5715A7" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_54B97C3D68A6529CB662DB1C5434ED01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_92CED3E887835CD0A4ECEFC15F8A338E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_54B97C3D68A6529CB662DB1C5434ED01" xlink:to="loc_us-gaap_AgencySecuritiesMember_92CED3E887835CD0A4ECEFC15F8A338E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_7DDBC0E5D1805694AD4D9CD16D4F380A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_040D6E6FE5C15FEABBB3655B71241B5E" xlink:to="loc_us-gaap_StatementLineItems_7DDBC0E5D1805694AD4D9CD16D4F380A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AccumulatedOtherComprehensiveIncomeLossRollForward" xlink:label="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_CE70245701CA5B57B73D256E58CB4CF1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_7DDBC0E5D1805694AD4D9CD16D4F380A" xlink:to="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_CE70245701CA5B57B73D256E58CB4CF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_8477C112C0E75DECA6BB3E8DB989686E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_CE70245701CA5B57B73D256E58CB4CF1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_8477C112C0E75DECA6BB3E8DB989686E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_EDAF6A91E087556F9761C254D075270F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_CE70245701CA5B57B73D256E58CB4CF1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_EDAF6A91E087556F9761C254D075270F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_1810674EBDA3530BAF7E681B3FB5198A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_CE70245701CA5B57B73D256E58CB4CF1" xlink:to="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_1810674EBDA3530BAF7E681B3FB5198A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_49CB24D760725E4982E42774F173067B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_AccumulatedOtherComprehensiveIncomeLossRollForward_CE70245701CA5B57B73D256E58CB4CF1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_49CB24D760725E4982E42774F173067B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_035F172410FF5C8087AB3A58F66E76D4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_A1C763D996FE5142AA30C29C54CB0842" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_035F172410FF5C8087AB3A58F66E76D4" xlink:to="loc_us-gaap_StatementTable_A1C763D996FE5142AA30C29C54CB0842" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2F4F1596DE7859EE9ED5289F6E7A58DD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A1C763D996FE5142AA30C29C54CB0842" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2F4F1596DE7859EE9ED5289F6E7A58DD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_96456901E93651308ABB3D538C9FE082" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2F4F1596DE7859EE9ED5289F6E7A58DD" xlink:to="loc_us-gaap_EquityComponentDomain_96456901E93651308ABB3D538C9FE082" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_E5A3BE5DFC4D59A08F0FA8D839E91F70" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_96456901E93651308ABB3D538C9FE082" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_E5A3BE5DFC4D59A08F0FA8D839E91F70" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A1C763D996FE5142AA30C29C54CB0842" xlink:to="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_524846D7E625585DA456E2CB846755D9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_524846D7E625585DA456E2CB846755D9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_992FB9C1B8BE578EBF618CAE40DDED13" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_992FB9C1B8BE578EBF618CAE40DDED13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_4419324285CD58F8B662BB68AF71E246" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_4419324285CD58F8B662BB68AF71E246" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_2D70C29FEE1354A6A422F6388230535E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_2D70C29FEE1354A6A422F6388230535E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_EF03BF443F295797A78A4AC575981D5E" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_EF03BF443F295797A78A4AC575981D5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2C1E9C68700D5678825FE58625A92A74" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1378531C6F3A531684B1676ED0605336" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2C1E9C68700D5678825FE58625A92A74" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C633B3860F09E1E0C2FBFA4A83D3D7FD" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_90527F994C44985B2BCAFA4A83D3B5F8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C633B3860F09E1E0C2FBFA4A83D3D7FD" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_90527F994C44985B2BCAFA4A83D3B5F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_E5E7D54E1ACD842AF985FA4A83D35B3D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_90527F994C44985B2BCAFA4A83D3B5F8" xlink:to="loc_us-gaap_InvestmentTypeAxis_E5E7D54E1ACD842AF985FA4A83D35B3D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_9AE89F52BA91035D7B1DFA4A83D35457" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_E5E7D54E1ACD842AF985FA4A83D35B3D" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_9AE89F52BA91035D7B1DFA4A83D35457" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CostandProceedsofInvestmentSecuritiesMember" xlink:label="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_68940C681D8DF2071491FA4A83D43E1F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9AE89F52BA91035D7B1DFA4A83D35457" xlink:to="loc_agnc_CostandProceedsofInvestmentSecuritiesMember_68940C681D8DF2071491FA4A83D43E1F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GrossGainLossofInvestmentSecuritiesMember" xlink:label="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_666B82ADCAB42CF40643FA4A83D4302F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9AE89F52BA91035D7B1DFA4A83D35457" xlink:to="loc_agnc_GrossGainLossofInvestmentSecuritiesMember_666B82ADCAB42CF40643FA4A83D4302F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_EBB3218AEBB29D334755FA4A83D421DB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_90527F994C44985B2BCAFA4A83D3B5F8" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_EBB3218AEBB29D334755FA4A83D421DB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_98B3A17A639D1BB13557FA4A83D4B982" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_EBB3218AEBB29D334755FA4A83D421DB" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_98B3A17A639D1BB13557FA4A83D4B982" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestOnlyAndPrincipalOnlyStripMember" xlink:label="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3EEEE04CF8AC823A94D3FA4A83D5717E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_98B3A17A639D1BB13557FA4A83D4B982" xlink:to="loc_agnc_InterestOnlyAndPrincipalOnlyStripMember_3EEEE04CF8AC823A94D3FA4A83D5717E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassAxis" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_FA211E1DDA7AEFFBB521FA4A83D54EE4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_90527F994C44985B2BCAFA4A83D3B5F8" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_FA211E1DDA7AEFFBB521FA4A83D54EE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassDomain" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_12A802FDC4CE4DAA0AEBFA4A83D5DF59" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_FA211E1DDA7AEFFBB521FA4A83D54EE4" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_12A802FDC4CE4DAA0AEBFA4A83D5DF59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_A9C62E767BCC56D996EAFA4A83D65ADD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_12A802FDC4CE4DAA0AEBFA4A83D5DF59" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_A9C62E767BCC56D996EAFA4A83D65ADD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SecuritiesRemeasuredatFairValueMember" xlink:label="loc_agnc_SecuritiesRemeasuredatFairValueMember_2E8A3F4E4ABF948F31B9FA4A83D67155" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_12A802FDC4CE4DAA0AEBFA4A83D5DF59" xlink:to="loc_agnc_SecuritiesRemeasuredatFairValueMember_2E8A3F4E4ABF948F31B9FA4A83D67155" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesAssetsMember" xlink:label="loc_us-gaap_SecuritiesAssetsMember_1C6743C3132A79838F82FA4A83D6B55F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_12A802FDC4CE4DAA0AEBFA4A83D5DF59" xlink:to="loc_us-gaap_SecuritiesAssetsMember_1C6743C3132A79838F82FA4A83D6B55F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_90527F994C44985B2BCAFA4A83D3B5F8" xlink:to="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GainLossOnOtherDebt" xlink:label="loc_agnc_GainLossOnOtherDebt_B2F3B8E69EC97C0AE0A6FA4A83D7BA1A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_agnc_GainLossOnOtherDebt_B2F3B8E69EC97C0AE0A6FA4A83D7BA1A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CostOfSaleOfAvailableForSaleSecuities" xlink:label="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_3AC79AC8B70E322B1270FA4A83D7A3B8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_agnc_CostOfSaleOfAvailableForSaleSecuities_3AC79AC8B70E322B1270FA4A83D7A3B8" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CostofSaleofFairValueOptionSecurities" xlink:label="loc_agnc_CostofSaleofFairValueOptionSecurities_347029FA5C9975691C78FA4A83D7C3E1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_agnc_CostofSaleofFairValueOptionSecurities_347029FA5C9975691C78FA4A83D7C3E1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CostofSaleofInvestmentSecurities" xlink:label="loc_agnc_CostofSaleofInvestmentSecurities_60F31F93DC3F244D9FF2FA4A83D7C4AA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_agnc_CostofSaleofInvestmentSecurities_60F31F93DC3F244D9FF2FA4A83D7C4AA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_B952D6B7A2D60AE8E38DFA4A83D79728" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_B952D6B7A2D60AE8E38DFA4A83D79728" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_94D7E8651103F87A9E0FFA4A83D8098A" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_94D7E8651103F87A9E0FFA4A83D8098A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MarketableSecuritiesRealizedGainLoss" xlink:label="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_7C0A167AE89CC72FE474FA4A83D812E8" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_7C0A167AE89CC72FE474FA4A83D812E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EC5B331BB07D5CBEA0D2FA4A83D8CC2F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_DB64B3BE0C2288C7F08EFA4A83D6F3F5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EC5B331BB07D5CBEA0D2FA4A83D8CC2F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_ADFFF3FDEA475E22BAB1C064CA99EFA2" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SecuritiesbyCreditRatingTableTextBlock" xlink:label="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_D447D862ADDA521E9D734623DE25E14D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_ADFFF3FDEA475E22BAB1C064CA99EFA2" xlink:to="loc_agnc_SecuritiesbyCreditRatingTableTextBlock_D447D862ADDA521E9D734623DE25E14D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesTextBlock" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_4131028DC6AA5F16B0B393B7291A84CC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_ADFFF3FDEA475E22BAB1C064CA99EFA2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_4131028DC6AA5F16B0B393B7291A84CC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ComponentsOfInvestmentSecuritiesTableTextBlock" xlink:label="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_FFE9AD161AD05DD79EE531456E4CEBCA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_ADFFF3FDEA475E22BAB1C064CA99EFA2" xlink:to="loc_agnc_ComponentsOfInvestmentSecuritiesTableTextBlock_FFE9AD161AD05DD79EE531456E4CEBCA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" xlink:label="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_9BCD369DDB9C545C8C72BD6053ED8673" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_ADFFF3FDEA475E22BAB1C064CA99EFA2" xlink:to="loc_agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock_9BCD369DDB9C545C8C72BD6053ED8673" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" xlink:label="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_5303371300185153A3E4E29364FB0921" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_ADFFF3FDEA475E22BAB1C064CA99EFA2" xlink:to="loc_agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock_5303371300185153A3E4E29364FB0921" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock" xlink:label="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_BA069F60525A5302946C8BED74D57813" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_ADFFF3FDEA475E22BAB1C064CA99EFA2" xlink:to="loc_agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock_BA069F60525A5302946C8BED74D57813" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NetIncomeLossPerCommonShareAbstract" xlink:label="loc_agnc_NetIncomeLossPerCommonShareAbstract_E59EE701E1305D61A76F4ECDCEDBBD59" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_B65BC1C26CE953229BFA36225417BCA5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_E59EE701E1305D61A76F4ECDCEDBBD59" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_B65BC1C26CE953229BFA36225417BCA5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_0D447BD7989E5CC590525C79AC555084" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_B65BC1C26CE953229BFA36225417BCA5" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_0D447BD7989E5CC590525C79AC555084" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_E0FAF739D5F75DC7B1BF7A5EEF5F1CEF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_0D447BD7989E5CC590525C79AC555084" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_E0FAF739D5F75DC7B1BF7A5EEF5F1CEF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_5DFE2831D2075C668A408859186D489D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_E0FAF739D5F75DC7B1BF7A5EEF5F1CEF" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_5DFE2831D2075C668A408859186D489D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_3FBD9C3F46DE5A30B61E89C8EB1C4851" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_B65BC1C26CE953229BFA36225417BCA5" xlink:to="loc_us-gaap_StatementClassOfStockAxis_3FBD9C3F46DE5A30B61E89C8EB1C4851" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_4D15DE6D743A571C800BD03680708475" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3FBD9C3F46DE5A30B61E89C8EB1C4851" xlink:to="loc_us-gaap_ClassOfStockDomain_4D15DE6D743A571C800BD03680708475" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDilutedLineItems" xlink:label="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_B65BC1C26CE953229BFA36225417BCA5" xlink:to="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageNumberofSharesOutstanding" xlink:label="loc_agnc_WeightedAverageNumberofSharesOutstanding_FF0B454E5A16585A93A8E7B896D30F3A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_agnc_WeightedAverageNumberofSharesOutstanding_FF0B454E5A16585A93A8E7B896D30F3A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding" xlink:label="loc_agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding_EBA1951A52EC5CE0B4CD0749A4667EE4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding_EBA1951A52EC5CE0B4CD0749A4667EE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_1BAF8D82C3C856308B1D95D0C5FD216B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_1BAF8D82C3C856308B1D95D0C5FD216B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_88083F151AE05E5D8B1D3625FC804FC8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_88083F151AE05E5D8B1D3625FC804FC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_61168EDDACCB57A2960846797EBF1983" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_61168EDDACCB57A2960846797EBF1983" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_0C40CEF26D0751BFBACC4CEF6D1FFDC3" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_0C40CEF26D0751BFBACC4CEF6D1FFDC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_D0BA372C0A5E538BA470A9EFA3CE76B0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_us-gaap_EarningsPerShareBasic_D0BA372C0A5E538BA470A9EFA3CE76B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_B7DCD0AB137F59EE81595AD9F75DF628" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_us-gaap_EarningsPerShareDiluted_B7DCD0AB137F59EE81595AD9F75DF628" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_0E121735EB2C5899A2D0ED5CC3903923" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedLineItems_6F809F8D4FD455799E70208944EB104B" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_0E121735EB2C5899A2D0ED5CC3903923" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NetIncomeLossPerCommonShareAbstract" xlink:label="loc_agnc_NetIncomeLossPerCommonShareAbstract_F45098C2037D57F8827FB485D35B6242" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_50FAA65007D75B3AA4AD431DDB6D759B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_F45098C2037D57F8827FB485D35B6242" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_50FAA65007D75B3AA4AD431DDB6D759B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_D17195EE9F975CB4A0B0AF276CCCEA7B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_NetIncomeLossPerCommonShareAbstract_F45098C2037D57F8827FB485D35B6242" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_D17195EE9F975CB4A0B0AF276CCCEA7B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/Organization" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_431539CA0B3D5C19A236FE338A86231B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_8245D25979D558B09D494558D493460A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_431539CA0B3D5C19A236FE338A86231B" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_8245D25979D558B09D494558D493460A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_93517B7D6F8B5249881DAC4DF03C538B" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RequiredAnnualDistributionOfTaxableNetIncome" xlink:label="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_DD2012466B1953E6A6EF848A7D5B0DC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_93517B7D6F8B5249881DAC4DF03C538B" xlink:to="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_DD2012466B1953E6A6EF848A7D5B0DC7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_IntendedAnnualDistributionofTaxableNetIncome" xlink:label="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_707AE0E940EB5D429966458938CC284C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_93517B7D6F8B5249881DAC4DF03C538B" xlink:to="loc_agnc_IntendedAnnualDistributionofTaxableNetIncome_707AE0E940EB5D429966458938CC284C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssets" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_9F5B33FFFF455717BAECC38CFC4B28D1" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsTextBlock" xlink:label="loc_agnc_PledgedAssetsTextBlock_E38ABB4B383C5AB28C5112AADD8DA02B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_9F5B33FFFF455717BAECC38CFC4B28D1" xlink:to="loc_agnc_PledgedAssetsTextBlock_E38ABB4B383C5AB28C5112AADD8DA02B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_53755B1868B4C3CEF5D1FA4A81F61018" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FC4B52510A8870342357FA4A81F63DDE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_53755B1868B4C3CEF5D1FA4A81F61018" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FC4B52510A8870342357FA4A81F63DDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_00D07857FD00DB73760CFA4A81F7BD0D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FC4B52510A8870342357FA4A81F63DDE" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_00D07857FD00DB73760CFA4A81F7BD0D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_420163F88516E7013048FA4A81F73CB0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_00D07857FD00DB73760CFA4A81F7BD0D" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_420163F88516E7013048FA4A81F73CB0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_7DACBA4E880E06A6CF6BFA4A81F79340" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_420163F88516E7013048FA4A81F73CB0" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_7DACBA4E880E06A6CF6BFA4A81F79340" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_UnderPrimeBrokerAgreementsMember" xlink:label="loc_agnc_UnderPrimeBrokerAgreementsMember_0D23753EA25DF0E3AD74FA4A81F8468A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_420163F88516E7013048FA4A81F73CB0" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_0D23753EA25DF0E3AD74FA4A81F8468A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ExcludingCashReceivedMember" xlink:label="loc_agnc_ExcludingCashReceivedMember_B6ADCA3B441680C0966AFA4A81F8BE94" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_420163F88516E7013048FA4A81F73CB0" xlink:to="loc_agnc_ExcludingCashReceivedMember_B6ADCA3B441680C0966AFA4A81F8BE94" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassAxis" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_B1A97C7A61518C98846DFA5886E449AD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FC4B52510A8870342357FA4A81F63DDE" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_B1A97C7A61518C98846DFA5886E449AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassDomain" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_B1A97C7A61518C98846DFA5886E449AD" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_7DACBA4E880E06A6CF6BFA4A81F79340" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_4777189F5F43E7DE0B9EFA4A81FE37FF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_4777189F5F43E7DE0B9EFA4A81FE37FF" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_0D23753EA25DF0E3AD74FA4A81F8468A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_IncludesSoldButNotYetSettledSecuritiesMember" xlink:label="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_4F4D847712DCFF42FF7EFA4A81FE330D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_agnc_IncludesSoldButNotYetSettledSecuritiesMember_4F4D847712DCFF42FF7EFA4A81FE330D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_B24483A1B8B1777D9991FA4A81FEEB1F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_B24483A1B8B1777D9991FA4A81FEEB1F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NonAgencyMember" xlink:label="loc_agnc_NonAgencyMember_5D35C12F6E7DA15E4902FA4A81FF4069" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_agnc_NonAgencyMember_5D35C12F6E7DA15E4902FA4A81FF4069" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AAANonAgencyMortgageBackedSecuritiesMember" xlink:label="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_F25F6317B5DA15F9203EFA4A81FF007E" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_agnc_AAANonAgencyMortgageBackedSecuritiesMember_F25F6317B5DA15F9203EFA4A81FF007E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_D8E35F08075777F3839AFA4A81FFBBAB" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_D8E35F08075777F3839AFA4A81FFBBAB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeMember" xlink:label="loc_us-gaap_DerivativeMember_AD1078A2F9A70BB750F7FA4A81FF207D" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_83FC7FCB4B68990476DCFA58E307563F" xlink:to="loc_us-gaap_DerivativeMember_AD1078A2F9A70BB750F7FA4A81FF207D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_BAFEE0BD7DD53BAC3752FA4A81FFB676" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FC4B52510A8870342357FA4A81F63DDE" xlink:to="loc_us-gaap_InvestmentTypeAxis_BAFEE0BD7DD53BAC3752FA4A81FFB676" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_8D7A3A1A00238806615BFA4A820014D7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_BAFEE0BD7DD53BAC3752FA4A81FFB676" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_8D7A3A1A00238806615BFA4A820014D7" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_8D7A3A1A00238806615BFA4A820014D7" xlink:to="loc_agnc_UnderPrimeBrokerAgreementsMember_0D23753EA25DF0E3AD74FA4A81F8468A" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_8D7A3A1A00238806615BFA4A820014D7" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_7DACBA4E880E06A6CF6BFA4A81F79340" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_8D7A3A1A00238806615BFA4A820014D7" xlink:to="loc_us-gaap_DerivativeMember_AD1078A2F9A70BB750F7FA4A81FF207D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FC4B52510A8870342357FA4A81F63DDE" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_94CEFBC2F8EC40843E1BFA4A8201D7AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:to="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_94CEFBC2F8EC40843E1BFA4A8201D7AB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_E3F1A2FB51FA24C5948FFA4A82011985" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:to="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_E3F1A2FB51FA24C5948FFA4A82011985" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_08F31B6EC11A603836FAFA4A82017DA3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_08F31B6EC11A603836FAFA4A82017DA3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" xlink:label="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8EE091E1B695BE67B04DFA4A820172F2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:to="loc_agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest_8EE091E1B695BE67B04DFA4A820172F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_668459A817554588F70FFA4A82028504" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_668459A817554588F70FFA4A82028504" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest" xlink:label="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_9422FF602FEB80944220FA4A8202CE35" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:to="loc_agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest_9422FF602FEB80944220FA4A8202CE35" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" xlink:label="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_D3BC30B85CF9FA4D1336FA4A82020689" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_B18B358068E1E501E7C0FA4A820004C8" xlink:to="loc_agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest_D3BC30B85CF9FA4D1336FA4A82020689" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_9A5049D5CCF8F5DB68A3FB160E82F3DB" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D73BDBC1CF3482A051AAFB160E8535E5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_9A5049D5CCF8F5DB68A3FB160E82F3DB" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D73BDBC1CF3482A051AAFB160E8535E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_52FC9FA79C887CE7C297FB160E86AF56" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D73BDBC1CF3482A051AAFB160E8535E5" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_52FC9FA79C887CE7C297FB160E86AF56" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_40E651D9694D3E970F35FB160E8611D8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_52FC9FA79C887CE7C297FB160E86AF56" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_40E651D9694D3E970F35FB160E8611D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeMember" xlink:label="loc_us-gaap_DerivativeMember_90351A725FF6DA35F9E9FB160E87B75C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_40E651D9694D3E970F35FB160E8611D8" xlink:to="loc_us-gaap_DerivativeMember_90351A725FF6DA35F9E9FB160E87B75C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_6DA2903AD97BD010845CFB160E87BF90" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D73BDBC1CF3482A051AAFB160E8535E5" xlink:to="loc_us-gaap_InvestmentTypeAxis_6DA2903AD97BD010845CFB160E87BF90" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_49696EA275C8122DAB34FB160E8789CE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_6DA2903AD97BD010845CFB160E87BF90" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_49696EA275C8122DAB34FB160E8789CE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReverseRepurchaseAgreementsMember" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_CB380C391FA3D456A011FB160E88BE68" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_49696EA275C8122DAB34FB160E8789CE" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_CB380C391FA3D456A011FB160E88BE68" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_49696EA275C8122DAB34FB160E8789CE" xlink:to="loc_us-gaap_DerivativeMember_90351A725FF6DA35F9E9FB160E87B75C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassAxis" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_6183AF5D651468017E21FB160E8808A9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D73BDBC1CF3482A051AAFB160E8535E5" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_6183AF5D651468017E21FB160E8808A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassDomain" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_B0F9B4E732F64E755056FB160E895E00" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_6183AF5D651468017E21FB160E8808A9" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_B0F9B4E732F64E755056FB160E895E00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_D64B1AB70E753D7E36B2FB160E893FD4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_B0F9B4E732F64E755056FB160E895E00" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByUSGovernmentSponsoredEnterprisesMember_D64B1AB70E753D7E36B2FB160E893FD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_5CF554AD099507A722D5FB160E89EC30" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_B0F9B4E732F64E755056FB160E895E00" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_5CF554AD099507A722D5FB160E89EC30" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_B0F9B4E732F64E755056FB160E895E00" xlink:to="loc_us-gaap_DerivativeMember_90351A725FF6DA35F9E9FB160E87B75C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_55FCDA4A1D06975A7852FB160E8911EA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_B0F9B4E732F64E755056FB160E895E00" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_55FCDA4A1D06975A7852FB160E8911EA" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_B0F9B4E732F64E755056FB160E895E00" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_CB380C391FA3D456A011FB160E88BE68" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_C305E4B4133E59B92772FB160E8A3C04" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D73BDBC1CF3482A051AAFB160E8535E5" xlink:to="loc_us-gaap_FinancialInstrumentAxis_C305E4B4133E59B92772FB160E8A3C04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9436680C563920A55E6EFB160E8A635F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_C305E4B4133E59B92772FB160E8A3C04" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9436680C563920A55E6EFB160E8A635F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AssetsPledgedtoUsMember" xlink:label="loc_agnc_AssetsPledgedtoUsMember_89EFE13F81196EA1B3DFFB160E8A7BB6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9436680C563920A55E6EFB160E8A635F" xlink:to="loc_agnc_AssetsPledgedtoUsMember_89EFE13F81196EA1B3DFFB160E8A7BB6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_03BD02D400EB727F0D8BFB160E8BD84E" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_D73BDBC1CF3482A051AAFB160E8535E5" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_03BD02D400EB727F0D8BFB160E8BD84E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedMortgageRelatedSecuritiesAvailableForSaleOrHeldForInvestment" xlink:label="loc_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedMortgageRelatedSecuritiesAvailableForSaleOrHeldForInvestment_9798D097B38F0FD5386FFB160E8B1CCC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_03BD02D400EB727F0D8BFB160E8BD84E" xlink:to="loc_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedMortgageRelatedSecuritiesAvailableForSaleOrHeldForInvestment_9798D097B38F0FD5386FFB160E8B1CCC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_A9D1CFD1933EF1DFFE7AFB160E8B5DC3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_03BD02D400EB727F0D8BFB160E8BD84E" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_A9D1CFD1933EF1DFFE7AFB160E8B5DC3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_4A5DB1CB2AC7C601E7C7FB160E8B20DB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_03BD02D400EB727F0D8BFB160E8BD84E" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_4A5DB1CB2AC7C601E7C7FB160E8B20DB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_916418CB47EBD02D7F71FB160E8B6D94" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_03BD02D400EB727F0D8BFB160E8BD84E" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_916418CB47EBD02D7F71FB160E8B6D94" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RestrictedCashandSecuritiesPledged" xlink:label="loc_agnc_RestrictedCashandSecuritiesPledged_D935F113FD0F2D944E9EFB160E8B8A67" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_03BD02D400EB727F0D8BFB160E8BD84E" xlink:to="loc_agnc_RestrictedCashandSecuritiesPledged_D935F113FD0F2D944E9EFB160E8B8A67" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_4B08E76FD10A7A1BC3FFF6EBFE67F78F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="loc_us-gaap_FederalHomeLoanBankStock_1867D82512B405B06A8DF6EBFE68A9D2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_4B08E76FD10A7A1BC3FFF6EBFE67F78F" xlink:to="loc_us-gaap_FederalHomeLoanBankStock_1867D82512B405B06A8DF6EBFE68A9D2" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_DFF6E93F8B823E16714FF6EBFE68190B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_4B08E76FD10A7A1BC3FFF6EBFE67F78F" xlink:to="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_DFF6E93F8B823E16714FF6EBFE68190B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CreditDerivativeMaximumExposureUndiscounted" xlink:label="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_7A2420CE35ABDB4CFD7FF6EBFE688834" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_4B08E76FD10A7A1BC3FFF6EBFE67F78F" xlink:to="loc_us-gaap_CreditDerivativeMaximumExposureUndiscounted_7A2420CE35ABDB4CFD7FF6EBFE688834" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_0E3213C860C454DF922C058A222896CD" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FBF06D66443A5E79B9BE80B1EF5F2966" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_0E3213C860C454DF922C058A222896CD" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FBF06D66443A5E79B9BE80B1EF5F2966" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_8D781A8057B4557EAA8958A8BA65161B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FBF06D66443A5E79B9BE80B1EF5F2966" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_8D781A8057B4557EAA8958A8BA65161B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_E6853E0F268D5D669A7047FF7B64239E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8D781A8057B4557EAA8958A8BA65161B" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_E6853E0F268D5D669A7047FF7B64239E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReverseRepurchaseAgreementsMember" xlink:label="loc_agnc_ReverseRepurchaseAgreementsMember_245B2854C66D5A6DB5E1A1593DF809D0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_E6853E0F268D5D669A7047FF7B64239E" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_245B2854C66D5A6DB5E1A1593DF809D0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_730746D8240D57C38D802BE650EE47A6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_E6853E0F268D5D669A7047FF7B64239E" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_730746D8240D57C38D802BE650EE47A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_CD51D28C65135D05A864C82E9FD3C2F8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FBF06D66443A5E79B9BE80B1EF5F2966" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_CD51D28C65135D05A864C82E9FD3C2F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_C2669D5A68855B82B4FF09832AF0A5B8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_CD51D28C65135D05A864C82E9FD3C2F8" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_C2669D5A68855B82B4FF09832AF0A5B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsMember" xlink:label="loc_us-gaap_AssetsMember_7567A48B360156949AE2E90BE75CCE57" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_C2669D5A68855B82B4FF09832AF0A5B8" xlink:to="loc_us-gaap_AssetsMember_7567A48B360156949AE2E90BE75CCE57" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilityMember" xlink:label="loc_us-gaap_LiabilityMember_F18BC1BD11BA5E13931E0021E894BD9A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_C2669D5A68855B82B4FF09832AF0A5B8" xlink:to="loc_us-gaap_LiabilityMember_F18BC1BD11BA5E13931E0021E894BD9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_3A391585C99F562B9F8943E5680FA21B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FBF06D66443A5E79B9BE80B1EF5F2966" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_3A391585C99F562B9F8943E5680FA21B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_BF6EA047BBDD521BA046DF08CFD72C35" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_3A391585C99F562B9F8943E5680FA21B" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_BF6EA047BBDD521BA046DF08CFD72C35" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_556227D54D9C5F889430BD9F66BEA195" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_BF6EA047BBDD521BA046DF08CFD72C35" xlink:to="loc_us-gaap_InterestRateSwapMember_556227D54D9C5F889430BD9F66BEA195" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_BF6EA047BBDD521BA046DF08CFD72C35" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_730746D8240D57C38D802BE650EE47A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SwaptionMember" xlink:label="loc_us-gaap_SwaptionMember_CBE32CCC58D85D0B86163407441A8F1B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_BF6EA047BBDD521BA046DF08CFD72C35" xlink:to="loc_us-gaap_SwaptionMember_CBE32CCC58D85D0B86163407441A8F1B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_C49975BC4D595CA3AF3B3CF8F963D98F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_BF6EA047BBDD521BA046DF08CFD72C35" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_C49975BC4D595CA3AF3B3CF8F963D98F" xlink:type="arc" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_BF6EA047BBDD521BA046DF08CFD72C35" xlink:to="loc_agnc_ReverseRepurchaseAgreementsMember_245B2854C66D5A6DB5E1A1593DF809D0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_FBF06D66443A5E79B9BE80B1EF5F2966" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GrossAmountOfRecognizedAssetsLiabilities" xlink:label="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_1AFC04B758A259E7B26B3B7DE0907CFA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:to="loc_agnc_GrossAmountOfRecognizedAssetsLiabilities_1AFC04B758A259E7B26B3B7DE0907CFA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" xlink:label="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_C1E7C6F374415481AF8DA2BCCAA077FB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:to="loc_agnc_GrossAmountOffsetintheConsolidatedBalanceSheets_C1E7C6F374415481AF8DA2BCCAA077FB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:label="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_D9E89E342BBC5681BDCDACD208CAE50F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:to="loc_agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_D9E89E342BBC5681BDCDACD208CAE50F" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" xlink:label="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_86616BE854A754BA9E5BAB9967165711" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:to="loc_agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet_86616BE854A754BA9E5BAB9967165711" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" xlink:label="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_530DB23897CE542B9732799E8F3DEA52" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:to="loc_agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet_530DB23897CE542B9732799E8F3DEA52" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" xlink:label="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_6A99A4C5BAC5565FAACF2E8BAD77F25C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_2B87430CF7CA55099C4EA03C5CBBC1CD" xlink:to="loc_agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet_6A99A4C5BAC5565FAACF2E8BAD77F25C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_8DFB085D19BF3576EDDDE5372CA55149" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_5A128AAED54E464BC4F6E5372CA5CD21" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_8DFB085D19BF3576EDDDE5372CA55149" xlink:to="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_5A128AAED54E464BC4F6E5372CA5CD21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_ECBC73E8415DCDF9A61EE5372CA5F7EA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_5A128AAED54E464BC4F6E5372CA5CD21" xlink:to="loc_srt_CounterpartyNameAxis_ECBC73E8415DCDF9A61EE5372CA5F7EA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_72BAC6759018DC0E2F70E5372CA5D030" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_ECBC73E8415DCDF9A61EE5372CA5F7EA" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_72BAC6759018DC0E2F70E5372CA5D030" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FICCMember" xlink:label="loc_agnc_FICCMember_5D78805B9E0E4038970CE5372CA636D4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_72BAC6759018DC0E2F70E5372CA5D030" xlink:to="loc_agnc_FICCMember_5D78805B9E0E4038970CE5372CA636D4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_J.P.MorganSecuritiesLLCMember" xlink:label="loc_agnc_J.P.MorganSecuritiesLLCMember_614A14301E21D7BAE454E5372CA68EB7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_72BAC6759018DC0E2F70E5372CA5D030" xlink:to="loc_agnc_J.P.MorganSecuritiesLLCMember_614A14301E21D7BAE454E5372CA68EB7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" xlink:label="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_61D210953E1945252C3BE5372CA6CAC8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable_5A128AAED54E464BC4F6E5372CA5CD21" xlink:to="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_61D210953E1945252C3BE5372CA6CAC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_B6657A3BDE0CCEEB86DBE5372CA79C9C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_61D210953E1945252C3BE5372CA6CAC8" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_B6657A3BDE0CCEEB86DBE5372CA79C9C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RiskOfRepurchaseAgreementToStockholdersEquity" xlink:label="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_4BB4AE47AD1499726179E5372CA726A5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_61D210953E1945252C3BE5372CA6CAC8" xlink:to="loc_agnc_RiskOfRepurchaseAgreementToStockholdersEquity_4BB4AE47AD1499726179E5372CA726A5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_2ADE2F01785D6F1A3681E5372CA7C269" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_61D210953E1945252C3BE5372CA6CAC8" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_2ADE2F01785D6F1A3681E5372CA7C269" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CounterpartyExposureNet" xlink:label="loc_agnc_CounterpartyExposureNet_EB25CACA9077DCE88EEBE5372CA79F16" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_61D210953E1945252C3BE5372CA6CAC8" xlink:to="loc_agnc_CounterpartyExposureNet_EB25CACA9077DCE88EEBE5372CA79F16" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_8B1A8B85BDB964E78F1DE5372CA7C021" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems_61D210953E1945252C3BE5372CA6CAC8" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity_8B1A8B85BDB964E78F1DE5372CA7C021" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_B81B311AB0F68DCAAAE8FA4A81D3DF03" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesTable" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesTable_26D1B1B437F3FAA13FB8FA4A81D3AB31" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_B81B311AB0F68DCAAAE8FA4A81D3DF03" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesTable_26D1B1B437F3FAA13FB8FA4A81D3AB31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassAxis" xlink:label="loc_us-gaap_UnderlyingAssetClassAxis_23C53FA0BAB2265B2477FA5ACE6B0A5A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_26D1B1B437F3FAA13FB8FA4A81D3AB31" xlink:to="loc_us-gaap_UnderlyingAssetClassAxis_23C53FA0BAB2265B2477FA5ACE6B0A5A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnderlyingAssetClassDomain" xlink:label="loc_us-gaap_UnderlyingAssetClassDomain_65A3EF94CC8E09A418F3FA5ACE6F442D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassAxis_23C53FA0BAB2265B2477FA5ACE6B0A5A" xlink:to="loc_us-gaap_UnderlyingAssetClassDomain_65A3EF94CC8E09A418F3FA5ACE6F442D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CreditRiskTransferSecuritiesMember" xlink:label="loc_agnc_CreditRiskTransferSecuritiesMember_CB0011AA5D0B7A7F8E17FA5B2E25589B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_65A3EF94CC8E09A418F3FA5ACE6F442D" xlink:to="loc_agnc_CreditRiskTransferSecuritiesMember_CB0011AA5D0B7A7F8E17FA5B2E25589B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_CD2509EC1B6FF517F695FA4A81D62C2E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_65A3EF94CC8E09A418F3FA5ACE6F442D" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_CD2509EC1B6FF517F695FA4A81D62C2E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_NonAgencyMember" xlink:label="loc_agnc_NonAgencyMember_7CF228B2B5BC9C7C7D94FA5B2E25F2CF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnderlyingAssetClassDomain_65A3EF94CC8E09A418F3FA5ACE6F442D" xlink:to="loc_agnc_NonAgencyMember_7CF228B2B5BC9C7C7D94FA5B2E25F2CF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_4F06BDBDC2E0237D4532FA4A81D485F2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_26D1B1B437F3FAA13FB8FA4A81D3AB31" xlink:to="loc_us-gaap_InvestmentTypeAxis_4F06BDBDC2E0237D4532FA4A81D485F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_9F9AFA633B4371CDBF26FA4A81D51733" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_4F06BDBDC2E0237D4532FA4A81D485F2" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_9F9AFA633B4371CDBF26FA4A81D51733" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_4CD10ADFF760DFFFD27DFA4A81D5FD5B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9F9AFA633B4371CDBF26FA4A81D51733" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_4CD10ADFF760DFFFD27DFA4A81D5FD5B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeMember" xlink:label="loc_us-gaap_DerivativeMember_2E0F813368790F614C60FA4A81D583F8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9F9AFA633B4371CDBF26FA4A81D51733" xlink:to="loc_us-gaap_DerivativeMember_2E0F813368790F614C60FA4A81D583F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_6EEFE8DA94F5F57DFE17FA4A81D55F48" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9F9AFA633B4371CDBF26FA4A81D51733" xlink:to="loc_us-gaap_AgencySecuritiesMember_6EEFE8DA94F5F57DFE17FA4A81D55F48" xlink:type="arc" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_9F9AFA633B4371CDBF26FA4A81D51733" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_CD2509EC1B6FF517F695FA4A81D62C2E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_F0768271FAC8FC52E44EFA4A81D639C6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_26D1B1B437F3FAA13FB8FA4A81D3AB31" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_F0768271FAC8FC52E44EFA4A81D639C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D3CF56E357157CE9148AFA4A81D62048" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_F0768271FAC8FC52E44EFA4A81D639C6" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D3CF56E357157CE9148AFA4A81D62048" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_DF58228F5BA83EFCD60FFA4A81D64DF1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D3CF56E357157CE9148AFA4A81D62048" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_DF58228F5BA83EFCD60FFA4A81D64DF1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Maturity31To59DaysMember" xlink:label="loc_agnc_Maturity31To59DaysMember_5A7E8A55108C5CF50DA7FA4A81D77B21" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D3CF56E357157CE9148AFA4A81D62048" xlink:to="loc_agnc_Maturity31To59DaysMember_5A7E8A55108C5CF50DA7FA4A81D77B21" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_Maturity60To90DaysMember" xlink:label="loc_agnc_Maturity60To90DaysMember_73538BE060213FF860D0FA4A81DC50DB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D3CF56E357157CE9148AFA4A81D62048" xlink:to="loc_agnc_Maturity60To90DaysMember_73538BE060213FF860D0FA4A81DC50DB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityOver90DaysMember" xlink:label="loc_us-gaap_MaturityOver90DaysMember_8943B0DE01ABF1DAF95DFA4A81DCCA54" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D3CF56E357157CE9148AFA4A81D62048" xlink:to="loc_us-gaap_MaturityOver90DaysMember_8943B0DE01ABF1DAF95DFA4A81DCCA54" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_76BCFAE0039B84FBEF35FA4A81DCA78A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D3CF56E357157CE9148AFA4A81D62048" xlink:to="loc_agnc_A2Daysto1MonthMember_76BCFAE0039B84FBEF35FA4A81DCA78A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OffsettingAssetsAndLiabilitiesLineItems" xlink:label="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_C066DA6C76136F4229A1FA4A81DC5FF7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesTable_26D1B1B437F3FAA13FB8FA4A81D3AB31" xlink:to="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_C066DA6C76136F4229A1FA4A81DC5FF7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" xlink:label="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_C6AEBA5744310448F557FA4A81DD8526" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_C066DA6C76136F4229A1FA4A81DC5FF7" xlink:to="loc_agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements_C6AEBA5744310448F557FA4A81DD8526" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue" xlink:label="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_8B138B63D9BB22FA96C2FA4A81DD45A4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_C066DA6C76136F4229A1FA4A81DC5FF7" xlink:to="loc_us-gaap_SecurityOwnedAndPledgedAsCollateralFairValue_8B138B63D9BB22FA96C2FA4A81DD45A4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_308706D9DEC6778BC3F7FA4A81DD4777" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_C066DA6C76136F4229A1FA4A81DC5FF7" xlink:to="loc_agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost_308706D9DEC6778BC3F7FA4A81DD4777" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" xlink:label="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_1680BC9BD103D3183C6CFA4A81DD5BF2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_C066DA6C76136F4229A1FA4A81DC5FF7" xlink:to="loc_agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest_1680BC9BD103D3183C6CFA4A81DD5BF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed" xlink:label="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_47CB735E3A448346C63CFA4A81DD5AB8" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_OffsettingAssetsAndLiabilitiesLineItems_C066DA6C76136F4229A1FA4A81DC5FF7" xlink:to="loc_us-gaap_CollateralSecuritiesRepledgedDeliveredOrUsed_47CB735E3A448346C63CFA4A81DD5AB8" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PledgedAssetsAbstract" xlink:label="loc_agnc_PledgedAssetsAbstract_89223D268D98595C87C20E2600D31359" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock" xlink:label="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_7B9C4D36503856D3854C23ADA7677D01" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_89223D268D98595C87C20E2600D31359" xlink:to="loc_agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock_7B9C4D36503856D3854C23ADA7677D01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock" xlink:label="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_8F348A5BA5615E28A997E3DC804E49AA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_89223D268D98595C87C20E2600D31359" xlink:to="loc_us-gaap_ScheduleOfFinancialInstrumentsOwnedAndPledgedAsCollateralTextBlock_8F348A5BA5615E28A997E3DC804E49AA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" xlink:label="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_4DC38C0C69A65CE1842887B853B62833" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_89223D268D98595C87C20E2600D31359" xlink:to="loc_agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock_4DC38C0C69A65CE1842887B853B62833" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OffsettingAssetsTableTextBlock" xlink:label="loc_us-gaap_OffsettingAssetsTableTextBlock_8EC9A39BD7C354A68B3AC0DCF8779500" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_89223D268D98595C87C20E2600D31359" xlink:to="loc_us-gaap_OffsettingAssetsTableTextBlock_8EC9A39BD7C354A68B3AC0DCF8779500" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OffsettingLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_4E88D5DC4AEF59DD9ABC2FFAB65AF665" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_PledgedAssetsAbstract_89223D268D98595C87C20E2600D31359" xlink:to="loc_us-gaap_OffsettingLiabilitiesTableTextBlock_4E88D5DC4AEF59DD9ABC2FFAB65AF665" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_0C27A47A349A5B45BE9C1FFDDFB94E78" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_0C27A47A349A5B45BE9C1FFDDFB94E78" xlink:to="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_42D8E851F1305F04B0E8880811109452" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_42D8E851F1305F04B0E8880811109452" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_42D8E851F1305F04B0E8880811109452" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_8B63FDD09E685C4F8DFB217241D9B65E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_993955857D3058B6832EEAB8B6E18F00" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_8B63FDD09E685C4F8DFB217241D9B65E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_6A0772183F9C567890E4E84F8995F44D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:to="loc_srt_CounterpartyNameAxis_6A0772183F9C567890E4E84F8995F44D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4F15493D4FAF52B2A4D2C51D81F23A42" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_6A0772183F9C567890E4E84F8995F44D" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4F15493D4FAF52B2A4D2C51D81F23A42" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FICCMember" xlink:label="loc_agnc_FICCMember_7B9A38148B955DCFB9FE53BF0FDFD154" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4F15493D4FAF52B2A4D2C51D81F23A42" xlink:to="loc_agnc_FICCMember_7B9A38148B955DCFB9FE53BF0FDFD154" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_576A713B950A57B79F71AE33CBFEC319" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:to="loc_us-gaap_FinancialInstrumentAxis_576A713B950A57B79F71AE33CBFEC319" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CB4E76611E76517188E835EB5098AB67" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_576A713B950A57B79F71AE33CBFEC319" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CB4E76611E76517188E835EB5098AB67" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_56BD3CE0F4FB59FF9602BD924F9641B7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_CB4E76611E76517188E835EB5098AB67" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_56BD3CE0F4FB59FF9602BD924F9641B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:to="loc_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_18D7C87096DB54C99E0D18B7242F5B9A" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_38145C99330751E6BD518B43814014B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_38145C99330751E6BD518B43814014B4" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1DB08AA4B8B4532F8ED0FF97758EC37A" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_56BD3CE0F4FB59FF9602BD924F9641B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_E2DB43C5B0595B8AAEA86EE754093AF0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_E2DB43C5B0595B8AAEA86EE754093AF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_E2DB43C5B0595B8AAEA86EE754093AF0" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_123E5107195956F5A0707D11821ADECD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_us-gaap_MaturityOvernightMember_123E5107195956F5A0707D11821ADECD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_851E5F1443705216BE31BD5BDC4E28DC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_851E5F1443705216BE31BD5BDC4E28DC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_ThirtyOneToNinetyMember_8EBA8F838A3853F2B6C84AF0DA9AE19A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A4to6MonthsMember_539AEC070A1B5E0E964B056968EE6422" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A7to9monthsMember_82A746B4C4D6597BB8C67AB194C21A76" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A10to12MonthsMember_38FDD27A4D63577FA11CE85185F23BA1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A13to24MonthsMember_9F9E37BAD6585BEDA0AB6C2761DE0702" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A25to36monthsMember_F869F80142F45200932183C0BAB73759" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A37to48monthsMember_2DC349C8CFF05D4598D1996C788514A6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A49to60MonthsMember_05016556A7855229AE2DB74F0595F71B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A2Daysto1MonthMember" xlink:label="loc_agnc_A2Daysto1MonthMember_9A54B9DAAAC25FCC983C927C8E4AB3F5" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_6B61CF12271A57E69E8F79513A815188" xlink:to="loc_agnc_A2Daysto1MonthMember_9A54B9DAAAC25FCC983C927C8E4AB3F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_24042E31FACF5C589EA85500DE9D32ED" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_8B8A33D004F55DAD90251EF65AC55EC7" xlink:to="loc_us-gaap_StatementLineItems_24042E31FACF5C589EA85500DE9D32ED" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_0FEBE8DBD7FC5D78B6370FC2EA44E297" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_24042E31FACF5C589EA85500DE9D32ED" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_0FEBE8DBD7FC5D78B6370FC2EA44E297" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_FBA340D558F254EC9DF5D4CB9A12F4B5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_24042E31FACF5C589EA85500DE9D32ED" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_FBA340D558F254EC9DF5D4CB9A12F4B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_74F99A29F8595A5FA5B5EF5D29C2EFEE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_24042E31FACF5C589EA85500DE9D32ED" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_74F99A29F8595A5FA5B5EF5D29C2EFEE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" xlink:label="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_1B9BFD4599E75821AC4A53616969545B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_24042E31FACF5C589EA85500DE9D32ED" xlink:to="loc_agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity_1B9BFD4599E75821AC4A53616969545B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_9C3878976AD857369D05CA01D0D76545" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_24042E31FACF5C589EA85500DE9D32ED" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_9C3878976AD857369D05CA01D0D76545" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_4F4C6C5D600250EEB1342C06C78F24CC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock" xlink:label="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_BB47CA889CAC592EA91097168C8FEC8C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_4F4C6C5D600250EEB1342C06C78F24CC" xlink:to="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_BB47CA889CAC592EA91097168C8FEC8C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_CAFFE2D32B4C5B7D844F7A1F77185AE4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShortTermDebtTable" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract_CAFFE2D32B4C5B7D844F7A1F77185AE4" xlink:to="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_D55E4DE4EBCC5508820E2684A2E385B3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:to="loc_srt_RangeAxis_D55E4DE4EBCC5508820E2684A2E385B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_F9D16052689155C9AAF55FB659478854" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_D55E4DE4EBCC5508820E2684A2E385B3" xlink:to="loc_srt_RangeMember_F9D16052689155C9AAF55FB659478854" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_3806906D760E508AA6F1AC0500F7CEAF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_3806906D760E508AA6F1AC0500F7CEAF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_A26F6B935C2F5489B29E4F35A2F34B7E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_3806906D760E508AA6F1AC0500F7CEAF" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_A26F6B935C2F5489B29E4F35A2F34B7E" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_04056891978655218EC8118946149F64" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_A26F6B935C2F5489B29E4F35A2F34B7E" xlink:to="loc_agnc_A37to48monthsMember_04056891978655218EC8118946149F64" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_3EEBBBB783DD5626AF9901C8AA2569C6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:to="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_3EEBBBB783DD5626AF9901C8AA2569C6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" xlink:label="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_3284A6F1A1B7598EBC56ED11A9798828" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis_3EEBBBB783DD5626AF9901C8AA2569C6" xlink:to="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_3284A6F1A1B7598EBC56ED11A9798828" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_303629BCC4DE58C2AB450C127D436B10" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_3284A6F1A1B7598EBC56ED11A9798828" xlink:to="loc_agnc_A49to60MonthsMember_303629BCC4DE58C2AB450C127D436B10" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_3284A6F1A1B7598EBC56ED11A9798828" xlink:to="loc_agnc_A37to48monthsMember_04056891978655218EC8118946149F64" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_70D70D1D349659CE81754643820C9F09" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_3284A6F1A1B7598EBC56ED11A9798828" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_70D70D1D349659CE81754643820C9F09" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_45967400ABF55381AC59F79EBE07B6B7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_3284A6F1A1B7598EBC56ED11A9798828" xlink:to="loc_agnc_ThirtyOneToNinetyMember_45967400ABF55381AC59F79EBE07B6B7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_FFCF424B64F1510B999FEA4A01490082" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain_3284A6F1A1B7598EBC56ED11A9798828" xlink:to="loc_agnc_A4to6MonthsMember_FFCF424B64F1510B999FEA4A01490082" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_91CA69943E885523B14339F9ED973A1D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_91CA69943E885523B14339F9ED973A1D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_49B232C022D45D469F2392D31AC6F0B9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_91CA69943E885523B14339F9ED973A1D" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_49B232C022D45D469F2392D31AC6F0B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_C186DADA78E85E6AB8C0D11976352E6F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:to="loc_us-gaap_DebtInstrumentAxis_C186DADA78E85E6AB8C0D11976352E6F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_8E1833E5CCFC5E84AC67D3AF19522D75" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_C186DADA78E85E6AB8C0D11976352E6F" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_8E1833E5CCFC5E84AC67D3AF19522D75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtLineItems" xlink:label="loc_us-gaap_ShortTermDebtLineItems_E13C5D01690052FD8FC327A3C7F25F67" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_30CBF63C8C305C0FAB920C1A9CA1D115" xlink:to="loc_us-gaap_ShortTermDebtLineItems_E13C5D01690052FD8FC327A3C7F25F67" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtPercentageBearingFixedInterestRate" xlink:label="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_5DA7DB0CAC445CD8AFF5ACDA28B4DF7D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtLineItems_E13C5D01690052FD8FC327A3C7F25F67" xlink:to="loc_us-gaap_ShortTermDebtPercentageBearingFixedInterestRate_5DA7DB0CAC445CD8AFF5ACDA28B4DF7D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_082A6D43E78B5D6CA3913E65CA3060D7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermDebtLineItems_E13C5D01690052FD8FC327A3C7F25F67" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_082A6D43E78B5D6CA3913E65CA3060D7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_AE4A1172BACEF3ADFB1AFA4A83B08A50" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable" xlink:label="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_331E5D0A30D77EBDFF2BFA4A83B0DCC2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_AE4A1172BACEF3ADFB1AFA4A83B08A50" xlink:to="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_331E5D0A30D77EBDFF2BFA4A83B0DCC2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_3AEADBA9F700B0E82B19FA4A83B0CA25" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_331E5D0A30D77EBDFF2BFA4A83B0DCC2" xlink:to="loc_srt_CounterpartyNameAxis_3AEADBA9F700B0E82B19FA4A83B0CA25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5FF5A1C942C60FA106C3FA4A83B0606B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_3AEADBA9F700B0E82B19FA4A83B0CA25" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5FF5A1C942C60FA106C3FA4A83B0606B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_BethesdaSecuritiesMember" xlink:label="loc_agnc_BethesdaSecuritiesMember_9EAAA274F48C8A7829A0FA4A83B1D349" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5FF5A1C942C60FA106C3FA4A83B0606B" xlink:to="loc_agnc_BethesdaSecuritiesMember_9EAAA274F48C8A7829A0FA4A83B1D349" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FICCMember" xlink:label="loc_agnc_FICCMember_0BC2DD00A71D9F20BBFCFA4A83B16A89" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5FF5A1C942C60FA106C3FA4A83B0606B" xlink:to="loc_agnc_FICCMember_0BC2DD00A71D9F20BBFCFA4A83B16A89" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_3B26CAC4D878810C52F9FA4A83B2C35A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_331E5D0A30D77EBDFF2BFA4A83B0DCC2" xlink:to="loc_us-gaap_FinancialInstrumentAxis_3B26CAC4D878810C52F9FA4A83B2C35A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E7CF16F0421875A4EABCFA4A83B243C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_3B26CAC4D878810C52F9FA4A83B2C35A" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E7CF16F0421875A4EABCFA4A83B243C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_4B52501C71BE22D7686BFA4A83B22CE7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E7CF16F0421875A4EABCFA4A83B243C5" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_4B52501C71BE22D7686BFA4A83B22CE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_67599C21EE0520BA1C0AFA4A83B3DF6F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_331E5D0A30D77EBDFF2BFA4A83B0DCC2" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_67599C21EE0520BA1C0AFA4A83B3DF6F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D8574A4B233047F66FD2FA4A83B381C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_67599C21EE0520BA1C0AFA4A83B3DF6F" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D8574A4B233047F66FD2FA4A83B381C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_A5DC28E6DB80DA5B4004FA4A83B3C330" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D8574A4B233047F66FD2FA4A83B381C6" xlink:to="loc_us-gaap_MaturityOvernightMember_A5DC28E6DB80DA5B4004FA4A83B3C330" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_177BCF9971DD509130BCFA4A83B4DCAC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_D8574A4B233047F66FD2FA4A83B381C6" xlink:to="loc_us-gaap_ForwardContractsMember_177BCF9971DD509130BCFA4A83B4DCAC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_0285CA08E66FB6A7E0EDFA4A83B4D04D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_331E5D0A30D77EBDFF2BFA4A83B0DCC2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_0285CA08E66FB6A7E0EDFA4A83B4D04D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_B03A4454C4CC06950C17FA4A83B4A548" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_0285CA08E66FB6A7E0EDFA4A83B4D04D" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_B03A4454C4CC06950C17FA4A83B4A548" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" xlink:label="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_952B50A019E305D2C1D9FA4A83B41355" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_B03A4454C4CC06950C17FA4A83B4A548" xlink:to="loc_agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember_952B50A019E305D2C1D9FA4A83B41355" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_TBAandForwardSettlingAgencySecuritiesMember" xlink:label="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_A1A991E8179AE48378FBFA4A83B5D088" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_B03A4454C4CC06950C17FA4A83B4A548" xlink:to="loc_agnc_TBAandForwardSettlingAgencySecuritiesMember_A1A991E8179AE48378FBFA4A83B5D088" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAssetsSoldUnderAgreementsToRepurchaseTable_331E5D0A30D77EBDFF2BFA4A83B0DCC2" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_6F94CCEA3FEA1D7591F3FA4A83B58633" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_6F94CCEA3FEA1D7591F3FA4A83B58633" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_419135A568DDEDB361E9FA4A83B55413" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_419135A568DDEDB361E9FA4A83B55413" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DerivativeForwardSettlementValue" xlink:label="loc_agnc_DerivativeForwardSettlementValue_2B002A200F3839B48A78FA4A83B61DA7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_DerivativeForwardSettlementValue_2B002A200F3839B48A78FA4A83B61DA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_62BBF585B903AC8904C3FA4A83B6E17C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_62BBF585B903AC8904C3FA4A83B6E17C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PercentageofRepurchaseAgreementFunding" xlink:label="loc_agnc_PercentageofRepurchaseAgreementFunding_6E9298C5FE69AAEB57E7FA4A83B648A4" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_PercentageofRepurchaseAgreementFunding_6E9298C5FE69AAEB57E7FA4A83B648A4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_2C7FF9470605F75CAFB8FA4A83B6D131" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_2C7FF9470605F75CAFB8FA4A83B6D131" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageForwardStartDate" xlink:label="loc_agnc_WeightedAverageForwardStartDate_D34FF06D5BED97EDB3E2FA4A83B69A51" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_WeightedAverageForwardStartDate_D34FF06D5BED97EDB3E2FA4A83B69A51" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageForwardStartDays" xlink:label="loc_agnc_WeightedAverageForwardStartDays_A749E7ED3C0410F12A9EFA4A83B78D5F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_WeightedAverageForwardStartDays_A749E7ED3C0410F12A9EFA4A83B78D5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_6E3EB60A2410BA2C896CFA4A83B7345B" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_6E3EB60A2410BA2C896CFA4A83B7345B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_86DAB90A7949D63379DFFA4A83B7CC36" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_us-gaap_OtherLongTermDebt_86DAB90A7949D63379DFFA4A83B7CC36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_89B43F6650CD7D5B04A6FA4A83B72F1C" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_89B43F6650CD7D5B04A6FA4A83B72F1C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SpreadOverLibor" xlink:label="loc_agnc_SpreadOverLibor_572C4487EC08C5BBE02EFA4A83B7478D" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_SpreadOverLibor_572C4487EC08C5BBE02EFA4A83B7478D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_56459977C66159659935FA4A83B7DC64" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_56459977C66159659935FA4A83B7DC64" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageLifeOtherDebt" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_BB3AC163C12E2F51D2BEFA4A83B81604" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseLineItems_7F92775B93CB80AC0E02FA4A83B52963" xlink:to="loc_agnc_WeightedAverageLifeOtherDebt_BB3AC163C12E2F51D2BEFA4A83B81604" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_2BF2CD34C10A5DFD97D6C457A64D733B" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_0ECE930C8B7C50E186522F3E612A4EF4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_2BF2CD34C10A5DFD97D6C457A64D733B" xlink:to="loc_agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock_0ECE930C8B7C50E186522F3E612A4EF4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" xlink:label="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_D28D320D3297590EA3DA274F162A9510" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_2BF2CD34C10A5DFD97D6C457A64D733B" xlink:to="loc_agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock_D28D320D3297590EA3DA274F162A9510" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_859F0B45E60D583E8F0F7AA8E2989991" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_F406103750CE54D483C88AE332BF6810" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_859F0B45E60D583E8F0F7AA8E2989991" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_F406103750CE54D483C88AE332BF6810" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_36C50A0B774B3026C216F6F62FBC4E0C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4AC4B7C488EDE82C1122F6F62FBC9CC9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_36C50A0B774B3026C216F6F62FBC4E0C" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4AC4B7C488EDE82C1122F6F62FBC9CC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_717A2F874464F541FC16F6F62FBD9ACB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4AC4B7C488EDE82C1122F6F62FBC9CC9" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_717A2F874464F541FC16F6F62FBD9ACB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_2130316D4B2109D856EDF6F62FBDD223" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_717A2F874464F541FC16F6F62FBD9ACB" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_2130316D4B2109D856EDF6F62FBDD223" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_248444AE2650FB3F3375F6F62FBE75A1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_2130316D4B2109D856EDF6F62FBDD223" xlink:to="loc_us-gaap_InterestRateSwapMember_248444AE2650FB3F3375F6F62FBE75A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_E33611BA6F9328E5AB9CF6F62FBEA724" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4AC4B7C488EDE82C1122F6F62FBC9CC9" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_E33611BA6F9328E5AB9CF6F62FBEA724" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_BD0941966E34110938A8F6F62FBE12A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_E33611BA6F9328E5AB9CF6F62FBEA724" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_BD0941966E34110938A8F6F62FBE12A4" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_F2EB7C0F7DB28CF274A3F6F62FBE7222" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_BD0941966E34110938A8F6F62FBE12A4" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_F2EB7C0F7DB28CF274A3F6F62FBE7222" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0BC0C5FBB4C8BC292BF8F6F62FBFF748" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4AC4B7C488EDE82C1122F6F62FBC9CC9" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0BC0C5FBB4C8BC292BF8F6F62FBFF748" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_DBB61FCC12892822FB86F6F62FBF94C8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0BC0C5FBB4C8BC292BF8F6F62FBFF748" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_DBB61FCC12892822FB86F6F62FBF94C8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AgencySecuritiesMember" xlink:label="loc_us-gaap_AgencySecuritiesMember_B4FE0E3138B079F70CE9F6F62FBF68D0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_DBB61FCC12892822FB86F6F62FBF94C8" xlink:to="loc_us-gaap_AgencySecuritiesMember_B4FE0E3138B079F70CE9F6F62FBF68D0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4AC4B7C488EDE82C1122F6F62FBC9CC9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_6357D4F10A00E56A0C8CF6F62FC0AF1E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_6357D4F10A00E56A0C8CF6F62FC0AF1E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge" xlink:label="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_AD41FDAAA8B85235E70FF6F62FC0FEEC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:to="loc_us-gaap_DeferredGainLossOnDiscontinuationOfInterestRateFairValueHedge_AD41FDAAA8B85235E70FF6F62FC0FEEC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_69CF74AE6F1D825CC6DCF6F62FC00163" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_69CF74AE6F1D825CC6DCF6F62FC00163" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" xlink:label="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_514D688BE84626B7D6D4F6F62FC06A80" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:to="loc_agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization_514D688BE84626B7D6D4F6F62FC06A80" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_CC34A506B471D98A046EF6F62FC1F9C8" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_CC34A506B471D98A046EF6F62FC1F9C8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_C395795B5A1CEA1080E3F6F62FC1D367" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A046E5AD154C67F590BCF6F62FBF44D8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_C395795B5A1CEA1080E3F6F62FC1D367" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_899FE2FDADC6B852153CF6F6292DC0E0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_59CAAF0B7E36A757FDA0F6F6292D3CB7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_899FE2FDADC6B852153CF6F6292DC0E0" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_59CAAF0B7E36A757FDA0F6F6292D3CB7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_ACB0AA4FF81B882BA77FF6F6292DB978" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_59CAAF0B7E36A757FDA0F6F6292D3CB7" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_ACB0AA4FF81B882BA77FF6F6292DB978" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_6BDF0BC6C4ACA2805851F6F6292DB948" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_ACB0AA4FF81B882BA77FF6F6292DB978" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_6BDF0BC6C4ACA2805851F6F6292DB948" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CommonStockAtTheMarketSaleAgreementMember" xlink:label="loc_agnc_CommonStockAtTheMarketSaleAgreementMember_B4C568044CE82652031FF6F6292E0651" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_6BDF0BC6C4ACA2805851F6F6292DB948" xlink:to="loc_agnc_CommonStockAtTheMarketSaleAgreementMember_B4C568044CE82652031FF6F6292E0651" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_624A326FD9B159103B17F6F6292E5468" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_59CAAF0B7E36A757FDA0F6F6292D3CB7" xlink:to="loc_us-gaap_StatementClassOfStockAxis_624A326FD9B159103B17F6F6292E5468" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_C580F661C0060D69235AF6F6292F1043" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_624A326FD9B159103B17F6F6292E5468" xlink:to="loc_us-gaap_ClassOfStockDomain_C580F661C0060D69235AF6F6292F1043" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_4522B105320CF4A12F85F6F6292FF92E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_C580F661C0060D69235AF6F6292F1043" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_4522B105320CF4A12F85F6F6292FF92E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2B057DFD8ED42BF19CFCF6F6292FBEFF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_59CAAF0B7E36A757FDA0F6F6292D3CB7" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2B057DFD8ED42BF19CFCF6F6292FBEFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_B2BBD315A04C7DAAC7FEF6F6292F1B70" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2B057DFD8ED42BF19CFCF6F6292FBEFF" xlink:to="loc_us-gaap_EquityComponentDomain_B2BBD315A04C7DAAC7FEF6F6292F1B70" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9D88A3A2A7209BDB5875F6F62930C2C5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_59CAAF0B7E36A757FDA0F6F6292D3CB7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9D88A3A2A7209BDB5875F6F62930C2C5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_324D4719925A96DE26E4F6F629303A51" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9D88A3A2A7209BDB5875F6F62930C2C5" xlink:to="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_324D4719925A96DE26E4F6F629303A51" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3C95614F9D05F894335DF6F629309456" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9D88A3A2A7209BDB5875F6F62930C2C5" xlink:to="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3C95614F9D05F894335DF6F629309456" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_0DB555788B65244310A3F6F6293112EB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9D88A3A2A7209BDB5875F6F62930C2C5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_0DB555788B65244310A3F6F6293112EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_F47EFB455C1C6F42B2D2F6F62931243C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9D88A3A2A7209BDB5875F6F62930C2C5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_F47EFB455C1C6F42B2D2F6F62931243C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_106BA8C2800116C6E107F6F629312A15" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9D88A3A2A7209BDB5875F6F62930C2C5" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_106BA8C2800116C6E107F6F629312A15" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_C9D56E6F9B8F57498777130CA0E03835" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2144D146264850489F8951851BB3F13E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_C9D56E6F9B8F57498777130CA0E03835" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2144D146264850489F8951851BB3F13E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_A3E0D8F26B5555BA8A4CB8DCA11A7565" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2144D146264850489F8951851BB3F13E" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_A3E0D8F26B5555BA8A4CB8DCA11A7565" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_0DDE4AAB095D5B3E830F0ABC56F6DE38" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_A3E0D8F26B5555BA8A4CB8DCA11A7565" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_0DDE4AAB095D5B3E830F0ABC56F6DE38" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_B02E78C9296B57FDB397EFA2DBEC2CFB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_A3E0D8F26B5555BA8A4CB8DCA11A7565" xlink:to="loc_us-gaap_PlanNameDomain_B02E78C9296B57FDB397EFA2DBEC2CFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_342A49A3B1E9572AB5E68181AF2AEE26" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2144D146264850489F8951851BB3F13E" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_342A49A3B1E9572AB5E68181AF2AEE26" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_3112D1D4241355DAA1ADEEB588124861" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_342A49A3B1E9572AB5E68181AF2AEE26" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_3112D1D4241355DAA1ADEEB588124861" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_C582DCDABC3D51DE874476C4EC7E0BB2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_3112D1D4241355DAA1ADEEB588124861" xlink:to="loc_us-gaap_SubsequentEventMember_C582DCDABC3D51DE874476C4EC7E0BB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_042463AFAB9D5DC387A703F912589DBE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2144D146264850489F8951851BB3F13E" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_042463AFAB9D5DC387A703F912589DBE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_27582EE36890504CBC7C4C4AD0A4AA04" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_042463AFAB9D5DC387A703F912589DBE" xlink:to="loc_us-gaap_EquityComponentDomain_27582EE36890504CBC7C4C4AD0A4AA04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_5E3F238394FA5284991A64B101F8CD55" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_27582EE36890504CBC7C4C4AD0A4AA04" xlink:to="loc_us-gaap_CommonStockMember_5E3F238394FA5284991A64B101F8CD55" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2144D146264850489F8951851BB3F13E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_221459EFA9065583BB1A0B6EBAC5C605" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_221459EFA9065583BB1A0B6EBAC5C605" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_7E963F1EAA645EC3967402D57FDC6CDE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_7E963F1EAA645EC3967402D57FDC6CDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:label="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_653C795436475618A61609ECB5CB1118" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:to="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_653C795436475618A61609ECB5CB1118" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_147C815F9580556181D4CA7DF599BD2D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_147C815F9580556181D4CA7DF599BD2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_5B4D478AC0AA552080747785E99133D3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_5B4D478AC0AA552080747785E99133D3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" xlink:label="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_04C6E35EA51A5163A1E5D472E736D22D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:to="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_04C6E35EA51A5163A1E5D472E736D22D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_50E7FF93DEA755FBBFB1F164C705F91A" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0D9CCBC4EF225A68B48B3A8FC4674CBC" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_50E7FF93DEA755FBBFB1F164C705F91A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_3FDB3CF3CC8B5310B211F141E2DE3AFF" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_79422E1C59C85A18A37DDD1705F10896" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_3FDB3CF3CC8B5310B211F141E2DE3AFF" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_79422E1C59C85A18A37DDD1705F10896" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5A6D2735B63E527C826CD38CB009A2CB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_79422E1C59C85A18A37DDD1705F10896" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5A6D2735B63E527C826CD38CB009A2CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_871F22E0E19A5EA6B3DD3167211AFA9A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5A6D2735B63E527C826CD38CB009A2CB" xlink:to="loc_us-gaap_ClassOfStockDomain_871F22E0E19A5EA6B3DD3167211AFA9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredClassBMember" xlink:label="loc_us-gaap_PreferredClassBMember_077C8365ADE2534B8BA720582C79BFD4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_871F22E0E19A5EA6B3DD3167211AFA9A" xlink:to="loc_us-gaap_PreferredClassBMember_077C8365ADE2534B8BA720582C79BFD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_1DA6100BC7535EA48DD6065647EBF635" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_871F22E0E19A5EA6B3DD3167211AFA9A" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_1DA6100BC7535EA48DD6065647EBF635" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_3B2F6F411C725930B69949A92DD414D3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_871F22E0E19A5EA6B3DD3167211AFA9A" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_3B2F6F411C725930B69949A92DD414D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="loc_us-gaap_SeriesEPreferredStockMember_9B4F9550202D54D48945206B0DB3D366" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_871F22E0E19A5EA6B3DD3167211AFA9A" xlink:to="loc_us-gaap_SeriesEPreferredStockMember_9B4F9550202D54D48945206B0DB3D366" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_E955CD2BEA2A560B8115D71C0D1E0203" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_79422E1C59C85A18A37DDD1705F10896" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_E955CD2BEA2A560B8115D71C0D1E0203" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_4876338596125E32A388DEC9AD8BEFFC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_E955CD2BEA2A560B8115D71C0D1E0203" xlink:to="loc_us-gaap_EquityComponentDomain_4876338596125E32A388DEC9AD8BEFFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_70EB3429D9545880A6DE8AFE519E57E6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_79422E1C59C85A18A37DDD1705F10896" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_70EB3429D9545880A6DE8AFE519E57E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStock" xlink:label="loc_us-gaap_DividendsPreferredStock_BE09B4EEB7FC5C43B9A5D1DF6312BB52" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_70EB3429D9545880A6DE8AFE519E57E6" xlink:to="loc_us-gaap_DividendsPreferredStock_BE09B4EEB7FC5C43B9A5D1DF6312BB52" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:label="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_A0D70EB1B94E5C3AB7519DE14CC535A4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_70EB3429D9545880A6DE8AFE519E57E6" xlink:to="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_A0D70EB1B94E5C3AB7519DE14CC535A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCommonStock" xlink:label="loc_us-gaap_DividendsCommonStock_07356D7BB1B851618A56FA10980479A5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_70EB3429D9545880A6DE8AFE519E57E6" xlink:to="loc_us-gaap_DividendsCommonStock_07356D7BB1B851618A56FA10980479A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_CA0FFD4F48805E8391EBC020BD1904B6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_70EB3429D9545880A6DE8AFE519E57E6" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_CA0FFD4F48805E8391EBC020BD1904B6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_34C1990EF36A5066951288A497C29BA6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_65BF2218A4BC528D9D8F67CA41B6D22C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_34C1990EF36A5066951288A497C29BA6" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_65BF2218A4BC528D9D8F67CA41B6D22C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_E863BF3FFDF55DC387C4DC31B0036F96" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_65BF2218A4BC528D9D8F67CA41B6D22C" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_E863BF3FFDF55DC387C4DC31B0036F96" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_A6540EA2D1B958379C78DC3C75AEBECB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_E863BF3FFDF55DC387C4DC31B0036F96" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_A6540EA2D1B958379C78DC3C75AEBECB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_FollowOnPublicOfferingMember" xlink:label="loc_agnc_FollowOnPublicOfferingMember_D9202A430CA153D29BB492542EA8188A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_A6540EA2D1B958379C78DC3C75AEBECB" xlink:to="loc_agnc_FollowOnPublicOfferingMember_D9202A430CA153D29BB492542EA8188A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_CD876CDEF5C05DF7BACF3FB7425E8406" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_65BF2218A4BC528D9D8F67CA41B6D22C" xlink:to="loc_us-gaap_ClassOfStockLineItems_CD876CDEF5C05DF7BACF3FB7425E8406" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_7BE2A74E518A5F61B3508AA6E9D79C07" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_CD876CDEF5C05DF7BACF3FB7425E8406" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_7BE2A74E518A5F61B3508AA6E9D79C07" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_6189BBB1ADEC520998427FE7E2D97BB3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_CD876CDEF5C05DF7BACF3FB7425E8406" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_6189BBB1ADEC520998427FE7E2D97BB3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_F27879577D5B52C58A4A6F3592A3B9E0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_CD876CDEF5C05DF7BACF3FB7425E8406" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_F27879577D5B52C58A4A6F3592A3B9E0" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityLongTermIncentivePlanDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_ECC598F0E51954D78CC1463AB4F44E9D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ACB5C1E84D5A56E78B1724C7F207D650" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_ECC598F0E51954D78CC1463AB4F44E9D" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ACB5C1E84D5A56E78B1724C7F207D650" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_TitleOfIndividualAxis" xlink:label="loc_srt_TitleOfIndividualAxis_F7567BA47E5458BABECCA3DAF6CD13CF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ACB5C1E84D5A56E78B1724C7F207D650" xlink:to="loc_srt_TitleOfIndividualAxis_F7567BA47E5458BABECCA3DAF6CD13CF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_892E82E889D8522F90F4FA41E4981D32" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualAxis_F7567BA47E5458BABECCA3DAF6CD13CF" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_892E82E889D8522F90F4FA41E4981D32" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_31D4814FA9E15A9E90D3A49590CE892A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ACB5C1E84D5A56E78B1724C7F207D650" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_31D4814FA9E15A9E90D3A49590CE892A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_3D8B7FF510F751F0807C23DB238078CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_31D4814FA9E15A9E90D3A49590CE892A" xlink:to="loc_us-gaap_RelatedPartyDomain_3D8B7FF510F751F0807C23DB238078CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_C4A8FF2D40AC5665BC4F3EA9058B536A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ACB5C1E84D5A56E78B1724C7F207D650" xlink:to="loc_us-gaap_AwardTypeAxis_C4A8FF2D40AC5665BC4F3EA9058B536A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E635456688EF56A9BBEEC569F48FF4B0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_C4A8FF2D40AC5665BC4F3EA9058B536A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E635456688EF56A9BBEEC569F48FF4B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9628D3DE50EE5130B5B8A11D32FEE2B7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ACB5C1E84D5A56E78B1724C7F207D650" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9628D3DE50EE5130B5B8A11D32FEE2B7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_FBD0FD07BE78232B526CFB1F6E957531" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6098B2CCF3493D4FC8D4FB1F6E95B265" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_FBD0FD07BE78232B526CFB1F6E957531" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6098B2CCF3493D4FC8D4FB1F6E95B265" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_078A7581AFD99BE706E8FB1F6E96D17A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6098B2CCF3493D4FC8D4FB1F6E95B265" xlink:to="loc_us-gaap_VariableRateAxis_078A7581AFD99BE706E8FB1F6E96D17A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_E842F73F35A1C155C63DFB1F6E97988D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_078A7581AFD99BE706E8FB1F6E96D17A" xlink:to="loc_us-gaap_VariableRateDomain_E842F73F35A1C155C63DFB1F6E97988D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis_9747D1F1A2DB42F10E9CFB1F6E97422C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6098B2CCF3493D4FC8D4FB1F6E95B265" xlink:to="loc_us-gaap_PreferredUnitsByNameAxis_9747D1F1A2DB42F10E9CFB1F6E97422C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="loc_us-gaap_PreferredUnitsClassDomain_C1EF615439C910E3414DFB1F6E97B7A3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis_9747D1F1A2DB42F10E9CFB1F6E97422C" xlink:to="loc_us-gaap_PreferredUnitsClassDomain_C1EF615439C910E3414DFB1F6E97B7A3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DepositaryShareMember" xlink:label="loc_agnc_DepositaryShareMember_347704131149DDEAAF07FB1F6E97E1D0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsClassDomain_C1EF615439C910E3414DFB1F6E97B7A3" xlink:to="loc_agnc_DepositaryShareMember_347704131149DDEAAF07FB1F6E97E1D0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_BC4C914171D1C650428DFB1F6E97D993" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6098B2CCF3493D4FC8D4FB1F6E95B265" xlink:to="loc_us-gaap_StatementClassOfStockAxis_BC4C914171D1C650428DFB1F6E97D993" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_BC4C914171D1C650428DFB1F6E97D993" xlink:to="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_FBBD1C7C916007F1F3ACFB1F6E9863D2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_FBBD1C7C916007F1F3ACFB1F6E9863D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_4E6FAD65CCA819E48176FB1F6E98967C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_4E6FAD65CCA819E48176FB1F6E98967C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_F450D436175C94EA818BFB1F6E99F621" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_F450D436175C94EA818BFB1F6E99F621" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_F89A00F76D72D8A5E4C2FB1F6E994268" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_F89A00F76D72D8A5E4C2FB1F6E994268" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="loc_us-gaap_SeriesEPreferredStockMember_CDC554F41214B6925872FB1F6E991E79" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:to="loc_us-gaap_SeriesEPreferredStockMember_CDC554F41214B6925872FB1F6E991E79" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesFPreferredStockMember" xlink:label="loc_us-gaap_SeriesFPreferredStockMember_9B6430806EE4DEF95A5CFB1F6E992B4C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_5898F26A62FB14F8E6CBFB1F6E98679F" xlink:to="loc_us-gaap_SeriesFPreferredStockMember_9B6430806EE4DEF95A5CFB1F6E992B4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6098B2CCF3493D4FC8D4FB1F6E95B265" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockBValueIssued" xlink:label="loc_agnc_PreferredStockBValueIssued_A877478002631A53AECAFB1F6E9A9834" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockBValueIssued_A877478002631A53AECAFB1F6E9A9834" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockBLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockBLiquidationPreferenceValue_C22F48274120AF00DD4AFB1F6E9A669C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockBLiquidationPreferenceValue_C22F48274120AF00DD4AFB1F6E9A669C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockPercentInterestPerShare" xlink:label="loc_agnc_PreferredStockPercentInterestPerShare_4CE3EE0C20D5515724A1FB1F6E9AD618" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockPercentInterestPerShare_4CE3EE0C20D5515724A1FB1F6E9AD618" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_1DC1256A72275FBE35D6FB1F6E9B1830" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_1DC1256A72275FBE35D6FB1F6E9B1830" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_6CDA360231FB31B5480EFB1F6E9BE0CF" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_PreferredStockDividendRatePercentage_6CDA360231FB31B5480EFB1F6E9BE0CF" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockEValueIssued" xlink:label="loc_agnc_PreferredStockEValueIssued_B48144BB5220346D7334FB1F6E9B2D95" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockEValueIssued_B48144BB5220346D7334FB1F6E9B2D95" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockELiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockELiquidationPreferenceValue_AC98108DE2D2858CDDD9FB1F6E9B5A6C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockELiquidationPreferenceValue_AC98108DE2D2858CDDD9FB1F6E9B5A6C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockDividendPaymentRateVariableRateSpread" xlink:label="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_D18A1C8078D0BED27BD7FB1F6E9BF19D" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_D18A1C8078D0BED27BD7FB1F6E9BF19D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreference" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_A69DDEA28590D94D0135FB1F6E9C8E0B" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_PreferredStockLiquidationPreference_A69DDEA28590D94D0135FB1F6E9C8E0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_6ACF2DBB398A51E55C0BFB1F6E9CCECA" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_PreferredStockSharesIssued_6ACF2DBB398A51E55C0BFB1F6E9CCECA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockFValueIssued" xlink:label="loc_agnc_PreferredStockFValueIssued_7C1A2145E71047381CFFFB1F6E9CA5FE" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockFValueIssued_7C1A2145E71047381CFFFB1F6E9CA5FE" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockDValueIssued" xlink:label="loc_agnc_PreferredStockDValueIssued_CBE77D2BFE1EF8B49748FB1F6E9CC007" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockDValueIssued_CBE77D2BFE1EF8B49748FB1F6E9CC007" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockDLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockDLiquidationPreferenceValue_0955ABF97234FC5771A1FB1F6E9C374D" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockDLiquidationPreferenceValue_0955ABF97234FC5771A1FB1F6E9C374D" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockAuthorizedButNotIssued" xlink:label="loc_agnc_PreferredStockAuthorizedButNotIssued_669F351715E4F45A33FEFB1F6E9C890A" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockAuthorizedButNotIssued_669F351715E4F45A33FEFB1F6E9C890A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_EF4F6ADF0C6D7744EA65FB1F6E9D0247" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfRedeemablePreferredStock_EF4F6ADF0C6D7744EA65FB1F6E9D0247" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_55C7B195D500D4181483FB1F6E9D6325" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_55C7B195D500D4181483FB1F6E9D6325" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockCValueIssued" xlink:label="loc_agnc_PreferredStockCValueIssued_B7834FE71253113C673CFB1F6E9D5D72" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockCValueIssued_B7834FE71253113C673CFB1F6E9D5D72" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockCLiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockCLiquidationPreferenceValue_0AB4CCC2472218A2CBC9FB1F6E9DF636" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_agnc_PreferredStockCLiquidationPreferenceValue_0AB4CCC2472218A2CBC9FB1F6E9DF636" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_D898117C66B56EFD146CFB1F6E9DD1B1" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_PreferredStockValue_D898117C66B56EFD146CFB1F6E9DD1B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_544F32EB52D7EECA8D86FB1F6E9E6F22" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_310C86C6E5FE45A7C03FFB1F6E9916FA" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_544F32EB52D7EECA8D86FB1F6E9E6F22" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_42847DAAD96A3DD8B456FB1F6E9EF3F9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_FBD0FD07BE78232B526CFB1F6E957531" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_42847DAAD96A3DD8B456FB1F6E9EF3F9" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ScheduleofDividendsDeclaredAbstract" xlink:label="loc_agnc_ScheduleofDividendsDeclaredAbstract_5D27B6726381526194007676FFC2AABA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D470F143F60A5C82AA1D23D2D15CBEDD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_ScheduleofDividendsDeclaredAbstract_5D27B6726381526194007676FFC2AABA" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D470F143F60A5C82AA1D23D2D15CBEDD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_DEC5125BAB115BCE8016DF61967101B6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D470F143F60A5C82AA1D23D2D15CBEDD" xlink:to="loc_us-gaap_StatementClassOfStockAxis_DEC5125BAB115BCE8016DF61967101B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_84F9EA3383EB5B178945AE4E8F7CDBC2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_DEC5125BAB115BCE8016DF61967101B6" xlink:to="loc_us-gaap_ClassOfStockDomain_84F9EA3383EB5B178945AE4E8F7CDBC2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredClassBMember" xlink:label="loc_us-gaap_PreferredClassBMember_A97BADB6E2BB5989BA435F127A82C831" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_84F9EA3383EB5B178945AE4E8F7CDBC2" xlink:to="loc_us-gaap_PreferredClassBMember_A97BADB6E2BB5989BA435F127A82C831" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_FE23392750435EF38560CA1601F3DABD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_84F9EA3383EB5B178945AE4E8F7CDBC2" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_FE23392750435EF38560CA1601F3DABD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_7CDE7EBBFFFD5B1189D4D5B7C0B1D6A3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_84F9EA3383EB5B178945AE4E8F7CDBC2" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_7CDE7EBBFFFD5B1189D4D5B7C0B1D6A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="loc_us-gaap_SeriesEPreferredStockMember_94C5C51E6ED455F3B2AD891CD9D60EC7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_84F9EA3383EB5B178945AE4E8F7CDBC2" xlink:to="loc_us-gaap_SeriesEPreferredStockMember_94C5C51E6ED455F3B2AD891CD9D60EC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1724300DB68C5E4BA82BD64FDB0A3F40" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D470F143F60A5C82AA1D23D2D15CBEDD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1724300DB68C5E4BA82BD64FDB0A3F40" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStock" xlink:label="loc_us-gaap_DividendsPreferredStock_23485D69D7A85660B7553C8DDE493D39" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1724300DB68C5E4BA82BD64FDB0A3F40" xlink:to="loc_us-gaap_DividendsPreferredStock_23485D69D7A85660B7553C8DDE493D39" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePerDollarAmount" xlink:label="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_9D66B4ECE1C45DCAAF9E66DA90F84BD5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1724300DB68C5E4BA82BD64FDB0A3F40" xlink:to="loc_us-gaap_PreferredStockDividendRatePerDollarAmount_9D66B4ECE1C45DCAAF9E66DA90F84BD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCommonStock" xlink:label="loc_us-gaap_DividendsCommonStock_99E4995583D955D28C52E72EFCDD9093" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1724300DB68C5E4BA82BD64FDB0A3F40" xlink:to="loc_us-gaap_DividendsCommonStock_99E4995583D955D28C52E72EFCDD9093" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_5DE30D5E635F5FBAB11A5B5F64C69651" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1724300DB68C5E4BA82BD64FDB0A3F40" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_5DE30D5E635F5FBAB11A5B5F64C69651" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/StockholdersEquityTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_6A22005ED9503AEC9AD1E53E2E5B0D66" xlink:type="locator" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockTableTextBlock" xlink:label="loc_agnc_PreferredStockTableTextBlock_E9D9FDCAE5CA51038F4BE53E2E5B3D93" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_6A22005ED9503AEC9AD1E53E2E5B0D66" xlink:to="loc_agnc_PreferredStockTableTextBlock_E9D9FDCAE5CA51038F4BE53E2E5B3D93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfStockByClassTextBlock" xlink:label="loc_us-gaap_ScheduleOfStockByClassTextBlock_56AB36F2C209EF102C32E53E2E5BC88F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_6A22005ED9503AEC9AD1E53E2E5B0D66" xlink:to="loc_us-gaap_ScheduleOfStockByClassTextBlock_56AB36F2C209EF102C32E53E2E5BC88F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsDeclaredTableTextBlock" xlink:label="loc_us-gaap_DividendsDeclaredTableTextBlock_2980CB85E788414B7A56E53E2E5BB960" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_6A22005ED9503AEC9AD1E53E2E5B0D66" xlink:to="loc_us-gaap_DividendsDeclaredTableTextBlock_2980CB85E788414B7A56E53E2E5BB960" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_CA5CE816EFEF8BCB6C77E53E2E5C602D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_6A22005ED9503AEC9AD1E53E2E5B0D66" xlink:to="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_CA5CE816EFEF8BCB6C77E53E2E5C602D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SubsequentEvent" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_C4C8DAA023235CE6B131EDA24E9411F9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_9F35E94B3FD0590C99450109E072B66A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_C4C8DAA023235CE6B131EDA24E9411F9" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_9F35E94B3FD0590C99450109E072B66A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_CF0824B75941717CAB15F7025545ADF0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_A7BFDA609F60C13AC687F70255453BD5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_CF0824B75941717CAB15F7025545ADF0" xlink:to="loc_us-gaap_SubsequentEventTable_A7BFDA609F60C13AC687F70255453BD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="loc_us-gaap_PreferredUnitsByNameAxis_742E1763146F6E228B36F7025545C101" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_A7BFDA609F60C13AC687F70255453BD5" xlink:to="loc_us-gaap_PreferredUnitsByNameAxis_742E1763146F6E228B36F7025545C101" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="loc_us-gaap_PreferredUnitsClassDomain_0BC2A9C3314C926E20A6F7025546022C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsByNameAxis_742E1763146F6E228B36F7025545C101" xlink:to="loc_us-gaap_PreferredUnitsClassDomain_0BC2A9C3314C926E20A6F7025546022C" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DepositaryShareMember" xlink:label="loc_agnc_DepositaryShareMember_F89521E876CB07F86FF7F70255465914" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PreferredUnitsClassDomain_0BC2A9C3314C926E20A6F7025546022C" xlink:to="loc_agnc_DepositaryShareMember_F89521E876CB07F86FF7F70255465914" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_9E7579438F5567218BEDF7025546A524" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_A7BFDA609F60C13AC687F70255453BD5" xlink:to="loc_us-gaap_StatementClassOfStockAxis_9E7579438F5567218BEDF7025546A524" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_3C1DE9BD39D0B626F522F70255470242" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_9E7579438F5567218BEDF7025546A524" xlink:to="loc_us-gaap_ClassOfStockDomain_3C1DE9BD39D0B626F522F70255470242" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesFPreferredStockMember" xlink:label="loc_us-gaap_SeriesFPreferredStockMember_DB0B3E7A7AE0BB3A202FF70255470C43" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_3C1DE9BD39D0B626F522F70255470242" xlink:to="loc_us-gaap_SeriesFPreferredStockMember_DB0B3E7A7AE0BB3A202FF70255470C43" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_D543BF074F3B49EBB120F70255472808" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_A7BFDA609F60C13AC687F70255453BD5" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_D543BF074F3B49EBB120F70255472808" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_4FAEB229C47F12AB6629F7025547D3F4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_D543BF074F3B49EBB120F70255472808" xlink:to="loc_us-gaap_EquityComponentDomain_4FAEB229C47F12AB6629F7025547D3F4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_09C4DB54A8317822C7B5F702554D7E36" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_4FAEB229C47F12AB6629F7025547D3F4" xlink:to="loc_us-gaap_CommonStockMember_09C4DB54A8317822C7B5F702554D7E36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_A6D98DCCAD1A62D3AB99F702554D5C78" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_A7BFDA609F60C13AC687F70255453BD5" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_A6D98DCCAD1A62D3AB99F702554D5C78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_D4CFA9E8DC7B7C3BF848F702554DF3F9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_A6D98DCCAD1A62D3AB99F702554D5C78" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_D4CFA9E8DC7B7C3BF848F702554DF3F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_A7ACD08DEEE5C683423FF702554ED60E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_D4CFA9E8DC7B7C3BF848F702554DF3F9" xlink:to="loc_us-gaap_SubsequentEventMember_A7ACD08DEEE5C683423FF702554ED60E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_A7BFDA609F60C13AC687F70255453BD5" xlink:to="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_ADC8DD554AB1A0E7D987F702554E152A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_ADC8DD554AB1A0E7D987F702554E152A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_1B17A68BD1C987FC3882F702554F7EE5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_PreferredStockDividendRatePercentage_1B17A68BD1C987FC3882F702554F7EE5" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockDValueIssued" xlink:label="loc_agnc_PreferredStockDValueIssued_B877A0C45BCE51459A25F702554F1139" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_agnc_PreferredStockDValueIssued_B877A0C45BCE51459A25F702554F1139" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockEValueIssued" xlink:label="loc_agnc_PreferredStockEValueIssued_E34EEBFF609A93B020E8F702554F8ACC" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_agnc_PreferredStockEValueIssued_E34EEBFF609A93B020E8F702554F8ACC" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockDividendPaymentRateVariableRateSpread" xlink:label="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_6C97C419CBF06B2F0D85F702554F7BDB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_agnc_PreferredStockDividendPaymentRateVariableRateSpread_6C97C419CBF06B2F0D85F702554F7BDB" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_PreferredStockELiquidationPreferenceValue" xlink:label="loc_agnc_PreferredStockELiquidationPreferenceValue_10F51FCBA24591F49BD7F702554F638C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_agnc_PreferredStockELiquidationPreferenceValue_10F51FCBA24591F49BD7F702554F638C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_9BAC35ECF4595F206771F70255503A74" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_PreferredStockSharesIssued_9BAC35ECF4595F206771F70255503A74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="loc_us-gaap_DividendsPreferredStockCash_B5F8D7F0CC583551F63DF70255502B47" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_DividendsPreferredStockCash_B5F8D7F0CC583551F63DF70255502B47" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendPreferenceOrRestrictions" xlink:label="loc_us-gaap_PreferredStockDividendPreferenceOrRestrictions_8736EE94FE21DA7D4906F70255509BBB" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_PreferredStockDividendPreferenceOrRestrictions_8736EE94FE21DA7D4906F70255509BBB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_4425E06927AA04F61D21F7025550AB69" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_4425E06927AA04F61D21F7025550AB69" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_7C44936F880CCB542DF7F702555009F5" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_7C44936F880CCB542DF7F702555009F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_05E6492A2BF67E262910F702555027EB" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_05E6492A2BF67E262910F702555027EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_60D3C46A5D647D0AC83FF70255517168" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_GainLossOnContractTermination_60D3C46A5D647D0AC83FF70255517168" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_A1A29BD45553856D0F7EF70255511326" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_A1A29BD45553856D0F7EF70255511326" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_D72E027A8A2D23F9CFCAF70255513FC3" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_D72E027A8A2D23F9CFCAF70255513FC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockLiquidationPreference" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_F23E556A9B01C35EE67EF70255517A1A" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_PreferredStockLiquidationPreference_F23E556A9B01C35EE67EF70255517A1A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_6F098DBC31D794BD1003F7025552C7E4" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance_6F098DBC31D794BD1003F7025552C7E4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_F0E6422A4D8C1B11BA45F702C98B5BA1" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_F0E6422A4D8C1B11BA45F702C98B5BA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_D05B90B780F87E4E78AEF7047DCE71C3" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_D05B90B780F87E4E78AEF7047DCE71C3" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" xlink:label="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_06470269F47FB1AADC61F7055F3549DF" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_FF09098BF4C783D51035F702554EC463" xlink:to="loc_agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare_06470269F47FB1AADC61F7055F3549DF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_229533FA15495B149AD14FF3DECE91F9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_A7D786CDE06F56938C57E24935A34890" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_229533FA15495B149AD14FF3DECE91F9" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_A7D786CDE06F56938C57E24935A34890" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_42B709D1A0E855478D4C0A26A35C8805" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EB297DF266F54E2A9B0B0BFB29155B3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42B709D1A0E855478D4C0A26A35C8805" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EB297DF266F54E2A9B0B0BFB29155B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_6671925B67B7540384E288A5A57C1496" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EB297DF266F54E2A9B0B0BFB29155B3" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_6671925B67B7540384E288A5A57C1496" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_FCC6FDEF76AC51DAA27D7F1C30B2C0CD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_6671925B67B7540384E288A5A57C1496" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_FCC6FDEF76AC51DAA27D7F1C30B2C0CD" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" xlink:label="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_387C735B0D865058B44338FFDC49D4B2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_FCC6FDEF76AC51DAA27D7F1C30B2C0CD" xlink:to="loc_agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember_387C735B0D865058B44338FFDC49D4B2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_114FB042586B563496C247156EC02296" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EB297DF266F54E2A9B0B0BFB29155B3" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_114FB042586B563496C247156EC02296" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_17BF6693D85450C8974CFD8F8F187F07" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_114FB042586B563496C247156EC02296" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_17BF6693D85450C8974CFD8F8F187F07" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_808434B2684551898ED3A03AC31D5D5D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_114FB042586B563496C247156EC02296" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_808434B2684551898ED3A03AC31D5D5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_048B55E1908F5B65B566361B67C1689B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_114FB042586B563496C247156EC02296" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_048B55E1908F5B65B566361B67C1689B" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestIncomePolicyTextBlock" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_88F66F0B52BE54158C4DBB9ADF56E182" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_114FB042586B563496C247156EC02296" xlink:to="loc_agnc_InterestIncomePolicyTextBlock_88F66F0B52BE54158C4DBB9ADF56E182" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ManagementAgreementTextBlock" xlink:label="loc_agnc_ManagementAgreementTextBlock_1AEE0D9F318C59E19AE8C8D7B0DCA836" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_114FB042586B563496C247156EC02296" xlink:to="loc_agnc_ManagementAgreementTextBlock_1AEE0D9F318C59E19AE8C8D7B0DCA836" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_771C9A67CFC352178C38C9D1690D8D80" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_11C17541E8F75577ADE985C51148544E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_771C9A67CFC352178C38C9D1690D8D80" xlink:to="loc_us-gaap_DerivativeTable_11C17541E8F75577ADE985C51148544E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_F253BAEEE2D0580E8825DDD6AF949118" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11C17541E8F75577ADE985C51148544E" xlink:to="loc_srt_RangeAxis_F253BAEEE2D0580E8825DDD6AF949118" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_0A5F7934150751B386BCABFC0107C2B2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_F253BAEEE2D0580E8825DDD6AF949118" xlink:to="loc_srt_RangeMember_0A5F7934150751B386BCABFC0107C2B2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_DD066F6C6A0E5CDD8EAEAA8DC3CB7E31" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11C17541E8F75577ADE985C51148544E" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_DD066F6C6A0E5CDD8EAEAA8DC3CB7E31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_804F55CCD6F0552496DA4C6CDC2062F6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_DD066F6C6A0E5CDD8EAEAA8DC3CB7E31" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_804F55CCD6F0552496DA4C6CDC2062F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_7B77FB1DBFFE5E24B4FB3FCE3AA6192B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_804F55CCD6F0552496DA4C6CDC2062F6" xlink:to="loc_us-gaap_InterestRateSwapMember_7B77FB1DBFFE5E24B4FB3FCE3AA6192B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_CE08193788145EE1A04DEFAC5344090F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_11C17541E8F75577ADE985C51148544E" xlink:to="loc_us-gaap_DerivativeLineItems_CE08193788145EE1A04DEFAC5344090F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_E99E68F567145959A11C5083091218A7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_CE08193788145EE1A04DEFAC5344090F" xlink:to="loc_us-gaap_GainLossOnContractTermination_E99E68F567145959A11C5083091218A7" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_RequiredAnnualDistributionOfTaxableNetIncome" xlink:label="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_79BB5130246859CBA70161BE29A4244E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_CE08193788145EE1A04DEFAC5344090F" xlink:to="loc_agnc_RequiredAnnualDistributionOfTaxableNetIncome_79BB5130246859CBA70161BE29A4244E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_2DED6E4787985E82935FB6061AA7EDDE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_CE08193788145EE1A04DEFAC5344090F" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_2DED6E4787985E82935FB6061AA7EDDE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_1BC6EE71EAF35C489AC7756E86DD65CC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_928B5231635454828E2F398048C61407" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_1BC6EE71EAF35C489AC7756E86DD65CC" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_928B5231635454828E2F398048C61407" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_82663F4709D6540CBC7BA1A628E878B2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_928B5231635454828E2F398048C61407" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_82663F4709D6540CBC7BA1A628E878B2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_E94C0C985A2F5BD494C6550160EE559E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_82663F4709D6540CBC7BA1A628E878B2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_E94C0C985A2F5BD494C6550160EE559E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsAxis" xlink:label="loc_srt_ConsolidationItemsAxis_9B1CAD36CED351BC9B492CDC24E3D00D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_928B5231635454828E2F398048C61407" xlink:to="loc_srt_ConsolidationItemsAxis_9B1CAD36CED351BC9B492CDC24E3D00D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsDomain" xlink:label="loc_srt_ConsolidationItemsDomain_DD4580A1AD1B5418872B5A9523C9E917" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsAxis_9B1CAD36CED351BC9B492CDC24E3D00D" xlink:to="loc_srt_ConsolidationItemsDomain_DD4580A1AD1B5418872B5A9523C9E917" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_E461B2BCAEF05AFEA89F6F384D73DC40" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_928B5231635454828E2F398048C61407" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_E461B2BCAEF05AFEA89F6F384D73DC40" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_9941F751E9CB5C7E85C6D939B83C244B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_E461B2BCAEF05AFEA89F6F384D73DC40" xlink:to="loc_us-gaap_SegmentDomain_9941F751E9CB5C7E85C6D939B83C244B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_2ECE92AD8CB35C72BCBB14F68EDBF308" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_928B5231635454828E2F398048C61407" xlink:to="loc_srt_RangeAxis_2ECE92AD8CB35C72BCBB14F68EDBF308" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_105F2B7F044F58309AA8692956F9BDE1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_2ECE92AD8CB35C72BCBB14F68EDBF308" xlink:to="loc_srt_RangeMember_105F2B7F044F58309AA8692956F9BDE1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7AE632B774985A678BC1673B61ADC662" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_928B5231635454828E2F398048C61407" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7AE632B774985A678BC1673B61ADC662" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_100ADFA5DEEB5FA2A7AE12ABE6B914A8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7AE632B774985A678BC1673B61ADC662" xlink:to="loc_us-gaap_Goodwill_100ADFA5DEEB5FA2A7AE12ABE6B914A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_C90FD9DC3A0059C39C959E497183AAAF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7AE632B774985A678BC1673B61ADC662" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_C90FD9DC3A0059C39C959E497183AAAF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EA6294BD23C244DE4F5E54E24A1C6E1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EA6294BD23C244DE4F5E54E24A1C6E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_9374366D53C150EB7290E54E24A1BFD5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EA6294BD23C244DE4F5E54E24A1C6E1" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_9374366D53C150EB7290E54E24A1BFD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_E37AC342619B5226D8E0E54E24A205E3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_9374366D53C150EB7290E54E24A1BFD5" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_E37AC342619B5226D8E0E54E24A205E3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_4EA6294BD23C244DE4F5E54E24A1C6E1" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_188843CD7153095D5932E54E24A24624" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_188843CD7153095D5932E54E24A24624" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_08B070AF6F8DF5F23009E54E24A3F261" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_08B070AF6F8DF5F23009E54E24A3F261" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_D709D76419682CFF03D6E54E24A32434" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_D709D76419682CFF03D6E54E24A32434" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock" xlink:label="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_890DB480584F479A9D4DE54E24A32CED" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock_890DB480584F479A9D4DE54E24A32CED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_FB23647F0C0A7F3456D8E54E24A35EAE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_FB23647F0C0A7F3456D8E54E24A35EAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:label="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_CDFD007CEE1E7851DF83E54E24A456FA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_CDFD007CEE1E7851DF83E54E24A456FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_40D2E647C0974C1C1FA8E54E24A4ABF4" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_40D2E647C0974C1C1FA8E54E24A4ABF4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_0673F09113D94984838DE54E24A49A0F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_UseOfEstimates_0673F09113D94984838DE54E24A49A0F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_7139695D44C9756E4C08E54E24A596BD" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_7139695D44C9756E4C08E54E24A596BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_991CF57A1C3146516C0BE54E24A5CC7F" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_991CF57A1C3146516C0BE54E24A5CC7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4D95EF9777004FCB21CEE54E24A537A1" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4D95EF9777004FCB21CEE54E24A537A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GoodwillDisclosureTextBlock" xlink:label="loc_us-gaap_GoodwillDisclosureTextBlock_A9AE88E1ECD84F391B7AE54E24A50FA0" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_9F29ED18B243ED4243C1E54E24A2D70A" xlink:to="loc_us-gaap_GoodwillDisclosureTextBlock_A9AE88E1ECD84F391B7AE54E24A50FA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:label="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_1F595E17FCFBD239555DE54E24A52265" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_1F595E17FCFBD239555DE54E24A52265" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_7498276FCAD776144AE3E54E24A6A9F0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_7498276FCAD776144AE3E54E24A6A9F0" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_InterestIncomePolicyTextBlock" xlink:label="loc_agnc_InterestIncomePolicyTextBlock_E3764E5EEDD8DA25B154E54E24A62458" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_agnc_InterestIncomePolicyTextBlock_E3764E5EEDD8DA25B154E54E24A62458" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepurchaseAndResaleAgreementsPolicy" xlink:label="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_BCFF698EE9D5B7B70B8FE54E24A675F9" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_us-gaap_RepurchaseAndResaleAgreementsPolicy_BCFF698EE9D5B7B70B8FE54E24A675F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_6DF76E8FFCD5B18E24F6E54E24A7AEA1" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_6DF76E8FFCD5B18E24F6E54E24A7AEA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingencyDisclosures" xlink:label="loc_us-gaap_LossContingencyDisclosures_A15A3F0F69B18C5E7275E54E24A76BFE" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_us-gaap_LossContingencyDisclosures_A15A3F0F69B18C5E7275E54E24A76BFE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_422A5742C0A0990DFC5EE54E24A791DF" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_795898234737474B6D81E54E24A0C6D1" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_422A5742C0A0990DFC5EE54E24A791DF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="extended">
    <link:loc xlink:href="agnc-20200331.xsd#agnc_VariableInterestEntitiesAbstract" xlink:label="loc_agnc_VariableInterestEntitiesAbstract_9BBB046DCDD8556D81A8B7B6F82FACCC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_94C717E60DCD52E1B575A35F9E94700A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_agnc_VariableInterestEntitiesAbstract_9BBB046DCDD8556D81A8B7B6F82FACCC" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_94C717E60DCD52E1B575A35F9E94700A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_8A951C0636A05A9DA0F1F70BA1809A32" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_94C717E60DCD52E1B575A35F9E94700A" xlink:to="loc_us-gaap_DebtInstrumentAxis_8A951C0636A05A9DA0F1F70BA1809A32" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_B51C45DC876D51C4B7D1BEBD83A39909" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_8A951C0636A05A9DA0F1F70BA1809A32" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_B51C45DC876D51C4B7D1BEBD83A39909" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityLineItems" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_6D02E721DA1B5F4094D04610D101E552" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_94C717E60DCD52E1B575A35F9E94700A" xlink:to="loc_us-gaap_VariableInterestEntityLineItems_6D02E721DA1B5F4094D04610D101E552" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_EBDD1EBEE2225A52ACE3F14A772EB152" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_6D02E721DA1B5F4094D04610D101E552" xlink:to="loc_us-gaap_OtherLongTermDebt_EBDD1EBEE2225A52ACE3F14A772EB152" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:label="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_2E42A5A71DE954ABBA0F8C33CA85439A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_6D02E721DA1B5F4094D04610D101E552" xlink:to="loc_us-gaap_DebtInstrumentDescriptionOfVariableRateBasis_2E42A5A71DE954ABBA0F8C33CA85439A" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_SpreadOverLibor" xlink:label="loc_agnc_SpreadOverLibor_8E370092B280522B82616AB62AA9A609" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_6D02E721DA1B5F4094D04610D101E552" xlink:to="loc_agnc_SpreadOverLibor_8E370092B280522B82616AB62AA9A609" xlink:type="arc" />
    <link:loc xlink:href="agnc-20200331.xsd#agnc_WeightedAverageLifeOtherDebt" xlink:label="loc_agnc_WeightedAverageLifeOtherDebt_311C1D3691BB52B196F25C8840F3BF00" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_6D02E721DA1B5F4094D04610D101E552" xlink:to="loc_agnc_WeightedAverageLifeOtherDebt_311C1D3691BB52B196F25C8840F3BF00" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C1C8BE2203BDAAD1E948E54D30C6B9C4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_2437FC892112218A98F4E54D30C6F86A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C1C8BE2203BDAAD1E948E54D30C6B9C4" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_2437FC892112218A98F4E54D30C6F86A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_0DDAE8408E29258CCD49E54D30C67B9A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C1C8BE2203BDAAD1E948E54D30C6B9C4" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_0DDAE8408E29258CCD49E54D30C67B9A" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>
