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    <link:label id="lab_agnc_ThirtyOneToNinetyMember_80C0DE097A3ADE988213A7898C075E6F_documentation_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_80C0DE097A3ADE988213A7898C075E6F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">thirty one to ninety [Member]</link:label>
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    <link:label id="lab_agnc_InterestIncomePolicyTextBlock_5EF548F65EBB505D08ABA7898B4D5C26_label_en-US" xlink:label="lab_agnc_InterestIncomePolicyTextBlock_5EF548F65EBB505D08ABA7898B4D5C26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Income [Policy Text Block]</link:label>
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    <link:label id="lab_agnc_ManagementAgreementTextBlock_0E9A218A758EC124911DA7898B4D624F_label_en-US" xlink:label="lab_agnc_ManagementAgreementTextBlock_0E9A218A758EC124911DA7898B4D624F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Management Agreement [Text Block]</link:label>
    <link:label id="lab_agnc_ManagementAgreementTextBlock_0E9A218A758EC124911DA7898B4D624F_documentation_en-US" xlink:label="lab_agnc_ManagementAgreementTextBlock_0E9A218A758EC124911DA7898B4D624F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">MTGE Management Agreement [Text Block]</link:label>
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    <link:label id="lab_us-gaap_AssetsAbstract_FCA2A1B348009E5E3FC6D5EDB695E450_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract_FCA2A1B348009E5E3FC6D5EDB695E450" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets:</link:label>
    <link:label id="lab_us-gaap_AssetsAbstract_FCA2A1B348009E5E3FC6D5EDB695E450_label_en-US" xlink:label="lab_us-gaap_AssetsAbstract_FCA2A1B348009E5E3FC6D5EDB695E450" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Assets [Abstract]</link:label>
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    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_64CECEC2A805D4332A8BD5EDB696DB33_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_64CECEC2A805D4332A8BD5EDB696DB33" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities, at fair value (including pledged securities of $67,889 and $53,055, respectively)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_64CECEC2A805D4332A8BD5EDB696DB33" xlink:type="locator" />
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    <link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_BF0277F378BA0B91DBF5D5EDB696BAC9_verboseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_BF0277F378BA0B91DBF5D5EDB696BAC9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Agency securities transferred to consolidated variable interest entities, at fair value (pledged securities)</link:label>
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    <link:label id="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_9680994B265D86E5D96FD5EDB6969719_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_9680994B265D86E5D96FD5EDB6969719" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Credit risk transfer securities, at fair value (including pledged securities of $44 and $0, respectively)</link:label>
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    <link:label id="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_49F9B9D194F22235075EA7898F1A2522_terseLabel_en-US" xlink:label="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_49F9B9D194F22235075EA7898F1A2522" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gross gain on sale of investment securities</link:label>
    <link:label id="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_49F9B9D194F22235075EA7898F1A2522_label_en-US" xlink:label="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_49F9B9D194F22235075EA7898F1A2522" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Marketable Securities, Realized Gain (Loss)</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesRealizedGainLoss" xlink:label="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_49F9B9D194F22235075EA7898F1A2522" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_49F9B9D194F22235075EA7898F1A2522" xlink:to="lab_us-gaap_MarketableSecuritiesRealizedGainLoss_49F9B9D194F22235075EA7898F1A2522" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EFCAB0D1E8A6A874B7DFA7898F1A8DCC_negatedLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EFCAB0D1E8A6A874B7DFA7898F1A8DCC" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Gross loss on sale of investment securities</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EFCAB0D1E8A6A874B7DFA7898F1A8DCC_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EFCAB0D1E8A6A874B7DFA7898F1A8DCC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Available-for-sale Securities, Gross Realized Losses</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EFCAB0D1E8A6A874B7DFA7898F1A8DCC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EFCAB0D1E8A6A874B7DFA7898F1A8DCC" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EFCAB0D1E8A6A874B7DFA7898F1A8DCC" xlink:type="arc" />
    <link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_00AA1F5B5428CB9122DDA7898CE5DED2_verboseLabel_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_00AA1F5B5428CB9122DDA7898CE5DED2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Summary of Significant Accounting Policies</link:label>
    <link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_00AA1F5B5428CB9122DDA7898CE5DED2_label_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_00AA1F5B5428CB9122DDA7898CE5DED2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Significant Accounting Policies [Text Block]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_00AA1F5B5428CB9122DDA7898CE5DED2" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SignificantAccountingPoliciesTextBlock_00AA1F5B5428CB9122DDA7898CE5DED2" xlink:to="lab_us-gaap_SignificantAccountingPoliciesTextBlock_00AA1F5B5428CB9122DDA7898CE5DED2" xlink:type="arc" />
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718_terseLabel_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common stock, Value of Shares Approved for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718_label_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common stock, Value of Shares Approved for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718_documentation_en-US" xlink:label="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The dollar value amount approved to issue common stock under an At-the-Market Offering program.</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_CommonstockValueofSharesApprovedforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718" xlink:to="lab_agnc_CommonstockValueofSharesApprovedforFutureIssuance_EF363A358F3F96336054D5E8695E7718" xlink:type="arc" />
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359_terseLabel_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359_label_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common stock, Value of Shares Remaining for Future Issuance</link:label>
    <link:label id="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359_documentation_en-US" xlink:label="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The remaining dollar value amount approved to issue common stock under an At-the-Market program</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_CommonstockValueofSharesRemainingforFutureIssuance" xlink:label="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359" xlink:to="lab_agnc_CommonstockValueofSharesRemainingforFutureIssuance_3F8C157300C5002924D0D5E8695F4359" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityOvernightMember_4DA9589BB0EF84699C42D567A5A81164_terseLabel_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_4DA9589BB0EF84699C42D567A5A81164" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:label id="lab_us-gaap_MaturityOvernightMember_4DA9589BB0EF84699C42D567A5A81164_label_en-US" xlink:label="lab_us-gaap_MaturityOvernightMember_4DA9589BB0EF84699C42D567A5A81164" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maturity Overnight [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MaturityOvernightMember" xlink:label="loc_us-gaap_MaturityOvernightMember_4DA9589BB0EF84699C42D567A5A81164" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityOvernightMember_4DA9589BB0EF84699C42D567A5A81164" xlink:to="lab_us-gaap_MaturityOvernightMember_4DA9589BB0EF84699C42D567A5A81164" xlink:type="arc" />
    <link:label id="lab_us-gaap_MaturityUpTo30DaysMember_33E1019B37F0674E7E2BD567A5A8A49F_verboseLabel_en-US" xlink:label="lab_us-gaap_MaturityUpTo30DaysMember_33E1019B37F0674E7E2BD567A5A8A49F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">30 Days or Less [Member]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MaturityUpTo30DaysMember" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_33E1019B37F0674E7E2BD567A5A8A49F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaturityUpTo30DaysMember_33E1019B37F0674E7E2BD567A5A8A49F" xlink:to="lab_us-gaap_MaturityUpTo30DaysMember_33E1019B37F0674E7E2BD567A5A8A49F" xlink:type="arc" />
    <link:label id="lab_agnc_ThirtyOneToNinetyMember_D20AD5379A790427C675D567A5A9513B_verboseLabel_en-US" xlink:label="lab_agnc_ThirtyOneToNinetyMember_D20AD5379A790427C675D567A5A9513B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">1 to 3 Months</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_ThirtyOneToNinetyMember" xlink:label="loc_agnc_ThirtyOneToNinetyMember_D20AD5379A790427C675D567A5A9513B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_ThirtyOneToNinetyMember_D20AD5379A790427C675D567A5A9513B" xlink:to="lab_agnc_ThirtyOneToNinetyMember_D20AD5379A790427C675D567A5A9513B" xlink:type="arc" />
    <link:label id="lab_agnc_A4to6MonthsMember_706B841FEFF6106B122BD567A5A9D59A_terseLabel_en-US" xlink:label="lab_agnc_A4to6MonthsMember_706B841FEFF6106B122BD567A5A9D59A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">3 to 6 Months</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_A4to6MonthsMember" xlink:label="loc_agnc_A4to6MonthsMember_706B841FEFF6106B122BD567A5A9D59A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A4to6MonthsMember_706B841FEFF6106B122BD567A5A9D59A" xlink:to="lab_agnc_A4to6MonthsMember_706B841FEFF6106B122BD567A5A9D59A" xlink:type="arc" />
    <link:label id="lab_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F_verboseLabel_en-US" xlink:label="lab_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">6 to 9 Months</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F_label_en-US" xlink:label="lab_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:label id="lab_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F_documentation_en-US" xlink:label="lab_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">7 to 9 months [Member]</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_A7to9monthsMember" xlink:label="loc_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F" xlink:to="lab_agnc_A7to9monthsMember_3C4F2E708E5C07A3C970D567A5A91A7F" xlink:type="arc" />
    <link:label id="lab_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548_verboseLabel_en-US" xlink:label="lab_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">9 to 12 Months</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548_label_en-US" xlink:label="lab_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:label id="lab_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548_documentation_en-US" xlink:label="lab_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">10 to 12 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_A10to12MonthsMember" xlink:label="loc_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548" xlink:to="lab_agnc_A10to12MonthsMember_5976EFF179AA632066A1D567A5A9D548" xlink:type="arc" />
    <link:label id="lab_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99_terseLabel_en-US" xlink:label="lab_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">12 to 24 Months</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99_label_en-US" xlink:label="lab_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:label id="lab_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99_documentation_en-US" xlink:label="lab_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">13 to 24 Months [Member]</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_A13to24MonthsMember" xlink:label="loc_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99" xlink:to="lab_agnc_A13to24MonthsMember_55723028FA2802A61709D567A5A93B99" xlink:type="arc" />
    <link:label id="lab_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C_terseLabel_en-US" xlink:label="lab_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">24 to 36 Months</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C_label_en-US" xlink:label="lab_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:label id="lab_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C_documentation_en-US" xlink:label="lab_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">25 to 36 months [Member]</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_A25to36monthsMember" xlink:label="loc_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C" xlink:to="lab_agnc_A25to36monthsMember_CC12779523206677A4E9D567A5AA940C" xlink:type="arc" />
    <link:label id="lab_agnc_A37to48monthsMember_22FCE2FCA222E177A5E2D567A5AA9169_verboseLabel_en-US" xlink:label="lab_agnc_A37to48monthsMember_22FCE2FCA222E177A5E2D567A5AA9169" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">36 to 48 months</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_A37to48monthsMember" xlink:label="loc_agnc_A37to48monthsMember_22FCE2FCA222E177A5E2D567A5AA9169" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_agnc_A37to48monthsMember_22FCE2FCA222E177A5E2D567A5AA9169" xlink:to="lab_agnc_A37to48monthsMember_22FCE2FCA222E177A5E2D567A5AA9169" xlink:type="arc" />
    <link:label id="lab_agnc_A49to60MonthsMember_2D882CF8E4B7987E2326D567A5AA357C_verboseLabel_en-US" xlink:label="lab_agnc_A49to60MonthsMember_2D882CF8E4B7987E2326D567A5AA357C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">48 to 60 Months</link:label>
    <link:loc xlink:href="agnc-20180930.xsd#agnc_A49to60MonthsMember" xlink:label="loc_agnc_A49to60MonthsMember_2D882CF8E4B7987E2326D567A5AA357C" xlink:type="locator" />
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